BR112015031457A2 - processo para preparar um produto do ácido hialurônico reticulado - Google Patents

processo para preparar um produto do ácido hialurônico reticulado

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Publication number
BR112015031457A2
BR112015031457A2 BR112015031457A BR112015031457A BR112015031457A2 BR 112015031457 A2 BR112015031457 A2 BR 112015031457A2 BR 112015031457 A BR112015031457 A BR 112015031457A BR 112015031457 A BR112015031457 A BR 112015031457A BR 112015031457 A2 BR112015031457 A2 BR 112015031457A2
Authority
BR
Brazil
Prior art keywords
cross
activated
hyaluronic acid
preparing
acid product
Prior art date
Application number
BR112015031457A
Other languages
English (en)
Inventor
Edsman Katarina
Karlsson Morgan
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa filed Critical Galderma Sa
Publication of BR112015031457A2 publication Critical patent/BR112015031457A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/244—Stepwise homogeneous crosslinking of one polymer with one crosslinking system, e.g. partial curing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

resumo processo para preparar um produto do ácido hialurônico reticulado a presente invenção se refer à reticulação eficiente do ácido hialurônico (ha) por meio de um processo de fabricação. no processo, o ha é ativado por uma reticulação inicial em uma solução aquosa. o agente de reticulação não reagido é removido do ha ativado. a reticulação do ha ativado é finalizada, sem a adição de qualquer agente de reticulação adicional, em uma suspensão de um meio de precipitação líquido e do ha ativado na forma de precipitado. os produtos resultantes do ha reticulado exibem uma razão efetiva elevada entre o reticulador e as demais propriedades favoráveis, tornando úteis os produtos como implantes e na cirurgia médica e cosmética.
BR112015031457A 2013-06-28 2014-06-05 processo para preparar um produto do ácido hialurônico reticulado BR112015031457A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2013063718 2013-06-28
PCT/EP2014/061674 WO2014206701A1 (en) 2013-06-28 2014-06-05 A process for preparing a cross-linked hyaluronic acid product

Publications (1)

Publication Number Publication Date
BR112015031457A2 true BR112015031457A2 (pt) 2017-07-25

Family

ID=48703546

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015031457A BR112015031457A2 (pt) 2013-06-28 2014-06-05 processo para preparar um produto do ácido hialurônico reticulado

Country Status (11)

Country Link
US (2) US10077320B2 (pt)
JP (1) JP6479783B2 (pt)
KR (1) KR20160025026A (pt)
CN (2) CN105473623B (pt)
AU (1) AU2014301493B2 (pt)
BR (1) BR112015031457A2 (pt)
CA (1) CA2916330A1 (pt)
HK (1) HK1224315A1 (pt)
MX (1) MX368941B (pt)
RU (1) RU2689559C2 (pt)
WO (1) WO2014206701A1 (pt)

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FR3032617B1 (fr) * 2015-02-16 2018-03-16 Kylane Laboratoires Sa Procede de preparation d un hydrogel injectable; hydrogel obtenu; utilisation de l hydrogel obtenu
WO2017016917A1 (en) * 2015-07-27 2017-02-02 Galderma Sa A process for efficient cross-linking of hyaluronic acid
EP3162813A1 (en) * 2015-11-02 2017-05-03 Merz Pharma GmbH & Co. KGaA Process for depleting epoxide species in crosslinked poly-saccharide gel compositions and compositions obtained thereby
KR20170090965A (ko) * 2016-01-29 2017-08-08 한미약품 주식회사 복합 히알루론산 가교물 및 그 제조방법
WO2017131298A1 (en) * 2016-01-29 2017-08-03 Hanmi Pharm. Co., Ltd. Combination of cross-linked hyaluronic acids and method of preparing the same
JP2020525253A (ja) 2017-06-26 2020-08-27 エヴォルヴド バイ ネイチャー インコーポレーテッド 絹−ヒアルロン酸系組織フィラー、及びそれを用いる方法
CN108395552B (zh) * 2017-12-15 2021-03-19 浙江景嘉医疗科技有限公司 一种单相交联透明质酸钠凝胶的制备方法
KR102400586B1 (ko) * 2018-12-07 2022-05-23 한미약품 주식회사 히알루론산 가교물, 히알루론산 수화 겔 및 이들의 제조방법
EP3946484B1 (en) * 2019-04-02 2023-11-15 Volumina Medical SA Composition comprising a cross-linked polyol
USD918654S1 (en) 2019-06-06 2021-05-11 Sharkninja Operating Llc Grill plate
CN112147029A (zh) * 2019-06-28 2020-12-29 杭州协合医疗用品有限公司 一种交联透明质酸钠凝胶溶胀度的测定方法
WO2021060934A1 (ko) * 2019-09-27 2021-04-01 주식회사 엘지화학 고분자 마이크로 입자의 제조방법, 고분자 마이크로 입자, 이를 포함하는 의료용 조성물, 미용 조성물, 의료 용품 및 미용 용품
KR102425496B1 (ko) * 2020-05-08 2022-07-26 주식회사 종근당 고탄성, 고점도 및 고유효 가교율을 갖는 히알루론산 가교체, 및 이의 제조방법
KR102527095B1 (ko) 2020-12-18 2023-04-28 충남대학교산학협력단 가교 처리된 히알루론산 조성물의 가교율 측정방법
KR20230153377A (ko) * 2021-03-02 2023-11-06 시매테스 중합체를 기반으로 하는 이식가능한 또는 주입가능한 생성물 및 그의 제조 방법
CN113278170B (zh) * 2021-06-15 2021-11-16 苏州大学 一种化学交联透明质酸水凝胶及其制备方法与应用

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Also Published As

Publication number Publication date
RU2016101736A (ru) 2017-08-02
JP6479783B2 (ja) 2019-03-06
CN105473623A (zh) 2016-04-06
RU2689559C2 (ru) 2019-05-28
AU2014301493A1 (en) 2016-02-11
AU2014301493B2 (en) 2018-11-29
CN105473623B (zh) 2019-10-29
WO2014206701A1 (en) 2014-12-31
CN110003360A (zh) 2019-07-12
CA2916330A1 (en) 2014-12-31
JP2016523303A (ja) 2016-08-08
KR20160025026A (ko) 2016-03-07
US20190062461A1 (en) 2019-02-28
HK1224315A1 (zh) 2017-08-18
US10077320B2 (en) 2018-09-18
US20160376382A1 (en) 2016-12-29
RU2016101736A3 (pt) 2018-03-20
MX368941B (es) 2019-10-22
MX2015017525A (es) 2016-06-30

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]