SG11202003907WA - Acoustic transducer drive and controller - Google Patents

Acoustic transducer drive and controller

Info

Publication number
SG11202003907WA
SG11202003907WA SG11202003907WA SG11202003907WA SG11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA
Authority
SG
Singapore
Prior art keywords
controller
acoustic transducer
transducer drive
drive
acoustic
Prior art date
Application number
SG11202003907WA
Other languages
English (en)
Inventor
Bart Lipkens
Ronald Musiak
John Artis
Original Assignee
Flodesign Sonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flodesign Sonics Inc filed Critical Flodesign Sonics Inc
Publication of SG11202003907WA publication Critical patent/SG11202003907WA/en

Links

Classifications

    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R3/00Circuits for transducers, loudspeakers or microphones
    • H04R3/04Circuits for transducers, loudspeakers or microphones for correcting frequency response
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283Settling tanks provided with vibrators
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D17/00Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02Separation of non-miscible liquids
    • B01D17/04Breaking emulsions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30Control equipment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/0207Driving circuits
    • B06B1/0223Driving circuits for generating signals continuous in time
    • B06B1/0238Driving circuits for generating signals continuous in time of a single frequency, e.g. a sine-wave
    • B06B1/0246Driving circuits for generating signals continuous in time of a single frequency, e.g. a sine-wave with a feedback signal
    • B06B1/0261Driving circuits for generating signals continuous in time of a single frequency, e.g. a sine-wave with a feedback signal taken from a transducer or electrode connected to the driving transducer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/06Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
    • B06B1/0644Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00Details of transducers, loudspeakers or microphones
    • H04R1/20Arrangements for obtaining desired frequency or directional characteristics
    • H04R1/22Arrangements for obtaining desired frequency or directional characteristics for obtaining desired frequency characteristic only 
    • H04R1/24Structural combinations of separate transducers or of two parts of the same transducer and responsive respectively to two or more frequency ranges
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00Details of transducers, loudspeakers or microphones
    • H04R1/20Arrangements for obtaining desired frequency or directional characteristics
    • H04R1/22Arrangements for obtaining desired frequency or directional characteristics for obtaining desired frequency characteristic only 
    • H04R1/28Transducer mountings or enclosures modified by provision of mechanical or acoustic impedances, e.g. resonator, damping means
    • H04R1/2807Enclosures comprising vibrating or resonating arrangements
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R17/00Piezoelectric transducers; Electrostrictive transducers
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R9/00Transducers of moving-coil, moving-strip, or moving-wire type
    • H04R9/06Loudspeakers
    • H04R9/063Loudspeakers using a plurality of acoustic drivers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B2201/00Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
    • B06B2201/70Specific application
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R2201/00Details of transducers, loudspeakers or microphones covered by H04R1/00 but not provided for in any of its subgroups
    • H04R2201/003Mems transducers or their use

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acoustics & Sound (AREA)
  • Signal Processing (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • Otolaryngology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Transducers For Ultrasonic Waves (AREA)
  • Circuit For Audible Band Transducer (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Burglar Alarm Systems (AREA)
  • Vehicle Body Suspensions (AREA)
SG11202003907WA 2017-12-14 2018-12-14 Acoustic transducer drive and controller SG11202003907WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762599017P 2017-12-14 2017-12-14
US201862614354P 2018-01-05 2018-01-05
PCT/US2018/065839 WO2019118921A1 (en) 2017-12-14 2018-12-14 Acoustic transducer drive and controller

Publications (1)

Publication Number Publication Date
SG11202003907WA true SG11202003907WA (en) 2020-05-28

Family

ID=66816603

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003907WA SG11202003907WA (en) 2017-12-14 2018-12-14 Acoustic transducer drive and controller

Country Status (11)

Country Link
US (2) US10785574B2 (pt)
EP (1) EP3725092A4 (pt)
JP (1) JP2021507561A (pt)
KR (2) KR20220066413A (pt)
CN (2) CN111480345B (pt)
AU (1) AU2018385759B2 (pt)
BR (1) BR112020009889A2 (pt)
CA (1) CA3085784A1 (pt)
IL (1) IL274333A (pt)
SG (1) SG11202003907WA (pt)
WO (1) WO2019118921A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
EP3501619B1 (en) * 2017-12-20 2023-10-18 Nokia Technologies Oy Apparatus for collecting particles within a fluid
CA3181267A1 (en) * 2020-06-17 2021-12-23 Dipen N. Sinha Destruction of airborne pathogens, and microorganisms on grains and dried food using ultrasound
JP7484534B2 (ja) 2020-07-30 2024-05-16 セイコーエプソン株式会社 流体デバイス
CN114515184B (zh) * 2020-11-20 2024-03-15 深圳开立生物医疗科技股份有限公司 一种超声刀系统及其功率驱动方法、装置和主机
CN114117957A (zh) * 2021-11-18 2022-03-01 浙江大学 一种流体动力式低频换能器及其设计方法

