MX2019014960A - Composiciones de fosfodiesterasa de tipo 5 (pde5) y métodos de inmunoterapia. - Google Patents
Composiciones de fosfodiesterasa de tipo 5 (pde5) y métodos de inmunoterapia.Info
- Publication number
- MX2019014960A MX2019014960A MX2019014960A MX2019014960A MX2019014960A MX 2019014960 A MX2019014960 A MX 2019014960A MX 2019014960 A MX2019014960 A MX 2019014960A MX 2019014960 A MX2019014960 A MX 2019014960A MX 2019014960 A MX2019014960 A MX 2019014960A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- pde5
- immunotherapy
- proteins
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 101150098694 PDE5A gene Proteins 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04035—3',5'-Cyclic-GMP phosphodiesterase (3.1.4.35)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención hace referencia a composiciones y métodos para expresión controlada y regulada de proteínas. También se proporcionan métodos para inducir respuestas inmunitarias contra el cáncer en un sujeto.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762518078P | 2017-06-12 | 2017-06-12 | |
US201762523850P | 2017-06-23 | 2017-06-23 | |
US201762523862P | 2017-06-23 | 2017-06-23 | |
US201762555313P | 2017-09-07 | 2017-09-07 | |
PCT/US2018/037005 WO2018231759A1 (en) | 2017-06-12 | 2018-06-12 | Pde5 compositions and methods for immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019014960A true MX2019014960A (es) | 2020-08-06 |
Family
ID=64660633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019014960A MX2019014960A (es) | 2017-06-12 | 2018-06-12 | Composiciones de fosfodiesterasa de tipo 5 (pde5) y métodos de inmunoterapia. |
Country Status (9)
Country | Link |
---|---|
US (2) | US11241485B2 (es) |
EP (1) | EP3638289A4 (es) |
JP (2) | JP7362596B2 (es) |
CN (1) | CN111107866A (es) |
CA (1) | CA3067211A1 (es) |
MA (1) | MA49403A (es) |
MX (1) | MX2019014960A (es) |
SG (1) | SG11201912010XA (es) |
WO (1) | WO2018231759A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
EP3092049A1 (en) | 2014-01-08 | 2016-11-16 | Flodesign Sonics Inc. | Acoustophoresis device with dual acoustophoretic chamber |
WO2016100232A1 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
EP3589646A4 (en) * | 2017-03-03 | 2021-01-20 | Obsidian Therapeutics, Inc. | CD19 COMPOSITIONS AND PROCEDURES FOR IMMUNOTHERAPY |
EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
WO2018213882A1 (en) * | 2017-05-23 | 2018-11-29 | Biovite Australia Pty Ltd | Extracts from arthrospira and uses thereof |
BR112019024127A2 (pt) | 2017-05-24 | 2020-06-23 | Pandion Therapeutics, Inc. | Imunotolerância alvejada |
WO2018231759A1 (en) | 2017-06-12 | 2018-12-20 | Obsidian Therapeutics, Inc. | Pde5 compositions and methods for immunotherapy |
US11891634B2 (en) * | 2017-06-23 | 2024-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | PDE5A destabilizing domains |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
WO2019118921A1 (en) | 2017-12-14 | 2019-06-20 | Flodesign Sonics, Inc. | Acoustic transducer drive and controller |
WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
EP3894011A1 (en) * | 2018-12-11 | 2021-10-20 | Obsidian Therapeutics, Inc. | Membrane bound il12 compositions and methods for tunable regulation |
JP2022524509A (ja) * | 2019-03-08 | 2022-05-06 | オブシディアン セラピューティクス, インコーポレイテッド | Cd40lの組成と調整可能な制御のための方法 |
US20220195007A1 (en) * | 2019-04-12 | 2022-06-23 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors with cd20 safety switch |
