HRP20090187T1 - Bengamide derivatives and use thereof for the treatment of cancer - Google Patents
Bengamide derivatives and use thereof for the treatment of cancerInfo
- Publication number
- HRP20090187T1 HRP20090187T1 HR20090187T HRP20090187T HRP20090187T1 HR P20090187 T1 HRP20090187 T1 HR P20090187T1 HR 20090187 T HR20090187 T HR 20090187T HR P20090187 T HRP20090187 T HR P20090187T HR P20090187 T1 HRP20090187 T1 HR P20090187T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- treatment
- bengamide derivatives
- bengamide
- derivatives
- Prior art date
Links
- GPVKLYONJSSZFL-UHFFFAOYSA-N NSC 750259 Natural products CCC(C)C=CC(O)C(O)C(O)C(OC)C(=O)NC1CCCCNC1=O GPVKLYONJSSZFL-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229930195545 bengamide Natural products 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Abstract
Spoj formule (I), gdje R1 jest H ili (C1-C6)-alkilR2 jest H ili OH, iR3 jest H ili -C(=O)-(C1-C6)-alkil, ili njegova fiziološki podnošljiva sol. Patent sadrži još 9 patentnih zahtjeva.A compound of formula (I), wherein R 1 is H or (C 1 -C 6) -alkylR 2 is H or OH, and R 3 is H or -C (= O) - (C 1 -C 6) -alkyl, or a physiologically tolerable salt thereof. The patent contains 9 more patent claims.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10349669A DE10349669B3 (en) | 2003-10-24 | 2003-10-24 | Bengamide derivatives, process for their preparation and their use |
PCT/EP2004/011244 WO2005044803A1 (en) | 2003-10-24 | 2004-10-08 | Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090187T1 true HRP20090187T1 (en) | 2009-05-31 |
Family
ID=34484998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090187T HRP20090187T1 (en) | 2003-10-24 | 2009-03-31 | Bengamide derivatives and use thereof for the treatment of cancer |
Country Status (30)
Country | Link |
---|---|
EP (2) | EP1873146B1 (en) |
JP (1) | JP4769190B2 (en) |
KR (1) | KR20060120044A (en) |
CN (2) | CN100398520C (en) |
AR (1) | AR046553A1 (en) |
AT (2) | ATE420074T1 (en) |
AU (1) | AU2004287561B2 (en) |
BR (1) | BRPI0415529A (en) |
CA (1) | CA2543003A1 (en) |
CL (1) | CL2009000674A1 (en) |
CY (1) | CY1110458T1 (en) |
DE (3) | DE10349669B3 (en) |
DK (1) | DK1680405T3 (en) |
ES (1) | ES2320894T3 (en) |
HK (1) | HK1098131A1 (en) |
HR (1) | HRP20090187T1 (en) |
IL (1) | IL174524A (en) |
MA (1) | MA28213A1 (en) |
ME (1) | MEP33108A (en) |
MX (1) | MXPA06004084A (en) |
NO (1) | NO20062149L (en) |
NZ (1) | NZ546744A (en) |
PL (1) | PL1680405T3 (en) |
PT (1) | PT1680405E (en) |
RS (1) | RS20060263A (en) |
RU (1) | RU2357956C2 (en) |
SI (1) | SI1680405T1 (en) |
UY (1) | UY28574A1 (en) |
WO (1) | WO2005044803A1 (en) |
ZA (1) | ZA200602231B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2878528B1 (en) | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDES, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
FR2878525B1 (en) * | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | BENGAMIDES HAVING SUBSTITUTED CAPROLACTAM CYCLE, PREPARATION METHOD, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
FR2901556A1 (en) | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE DERIVATIVES, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
FR2901555A1 (en) | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZOTHIAZEPINE, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