Family Cites Families (837)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1017524A (en) 1911-05-01 1912-02-13 Robert George Ferguson Flush-tank.
US1016731A (en) 1911-10-11 1912-02-06 Stephen Bennis Tender-scoop.
US2473971A (en) 1944-02-25 1949-06-21 Donald E Ross Underwater transducer
US2667944A (en) 1949-12-10 1954-02-02 Combustion Eng Cyclone separator
US3372370A (en) 1965-09-22 1968-03-05 Aquasonics Engineering Company Electroacoustic transducer
US3555311A (en) 1969-01-23 1971-01-12 Marquardt Corp High pressure piezoelectric transducer
US3948489A (en) 1972-10-30 1976-04-06 Sawyer Harold T In-line mixer for fluids
US4158629A (en) 1974-08-12 1979-06-19 Vernon D. Beehler Dynamic self-cleaning filter for liquids
US4204096A (en) 1974-12-02 1980-05-20 Barcus Lester M Sonic transducer mounting
US4048454A (en) 1974-12-02 1977-09-13 Barcus Lester M Sonic transducer employing rigid radiating member
US4055491A (en) 1976-06-02 1977-10-25 Porath Furedi Asher Apparatus and method for removing fine particles from a liquid medium by ultrasonic waves
SU629496A1 (ru) 1976-08-01 1978-10-25 Институт Радиофизики И Электроники Ан Украинской Сср Акустический преобразователь ультразвука
US4065875A (en) 1976-09-17 1978-01-03 University Of Delaware Selective destruction of certain algae
JPS6034433B2 (ja) 1977-03-07 1985-08-08 株式会社豊田中央研究所 超音波変換器
US4118649A (en) 1977-05-25 1978-10-03 Rca Corporation Transducer assembly for megasonic cleaning
US4125789A (en) 1977-06-07 1978-11-14 Sundstrand Corporation Biasing and scaling circuit for transducers
US4165273A (en) 1977-12-20 1979-08-21 Azarov Nikolai N Device for producing deeply desalted water
US4320659A (en) 1978-02-27 1982-03-23 Panametrics, Inc. Ultrasonic system for measuring fluid impedance or liquid level
AU529113B2 (en) 1978-04-19 1983-05-26 Commonwealth Of Australia, The Ultrasonic transducer array
US4211949A (en) 1978-11-08 1980-07-08 General Electric Company Wear plate for piezoelectric ultrasonic transducer arrays
CA1141629A (en) 1979-07-31 1983-02-22 Roger F. Potts Machine for cleaning plastic containers
US4264003A (en) 1979-09-12 1981-04-28 Fruehauf Corporation Foldable unloading machine having full circle swivelling action
FR2485858B1 (fr) 1980-06-25 1986-04-11 Commissariat Energie Atomique Procede de fabrication de transducteurs ultrasonores de formes complexes et application a l'obtention de transducteurs annulaires
DE3027433A1 (de) 1980-07-19 1982-02-18 Messerschmitt-Bölkow-Blohm GmbH, 8000 München Verfahren zur trennung von gemischen
US5834871A (en) 1996-08-05 1998-11-10 Puskas; William L. Apparatus and methods for cleaning and/or processing delicate parts
DE3218488A1 (de) 1982-05-15 1983-11-17 Battelle-Institut E.V., 6000 Frankfurt Verfahren und vorrichtung zum sortieren von partikeln nach unterschiedlichen dichtebereichen
US4552669A (en) 1983-04-18 1985-11-12 Mott Metallurgical Corporation Pneumatic hydro-pulse filter system and method of operation
US4484907A (en) 1983-10-20 1984-11-27 E. I. Du Pont De Nemours And Company Microtube adapter having a holding and uncapping apparatus
US4743361A (en) 1983-10-31 1988-05-10 Internationale Octrooi Maatschappij "Octropa" Bv Manipulation of particles
GB8417240D0 (en) 1984-07-06 1984-08-08 Unilever Plc Particle separation
EP0278108B1 (de) 1984-07-18 1989-08-16 Schenck Auto-Service-Geräte GmbH Verfahren und Vorrichtung zum Stillsetzen eines rotierenden Körpers
CN85100483B (zh) 1985-04-01 1988-10-19 上海灯泡厂 超声波换能器用背载材料
US4666595A (en) 1985-09-16 1987-05-19 Coulter Electronics, Inc. Apparatus for acoustically removing particles from a magnetic separation matrix
US4759775A (en) 1986-02-21 1988-07-26 Utah Bioresearch, Inc. Methods and apparatus for moving and separating materials exhibiting different physical properties
US4983189A (en) 1986-02-21 1991-01-08 Technical Research Associates, Inc. Methods and apparatus for moving and separating materials exhibiting different physical properties
US4699588A (en) 1986-03-06 1987-10-13 Sonotech, Inc. Method and apparatus for conducting a process in a pulsating environment
GB8612759D0 (en) 1986-05-27 1986-07-02 Unilever Plc Manipulating particulate matter
US4823042A (en) * 1986-07-18 1989-04-18 Rich-Mar Corporation Sonic transducer and method for making the same
BE905707A (nl) 1986-11-06 1987-03-02 Poppe Willy Dekbed.
AT389235B (de) 1987-05-19 1989-11-10 Stuckart Wolfgang Verfahren zur reinigung von fluessigkeiten mittels ultraschall und vorrichtungen zur durchfuehrung dieses verfahrens
US4821838A (en) 1987-10-30 1989-04-18 Hewlett-Packard Company Acoustic damper
JPH01134216A (ja) 1987-11-19 1989-05-26 Agency Of Ind Science & Technol 3次元定在波音場の可視化方法
US4860993A (en) 1988-01-14 1989-08-29 Teledyne Industries, Inc. Valve design to reduce cavitation and noise
US4836684A (en) 1988-02-18 1989-06-06 Ultrasonic Power Corporation Ultrasonic cleaning apparatus with phase diversifier
WO1989011899A1 (en) 1988-06-08 1989-12-14 Invitron Corporation Tandem hollow fiber cell culture product harvest system
AT390739B (de) * 1988-11-03 1990-06-25 Ewald Dipl Ing Dr Benes Verfahren und einrichtung zur separation von teilchen, welche in einem dispersionsmittel dispergiert sind
FR2638659B1 (fr) 1988-11-07 1992-06-12 Framatome Sa Appareil de filtration comportant un dispositif de decolmatage par ultrasons et procede de decolmatage correspondant
JPH02290266A (ja) 1989-04-28 1990-11-30 Mitsubishi Heavy Ind Ltd 超音波式原油脱水・脱塩装置
GB9005705D0 (en) 1990-03-14 1990-05-09 Health Lab Service Board Particle manipulation
US5085783A (en) 1990-08-16 1992-02-04 Case Western Reserve University Acoustically driven particle separation method and apparatus
US5059811A (en) 1990-08-30 1991-10-22 Great Lakes Instruments, Inc. Turbidimeter having a baffle assembly for removing entrained gas
RU2085933C1 (ru) 1991-08-14 1997-07-27 Кирпиченко Борис Иванович Устройство для ультразвукового контроля плотности раствора
RU2037327C1 (ru) 1991-12-09 1995-06-19 Александр Александрович Ковалев Ультразвуковой фильтр
GB2265004B (en) 1992-03-10 1996-01-10 Univ Cardiff Immuno-agglutination assay using ultrasonic standing wave field
CA2133823C (en) 1992-04-06 2002-10-15 Norman D.G. Mountford Ultrasonic treatment of liquids in particular metal melts
US6216538B1 (en) 1992-12-02 2001-04-17 Hitachi, Ltd. Particle handling apparatus for handling particles in fluid by acoustic radiation pressure
AT398707B (de) 1993-05-11 1995-01-25 Trampler Felix Mehrschichtiger piezoelektrischer resonator für die separation von suspendierten teilchen
CA2137699A1 (en) 1993-05-11 1994-11-24 Felix Trampler Multi-layered piezoelectric resonator for the separation of suspended particles
US5626767A (en) 1993-07-02 1997-05-06 Sonosep Biotech Inc. Acoustic filter for separating and recycling suspended particles
US5443985A (en) 1993-07-22 1995-08-22 Alberta Research Council Cell culture bioreactor
AU688334B2 (en) 1993-09-07 1998-03-12 Siemens Medical Solutions Usa, Inc. Broadband phased array transducer design with frequency controlled two dimension capability and methods for manufacture thereof
US5415175A (en) 1993-09-07 1995-05-16 Acuson Corporation Broadband phased array transducer design with frequency controlled two dimension capability and methods for manufacture thereof
US5431817A (en) 1993-09-13 1995-07-11 W. R. Grace & Co.-Conn. Bleach resistant polysulfone/polyurethane composite membranes
US5371429A (en) 1993-09-28 1994-12-06 Misonix, Inc. Electromechanical transducer device
US5395592A (en) 1993-10-04 1995-03-07 Bolleman; Brent Acoustic liquid processing device
US5452267A (en) 1994-01-27 1995-09-19 Magnetrol International, Inc. Midrange ultrasonic transducer
US5562823A (en) 1994-04-25 1996-10-08 Reeves; William Combination centrifugal and sonic device for separating components within a solution
EP0764265A4 (en) 1994-06-07 1998-05-20 Univ Boston ACOUSTIC DETECTION OF PARTICLES
US5560362A (en) 1994-06-13 1996-10-01 Acuson Corporation Active thermal control of ultrasound transducers
US5475486A (en) 1994-10-21 1995-12-12 Hach Company Flow cell system for turbidimeter
JP3487699B2 (ja) 1995-11-08 2004-01-19 株式会社日立製作所 超音波処理方法および装置
JP3875736B2 (ja) 1995-11-14 2007-01-31 株式会社協和エクシオ 排水処理方法および装置
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
US5688405A (en) 1996-02-28 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for separating particulate matter from a fluid
AU2318597A (en) 1996-03-19 1997-10-10 Ozone Sterilization Products, Inc. Ozone sterilizer and generator
NL1003595C2 (nl) 1996-04-10 1997-10-14 Tno Werkwijze en inrichting voor het karakteriseren van suspensies.
MX9604952A (es) 1996-10-18 1998-04-30 Servicios Condumex Sa Clasificador y reactor hidraulico de particulas solidas con aplicacion de ultrasonido.
GB9621832D0 (en) 1996-10-19 1996-12-11 Univ Cardiff Removing partiles from suspension
DE19648519C2 (de) 1996-11-23 2000-11-16 Preussag Wassertechnik Gmbh Verfahren und Anlage zur Stofftrennung mittels Membranfiltration
GB9708984D0 (en) 1997-05-03 1997-06-25 Univ Cardiff Particle manipulation
US5951456A (en) 1997-05-16 1999-09-14 Scott; Harold W. Ultrasonic methods and apparatus for separating materials in a fluid mixture
DE69810999T2 (de) 1997-06-17 2003-08-28 Konishiroku Photo Ind Verfahren und Vorrichtung zum Entfernen von Blasen aus einer Flüssigkeit unter Verwendung von Ultraschall
JPH1190110A (ja) 1997-09-16 1999-04-06 Konica Corp 超音波脱泡方法、感光材料の生産方法及び超音波脱泡装置
US6029518A (en) 1997-09-17 2000-02-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Manipulation of liquids using phased array generation of acoustic radiation pressure
US6280388B1 (en) 1997-11-19 2001-08-28 Boston Scientific Technology, Inc. Aerogel backed ultrasound transducer
US6326213B1 (en) 1998-02-09 2001-12-04 The Boards Of Govenors For Higher Education, State Of Rhode Island And Providence Plantations Acoustic standing-wave enhancement of a fiber-optic Salmonella biosensor
DE19815882A1 (de) 1998-04-08 1999-10-14 Fuhr Guenther Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen
DE19820466C2 (de) 1998-05-07 2002-06-13 Fraunhofer Ges Forschung Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen
JP2000024431A (ja) 1998-07-14 2000-01-25 Hitachi Ltd 微粒子処理装置
US6090295A (en) 1998-08-11 2000-07-18 University Technology Corporation Method and apparatus for acoustically demixing aqueous solutions
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
CN1286668A (zh) 1998-11-20 2001-03-07 普拉乌道株式会社 液体处理方法、液体处理装置及液体处理系统
US6166231A (en) 1998-12-15 2000-12-26 Martek Biosciences Corporation Two phase extraction of oil from biomass
WO2000041794A1 (en) 1999-01-15 2000-07-20 University College Cardiff Consultants Ltd. Particle manipulation
CN1181337C (zh) 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6314974B1 (en) 1999-06-28 2001-11-13 Fairchild Semiconductor Corporation Potted transducer array with matching network in a multiple pass configuration
GB9916851D0 (en) 1999-07-20 1999-09-22 Univ Wales Bangor Manipulation of particles in liquid media
JP4020559B2 (ja) * 2000-02-04 2007-12-12 オリンパス株式会社 超音波振動子駆動装置
AUPQ629100A0 (en) 2000-03-16 2000-04-15 Btf Pty Ltd Process for preparing controlled samples of particles such as microorganisms and cells
AU2001263213B2 (en) 2000-05-16 2005-05-19 Atrionix, Inc. Apparatus and method incorporating an ultrasound transducer onto a delivery member
US6395186B1 (en) 2000-06-20 2002-05-28 Delaware Capital Formation, Inc. Pressure liquid filtration with ultrasonic bridging prevention
US7319763B2 (en) * 2001-07-11 2008-01-15 American Technology Corporation Power amplification for parametric loudspeakers
EP1175931A1 (en) 2000-07-25 2002-01-30 Computer Cell Culture Center S.A. Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
AU2001288447A1 (en) 2000-08-28 2002-03-13 Ocean Power Corporation Method for pretreating water for desalination
CN100495030C (zh) 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
JP2004516468A (ja) 2000-12-18 2004-06-03 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 懸濁中の粒子の超音波サイズ測定方法および装置
SE0100820D0 (sv) 2001-03-09 2001-03-09 Erysave Ab Ideon Particle separation using an acoustic filter
SE522801C2 (sv) 2001-03-09 2004-03-09 Erysave Ab Anordning för att separera suspenderade partiklar från en fluid med ultraljud samt metod för sådan separering
SE0103013D0 (sv) 2001-03-09 2001-09-12 Erysave Ab Ideon System and method for treatment of whole blood
US6467350B1 (en) 2001-03-15 2002-10-22 The Regents Of The University Of California Cylindrical acoustic levitator/concentrator
US6770248B2 (en) 2001-05-04 2004-08-03 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Flowthrough device for the ultrasonic destruction of microorganisms in fluids
US6763722B2 (en) 2001-07-13 2004-07-20 Transurgical, Inc. Ultrasonic transducers
US6551248B2 (en) 2001-07-31 2003-04-22 Koninklijke Philips Electronics N.V. System for attaching an acoustic element to an integrated circuit
US7431892B2 (en) 2001-09-25 2008-10-07 Piezo Top Ltd. Apparatus for sterilizing a liquid with focused acoustic standing waves
DE10148916A1 (de) 2001-10-04 2003-04-17 Beatrix Christa Meier Ultraschallvorrichtung
US6487095B1 (en) 2001-10-31 2002-11-26 International Business Machines Corporation Multiphase zero-volt-switching resonant DC-DC regulator
