MX2015017525A - Un procedimiento para preparar un producto de ácido hialurónico entrelazado. - Google Patents

Un procedimiento para preparar un producto de ácido hialurónico entrelazado.

Info

Publication number
MX2015017525A
MX2015017525A MX2015017525A MX2015017525A MX2015017525A MX 2015017525 A MX2015017525 A MX 2015017525A MX 2015017525 A MX2015017525 A MX 2015017525A MX 2015017525 A MX2015017525 A MX 2015017525A MX 2015017525 A MX2015017525 A MX 2015017525A
Authority
MX
Mexico
Prior art keywords
cross
activated
linking
hyaluronic acid
preparing
Prior art date
Application number
MX2015017525A
Other languages
English (en)
Other versions
MX368941B (es
Inventor
Katarina Edsman
Morgan Karlsson
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa filed Critical Galderma Sa
Publication of MX2015017525A publication Critical patent/MX2015017525A/es
Publication of MX368941B publication Critical patent/MX368941B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/244—Stepwise homogeneous crosslinking of one polymer with one crosslinking system, e.g. partial curing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

Se proporciona un entrelazado eficiente del ácido hialurónico (HA) mediante un procedimiento de fabricación; en el procedimiento, el HA es activado por un entrelazado inicial en una solución acuosa; el agente de entrelazado sin reaccionar se elimina del HA activado; el entrelazado del HA activado es finalizado, sin adición de ningún agente adicional de entrelazado, en una suspensión de un medio líquido precipitante y el HA activado en forma precipitada; los productos resultantes de HA entrelazado exhiben una alta proporción de entrelazador efectivo y otras propiedades favorables, haciendo los productos útiles como implantes y en cirugía médica y cosmética.
MX2015017525A 2013-06-28 2014-06-05 Un procedimiento para preparar un producto de ácido hialurónico entrelazado. MX368941B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2013063718 2013-06-28
PCT/EP2014/061674 WO2014206701A1 (en) 2013-06-28 2014-06-05 A process for preparing a cross-linked hyaluronic acid product

Publications (2)

Publication Number Publication Date
MX2015017525A true MX2015017525A (es) 2016-06-30
MX368941B MX368941B (es) 2019-10-22

Family

ID=48703546

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017525A MX368941B (es) 2013-06-28 2014-06-05 Un procedimiento para preparar un producto de ácido hialurónico entrelazado.

Country Status (11)

Country Link
US (2) US10077320B2 (es)
JP (1) JP6479783B2 (es)
KR (1) KR20160025026A (es)
CN (2) CN110003360A (es)
AU (1) AU2014301493B2 (es)
BR (1) BR112015031457A2 (es)
CA (1) CA2916330A1 (es)
HK (1) HK1224315A1 (es)
MX (1) MX368941B (es)
RU (1) RU2689559C2 (es)
WO (1) WO2014206701A1 (es)

