JP6901404B2 - 空間的な収束、操作、およびパターニングのための定在波場の高調波変調用システムおよび方法 - Google Patents
空間的な収束、操作、およびパターニングのための定在波場の高調波変調用システムおよび方法 Download PDFInfo
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Description
この出願の発明に関連する先行技術文献情報としては、以下のものがある(国際出願日以降国際段階で引用された文献及び他国に国内移行した際に引用された文献を含む)。
(先行技術文献)
(特許文献)
(特許文献1) 米国特許出願公開第2014/0011240号明細書
(特許文献2) 米国特許第6,246,895号明細書
(特許文献3) 米国特許出願公開第2010/0139377号明細書
(特許文献4) 米国特許出願公開第2012/0141552号明細書
(特許文献5) 米国特許出願公開第2015/0165091号明細書
(特許文献6) 米国特許出願公開第2015/0210979号明細書
(非特許文献)
(非特許文献1) LEV OSTROVSKY, "Concentration of microparticles and bubbles in standing waves", Journal Acoustical Society of America, 138 (6), December 2015, pp 3607−3612
(非特許文献2) KELLEY A. GARVIN et al., "Controlling collagen fiber microstructure in three−dimensional hydrogels using ultrasound", Journal of Acoustical Society of America, Vol. 134, No. 2, Pt 2, August 2013, pp 1491−1502
(非特許文献3) TIMOTHY E. DOYLE et al., "High−frequency ultrasound for intraoperative margin assessments in breast conservation surgery: a feasibility study", BioMed Central, http://www.biomedcentraol.com/147−2407/11/444, 2011, 15 pages
(非特許文献4) TIMOTHY E. DOYLE et al., "Histology−based simulations for the ultrasonic detection of microscopic cancer in vivo", JASA Express Letters, Journal of Acoustical Society of America, Vol. 122, No. 6, December 2007, pp EL210−EL216
(非特許文献5) TIMOTHY E. DOYLE et al., "Modeling the Permittivity of Two−Phase Media Containing Monodisperse Spheres: Effects of Microstructure and Multiple Scattering", Utah State University DigialCommons@USU, The American Physical Society, August 7, 2007, pp 054203−1 − 054203−14
(非特許文献6) KAI FENG et al., "Numerical analysis of the transportation characteristics of a self−running sliding stage based on near−field acoustic levitation", Journal Acoustical Society of America, 138 (6), December 2015, pp 3723−3732
(非特許文献7) "CARRIE POPPY, Physicists Use Souond to Levitate Cells and Check for Cancer", Tech Times, http://www.techtimes.com/articles/104948/20151110/physicists−use−sound−levitate−cells−check−cancer.htm, November 10, 2015
(非特許文献8) "Sound Waves Levitate Cells (acoustic levitation) to Detect Stiffness Changes That Could Signal Disease", Innovation Toronto, http://www.innovationtoronto.com/2015/11/sound−waves−levitate−cells−acoustic−levitation−to−detect−stiffness−changes−that−could−signal−disease/, November 6, 2015
