BRPI0507294B8 - processo de fabricação de um gel reticulado biocompatível, gel, e, utilização do gel - Google Patents
processo de fabricação de um gel reticulado biocompatível, gel, e, utilização do gelInfo
- Publication number
- BRPI0507294B8 BRPI0507294B8 BRPI0507294A BRPI0507294A BRPI0507294B8 BR PI0507294 B8 BRPI0507294 B8 BR PI0507294B8 BR PI0507294 A BRPI0507294 A BR PI0507294A BR PI0507294 A BRPI0507294 A BR PI0507294A BR PI0507294 B8 BRPI0507294 B8 BR PI0507294B8
- Authority
- BR
- Brazil
- Prior art keywords
- gel
- crosslinking
- cross
- utilization
- manufacturing process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/245—Differential crosslinking of one polymer with one crosslinking type, e.g. surface crosslinking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
processo de fabricação de um gel reticulado biocompatível,gel,e,utilização do gel. a invenção refere-se a um processo de fabricação de um gel reticulado biocompatível que envolve as etapas: de iniciação da reticulação de uma quantidade determinada de pelo menos um polímero biocompatível em solução por adição de uma quantidade de agente reticulante, de reação de reticulação da dita quantidade de polímero, de adição de uma quantidade suplementar de polímero de massa molecular superior a 500 000 da em solução com diluição da mistura da reação de maneira a diminuir a concentração global do polímero em solução e de reticulação e de interrupção da reação de reticulação por eliminação do agente reticulante; assim como o dito gel e utilização do mesmo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0400987 | 2004-02-03 | ||
FR0400987A FR2865737B1 (fr) | 2004-02-03 | 2004-02-03 | Gel reticule biocompatible |
PCT/FR2005/000197 WO2005085329A1 (fr) | 2004-02-03 | 2005-01-31 | Gel reticule biocompatible |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0507294A BRPI0507294A (pt) | 2007-07-03 |
BRPI0507294B1 BRPI0507294B1 (pt) | 2019-02-19 |
BRPI0507294B8 true BRPI0507294B8 (pt) | 2021-07-27 |
Family
ID=34746373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507294A BRPI0507294B8 (pt) | 2004-02-03 | 2005-01-31 | processo de fabricação de um gel reticulado biocompatível, gel, e, utilização do gel |
Country Status (15)
Country | Link |
---|---|
US (1) | US8052990B2 (pt) |
EP (1) | EP1711552B1 (pt) |
JP (1) | JP5105274B2 (pt) |
KR (1) | KR101044339B1 (pt) |
CN (1) | CN100582146C (pt) |
AT (1) | ATE489420T1 (pt) |
AU (1) | AU2005219595B2 (pt) |
BR (1) | BRPI0507294B8 (pt) |
CA (1) | CA2554597C (pt) |
DE (1) | DE602005024919D1 (pt) |
ES (1) | ES2354699T3 (pt) |
FR (1) | FR2865737B1 (pt) |
PL (1) | PL1711552T3 (pt) |
RU (1) | RU2377260C2 (pt) |
WO (1) | WO2005085329A1 (pt) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1928918B1 (en) * | 2005-09-27 | 2011-11-16 | UNIVERSITE JOSEPH FOURIER - Grenoble 1 | Hydrogel functionalized with a polymerizable moiety and their uses as biosensors or bioreactors |
WO2008034176A1 (en) * | 2006-09-19 | 2008-03-27 | Ultraceuticals R & D Pty Ltd | Cross-linked polysaccharide gels |
FR2909285A1 (fr) * | 2006-12-01 | 2008-06-06 | Anteis Sa | "utilisation d'un gel anti-adhesif et anti fibrotique" |
FR2909560B1 (fr) | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
US20080287633A1 (en) * | 2007-05-18 | 2008-11-20 | Drumheller Paul D | Hydrogel Materials |
FR2918276B1 (fr) * | 2007-07-02 | 2010-01-22 | Anteis Sa | "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires" |
FR2918377B1 (fr) * | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
EP2170961A1 (de) * | 2007-07-25 | 2010-04-07 | S & V Technologies AG | Hyaluronsäuredispersion, herstellung und anwendung |
