RU2011107877A - Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты - Google Patents
Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты Download PDFInfo
- Publication number
- RU2011107877A RU2011107877A RU2011107877/15A RU2011107877A RU2011107877A RU 2011107877 A RU2011107877 A RU 2011107877A RU 2011107877/15 A RU2011107877/15 A RU 2011107877/15A RU 2011107877 A RU2011107877 A RU 2011107877A RU 2011107877 A RU2011107877 A RU 2011107877A
- Authority
- RU
- Russia
- Prior art keywords
- component
- crosslinked
- nahc
- obtaining
- cross
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Inorganic Chemistry (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Способ получения композиции наполнителя мягких тканей, включающий следующие стадии: ! получение компонента ГК (гиалуроновой кислоты), перекрестно-сшитого с помощью по меньшей мере одного перекрестно-сшивающего агента, выбранного из группы, состоящей из 1,4-бутандиолдиглицидильного эфира (БДДЭ), 1,4-бис(2,3-эпоксипропокси)бутана, 1,4-бисглицидилоксибутана, 1,2-бис(2,3-эпоксипропокси)этилена, 1-(2,3-эпоксипропил)-2,3-эпоксициклогексана, 1,4-бутандиолдиглицидильного эфира или их комбинаций; ! доведение рН указанного компонента ГК до рН больше приблизительно 7,2; и ! добавление раствора, содержащего по меньшей мере один обезболивающий агент, к указанному компоненту ГК, имеющему указанный доведенный рН, с получением композиции наполнителя мягких тканей на основе ГК. !2. Способ по п.1, где указанный доведенный рН составляет больше приблизительно 7,5. !3. Способ по п.1, где указанный по меньшей мере один обезболивающий агент представляет собой лидокаин. ! 4. Способ по п.1, где на указанной стадии получения компонента ГК осуществляют стадии получения сухого не сшитого перекрестно вещества NаГК и гидратирования указанного сухого не сшитого перекрестно вещества NaГK в щелочном растворе с получением щелочного не сшитого перекрестно геля NаГК. ! 5. Способ по п.4, где указанный щелочной не сшитый перекрестно гель NаГК имеет рН больше чем приблизительно 8,0. ! 6. Способ по п.4, где указанный щелочной не сшитый перекрестно гель NаГК имеет рН больше чем приблизительно 10. ! 7. Способ по п.1, где компонент ГК содержит больше чем приблизительно 10% не сшитой перекрестно ГК. ! 8. Способ по п.1, где компонент ГК содержит по меньшей мере приблизительно 20% не сшитой п
Claims (11)
1. Способ получения композиции наполнителя мягких тканей, включающий следующие стадии:
получение компонента ГК (гиалуроновой кислоты), перекрестно-сшитого с помощью по меньшей мере одного перекрестно-сшивающего агента, выбранного из группы, состоящей из 1,4-бутандиолдиглицидильного эфира (БДДЭ), 1,4-бис(2,3-эпоксипропокси)бутана, 1,4-бисглицидилоксибутана, 1,2-бис(2,3-эпоксипропокси)этилена, 1-(2,3-эпоксипропил)-2,3-эпоксициклогексана, 1,4-бутандиолдиглицидильного эфира или их комбинаций;
доведение рН указанного компонента ГК до рН больше приблизительно 7,2; и
добавление раствора, содержащего по меньшей мере один обезболивающий агент, к указанному компоненту ГК, имеющему указанный доведенный рН, с получением композиции наполнителя мягких тканей на основе ГК.
2. Способ по п.1, где указанный доведенный рН составляет больше приблизительно 7,5.
3. Способ по п.1, где указанный по меньшей мере один обезболивающий агент представляет собой лидокаин.
4. Способ по п.1, где на указанной стадии получения компонента ГК осуществляют стадии получения сухого не сшитого перекрестно вещества NаГК и гидратирования указанного сухого не сшитого перекрестно вещества NaГK в щелочном растворе с получением щелочного не сшитого перекрестно геля NаГК.
5. Способ по п.4, где указанный щелочной не сшитый перекрестно гель NаГК имеет рН больше чем приблизительно 8,0.
6. Способ по п.4, где указанный щелочной не сшитый перекрестно гель NаГК имеет рН больше чем приблизительно 10.
7. Способ по п.1, где компонент ГК содержит больше чем приблизительно 10% не сшитой перекрестно ГК.
8. Способ по п.1, где компонент ГК содержит по меньшей мере приблизительно 20% не сшитой перекрестно ГК.
9. Способ по п.1, где компонент ГК имеет степень перекрестного сшивания меньше чем приблизительно 5%.
10. Способ по п.1, где компонент ГК содержит частицы перекрестно-сшитой ГК, имеющей средний размер частиц больше чем приблизительно 200 мкм.
11. Способ по п.1, где компонент ГК представляет собой некогезионную композицию.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8595608P | 2008-08-04 | 2008-08-04 | |
US61/085,956 | 2008-08-04 | ||
US8793408P | 2008-08-11 | 2008-08-11 | |
US61/087,934 | 2008-08-11 | ||
US9627808P | 2008-09-11 | 2008-09-11 | |
US61/096,278 | 2008-09-11 | ||
US12/393,768 US8450475B2 (en) | 2008-08-04 | 2009-02-26 | Hyaluronic acid-based gels including lidocaine |
US12/393,884 US8357795B2 (en) | 2008-08-04 | 2009-02-26 | Hyaluronic acid-based gels including lidocaine |
US12/393,884 | 2009-02-26 | ||
US12/393,768 | 2009-02-26 | ||
PCT/IB2009/005046 WO2010015900A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2011107877A true RU2011107877A (ru) | 2012-09-10 |
RU2496474C2 RU2496474C2 (ru) | 2013-10-27 |
Family
ID=41608613
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011107878/15A RU2496473C2 (ru) | 2008-08-04 | 2009-03-02 | Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты |
RU2011107877/15A RU2496474C2 (ru) | 2008-08-04 | 2009-03-02 | Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011107878/15A RU2496473C2 (ru) | 2008-08-04 | 2009-03-02 | Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты |
Country Status (20)
Country | Link |
---|---|
US (22) | US8450475B2 (ru) |
EP (6) | EP3205332A1 (ru) |
JP (5) | JP5670899B2 (ru) |
KR (2) | KR101672562B1 (ru) |
CN (3) | CN102170855B (ru) |
AU (2) | AU2009278883B2 (ru) |
BR (3) | BRPI0917573B1 (ru) |
CA (6) | CA3112106C (ru) |
CY (2) | CY1118281T1 (ru) |
DK (3) | DK2326302T3 (ru) |
ES (3) | ES2622708T3 (ru) |
HK (2) | HK1156883A1 (ru) |
HU (3) | HUE031483T2 (ru) |
MX (3) | MX2011001322A (ru) |
PL (3) | PL2674147T3 (ru) |
PT (2) | PT2326302T (ru) |
RU (2) | RU2496473C2 (ru) |
SG (2) | SG10201505441TA (ru) |
SI (2) | SI2323617T1 (ru) |
WO (2) | WO2010015901A1 (ru) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
US20080293637A1 (en) * | 2007-05-23 | 2008-11-27 | Allergan, Inc. | Cross-linked collagen and uses thereof |
US20110077737A1 (en) * | 2007-07-30 | 2011-03-31 | Allergan, Inc. | Tunably Crosslinked Polysaccharide Compositions |
US20120071437A1 (en) | 2007-07-30 | 2012-03-22 | Allergan, Inc. | Tunable crosslinked polysaccharide compositions |
US8318695B2 (en) * | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
BRPI0819075A2 (pt) | 2007-11-16 | 2014-10-07 | Vicept Therapeutics Inc | Método para tratar púrpura em um indivíduo e método para diminuir a púrpura em um indivíduo antes de um procedimento cirúrgico |
US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
US20090143348A1 (en) * | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
US8394784B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
US20130102563A1 (en) * | 2008-08-04 | 2013-04-25 | Allergan, Inc. | Dermal filler with lidocaine |
US8450475B2 (en) * | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