US7470545B2 (en) 2001-11-05 2008-12-30 Rohm And Haas Company Buccal dissolution of active substances
AU2002343107A1 (en) 2001-11-27 2003-06-10 Euroflow (Uk) Limited Detection systems and methods
US6649069B2 (en) 2002-01-23 2003-11-18 Bae Systems Information And Electronic Systems Integration Inc Active acoustic piping
JP3633926B2 (ja) 2002-01-28 2005-03-30 松下電器産業株式会社 超音波送受信器および超音波流量計
EP1354941A1 (en) 2002-04-19 2003-10-22 Computer Cell Culture Center S.A. Apparatus and method for a cell culture in a bioreactor at high cell concentration
US6749666B2 (en) 2002-04-26 2004-06-15 Board Of Regents, The University Of Texas System Modulated acoustic aggiomeration system and method
KR100571803B1 (ko) 2002-05-03 2006-04-17 삼성전자주식회사 수소로 기능화된 반도체 탄소나노튜브를 포함하는 전자 소자 및 그 제조방법
AU2003240739A1 (en) 2002-06-03 2003-12-19 Shell Internationale Research Maatschappij B.V. Downhole desalination of aquifer water
US7846382B2 (en) 2002-06-04 2010-12-07 Protasis Corporation Method and device for ultrasonically manipulating particles within a fluid
US20040016699A1 (en) 2002-07-29 2004-01-29 Michael Bayevsky Systems and methods for ultrasonic cleaning of cross-flow membrane filters
US6938488B2 (en) 2002-08-21 2005-09-06 Battelle Memorial Institute Acoustic inspection device
GB0221391D0 (en) 2002-09-16 2002-10-23 Secr Defence Apparatus for directing particles in a fluid
US6881389B2 (en) 2002-09-24 2005-04-19 Edg, Inc. Removal of H2S and CO2 from a hydrocarbon fluid stream
GB0222421D0 (en) 2002-09-27 2002-11-06 Ratcliff Henry K Advanced ultrasonic processor
US7108137B2 (en) 2002-10-02 2006-09-19 Wisconsin Alumni Research Foundation Method and apparatus for separating particles by size
EP1565245A4 (en) 2002-11-01 2006-06-07 Univ Texas ACOUSTIC STIMULATION OF A STEAM DIFFUSION SYSTEM AND METHOD THEREOF
US6878288B2 (en) 2002-12-17 2005-04-12 Harold W. Scott System and apparatus for removing dissolved and suspended solids from a fluid stream
US7191787B1 (en) 2003-02-03 2007-03-20 Lam Research Corporation Method and apparatus for semiconductor wafer cleaning using high-frequency acoustic energy with supercritical fluid
SE0300290D0 (sv) 2003-02-05 2003-02-05 Siemens Elema Ab Acoustic meter assembly
AU2003270259A1 (en) 2003-03-06 2004-09-28 Eth Zurich Method for positioning small particles in a fluid
US7008540B1 (en) 2003-04-07 2006-03-07 The Ohio State University Ultrasonically cleaned membrane filtration system
DE10319467B3 (de) 2003-04-29 2004-07-22 Miele & Cie. Kg Einrichtung mit einem Trübungssensor für eine Geschirrspülmaschine oder Waschmaschine
US6990852B2 (en) 2003-07-28 2006-01-31 Becton Dickinson & Company System and method for detecting particles
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
CN1245231C (zh) 2003-08-27 2006-03-15 中国石油化工股份有限公司 顺流和逆流超声波联合作用使油水乳化物破乳的方法及装置
US7541166B2 (en) 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US7232016B2 (en) 2003-12-08 2007-06-19 General Motors Corporation Fluid damper having continuously variable damping response
JP4259525B2 (ja) * 2003-12-17 2009-04-30 パナソニック株式会社 成分分離デバイスおよびその製造方法並びにこれを用いた成分の分離方法
US7445716B2 (en) 2004-01-05 2008-11-04 Eaton Lp Crossflow pressure liquid filtration with ultrasonic enhancement
US8012355B2 (en) 2004-01-30 2011-09-06 Pss Acquisitionco Llc Molecular separator
JP2005249267A (ja) 2004-03-03 2005-09-15 Sanyo Electric Co Ltd 電子レンジ
US7044737B2 (en) 2004-03-05 2006-05-16 Liang Fu Ultrasound oral hygiene and therapeutic device
BRPI0510291A (pt) 2004-04-27 2007-10-30 Baxter Int sistema de reator com tanque agitado
EP1766608B1 (en) 2004-06-07 2017-08-09 Koninklijke Philips N.V. Acoustic device with variable focal length
JP2005349267A (ja) 2004-06-09 2005-12-22 Enomoto Bea Co Ltd 懸濁液分離装置及び懸濁液分離方法
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US20080272034A1 (en) 2004-08-16 2008-11-06 Searete Llc, Separation of particles from a fluid by wave action
AT413655B (de) 2004-08-19 2006-04-15 Felix Dipl Ing Dr Trampler Vorrichtung zur abscheidung von dispergierten partikeln
US7230882B2 (en) 2004-09-03 2007-06-12 Lowrance Electronics, Inc. Transducer support and associated lock
SE528313C2 (sv) 2004-09-24 2006-10-17 Spectronic Ab Metod och apparat för separering av partiklar med hjälp av ultraljudvågor
GB2420510B (en) 2004-11-25 2010-10-06 Cyclotech Ltd Methods and apparatus for conditioning and degassing liquids and gases in suspension
WO2006069181A2 (en) 2004-12-21 2006-06-29 Musc Foundation For Research Development Compositions and methods for promoting wound healing and tissue regeneration
CA2593374A1 (en) 2004-12-29 2006-07-06 Biogen Idec Ma Inc. Bioreactor process control system and method
FR2882939B1 (fr) 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
ES2716874T3 (es) 2005-03-23 2019-06-17 Genmab As Anticuerpos contra cd38 para el tratamiento del mieloma múltiple
US7704743B2 (en) 2005-03-30 2010-04-27 Georgia Tech Research Corporation Electrosonic cell manipulation device and method of use thereof
JP4770251B2 (ja) 2005-04-25 2011-09-14 パナソニック株式会社 成分分離デバイスおよびこれを用いた成分の分離方法
EP1915211B1 (en) 2005-07-07 2009-09-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for acoustic manipulation of particles, cells and viruses
WO2007016605A2 (en) 2005-08-01 2007-02-08 Covaris, Inc. An apparatus and a method for processing a sample using acoustic energy
JP4572789B2 (ja) * 2005-09-27 2010-11-04 パナソニック電工株式会社 超音波発生装置及び超音波美容装置
DE102005050167B4 (de) 2005-10-19 2009-02-19 Advalytix Ag Konzentrationsverfahren, Konzentrationsvorrichtung und Reaktionsverfahren
US7766121B2 (en) 2005-12-20 2010-08-03 Cyclotech Limited Methods and apparatus for conditioning and degassing liquids and gases in suspension
WO2007083295A2 (en) 2006-01-19 2007-07-26 Yeda Research And Development Co. Ltd. Device and method for particle manipulation in fluid
BRPI0708470A2 (pt) 2006-03-14 2011-05-31 Merck & Co Inc processo para a produção de partìculas cristalinas de um composto ativo orgánico, e, composição farmacêutica
US20070224676A1 (en) 2006-03-21 2007-09-27 Becton, Dickinson And Company Expandable culture roller bottle
CN1843945A (zh) 2006-05-16 2006-10-11 徐小宁 利用射流技术的海水淡化处理系统
US20070267351A1 (en) 2006-05-22 2007-11-22 Traceguard Technologies Inc. Low-frequency acoustic waves for collecting and/or moving particles inside articles
US20080011693A1 (en) 2006-07-12 2008-01-17 Ming Li Self-cleaning waste-water device and method
US8075786B2 (en) 2006-09-05 2011-12-13 The Board Of Regents Of The University Of Oklahoma Acoustic/pressure wave-driven separation device
US7763177B2 (en) 2006-10-26 2010-07-27 Atlantium Technologies Ltd. System and method for ultrasonic cleaning of ultraviolet disinfection system
JP4984849B2 (ja) 2006-11-27 2012-07-25 パナソニック株式会社 成分分離デバイスと、この成分分離デバイスを用いた化学分析デバイス
US7673516B2 (en) 2006-12-28 2010-03-09 Kimberly-Clark Worldwide, Inc. Ultrasonic liquid treatment system
US20080181828A1 (en) 2007-01-25 2008-07-31 Kluck William P Ultrasound one-quarter wave separator integrates with sterile tubing kit - optical sensing / valves manage purity - lowers apheresis extra corporeal blood volume - replacement for centrifuge
WO2008106403A2 (en) 2007-02-26 2008-09-04 Trustees Of Princeton University Turnable acoustic gradient index of refraction lens and system
CN101678250B (zh) 2007-03-02 2013-04-24 史密夫及内修公开有限公司 用于在生物样品过滤中通过超声、回洗和过滤器运动进行过滤器清洁的装置和方法
DE102008006501B4 (de) 2007-03-19 2013-05-16 Sonja Lauterborn Kombiniertes Ultraschall-Luft-Rückspülverfahren zur chemikalienfreien In- situ-Reinigung getauchter Membranen bei Rückspülung während des Betriebes
US8911460B2 (en) 2007-03-22 2014-12-16 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
EP2664916B1 (en) 2007-04-02 2017-02-08 Acoustic Cytometry Systems, Inc. Method for manipulating a fluid medium within a flow cell using acoustic focusing
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
EP2145687B1 (en) 2007-05-15 2014-12-03 Panasonic Corporation Component separation device
US7889601B2 (en) 2007-06-19 2011-02-15 Lockheed Martin Corporation Lightweight acoustic array
DE102007030904A1 (de) 2007-07-03 2009-02-05 Pharis Biotec Gmbh Humanes zirkulierendes antivirales Albumin-Fragment (ALB-408) und seine Verwendung
US8808319B2 (en) 2007-07-27 2014-08-19 Ethicon Endo-Surgery, Inc. Surgical instruments
US8882791B2 (en) 2007-07-27 2014-11-11 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US8430898B2 (en) 2007-07-31 2013-04-30 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US20090042253A1 (en) 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
GB0716047D0 (en) 2007-08-16 2007-09-26 Welding Inst Acoustic transducer assembley
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
EP2796102B1 (en) 2007-10-05 2018-03-14 Ethicon LLC Ergonomic surgical instruments
JP5119848B2 (ja) 2007-10-12 2013-01-16 富士ゼロックス株式会社 マイクロリアクタ装置
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US20100255573A1 (en) 2007-11-14 2010-10-07 Damian Joseph Peter Bond Extraction and purification of biologigal cells using ultrasound
US8096177B2 (en) 2007-11-19 2012-01-17 Petroleum Recovery Services Llc Fuel inventory monitoring system
ES2326109B1 (es) 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones.
US8030290B2 (en) 2007-12-07 2011-10-04 City Of Hope Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US9480935B2 (en) 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
KR20100128304A (ko) 2008-03-03 2010-12-07 쓰리엠 이노베이티브 프로퍼티즈 컴파니 가스 유동 시스템 내의 가청 음향 주파수 관리를 위한 방법
US8319398B2 (en) 2008-04-04 2012-11-27 Microsonic Systems Inc. Methods and systems to form high efficiency and uniform fresnel lens arrays for ultrasonic liquid manipulation
US8054145B2 (en) 2008-04-30 2011-11-08 Georgia Tech Research Corporation Phononic crystal wave structures
EP2285744A1 (en) 2008-05-27 2011-02-23 Kolmir Water Technologies Ltd. Apparatus and method for treatment of a contaminated water-based fluid
DE102008002210A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
CA2893175C (en) 2008-06-10 2016-09-06 Sangamo Biosciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
WO2009149519A1 (en) 2008-06-12 2009-12-17 Winwick Business Solutions Pty Ltd System for cultivation and processing of microorganisms and products therefrom
US7935259B2 (en) 2008-07-03 2011-05-03 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Filtering apparatus and method of use
EP2310486B1 (en) 2008-07-16 2017-01-04 kSep Systems, LLC Methods and systems for manipulating particles using a fluidized bed
MX2011000410A (es) 2008-07-18 2011-03-24 Prosonix Ltd Proceso para mejorar la cristalinidad de particulas de fluticasona.
US8387803B2 (en) 2008-08-26 2013-03-05 Ge Healthcare Bio-Sciences Ab Particle sorting
KR102178191B1 (ko) 2008-09-02 2020-11-13 머크 밀리포어 리미티드 크로마토그래피 막, 이를 포함하는 장치 및 이의 이용방법
JP2012501797A (ja) 2008-09-11 2012-01-26 ルナ イノベーションズ インコーポレイテッド 流体から気泡を音響学的に増強して除去する方法及び装置
US8865003B2 (en) 2008-09-26 2014-10-21 Abbott Laboratories Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended
SI2172211T1 (sl) 2008-10-01 2015-03-31 Immatics Biotechnologies Gmbh Sestavek s tumorjem povezanih peptidov in zadevnih cepiv proti raku za zdravljenje glioblastoma (GBM) in drugih vrst raka
EP2331230A1 (en) 2008-10-08 2011-06-15 FOSS Analytical A/S Separation of particles in liquids by use of a standing ultrasonic wave
US20100140185A1 (en) 2008-12-05 2010-06-10 John Hill Wastewater treatment
FR2941385B1 (fr) 2009-01-23 2011-04-01 Millipore Corp Procede pour fournir un circuit pour liquide biologique et circuit obtenu.
US20100206818A1 (en) 2009-02-19 2010-08-19 Chartered Semiconductor Manufacturing, Ltd. Ultrasonic filtration for cmp slurry
JP2010252785A (ja) 2009-03-31 2010-11-11 Kanagawa Acad Of Sci & Technol 細胞濃縮分離装置
WO2010117464A1 (en) 2009-04-09 2010-10-14 Sangamo Biosciences, Inc. Targeted integration into stem cells
US8476060B2 (en) 2009-04-13 2013-07-02 Board Of Regents, The University Of Texas System Process for separating lipids from a biomass
US20110095225A1 (en) 2009-04-20 2011-04-28 Origin Oil, Inc. Systems, apparatuses, and methods for extracting non-polar lipids from an aqueous algae slurry and lipids produced therefrom
IT1396003B1 (it) 2009-05-14 2012-11-09 Fidia Farmaceutici Ialuronidasi extracellulare da streptomyces koganeiensis
EP2436387B1 (en) 2009-05-25 2018-07-25 Celgene Corporation Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
US8865452B2 (en) 2009-06-15 2014-10-21 Aurora Algae, Inc. Systems and methods for extracting lipids from wet algal biomass
US8319400B2 (en) 2009-06-24 2012-11-27 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US8772004B2 (en) 2009-06-25 2014-07-08 Old Dominion University Research Foundation System and method for high-voltage pulse assisted aggregation of algae
CN102482690A (zh) 2009-06-26 2012-05-30 钴技术有限公司 生物产物生产的集成系统和方法
DE102009032840B4 (de) 2009-07-13 2015-02-05 Epcos Ag SAW-Filterschaltung mit verbesserter ESD-Festigkeit
GB0914762D0 (en) 2009-08-24 2009-09-30 Univ Glasgow Fluidics apparatus and fluidics substrate
EP2470638B1 (en) 2009-08-26 2019-10-23 GE Healthcare Bio-Sciences Corp. Continuous recovery harvest bag
GB0915072D0 (en) 2009-09-01 2009-09-30 Prokyma Technologies Ltd Ultrasound & magnetic method
US9532769B2 (en) 2009-09-04 2017-01-03 The University Of North Carolina At Chapel Hill Systems, methods, and computer readable media for high frequency contrast imaging and image-guided therapeutics