PT2818184T (pt) | 2007-11-16 | 2019-01-28 | Aclaris Therapeutics Inc | Composições e métodos para o tratamento de púrpura |
US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
FR2924615B1 (fr) * | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
FR2927255B1 (fr) * | 2008-02-07 | 2011-08-12 | Keysan Consulting | Produits injectables biocompatibles a liberation de zinc et/ou de sel de saccharide sous forme de zinc et leurs utilisations. |
US8574629B2 (en) * | 2008-08-01 | 2013-11-05 | Anteis S.A. | Injectable hydrogel with an enhanced remanence and with an enhanced ability to create volume |
US8450475B2 (en) | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
JP5722217B2 (ja) | 2008-09-02 | 2015-05-20 | アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエAllergan Holdings France S.A.S. | ヒアルロン酸および/またはその誘導体の糸、その作製方法、ならびにその使用 |
US8715266B2 (en) * | 2008-09-12 | 2014-05-06 | Aptissen Sa | Glaucoma surgery |
US9339514B2 (en) | 2008-09-12 | 2016-05-17 | Aptissen Sa | Method for treating glaucoma |
FR2938187B1 (fr) | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
FR2945293B1 (fr) * | 2009-05-11 | 2011-06-17 | Teoxane | Procede de preparation d'un gel reticule. |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
CA2792729C (en) | 2010-03-12 | 2016-06-28 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
EP2550027B2 (en) | 2010-03-22 | 2019-03-20 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
FR2962040B3 (fr) * | 2010-07-05 | 2012-08-10 | Alain Villette | Composition injectable comprenant un medicament injectable et un gel |
US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
FR2968305B1 (fr) * | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
FR2968996B1 (fr) | 2010-12-17 | 2013-04-12 | Anteis Sa | Formulation aqueuse injectable sterile utilisee en ophtalmologie |
US20140038917A1 (en) | 2011-04-19 | 2014-02-06 | Anteis S.A. | Sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint |
US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
RU2740454C2 (ru) | 2011-06-03 | 2021-01-14 | Аллерган Эндюстри, Сас | Составы кожного наполнителя, включая антиоксиданты |
US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
KR20200116168A (ko) * | 2011-09-14 | 2020-10-08 | 알러간, 인코포레이티드 | 잔주름 치료를 위한 진피 필러 조성물 |
ITAN20110138A1 (it) | 2011-10-12 | 2012-01-11 | Regenyal Lab S R L | Sintesi di un gel iniettabile multifasico a base di acido ialuronico monofasico libero e reticolato e di acido ialuronico bifasico associato con idrossiapatite con inibitore della ialuronidasi microincapsulato. |
ITMI20120732A1 (it) | 2012-05-03 | 2013-11-04 | B S Srl | Polisaccaridi reticolati a memoria di forma |
FR2991876B1 (fr) | 2012-06-13 | 2014-11-21 | Vivacy Lab | Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
MX354947B (es) * | 2012-06-15 | 2018-03-27 | Merz Pharma Gmbh & Co Kgaa | Metodo para preparar una composicion a base de acido hialuronico. |
US20140315828A1 (en) | 2013-04-22 | 2014-10-23 | Allergan, Inc. | Cross-linked silk-hyaluronic acid compositions |
FR3006689A1 (fr) | 2013-06-11 | 2014-12-12 | Benedicte Vincente Tauzin | Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu |
WO2014198406A1 (en) | 2013-06-11 | 2014-12-18 | Anteis S.A. | Method for crosslinking hyaluronic acid; method for preparing an injectable hydrogel; hydrogel obtained; use of the obtained hydrogel |
BR112015031457A2 (pt) * | 2013-06-28 | 2017-07-25 | Galderma Sa | processo para preparar um produto do ácido hialurônico reticulado |