EP3184552B1 (en) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Threads of hyaluronic acid, methods of making thereof and uses thereof |
AU2009322463B2 (en) | 2008-12-02 | 2015-10-08 | Allergan, Inc. | Injection device |
IT1395392B1 (it) * | 2009-08-27 | 2012-09-14 | Fidia Farmaceutici | Geli viscoelastici come nuovi filler |
US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
US20110171286A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan, Inc. | Hyaluronic acid compositions for dermatological use |
US20110171311A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
US20110171310A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use |
AU2015234293B2 (en) * | 2010-01-13 | 2017-04-27 | Allergan Industrie Sas | Stable hydrogel compositions including additives |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
NZ602405A (en) | 2010-03-12 | 2014-12-24 | Allergan Ind Sas | A fluid composition comprising a hyaluronan polymer and mannitol for improving skin conditions |
AU2011229730B2 (en) | 2010-03-22 | 2016-01-07 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
WO2012008722A2 (ko) * | 2010-07-12 | 2012-01-19 | 신풍제약 주식회사 | 조직 증강용 충전 조성물 |
US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
PL3138586T3 (pl) * | 2010-11-08 | 2021-09-13 | Allergan Industrie, Sas | Wypełniacz tkanki miękkiej |
PT2637710T (pt) * | 2010-11-08 | 2017-07-12 | Allergan Ind Sas | Formulações à base de ácido hialurónico |
FR2968305B1 (fr) | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
EA201391014A1 (ru) * | 2011-01-06 | 2014-01-30 | С. Лоуэлл Парсонс | Способ производства композиции, содержащей местный анестетик, гепариноид и буфер |
EP2663342B1 (en) * | 2011-01-13 | 2020-03-25 | Allergan, Inc. | Stable hydrogel compositions including phenylephrine |
EP2484387A1 (en) * | 2011-02-03 | 2012-08-08 | Q-Med AB | Hyaluronic acid composition |
KR102073027B1 (ko) * | 2011-04-05 | 2020-02-04 | 삼성전자 주식회사 | 반송파 집적 기술을 사용하는 무선통신시스템에서 복수 개의 타임 정렬 타이머 운용 방법 및 장치 |
CA2827615A1 (en) | 2011-02-17 | 2012-08-23 | Dennis E. Van Epps | Compositions and improved soft tissue replacement methods |
EP2606828B1 (en) * | 2011-12-20 | 2018-04-11 | Angioclinic AG | Hyaluronic acid and its use for treating venous insufficiency and varicose veins |
US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
EP3536307B1 (en) | 2011-06-03 | 2021-10-20 | ALLERGAN Industrie, SAS | Dermal filler compositions including antioxidants |
US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
LT2742070T (lt) * | 2011-08-10 | 2021-10-25 | Glycores 2000 Srl | Degradacijai atsparus tinklinis mažos molekulinės masės hialuronatas |
DK2747747T3 (da) | 2011-08-25 | 2020-03-09 | Allergan Ind Sas | Dermale fyldstofsammensætninger inklusive antioxidanter |
US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
RU2626513C2 (ru) | 2011-09-14 | 2017-07-28 | Аллерган, Инк. | Композиции кожного наполнителя для лечения мелких морщин |
EP2581079B1 (en) * | 2011-10-11 | 2016-12-07 | BioPolymer GmbH & Co. KG | Combination of hyaluronic acid and prilocaine |
EP3243533B1 (en) * | 2011-10-11 | 2020-06-17 | Allergan Holdings France S.A.S. | Threads of cross-linked hyaluronic acid and methods of use thereof |
ES2824232T3 (es) | 2011-12-08 | 2021-05-11 | Allergan Ind Sas | Composiciones de relleno dérmico |
CN102552974A (zh) * | 2012-02-17 | 2012-07-11 | 上海白衣缘生物工程有限公司 | 皮肤注射填充用凝胶组合物及其制备 |
LT2861626T (lt) * | 2012-06-15 | 2019-01-25 | Merz Pharma Gmbh & Co. Kgaa | Paruošimo būdas kompozicijos hialurono rūgšties pagrindu |
ES2660023T3 (es) * | 2012-07-18 | 2018-03-20 | Allergan Industrie, Sas | Formulación de ácido hialurónico que contiene piruvato |
CH705713B1 (de) * | 2012-09-21 | 2013-05-15 | Labo Cosprophar Ag | Dermokosmetische Zusammensetzung zur topischen Anwendung. |
EP2903588B1 (en) | 2012-10-02 | 2020-02-19 | Allergan, Inc. | Dermal filler hydrogels with vitamin a/cyclodextrin inclusion complexes |
WO2014055895A1 (en) | 2012-10-05 | 2014-04-10 | Allergan, Inc. | Injectable device and method for sculpting, augmenting or correcting facial features such as the chin |
US20140124514A1 (en) * | 2012-11-08 | 2014-05-08 | Onpharma, Inc. | Method and apparatus for adding buffers and other substances to medical cartridges |
BR112015017040B1 (pt) | 2013-01-17 | 2020-11-03 | Jeffrey Hagel | uso de ácido hialurônico para aumentar volume muscular de músculo e alterar contorno de músculo em um ser humano |
CN105263503A (zh) * | 2013-01-28 | 2016-01-20 | 奥利金制药公司 | 含有类肝素、急效麻醉剂及缓冲液的稳定组合物 |
BR112015021933B1 (pt) | 2013-03-08 | 2020-12-08 | Ultradent Products, Inc | dispositivo de tratamento oral, dispositivo de clareamento dental e método de fabricar um dispositivo de tratamento oral |
FR3006689A1 (fr) * | 2013-06-11 | 2014-12-12 | Benedicte Vincente Tauzin | Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu |
CN104225677B (zh) * | 2013-06-13 | 2016-09-21 | 山东省生物药物研究院 | 交联透明质酸细胞支架材料及其制备方法和应用 |
BR112015031329A2 (pt) * | 2013-06-14 | 2017-07-25 | Galderma Sa | composições compreendendo ciclodextrina e ácido hialurônico reticulado |
KR20160029818A (ko) * | 2013-07-08 | 2016-03-15 | 덴카 주식회사 | 코어 쉘형 가교 히알루론산 겔 입자, 그의 제조 방법 및 의료용 재료 |
US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
CA2923742C (en) * | 2013-09-27 | 2021-02-16 | Anteis S.A. | Method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine added in powder form, and an alkaline agent, sterilized with heat |
EP3052529B1 (en) | 2013-09-30 | 2017-10-04 | Galderma S.A. | Single-step functionalization and cross-linking of hyaluronic acid |
US10913853B2 (en) | 2013-10-11 | 2021-02-09 | Ultradent Products, Inc. | Wax-based compositions, articles made therefrom, and methods of manufacture and use |
KR102133526B1 (ko) * | 2013-10-31 | 2020-07-13 | 삼성전자주식회사 | USB 어플리케이션 데이터의 QoS를 고려한 무선 전송 지원 기법 |
US20150141910A1 (en) * | 2013-11-14 | 2015-05-21 | University Medical Pharmaceuticals Corporation | Microneedles for therapeutic agent delivery with improved mechanical properties |
FR3015290B1 (fr) * | 2013-12-23 | 2017-01-13 | Lab Vivacy | Compositions d'acide hyaluronique compreant de la mepivacaine |
WO2015112907A1 (en) * | 2014-01-27 | 2015-07-30 | Allergan Holdings France S.A.S. | Spherical forms of cross-linked hyaluronic acid and methods of use thereof |
AR099900A1 (es) | 2014-04-01 | 2016-08-24 | Merz Pharma Gmbh & Co Kgaa | Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso |
WO2015149177A1 (en) | 2014-04-01 | 2015-10-08 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
EP3126008B1 (en) * | 2014-04-02 | 2020-08-05 | Merz Pharma GmbH & Co. KGaA | In vivo degradation of polysaccharide-containing fillers |
WO2015164533A1 (en) * | 2014-04-22 | 2015-10-29 | Allergan, Inc. | Dry dermal filler compositions and methods of reconstitution |
EP3200838B1 (en) | 2014-09-30 | 2019-09-18 | Allergan Industrie, SAS | Stable hydrogel compositions including additives |
US20180265652A1 (en) * | 2014-10-08 | 2018-09-20 | Therakine Biodelivery Gmbh | Cross-linked biopolymer macroscopic systems and method of making same |
WO2016057607A1 (en) * | 2014-10-08 | 2016-04-14 | Therakine | Micronized hydrophilic cross-linked biopolymer systems and method of making same |
TWI716365B (zh) * | 2014-11-13 | 2021-01-21 | 德商梅茲製藥有限兩合公司 | 注射型真皮填充劑組合物及其套組、製備方法、與使用 |