DE102009046145A1 (de) 2009-10-29 2011-05-12 Robert Bosch Gmbh Ultraschallwandler zum Einsatz in einem fluiden Medium
US9588121B2 (en) 2009-11-06 2017-03-07 Go Therapeutics, Inc. Method for early detection of cancer
US20180223439A1 (en) 2009-11-16 2018-08-09 Flodesign Sonics, Inc. Particle-particle interaction using acoustic waves
US8691145B2 (en) 2009-11-16 2014-04-08 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for water purification
EP3431608A3 (en) 2009-11-17 2019-02-20 E. R. Squibb & Sons, L.L.C. Method for enhanced protein production
US8663576B2 (en) 2009-11-25 2014-03-04 Hologic, Inc. Detection of intraamniotic infection
EP2507380A2 (en) 2009-12-03 2012-10-10 Bard Holding, Inc. Process and system for producing algal oil
US8518681B2 (en) 2009-12-04 2013-08-27 Sound Surgical Technologies Llc Selective lysing of cells using ultrasound
EP2507639B1 (en) 2009-12-04 2020-04-01 Life Technologies Corporation Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry
US8591459B2 (en) 2009-12-21 2013-11-26 Ethicon Endo-Surgery, Inc. Use of biomarkers and therapeutic agents with surgical devices
CA2792691A1 (en) 2010-03-11 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition or vaccine against gram-negative bacterial, for example, neisserial, infection or disease
US8722155B2 (en) 2010-03-12 2014-05-13 Los Alamos National Security, Llc Method to manufacture bit patterned magnetic recording media
GB201004551D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
EP2558179B1 (en) * 2010-04-12 2020-08-05 Flodesign Sonics Inc. Use of ultrasound and acoustophoresis technology for separation of particulates from a host medium
PT105058B (pt) 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
US8889388B2 (en) 2010-04-21 2014-11-18 Zhaowei Wang Acoustic device and methods thereof for separation and concentration
US8714360B2 (en) 2010-05-12 2014-05-06 Ethicon Endo-Surgery, Inc. Tissue processing device with ultrasonic tissue particle separator
JP5688451B2 (ja) 2010-06-04 2015-03-25 エンパイア テクノロジー ディベロップメント エルエルシー 音響的に駆動されるナノ粒子コンセントレータ
US8956538B2 (en) 2010-06-16 2015-02-17 Flodesign Sonics, Inc. Phononic crystal desalination system and methods of use
GB201010724D0 (en) 2010-06-25 2010-08-11 Isis Innovation Acoustic separators
US20130217113A1 (en) 2010-07-15 2013-08-22 Advanced Liquid Logic Inc. System for and methods of promoting cell lysis in droplet actuators
CA2993567C (en) 2010-07-21 2022-06-28 Sangamo Biosciences, Inc. Methods and compositions for modification of a t-cell receptor gene
US20130177500A1 (en) 2010-07-23 2013-07-11 Trustee Of Boston University Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
MX368531B (es) 2010-07-28 2019-10-07 Gliknik Inc Proteinas de fusion de fragmentos de proteinas humanas naturales para crear composiciones de fc de inmunoglobulinas multimerizadas ordenadamente.
WO2012015908A2 (en) 2010-07-30 2012-02-02 Millipore Corporation Chromatography media and method
ES2537207T3 (es) 2010-08-16 2015-06-03 Novimmune S.A. Métodos para la generación de anticuerpos multiespecíficos y multivalentes
US9011699B2 (en) 2010-08-23 2015-04-21 Flodesign Sonics, Inc. Ultrasonic agglomeration of microalgae
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
US8679338B2 (en) 2010-08-23 2014-03-25 Flodesign Sonics, Inc. Combined acoustic micro filtration and phononic crystal membrane particle separation
US8592204B2 (en) 2010-08-23 2013-11-26 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for collection and processing of oleaginous microorganisms
CA2811364C (en) 2010-09-27 2022-01-04 Sangamo Biosciences, Inc. Methods and compositions for inhibiting viral entry into cells
US20170233798A1 (en) 2010-10-22 2017-08-17 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
CN103209749B (zh) 2010-11-26 2015-04-22 英派尔科技开发有限公司 空气净化系统和使用超声波的方法
US9662375B2 (en) 2010-11-30 2017-05-30 Orphazyme Aps Methods for increasing intracellular activity of Hsp70
US8895279B2 (en) 2010-12-02 2014-11-25 Dennis A. Burke Applications of the rotating photobioreactor
EP2675540B1 (en) 2010-12-03 2018-03-21 GE Healthcare Bio-Sciences AB System and process for biopolymer chromatography
US20120145633A1 (en) 2010-12-09 2012-06-14 General Electric Company Ultra-sound enhanced centrifugal separation of oil from oily solids in water and wastewater
WO2012081931A2 (ko) 2010-12-17 2012-06-21 Kim Sung-Chun 세포배양을 통한 세포 및 지용성물질의 생산 방법 및 장치
GB2486680A (en) 2010-12-22 2012-06-27 Morgan Electro Ceramics Ltd Ultrasonic or acoustic transducer that supports two or more frequencies
US9314751B2 (en) 2011-01-07 2016-04-19 Life Technologies Corporation Methods and apparatus for mixing and shipping fluids
US9428565B2 (en) 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
US9810665B2 (en) 2011-02-04 2017-11-07 Cidra Corporate Services, Inc. Sonic filter for measuring and capturing particles having a particular particle size in a fluid, mixture or process flow
WO2012154237A1 (en) 2011-02-04 2012-11-15 Cidra Corporate Services Inc. Optimizing acoustic efficiency of a sonic filter or separator
US9480375B2 (en) 2011-02-09 2016-11-01 The University Of Vermont & State Agricultural College Aeroacoustic duster
ES2680636T3 (es) 2011-02-14 2018-09-10 Revivicor Inc. Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos
CA2828303C (en) 2011-02-28 2020-04-07 Seattle Children's Research Institute Coupling endonucleases with end-processing enzymes drive high efficiency gene disruption
WO2012135177A2 (en) 2011-03-29 2012-10-04 Uab Research Foundation Methods and compositions for cytomegalovirus il-10 protein
US20140115726A1 (en) 2011-04-05 2014-04-24 Cellectis New tale-protein scaffolds and uses thereof
EP2700975B1 (en) 2011-04-20 2023-04-05 Nissan Motor Co., Ltd. Mounting structure for sonar sensor
US8668886B2 (en) 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
CA2836460C (en) 2011-05-17 2021-09-21 Natrix Separations Inc. Methods of using a fluid treatment device
CN108659121A (zh) 2011-06-23 2018-10-16 埃博灵克斯股份有限公司 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术
EP3363812A1 (en) 2011-06-23 2018-08-22 Ablynx NV Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
JP2014520530A (ja) 2011-06-27 2014-08-25 フリアー システムズ, インコーポレイテッド 混合性核酸試料からの標的核酸の隔離
DE102011107533A1 (de) 2011-07-14 2013-01-17 Airbus Operations Gmbh Tür für ein Aufenthaltsmodul, Aufenthaltsmodul und Luftfahrzeug
FR2979256B1 (fr) 2011-08-30 2014-09-26 Centre Nat Rech Scient Dispositif de manipulation d'objets par champs de force acoustique
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A
NL1039052C2 (en) 2011-09-19 2013-03-21 Stichting Wetsus Ct Excellence Sustainable Water Technology Device and method for a heterogeneous waste water treatment reactor.
NL1039053C2 (en) 2011-09-19 2013-03-21 Stichting Wetsus Ct Excellence Sustainable Water Technology Device and method for a bioreactor, catalysis reactor or crystallizer without internals.
EP2761291B1 (en) 2011-09-28 2016-06-29 Acousort AB System and method to separate cells and/or particles
US9376655B2 (en) 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
US9175535B2 (en) 2011-09-29 2015-11-03 Coil Solutions, Inc. Propulsion generator and method
WO2013049623A1 (en) 2011-09-30 2013-04-04 Brian David Warner Fluid exchange methods and devices
ES2673957T5 (es) 2011-10-03 2021-12-15 Croda Int Plc Nanopartículas, procedimiento para la preparación y utilización de las mismas como portadoras de moléculas anfipáticas o hidrofóbicas en el campo de la medicina, incluyendo el tratamiento del cáncer, y compuestos de tipo alimentario
JP6435193B2 (ja) 2011-10-19 2018-12-05 ノビミューン エスアー 抗体を精製する方法
FR2982082B1 (fr) 2011-11-02 2013-11-22 Fabien Gaben Procede de fabrication de batteries en couches minces entierement solides
GB201119192D0 (en) 2011-11-07 2011-12-21 Ucl Business Plc Chromatography medium
JP6057251B2 (ja) 2011-11-11 2017-01-11 国立研究開発法人産業技術総合研究所 粒子分別装置および粒子分別方法
US8256076B1 (en) 2011-11-19 2012-09-04 Murray F Feller Method of making an ultrasonic transducer
GB201120143D0 (en) 2011-11-22 2012-01-04 Micromass Ltd Droplet manipulation using gas-phase standing-wave ultrasound fields in MS sources
WO2013075740A1 (en) 2011-11-23 2013-05-30 Sanofi Antibody purification method
EP2785743B1 (en) 2011-12-01 2019-08-14 The Brigham and Women's Hospital, Inc. Anti-ceacam1 recombinant antibodies for cancer therapy
GB201120887D0 (en) 2011-12-06 2012-01-18 The Technology Partnership Plc Acoustic sensor
WO2013091657A1 (en) 2011-12-22 2013-06-27 Herlev Hospital Therapeutic applications of calcium electroporation to effectively induce tumor necrosis
JP2015512766A (ja) 2012-01-31 2015-04-30 ザ・ペン・ステート・リサーチ・ファンデーション 可変定常的表面弾性波を用いたマイクロ流体操作及び粒子の分類
WO2013119880A1 (en) 2012-02-07 2013-08-15 Global Bio Therapeutics Usa, Inc. Compartmentalized method of nucleic acid delivery and compositions and uses thereof
GB2499251A (en) 2012-02-13 2013-08-14 Univ United Arab Emirates Treatment of industrial and petroleum refinery wastewater
ES2659941T3 (es) 2012-02-27 2018-03-20 Centre National De La Recherche Scientifique Método de formación de un agregado de células
CA2862756A1 (en) 2012-02-29 2013-09-06 Kci Licensing, Inc. Systems and methods for supplying reduced pressure and measuring flow using a disc pump system
CN104066990B (zh) 2012-03-07 2017-02-22 凯希特许有限公司 带有高级致动器的盘泵
WO2013138505A1 (en) 2012-03-13 2013-09-19 Salk Institute For Biological Studies Selective cell targeting using adenovirus and chemical dimers
AU2013231972B2 (en) 2012-03-14 2018-03-22 Salk Institute For Biological Studies Adenoviral tumor diagnostics
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
WO2013138797A1 (en) * 2012-03-15 2013-09-19 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
US20170191022A1 (en) 2012-03-15 2017-07-06 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US9340435B2 (en) 2012-03-15 2016-05-17 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9822333B2 (en) 2012-03-15 2017-11-21 Flodesign Sonics, Inc. Acoustic perfusion devices
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9950282B2 (en) * 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US10040011B2 (en) 2012-03-15 2018-08-07 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US9738866B2 (en) 2012-03-15 2017-08-22 Flodesign Sonics, Inc. Acoustic perfusion devices
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9623348B2 (en) 2012-03-15 2017-04-18 Flodesign Sonics, Inc. Reflector for an acoustophoretic device
US9797897B2 (en) 2012-03-26 2017-10-24 Duke University Acoustically responsive particles
PT106237B (pt) 2012-03-30 2015-03-19 Hovione Farmaci Ncia S A Produção de partículas substancialmente monodispersas utilizando moagem e separação por membranas
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
EP2833892A4 (en) 2012-04-02 2016-07-20 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS AND PEPTIDES ASSOCIATED WITH ONCOLOGY
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2838635A2 (en) 2012-04-20 2015-02-25 Flodesign Sonics Inc. Acoustophoretic enhanced system for use in tanks
RU2017113508A (ru) 2012-04-20 2019-01-28 Флоудизайн Соникс Инк. Акустофоретическая сепарация липидных частиц от эритроцитов
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
US9357293B2 (en) 2012-05-16 2016-05-31 Siemens Aktiengesellschaft Methods and systems for Doppler recognition aided method (DREAM) for source localization and separation
US9517474B2 (en) 2012-05-18 2016-12-13 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
CA2873791C (en) 2012-05-23 2016-12-13 Lanzatech New Zealand Limited A fermentation and simulated moving bed process
KR102247979B1 (ko) 2012-05-25 2021-05-04 셀렉티스 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법
JP2015519537A (ja) 2012-06-14 2015-07-09 ベリアブスキィ,ヤン エネルギー移動方法および装置
US9689802B2 (en) 2012-06-29 2017-06-27 Southwest Research Institute Systems, methods and apparatus for analysis of multiphase fluid mixture in pipelines
US9820768B2 (en) 2012-06-29 2017-11-21 Ethicon Llc Ultrasonic surgical instruments with control mechanisms
US9657290B2 (en) 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
US8709250B2 (en) 2012-07-12 2014-04-29 Heliae Development, Llc Tubular electro-acoustic aggregation device
EP2872234A1 (en) 2012-07-16 2015-05-20 Flodesign Sonics Inc. Improved separation of multi-component fluid through ultrasonic acoustophoresis
EP3494997B1 (en) 2012-07-25 2019-09-18 The Broad Institute, Inc. Inducible dna binding proteins and genome perturbation tools and applications thereof
WO2014022268A1 (en) 2012-08-01 2014-02-06 The Penn State Research Foundation High efficiency separation and manipulation of particles and cells
WO2014029505A1 (en) 2012-08-22 2014-02-27 Eth Zurich Acoustophoretic contactless transport and handling of matter in air
AU2013309488A1 (en) 2012-08-29 2015-03-05 Nature Technology Corporation DNA plasmids with improved expression
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
EP2897709B1 (en) 2012-09-21 2019-10-30 AcouSort AB A method for separating cells-bead complexes
JP2014079748A (ja) 2012-09-26 2014-05-08 Hitachi Ltd 超音波を用いた懸濁液処理装置
CA2887318C (en) * 2012-10-02 2021-07-27 Bart Lipkens Acoustophoretic separation technology using multi-dimensional standing waves