LT3049055T (lt) | 2013-09-27 | 2018-07-25 | Anteis S.A. | Injekcinio hidrogelio, sterilizuoto karščiu, sudaryto iš hialurono rūgšties, turinčio miltelių pavidalo lidokaino ir šarminio agento, gamybos būdas |
AR099900A1 (es) | 2014-04-01 | 2016-08-24 | Merz Pharma Gmbh & Co Kgaa | Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso |
EP3620184A1 (en) | 2014-09-30 | 2020-03-11 | Allergan Industrie, SAS | Stable hydrogel compositions including additives |
FR3029928B1 (fr) | 2014-12-15 | 2018-03-09 | Teoxane | Gel reticule |
FR3037797B1 (fr) | 2015-06-24 | 2018-08-17 | Kylane Laboratoires Sa | Procede de preparation d'un hydrogel reticule injectable; hydrogel obtenu; utilisation de l'hydrogel obtenu |
ES2836473T3 (es) | 2015-06-30 | 2021-06-25 | Merz Pharma Gmbh & Co Kgaa | Método de preparación de una composición basada en ácido hialurónico |
EP3316921B1 (en) * | 2015-06-30 | 2021-05-05 | Merz Pharma GmbH & Co. KGaA | Method for producing crosslinked hyaluronic acid |
DE102015009271A1 (de) * | 2015-07-19 | 2017-01-19 | Tracey Lennemann | Neue Verwendung von Hyaluronsäure |
WO2017025635A1 (en) * | 2015-08-13 | 2017-02-16 | Newven Sprl | Composition for the treatment of joint conditions |
PL3347061T3 (pl) * | 2015-09-09 | 2021-11-22 | ETH Zürich | Hydrożele makroporowate do wstrzykiwania |
EP3162813A1 (en) | 2015-11-02 | 2017-05-03 | Merz Pharma GmbH & Co. KGaA | Process for depleting epoxide species in crosslinked poly-saccharide gel compositions and compositions obtained thereby |
RU2697671C1 (ru) | 2015-11-24 | 2019-08-16 | БиЭмАй КОРЕЯ КО., ЛТД | Композиция для инъекций гиалуроновой кислоты, содержащей производное гиалуроновой кислоты и ДНК фракцию, и ее применение |
FR3044557B1 (fr) | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
FR3047666A1 (fr) | 2016-02-15 | 2017-08-18 | Benedicte Vincente Gavard Molliard Tauzin | Composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
TWI727014B (zh) | 2016-03-24 | 2021-05-11 | 德商梅茲製藥有限兩合公司 | 修飾透明質酸與其製造方法及其用途 |
CA2961868A1 (en) * | 2016-04-08 | 2017-10-08 | Johnson & Johnson Consumer Inc. | Topical compositions containing cross-linked glycosaminoglycans |
US10300169B2 (en) | 2016-08-24 | 2019-05-28 | Allergan, Inc. | Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation |
CN106397795B (zh) * | 2016-08-31 | 2018-12-21 | 陕西佰傲再生医学有限公司 | 一种混合透明质酸凝胶及其制备方法 |
WO2018083195A1 (en) | 2016-11-03 | 2018-05-11 | Merz Pharma Gmbh & Co. Kgaa | Method for preparing hyaluronic acid dermal fillers, dermal fillers obtained thereby and their use |
PL3538066T3 (pl) | 2016-11-11 | 2022-05-02 | Anteis Sa | Wypełniacze skórne z kwasem hialuronowym usieciowane kwasem cytrynowym, sposób ich wytwarzania i ich zastosowania |
WO2018220283A1 (fr) | 2017-05-29 | 2018-12-06 | Kh Medtech Sarl | Composition injectable sterile contenant de l'acide hyaluronique reticule et de l'articaine |
JP7309716B2 (ja) | 2017-12-22 | 2023-07-18 | ガルデルマ ホールディング ソシエテ アノニム | 注入可能なゲル製品 |
WO2019155391A1 (en) | 2018-02-06 | 2019-08-15 | Regen Lab Sa | Cross-linked hyaluronic acids and combinations with prp/bmc |
US20190240335A1 (en) * | 2018-02-07 | 2019-08-08 | Promedon S.A. | Biocompatible Hydrogel Compositions |
MX2021001208A (es) | 2018-08-07 | 2021-06-15 | Merz Pharma Gmbh & Co Kgaa | Metodo para la filtracion dinamica de un hidrogel reticulado. |
LU101045B1 (en) | 2018-12-11 | 2020-06-11 | Qventis GmbH | Method for the manufacture and use of a bionic hydrogel composition for medical applications |
WO2021116069A1 (en) | 2019-12-09 | 2021-06-17 | Merz Pharma Gmbh & Co. Kgaa | Process for producing a composition comprising a crosslinked hydrogel |