JP6946187B2 (ja) | 2014-12-02 | 2021-10-06 | エボルブド バイ ネイチャー, インコーポレイテッド | シルク性能衣服及び製品、並びにこれらを製造する方法 |
FR3029928B1 (fr) | 2014-12-15 | 2018-03-09 | Teoxane | Gel reticule |
WO2016115532A1 (en) * | 2015-01-16 | 2016-07-21 | Spineovations, Inc. | Method of treating spinal disk |
CN105878051B (zh) * | 2015-01-26 | 2019-02-26 | 华熙福瑞达生物医药有限公司 | 蜂巢状透明质酸及其制备方法 |
CN107427584A (zh) | 2015-01-28 | 2017-12-01 | 阿勒根公司 | 关节脂肪垫制剂及其使用方法 |
WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
WO2016129967A1 (ko) * | 2015-02-13 | 2016-08-18 | 주식회사 엔도더마 | 가교된 히알루론산 하이드로젤을 이용한 마이크로구조체 및 이의 제조방법 |
WO2016132167A1 (en) * | 2015-02-16 | 2016-08-25 | Allergan Industrie, Sas | Implants for sculpting, augmenting or correcting facial features such as the chin |
PL3256179T3 (pl) * | 2015-02-13 | 2020-05-18 | Allergan Industrie, Sas | Implanty do kształtowania, uwydatniania lub korygowania cech twarzy takich jak broda |
US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
FR3036035B1 (fr) | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
FR3037797B1 (fr) | 2015-06-24 | 2018-08-17 | Kylane Laboratoires Sa | Procede de preparation d'un hydrogel reticule injectable; hydrogel obtenu; utilisation de l'hydrogel obtenu |
WO2017001056A1 (en) * | 2015-06-30 | 2017-01-05 | Merz Pharma Gmbh & Co. Kgaa | Method for producing crosslinked hyaluronic acid |
ES2836473T3 (es) | 2015-06-30 | 2021-06-25 | Merz Pharma Gmbh & Co Kgaa | Método de preparación de una composición basada en ácido hialurónico |
CN108135975A (zh) | 2015-07-14 | 2018-06-08 | 丝绸医疗公司 | 丝性能服装和产品及其制备方法 |
EP3328351A1 (en) | 2015-07-27 | 2018-06-06 | Galderma S.A. | A process for efficient cross-linking of hyaluronic acid |
CN105107018B (zh) * | 2015-08-19 | 2018-08-24 | 李媚 | 一种无菌可注射材料的制备方法 |
CN105131348B (zh) * | 2015-08-19 | 2018-01-16 | 李媚 | 一种无菌可注射材料 |
KR101720426B1 (ko) | 2015-09-01 | 2017-04-14 | (주)시지바이오 | 히알루론산 조성물 및 그의 제조방법 |
EP3162813A1 (en) * | 2015-11-02 | 2017-05-03 | Merz Pharma GmbH & Co. KGaA | Process for depleting epoxide species in crosslinked poly-saccharide gel compositions and compositions obtained thereby |
BR112018009337A8 (pt) | 2015-11-10 | 2019-02-26 | E Perito Paul | sistema e método para o aumento não cirúrgico da circunferência peniana |
RU2697671C1 (ru) * | 2015-11-24 | 2019-08-16 | БиЭмАй КОРЕЯ КО., ЛТД | Композиция для инъекций гиалуроновой кислоты, содержащей производное гиалуроновой кислоты и ДНК фракцию, и ее применение |
FR3044557B1 (fr) | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
KR102139337B1 (ko) | 2016-03-17 | 2020-07-29 | 주식회사 엘지생활건강 | 미세바늘패치를 이용한 히알루론산 필러 |
TWI727014B (zh) * | 2016-03-24 | 2021-05-11 | 德商梅茲製藥有限兩合公司 | 修飾透明質酸與其製造方法及其用途 |
KR101660211B1 (ko) * | 2016-06-07 | 2016-09-26 | 동국제약 주식회사 | 단일상과 이성상의 특성을 동시에 갖는 히알루론산 가교체, 이의 제조 방법 및 이의 용도 |
EP3895742A1 (en) | 2016-10-13 | 2021-10-20 | Allergan, Inc. | Coacervate hyaluronan hydrogels for dermal filler applications |
FR3058064B1 (fr) | 2016-10-28 | 2020-08-07 | Lab Vivacy | Composition a base d'acide hyaluronique comprenant de la mepivacaine |
US11382853B2 (en) * | 2016-11-11 | 2022-07-12 | Anteis S.A. | Hyaluronic acid dermal fillers crosslinked with citric acid, method for making same and uses thereof |
KR101879065B1 (ko) * | 2016-12-12 | 2018-07-17 | 구태훈 | 구형 입자를 갖는 연조직용 필러 및, 그 제조방법 |
KR101922711B1 (ko) * | 2016-12-28 | 2018-11-27 | 주식회사 유영제약 | 가교된 히알루론산겔의 정제 방법 |
KR102363007B1 (ko) * | 2017-01-18 | 2022-02-14 | 구태훈 | 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법 |
CN110573190B (zh) * | 2017-02-28 | 2022-01-25 | Cg生物技术有限公司 | 皮肤注入用组合物 |
AU2018228301B2 (en) | 2017-02-28 | 2020-12-17 | Cg Bio Co., Ltd. | Composition For Dermal Injection |
BR112019017795B1 (pt) | 2017-02-28 | 2022-12-06 | Cg Bio Co., Ltd. | Composição para injeção dérmica |
AU2018240375C1 (en) | 2017-03-22 | 2024-02-01 | Ascendis Pharma A/S | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
KR101917026B1 (ko) | 2017-03-24 | 2019-01-24 | 박원진 | 피부 주름 개선 또는 예방용 화장료 조성물 |
EP3609483A4 (en) * | 2017-04-12 | 2021-01-20 | Urigen Pharmaceuticals, Inc. | ITEM OF MANUFACTURING CONSISTING OF LOCAL ANESTHETICS, BUFFER AND GLYCOSAMINOGLYCANE IN A SYRINGE OF IMPROVED STABILITY |
SG11201913229PA (en) * | 2017-06-26 | 2020-01-30 | Evolved By Nature Inc | Silk-hyaluronic acid based tissue fillers and methods of using the same |
US20230190997A1 (en) * | 2017-06-26 | 2023-06-22 | Evolved By Nature, Inc. | Silk-hyaluronic acid based tissue filers and methods of using the same |
CN111712514A (zh) | 2017-09-27 | 2020-09-25 | 自然进化公司 | 丝涂布织物和产品及其制备方法 |
ES2960617T3 (es) | 2017-10-19 | 2024-03-05 | Lifecell Corp | Productos de matriz de tejido acelular fluida y métodos de producción |
KR102091452B1 (ko) * | 2017-12-19 | 2020-03-20 | 대화제약 주식회사 | 국소 마취제 및 히알루론산 하이드로겔을 포함하는 사전충전형 주사기의 제조방법 |
CN111918639A (zh) * | 2017-12-29 | 2020-11-10 | 马特克斯拉比有限公司 | 使用特定交联剂制备具有透明质酸基的填充物的方法 |
PL3731808T3 (pl) * | 2017-12-29 | 2024-03-18 | Matex Lab S.P.A. | Sposób przygotowania wypełniacza na bazie kwasu hialuronowego obejmujący etap zobojętnienia |
US11534384B2 (en) * | 2017-12-29 | 2022-12-27 | Matex Lab S.P.A. | Method to prepare a filler with hyaluronic acid base comprising a neutralization step |
IT201800001890A1 (it) * | 2018-01-25 | 2019-07-25 | Fidia Farm Spa | Composizioni farmaceutiche per il trattamento del dolore postoperatorio |
JP2021522926A (ja) | 2018-05-09 | 2021-09-02 | ザ ジョンズ ホプキンス ユニバーシティ | 軟組織の補填及び再生の増強のためのナノファイバー−ハイドロゲル複合体 |
AU2019267711A1 (en) | 2018-05-09 | 2020-12-03 | The Johns Hopkins University | Nanofiber-hydrogel composites for cell and tissue delivery |
CN108653817B (zh) * | 2018-05-24 | 2021-02-02 | 上海其胜生物制剂有限公司 | 一种新型胶原刺激剂的制备方法 |
KR102392812B1 (ko) * | 2018-07-06 | 2022-04-29 | 주식회사 엘지화학 | 높은 점탄성 및 응집성을 동시에 갖는 히알루론산 필러 |
AU2019302833B2 (en) * | 2018-07-10 | 2022-09-22 | Lg Chem, Ltd. | Hyaluronic acid filler having high lift capacity and low injection force |
WO2020030629A1 (en) | 2018-08-07 | 2020-02-13 | Merz Pharma Gmbh & Co. Kgaa | Method for dynamic filtration of a cross-linked hydrogel |
KR20200046649A (ko) | 2018-10-25 | 2020-05-07 | (주)뉴크레이티브랩 | 혼합상 히알루론산 제조방법 |
CA3122116C (en) * | 2018-12-20 | 2023-07-18 | Lg Chem, Ltd. | Filler having excellent filler properties comprising hyaluronic acid hydrogel |
BR112021012059A2 (pt) * | 2018-12-21 | 2021-10-19 | Lg Chem, Ltd. | Preenchedor compreendendo ácido hialurônico hidrogel com excelentes propriedades de preenchimento |
EP3946246A4 (en) * | 2019-03-24 | 2023-06-21 | Allergan Pharmaceuticals International Limited | INJECTABLE HOMOGENEOUS JELLS WITH SEVERAL FORMS OF HYALURONIC ACID AND PROCESS FOR THEIR PREPARATION |
US20220202793A1 (en) * | 2019-05-17 | 2022-06-30 | The Governing Council Of The University Of Toronto | Sustained release local anesthetic hydrogel composition |
WO2021132969A1 (ko) * | 2019-12-24 | 2021-07-01 | 주식회사 엘지화학 | 마취제, 완충 용액 및 히알루론산 하이드로겔을 포함하는 주사용 조성물 및 이의 제조방법 |
US11058640B1 (en) | 2020-04-07 | 2021-07-13 | Amc Group, Llc | Hyaluronate compositions and soft tissue fillers |
FR3109153B1 (fr) * | 2020-04-10 | 2022-07-15 | Teoxane SA | Compositions à base d’au moins deux glycosaminoglycanes |
