MX360833B - Formulacion acuosa esteril inyectable basada en acido hialuronico reticulado e hidroxiapatita para uso para estético. - Google Patents
Formulacion acuosa esteril inyectable basada en acido hialuronico reticulado e hidroxiapatita para uso para estético.Info
- Publication number
- MX360833B MX360833B MX2015004307A MX2015004307A MX360833B MX 360833 B MX360833 B MX 360833B MX 2015004307 A MX2015004307 A MX 2015004307A MX 2015004307 A MX2015004307 A MX 2015004307A MX 360833 B MX360833 B MX 360833B
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxyapatite
- hyaluronic acid
- sterile aqueous
- aqueous formulation
- crosslinked hyaluronic
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
- 239000013011 aqueous formulation Substances 0.000 title abstract 3
- 229920002674 hyaluronan Polymers 0.000 title abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 title abstract 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title abstract 3
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El objetivo de la presente invención es una formulación acuosa estéril inyectable, lista para utilizar, resorbible, utilizada para propósitos estéticos como un gel viscoelástico, cohesivo, particulado que comprende i) ácido hialurónico entrelazado, o una de sus sales, a una concentración de entre 1% y 4% (masa/volumen); el entrelazamiento efectuado brinda la posibilidad de obtener un gel basado en ácido hialurónico entrelazado que tiene una denominada estructura cohesiva, y ii) hidroxiapatita, a una concentración de entre 5% y 60% (masa/volumen), dicha hidroxiapatita está en forma de partículas con un tamaño promedio menor de o igual a 200 µm, dicha formulación acuosa estéril inyectable tiene propiedades viscoelásticas tales que tan d a la frecuencia de 1 Hz es menor de o igual a 0.60.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1259577 | 2012-10-08 | ||
| PCT/EP2013/069874 WO2014056722A2 (fr) | 2012-10-08 | 2013-09-24 | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage esthétique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015004307A MX2015004307A (es) | 2015-08-20 |
| MX360833B true MX360833B (es) | 2018-11-20 |
Family
ID=47295066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015004307A MX360833B (es) | 2012-10-08 | 2013-09-24 | Formulacion acuosa esteril inyectable basada en acido hialuronico reticulado e hidroxiapatita para uso para estético. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20150257989A1 (es) |
| EP (1) | EP2903589B1 (es) |
| JP (1) | JP6342906B2 (es) |
| KR (1) | KR101773989B1 (es) |
| CN (1) | CN104703582B (es) |
| AR (1) | AR092933A1 (es) |
| AU (1) | AU2013329751B2 (es) |
| BR (1) | BR112015007772B1 (es) |
| CA (1) | CA2887316C (es) |
| ES (1) | ES2668689T3 (es) |
| IL (1) | IL237848B (es) |
| IN (1) | IN2015DN02298A (es) |
| LT (1) | LT2903589T (es) |
| MX (1) | MX360833B (es) |
| PL (1) | PL2903589T3 (es) |
| RU (1) | RU2648450C2 (es) |
| SG (1) | SG11201502743PA (es) |
| TR (1) | TR201807119T4 (es) |
| TW (1) | TWI641393B (es) |
| WO (1) | WO2014056722A2 (es) |
