BR112015007772A2 - formulação aquosa estéril injetável, kit e método de fabricação da mesma - Google Patents
formulação aquosa estéril injetável, kit e método de fabricação da mesmaInfo
- Publication number
- BR112015007772A2 BR112015007772A2 BR112015007772A BR112015007772A BR112015007772A2 BR 112015007772 A2 BR112015007772 A2 BR 112015007772A2 BR 112015007772 A BR112015007772 A BR 112015007772A BR 112015007772 A BR112015007772 A BR 112015007772A BR 112015007772 A2 BR112015007772 A2 BR 112015007772A2
- Authority
- BR
- Brazil
- Prior art keywords
- aqueous formulation
- kit
- cross
- manufacture
- sterile aqueous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
resumo formulação aquosa estéril injetável, kit e método de fabricação da mesma a presente invenção refere-se a uma formulação aquosa estéril injetável, pronta para uso, reabsorvível, utilizada para fins cosméticos, na forma de gel viscoelástico coesivo particulado compreendendo i) ácido hialurônico reticulado ou um de seus sais, a uma concentração entre 1% e 4% (massa/volume); a reticulação efetuada permitindo-se obter um gel à base de ácido hialurônico reticulado de estrutura dita coesiva, e ii) hidroxiapatita, a uma concentração de entre 5% a 60% (massa/volume), a referida hidroxiapatita estando sob a forma de partículas de tamanho médio menor que ou igual a 200 µm; a referida formulação aquosa estéril injetável tendo propriedades viscoelásticas tais que tand à frequência de 1 hz é inferior ou igual a 0,60.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1259577 | 2012-10-08 | ||
PCT/EP2013/069874 WO2014056722A2 (fr) | 2012-10-08 | 2013-09-24 | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage esthétique |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015007772A2 true BR112015007772A2 (pt) | 2017-07-04 |
BR112015007772B1 BR112015007772B1 (pt) | 2020-05-05 |
Family
ID=47295066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015007772A BR112015007772B1 (pt) | 2012-10-08 | 2013-09-24 | formulação aquosa estéril injetável contendo ácido hialurônico reticulado e de hidroxiapatita para uso estético |
Country Status (22)
Country | Link |
---|---|
US (2) | US20150257989A1 (pt) |
EP (1) | EP2903589B1 (pt) |
JP (1) | JP6342906B2 (pt) |
KR (1) | KR101773989B1 (pt) |
CN (1) | CN104703582B (pt) |
AR (1) | AR092933A1 (pt) |
AU (1) | AU2013329751B2 (pt) |
BR (1) | BR112015007772B1 (pt) |
CA (1) | CA2887316C (pt) |
ES (1) | ES2668689T3 (pt) |
HK (1) | HK1210429A1 (pt) |
IL (1) | IL237848B (pt) |
IN (1) | IN2015DN02298A (pt) |
LT (1) | LT2903589T (pt) |
MX (1) | MX360833B (pt) |
PL (1) | PL2903589T3 (pt) |
RU (1) | RU2648450C2 (pt) |
SG (1) | SG11201502743PA (pt) |
TR (1) | TR201807119T4 (pt) |
TW (1) | TWI641393B (pt) |
WO (1) | WO2014056722A2 (pt) |
ZA (1) | ZA201501697B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2903591B1 (fr) * | 2012-10-08 | 2016-07-06 | Aptissen S.A. | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage thérapeutique |
US10463762B2 (en) * | 2012-10-08 | 2019-11-05 | Anteis S.A. | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use |
TWI716365B (zh) * | 2014-11-13 | 2021-01-21 | 德商梅茲製藥有限兩合公司 | 注射型真皮填充劑組合物及其套組、製備方法、與使用 |
FR3036035B1 (fr) * | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
RU2697671C1 (ru) | 2015-11-24 | 2019-08-16 | БиЭмАй КОРЕЯ КО., ЛТД | Композиция для инъекций гиалуроновой кислоты, содержащей производное гиалуроновой кислоты и ДНК фракцию, и ее применение |
FR3044557B1 (fr) * | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
KR101886413B1 (ko) * | 2016-03-16 | 2018-08-10 | 주식회사 엘앤씨바이오 | 히알루론산에 기반한 연조직 충진 조성물의 제조 방법 |
CA3032063A1 (en) | 2016-07-27 | 2018-02-01 | Marbelle Threads Ltd. | Threads of cross-linked hyaluronic acid and hydroxyapatite |
WO2018047182A1 (en) * | 2016-09-07 | 2018-03-15 | Luminera Derm Ltd. | Injectable gels comprising cross-linked hyaluronic acid and hydroxyapatite, and methods of manufacturing thereof |
IT201700008651A1 (it) * | 2017-01-26 | 2018-07-26 | Beauty System Pharma Ltd | Acido ialuronico reticolato con agenti reticolanti di tipo naturale o semisintetico |
CN107496990A (zh) * | 2017-08-15 | 2017-12-22 | 广东泰宝医疗器械技术研究院有限公司 | 一种可注射的抗菌软骨修复水凝胶及其制备方法 |
