MX2015012124A - Composiciones y metodos para dirigir n-acetilglucosamina transferasa o-enlazada y promover la sanacion de heridas. - Google Patents

Composiciones y metodos para dirigir n-acetilglucosamina transferasa o-enlazada y promover la sanacion de heridas.

Info

Publication number
MX2015012124A
MX2015012124A MX2015012124A MX2015012124A MX2015012124A MX 2015012124 A MX2015012124 A MX 2015012124A MX 2015012124 A MX2015012124 A MX 2015012124A MX 2015012124 A MX2015012124 A MX 2015012124A MX 2015012124 A MX2015012124 A MX 2015012124A
Authority
MX
Mexico
Prior art keywords
compositions
methods
targeting
wound healing
linked
Prior art date
Application number
MX2015012124A
Other languages
English (en)
Inventor
David Rubenstein
Kasper Runager
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of MX2015012124A publication Critical patent/MX2015012124A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01186—Glycogenin glucosyltransferase (2.4.1.186)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01255—Protein O-GlcNAc transferase (2.4.1.255)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Power Engineering (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

El tema actualmente descrito proporciona compuestos, composiciones y métodos para dirigir UDP-N acetilglucosamina polipéptido ß-N-acetilglucosaminil transferasa (OGT). Además, el tema actualmente descrito proporciona compuestos, composiciones y métodos para promover la sanación de heridas.
MX2015012124A 2013-03-11 2014-03-11 Composiciones y metodos para dirigir n-acetilglucosamina transferasa o-enlazada y promover la sanacion de heridas. MX2015012124A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361775937P 2013-03-11 2013-03-11
PCT/US2014/023525 WO2014164805A1 (en) 2013-03-11 2014-03-11 Compositions and methods for targeting o-linked n-acetylglucosamine transferase and promoting wound healing

Publications (1)

Publication Number Publication Date
MX2015012124A true MX2015012124A (es) 2016-04-28

Family

ID=51658978

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012124A MX2015012124A (es) 2013-03-11 2014-03-11 Composiciones y metodos para dirigir n-acetilglucosamina transferasa o-enlazada y promover la sanacion de heridas.

Country Status (13)

Country Link
US (1) US20170166897A1 (es)
EP (1) EP2970978A4 (es)
JP (1) JP2016513968A (es)
KR (1) KR20150126048A (es)
CN (1) CN105408480A (es)
AU (1) AU2014248966A1 (es)
BR (1) BR112015022701A2 (es)
CA (1) CA2905337A1 (es)
CL (1) CL2015002599A1 (es)
MX (1) MX2015012124A (es)
RU (1) RU2015138544A (es)
SG (1) SG11201507211YA (es)
WO (1) WO2014164805A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111234022B (zh) * 2019-12-16 2024-03-22 江苏省药物研究所有限公司 抗n-乙酰氨基葡萄糖转移酶修饰的蛋白质单克隆抗体及杂交瘤细胞株和其制备方法与应用
CN112707955B (zh) * 2020-12-21 2022-01-18 山东润德生物科技有限公司 提高N-乙酰氨基葡萄糖产量的RamAM转录因子突变体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108367A0 (en) * 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
WO1998044123A2 (en) * 1997-03-31 1998-10-08 The Government Of The United States Of America Represented By The Secretary Of The Department Of Health And Human Services O-LINKED GlcNAc TRANSFERASE (OGT): CLONING, MOLECULAR EXPRESSION, AND METHODS OF USE
AU5337499A (en) * 1998-08-03 2000-03-06 East Carolina University Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
AU776512B2 (en) * 1999-01-27 2004-09-09 David Laurence Becker Formulations comprising antisense nucleotides to connexins
US20090117599A1 (en) * 2005-12-22 2009-05-07 Jun Hirabayashi METHOD OF DETECTING SUGAR CHAINS HAVING GlcNAc TRANSFERRED BY GnT-V
US20110257034A1 (en) * 2008-10-10 2011-10-20 Cornell University Methods for identifying genes which predict disease outcome for patients with colon cancer
US20120046186A1 (en) * 2010-08-20 2012-02-23 Pelham Robert J Gene Expression Markers for Prediction of Response to Platinum-Based Chemotherapy Drugs
JP2012083193A (ja) * 2010-10-12 2012-04-26 Univ Of Tokyo ヒストンタンパク質のグリコシル化を検出するための方法、並びに当該方法に用いられる抗体

Also Published As

Publication number Publication date
US20170166897A1 (en) 2017-06-15
EP2970978A4 (en) 2016-11-02
EP2970978A1 (en) 2016-01-20
RU2015138544A (ru) 2017-04-18
JP2016513968A (ja) 2016-05-19
CA2905337A1 (en) 2014-10-09
CN105408480A (zh) 2016-03-16
AU2014248966A1 (en) 2015-10-29
KR20150126048A (ko) 2015-11-10
SG11201507211YA (en) 2015-10-29
BR112015022701A2 (pt) 2018-09-25
WO2014164805A1 (en) 2014-10-09
CL2015002599A1 (es) 2016-08-26

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