EP4362993A1 (en) | 2021-06-30 | 2024-05-08 | Merz Pharma GmbH & Co. KGaA | Hyaluronic acid dermal fillers crosslinked with polyethylene glycol diglycidyl ether, method for making same and uses thereof |
CN114470333B (zh) * | 2022-03-09 | 2023-05-23 | 哈尔滨敷尔佳科技股份有限公司 | 交联重组胶原蛋白凝胶的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS5951789A (ja) * | 1982-09-18 | 1984-03-26 | Wako Pure Chem Ind Ltd | 安定化酵素 |
US4716224A (en) * | 1984-05-04 | 1987-12-29 | Seikagaku Kogyo Co. Ltd. | Crosslinked hyaluronic acid and its use |
US6174999B1 (en) * | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
AU673160B2 (en) * | 1992-02-28 | 1996-10-31 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
HUT71776A (en) * | 1994-03-21 | 1996-01-29 | Ciba Geigy Ag | Antibody conjugates with improved properties |
EP0713707A1 (en) * | 1994-11-23 | 1996-05-29 | Collagen Corporation | In situ crosslinkable, injectable collagen composition for tissue augmention |
FR2733426B1 (fr) * | 1995-04-25 | 1997-07-18 | Debacker Yves | Dispositif medical pour le comblement des deformations du volume de la peau telles que rides et cicatrices par injection de 2 formes physico-chimiques differentes d'un polymere biologique |
US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
GB9902652D0 (en) * | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
FR2811996B1 (fr) * | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
JP4135502B2 (ja) * | 2001-01-31 | 2008-08-20 | 生化学工業株式会社 | 架橋多糖スポンジ |
CA2476656C (en) * | 2002-02-21 | 2008-11-25 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
JP4958368B2 (ja) * | 2002-02-28 | 2012-06-20 | 電気化学工業株式会社 | 架橋ヒアルロン酸 |
-
2004
- 2004-02-03 FR FR0400987A patent/FR2865737B1/fr not_active Expired - Fee Related
-
2005
- 2005-01-31 RU RU2006127591/04A patent/RU2377260C2/ru active
- 2005-01-31 KR KR1020067015505A patent/KR101044339B1/ko active IP Right Grant
- 2005-01-31 DE DE602005024919T patent/DE602005024919D1/de active Active
- 2005-01-31 CA CA2554597A patent/CA2554597C/fr active Active
- 2005-01-31 EP EP05717516A patent/EP1711552B1/fr active Active
- 2005-01-31 WO PCT/FR2005/000197 patent/WO2005085329A1/fr not_active Application Discontinuation
- 2005-01-31 AU AU2005219595A patent/AU2005219595B2/en active Active
- 2005-01-31 CN CN200580003963A patent/CN100582146C/zh active Active
- 2005-01-31 AT AT05717516T patent/ATE489420T1/de active
- 2005-01-31 PL PL05717516T patent/PL1711552T3/pl unknown
- 2005-01-31 US US10/588,186 patent/US8052990B2/en active Active
- 2005-01-31 BR BRPI0507294A patent/BRPI0507294B8/pt active IP Right Grant
- 2005-01-31 ES ES05717516T patent/ES2354699T3/es active Active
- 2005-01-31 JP JP2006551875A patent/JP5105274B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
PL1711552T3 (pl) | 2011-04-29 |
CN1918219A (zh) | 2007-02-21 |
US20070196426A1 (en) | 2007-08-23 |
BRPI0507294B1 (pt) | 2019-02-19 |
CA2554597A1 (fr) | 2005-09-15 |
FR2865737B1 (fr) | 2006-03-31 |
RU2006127591A (ru) | 2008-02-10 |
JP5105274B2 (ja) | 2012-12-26 |
DE602005024919D1 (de) | 2011-01-05 |
KR101044339B1 (ko) | 2011-06-29 |
BRPI0507294A (pt) | 2007-07-03 |
CA2554597C (fr) | 2012-04-24 |
CN100582146C (zh) | 2010-01-20 |
ES2354699T3 (es) | 2011-03-17 |
EP1711552B1 (fr) | 2010-11-24 |
EP1711552A1 (fr) | 2006-10-18 |
US8052990B2 (en) | 2011-11-08 |
AU2005219595A1 (en) | 2005-09-15 |
FR2865737A1 (fr) | 2005-08-05 |
JP2007520612A (ja) | 2007-07-26 |
RU2377260C2 (ru) | 2009-12-27 |
AU2005219595B2 (en) | 2010-07-29 |
ATE489420T1 (de) | 2010-12-15 |
KR20070004611A (ko) | 2007-01-09 |
WO2005085329A1 (fr) | 2005-09-15 |
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