CL2015002599A1 - Composiciones y métodos para la orientación de n-acetilglucosamina transferasa unida al oxigeno y promover sanamiento de heridas - Google Patents

Composiciones y métodos para la orientación de n-acetilglucosamina transferasa unida al oxigeno y promover sanamiento de heridas

Info

Publication number
CL2015002599A1
CL2015002599A1 CL2015002599A CL2015002599A CL2015002599A1 CL 2015002599 A1 CL2015002599 A1 CL 2015002599A1 CL 2015002599 A CL2015002599 A CL 2015002599A CL 2015002599 A CL2015002599 A CL 2015002599A CL 2015002599 A1 CL2015002599 A1 CL 2015002599A1
Authority
CL
Chile
Prior art keywords
linked
compositions
methods
wound healing
promoting wound
Prior art date
Application number
CL2015002599A
Other languages
English (en)
Inventor
David Rubenstein
Kasper Runager
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of CL2015002599A1 publication Critical patent/CL2015002599A1/es

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01186Glycogenin glucosyltransferase (2.4.1.186)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01255Protein O-GlcNAc transferase (2.4.1.255)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Power Engineering (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
CL2015002599A 2013-03-11 2015-09-11 Composiciones y métodos para la orientación de n-acetilglucosamina transferasa unida al oxigeno y promover sanamiento de heridas CL2015002599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361775937P 2013-03-11 2013-03-11

Publications (1)

Publication Number Publication Date
CL2015002599A1 true CL2015002599A1 (es) 2016-08-26

Family

ID=51658978

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002599A CL2015002599A1 (es) 2013-03-11 2015-09-11 Composiciones y métodos para la orientación de n-acetilglucosamina transferasa unida al oxigeno y promover sanamiento de heridas

Country Status (13)

Country Link
US (1) US20170166897A1 (es)
EP (1) EP2970978A4 (es)
JP (1) JP2016513968A (es)
KR (1) KR20150126048A (es)
CN (1) CN105408480A (es)
AU (1) AU2014248966A1 (es)
BR (1) BR112015022701A2 (es)
CA (1) CA2905337A1 (es)
CL (1) CL2015002599A1 (es)
MX (1) MX2015012124A (es)
RU (1) RU2015138544A (es)
SG (1) SG11201507211YA (es)
WO (1) WO2014164805A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020117937A1 (en) * 2018-12-06 2020-06-11 Bio Capital Holdings, LLC Glucose sensors and methods of use thereof
CN111234022B (zh) * 2019-12-16 2024-03-22 江苏省药物研究所有限公司 抗n-乙酰氨基葡萄糖转移酶修饰的蛋白质单克隆抗体及杂交瘤细胞株和其制备方法与应用
CN112707955B (zh) * 2020-12-21 2022-01-18 山东润德生物科技有限公司 提高N-乙酰氨基葡萄糖产量的RamAM转录因子突变体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108367A0 (en) * 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
WO1998044123A2 (en) * 1997-03-31 1998-10-08 The Government Of The United States Of America Represented By The Secretary Of The Department Of Health And Human Services O-LINKED GlcNAc TRANSFERASE (OGT): CLONING, MOLECULAR EXPRESSION, AND METHODS OF USE
CA2333901A1 (en) * 1998-08-03 2000-02-24 East Carolina University Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
AU776512B2 (en) * 1999-01-27 2004-09-09 David Laurence Becker Formulations comprising antisense nucleotides to connexins
CN101356437B (zh) * 2005-12-22 2012-08-01 J-油坊株式会社 具有由GnT-V转移的GlcNAc的糖链的检测方法
WO2010042228A2 (en) * 2008-10-10 2010-04-15 Cornell University Methods for predicting disease outcome in patients with colon cancer
US20120046186A1 (en) * 2010-08-20 2012-02-23 Pelham Robert J Gene Expression Markers for Prediction of Response to Platinum-Based Chemotherapy Drugs
JP2012083193A (ja) * 2010-10-12 2012-04-26 Univ Of Tokyo ヒストンタンパク質のグリコシル化を検出するための方法、並びに当該方法に用いられる抗体

Also Published As

Publication number Publication date
AU2014248966A1 (en) 2015-10-29
MX2015012124A (es) 2016-04-28
WO2014164805A1 (en) 2014-10-09
CA2905337A1 (en) 2014-10-09
BR112015022701A2 (pt) 2018-09-25
KR20150126048A (ko) 2015-11-10
CN105408480A (zh) 2016-03-16
SG11201507211YA (en) 2015-10-29
EP2970978A1 (en) 2016-01-20
US20170166897A1 (en) 2017-06-15
EP2970978A4 (en) 2016-11-02
RU2015138544A (ru) 2017-04-18
JP2016513968A (ja) 2016-05-19

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