BR112017010074A2 - preenchimento dérmico a base de ácido hialurônico reticulado e lubrificante de carboximetilcelulose - Google Patents
preenchimento dérmico a base de ácido hialurônico reticulado e lubrificante de carboximetilceluloseInfo
- Publication number
- BR112017010074A2 BR112017010074A2 BR112017010074-6A BR112017010074A BR112017010074A2 BR 112017010074 A2 BR112017010074 A2 BR 112017010074A2 BR 112017010074 A BR112017010074 A BR 112017010074A BR 112017010074 A2 BR112017010074 A2 BR 112017010074A2
- Authority
- BR
- Brazil
- Prior art keywords
- dermal filler
- carboxymethylcellulose
- hyaluronic acid
- lubricant
- cross
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Composite Materials (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
a presente invenção refere-se a composições injetáveis para preenchimento dérmico sob a forma de um gel, compreendendo ácido hialurônico (ha), carboximetilcelulose (cmc), e, opcionalmente, micropartículas, como micropartículas de hidroxiapatita cálcica (cahap). as composições injetáveis para preenchimento dérmico tem propriedades reológicas aprimoradas e, ao mesmo tempo, tem forças de extrusão baixas. a presente invenção refere¬-se, ainda, a um método para preparação dessas composições injetáveis para preenchimento dérmico e seus usos para fins terapêuticos e cosméticos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14003829 | 2014-11-13 | ||
EP14003829.0 | 2014-11-13 | ||
EP15000338.2 | 2015-02-05 | ||
EP15000338 | 2015-02-05 | ||
PCT/EP2015/002270 WO2016074794A1 (en) | 2014-11-13 | 2015-11-12 | Dermal filler based on crosslinked hyaluronic acid and carboxymethyl cellulose lubricant |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017010074A2 true BR112017010074A2 (pt) | 2018-01-02 |
BR112017010074B1 BR112017010074B1 (pt) | 2021-05-04 |
Family
ID=54695656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017010074-6A BR112017010074B1 (pt) | 2014-11-13 | 2015-11-12 | preenchimento dérmico a base de ácido hialurônico reticulado e lubrificante de carboximetilcelulose, método de preparação e seus usos |
Country Status (18)
Country | Link |
---|---|
US (1) | US10335512B2 (pt) |
EP (1) | EP3218023B1 (pt) |
JP (1) | JP6721584B2 (pt) |
KR (1) | KR102483607B1 (pt) |
CN (1) | CN106999625B (pt) |
AU (1) | AU2015345523B2 (pt) |
BR (1) | BR112017010074B1 (pt) |
CA (1) | CA2967699C (pt) |
ES (1) | ES2688731T3 (pt) |
IL (1) | IL252265B (pt) |
LT (1) | LT3218023T (pt) |
MX (1) | MX2017006232A (pt) |
PL (1) | PL3218023T3 (pt) |
RU (1) | RU2712641C2 (pt) |
SG (1) | SG11201703952QA (pt) |
TW (1) | TWI716365B (pt) |
WO (1) | WO2016074794A1 (pt) |
ZA (1) | ZA201703351B (pt) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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CA3032063A1 (en) * | 2016-07-27 | 2018-02-01 | Marbelle Threads Ltd. | Threads of cross-linked hyaluronic acid and hydroxyapatite |
BR112019004332B1 (pt) | 2016-09-07 | 2022-09-06 | Luminera Derm Ltd | Géis injetáveis que compreendem ácido hialurônico reticulado e hidroxiapatita, composição e processo de fabricação dos mesmos |
EP3295968A1 (en) * | 2016-09-16 | 2018-03-21 | Euroresearch S.r.l. | Combination of collagen and carboxymethyl cellulose and use thereof as a dermal filler |
CA3038981A1 (en) * | 2016-10-13 | 2018-04-19 | Allergan, Inc. | Coacervate hyaluronan hydrogels for dermal filler applications |
CN106421897B (zh) * | 2016-10-26 | 2022-04-19 | 曹京敏 | 人体软组织填充剂及其制备方法和专用粉碎机 |
TWI727174B (zh) | 2017-05-30 | 2021-05-11 | 荷蘭商阿克法Ip有限公司 | 新穎的再吸收性生物可降解醫藥及化粧品組合物 |
WO2019008210A2 (es) * | 2017-07-04 | 2019-01-10 | Universidad De Granada | Micropartículas que comprenden una composición para la resección endoscópica |
UA125589U (uk) * | 2018-01-03 | 2018-05-10 | Світлана Олександрівна Ларкіна | Композиція для естетичних ін'єкцій |
KR102444452B1 (ko) * | 2018-01-09 | 2022-09-19 | 주식회사 유영제약 | 온도 감응성 고분자 조성물 |
WO2019152964A1 (en) * | 2018-02-05 | 2019-08-08 | Henry Ford Health System | Compositions and methods for the removal of extraneous calcium hydroxyapatite |
WO2019197608A1 (en) | 2018-04-13 | 2019-10-17 | Merz Pharma Gmbh & Co. Kgaa | Dermal filler based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose, a process for preparing same and uses thereof |