CA3052929A1 (en) * | 2017-10-10 | 2019-04-18 | E.N.A. Impeccable Skincare Solutions Ltd | Method of manufacturing and dermal filler compositions containing hyaluronic acid and hydroxyapatite |
WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
ES2912967T3 (es) | 2018-04-13 | 2022-05-30 | Merz Pharma Gmbh & Co Kgaa | Relleno dérmico a base de ácido hialurónico reticulado, partículas de material de fosfato de calcio y carboximetilcelulosa, un proceso para prepararlo y sus usos |
CN108744054A (zh) * | 2018-06-15 | 2018-11-06 | 北京水元生生物科技有限公司 | 一种注射型美容整形用面部填充剂组合物凝胶及其制备方法 |
WO2020095079A1 (fr) * | 2018-11-06 | 2020-05-14 | Kylane Laboratoires Sa | Composition injectable contenant de l'acide hyaluronique pour des applications au niveau du corps |
CN111166686A (zh) * | 2018-11-12 | 2020-05-19 | 无锡市伙伴日化科技有限公司 | 一种玻尿酸爽肤水 |
US20230108822A1 (en) * | 2020-02-06 | 2023-04-06 | Merz Pharma Gmbh & Co. Kgaa | Injectable composition for skin and soft tissue augmentation |
ES2947097A1 (es) * | 2022-02-01 | 2023-08-01 | Martinez Miguel Angel Gomariz | Metodo cosmetico de rejuvenecimiento de la piel |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6537574B1 (en) * | 1992-02-11 | 2003-03-25 | Bioform, Inc. | Soft tissue augmentation material |
AU666712B2 (en) | 1992-02-28 | 1996-02-22 | Cohesion Technologies, Inc. | Injectable ceramic compositions and methods for their preparation and use |
WO2004011053A1 (en) * | 2002-07-31 | 2004-02-05 | Dentsply International Inc. | Bone repair putty comprising porous particulate and carrier gel |
FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
US20100004700A1 (en) | 2008-03-05 | 2010-01-07 | Neville Alleyne | Method of treating tissue with a suspenson of tricalcium hydroxyapatite microspheres |
CN101596328A (zh) | 2008-06-02 | 2009-12-09 | 山东省生物药物研究院 | 一种复合生物材料及其制备方法和应用 |
FR2938187B1 (fr) * | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
FR2945949B1 (fr) * | 2009-05-26 | 2011-05-13 | Anteis Sa | Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme. |
NZ599527A (en) | 2009-11-09 | 2014-04-30 | Spotlight Technology Partners Llc | Fragmented hydrogels |
US8915043B2 (en) * | 2011-05-25 | 2014-12-23 | General Electric Company | Bolt connection for a wind tower lattice structure |
ITAN20110138A1 (it) * | 2011-10-12 | 2012-01-11 | Regenyal Lab S R L | Sintesi di un gel iniettabile multifasico a base di acido ialuronico monofasico libero e reticolato e di acido ialuronico bifasico associato con idrossiapatite con inibitore della ialuronidasi microincapsulato. |
EP2903591B1 (fr) | 2012-10-08 | 2016-07-06 | Aptissen S.A. | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage thérapeutique |
-
2013
- 2013-09-24 EP EP13766322.5A patent/EP2903589B1/fr active Active
- 2013-09-24 SG SG11201502743PA patent/SG11201502743PA/en unknown
- 2013-09-24 LT LTEP13766322.5T patent/LT2903589T/lt unknown
- 2013-09-24 US US14/433,927 patent/US20150257989A1/en not_active Abandoned
- 2013-09-24 TR TR2018/07119T patent/TR201807119T4/tr unknown
- 2013-09-24 JP JP2015536048A patent/JP6342906B2/ja active Active
- 2013-09-24 RU RU2015115974A patent/RU2648450C2/ru active
- 2013-09-24 PL PL13766322T patent/PL2903589T3/pl unknown
- 2013-09-24 AU AU2013329751A patent/AU2013329751B2/en active Active
- 2013-09-24 MX MX2015004307A patent/MX360833B/es active IP Right Grant
- 2013-09-24 WO PCT/EP2013/069874 patent/WO2014056722A2/fr active Application Filing
- 2013-09-24 CN CN201380052596.3A patent/CN104703582B/zh active Active
- 2013-09-24 ES ES13766322.5T patent/ES2668689T3/es active Active
- 2013-09-24 KR KR1020157009968A patent/KR101773989B1/ko active IP Right Grant
- 2013-09-24 BR BR112015007772A patent/BR112015007772B1/pt active IP Right Grant
- 2013-09-24 CA CA2887316A patent/CA2887316C/en active Active
- 2013-10-08 AR ARP130103635A patent/AR092933A1/es active IP Right Grant
- 2013-10-08 TW TW102136381A patent/TWI641393B/zh active
-
2015
- 2015-03-12 ZA ZA2015/01697A patent/ZA201501697B/en unknown
- 2015-03-19 IL IL237848A patent/IL237848B/en active IP Right Grant
- 2015-03-20 IN IN2298DEN2015 patent/IN2015DN02298A/en unknown
- 2015-11-16 HK HK15111274.7A patent/HK1210429A1/xx unknown
-
2018
- 2018-03-06 US US15/913,086 patent/US10493006B2/en active Active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/09/2013, OBSERVADAS AS CONDICOES LEGAIS. |