MX368970B - Formulacion de factor de crecimiento de fibroblastos 18 en hidrogeles de alginato/colageno. - Google Patents

Formulacion de factor de crecimiento de fibroblastos 18 en hidrogeles de alginato/colageno.

Info

Publication number
MX368970B
MX368970B MX2016008442A MX2016008442A MX368970B MX 368970 B MX368970 B MX 368970B MX 2016008442 A MX2016008442 A MX 2016008442A MX 2016008442 A MX2016008442 A MX 2016008442A MX 368970 B MX368970 B MX 368970B
Authority
MX
Mexico
Prior art keywords
fgf
hydrogels
alginate
formulation
collagen hydrogels
Prior art date
Application number
MX2016008442A
Other languages
English (en)
Other versions
MX2016008442A (es
Inventor
CANAL Fabiana
Lo Presti Caterina
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of MX2016008442A publication Critical patent/MX2016008442A/es
Publication of MX368970B publication Critical patent/MX368970B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers & Plastics (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención se refiere al campo de las formulaciones farmacéuticas; más en particular, está dirigida a hidrogeles homogéneos que comprenden un compuesto de factor de crecimiento de fibroblasto 18 (FGF-18) y a métodos de producción de dichos hidrogeles; los hidrogeles de la invención se pueden usar, una vez formados in situ, para el tratamiento de trastornos del cartílago como osteoartritis o lesión del cartílago.
MX2016008442A 2013-12-24 2014-12-23 Formulacion de factor de crecimiento de fibroblastos 18 en hidrogeles de alginato/colageno. MX368970B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13199591 2013-12-24
PCT/EP2014/079205 WO2015097236A2 (en) 2013-12-24 2014-12-23 Fgf-18 formulation in alginate/collagen hydrogels

Publications (2)

Publication Number Publication Date
MX2016008442A MX2016008442A (es) 2017-01-11
MX368970B true MX368970B (es) 2019-10-23

Family

ID=49882942

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016008442A MX368970B (es) 2013-12-24 2014-12-23 Formulacion de factor de crecimiento de fibroblastos 18 en hidrogeles de alginato/colageno.

Country Status (17)

Country Link
US (1) US9795714B2 (es)
EP (1) EP3086822B1 (es)
JP (1) JP6487448B2 (es)
KR (1) KR102434024B1 (es)
CN (1) CN106068131B (es)
AU (1) AU2014372578B2 (es)
BR (1) BR112016014717B1 (es)
CA (1) CA2934638C (es)
ES (1) ES2806026T3 (es)
HK (1) HK1225657A1 (es)
IL (1) IL246407B (es)
MX (1) MX368970B (es)
NZ (1) NZ721597A (es)
RU (1) RU2698210C2 (es)
SG (1) SG11201604972TA (es)
WO (1) WO2015097236A2 (es)
ZA (1) ZA201604610B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105103654B (zh) 2013-02-14 2017-06-23 纳米帕雷尔股份有限公司 纳米纤维混合毛毡
JP6791754B2 (ja) 2013-12-24 2020-11-25 アレス トレーディング ソシエテ アノニム キシログルカンゲル中のｆｇｆ−１８製剤
US10086112B2 (en) * 2014-02-20 2018-10-02 Merck Patent Gmbh Implant comprising FGF-18
US10408686B2 (en) * 2016-01-15 2019-09-10 Temptime Corporation Gel-based temperature indicators
EP3821920A4 (en) * 2018-07-13 2022-03-02 T-ACE Medical Co., Ltd. SUIT FOR ENDOSCOPIC SURGERY
CN112513245A (zh) * 2018-08-10 2021-03-16 持田制药株式会社 海藻酸中空微纤维
CN112969479A (zh) * 2018-11-06 2021-06-15 国立癌症中心 海藻酸基注射型凝胶体系
CN111068116B (zh) * 2019-12-28 2022-03-22 河北柯瑞生物医药有限公司 一种注射用软骨修复温敏凝胶及其制备方法
CN115605236B (zh) * 2020-05-14 2024-02-13 国家健康与医学研究院 用于软骨损伤的骨关节再生的复合产品
CN112263505A (zh) * 2020-10-29 2021-01-26 广州栋方生物科技股份有限公司 一种铜肽组合物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2254350A1 (en) * 1998-11-17 2000-05-17 Hsc Research And Development Limited Partnership Method for bioengineering cartilage
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US6355204B1 (en) * 2000-06-07 2002-03-12 Owens-Brockway Plastic Products Inc. Method of manufacturing a dual-chamber container
ES2523655T5 (es) * 2002-06-21 2018-04-23 Novo Nordisk Health Care Ag Composiciones sólidas estabilizadas de polipéptidos del Factor VIIa
CA2500742C (en) * 2002-10-07 2014-02-18 Zymogenetics, Inc. Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis
BRPI0515973B8 (pt) 2004-10-12 2021-07-27 Fmc Biopolymer As kit para produzir um gel de alginato, composição para preparar um gel e uso
US8741326B2 (en) * 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
MX2010011267A (es) * 2008-04-14 2010-12-21 Adocia Composicion osteogenica que comprende un complejo del factor de crecimiento/polimero anfifilico, una sal de cation soluble y un soporte organico.
JP2011160817A (ja) * 2010-02-04 2011-08-25 Univ Of Tokyo 移植支援材料
EP2628488B1 (en) * 2010-10-15 2020-04-08 Medical Research and Development Corporation Sustained-release pharmaceutical composition
US10034737B2 (en) * 2011-02-22 2018-07-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nano-reservoirs technology for use in bone and/or cartilage regeneration
TWI527590B (zh) * 2011-06-17 2016-04-01 艾瑞斯貿易公司 Ｆｇｆ－１８之凍乾調配物
JP6791754B2 (ja) 2013-12-24 2020-11-25 アレス トレーディング ソシエテ アノニム キシログルカンゲル中のｆｇｆ−１８製剤

Also Published As

Publication number Publication date
WO2015097236A2 (en) 2015-07-02
NZ721597A (en) 2022-07-01
AU2014372578A2 (en) 2016-11-17
JP2017502042A (ja) 2017-01-19
SG11201604972TA (en) 2016-07-28
BR112016014717A2 (pt) 2017-09-19
CA2934638A1 (en) 2015-07-02
RU2016129817A (ru) 2018-01-30
EP3086822B1 (en) 2020-04-15
CN106068131A (zh) 2016-11-02
US9795714B2 (en) 2017-10-24
HK1225657A1 (zh) 2017-09-15
IL246407A0 (en) 2016-08-31
RU2016129817A3 (es) 2018-08-24
KR102434024B1 (ko) 2022-08-22
IL246407B (en) 2020-01-30
ZA201604610B (en) 2018-11-28
CN106068131B (zh) 2020-01-17
EP3086822A2 (en) 2016-11-02
ES2806026T3 (es) 2021-02-16
AU2014372578A1 (en) 2016-07-14
AU2014372578B2 (en) 2018-03-01
RU2698210C2 (ru) 2019-08-23
JP6487448B2 (ja) 2019-03-20
BR112016014717B1 (pt) 2020-12-01
CA2934638C (en) 2022-07-12
MX2016008442A (es) 2017-01-11
KR20160101163A (ko) 2016-08-24
US20160303291A1 (en) 2016-10-20
WO2015097236A3 (en) 2015-09-17

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