| ZA (1) | ZA201501697B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10463762B2 (en) * | 2012-10-08 | 2019-11-05 | Anteis S.A. | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use |
| CN104853742B (zh) * | 2012-10-08 | 2018-11-30 | 爱普蒂森股份公司 | 用于治疗用途的基于交联透明质酸和羟基磷灰石的可注射无菌水性制剂 |
| TWI716365B (zh) * | 2014-11-13 | 2021-01-21 | 德商梅茲製藥有限兩合公司 | 注射型真皮填充劑組合物及其套組、製備方法、與使用 |
| FR3036035B1 (fr) * | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| KR20170060599A (ko) | 2015-11-24 | 2017-06-01 | (주)한국비엠아이 | 히알루론산 유도체 및 dna 분획물이 포함된 히알루론산 주사용 조성물 및 이의 이용 |
| FR3044557B1 (fr) * | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
| KR101886413B1 (ko) * | 2016-03-16 | 2018-08-10 | 주식회사 엘앤씨바이오 | 히알루론산에 기반한 연조직 충진 조성물의 제조 방법 |
| WO2018020501A1 (en) | 2016-07-27 | 2018-02-01 | Marbelle Threads Ltd. | Threads of cross-linked hyaluronic acid and hydroxyapatite |
| EP4233926A3 (en) * | 2016-09-07 | 2024-01-17 | Allergan Pharmaceuticals International Limited | Methods of manufacturing injectable gels comprising cross-linked hyaluronic acid and hydroxyapatite |
| IT201700008651A1 (it) * | 2017-01-26 | 2018-07-26 | Beauty System Pharma Ltd | Acido ialuronico reticolato con agenti reticolanti di tipo naturale o semisintetico |
| SG11201913229PA (en) | 2017-06-26 | 2020-01-30 | Evolved By Nature Inc | Silk-hyaluronic acid based tissue fillers and methods of using the same |
| CN107496990A (zh) * | 2017-08-15 | 2017-12-22 | 广东泰宝医疗器械技术研究院有限公司 | 一种可注射的抗菌软骨修复水凝胶及其制备方法 |
| CN110636870A (zh) | 2017-10-10 | 2019-12-31 | 依娜完美护肤解决方案有限公司 | 制备包含透明质酸和羟基磷灰石的真皮填充物组合物的方法以及包含透明质酸和羟基磷灰石的真皮填充物组合物 |
| WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
| US11672750B2 (en) | 2018-04-13 | 2023-06-13 | Merz Pharma Gmbh & Co. Kgaa | Dermal filler based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose, a process for preparing same and uses thereof |
| CN108744054A (zh) * | 2018-06-15 | 2018-11-06 | 北京水元生生物科技有限公司 | 一种注射型美容整形用面部填充剂组合物凝胶及其制备方法 |
| WO2020095079A1 (fr) * | 2018-11-06 | 2020-05-14 | Kylane Laboratoires Sa | Composition injectable contenant de l'acide hyaluronique pour des applications au niveau du corps |
| CN111166686A (zh) * | 2018-11-12 | 2020-05-19 | 无锡市伙伴日化科技有限公司 | 一种玻尿酸爽肤水 |
| WO2020132331A1 (en) | 2018-12-19 | 2020-06-25 | Evolved By Nature, Inc. | Silk-hyaluronic acid tissue fillers and methods of making and using the same |
| EP4099978A1 (en) * | 2020-02-06 | 2022-12-14 | Merz Pharma GmbH & Co. KGaA | Injectable composition for skin and soft tissue augmentation |
| KR102686600B1 (ko) * | 2021-08-05 | 2024-07-19 | 주식회사 바이오비쥬 | 가교 히알루론산을 포함하는 화장료 조성물 및 이의 제조방법 |
| US20250114281A1 (en) * | 2022-01-18 | 2025-04-10 | Korea Institute Of Science And Technology | Apatite for filler and filler composition comprising same |
| ES2947097A1 (es) * | 2022-02-01 | 2023-08-01 | Martinez Miguel Angel Gomariz | Metodo cosmetico de rejuvenecimiento de la piel |
| CN115137877A (zh) * | 2022-03-25 | 2022-10-04 | 杭州诺嫣生物科技有限公司 | 注射型凝胶组合物及其制备方法和应用 |
| CN116570765A (zh) * | 2023-06-02 | 2023-08-11 | 河北优固生物科技有限公司 | 一种人体软组织填充材料及其制备方法 |
| WO2025160811A1 (zh) * | 2024-01-31 | 2025-08-07 | 上海睿星医疗器材有限公司 | 用于真皮填充的均质凝胶组合物及其制法和应用 |
| CN118206089B (zh) * | 2024-03-20 | 2024-11-26 | 上海倍尔康生物医学科技有限公司 | 一种羟基磷灰石微球及其制备方法和应用 |