(非特許文献9) "Sound Waves Levitate Cells to Detect Stiffness Changes That Could Signal Disease", Wise, www.newswise.com/articles/sound−waves−levitate−cells−to−detect−stiffness−changes−that−could−signal−disease, November 4, 2015
(非特許文献10) "Sound Waves Levitate Cells to Detect Stiffness Changes That Could Signal Disease", Phys.Org, http://phys.org/print36586342.html, November 4, 2015
(非特許文献11) "Sound Waves Levitate Cells to Detect Stiffness Changes That Could Signal Disease", ScienceDaily, https://www.sciencedaily.com/releases/2015/11/151104151012.htm, November 4, 2015
(非特許文献12) KELLEY A. GARVIN et al., "Spatial patterning of endothelial cells and vascular network formation using ultrasound standing wave fields", Journal of Acoustical Society of America, Vol. 134, No. 2, Pt 2, August 2013, pp 1483−1490
(非特許文献13) ERNEST L. MADSEN et al., "Tissue mimicking materials for ultrsound phantoms", Medical Physics, Vol 5, No. 5, October 1978, pp 391−394
種々の実施形態は、音響、電磁、または光による浮揚のための安定性の高い節領域の生成と、生体細胞、コロイド、エアロゾル、および粉末を含む浮揚微小粒子状物質の操作とを含むが、これに限定されるものではない。一部の実施形態では、組織工学用の生物材料または製造用の非生物材料をパターン化するため複雑に構造化された節領域を生成する。前記提供した方法では、流体中のキャビテーション、ソノルミネッセンス、またはソノケミストリーを強化するため高度に局所化した高音圧の腹領域を生成することができる。前記方法では、場合により、生物材料または非生物材料において適切に画成されたチャネルまたはキャビティを生成するため高度に局所化した高音圧の腹領域を生成する。特定の実施形態において、前記方法では、新規性のある物理的、化学的、または生物学的工程を開始するため、高度に局所化した高電磁場強度の腹領域を生成する。
Claims (13)
- システムであって、
粒子状物質を有する一定体積の流体を閉じ込めるように構成された チャンバーと、
前記チャンバーの別々の部分に配置された複数の多周波音響波トランスデューサと、
前記複数の多周波音響波トランスデューサによって生成される個々の高調波の振幅を制御することによって、三次元(3D)波動場パターンを有する定在波を生成する制御モジュールであり、前記三次元波動場パターンは、粒子状物質を一つまたは複数の前記粒子状物質が蓄積する安定した節領域内部に閉じ込める仮想テンプレートとして機能するものであり、前記各領域は前記流体の体積内に沈下しており、かつ各領域は前記三次元波動場パターンに対応する形状を有するものである、前記制御モジュールと、
三次元波動場パターンに対応する個々の高調波の振幅を計算する解析モジュールと、
を有するシステム。 - 請求項1記載のシステムにおいて、前記チャンバーの別々の部分に配置された複数の多周波音響波トランスデューサが、前記チャンバーの形状内で複数の内向きの角度で配向され、内向きの角度が、三次元波動場パターン内に節領域を生じさせる干渉パターンを生成するように構成され、前記三次元波動場パターンが、立方体、円筒形、球形、円錐形、回転楕円体、円錐形、多面体、角柱形、菱面体、およびそれらの組み合わせから選択される形状を有するものであるシステム。
- 請求項1記載のシステムにおいて、複数の多周波音響波トランスデューサのうちの少なくとも一つは、電磁アンテナ、レーザー高調波周波数発生器、メーザー高調波周波数発生器、小型化した多成分高周波(RF)発生器、高調波周波数機能を有するマイクロ波アンテナ、音響メタマテリアルを有する音響フィルター、小型開口部から単一周波数の平面波を音響散乱させたより高次の非線形高調波生成および高調波生成のうちの少なくとも1つを伴う放射の誘導放出による音増幅(Sound Amplification by Stimulated Emission of Radiation:SASER)、および広帯域の電磁波源または光学源を伴う調整可能な狭帯域フィルターからの入力に基づく三次元波動場パターンを有する定在波を生成するものであるシステム。