US20230172968A1 (en) * | 2020-04-17 | 2023-06-08 | Prohibix Llc | Controlled release hyaluronic acid compositions |
KR102417671B1 (ko) * | 2020-04-28 | 2022-07-06 | 충남대학교산학협력단 | 자가가교 시스템을 가지는 히알루론산 기반 연조직 충전 조성물 및 이의 제조방법 |
KR102425496B1 (ko) | 2020-05-08 | 2022-07-26 | 주식회사 종근당 | 고탄성, 고점도 및 고유효 가교율을 갖는 히알루론산 가교체, 및 이의 제조방법 |
FR3111903B1 (fr) | 2020-06-24 | 2022-12-02 | Lab Vivacy | Procede d’incorporation de composes organiques en solution au sein d’un hydrogel |
CN111643730A (zh) * | 2020-07-14 | 2020-09-11 | 华熙生物科技股份有限公司 | 注射用交联透明质酸凝胶的制备方法及应用 |
WO2023080886A1 (en) * | 2020-09-29 | 2023-05-11 | Ziropa, Inc. | Compositions and methods for pain relief and numbing |
TR202101065A1 (tr) * | 2021-01-25 | 2022-08-22 | Hacettepe Ueniversitesi | Hyaluroni̇k asi̇t jel i̇çeren bi̇r doku dolgu malzemesi̇ ve üreti̇m yöntemi̇ |
KR102581434B1 (ko) * | 2021-02-09 | 2023-09-22 | (주)제테마 | 히알루론산 필러 조성물의 제조에 사용되는 용액 및 이를 이용한 히알루론산 필러 조성물 |
CN113449476B (zh) * | 2021-07-08 | 2022-07-05 | 浙江大学 | 基于Stacking的脱丁烷塔中丁烷含量软测量方法 |
KR102348467B1 (ko) * | 2021-07-14 | 2022-01-07 | 주식회사 휴메딕스 | Dna 분획물을 포함하는 필러 제조방법 및 이로부터 제조된 필러 |
KR102640893B1 (ko) * | 2021-11-12 | 2024-02-27 | 주식회사 유영제약 | 히알루론산 가교물을 포함하는 조성물의 제조방법 |
CN116212108B (zh) * | 2023-04-18 | 2023-10-20 | 杭州科腾生物制品有限公司 | 一种含利多卡因的双层交联凝胶及其制备方法和应用 |
Family Cites Families (270)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2128827A (en) | 1938-03-09 | 1938-08-30 | Frank B Killian | Method and apparatus for manufacturing thin rubber articles |
CA807629A (en) | 1966-06-30 | 1969-03-04 | Eigen Edward | Lotion and detergent compositions |
JPS4838158B1 (ru) | 1970-10-05 | 1973-11-15 | ||
CA949965A (en) | 1971-12-03 | 1974-06-25 | Robert H. Marchessault | Method of preparing cross-linked starch and starch derivatives |
US3769009A (en) * | 1971-12-29 | 1973-10-30 | Xerox Corp | Inking system for liquid particle migration on automatic machines |
US3949073A (en) | 1974-11-18 | 1976-04-06 | The Board Of Trustees Of Leland Stanford Junior University | Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution |
US4060081A (en) | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
US4233360A (en) | 1975-10-22 | 1980-11-11 | Collagen Corporation | Non-antigenic collagen and articles of manufacture |
CA1073360A (en) | 1975-10-22 | 1980-03-11 | John R. Daniels | Non-antigenic collagen and articles of manufacture |
JPS581933Y2 (ja) | 1979-04-23 | 1983-01-13 | 株式会社日本製鋼所 | ケ−ブルのクランプ装置 |
JPS55153711A (en) | 1979-05-19 | 1980-11-29 | Pola Chem Ind Inc | Cosmetic lotion |
US4279812A (en) | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
JPS6052129B2 (ja) | 1979-10-04 | 1985-11-18 | 呉羽化学工業株式会社 | 医療用コラ−ゲン繊維の製造法 |
US4424208A (en) | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
US4582640A (en) | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
US4501306A (en) | 1982-11-09 | 1985-02-26 | Collagen Corporation | Automatic syringe filling system |
SE442820B (sv) | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
SE456346B (sv) | 1984-07-23 | 1988-09-26 | Pharmacia Ab | Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning |
US4582865A (en) | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4605691A (en) | 1984-12-06 | 1986-08-12 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
SE8501022L (sv) | 1985-03-01 | 1986-09-02 | Pharmacia Ab | Format alster och forfarande for dess framstellning |
US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
US4642117A (en) | 1985-03-22 | 1987-02-10 | Collagen Corporation | Mechanically sheared collagen implant material and method |
SE452469B (sv) | 1986-06-18 | 1987-11-30 | Pharmacia Ab | Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma |
US4803075A (en) | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
FR2608456B1 (fr) | 1986-12-18 | 1993-06-18 | Mero Rousselot Satia | Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention |
US5385938B1 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
US5091171B2 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
US5079236A (en) | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
FR2623167B2 (fr) | 1987-08-14 | 1992-08-07 | Genus Int | Perfectionnement aux articles munis d'articulations elastiques se rigidifiant lors de leur mise en tension |
US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5643464A (en) | 1988-11-21 | 1997-07-01 | Collagen Corporation | Process for preparing a sterile, dry crosslinking agent |
US5614587A (en) | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
US5565519A (en) | 1988-11-21 | 1996-10-15 | Collagen Corporation | Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications |
SE462587B (sv) | 1988-11-30 | 1990-07-23 | Wiklund Henry & Co | Anordning vid maerkning av arbetsstycken med skrift- eller andra tecken |
JPH02215707A (ja) | 1989-02-15 | 1990-08-28 | Chisso Corp | 皮膚化粧料 |
ES2075148T3 (es) | 1989-05-19 | 1995-10-01 | Hayashibara Biochem Lab | Acido alfa-glicosil-l-ascorbico, y su preparacion y usos. |
EP0416250A3 (en) | 1989-08-01 | 1991-08-28 | The Research Foundation Of State University Of New York | N-acylurea and o-acylisourea derivatives of hyaluronic acid |
US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
CA2023922A1 (en) | 1989-09-05 | 1991-03-06 | James M. Curtis | Method of manufacturing an implantable article provided with a micropillared surface |
JP2832848B2 (ja) | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶2―O―α―D―グルコピラノシル―L―アスコルビン酸とその製造方法並びに用途 |
US4996787A (en) * | 1990-05-29 | 1991-03-05 | Jack N. Holcomb | SigSauer pistol with concealed radio transmitter |
US5143724A (en) | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
US5246698A (en) | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
US5283671A (en) * | 1991-02-20 | 1994-02-01 | Stewart John R | Method and apparatus for converting RGB digital data to optimized CMYK digital data |
JP3115625B2 (ja) | 1991-03-30 | 2000-12-11 | 帝國製薬株式会社 | リドカイン含有外用貼付剤 |
US5314874A (en) | 1991-04-19 | 1994-05-24 | Koken Co., Ltd. | Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen |
DE4200080A1 (de) | 1992-01-03 | 1993-09-30 | Reinmueller Johannes | Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung |
JP3267972B2 (ja) | 1992-02-28 | 2002-03-25 | コラーゲン コーポレイション | 高濃度均質化コラーゲン組成物 |
IT1260154B (it) | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
WO1994017227A1 (en) | 1993-01-20 | 1994-08-04 | E.R. Squibb And Sons, Inc. | Fibres |
JP2995090B2 (ja) | 1993-03-19 | 1999-12-27 | キユー・メド・アクチエボラーグ | 組織増大のための組成物および方法 |
US5531716A (en) | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
US5616568A (en) | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
CA2146090C (en) | 1994-05-10 | 1998-11-24 | Mark E. Mitchell | Apparatus and method of mixing materials in a sterile environment |
US5616689A (en) | 1994-07-13 | 1997-04-01 | Collagen Corporation | Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation |
AU706434B2 (en) | 1994-10-18 | 1999-06-17 | Ethicon Inc. | Injectable liquid copolymers for soft tissue repair and augmentation |
US20050186673A1 (en) | 1995-02-22 | 2005-08-25 | Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie | Collagen carrier of therapeutic genetic material, and method |
US5972326A (en) | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