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FR3032617B1 (fr) * 2015-02-16 2018-03-16 Kylane Laboratoires Sa Procede de preparation d un hydrogel injectable; hydrogel obtenu; utilisation de l hydrogel obtenu
EP3328351A1 (en) * 2015-07-27 2018-06-06 Galderma S.A. A process for efficient cross-linking of hyaluronic acid
EP3162813A1 (en) * 2015-11-02 2017-05-03 Merz Pharma GmbH & Co. KGaA Process for depleting epoxide species in crosslinked poly-saccharide gel compositions and compositions obtained thereby
KR20170090965A (ko) * 2016-01-29 2017-08-08 한미약품 주식회사 복합 히알루론산 가교물 및 그 제조방법
WO2017131298A1 (en) * 2016-01-29 2017-08-03 Hanmi Pharm. Co., Ltd. Combination of cross-linked hyaluronic acids and method of preparing the same
CN111263646A (zh) 2017-06-26 2020-06-09 自然进化公司 基于丝-透明质酸的组织填充物及其使用方法
CN108395552B (zh) * 2017-12-15 2021-03-19 浙江景嘉医疗科技有限公司 一种单相交联透明质酸钠凝胶的制备方法
WO2020116999A1 (ko) * 2018-12-07 2020-06-11 한미약품 주식회사 히알루론산 가교물, 히알루론산 수화 겔 및 이들의 제조방법
CN113166434B (zh) * 2018-12-07 2024-07-09 韩美药品株式会社 交联透明质酸、透明质酸水凝胶及其制备方法
ES2969884T3 (es) * 2019-04-02 2024-05-23 Volumina Medical Sa Composición que comprende un poliol reticulado
USD918654S1 (en) 2019-06-06 2021-05-11 Sharkninja Operating Llc Grill plate
CN112147029A (zh) * 2019-06-28 2020-12-29 杭州协合医疗用品有限公司 一种交联透明质酸钠凝胶溶胀度的测定方法
JP2022543137A (ja) * 2019-09-27 2022-10-07 エルジー・ケム・リミテッド 高分子マイクロ粒子の製造方法、高分子マイクロ粒子、それを含む医療用組成物、美容組成物、医療用品および美容用品
KR102425496B1 (ko) * 2020-05-08 2022-07-26 주식회사 종근당 고탄성, 고점도 및 고유효 가교율을 갖는 히알루론산 가교체, 및 이의 제조방법
KR102527095B1 (ko) 2020-12-18 2023-04-28 충남대학교산학협력단 가교 처리된 히알루론산 조성물의 가교율 측정방법
KR20230153377A (ko) * 2021-03-02 2023-11-06 시매테스 중합체를 기반으로 하는 이식가능한 또는 주입가능한 생성물 및 그의 제조 방법
CN113278170B (zh) * 2021-06-15 2021-11-16 苏州大学 一种化学交联透明质酸水凝胶及其制备方法与应用

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US4716224A (en) * 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
SE452469B (sv) * 1986-06-18 1987-11-30 Pharmacia Ab Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
SE8900422D0 (sv) * 1989-02-08 1989-02-08 Pharmacia Ab Tvaerbundna hyaluronatgeler samt foerfarande foer framstaellning av dessa
US5827937A (en) * 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
IT1303735B1 (it) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
FR2811996B1 (fr) * 2000-07-19 2003-08-08 Corneal Ind Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations
AU2003901834A0 (en) * 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
FR2865737B1 (fr) * 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible
WO2006030965A1 (en) * 2004-09-15 2006-03-23 Seikagaku Corporation Photoreactive polysaccharide, photocrosslinked polysaccharide products, the method of making them and medical materials therefrom
JP2006111867A (ja) * 2004-09-15 2006-04-27 Seikagaku Kogyo Co Ltd 光反応性多糖、その光架橋多糖生成物及び医用材料
WO2006051950A1 (ja) * 2004-11-15 2006-05-18 Shiseido Co., Ltd. 架橋ヒアルロン酸ゲルの製造方法
US20060105022A1 (en) 2004-11-15 2006-05-18 Shiseido Co., Ltd. Process for preparing crosslinked hyaluronic acid gel
ES2636998T3 (es) * 2004-11-24 2017-10-10 Albumedix A/S Método de reticulación de ácido hialurónico con divinil sulfona
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CN101153061A (zh) * 2006-09-29 2008-04-02 北京普麦迪克生物技术研究所 一种透明质酸及其二次交联形成凝胶的方法
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Also Published As

Publication number Publication date
MX368941B (es) 2019-10-22
AU2014301493A1 (en) 2016-02-11
KR20160025026A (ko) 2016-03-07
CN105473623A (zh) 2016-04-06
RU2689559C2 (ru) 2019-05-28
AU2014301493B2 (en) 2018-11-29
US10077320B2 (en) 2018-09-18
CA2916330A1 (en) 2014-12-31
CN105473623B (zh) 2019-10-29
WO2014206701A1 (en) 2014-12-31
CN110003360A (zh) 2019-07-12
RU2016101736A3 (es) 2018-03-20
BR112015031457A2 (pt) 2017-07-25
US20190062461A1 (en) 2019-02-28
JP6479783B2 (ja) 2019-03-06
HK1224315A1 (zh) 2017-08-18
JP2016523303A (ja) 2016-08-08
RU2016101736A (ru) 2017-08-02
US20160376382A1 (en) 2016-12-29

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