- 請求項3記載のシステムにおいて、前記複数の多周波音響波トランスデューサの少なくとも一つは、互いに電気的に絶縁され、異なる厚さに基づいて要素を固有の調和周波数に調整するように構成された異なる厚さを有する積層圧電素子を有し、前記積層圧電素子は、電圧源により協動的に駆動されることで多周波数波場を生成するものであるシステム。
- 請求項3記載のシステムにおいて、前記複数の多周波音響波トランスデューサの少なくとも一つは、任意の波形発生器により駆動されて三次元波動場パターンを有する定在波を直接生成する広帯域音響トランスデューサを有するものであるシステム。
- 空間的な収束およびパターン化のために定在波場の高調波変調を使って細胞または組織
をモデル化する方法であって、
a.目標組織を選択する工程と、
b.目標組織の構造を解析する工程と、
c.目標組織の構造を模倣する三次元波動場パターンを有する定在波をモデル化する工程と、
d.三次元波動場パターンに従った形態へと組織化するのに適した生体細胞を選択する工程と、
e.生体細胞を含む一定量の液体を閉じ込めるように構成されたチャンバーと、
チャンバーの別々の部分に配置された複数の多周波音響波トランスデューサと、
粒子状物質を有する一定体積の流体を閉じ込めるように構成されたチャンバーと、
前記チャンバーの区切られた部分に配置された複数の多周波音響波トランスデューサと、
前記複数の多周波音響波トランスデューサによって生成される個々の高調波の振幅を制御することによって、三次元(3D)波動場パターンに従った定在波を生成する制御モジュールであり、前記三次元波動場パターンは、生体細胞を一つまたは複数の前記生体細胞を蓄積する安定した節領域内部に閉じ込める仮想テンプレートとして機能するものであり、前記各領域は前記流体の体積内に沈下しており、かつ各領域は前記三次元波動場パターンに対応する形状を有するものである、前記制御モジュールと、
三次元波動場パターン、材料構造、または材料形状に対応する個々の高調波の振幅を計算する解析モジュールと
を有するシステムを提供する工程と、
f.前記チャンバー内に閉じ込められた流体の体積内に分散した適切な成長媒体を提供する工程と、
g.前記選択された生体細胞を前記成長媒体に加える工程と、
h.目標組織の構造を模倣する三次元波動場パターンを有する定在波を生成する制御モジュールをコントロールする工程と、
i.生体細胞に十分な時間を与えて、前記三次元波動場パターンにより決定される形態へと組織化させる定在波の生成を維持する工程と
を有する方法。 - 請求項6記載の方法において、さらに、
複雑な組織を模倣する構造の形成用に異なる細胞種で前記全ての工程を反復する工程を有するものである方法。 - 請求項6記載の方法において、正方形、長方形、三角形、および菱面体対称性から選択された少なくとも1つ以上の周期的な対称性のある三次元構造用の仮想テンプレートを生成するため、複数の多周波音響波トランスデューサが互いに90°および120°のうちの少なくとも1つの向きに配置されるものである方法。
- 請求項6記載の方法において、
複数の多周波音響波トランスデューサが、互いに対して内向きの角度で配向され、組織微細構造に類似した非周期およびランダム細胞構造、無秩序な構造または準結晶性構造から選択された少なくとも一つ以上の構造を生成するために108°、128.57°、135°から選択された内向きの角度に向けられたものである方法。 - 請求項6記載の方法であって、
さらに、三次元波動場パターン内に前記1つまたは複数の節領域を生成する干渉パターンを生成するように構成された複数の内向き角度で複数の多周波音響波トランスデューサを配向し、円柱形、円錐形、立方体、球形、回転楕円体、菱面体、多面体、および角柱形から選択された前記三次元波動場パターンの形状を有するものである方法。 - 請求項6記載の方法であって、
さらに、生体細胞が流れる仮想チャンバーに生体細胞を閉じ込めるための力場として、定在三次元波動場パターンを生成することを有するものである方法。 - 請求項6記載の方法であって、
さらに、三次元フーリエ解析、組織サンプルの連続スライスをミクロトームおよびイメージングから選択されたプロセスによって取得された前記目標組織の三次元微細構造、および三次元顕微鏡コンピュータ断層撮影法(マイクロCT)により行なわれるものである方法。 - 請求項7記載の方法において、さらに、
振幅スパイクを有する定在波を生成する工程を有し、
連続的な流路と空洞を持つ組織構造を形成可能な腹領域と、
通常の細胞クラスターおよびシートから選択されたうちの少なくとも一つ以上の組織構造を形成できる節領域とに対応するものである方法。
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