US5612027A (en) | 1995-04-18 | 1997-03-18 | Galin; Miles A. | Controlled release of miotic and mydriatic drugs in the anterior chamber |
FR2733427B1 (fr) | 1995-04-25 | 2001-05-25 | W K Et Associes | Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique |
FR2733426B1 (fr) | 1995-04-25 | 1997-07-18 | Debacker Yves | Dispositif medical pour le comblement des deformations du volume de la peau telles que rides et cicatrices par injection de 2 formes physico-chimiques differentes d'un polymere biologique |
US6214331B1 (en) | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
US6284284B1 (en) | 1995-06-06 | 2001-09-04 | Advanced Tissue Sciences, Inc. | Compositions and methods for production and use of an injectable naturally secreted extracellular matrix |
US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
US5571503A (en) | 1995-08-01 | 1996-11-05 | Mausner; Jack | Anti-pollution cosmetic composition |
US6007843A (en) | 1995-09-29 | 1999-12-28 | Lam Pharmaceuticals Corp. | Sustained release delivery system |
US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
IT1277707B1 (it) | 1995-12-22 | 1997-11-11 | Chemedica Sa | Formulazione oftalmica a base di ialuronato di sodio per uso nella chirurgia oculare |
US5980948A (en) | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
IT1287967B1 (it) | 1996-10-17 | 1998-09-10 | Fidia Spa In Amministrazione S | Preparazioni farmaceutiche per uso anestetico locale |
FR2759577B1 (fr) | 1997-02-17 | 1999-08-06 | Corneal Ind | Implant de sclerectomie profonde |
FR2759576B1 (fr) | 1997-02-17 | 1999-08-06 | Corneal Ind | Implant de sclero-keratectomie pre-descemetique |
US5935164A (en) | 1997-02-25 | 1999-08-10 | Pmt Corporaton | Laminated prosthesis and method of manufacture |
FR2764514B1 (fr) | 1997-06-13 | 1999-09-03 | Biopharmex Holding Sa | Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique |
US7192984B2 (en) | 1997-06-17 | 2007-03-20 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use as dermal fillers |
US6391336B1 (en) | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
FR2778336A1 (fr) | 1998-05-11 | 1999-11-12 | Jean Pierre Perraud | Implant injectable en sous-cutane et en sous-gingival resorbable a base de maltodextrine micro-encapsulee et resorbable en un temps determine |
FR2780730B1 (fr) | 1998-07-01 | 2000-10-13 | Corneal Ind | Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique |
ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
IT1303735B1 (it) | 1998-11-11 | 2001-02-23 | Falorni Italia Farmaceutici S | Acidi ialuronici reticolati e loro usi medici. |
IT1303738B1 (it) | 1998-11-11 | 2001-02-23 | Aquisitio S P A | Processo di reticolazione di polisaccaridi carbossilati. |
US20020016637A1 (en) * | 1998-12-16 | 2002-02-07 | Mark A. Anton | Soft tissue filler |
DK172900B1 (da) | 1998-12-18 | 1999-09-27 | Per Julius Nielsen | Præparat samt kit til brug ved intraoculære operationer |
GB9902412D0 (en) | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
GB9902652D0 (en) | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
US6767928B1 (en) | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
CN1229685C (zh) * | 1999-12-16 | 2005-11-30 | 株式会社尼康 | 卡口固定架 |
US6521223B1 (en) | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
US6682760B2 (en) | 2000-04-18 | 2004-01-27 | Colbar R&D Ltd. | Cross-linked collagen matrices and methods for their preparation |
KR20010096388A (ko) | 2000-04-19 | 2001-11-07 | 진세훈 | 귀두확대성형재료 및 이 재료를 이용한 귀두의 확대시술방법 |
FR2811671B1 (fr) | 2000-07-17 | 2003-02-28 | Corneal Ind | Hydrogel de polymere(s), resistant a la biodegration, preparation et utilisation a titre de support de regeneration tissulaire |
FR2811996B1 (fr) | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
WO2002009792A1 (en) | 2000-07-28 | 2002-02-07 | Anika Therapeutics, Inc. | Bioabsorbable composites of derivatized hyaluronic acid |
US6773723B1 (en) | 2000-08-30 | 2004-08-10 | Depuy Acromed, Inc. | Collagen/polysaccharide bilayer matrix |
US6620196B1 (en) | 2000-08-30 | 2003-09-16 | Sdgi Holdings, Inc. | Intervertebral disc nucleus implants and methods |
JP4187917B2 (ja) | 2000-09-08 | 2008-11-26 | 独立行政法人科学技術振興機構 | 組織再生マトリックス用グリコサミノグリカン−コラーゲン複合体の製造方法 |
US6924273B2 (en) | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
AU2001294459A1 (en) | 2000-10-06 | 2002-04-15 | Jagotec Ag | A controlled-release, parenterally administrable microparticle preparation |
KR100375299B1 (ko) | 2000-10-10 | 2003-03-10 | 주식회사 엘지생명과학 | 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법 |
WO2003053325A2 (en) | 2000-12-13 | 2003-07-03 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
US6979440B2 (en) | 2001-01-29 | 2005-12-27 | Salvona, Llc | Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric |
US7119062B1 (en) | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
CA2445086C (en) * | 2001-05-01 | 2008-04-08 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions |
TW574301B (en) | 2001-05-02 | 2004-02-01 | Ind Tech Res Inst | Manufacturing method of epoxide crosslinked polysaccharides matrix |
US20050227936A1 (en) | 2001-05-18 | 2005-10-13 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
EP1411861B1 (en) | 2001-06-29 | 2012-04-04 | Medgraft Microtech, Inc. | Biodegradable injectable implants and related methods of manufacture and use |
US6749841B2 (en) | 2001-07-26 | 2004-06-15 | Revlon Consumer Products Corporation | Stabilized aqueous acidic antiperspirant compositions and related methods |
JP4230135B2 (ja) | 2001-08-21 | 2009-02-25 | 独立行政法人科学技術振興機構 | 多官能性架橋剤によって架橋したグリコサミノグリカン−コラーゲン複合体の製造法 |
US20060189516A1 (en) | 2002-02-19 | 2006-08-24 | Industrial Technology Research Institute | Method for producing cross-linked hyaluronic acid-protein bio-composites |
JP3916516B2 (ja) | 2002-06-10 | 2007-05-16 | 独立行政法人科学技術振興機構 | 硬組織−軟組織界面再生用足場材料 |
US6780366B2 (en) | 2002-08-15 | 2004-08-24 | Mentor Corporation | Drip retainer |
KR100523953B1 (ko) | 2002-08-27 | 2005-10-25 | 주식회사 엘지생명과학 | 천연다당류와 히알루론산의 마이크로비드 및 이의 제조 방법 |
KR100507545B1 (ko) | 2002-09-03 | 2005-08-09 | 주식회사 엘지생명과학 | 히알루론산 유도체 및 그의 제조방법 |
US20040127932A1 (en) | 2002-09-12 | 2004-07-01 | Shah Tilak M. | Dip-molded polymeric medical devices with reverse thickness gradient, and method of making same |
DE10246340A1 (de) | 2002-10-04 | 2004-04-29 | Wohlrab, David, Dr. | Kombinationspräparat aus Hyaluronsäure und mindestens einem Lokalanästhetikum und dessen Verwendung |
US20040101959A1 (en) * | 2002-11-21 | 2004-05-27 | Olga Marko | Treatment of tissue with undifferentiated mesenchymal cells |
CN1732022A (zh) | 2002-12-30 | 2006-02-08 | 血管技术国际股份公司 | 含有丝的支架移植物 |
TWI251596B (en) | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
AU2003206922A1 (en) | 2003-02-19 | 2004-09-09 | Aventis Pharmaceuticals Holdings Inc. | Composition and method for intradermal soft tissue augmentation |
JP2006521180A (ja) | 2003-03-25 | 2006-09-21 | バイオキュア・インコーポレーテッド | ヒドロゲル糸による医療装置 |
FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
AU2003901834A0 (en) | 2003-04-17 | 2003-05-01 | Clearcoll Pty Ltd | Cross-linked polysaccharide compositions |
JP2004323453A (ja) | 2003-04-25 | 2004-11-18 | Chisso Corp | 分解性ゲル及びその製造法 |