US20220235143A1 (en) * | 2019-05-08 | 2022-07-28 | Memorial Sloan Kettering Cancer Center | Humanized antibodies to mucin-16 and methods of use thereof |
BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
EP3976659A4 (en) * | 2019-05-24 | 2023-02-22 | Memorial Sloan Kettering Cancer Center | ANTI-GLYPICAN-3 ANTIBODIES AND USES THEREOF |
WO2021034952A1 (en) * | 2019-08-19 | 2021-02-25 | Elpis Biopharmaceuticals | Anti-cd19 antibodies and uses thereof |
JP2022547154A (ja) * | 2019-09-10 | 2022-11-10 | オブシディアン セラピューティクス, インコーポレイテッド | 調節可能な制御のためのca2-il15融合タンパク質 |
US20240082403A1 (en) * | 2019-10-11 | 2024-03-14 | The Regents Of The University Of California | Chimeric Antigen Receptors against Human Cytomegalovirus |
EP4041769A1 (en) * | 2019-12-12 | 2022-08-17 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Antibody-drug conjugates specific for cd276 and uses thereof |
CN114929277A (zh) * | 2019-12-16 | 2022-08-19 | 2赛文缇生物公司 | 抗bcma car抗体、缀合物及使用方法 |
EP4077395A1 (en) * | 2019-12-20 | 2022-10-26 | Poseida Therapeutics, Inc. | Anti-muc1 compositions and methods of use |
KR20220139319A (ko) | 2020-01-08 | 2022-10-14 | 옵시디안 테라퓨틱스, 인크. | 조정 가능한 전사의 조절을 위한 조성물 및 방법 |
US11179473B2 (en) | 2020-02-21 | 2021-11-23 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
EP4107187A4 (en) | 2020-02-21 | 2024-07-03 | Pandion Operations Inc | TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR |
WO2021175250A1 (en) * | 2020-03-03 | 2021-09-10 | Aptorum Therapeutics Limited | Compounds and methods for treating diseases and/or conditions caused by coronavirus |
EP4127208A4 (en) * | 2020-04-03 | 2024-06-05 | University of Cincinnati | SECRETED PHOSPHORYLATED HEAT SHOCK PROTEIN 70 AS A BIOMARKER FOR THE TREATMENT AND DIAGNOSIS OF CANCER |
WO2021216686A1 (en) * | 2020-04-21 | 2021-10-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Treating and curing covid-19 infection utilizing a laser |
KR20230024984A (ko) * | 2020-06-12 | 2023-02-21 | 엔카르타, 인크. | Cd70-지시 암 면역요법용 유전적으로 변형된 자연 살해 세포 |
WO2021262773A1 (en) | 2020-06-22 | 2021-12-30 | Obsidian Therapeutics, Inc. | Compositions and methods for tunable regulation of cas nucleases |
WO2022006588A1 (en) * | 2020-06-29 | 2022-01-06 | Trustees Of Tufts College | Il-38 and analogues thereof for treatment of neuro-inflammatory and neurodegenerative diseases |
US11508453B2 (en) * | 2020-08-18 | 2022-11-22 | Micron Technology, Inc. | Encoding test data of microelectronic devices, and related methods, devices, and systems |
GB202013477D0 (en) * | 2020-08-27 | 2020-10-14 | Quell Therapeutics Ltd | Nucleic acid constructs for expressing polypeptides in cells |
CN114516914B (zh) * | 2020-11-19 | 2023-04-28 | 东莞市朋志生物科技有限公司 | 抗n末端脑钠肽前体的抗体和检测n末端脑钠肽前体的试剂和试剂盒 |
EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
WO2022159939A1 (en) | 2021-01-19 | 2022-07-28 | Obsidian Therapeutics, Inc. | Tumor-infiltrating lymphocytes with membrane bound interleukin 15 and uses thereof |
CN117751145A (zh) * | 2021-04-28 | 2024-03-22 | 礼进生物医药科技(上海)有限公司 | 包括抗b7h3结合分子的双特异性抗体 |
EP4341286A1 (en) * | 2021-05-19 | 2024-03-27 | Celledit LLC | Bi-specific chimeric antigen receptors and genetically engineered immune cells expressing such |
JPWO2023286841A1 (es) * | 2021-07-16 | 2023-01-19 | ||
CN113564184B (zh) * | 2021-07-16 | 2023-04-18 | 昆明理工大学 | 一种天麻谷氨酰胺合成酶基因及其应用 |
WO2023009700A2 (en) | 2021-07-29 | 2023-02-02 | Takeda Pharmaceutical Company Limited | Car-expressing immune cells that specifically target mesothelin and uses thereof |