EP2906684B8 (en) 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
US9480991B2 (en) 2012-10-12 2016-11-01 Elwha Llc Radiofrequency particle separator
US9095367B2 (en) 2012-10-22 2015-08-04 Ethicon Endo-Surgery, Inc. Flexible harmonic waveguides/blades for surgical instruments
US10201365B2 (en) 2012-10-22 2019-02-12 Ethicon Llc Surgeon feedback sensing and display methods
WO2014066553A1 (en) 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
DE102012022146A1 (de) 2012-11-12 2014-05-15 Physik Instrumente (Pi) Gmbh & Co. Kg Ultraschallaktor für einen linearen Ultraschallmotor sowie linearer Ultraschallmotor mit einem Ultraschallaktor
US8900532B2 (en) 2012-11-16 2014-12-02 The Charles Stark Draper Laboratory, Inc. Apparatus and method for separating plasma from blood and delayed wetting
US9080167B2 (en) 2012-11-16 2015-07-14 Covaris, Inc. System and method for processing paraffin embedded samples
WO2014077863A1 (en) 2012-11-19 2014-05-22 Nature Technology Corporation Replicative minicircle vectors with improved expression
PL2735360T3 (pl) 2012-11-26 2017-09-29 Gambro Lundia Ab Urządzenie adsorbujące łączące granulki i membrany z włókien kanalikowych
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドModernaTX,Inc. 化学修飾mRNA
US9938390B2 (en) 2012-11-26 2018-04-10 Eth Zurich Method for the preparation of macroporous particles and macroporous microclusters
FR2998891B1 (fr) 2012-11-30 2015-04-10 Commissariat Energie Atomique Procede pour preparer un verre a porosite bimodale, eventuellement fonctionnalise et ledit verre
EP2928303A4 (en) 2012-12-07 2016-07-13 Haplomics Inc FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION
MX2015007550A (es) 2012-12-12 2017-02-02 Broad Inst Inc Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas.
EP2931892B1 (en) 2012-12-12 2018-09-12 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
US20140186843A1 (en) 2012-12-12 2014-07-03 Massachusetts Institute Of Technology Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
JP2016504050A (ja) 2013-01-17 2016-02-12 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド
US9504780B2 (en) 2013-01-30 2016-11-29 The Charles Stark Draper Laboratory, Inc. Extracorporeal clearance of organophosphates from blood on an acoustic separation device
CN107189933B (zh) 2013-02-07 2021-06-18 弗洛设计声能学公司 利用声驻波的生物反应器系统和相关方法
WO2014126548A1 (en) 2013-02-12 2014-08-21 Faurecia Emissions Control Technologies Vehicle exhaust system with resonance damping
CN105164535B (zh) 2013-02-14 2018-04-10 法龙药品公司 测定急性呼吸窘迫综合征(ards)相关生物标志物的方法、监测患者的ards的发展和治疗的方法
BR112015021098B1 (pt) 2013-03-01 2022-02-15 Ethicon Endo-Surgery, Inc Cobertura para uma junta de articulação e instrumento cirúrgico
US9554794B2 (en) 2013-03-01 2017-01-31 Ethicon Endo-Surgery, Llc Multiple processor motor control for modular surgical instruments
WO2014138203A2 (en) 2013-03-05 2014-09-12 Board Of Regents, The University Of Texas System Microfluidic devices for the rapid and automated processing of sample populations
JP5817762B2 (ja) * 2013-03-07 2015-11-18 ヤマハ株式会社 音響装置
WO2014138739A1 (en) 2013-03-08 2014-09-12 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
EP2970886B1 (en) 2013-03-12 2018-05-23 Sangamo Therapeutics, Inc. Methods and compositions for modification of hla
US9725709B2 (en) 2013-03-12 2017-08-08 OpenCell Technologies, Inc. Intracellular delivery and transfection methods and devices
US20140261535A1 (en) * 2013-03-13 2014-09-18 Lam Research Corporation Standing Wave Generation in Holes to Enhance Cleaning in the Holes in Liquid Sonification Cleaning Systems
WO2014152211A1 (en) 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US9388363B2 (en) 2013-03-15 2016-07-12 Megasonic Sweeping, Incorporated Ultrasonic and megasonic method for extracting palm oil
EP2975942B1 (en) 2013-03-21 2018-08-08 Sangamo Therapeutics, Inc. Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
AU2014245806B2 (en) 2013-03-28 2019-10-31 The University Of British Columbia Microfluidic devices and methods for use thereof in multicellular assays of secretion
AR095962A1 (es) 2013-04-01 2015-11-25 Moreinx Ab Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos
SG11201508804QA (en) 2013-04-25 2015-11-27 Flodesign Sonics Inc Excipient removal from pharmacological samples
RS61778B1 (sr) 2013-05-06 2021-06-30 Scholar Rock Inc Kompozicije i postupci za modulaciju faktora rasta
JP6463734B2 (ja) 2013-05-06 2019-02-06 サノフイSanofi 抗体を精製するための連続的多工程法
US9629877B2 (en) 2013-05-14 2017-04-25 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (CAR) T-cells
CN116083487A (zh) 2013-05-15 2023-05-09 桑格摩生物治疗股份有限公司 用于治疗遗传病状的方法和组合物
ES2883131T3 (es) 2013-05-29 2021-12-07 Cellectis Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
CA2913872C (en) 2013-05-31 2022-01-18 Cellectis A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof
JP6488283B2 (ja) 2013-05-31 2019-03-20 セレクティスCellectis C−cケモカイン受容体5型(ccr5)遺伝子を開裂するlaglidadgホーミングエンドヌクレアーゼおよびその用途
KR101442486B1 (ko) 2013-06-07 2014-09-24 아이에스테크놀로지 주식회사 초음파를 이용한 유체내 불순물 분리장치 및 분리방법
WO2014204723A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
US9725690B2 (en) 2013-06-24 2017-08-08 Flodesign Sonics, Inc. Fluid dynamic sonic separator
WO2015003012A2 (en) 2013-07-01 2015-01-08 Olivier Berteau Distributed perfusion bioreactor system for continuous culture of biological cells
CA2918036C (en) 2013-07-12 2018-04-24 Thomas J. Kennedy, Iii Acoustic bioreactor processes
ES2900004T3 (es) 2013-08-05 2022-03-15 Immatics Biotechnologies Gmbh Nueva inmunoterapia contra diversos tumores como el cáncer de pulmón, incluido el carcinoma de pulmón amicrocítico (NSCLC)
TWI777198B (zh) 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(七)
US11092521B2 (en) 2013-08-21 2021-08-17 Covaris, Inc. Method and system for acoustically treating material
CA2920899C (en) 2013-08-28 2023-02-28 Sangamo Biosciences, Inc. Compositions for linking dna-binding domains and cleavage domains
EP3043826A4 (en) 2013-09-13 2017-05-24 Moderna Therapeutics, Inc. Polynucleotide compositions containing amino acids
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
CN105899665B (zh) 2013-10-17 2019-10-22 桑格摩生物科学股份有限公司 用于核酸酶介导的基因组工程改造的递送方法和组合物
US10076574B2 (en) 2013-10-25 2018-09-18 Wayne State University Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
EP3065795A1 (en) 2013-11-05 2016-09-14 Flodesign Sonics Inc. Acoustophoresis device with modular components
AU2014346559B2 (en) 2013-11-07 2020-07-09 Editas Medicine,Inc. CRISPR-related methods and compositions with governing gRNAs
JP6530393B2 (ja) 2013-11-12 2019-06-12 ヴリジェ ユニヴェルシテ ブリュッセル Rna転写ベクター及びその使用
FR3012972A1 (fr) 2013-11-14 2015-05-15 Biomerieux Sa Nouveau milieu filtrant pour l'obtention de plasma, dispositif et procede de filtration associes
CA2930665A1 (en) 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
WO2015080901A1 (en) * 2013-11-26 2015-06-04 Celleration Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
DE102013224569B3 (de) 2013-11-29 2014-06-26 Physik Instrumente (Pi) Gmbh & Co. Kg Ultraschallmotor und Verfahren zum Betreiben eines solchen Ultraschallmotors
US20170173128A1 (en) 2013-12-06 2017-06-22 Moderna TX, Inc. Targeted adaptive vaccines
CN105899657A (zh) 2013-12-12 2016-08-24 布罗德研究所有限公司 用于改变基因产物表达的crispr-cas系统和方法、结构信息以及诱导型模块化cas酶
CN106536729A (zh) 2013-12-12 2017-03-22 布罗德研究所有限公司 使用粒子递送组分靶向障碍和疾病的crispr‑cas系统和组合物的递送、用途和治疗应用
GB201322103D0 (en) 2013-12-13 2014-01-29 The Technology Partnership Plc Fluid pump
DE102013226418B3 (de) 2013-12-18 2015-04-02 Physik Instrumente (Pi) Gmbh & Co. Kg Ultraschallmotor
EP3083691A2 (en) 2013-12-20 2016-10-26 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
US20160312168A1 (en) 2013-12-30 2016-10-27 Ge Healthcare Bio-Sciences Corp. Apparatus for cell cultivation
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US20170002060A1 (en) 2014-01-08 2017-01-05 Moderna Therapeutics, Inc. Polynucleotides for the in vivo production of antibodies
US9567846B2 (en) * 2014-01-09 2017-02-14 Baker Hughes Incorporated Devices and methods for downhole acoustic imaging
US20160332159A1 (en) 2014-01-15 2016-11-17 Eth Zurich Acoustophoretic droplet handling in bulk acoustic wave devices
US9878536B2 (en) 2014-01-24 2018-01-30 President And Fellows Of Harvard College Acoustophoretic printing apparatus and method
EP3107552B1 (en) 2014-02-21 2018-03-28 Cellectis Method for in situ inhibition of regulatory t cells
CN106414702A (zh) 2014-03-10 2017-02-15 弗洛设计声能学公司 具有声致泳动设备的一次性生物反应器
KR102228828B1 (ko) 2014-03-11 2021-03-16 셀렉티스 동종이형 이식에 양립성인 t-세포들을 만들어내는 방법
US8820538B1 (en) 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
DK3569619T3 (da) 2014-03-19 2021-06-14 Cellectis Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi
WO2015143335A1 (en) 2014-03-20 2015-09-24 The University Of North Carolina At Chapel Hill Methods and compositions for chimeric coronavirus spike proteins
EP3129484A1 (en) 2014-03-25 2017-02-15 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating hiv infection and aids
DE102014205577B4 (de) 2014-03-26 2021-05-12 Physik Instrumente (Pi) Gmbh & Co. Kg Ultraschallmotor
US9982265B2 (en) 2014-03-28 2018-05-29 Board Of Regents, The University Of Texas System Inhibition of Bruton's tyrosine kinase (Btk) in the lung to treat severe lung inflammation and lung injury
WO2015148842A1 (en) 2014-03-28 2015-10-01 The Regents Of The University Of California Efficient delivery of large cargos into cells on a porous substrate
US10047650B2 (en) 2014-03-31 2018-08-14 Faurencia Emissions Technologies USA, LLC Vehicle exhaust system with resistive patch
CA2944492A1 (en) 2014-04-01 2015-10-08 Rubius Therapeutics, Inc. Methods and compositions for immunomodulation
WO2015153789A1 (en) 2014-04-01 2015-10-08 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
DK3126390T3 (da) 2014-04-03 2020-01-20 Cellectis Cd33-specifikke kimære antigenreceptorer til cancerimmunterapi
DE102014206823A1 (de) 2014-04-09 2015-10-15 Siemens Aktiengesellschaft Vorrichtung zum Trennen einer Emulsion und/oder einer Suspension
US10765728B2 (en) 2014-04-11 2020-09-08 Cellectis Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
JP6698546B2 (ja) 2014-04-14 2020-05-27 セレクティスCellectis 癌免疫療法のためのbcma(cd269)特異的キメラ抗原受容体
BR112016024644A2 (pt) 2014-04-23 2017-10-10 Modernatx Inc vacinas de ácido nucleico
CN106459924A (zh) 2014-04-23 2017-02-22 得克萨斯州大学系统董事会 用于疗法中的嵌合抗原受体(car)及其制备方法
WO2015164829A1 (en) 2014-04-24 2015-10-29 New Jersey Institute Of Technology Concealed fastener window or curtain wall assemblies
WO2015171691A2 (en) 2014-05-06 2015-11-12 Scholar Rock, Inc. Compositions and methods for growth factor modulation
EP3140387A1 (en) 2014-05-08 2017-03-15 Flodesign Sonics Inc. Acoustophoretic device with piezoelectric transducer array
CN106459914B (zh) 2014-05-15 2020-11-06 新加坡国立大学 经修饰的自然杀伤细胞及其用途
CN106536059B (zh) 2014-06-09 2019-01-11 阿森特生物纳米科技股份有限公司 用于颗粒的控制和分拣系统
GB201410262D0 (en) 2014-06-10 2014-07-23 Cambridge Entpr Ltd Novel method
US9683968B2 (en) * 2014-06-17 2017-06-20 Nxp B.V. Combination sensor
US10000533B2 (en) 2014-06-20 2018-06-19 Immatics Biotechnologies Gmbh Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)
WO2016004398A2 (en) 2014-07-02 2016-01-07 Flodesign Sonics, Inc. Acoustophoretic device with uniform fluid flow
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
ES2726671T3 (es) 2014-07-14 2019-10-08 Westinghouse Electric Co Llc Conjunto de medición termoacústica de la distribución de potencia nuclear
US9605266B2 (en) 2014-07-16 2017-03-28 City Of Hope Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
US10432112B2 (en) 2014-07-23 2019-10-01 Physik Instrumente (Pi) Gmbh &. Co. Kg Ultrasonic motor
AU2015295349B2 (en) 2014-07-29 2020-09-24 Cellectis ROR1(NTRKR1)specific chimeric antigen receptors for cancer immunotherapy
US9908288B2 (en) 2014-07-29 2018-03-06 The Boeing Company Free-form spatial 3-D printing using part levitation
WO2016019144A2 (en) 2014-07-30 2016-02-04 Sangamo Biosciences, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
WO2016022851A1 (en) 2014-08-06 2016-02-11 Children's Medical Center Corporation Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof
US20170232439A1 (en) 2014-08-11 2017-08-17 Carnegie Mellon University Separation of low-abundance cells from fluid using surface acoustic waves
WO2016028682A1 (en) 2014-08-17 2016-02-25 The Broad Institute Inc. Genome editing using cas9 nickases
HUE043847T2 (hu) 2014-08-28 2019-09-30 Halozyme Inc Hialuronán-lebontó enzimmel és egy immun checkpoint inhibitorral végzett kombinációs terápia
US20160060615A1 (en) 2014-09-03 2016-03-03 Thomas Walther Device for the identification, separation and / or cell type-specific manipulation of at least one cell of a cellular system
WO2017039709A1 (en) * 2015-09-04 2017-03-09 Edison Industrial Innovation, Llc Closed-loop metalworking system
US20160082129A1 (en) 2014-09-24 2016-03-24 Aerpio Therapeutics, Inc. VE-PTP Extracellular Domain Antibodies Delivered by a Gene Therapy Vector
WO2016049251A1 (en) 2014-09-24 2016-03-31 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
WO2016049258A2 (en) 2014-09-25 2016-03-31 The Broad Institute Inc. Functional screening with optimized functional crispr-cas systems
US9675906B2 (en) 2014-09-30 2017-06-13 Flodesign Sonics, Inc. Acoustophoretic clarification of particle-laden non-flowing fluids
AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
US10238741B2 (en) 2014-10-10 2019-03-26 The Trustees Of Columbia University In The City Of New York Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof
EA201700181A1 (ru) 2014-10-14 2017-09-29 Галозим, Инк. Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования
WO2016065249A1 (en) 2014-10-24 2016-04-28 Life Technologies Corporation Acoustically settled liquid-liquid sample purification system
CN107110765B (zh) 2014-11-03 2020-10-02 通用医疗公司 在微流体装置中浓缩颗粒
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US20160142832A1 (en) * 2014-11-19 2016-05-19 Martin Evert Gustaf Hillbratt Signal Amplifier
US20160153249A1 (en) 2014-12-02 2016-06-02 Chevron U.S.A. Inc. Systems and Methods for Reducing Pipeline Erosion Using Acoustic Radiation
AU2015360502A1 (en) 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
DK3035519T3 (en) 2014-12-19 2018-06-06 Attocube Systems Ag Electromechanical actuator
GB201501017D0 (en) 2014-12-23 2015-03-04 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
EP3245001B1 (en) 2015-01-12 2024-06-12 Instrumentation Laboratory Company Spatial separation of particles in a particle containing solution for biomedical sensing and detection
JP6901404B2 (ja) 2015-01-21 2021-07-14 ユタ バレー ユニバーシティ 空間的な収束、操作、およびパターニングのための定在波場の高調波変調用システムおよび方法
EP3250605A1 (en) 2015-01-26 2017-12-06 Cellectis Anti-hsp70 specific chimeric antigen receptors (cars) for cancer immunotherapy
DE102015101542A1 (de) 2015-02-03 2016-08-18 ACO Severin Ahlmann GmbH & Co Kommanditgesellschaft Verfahren und Vorrichtung zur Abtrennung von Stoffen
CN104785429B (zh) * 2015-02-03 2017-01-11 浙江工业大学 一种具有声反馈功能的压电式超声换能器
CN107635581A (zh) 2015-02-13 2018-01-26 赛诺菲 用于单克隆抗体的稳定液体制剂
US20160237110A1 (en) 2015-02-16 2016-08-18 Flodesign Sonics, Inc. Acoustic microreactor and methods of use thereof
US20180246103A1 (en) 2015-02-16 2018-08-30 Flodesign Sonics, Inc. Acoustic microreactor and methods of use thereof
WO2016134115A1 (en) 2015-02-20 2016-08-25 Trustees Of Boston University Theranostic compositions and uses thereof
US10324082B2 (en) 2015-03-03 2019-06-18 Quest Diagnostics Investments Llc Methods for quantitation of insulin levels by mass spectrometry
AR103852A1 (es) 2015-03-06 2017-06-07 Genentech Inc DsbA Y DsbC ULTRAPURIFICADOS Y SUS MÉTODOS DE PREPARACIÓN Y USO
NL2014433B1 (nl) 2015-03-10 2016-10-13 Exsilent Res Bv Persoonlijke gehoorinrichting, in het bijzonder een hoortoestel.
US10570382B2 (en) 2015-03-11 2020-02-25 Board Of Regents, The University Of Texas System Transposase polypeptides and uses thereof
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
WO2016154475A1 (en) 2015-03-24 2016-09-29 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
WO2016154578A1 (en) 2015-03-25 2016-09-29 Eta Diagnostics, Inc. An optical cell constructed by anodically bonding a thin metal layer between two optically clear glass windows
CN104722106B (zh) 2015-03-25 2016-04-06 陕西师范大学 一种细微颗粒的超声分离装置
WO2016154596A1 (en) 2015-03-25 2016-09-29 Editas Medicine, Inc. Crispr/cas-related methods, compositions and components
WO2016154579A2 (en) 2015-03-26 2016-09-29 Editas Medicine, Inc. Crispr/cas-mediated gene conversion
US20180071981A1 (en) 2015-03-31 2018-03-15 The Regents Of The University Of California System and method for tunable patterning and assembly of particles via acoustophoresis
US10737012B2 (en) 2015-03-31 2020-08-11 Biomet Biologics, Inc. Cell washing using acoustic waves
US9855382B2 (en) 2015-03-31 2018-01-02 Biomet Biologics, Llc Cell washing device using standing acoustic waves and a phantom material
US10794865B2 (en) 2015-04-01 2020-10-06 Triad National Security, Llc Ultrasonic in-situ water-cut measurement using ultrasonic oil-water separation for affecting sound speed calibration
US20180095067A1 (en) 2015-04-03 2018-04-05 Abbott Laboratories Devices and methods for sample analysis
CA2982365A1 (en) 2015-04-17 2016-10-20 Xcell Biosciences, Inc. Cancer cell enrichment system
US20180066223A1 (en) 2015-04-17 2018-03-08 Xcell Biosciences, Inc. Cancer cell enrichment system
US10900902B2 (en) 2015-04-20 2021-01-26 Unm Rainforest Innovations Method for simultaneous spectrally resolved detection or imaging of items in multiple flowing streams
US9947431B2 (en) 2015-04-21 2018-04-17 The Florida International University Board Of Trustees Anisotropic films templated using ultrasonic focusing
CA2983293C (en) 2015-04-24 2023-06-20 The Regents Of The University Of California Modulators of ror1-ror2 binding
CA2984492A1 (en) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Acoustophoretic device for angled wave particle deflection
US10640760B2 (en) 2016-05-03 2020-05-05 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
PT3289362T (pt) 2015-04-30 2022-06-21 European Molecular Biology Laboratory Deteção e classificação de gotas microfluídicas
WO2016176611A2 (en) 2015-04-30 2016-11-03 Wilsa Holding, Llc Method and apparatus for conditioning fluids
WO2016178167A1 (en) 2015-05-04 2016-11-10 Vcn Biosciences Sl Oncolytic adenoviruses with mutations in immunodominant adenovirus epitopes and their use in cancer treatment
WO2016179564A1 (en) 2015-05-06 2016-11-10 Flodesign Sonics, Inc. Acoustic pre-conditioner
US10414810B2 (en) 2015-05-07 2019-09-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Double mutant survivin vaccine
CN107708761B (zh) 2015-05-07 2022-04-29 艾尼蒂斯科技公司 使用相应方法分离血液的封闭式一次性无菌多血袋系统
WO2017191289A1 (en) 2016-05-04 2017-11-09 Aenitis Technologies Multiple blood bag system
EP3015542A1 (de) 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
EP3294888A1 (en) 2015-05-11 2018-03-21 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating hiv infection and aids
WO2016182959A1 (en) 2015-05-11 2016-11-17 Editas Medicine, Inc. Optimized crispr/cas9 systems and methods for gene editing in stem cells
WO2016180918A1 (en) 2015-05-12 2016-11-17 Platod Combination of pharmacological and microfluidic features for improved platelets production
EP3037513A1 (de) 2015-05-13 2016-06-29 Bayer Technology Services GmbH Verfahren zur kontinuierlichen elution eines produktes von chromatographiesäulen
AU2016262093B2 (en) 2015-05-13 2022-08-18 Seattle Children' S Hospital (Dba Seattle Children 's Research Institute) Enhancing endonuclease based gene editing in primary cells
CN104892672B (zh) 2015-05-15 2018-09-21 浙江九洲药业股份有限公司 手性螺环膦-氮-硫三齿配体及其制备方法和应用
PT3294764T (pt) 2015-05-15 2021-02-15 Hope City Composições de recetores de antigénios quiméricos
KR102603273B1 (ko) 2015-05-20 2023-11-16 프로디자인 소닉스, 인크. 정재파장에서 입자의 음향 조작
EP3298046A1 (en) 2015-05-20 2018-03-28 Cellectis Anti-gd3 specific chimeric antigen receptors for cancer immunotherapy
US9686096B2 (en) 2015-05-20 2017-06-20 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
CN107614097B (zh) 2015-05-27 2020-02-14 联邦科学与工业研究组织 金属-有机框架的生产
WO2016187669A1 (en) 2015-05-27 2016-12-01 Commonwealth Scientific And Industrial Research Organisation Separation of metal-organic frameworks
EP3303558B1 (en) 2015-05-29 2022-05-25 Boehringer Ingelheim International GmbH Cell-controlled perfusion in continuous culture
US20180148763A1 (en) 2015-06-01 2018-05-31 Shimadzu Corporation Method for quantifying monoclonal antibody
EP3307774A1 (en) 2015-06-09 2018-04-18 Institut Pasteur Monoclonal antibodies specific for serogroup x of n. meningitidis and uses thereof in diagnosis
US10161926B2 (en) 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
RU2752834C2 (ru) 2015-06-18 2021-08-09 Те Брод Инститьют, Инк. Мутации фермента crispr, уменьшающие нецелевые эффекты
AU2016279062A1 (en) 2015-06-18 2019-03-28 Omar O. Abudayyeh Novel CRISPR enzymes and systems
EP3666895A1 (en) 2015-06-18 2020-06-17 The Broad Institute, Inc. Novel crispr enzymes and systems
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
EP3311173A2 (en) 2015-06-18 2018-04-25 Thomas Mole Herd Methods of characterising cancer
US10648020B2 (en) 2015-06-18 2020-05-12 The Broad Institute, Inc. CRISPR enzymes and systems
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
US9613615B2 (en) 2015-06-22 2017-04-04 Sony Corporation Noise cancellation system, headset and electronic device
EP3310848A1 (en) 2015-06-22 2018-04-25 Proxonix AS Method for making a body with arranged particles using acoustic waves
US11129669B2 (en) 2015-06-30 2021-09-28 Cilag Gmbh International Surgical system with user adaptable techniques based on tissue type
US9368110B1 (en) 2015-07-07 2016-06-14 Mitsubishi Electric Research Laboratories, Inc. Method for distinguishing components of an acoustic signal
JP5923205B1 (ja) 2015-07-07 2016-05-24 日立アロカメディカル株式会社 超音波探触子
EP3319739B1 (en) 2015-07-09 2021-03-31 Flodesign Sonics Inc. Non-planar and non-symmetrical piezolectric crystals and reflectors
EP3322297A4 (en) 2015-07-13 2019-04-17 Sangamo Therapeutics, Inc. RELEASE METHOD AND COMPOSITIONS FOR NUCLEASE-DERIVED GENOMINE ENGINEERING
JP2018527903A (ja) 2015-07-22 2018-09-27 スカラー ロック インコーポレイテッドScholar Rock,Inc. Gdf11結合タンパク質およびその使用
CA3005845A1 (en) 2015-07-28 2017-02-02 Flodesign Sonics, Inc. Acoustic affinity separation
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
CN108472314A (zh) 2015-07-31 2018-08-31 明尼苏达大学董事会 修饰的细胞和治疗方法
EP3332160B1 (en) 2015-08-03 2023-09-27 Arlenko Pty Ltd Fire collar
CN105087788B (zh) 2015-08-03 2018-11-23 上海白泽医疗器械有限公司 一种分选人细胞的免疫磁珠、其制备及切除方法
EP3331993A1 (en) 2015-08-05 2018-06-13 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Use of dermatopontin for maintaining hematopoietic stem and/or progenitor cells in culture
WO2017027519A1 (en) 2015-08-11 2017-02-16 Apocell, Inc. Systems and methods for isolating target particles and their use in diagnostic, prognostic, and therapeutic, methods
CN105384825B (zh) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
US10261078B2 (en) 2015-08-17 2019-04-16 National Technology & Engineering Solutions Of Sandia, Llc Shear horizontal surface acoustic wave (SH-SAW) resonators and arrays thereof
JP7091238B2 (ja) 2015-08-20 2022-06-27 ジェネンテック, インコーポレイテッド Fkpaの精製、及び組換えポリペプチドの産生のためのその使用
WO2017032777A1 (en) 2015-08-24 2017-03-02 Cellectis Chimeric antigen receptors with integrated controllable functions
WO2017035249A1 (en) 2015-08-24 2017-03-02 Trustees Of Boston University ANTI-DEspR MONOCLONAL ANTIBODY TARGETED THERAPY AND IMAGING FOR CANCER AND STROKE
LT3341116T (lt) 2015-08-27 2022-05-25 President And Fellows Of Harvard College Rūšiavimo naudojant akustines bangas būdas
GB201515339D0 (en) 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
US9947514B2 (en) * 2015-09-01 2018-04-17 Mks Instruments, Inc. Plasma RF bias cancellation system
JP2018526013A (ja) 2015-09-01 2018-09-13 イネイト・テューマー・イミュニティ・インコーポレイテッドInnate Tumor Immunity, Inc. 免疫または免疫抑制性サイトカインに対する抵抗性が増大した免疫細胞およびその使用
WO2017041102A1 (en) 2015-09-04 2017-03-09 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
WO2017044864A1 (en) 2015-09-09 2017-03-16 Revivicor, Inc Multi-transgenic pig for xenotransplantation
EP3347098B1 (en) 2015-09-09 2022-01-05 Virginia Commonwealth University Targeting mda-5 activation for cancer immunotherapy
US10155222B2 (en) 2015-09-17 2018-12-18 Carnegie Mellon University Device for the separation of particles using a bulk acoustic wave field
US20190054112A1 (en) 2015-09-18 2019-02-21 Moderna Therapeutics, Inc. Polynucleotide formulations for use in the treatment of renal diseases
CN106554010A (zh) 2015-09-25 2017-04-05 苏州烯时代石墨烯科技有限公司 工业化制备大尺寸石墨烯的方法
USD787630S1 (en) 2015-10-06 2017-05-23 Flodesign Sonics, Inc. U-turn acoustic separation device
KR102549704B1 (ko) 2015-10-07 2023-06-30 후지레비오 가부시키가이샤 Pivka-ii의 측정 방법, 및 pivka-ii 면역측정 시약 또는 키트의 제조 방법
US10224015B2 (en) 2015-10-09 2019-03-05 Jeffrey James Hsu Stringless bowed musical instrument
EP3386652B1 (en) 2015-10-14 2022-06-22 Sonosep Technologies Inc. Methods, systems, and apparatuses for acoustically separating and washing particles
EP3362102A1 (en) 2015-10-14 2018-08-22 Life Technologies Corporation Ribonucleoprotein transfection agents
WO2017070110A1 (en) 2015-10-19 2017-04-27 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
CA3001351A1 (en) 2015-10-21 2017-04-27 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating hepatitis b virus
EP3365441A1 (en) 2015-10-22 2018-08-29 The Broad Institute Inc. Type vi-b crispr enzymes and systems
BR112018008250B1 (pt) 2015-10-23 2022-10-04 3M Innovative Properties Company Sequência de meio filtrante, dispositivo filtrante e método de fabricação de um fluido biológico
TW201729810A (zh) 2015-10-26 2017-09-01 札爾科製藥公司 嘧啶組成物、其超純組成物及鹽類、製造彼之方法、及使用彼於治療組織胺h4受體(h 4 )仲介之疾病與病情之方法
JP7408284B2 (ja) 2015-10-30 2024-01-05 エディタス・メディシン、インコーポレイテッド 単純ヘルペスウイルスを治療するためのcrispr/cas関連方法及び組成物
WO2017079674A1 (en) 2015-11-04 2017-05-11 Northeastern University Systems for producing cellular immunotherapeutics and methods of use thereof
CN105307099B (zh) * 2015-11-11 2018-10-02 西安工程大学 一种扬声器功率试验系统及功率和低频参数的测试方法
SG10201509280YA (en) 2015-11-11 2017-06-29 Singapore Univ Of Tech And Design Microfluidic particle manipulation
US9910074B2 (en) * 2015-11-12 2018-03-06 National Instruments Corporation Digital approach to the removal of AC parasitics for impedance measurements
WO2017083681A1 (en) 2015-11-13 2017-05-18 The University Or North Carolina At Chapel Hill Optimized crosslinkers for trapping a target on a substrate