FR2901554B1 (en) | 2006-05-24 | 2011-04-01 | Sanofi Aventis | 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZAZEPINE, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5140099A1 (en) * | 1998-11-17 | 2002-03-22 | Novartis Ag | CERTAIN SUBSTITUTED CAPROLACTAMAS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND ITS USE IN TUMORS TREATMENT |
AU2001295206A1 (en) * | 2000-05-11 | 2001-11-20 | Novartis Ag | Substituted caprolactam carbonates and ethers and their use as anti-tumor agents |
JP2004262793A (en) * | 2003-02-28 | 2004-09-24 | Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai | Compound n-9011, its production method and use |
CA2533335A1 (en) * | 2003-07-25 | 2005-02-17 | Novartis Ag | Substituted lactams and their use as anti-cancer agents |
-
2003
- 2003-10-24 DE DE10349669A patent/DE10349669B3/en not_active Expired - Fee Related
-
2004
- 2004-10-08 PL PL04765884T patent/PL1680405T3/en unknown
- 2004-10-08 KR KR1020067007889A patent/KR20060120044A/en not_active Application Discontinuation
- 2004-10-08 ME MEP-331/08A patent/MEP33108A/en unknown
- 2004-10-08 EP EP07007021A patent/EP1873146B1/en active Active
- 2004-10-08 WO PCT/EP2004/011244 patent/WO2005044803A1/en active Application Filing
- 2004-10-08 PT PT04765884T patent/PT1680405E/en unknown
- 2004-10-08 CN CNB2004800306469A patent/CN100398520C/en not_active Expired - Fee Related
- 2004-10-08 DE DE502004008837T patent/DE502004008837D1/en active Active
- 2004-10-08 ES ES04765884T patent/ES2320894T3/en active Active
- 2004-10-08 NZ NZ546744A patent/NZ546744A/en unknown
- 2004-10-08 BR BRPI0415529-7A patent/BRPI0415529A/en not_active IP Right Cessation
- 2004-10-08 EP EP04765884A patent/EP1680405B1/en active Active
- 2004-10-08 RS YUP-2006/0263A patent/RS20060263A/en unknown
- 2004-10-08 CN CNA2008100958532A patent/CN101294173A/en active Pending
- 2004-10-08 MX MXPA06004084A patent/MXPA06004084A/en active IP Right Grant
- 2004-10-08 RU RU2006117769/04A patent/RU2357956C2/en not_active IP Right Cessation
- 2004-10-08 AT AT04765884T patent/ATE420074T1/en active
- 2004-10-08 DE DE502004011536T patent/DE502004011536D1/en active Active
- 2004-10-08 SI SI200431054T patent/SI1680405T1/en unknown
- 2004-10-08 AU AU2004287561A patent/AU2004287561B2/en not_active Expired - Fee Related
- 2004-10-08 AT AT07007021T patent/ATE477244T1/en not_active IP Right Cessation
- 2004-10-08 DK DK04765884T patent/DK1680405T3/en active
- 2004-10-08 CA CA002543003A patent/CA2543003A1/en not_active Abandoned
- 2004-10-08 JP JP2006535987A patent/JP4769190B2/en not_active Expired - Fee Related
- 2004-10-21 AR ARP040103818A patent/AR046553A1/en not_active Application Discontinuation
- 2004-10-22 UY UY28574A patent/UY28574A1/en unknown
-
2006
- 2006-03-16 ZA ZA200602231A patent/ZA200602231B/en unknown
- 2006-03-23 IL IL174524A patent/IL174524A/en not_active IP Right Cessation
- 2006-04-21 MA MA28955A patent/MA28213A1/en unknown
- 2006-05-12 NO NO20062149A patent/NO20062149L/en not_active Application Discontinuation
-
2007
- 2007-02-15 HK HK07101845A patent/HK1098131A1/en not_active IP Right Cessation
-
2009
- 2009-03-19 CL CL2009000674A patent/CL2009000674A1/en unknown
- 2009-03-23 CY CY20091100336T patent/CY1110458T1/en unknown
- 2009-03-31 HR HR20090187T patent/HRP20090187T1/en unknown
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