CA3233380A1 (en) | 2021-10-18 | 2023-04-27 | Dhruv SETHI | Compositions and systems for regulation of function/abundance and delivery of polypeptide payloads |
WO2023141436A1 (en) | 2022-01-18 | 2023-07-27 | Obsidian Therapeutics, Inc. | Methods for identifying and using allogeneic tumor infiltrating lymphocytes to treat cancer |
CN114606323B (zh) * | 2022-04-24 | 2023-11-10 | 深圳大学 | 一种识别胃癌干细胞的标志物lgsn作为胃癌诊断和治疗靶标的应用 |
US20230348548A1 (en) * | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
EP4374872A1 (en) * | 2022-11-22 | 2024-05-29 | Koninklijke Philips N.V. | Pde enhanced car-t cells |
CN117482245A (zh) * | 2022-12-30 | 2024-02-02 | 英百瑞(杭州)生物医药有限公司 | 抗5t4抗体-自然杀伤细胞偶联物及其用途 |
WO2024165024A1 (zh) * | 2023-02-09 | 2024-08-15 | 星尘生物科技(上海)有限公司 | 一种嵌合抗原受体及其应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2346937A1 (en) * | 1998-10-15 | 2000-04-27 | Per O. G. Arkhammar | Specific therapeutic interventions obtained by interference with redistribution and/or targeting |
FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
AU2002357110A1 (en) | 2001-12-07 | 2003-07-09 | The Ohio State University Research Foundation | Apoptotic ebv-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder |
US20050048573A1 (en) | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
NZ551240A (en) | 2004-05-28 | 2009-08-28 | Nycomed Gmbh | Method for identifying PDE5-modulators |
WO2007142929A2 (en) | 2006-05-31 | 2007-12-13 | The University Of North Carolina At Chapel Hill | Novel pde4 inhibitors |
US8173792B2 (en) | 2007-02-09 | 2012-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells using synthetic small molecules |
US8530636B2 (en) | 2008-05-07 | 2013-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells in vivo using synthetic small molecules |
JP2012513464A (ja) | 2008-12-23 | 2012-06-14 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | ホスホジエステラーゼ阻害剤及びその使用 |
ES2962571T3 (es) | 2012-05-25 | 2024-03-19 | Cellectis | Métodos para modificar células T alogénicas y resistentes a la inmunosupresión para inmunoterapia |
US20140255361A1 (en) | 2013-03-07 | 2014-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Estrogen-receptor based ligand system for regulating protein stability |
UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
AU2015321603A1 (en) | 2014-09-22 | 2017-04-13 | Intrexon Corporation | Improved therapeutic control of heterodimeric and single chain forms of interleukin-12 |
US9766255B2 (en) * | 2015-01-12 | 2017-09-19 | President And Fellows Of Harvard College | Biosensors engineered from conditionally stable ligand-binding domains |
WO2016210293A1 (en) * | 2015-06-25 | 2016-12-29 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
CA2995036A1 (en) * | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation |
US11052111B2 (en) * | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
EP3443001A4 (en) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
WO2017210617A2 (en) | 2016-06-02 | 2017-12-07 | Porter, David, L. | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
WO2018161038A1 (en) | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il12 compositions and methods for immunotherapy |
WO2018161026A1 (en) | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
EP3589646A4 (en) | 2017-03-03 | 2021-01-20 | Obsidian Therapeutics, Inc. | CD19 COMPOSITIONS AND PROCEDURES FOR IMMUNOTHERAPY |
JP2020511528A (ja) | 2017-03-03 | 2020-04-16 | オブシディアン セラピューティクス, インコーポレイテッド | 免疫療法のための組成物及び方法 |