KR100931551B1 (ko) | 2003-05-13 | 2009-12-14 | 미마스 한도타이 고교 가부시키가이샤 | 웨이퍼 디마운트 방법, 웨이퍼 디마운트 장치 및 웨이퍼디마운트 이송기 |
DE10323794A1 (de) * | 2003-05-23 | 2004-12-09 | Dr. Suwelack Skin & Health Care Ag | Verfahren zur Herstellung von Alginat-haltigen porösen Formkörpern |
BRPI0413086A (pt) * | 2003-07-30 | 2006-10-03 | Anteis Sa | matriz complexa, utilização da mesma, e processo de preparação de uma matriz biocompatìvel pouco biodegradável |
EP1681306B1 (en) | 2003-10-29 | 2013-02-20 | Teijin Limited | Hyaluronic acid compound, hydrogel thereof and material for treating joint |
CA2536041A1 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
US20060141049A1 (en) | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
US20090148527A1 (en) | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
JP2007513650A (ja) | 2003-11-20 | 2007-05-31 | アンジオテック インターナショナル アーゲー | 移植可能なセンサーおよび移植可能なポンプならびに瘢痕化抑制剤 |
US8124120B2 (en) | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
US8524213B2 (en) | 2003-12-30 | 2013-09-03 | Genzyme Corporation | Polymeric materials, their preparation and use |
US20050142152A1 (en) | 2003-12-30 | 2005-06-30 | Leshchiner Adelya K. | Polymeric materials, their preparation and use |
DE102004002001A1 (de) * | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
US7552442B1 (en) | 2004-01-27 | 2009-06-23 | Honeywell International Inc. | Military data link integration apparatus and method |
CA2536096A1 (en) | 2004-01-30 | 2005-08-18 | Angiotech International Ag | Compositions and methods for treating contracture |
FR2865737B1 (fr) | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
US8288362B2 (en) | 2004-05-07 | 2012-10-16 | S.K. Pharmaceuticals, Inc. | Stabilized glycosaminoglycan preparations and related methods |
EP1753787B1 (en) | 2004-05-20 | 2016-10-19 | Mentor Worldwide LLC | Method of covalently linking hyaluronan and chitosan |
CA2567532C (en) * | 2004-05-20 | 2013-10-01 | Mentor Corporation | Methods for making injectable polymer hydrogels |
WO2006002050A1 (en) | 2004-06-15 | 2006-01-05 | Encore Therapeutics, Inc. | Phospholipid compositions and methods for their preparation and use |
US20080124400A1 (en) | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
US20060040894A1 (en) | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid |
US20060040895A1 (en) | 2004-08-19 | 2006-02-23 | Kipling Thacker | Aesthetic use of hyaluronan |
US20060058238A1 (en) * | 2004-09-15 | 2006-03-16 | Lee Laurent-Applegate | Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
US7414021B2 (en) | 2004-10-01 | 2008-08-19 | Vincent Carmine Giampapa | Method and composition for restoration of age related tissue loss in the face or selected areas of the body |
KR100762928B1 (ko) | 2004-10-29 | 2007-10-04 | 재단법인서울대학교산학협력재단 | 견 피브로인 나노섬유로 이루어진 부직포 형태의 골조직유도 재생용 차폐막 및 그 제조방법 |
US20060105022A1 (en) | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | Process for preparing crosslinked hyaluronic acid gel |
US8481080B2 (en) | 2004-11-24 | 2013-07-09 | Novozymes Biopolymer A/S | Method of cross-linking hyaluronic acid with divinulsulfone |
FR2878444B1 (fr) | 2004-11-30 | 2008-04-25 | Corneal Ind Soc Par Actions Si | Solutions viscoelastiques renfermant du hyaluronate de sodiu et de l'hydroxypropylmethylcellulose, preparation et utilisations |
WO2006067608A1 (en) | 2004-12-22 | 2006-06-29 | Laboratoire Medidom S.A. | Aqueous formulations based on sodium hyaluronate for parenteral use |
WO2006102676A1 (en) | 2005-03-23 | 2006-09-28 | Tissue Engineering Refraction, Inc. | Injectable polyethylene oxide dermal fillers and related devices |
EP1893174A2 (en) | 2005-05-10 | 2008-03-05 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
EP1726299A3 (en) | 2005-05-27 | 2007-04-18 | StratoSphere Pharma AB | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
US7491709B2 (en) | 2005-07-01 | 2009-02-17 | Wayne Carey | Treatment with hyaluronic acid |
WO2007018124A1 (ja) | 2005-08-11 | 2007-02-15 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | コラーゲン産生増強剤とその用途 |
JP4982718B2 (ja) | 2005-08-31 | 2012-07-25 | 株式会社林原 | 美肌用の経口摂取用組成物 |
EP1951762B1 (en) | 2005-10-03 | 2018-02-07 | PINSKY, Mark A. | Compositions and methods for improved skin care |
EP1968614A2 (en) | 2005-12-14 | 2008-09-17 | Anika Therapeutics Inc. | Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid |
WO2007070617A1 (en) | 2005-12-14 | 2007-06-21 | Anika Therapeutics, Inc. | Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects |
FR2894827B1 (fr) | 2005-12-21 | 2010-10-29 | Galderma Res & Dev | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation,et leurs utilisations |
FR2895907B1 (fr) | 2006-01-06 | 2012-06-01 | Anteis Sa | Gel viscoelastique a usage dermatologique |
US20070184087A1 (en) | 2006-02-06 | 2007-08-09 | Bioform Medical, Inc. | Polysaccharide compositions for use in tissue augmentation |
US20070212385A1 (en) | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
JP2009529967A (ja) | 2006-03-15 | 2009-08-27 | サーモディクス,インコーポレイティド | 天然生分解性ポリサッカライドの疎水性誘導体及びそれらの使用 |
FR2900575B1 (fr) * | 2006-05-05 | 2008-10-17 | Anteis Sa | Gel biocompatible a liberation controlee, son procede de preparation et son utilisation |
US8378064B2 (en) | 2006-05-19 | 2013-02-19 | Trustees Of Boston University | Hydrophilic polymers as medical lubricants and gels |
US20070298005A1 (en) | 2006-06-22 | 2007-12-27 | Marie-Josee Thibault | Injectable composition for treatment of skin defects or deformations |
WO2008003321A2 (en) | 2006-07-07 | 2008-01-10 | Novozymes Biopolymer A/S | Compositions with several hyaluronic acid fractions for cosmetic use |
JP4557939B2 (ja) | 2006-07-18 | 2010-10-06 | 株式会社ジェイテック | X線ミラーの高精度姿勢制御法およびx線ミラー |
US20100035838A1 (en) | 2006-09-19 | 2010-02-11 | Geoffrey Kenneth Heber | Cross-linked polysaccharide gels |
FR2908415B1 (fr) | 2006-11-10 | 2009-01-23 | Abr Dev Sarl | Acide hyaluronique reticule et son procede de preparation |
FR2909560B1 (fr) | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
EP2121026B1 (en) | 2006-12-11 | 2017-06-28 | CHIT2GEL Ltd. | Novel injectable chitosan mixtures forming hydrogels |
KR100759091B1 (ko) | 2006-12-13 | 2007-09-17 | 조강선 | 피부 충전제 조성물 |
ATE545436T1 (de) | 2006-12-22 | 2012-03-15 | Croma Pharma Ges M B H | Verwendung von thiolierten polysacchariden zum gewebeaufbau |
WO2008088922A2 (en) | 2007-01-19 | 2008-07-24 | Genentech, Inc. | Prevention of hydrogel viscosity loss |
CA2677498C (en) | 2007-02-05 | 2016-05-17 | Carbylan Biosurgery, Inc. | Polymer formulations for delivery of bioactive agents |
WO2008098007A1 (en) | 2007-02-05 | 2008-08-14 | Freedom-2, Inc. | Tissue fillers and methods of using the same |
US7776840B2 (en) | 2007-02-21 | 2010-08-17 | Cutanea Life Sciences, Inc. | Methods of use of biomaterial and injectable implant containing biomaterial |
US7939578B2 (en) | 2007-02-23 | 2011-05-10 | 3M Innovative Properties Company | Polymeric fibers and methods of making |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
US20100323985A1 (en) | 2007-05-11 | 2010-12-23 | Marc Moutet | Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same |
EP2155149A2 (fr) | 2007-05-11 | 2010-02-24 | Galderma Research & Development | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations |
US20080293637A1 (en) | 2007-05-23 | 2008-11-27 | Allergan, Inc. | Cross-linked collagen and uses thereof |
JP2010528039A (ja) | 2007-05-23 | 2010-08-19 | アラーガン、インコーポレイテッド | 被覆されたヒアルロン酸粒子 |
WO2008157608A1 (en) | 2007-06-18 | 2008-12-24 | Cartlix, Inc. | Composite scaffolds for tissue regeneration |
US9011894B2 (en) | 2007-06-29 | 2015-04-21 | Carbylan Therapeutics, Inc. | Sterile hyaluronic acid polymer compositions and related methods |
CA2694700C (en) | 2007-07-27 | 2015-04-14 | Humacyte, Inc. | Compositions and methods for soft tissue augmentation |
SI2182960T1 (sl) | 2007-07-27 | 2014-07-31 | Galderma Laboratories Inc. | Spojine, formulacije in postopki za zmanjĺ anje koĺ˝nih gub, meäśkanja in poveĺ anja |
US20120071437A1 (en) | 2007-07-30 | 2012-03-22 | Allergan, Inc. | Tunable crosslinked polysaccharide compositions |
US20110077737A1 (en) | 2007-07-30 | 2011-03-31 | Allergan, Inc. | Tunably Crosslinked Polysaccharide Compositions |
US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
US8455459B2 (en) | 2007-08-02 | 2013-06-04 | Medicis Pharmaceutical Corporation | Method of applying an injectable filler |
FR2920000B1 (fr) | 2007-08-13 | 2010-01-29 | Oreal | Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement |
CA2734577A1 (en) | 2007-08-16 | 2009-02-26 | Carnegie Mellon University | Inflammation-regulating compositions and methods |
KR100813224B1 (ko) | 2007-08-24 | 2008-03-13 | 한양대학교 산학협력단 | 단백질 약물전달용 온도 가역성 코아세르베이트 조합 겔 |
FR2920968B1 (fr) | 2007-09-14 | 2009-11-13 | Oreal | Procede cosmetique de traitement esthetique et/ou reparateur de la peau |
US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
US7910134B2 (en) | 2007-10-29 | 2011-03-22 | Ayman Boutros | Alloplastic injectable dermal filler and methods of use thereof |
JP5035900B2 (ja) | 2007-11-21 | 2012-09-26 | 株式会社アイ・エイチ・アイ マリンユナイテッド | 温度分布履歴推定方法 |
US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
US20090143348A1 (en) | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
US8394784B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
US9161970B2 (en) | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
EP2222270B1 (en) | 2007-12-26 | 2018-11-14 | Mark A. Pinsky | Collagen formulations for improved skin care |
US20090291986A1 (en) | 2008-05-22 | 2009-11-26 | Apostolos Pappas | Composition and method of treating facial skin defect |
US20090297632A1 (en) | 2008-06-02 | 2009-12-03 | Waugh Jacob M | Device, Methods and Compositions to Alter Light Interplay with Skin |
WO2010003797A1 (en) | 2008-07-09 | 2010-01-14 | Novozymes Biopharma Dk A/S | Hyaluronic acid for corneal wound healing |
US20130102563A1 (en) * | 2008-08-04 | 2013-04-25 | Allergan, Inc. | Dermal filler with lidocaine |
US8450475B2 (en) | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
EP3184552B1 (en) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Threads of hyaluronic acid, methods of making thereof and uses thereof |
EP2341953B1 (en) | 2008-09-04 | 2018-11-21 | The General Hospital Corporation | Hydrogels for vocal cord and soft tissue augmentation and repair |
GB0816496D0 (en) | 2008-09-10 | 2008-10-15 | Zhao Xiaobin | Hyaluronic acid cryogel |
JP5683957B2 (ja) | 2008-09-30 | 2015-03-11 | 電気化学工業株式会社 | 光安定化された医薬組成物 |
US20100098794A1 (en) | 2008-10-17 | 2010-04-22 | Armand Gerard | Topical anti-wrinkle and anti-aging moisturizing cream |
US20100111919A1 (en) | 2008-10-31 | 2010-05-06 | Tyco Healthcare Group Lp | Delayed gelation compositions and methods of use |
WO2010053918A1 (en) | 2008-11-05 | 2010-05-14 | Hancock Jaffe Laboratories, Inc. | Composite containing collagen and elastin as a dermal expander and tissue filler |
DK2365829T3 (en) | 2008-11-07 | 2017-07-31 | Klox Tech Inc | COMBINATION OF AN OXIDANT AND PHOTO ACTIVATOR FOR HEALING OF WOES |
FR2938187B1 (fr) | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
ITRM20080636A1 (it) | 2008-11-28 | 2010-05-29 | Univ Palermo | Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. |
US20100136070A1 (en) | 2008-12-03 | 2010-06-03 | Jakk Group, Inc. | Methods, devices, and compositions for dermal filling |
SE533818C2 (sv) | 2009-02-04 | 2011-01-25 | Roxtec Ab | Excentrisk del av en rör- eller kabelgenomföring |
PL2236523T3 (pl) | 2009-03-30 | 2018-07-31 | Scivision Biotech Inc. | Sposób wytwarzania usieciowanego kwasu hialuronowego |
EP2413894B1 (en) | 2009-04-02 | 2017-01-04 | Allergan, Inc. | Hair-like shaped hydrogels for soft tissue augmentation |
US9371402B2 (en) | 2009-04-09 | 2016-06-21 | Scivision Biotech Inc. | Method for producing cross-linked hyaluronic acid |
KR101453601B1 (ko) | 2009-05-29 | 2014-10-22 | 갈데르마 리써어치 앤드 디벨로프먼트 | 주입으로 인한 피부 반응 감소를 위한 필러와 아드레날린 수용체 작용제의 주사가능한 조합 |
IT1395392B1 (it) | 2009-08-27 | 2012-09-14 | Fidia Farmaceutici | Geli viscoelastici come nuovi filler |
US8657795B2 (en) | 2009-12-30 | 2014-02-25 | Cook Medical Technologies Llc | Vascular port |
US20110171286A1 (en) | 2010-01-13 | 2011-07-14 | Allergan, Inc. | Hyaluronic acid compositions for dermatological use |
US20110171311A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
DE102010009460A1 (de) | 2010-02-26 | 2011-09-01 | Siemens Aktiengesellschaft | Verfahren zur Übermittlung mehrerer medizinischer Bilddatensätze und System zur Verwaltung von Bilddatensätzen |
NZ602405A (en) | 2010-03-12 | 2014-12-24 | Allergan Ind Sas | A fluid composition comprising a hyaluronan polymer and mannitol for improving skin conditions |
AU2011229730B2 (en) | 2010-03-22 | 2016-01-07 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
CA2815141A1 (en) | 2010-10-20 | 2012-04-26 | Tautona Group Lp | Threads of cross-linked hyaluronic acid and methods of preparation and use thereof |
US9299476B2 (en) | 2010-10-22 | 2016-03-29 | Newsouth Innovations Pty Limited | Polymeric material |
FR2968306B1 (fr) | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
FR2968305B1 (fr) | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
US20120142628A1 (en) * | 2010-12-07 | 2012-06-07 | Allergan, Inc. | Methods for treating crepitus |
US8793408B2 (en) | 2010-12-21 | 2014-07-29 | Nikon Corporation | Electronic device and program |
US20140178512A1 (en) | 2011-02-22 | 2014-06-26 | Merz Pharma Gmbh & Co. Kgaa | In situ formation of a filler |
US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
EP3536307B1 (en) | 2011-06-03 | 2021-10-20 | ALLERGAN Industrie, SAS | Dermal filler compositions including antioxidants |
US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
US20130116411A1 (en) | 2011-09-06 | 2013-05-09 | Allergan, Inc. | Methods of making hyaluronic acid/collagen compositions |
US20130116190A1 (en) | 2011-09-06 | 2013-05-09 | Allergan, Inc. | Hyaluronic acid-collagen matrices for tissue engineering |
US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
US20140011980A1 (en) | 2012-07-03 | 2014-01-09 | Allergan, Inc. | Methods for sterilizing compositions and resulting compositions |
US9627808B2 (en) | 2015-04-13 | 2017-04-18 | Tyco Electronics Brasil Ltda | One piece connector with integral latching members |
-
2009
- 2009-02-26 US US12/393,768 patent/US8450475B2/en active Active
- 2009-02-26 US US12/393,884 patent/US8357795B2/en active Active
- 2009-03-02 ES ES09785852.6T patent/ES2622708T3/es active Active