JP2019506143A (ja) 2015-12-14 2019-03-07 ベリカム ファーマシューティカルズ, インコーポレイテッド 治療用細胞の活性化及び排除のための二重コントロール
EP3359676B1 (en) 2015-12-14 2021-02-24 GenomeFrontier Therapeutics, Inc. Transposon system, kit comprising the same, and uses thereof
US10648460B2 (en) 2015-12-16 2020-05-12 The University Of Hong Kong Nanomotor propulsion
US11053788B2 (en) 2015-12-16 2021-07-06 Saudi Arabian Oil Company Acoustic downhole oil-water separation
JP7065036B2 (ja) 2015-12-17 2022-05-11 モダーナティエックス・インコーポレイテッド メチルマロニルCoAムターゼをコードするポリヌクレオチド
EA201891212A1 (ru) 2015-12-18 2019-01-31 Сангамо Терапьютикс, Инк. Адресная дезорганизация клеточного рецептора гкгс
SI3394266T1 (sl) 2015-12-22 2021-08-31 Xl-Protein Gmbh Nukleinske kisline, ki kodirajo ponavljajoča se aminokislinska zaporedja, bogata s prolinskimi in alaninskimi ostanki, ki imajo manj ponavljajočih se nukleotidnih zaporedij
US10648900B2 (en) 2015-12-23 2020-05-12 Becton, Dickinson And Company Multi-color flow cytometric analysis of samples with low cell numbers
BR112018013065A2 (pt) 2015-12-28 2018-12-11 Intellia Therapeutics Inc composições e métodos para o tratamento de hemoglobinopatias
CA3010612A1 (en) 2016-01-08 2017-07-13 Oncobiologics, Inc. Methods for separating isoforms of monoclonal antibodies
US10428324B1 (en) 2016-01-08 2019-10-01 Triad National Security, Llc Acoustic manipulation of fluids based on eigenfrequency
GB201600328D0 (en) 2016-01-08 2016-02-24 Univ Oslo Hf Anti-CD37 chimeric antigen receptors and immune cells expressing them
KR20180096793A (ko) 2016-01-14 2018-08-29 안톤 바우어 생산 세포주를 제조하는 방법
US10842523B2 (en) 2016-01-15 2020-11-24 Ethicon Llc Modular battery powered handheld surgical instrument and methods therefor
KR20180101540A (ko) 2016-01-15 2018-09-12 이투빅스 코포레이션 T 세포 면역요법을 위한 방법 및 조성물
WO2017127686A1 (en) 2016-01-22 2017-07-27 Carnegie Mellon University Three-dimensional acoustic manipulation of cells
US10973852B2 (en) 2016-01-25 2021-04-13 Nantcell, Inc. NK cells with altered CXCL12/CXCR4 signaling
US20190031780A1 (en) 2016-01-27 2019-01-31 Siamab Therapeutics, Inc. Compositions and methods for targeting cancer stem cells
WO2017133175A1 (en) 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
WO2017148928A1 (en) 2016-03-01 2017-09-08 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Means and methods for treating herpesvirus infection
WO2017152015A1 (en) 2016-03-04 2017-09-08 Editas Medicine, Inc. Crispr-cpf1-related methods, compositions and components for cancer immunotherapy
CA3016841A1 (en) 2016-03-06 2017-09-14 WindplusSonne GmbH Method and device for separating and/or cleaning aerosols and solid material particles and fibers from gases as well as solid material particles and fibers from liquid materials by acoustophoresis
US11497781B2 (en) 2016-03-10 2022-11-15 Cg Oncology, Inc. Methods of treating bladder cancer by combination therapy comprising the oncolytic adenovirus CG0070 and an immune checkpoint inhibitor
BR112018068354A2 (pt) 2016-03-11 2019-01-15 Bluebird Bio Inc células efetoras imunológicas do genoma editado
WO2017161384A1 (en) 2016-03-12 2017-09-21 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
WO2017160964A1 (en) 2016-03-15 2017-09-21 Washington University High throughput acoustic particle separation methods and devices
CA3015162A1 (en) 2016-03-15 2017-09-21 Cancer Research Technology Limited Antibodies and related molecules and uses thereof
WO2017157426A1 (en) 2016-03-15 2017-09-21 Centre National De La Recherche Scientifique Acoustic tweezers
EP3219800A1 (en) 2016-03-15 2017-09-20 Max-Delbrück-Centrum Für Molekulare Medizin A transposon-based transfection system for primary cells
WO2017160991A1 (en) 2016-03-16 2017-09-21 Lavieu Gregory G Methods, systems and devices for selection and generation of genome edited clones
CN108779469A (zh) 2016-03-25 2018-11-09 基因体先驱生医股份有限公司 用以建构转位子的套组及其用途
EP3433363A1 (en) 2016-03-25 2019-01-30 Editas Medicine, Inc. Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
WO2017172644A2 (en) 2016-03-28 2017-10-05 The Charles Stark Draper Laboratory, Inc. Bacteria identification and antibiotic susceptibility profiling device
WO2017173005A1 (en) 2016-03-30 2017-10-05 Sapphire Energy, Inc. Modified rubisco large subunit proteins
WO2017173384A1 (en) 2016-04-01 2017-10-05 Kite Pharma, Inc. Chimeric receptors and methods of use thereof
US20190119387A1 (en) 2016-04-05 2019-04-25 Glaxosmithkline Intellectual Property Development Limited Inhibition of tgfbeta in immunotherapy
SG11201808705XA (en) 2016-04-06 2018-11-29 Univ Singapore Technology & Design Particle manipulation
CA3020330A1 (en) 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
WO2017180665A2 (en) 2016-04-12 2017-10-19 Edward Perkins Methods for creatings synthetic chromosomes expressing biosynthetic pathways and uses thereof
RU2018139465A (ru) 2016-04-12 2020-05-13 СИНПЛОЙД БАЙОТЕК, ЭлЭлСи Способы создания синтетических хромосом, имеющих генные регуляторные системы, и их применение
US10932829B2 (en) 2016-04-14 2021-03-02 Orthoxel Dac Intramedullary nail system
CA3020993A1 (en) 2016-04-14 2017-10-19 Bluebird Bio, Inc. Salvage chimeric antigen receptor systems
KR102670601B1 (ko) 2016-04-19 2024-05-29 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
US11286478B2 (en) 2016-04-19 2022-03-29 The Broad Institute, Inc. Cpf1 complexes with reduced indel activity
WO2017189308A1 (en) 2016-04-19 2017-11-02 The Broad Institute Inc. Novel crispr enzymes and systems
KR102529012B1 (ko) 2016-04-22 2023-05-09 크라제 메디컬 씨오 리미티드 세포성 면역요법을 위한 조성물 및 방법
WO2017186718A1 (en) 2016-04-25 2017-11-02 Universität Basel Allele editing and applications thereof
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
EP3452499A2 (en) 2016-05-06 2019-03-13 Juno Therapeutics, Inc. Genetically engineered cells and methods of making the same
MA45041A (fr) 2016-05-18 2019-03-27 Modernatx Inc Polynucléotides codant pour la galactose-1-phosphate uridylyltransférase destinés au traitement de la galactosémie de type 1
EP3458107B1 (en) 2016-05-18 2024-03-13 ModernaTX, Inc. Polynucleotides encoding jagged1 for the treatment of alagille syndrome
MY201498A (en) 2016-05-18 2024-02-27 Modernatx Inc Polynucleotides encoding citrin for the treatment of citrullinemia type 2
MA45053A (fr) 2016-05-18 2019-03-27 Modernatx Inc Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique
CA3024507A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding .alpha.-galactosidase a for the treatment of fabry disease
CA3024624A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
SI3458083T1 (sl) 2016-05-18 2023-03-31 Modernatx, Inc. Polinukleotidi, ki kodirajo interlevkin-12 (IL12) in njihova uporaba
US20200316586A1 (en) 2016-05-24 2020-10-08 Centre National De La Recherche Scientifique Acoustic tweezers
EP3463433A1 (en) 2016-05-25 2019-04-10 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and compositions for treating cancers
WO2017207589A1 (en) 2016-06-01 2017-12-07 Kws Saat Se Hybrid nucleic acid sequences for genome engineering
US10829402B2 (en) 2016-06-07 2020-11-10 Evoqua Water Technologies Llc Ballasted solids treatment system and method
US10212514B2 (en) * 2016-06-10 2019-02-19 Cirrus Logic, Inc. Method for limiting amplifier input current to avoid low voltage conditions
WO2017218519A1 (en) 2016-06-13 2017-12-21 Bluebird Bio, Inc. Gene therapy of neuronal ceroid lipofuscinoses
EP3468351B1 (en) 2016-06-13 2020-09-09 Lic Automation Limited A livestock management system and method of operation
CN114176043B (zh) 2016-06-14 2024-04-23 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
EP3257600A1 (en) 2016-06-15 2017-12-20 Maquinaria GEKA, S.A. Notching tool, use and method
WO2017222777A1 (en) 2016-06-21 2017-12-28 Becton, Dickinson And Company Devices and methods for acoustic particle separation
US10800899B2 (en) 2016-06-22 2020-10-13 Yunuen Montelongo Reversible optical assembly of composites
WO2017220767A1 (en) 2016-06-24 2017-12-28 Sciencons AS Preparation of 212pb labeled monoclonal antibodies
WO2018002036A1 (en) 2016-06-28 2018-01-04 Zaklady Farmaceutyczne Polpharma Sa Recombinant production of monoclonal antibodies
US20180015128A1 (en) 2016-06-29 2018-01-18 Applied Biologics, Llc Amniotic Fluid-Derived Preparation with a Standardized Biologic Activity
US20180000870A1 (en) 2016-06-29 2018-01-04 Applied Biologics, Llc Methods of forming amniotic fluid-derived preparations
US20210222164A1 (en) 2016-06-29 2021-07-22 The Broad Institute, Inc. Crispr-cas systems having destabilization domain
KR102496333B1 (ko) 2016-06-30 2023-02-07 삼성전자주식회사 식기 세척기 및 그 제어 방법
US20180003110A1 (en) 2016-07-01 2018-01-04 Flodesign Sonics, Inc. Acoustically-Enhanced Separators for Aircraft Engines
US20180010117A1 (en) 2016-07-07 2018-01-11 Sangamo Therapeutics, Inc. Targeted treatment of leber congenital amourosis
CA3030156A1 (en) 2016-07-07 2018-01-11 Iovance Biotherapeutics, Inc. Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof
WO2018013558A1 (en) 2016-07-12 2018-01-18 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
US10245064B2 (en) 2016-07-12 2019-04-02 Ethicon Llc Ultrasonic surgical instrument with piezoelectric central lumen transducer
US11134864B2 (en) 2016-07-13 2021-10-05 Alexei L. Vyssotski Tracking method and system for small animal research
AU2017295720B2 (en) 2016-07-13 2021-07-22 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
EP3484613B1 (en) 2016-07-14 2021-02-24 Puridify Ltd. Functionalised chromatography medium comprising polymer nanofibres and process of preparation thereof
WO2018014174A1 (en) 2016-07-19 2018-01-25 General Electric Company Ultrasonic separation of a production stream
EP3487982A1 (en) 2016-07-21 2019-05-29 Celyad Method and apparatus for automated independent parallel batch-processing of cells
CN109691230B (zh) * 2016-07-22 2021-09-03 路创技术有限责任公司 模块化照明面板
JP2019522008A (ja) 2016-07-25 2019-08-08 セルラー アプローチズ,インク. 治療方法で使用される自己由来および同種異系のマクロファージと単球
JP2019525759A (ja) 2016-07-25 2019-09-12 ブルーバード バイオ, インコーポレイテッド Bcl11aホーミングエンドヌクレアーゼバリアント、組成物、および使用方法
WO2018022930A1 (en) 2016-07-27 2018-02-01 The Board Of Trustees Of The Leland Stanford Junior University Immolative cell-penetrating complexes for nucleic acid delivery
CN109890619B (zh) 2016-07-27 2021-01-26 哈佛学院院长及董事 用于声泳打印的设备和方法
WO2018021920A1 (en) 2016-07-27 2018-02-01 The University Of Canterbury Maskless speech airflow measurement system
ES2908736T3 (es) 2016-07-28 2022-05-03 Charles Stark Draper Laboratory Inc Separación acústica para bioprocesamiento
WO2018023114A1 (en) 2016-07-29 2018-02-01 Ohio State Innovation Foundation Expression of pten-long with ocolytic viruses
CN109715789B (zh) 2016-08-01 2023-04-04 刘扶东 内部封定脂囊泡
EP3493907B1 (en) 2016-08-02 2023-10-04 IMEC vzw Method and arrangement for focusing objects in a flow
KR102561368B1 (ko) 2016-08-03 2023-08-01 론자 워커스빌 아이엔씨. 실질적으로 코아굴로겐이 없는 리물루스 아메보사이트 라이세이트를 이용한 내독소 검출방법
US10160061B2 (en) 2016-08-15 2018-12-25 The Aerospace Corporation Systems and methods for modifying acoustic waves based on selective heating
MY196321A (en) 2016-08-16 2023-03-24 Regeneron Pharma Methods for Quantitating Individual Antibodies From a Mixture
MA45996A (fr) 2016-08-16 2021-06-02 Bluebird Bio Inc Variants d'endonucléase de homing du récepteur alpha de l'il-10, compositions et méthodes d'utilisation associées
CA3034208A1 (en) 2016-08-16 2018-02-22 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
CN109642868B (zh) 2016-08-19 2022-03-15 国立大学法人香川大学 光学特性测定装置和光学特性测定方法
WO2018035423A1 (en) 2016-08-19 2018-02-22 Bluebird Bio, Inc. Genome editing enhancers
EP3500244A4 (en) 2016-08-22 2020-05-13 Codiak BioSciences, Inc. METHOD FOR SUPPRESSING THE DELIVERY OF EXOSOMES TO LIVER AND SPLEEN
CN109863238A (zh) 2016-08-23 2019-06-07 弗洛设计声能学公司 声学生物反应器方法
US10736649B2 (en) 2016-08-25 2020-08-11 Ethicon Llc Electrical and thermal connections for ultrasonic transducer
US10952759B2 (en) 2016-08-25 2021-03-23 Ethicon Llc Tissue loading of a surgical instrument
WO2018045284A1 (en) 2016-09-02 2018-03-08 The General Hospital Corporation Methods and systems for non-contact construction of an internal structure
EP4248979A3 (en) 2016-09-08 2023-12-20 2seventy bio, Inc. Pd-1 homing endonuclease variants, compositions, and methods of use
EP3512540A1 (en) 2016-09-14 2019-07-24 Université Catholique de Louvain Modified vsv-g and vaccines thereof
WO2018057825A1 (en) 2016-09-23 2018-03-29 The Curators Of The University Of Missouri Antigen-specific immune modulation
WO2018058275A1 (zh) 2016-09-27 2018-04-05 深圳智乐信息科技有限公司 一种使用移动终端的智能驾驶方法及系统
US10979012B2 (en) 2016-09-30 2021-04-13 Intel Corporation Single-flipped resonator devices with 2DEG bottom electrode
WO2018067614A1 (en) 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Fiber microfluidics
WO2018081476A2 (en) 2016-10-27 2018-05-03 Intima Bioscience, Inc. Viral methods of t cell therapy
EP3533012A4 (en) 2016-10-28 2020-04-22 Indiggo Associates, Inc. SYSTEM AND METHOD FOR CONVERTING A DIGITAL CALENDAR TO A STRATEGIC TOOL
GB201618508D0 (en) 2016-11-02 2016-12-14 Imp Innovations Ltd Implantable device
US10830738B2 (en) 2016-11-14 2020-11-10 University Of Alberta Ultrasensitive high Q-factor AT-cut-quartz crystal microbalance femtogram mass sensor