WO2018231759A1 (en) | 2017-06-12 | 2018-12-20 | Obsidian Therapeutics, Inc. | Pde5 compositions and methods for immunotherapy |
US11891634B2 (en) | 2017-06-23 | 2024-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | PDE5A destabilizing domains |
-
2018
- 2018-06-12 WO PCT/US2018/037005 patent/WO2018231759A1/en unknown
- 2018-06-12 MX MX2019014960A patent/MX2019014960A/es unknown
- 2018-06-12 MA MA049403A patent/MA49403A/fr unknown
- 2018-06-12 EP EP18817018.7A patent/EP3638289A4/en active Pending
- 2018-06-12 US US16/621,593 patent/US11241485B2/en active Active
- 2018-06-12 CA CA3067211A patent/CA3067211A1/en active Pending
- 2018-06-12 SG SG11201912010XA patent/SG11201912010XA/en unknown
- 2018-06-12 CN CN201880051747.6A patent/CN111107866A/zh active Pending
- 2018-06-12 JP JP2020517774A patent/JP7362596B2/ja active Active
-
2022
- 2022-02-01 US US17/649,592 patent/US11666642B2/en active Active
-
2023
- 2023-08-18 JP JP2023133318A patent/JP2023144094A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US11666642B2 (en) | 2023-06-06 |
JP7362596B2 (ja) | 2023-10-17 |
US11241485B2 (en) | 2022-02-08 |
US20200101142A1 (en) | 2020-04-02 |
EP3638289A4 (en) | 2021-03-24 |
JP2023144094A (ja) | 2023-10-06 |
SG11201912010XA (en) | 2020-01-30 |
WO2018231759A1 (en) | 2018-12-20 |
MA49403A (fr) | 2021-03-24 |
CN111107866A (zh) | 2020-05-05 |
US20230074330A1 (en) | 2023-03-09 |
CA3067211A1 (en) | 2018-12-20 |
EP3638289A1 (en) | 2020-04-22 |
JP2020525536A (ja) | 2020-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019014960A (es) | Composiciones de fosfodiesterasa de tipo 5 (pde5) y métodos de inmunoterapia. | |
CY1123163T1 (el) | Αντισωματα που δεσμευουν beta klotho επικρατεια 2 και μεθοδοι χρησης αυτων | |
PH12018500950A1 (en) | Subcutaneous formulations of anti-cd38 antibodies and their uses | |
IL296740A (en) | Compositions and methods for the induction of CD8-positive t-cells | |
MX2021013837A (es) | Enfoque de inmunoterapias de combinacion para el tratamiento del cancer. | |
PH12018500711A1 (en) | Anti-pd1 antibodies and methods of use | |
MX2022006513A (es) | Constructos de expresion y metodos para dise?ar geneticamente levadura metilotrofica. | |
MY193723A (en) | Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1 | |
EP4335874A3 (en) | Anti-hla-g antibodies and use thereof | |
TW201613966A (en) | SynTac polypeptides and uses thereof | |
PH12017501077A1 (en) | Compositions and methods for antibodies targeting bmp6 | |
MA40061A (fr) | Compositions immunogènes à base de listeria pour provoquer des réponses anti-tumorales | |
MX2018003183A (es) | Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas. | |
MA40527A (fr) | Protéines de liaison à l'antigène se liant à wisp5 | |
MY191539A (en) | Streptococcal vaccine | |
MX2018009794A (es) | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. | |
MX2017001038A (es) | Variantes de proteina de unión al factor h y metodos de uso de estas. | |
GB201718342D0 (en) | Allergenic protein formulations for immunotherapy | |
MY167350A (en) | Fat-and-oil composition and chocolate | |
MX2019007433A (es) | Metodos y formulaciones para reducir el tiempo de reconstitucion de los polipeptidos liofilizados. | |
NZ721832A (en) | Solid forms of tenofovir | |
MX2018011193A (es) | Proteinas derivadas de alfa-1-microglobulina novedosas y su uso. | |
IN2014CN00547A (es) | ||
EP3298035A4 (en) | Methods and compositions related to antigen presenting proteins | |
WO2018236876A3 (en) | NANOEMULSIONS AND METHODS OF USE THEREOF |