- 2009-03-02 DK DK09785850.0T patent/DK2326302T3/en active
- 2009-03-02 JP JP2011521649A patent/JP5670899B2/ja active Active
- 2009-03-02 KR KR1020117005032A patent/KR101672562B1/ko active IP Right Grant
- 2009-03-02 AU AU2009278883A patent/AU2009278883B2/en active Active
- 2009-03-02 ES ES13004017T patent/ES2780190T3/es active Active
- 2009-03-02 PL PL13004017T patent/PL2674147T3/pl unknown
- 2009-03-02 ES ES09785850.0T patent/ES2599763T3/es active Active
- 2009-03-02 MX MX2011001322A patent/MX2011001322A/es active IP Right Grant
- 2009-03-02 PL PL09785850T patent/PL2326302T3/pl unknown
- 2009-03-02 SI SI200931640A patent/SI2323617T1/sl unknown
- 2009-03-02 EP EP16202632.2A patent/EP3205332A1/en not_active Withdrawn
- 2009-03-02 BR BRPI0917573-3A patent/BRPI0917573B1/pt active IP Right Grant
- 2009-03-02 MX MX2015001317A patent/MX342613B/es unknown
- 2009-03-02 JP JP2011521650A patent/JP5670900B2/ja active Active
- 2009-03-02 DK DK09785852.6T patent/DK2323617T3/en active
- 2009-03-02 MX MX2011001321A patent/MX2011001321A/es active IP Right Grant
- 2009-03-02 CN CN2009801391620A patent/CN102170855B/zh active Active
- 2009-03-02 PT PT97858500T patent/PT2326302T/pt unknown
- 2009-03-02 BR BRPI0917588D patent/BRPI0917588A2/pt unknown
- 2009-03-02 WO PCT/IB2009/005048 patent/WO2010015901A1/en active Application Filing
- 2009-03-02 RU RU2011107878/15A patent/RU2496473C2/ru active
- 2009-03-02 CA CA3112106A patent/CA3112106C/en active Active
- 2009-03-02 PT PT97858526T patent/PT2323617T/pt unknown
- 2009-03-02 CA CA3023168A patent/CA3023168C/en active Active
- 2009-03-02 RU RU2011107877/15A patent/RU2496474C2/ru active
- 2009-03-02 DK DK13004017.3T patent/DK2674147T3/da active
- 2009-03-02 EP EP09785852.6A patent/EP2323617B1/en not_active Revoked
- 2009-03-02 EP EP13004017.3A patent/EP2674147B1/en not_active Revoked
- 2009-03-02 CN CN2009801391635A patent/CN102170856B/zh active Active
- 2009-03-02 EP EP09785850.0A patent/EP2326302B1/en not_active Revoked
- 2009-03-02 CN CN201310094949.8A patent/CN103285423B/zh active Active
- 2009-03-02 KR KR1020117005031A patent/KR101747441B1/ko active IP Right Grant
- 2009-03-02 EP EP21181448.8A patent/EP3988082A1/en active Pending
- 2009-03-02 CA CA2732788A patent/CA2732788C/en active Active
- 2009-03-02 CA CA2732928A patent/CA2732928A1/en not_active Abandoned
- 2009-03-02 PL PL09785852T patent/PL2323617T3/pl unknown
- 2009-03-02 SG SG10201505441TA patent/SG10201505441TA/en unknown
- 2009-03-02 WO PCT/IB2009/005046 patent/WO2010015900A1/en active Application Filing
- 2009-03-02 HU HUE09785850A patent/HUE031483T2/hu unknown
- 2009-03-02 SG SG10202104803SA patent/SG10202104803SA/en unknown
- 2009-03-02 HU HUE13004017A patent/HUE048366T2/hu unknown
- 2009-03-02 BR BRPI0917588-1A patent/BRPI0917588B1/pt active IP Right Grant
- 2009-03-02 AU AU2009278884A patent/AU2009278884B2/en active Active
- 2009-03-02 HU HUE09785852A patent/HUE031598T2/hu unknown
- 2009-03-02 SI SI200931541A patent/SI2326302T1/sl unknown
- 2009-03-02 CA CA3209175A patent/CA3209175A1/en active Pending
- 2009-03-02 EP EP19205326.2A patent/EP3662889A1/en active Pending
- 2009-03-02 CA CA2944734A patent/CA2944734C/en active Active
-
2010
- 2010-12-16 US US12/970,707 patent/US20110118206A1/en not_active Abandoned
-
2011
- 2011-10-21 HK HK11111393.7A patent/HK1156883A1/zh unknown
-
2012
- 2012-03-13 US US13/419,079 patent/US8822676B2/en active Active
- 2012-10-16 US US13/653,266 patent/US9089518B2/en active Active
- 2012-10-16 US US13/653,251 patent/US9089517B2/en active Active
-
2013
- 2013-01-21 US US13/746,170 patent/US9238013B2/en active Active
- 2013-05-09 US US13/891,052 patent/US9358322B2/en active Active
-
2014
- 2014-01-31 US US14/170,310 patent/US20140148406A1/en not_active Abandoned
- 2014-03-11 HK HK14102417.5A patent/HK1189518A1/xx unknown
- 2014-04-01 US US14/242,752 patent/US20140213547A1/en not_active Abandoned
- 2014-04-01 US US14/242,747 patent/US9089519B2/en active Active
- 2014-09-05 JP JP2014181635A patent/JP5808848B2/ja active Active
- 2014-09-05 JP JP2014181641A patent/JP2014237719A/ja active Pending
- 2014-10-24 US US14/523,641 patent/US20150045321A1/en not_active Abandoned
-
2015
- 2015-06-29 US US14/754,504 patent/US20150297790A1/en not_active Abandoned
- 2015-09-09 JP JP2015177452A patent/JP2016000350A/ja active Pending
-
2016
- 2016-06-06 US US15/173,850 patent/US10328180B2/en active Active
- 2016-10-21 CY CY20161101063T patent/CY1118281T1/el unknown
-
2017
- 2017-02-27 US US15/443,080 patent/US20190134275A9/en not_active Abandoned
- 2017-04-07 CY CY20171100413T patent/CY1118821T1/el unknown
-
2018
- 2018-11-09 US US16/186,448 patent/US10485896B2/en active Active
- 2018-11-09 US US16/186,451 patent/US10391202B2/en active Active
-
2019
- 2019-07-24 US US16/521,547 patent/US11173232B2/en active Active
- 2019-07-29 US US16/525,569 patent/US20190350832A1/en not_active Abandoned
- 2019-11-25 US US16/695,001 patent/US11020512B2/en active Active
-
2021
- 2021-05-26 US US17/331,543 patent/US20210283313A1/en active Pending
- 2021-11-15 US US17/527,025 patent/US20220313870A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2011107877A (ru) | Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты | |
Suo et al. | Interpenetrating polymer network hydrogels composed of chitosan and photocrosslinkable gelatin with enhanced mechanical properties for tissue engineering | |
Liu et al. | Biocompatible, high‐performance, wet‐adhesive, stretchable all‐hydrogel supercapacitor implant based on PANI@ rGO/Mxenes electrode and hydrogel electrolyte | |
Chen et al. | High-strength, tough, and self-healing hydrogel based on carboxymethyl cellulose | |
RU2013125786A (ru) | Способ получения поперечно-сшитого геля | |
RU2009107105A (ru) | Быстродействующий герметик и способы его применения и изготовления | |
BRPI0507294B8 (pt) | processo de fabricação de um gel reticulado biocompatível, gel, e, utilização do gel | |
RU2010125704A (ru) | Состав полисахаридного геля | |
DE602004028455D1 (de) | Vernetzte polysaccharidzusammensetzung | |
JP2014237719A5 (ru) | ||
MX2020001721A (es) | Celulosa microfibrilada como un agente de reticulacion. | |
ITTO20040918A1 (it) | Idrogel polimerici superassorbenti biodegradabili e procedimento per la loro preparazione | |
ATE407975T1 (de) | Die viskosität von polyalkylenglykol erhöhende polymere formulierungen | |
MX2012002364A (es) | Geles viscoelasticos como rellenos novedosos. | |
CN110028681A (zh) | 三重形状记忆聚两性电解质水凝胶的制备方法和使用方法 | |
Malik et al. | Nano-structured dynamic Schiff base cues as robust self-healing polymers for biomedical and tissue engineering applications: A review | |
CN101153061A (zh) | 一种透明质酸及其二次交联形成凝胶的方法 | |
CN110157012A (zh) | 一种高强度高韧性明胶基水凝胶的制备方法 | |
BR112021020596A2 (pt) | Métodos de modificação de películas polímeras de barreira | |
RU2017131027A (ru) | Композиции и способы для улучшения внешнего вида кожи | |
Maleki et al. | Green semi-IPN hydrogels by direct utilization of crude wood hydrolysates | |
CN103480034A (zh) | 辐照交联壳聚糖/明胶/聚乙烯醇水凝胶敷料及其制备方法和应用 | |
CN110172162A (zh) | 基于琼脂的自修复仿生低摩擦水凝胶关节软骨的制备方法 | |
CN113527583A (zh) | 一种医用抗菌冷敷水凝胶及其制备方法 | |
CN107823700A (zh) | 止血用纤维素/壳聚糖复合微球的制备方法 |