US20180136167A1 (en) 2016-11-16 2018-05-17 Battelle Energy Alliance, Llc Acoustic measurement infrastructure method and system for process monitoring, diagnostics, and prognostics
CN117720665A (zh) 2016-11-17 2024-03-19 2赛文缇生物公司 TGFβ信号转换器
FR3058644B1 (fr) 2016-11-17 2022-04-22 Commissariat Energie Atomique Procede et dispositif de concentration de particules par acoustophorese
GB201619559D0 (en) 2016-11-18 2017-01-04 Univ Oxford Innovation Ltd Acoustic excitation and detection of spin waves
WO2018098671A1 (en) 2016-11-30 2018-06-07 China Agricultural University A method for crispr library screening
WO2018102752A1 (en) 2016-12-02 2018-06-07 Cartesian Therapeutics, Inc. Cancer immuno therapy with highly enriched cd8+ chimeric antigen receptor t cells
JP6414994B2 (ja) 2016-12-06 2018-10-31 学校法人同志社 液晶可変焦点レンズおよび焦点距離制御方法
WO2018106163A1 (en) 2016-12-07 2018-06-14 Dirac Research Ab Audio precompensation filter optimized with respect to bright and dark zones
JP7483374B2 (ja) 2016-12-15 2024-05-15 ベックマン コールター, インコーポレイテッド 細胞洗浄装置及び方法
WO2018112335A1 (en) 2016-12-16 2018-06-21 Dolby Laboratories Licensing Corporation Audio speaker with full-range upward firing driver for reflected sound projection
US10212526B2 (en) * 2017-01-13 2019-02-19 Bose Corporation Acoustic pressure reducer and engineered leak
US9909313B1 (en) 2017-01-19 2018-03-06 Austin M. Grubbs Composite materials, methods of making composite materials, and enclosures constructed from composite materials
MX2019008844A (es) 2017-01-26 2019-09-10 Sangamo Therapeutics Inc Ingenieria de celulas b.
WO2018140845A2 (en) 2017-01-27 2018-08-02 Duke University Bi-specific antibodies to cd64 and a disease antigen
JP2020505074A (ja) 2017-01-30 2020-02-20 カー・ヴェー・エス ザート エス・エー ウント コー. カー・ゲー・アー・アーKWS SAAT SE & Co. KGaA ゲノム工学のためのエンドヌクレアーゼに対する修復鋳型の結合
TW201839136A (zh) 2017-02-06 2018-11-01 瑞士商諾華公司 治療血色素異常症之組合物及方法
US20180223256A1 (en) 2017-02-09 2018-08-09 University Of Rochester Modified t cells and their uses in treating cancer
CA2994643A1 (en) 2017-02-14 2018-08-14 Bart Lipkens Bioreactor using acoustic standing waves
MX2019009753A (es) 2017-02-16 2019-12-18 Firststring Res Inc Composicion y metodos para prevenir lesion por radiacion y promover la regeneracion de tejidos.
AU2018222735B2 (en) 2017-02-17 2023-04-27 George Todaro Use of TGF alpha for the treatment of diseases and disorders
GB201703116D0 (en) 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
WO2018160548A1 (en) 2017-02-28 2018-09-07 Cardiodx, Inc. Markers for coronary artery disease and uses thereof
WO2018161026A1 (en) 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il15 compositions and methods for immunotherapy
JP2020511528A (ja) 2017-03-03 2020-04-16 オブシディアン セラピューティクス, インコーポレイテッド 免疫療法のための組成物及び方法
WO2018161038A1 (en) 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il12 compositions and methods for immunotherapy
SG11201907922PA (en) 2017-03-03 2019-09-27 Obsidian Therapeutics Inc Cd19 compositions and methods for immunotherapy
AU2018226824A1 (en) 2017-03-03 2019-09-19 Seagen Inc. Glycan-interacting compounds and methods of use
US11229809B2 (en) 2017-03-03 2022-01-25 California Institute Of Technology Selective disruption of neoplastic cells via resonant harmonic excitation
US10415506B2 (en) 2017-03-07 2019-09-17 United Technologies Corporation Multi degree of freedom flutter damper
EP3372813B8 (en) 2017-03-07 2021-04-07 Raytheon Technologies Corporation Multi degree of freedom flutter damper
EP3372814B1 (en) 2017-03-07 2022-05-04 Raytheon Technologies Corporation Asymmetric multi degree of freedom flutter damper
US10428765B2 (en) 2017-03-07 2019-10-01 United Technologies Corporation Asymmetric multi degree of freedom flutter damper
CN106932370B (zh) 2017-03-07 2019-08-13 中国农业科学院油料作物研究所 同步检测五种真菌毒素的层析时间分辨荧光试剂盒及应用
US11643342B2 (en) 2017-03-09 2023-05-09 B.G. Negev Technologies & Applications Ltd., At Ben-Gurion University Process and apparatus for purifying liquid
FR3064311B1 (fr) * 2017-03-22 2019-04-12 IFP Energies Nouvelles Procede de commande d'un systeme houlomoteur au moyen d'une loi de commande proportionnelle integrale
MX2019011775A (es) 2017-03-31 2020-02-05 Quest Diagnostics Invest Llc Metodos para la cuantificacion de insulina y peptido c.
WO2018202691A1 (en) 2017-05-02 2018-11-08 Linnaeus University Method for performing a bioleaching process of chalcopyrite
US11358140B2 (en) 2017-05-16 2022-06-14 Autonomous Medical Devices Inc. Apparatus for automatic sampling of biological species employing an amplification with a magnetic nanoparticle and propulsion method
US20180334697A1 (en) 2017-05-16 2018-11-22 Sensor Kinesis Corporation Method for isothermal dna detection using a modified crispr/cas system and the apparatus for detection by surface acoustic waves for gene editing
GB2588249B (en) 2017-06-12 2023-01-04 Sinai Health Sys Allograft tolerance without the need for systemic immune suppression
MX2019014960A (es) 2017-06-12 2020-08-06 Obsidian Therapeutics Inc Composiciones de fosfodiesterasa de tipo 5 (pde5) y métodos de inmunoterapia.
UY37758A (es) 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
WO2018232045A1 (en) 2017-06-13 2018-12-20 Flodesign Sonics, Inc. Driver and control for variable impedance load
US10987462B2 (en) 2017-06-14 2021-04-27 The Charles Stark Draper Laboratory, Inc. Acoustophoresis device having improved dimensions
US20200131498A1 (en) 2017-06-14 2020-04-30 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase
WO2018236708A1 (en) 2017-06-19 2018-12-27 Massachusetts Institute Of Technology SYSTEMS AND METHODS FOR MEASURING PARTICLE PROPERTIES
GB201709838D0 (en) 2017-06-20 2017-08-02 Univ Oslo Hf Method of modulating immune cells
WO2018235228A1 (ja) 2017-06-22 2018-12-27 株式会社島津製作所 抗原または抗抗体が結合したモノクローナル抗体の定量方法
US10781435B2 (en) 2017-06-22 2020-09-22 Catalyst Biosciences, Inc. Modified membrane type serine protease 1 (MTSP-1) polypeptides and methods of use
WO2018237239A1 (en) 2017-06-23 2018-12-27 Texas Tech University System METHOD AND DEVICE FOR HIGH-PERFORMANCE, LABEL-FREE HOLOGRAPHIC SCREENING AND TUMOR CELL ENUMERATION IN BLOOD
CN107071684B (zh) * 2017-06-23 2023-03-17 深圳精拓创新科技有限公司 扬声器t/s参数测试方法和测试装置
US20210355448A1 (en) 2017-06-26 2021-11-18 City Of Hope Methods of islet cell culture
TWI704923B (zh) 2017-06-26 2020-09-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 包含胞外囊泡之製劑、用以製備該製劑之方法及其用途
WO2019005866A1 (en) 2017-06-26 2019-01-03 The Broad Institute, Inc. NEW TYPE VI CRISPR ORTHOLOGISTS AND ASSOCIATED SYSTEMS
US10535425B2 (en) 2017-06-28 2020-01-14 Perceptimed, Inc. Inventory management
EP3421975A1 (en) 2017-06-30 2019-01-02 Centre National De La Recherche Scientifique Methods and device for manipulating objects
WO2019006418A2 (en) 2017-06-30 2019-01-03 Intima Bioscience, Inc. ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
US20220233588A1 (en) 2017-06-30 2022-07-28 Cellectis Cellular immunotherapy for repetitive administration
WO2019005155A1 (en) 2017-06-30 2019-01-03 Hewlett-Packard Development Company, L.P. IMAGING DEVICE COMPRISING AN AUDIO PART
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
WO2019010422A1 (en) 2017-07-07 2019-01-10 The Broad Institute, Inc. ANTIVIRAL THERAPY BASED ON THE CRISPR SYSTEM
EP3425386B1 (en) 2017-07-07 2022-04-13 Université de Strasbourg Online apparatus for in-depth characterization of antibody drug conjugates
WO2019018423A1 (en) 2017-07-17 2019-01-24 The Broad Institute, Inc. NEW TYPE VI CRISPR ORTHOLOGISTS AND ASSOCIATED SYSTEMS
BR112020001132A2 (pt) 2017-07-18 2020-07-21 Calimmune, Inc. interruptor modulável para seleção de células doadoras modificadas
US20200164060A1 (en) 2017-07-21 2020-05-28 Fred Hutchinson Cancer Research Center Herpes simplex virus vaccine epitopes specifically recognized by tissue resident memory t cells
US20210123038A1 (en) 2017-07-26 2021-04-29 Flodesign Sonics, Inc. Acoustic Transducer Automated Start and Run
EP3658125A4 (en) 2017-07-28 2021-04-28 National University of Singapore BIOMOLECULAR COMPOSITES INCLUDING MODIFIED CELL PHANTOMS
WO2019025984A1 (en) 2017-07-31 2019-02-07 Reflection Biotechnologies Limited CELLULAR MODELS AND THERAPIES FOR OCULAR DISEASES
CN111182951A (zh) 2017-08-01 2020-05-19 指南针制药有限责任公司 过滤和层析荚以及使用其的方法
US11266984B2 (en) 2017-08-03 2022-03-08 The Board Of Trustees Of The Leland Stanford Junior University Massive microfluidics for multiplexed counting
EP3437740A1 (en) 2017-08-04 2019-02-06 Nokia Technologies Oy Apparatus and method for positioning particles inside a channel
EP3665271A4 (en) 2017-08-08 2021-04-28 Sangamo Therapeutics, Inc. CELL TARGETING MEDIA BY A CHEMICAL ANTIGEN RECEPTOR
WO2019036382A1 (en) 2017-08-15 2019-02-21 Progenity Inc. INFLAMMATORY DISEASE TREATMENT INVOLVING AN INGREDIENT DEVICE FOR RELEASING AN IMMUNOMODULATOR
US10969324B2 (en) 2017-08-16 2021-04-06 Washington University Synthesis, post-modification and separation of biologics using acoustically confined substrates
EP3675835A4 (en) 2017-08-28 2021-06-09 Matthias Wagner MICROFLUIDIC LASER ACTIVATED INTRACELLULAR DELIVERY SYSTEMS AND METHODS
US11085902B2 (en) 2017-08-29 2021-08-10 Massachusetts Institute Of Technology Optical breakdown acoustic transducer
WO2019041344A1 (en) 2017-09-04 2019-03-07 Hebei University Of Science And Technology METHODS AND COMPOSITIONS FOR THE TRANSFECTION OF SINGLE STRANDED DNA
CA3074872A1 (en) 2017-09-07 2019-03-14 The Board Of Trustees Of The Leland Stanford Junior University Nuclease systems for genetic engineering
US12016314B2 (en) 2017-09-08 2024-06-25 Ohio State Innovation Foundation MicroRNA inhibitor therapy in systemic lupus erythematosus
WO2019051106A1 (en) 2017-09-08 2019-03-14 The Charles Stark Draper Laboratory Inc. DETECTION AND IDENTIFICATION OF BACTERIA AND DETERMINATION OF ANTIBIOTIC SENSITIVITY USING BACTERIOPHAGES AND MOLECULES REPORTERS
JP7274228B2 (ja) 2017-09-08 2023-05-16 ネオペプ ファーマ ゲーエムベーハー ウント コンパニー カーゲー 病気の治療のためのポリペプチド
EP3679143A1 (en) 2017-09-08 2020-07-15 Life Technologies Corporation Methods for improved homologous recombination and compositions thereof
EP3678710A4 (en) 2017-09-08 2021-06-09 Generation Bio Co. MODIFIED CLOSED-END DNA (CEDNA)
WO2019051316A1 (en) 2017-09-08 2019-03-14 Life Technologies Corporation ENHANCED APPROVAL RECOMBINATION METHODS AND COMPOSITIONS THEREOF
WO2019055817A1 (en) 2017-09-14 2019-03-21 The Regents Of The University Of California EX VIVO CONSERVATION AND EXPANSION OF STEM CELLS
US20190076473A1 (en) 2017-09-14 2019-03-14 Cellular Approaches, Inc. Autologous and allogenic macrophages and monocytes for use in therapeutic methods
CN114533863A (zh) 2017-09-15 2022-05-27 凯德药业股份有限公司 用于进行具有监管链和身份链生物样品跟踪的患者特异性免疫疗法规程的方法和系统
CN111093715A (zh) 2017-09-18 2020-05-01 儿童医院医疗中心 强绝缘子和其在基因递送中的用途
DK3456821T4 (da) 2017-09-19 2024-04-15 Deutsches Krebsforsch Ikke-integrerende dna-vektorer til genetisk modifikation af celler
US20200230221A1 (en) 2017-09-19 2020-07-23 Massachusetts Institute Of Technology Compositions for chimeric antigen receptor t cell therapy and uses thereof
WO2019057774A1 (en) 2017-09-19 2019-03-28 Deutsches Krebsforschungszentrum NON-INTEGRATING DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS
IT201700105911A1 (it) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo ed apparato per la riduzione del volume di un campione
IT201700105948A1 (it) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per il recupero di particelle
WO2019060779A1 (en) 2017-09-22 2019-03-28 City Of Hope OLIGONUCLEOTIDES SPLICE INHIBITORS
US20200354452A1 (en) 2017-09-29 2020-11-12 City Of Hope Cars and bispecific antibodies for treatment of mantle cell lymphoma
MX2020003536A (es) 2017-10-03 2020-09-14 Juno Therapeutics Inc Moleculas de union especifica a virus de papiloma humano (hpv).
US11779654B2 (en) 2017-10-04 2023-10-10 2Seventy Bio, Inc. PCSK9 endonuclease variants, compositions, and methods of use
GB2567188A (en) 2017-10-05 2019-04-10 Ft Tech Uk Ltd Fluid flow measuring device and associated method
US11052801B2 (en) 2017-10-06 2021-07-06 Harman International Industries, Incorporated Vehicle headrest with speakers and control for adaptive spatial performance
WO2019075409A1 (en) 2017-10-12 2019-04-18 The Regents Of The University Of California ISOLATION AND IDENTIFICATION WITHOUT MICROFLUIDIC LABEL OF CELLS USING FLUORESCENCE LIFE IMAGING (FLIM)
KR20200064131A (ko) 2017-10-13 2020-06-05 베링거 인겔하임 인터내셔날 게엠베하 관류 배지
US20190111480A1 (en) 2017-10-17 2019-04-18 Desktop Metal, Inc. Binder jetting in additive manufacturing of inhomogeneous three-dimensional parts
US11618780B2 (en) 2017-10-20 2023-04-04 City Of Hope Composition and method for activating latent human immunodeficiency virus (HIV)
WO2019081521A1 (en) 2017-10-25 2019-05-02 Universite De Lille ACOUSTIC KNIVES
WO2019087009A1 (en) 2017-11-01 2019-05-09 Mahmoud Amouzadeh Tabrizi Nanomotors for reduction of nitroarenes
US11788057B2 (en) 2017-11-01 2023-10-17 Mcmaster University 3D label-free contactless formation of cellular structures and co-cultures through diamagnetophoresis
US10304490B2 (en) 2017-11-02 2019-05-28 AcoustiX VR Inc. Acoustic holographic recording and reproduction system using meta material layers
CA3079748A1 (en) 2017-11-09 2019-05-16 Sangamo Therapeutics, Inc. Genetic modification of cytokine inducible sh2-containing protein (cish) gene

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