| CN119367616A (zh) * | 2024-10-29 | 2025-01-28 | 德清奥维泰生物科技有限公司 | 一种交联透明质酸钠凝胶含多孔羟基磷灰石微球复合物及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6537574B1 (en) * | 1992-02-11 | 2003-03-25 | Bioform, Inc. | Soft tissue augmentation material |
| ATE269371T1 (de) | 1992-02-28 | 2004-07-15 | Cohesion Tech Inc | Injektierbare, keramische verbindungen sowie verfahren zu deren herstellung und anwendung |
| US7842300B2 (en) * | 2002-07-31 | 2010-11-30 | Dentsply International, Inc. | Bone repair putty |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| US20100004700A1 (en) | 2008-03-05 | 2010-01-07 | Neville Alleyne | Method of treating tissue with a suspenson of tricalcium hydroxyapatite microspheres |
| CN101596328A (zh) | 2008-06-02 | 2009-12-09 | 山东省生物药物研究院 | 一种复合生物材料及其制备方法和应用 |
| FR2938187B1 (fr) * | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
| FR2945949B1 (fr) * | 2009-05-26 | 2011-05-13 | Anteis Sa | Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme. |
| CA2780274C (en) | 2009-11-09 | 2018-06-26 | Spotlight Technology Partners Llc | Fragmented hydrogels |
| US8915043B2 (en) * | 2011-05-25 | 2014-12-23 | General Electric Company | Bolt connection for a wind tower lattice structure |
| ITAN20110138A1 (it) * | 2011-10-12 | 2012-01-11 | Regenyal Lab S R L | Sintesi di un gel iniettabile multifasico a base di acido ialuronico monofasico libero e reticolato e di acido ialuronico bifasico associato con idrossiapatite con inibitore della ialuronidasi microincapsulato. |
| CN104853742B (zh) | 2012-10-08 | 2018-11-30 | 爱普蒂森股份公司 | 用于治疗用途的基于交联透明质酸和羟基磷灰石的可注射无菌水性制剂 |
-
2013
- 2013-09-24 EP EP13766322.5A patent/EP2903589B1/fr active Active
- 2013-09-24 KR KR1020157009968A patent/KR101773989B1/ko active Active
- 2013-09-24 JP JP2015536048A patent/JP6342906B2/ja active Active
- 2013-09-24 CN CN201380052596.3A patent/CN104703582B/zh active Active
- 2013-09-24 US US14/433,927 patent/US20150257989A1/en not_active Abandoned
- 2013-09-24 BR BR112015007772A patent/BR112015007772B1/pt active IP Right Grant
- 2013-09-24 LT LTEP13766322.5T patent/LT2903589T/lt unknown
- 2013-09-24 WO PCT/EP2013/069874 patent/WO2014056722A2/fr not_active Ceased
- 2013-09-24 AU AU2013329751A patent/AU2013329751B2/en active Active
- 2013-09-24 RU RU2015115974A patent/RU2648450C2/ru active
- 2013-09-24 ES ES13766322.5T patent/ES2668689T3/es active Active
- 2013-09-24 SG SG11201502743PA patent/SG11201502743PA/en unknown
- 2013-09-24 PL PL13766322T patent/PL2903589T3/pl unknown
- 2013-09-24 CA CA2887316A patent/CA2887316C/en active Active
- 2013-09-24 MX MX2015004307A patent/MX360833B/es active IP Right Grant
- 2013-09-24 TR TR2018/07119T patent/TR201807119T4/tr unknown
- 2013-10-08 AR ARP130103635A patent/AR092933A1/es active IP Right Grant
- 2013-10-08 TW TW102136381A patent/TWI641393B/zh active
-
2015
- 2015-03-12 ZA ZA2015/01697A patent/ZA201501697B/en unknown
- 2015-03-19 IL IL237848A patent/IL237848B/en active IP Right Grant
- 2015-03-20 IN IN2298DEN2015 patent/IN2015DN02298A/en unknown
-
2018
- 2018-03-06 US US15/913,086 patent/US10493006B2/en active Active
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