WO2020002597A1 (en) * | 2018-06-29 | 2020-01-02 | Merz Pharma Gmbh & Co. Kgaa | Fatty acid-grafted hyaluronic acid, dermal filler formulations comprising same, process for preparation and use thereof |
US20210268143A1 (en) * | 2018-07-06 | 2021-09-02 | Lg Chem, Ltd. | Hyaluronic acid filler having high viscoelasticity and high cohesiveness |
BR112021000361B1 (pt) * | 2018-07-10 | 2023-12-05 | Lg Chem, Ltd | Enchimentos de hidrogel de ácido hialurônico com alta capacidade de levantamento e baixa força de injeção, método para preparação dos mesmos, seringa pré enchida, biomaterial para aumentar o tecido mole e usos dos ditos enchimentos para aumentar o tecido mole e melhorar as rugas |
US20220040383A1 (en) * | 2018-12-20 | 2022-02-10 | Lg Chem, Ltd. | Filler having excellent filler properties comprising hyaluronic acid hydrogel |
KR102344588B1 (ko) | 2019-06-25 | 2021-12-30 | 네이처코스텍 주식회사 | 변성 셀룰로오스를 포함하는 피부필러용 조성물 |
WO2020262727A1 (ko) | 2019-06-26 | 2020-12-30 | 네이처코스텍 주식회사 | 변성 셀룰로오스를 포함하는 피부필러용 조성물 |
KR102183941B1 (ko) | 2019-11-22 | 2020-11-27 | 주식회사 지씨에스 | 폴리-l-락틱산 필러와 히알루론산 필러 결합체를 함유하는 주사제제 및 그 제조방법 |
KR102391943B1 (ko) | 2019-11-26 | 2022-04-29 | 네이처코스텍 주식회사 | 변성 셀룰로오스와 히알루론산 함유 피부필러용 조성물 |
CN111249189B (zh) * | 2020-01-15 | 2021-07-23 | 陈勇 | 一种注射型美容整形用面部填充剂组合物及其制备方法 |
WO2021156345A1 (en) * | 2020-02-06 | 2021-08-12 | Merz Pharma Gmbh & Co. Kgaa | Injectable composition for skin and soft tissue augmentation |
FR3109153B1 (fr) * | 2020-04-10 | 2022-07-15 | Teoxane SA | Compositions à base d’au moins deux glycosaminoglycanes |
TWI731660B (zh) * | 2020-04-24 | 2021-06-21 | 透策生技股份有限公司 | 利用加壓手段以加速注射式填充物分散的處理方法 |
EP4199980A1 (en) * | 2020-08-18 | 2023-06-28 | Innate S.r.l. | Injectable composition and use of said composition |
KR102598899B1 (ko) * | 2021-05-13 | 2023-11-07 | 주식회사 바이오스탠다드 | 히알루론산 기반 기능성 하이드로겔 복합체 및 이의 제조방법 |
CN115382011A (zh) * | 2021-07-01 | 2022-11-25 | 意瑞生物科技(苏州)有限公司 | 一种皮肤注射填充剂凝胶及其制备工艺 |
CN113521388A (zh) * | 2021-07-30 | 2021-10-22 | 张广利 | 一种注射型美容整形用面部填充剂组合物及其制备方法 |
CN113559322A (zh) * | 2021-07-30 | 2021-10-29 | 张广利 | 一种美容整形用面部注射填充剂及其制备方法 |
CN113730650B (zh) * | 2021-10-13 | 2022-11-01 | 哈尔滨泽润医疗机构管理有限公司 | 一种碳水溶酶组合物及其制备方法和应用 |
CN114177352B (zh) * | 2021-12-22 | 2023-01-10 | 西安德诺海思医疗科技有限公司 | 一种梯度降解皮肤填充剂及其制备方法 |
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CN114146020B (zh) * | 2022-02-10 | 2022-04-29 | 中国远大集团有限责任公司 | 一种注射美容产品及其制备方法和应用 |
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CN114668890A (zh) * | 2022-03-28 | 2022-06-28 | 常州药物研究所有限公司 | 注射用含碳酸钙微球的混合凝胶及其制备方法 |
KR102495269B1 (ko) | 2022-04-06 | 2023-02-06 | 이해경 | 가교 히알루론산 함유 피부 필러 조성물 및 그 제조방법 |
CN115337461B (zh) * | 2022-08-16 | 2024-04-16 | 常州药物研究所有限公司 | 注射用含大粒径碳酸钙颗粒的复合凝胶及其制备方法 |
KR102643334B1 (ko) | 2022-08-23 | 2024-03-05 | 주식회사 큐에이치바이오 | 가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법 |
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KR102649054B1 (ko) | 2023-04-20 | 2024-03-19 | 주식회사 큐에이치바이오 | Ech-가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법 |
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- 2015-11-12 MX MX2017006232A patent/MX2017006232A/es active IP Right Grant
- 2015-11-12 US US15/526,460 patent/US10335512B2/en active Active
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CA2967699C (en) | 2023-07-04 |
ES2688731T3 (es) | 2018-11-06 |
MX2017006232A (es) | 2018-01-23 |
AU2015345523B2 (en) | 2019-05-16 |
IL252265A0 (en) | 2017-07-31 |
RU2017119805A3 (pt) | 2019-06-14 |
TWI716365B (zh) | 2021-01-21 |
PL3218023T3 (pl) | 2019-03-29 |
RU2017119805A (ru) | 2018-12-14 |
SG11201703952QA (en) | 2017-06-29 |
WO2016074794A1 (en) | 2016-05-19 |
CA2967699A1 (en) | 2016-05-19 |
BR112017010074B1 (pt) | 2021-05-04 |
CN106999625A (zh) | 2017-08-01 |
KR102483607B1 (ko) | 2022-12-30 |
ZA201703351B (en) | 2019-01-30 |
TW201625276A (zh) | 2016-07-16 |
LT3218023T (lt) | 2018-10-25 |
JP6721584B2 (ja) | 2020-07-15 |
CN106999625B (zh) | 2020-06-16 |
US20170333596A1 (en) | 2017-11-23 |
EP3218023B1 (en) | 2018-09-05 |
EP3218023A1 (en) | 2017-09-20 |
JP2017533785A (ja) | 2017-11-16 |
US10335512B2 (en) | 2019-07-02 |
KR20170117368A (ko) | 2017-10-23 |
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