CA2333901A1 - Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments - Google Patents
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments Download PDFInfo
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- CA2333901A1 CA2333901A1 CA002333901A CA2333901A CA2333901A1 CA 2333901 A1 CA2333901 A1 CA 2333901A1 CA 002333901 A CA002333901 A CA 002333901A CA 2333901 A CA2333901 A CA 2333901A CA 2333901 A1 CA2333901 A1 CA 2333901A1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
Abstract
A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, intron and exon borders and all regulatory and functionally related segments of the genes and mRNAs encoding the polypeptides, their salts and mixtures.
Various formulations contain a requisite carrier, and optionally other additives and biologically active agents. The agent of the invention may be prepared by selecting a target gene(s), genomic flanking region(s), RNA(s) and/or polypeptide(s) associated with a disease(s) or condition(s) afflicting lung airways, obtaining the sequence of the mRNA(s) corresponding to the target gene(s) and/or genomic flanking region(s), and/or RNAs encoding the target polypeptide(s), selecting at least one segment of the mRNA which may be up to 60 % free of thymidine (T) and synthesizing one or more anti-sense oligonucleotide(s) to the mRNA segments which are free of adenosine (A) by substituting a universal base for A when present in the oligonucleotide. The agent may be prepared by selection of target nucleic acid sequences with GC
running stretches, which have low T content, and by optionally replacing A in the anti-sense oligonucleotides with a AUniversal base@. The agent, composition and formulations are used for prophylactic, preventive and therapeutic treatment of ailments associated with impaired respiration, allergy(ies) and/or inflammation, such as pulmonary vasoconstriction, inflammation, allergies, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, pulmonary hypertension and bronchoconstriction, chronic bronchitis, emphysema, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), ischemic conditions including ischemia itself, and cancers such as leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, pancreatic cancer, lung cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastasis, etc., as well as all types of cancers with may metastasize or have metastasized to the lung(s), including breast and prostate cancer. The present treatment is suitable for administration in combination with other treatments, e.g. before, during and after other treatments, including radiation, chemotherapy, antibody therapy and surgery, among others. The present agent is effectively administered preventatively, prophylactically or therapeutically by itself for conditions without known therapies, or as a substitute for, or in conjunction with, other therapies exhibiting undesirable side effects. The treatment of this invention may be administered directly into the respiratory system of a subject, so that the agent has direct access to the airways and the lungs.
Various formulations contain a requisite carrier, and optionally other additives and biologically active agents. The agent of the invention may be prepared by selecting a target gene(s), genomic flanking region(s), RNA(s) and/or polypeptide(s) associated with a disease(s) or condition(s) afflicting lung airways, obtaining the sequence of the mRNA(s) corresponding to the target gene(s) and/or genomic flanking region(s), and/or RNAs encoding the target polypeptide(s), selecting at least one segment of the mRNA which may be up to 60 % free of thymidine (T) and synthesizing one or more anti-sense oligonucleotide(s) to the mRNA segments which are free of adenosine (A) by substituting a universal base for A when present in the oligonucleotide. The agent may be prepared by selection of target nucleic acid sequences with GC
running stretches, which have low T content, and by optionally replacing A in the anti-sense oligonucleotides with a AUniversal base@. The agent, composition and formulations are used for prophylactic, preventive and therapeutic treatment of ailments associated with impaired respiration, allergy(ies) and/or inflammation, such as pulmonary vasoconstriction, inflammation, allergies, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, pulmonary hypertension and bronchoconstriction, chronic bronchitis, emphysema, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), ischemic conditions including ischemia itself, and cancers such as leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, pancreatic cancer, lung cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastasis, etc., as well as all types of cancers with may metastasize or have metastasized to the lung(s), including breast and prostate cancer. The present treatment is suitable for administration in combination with other treatments, e.g. before, during and after other treatments, including radiation, chemotherapy, antibody therapy and surgery, among others. The present agent is effectively administered preventatively, prophylactically or therapeutically by itself for conditions without known therapies, or as a substitute for, or in conjunction with, other therapies exhibiting undesirable side effects. The treatment of this invention may be administered directly into the respiratory system of a subject, so that the agent has direct access to the airways and the lungs.
Description
DEMANDES OU BR~VEfS VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET
COMPREND PLUS D'UN TOME.
CECI EST LE TOME ~ _ DE
NOTE: Pour les tomes additiortels, veuillez contacter le Bureau canadien des brevets JUMBO APPLlCA'i'IONS/PATENTS I
. THIS IS VOLUME OF
NOTE:.For additional volumes~piease contact'the Canadian Patent Office EPI-I09 845 _ 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggc~aca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2391 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2901 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2691 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcc~ccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 9191 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 9321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 9381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 9441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 9861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 9921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5091 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5901 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID N0:2670:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (e) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2670 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaaqcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1991 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1791 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactqgaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2391 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2961 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3981 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3591 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3891 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961' tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 9021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 9081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4191 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 9321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 9561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 9741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 9921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 9981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5901 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID N0:2671:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2671 1 cgtgttgatg atggagtagc ttcctttgtg cttaatctcc catctggagt gacggtgctg 61 gagtttaatg tcaaaactga tgctccagat cttccagaag aaaatcaggc cagggaaggt 121 taccgagcaa tagcatactc atctctcagc caaagttacc tttatattga ttggactgat 181 aaccataagg ctttgctagt gggagaacat ctgaatatta ttgttacccc caaaagccca 291 tatattgaca aaataactca ctataattac ttgattttat ccaagggcaa aattatccac 301 tttggcacga gggagaaatt ttcagatgca tcttatcaaa gtataaacat tccagtaaca 361 cagaacatgg ttccttcatc ccgacttctg gtctattata tcgtcacagg agaacagaca 421 gcagaattag tgtctgattc agtctggtta aatattgaag aaaaatgtgg caaccagctc 481 caggttcatc tgtctcctga tgcagatgca tattctccag gccaaactgt gtctcttaat 591 atggcaactg gaatggattc ctgggtggca ttagcagcag tggacagtgc tgtgtatgga 601 gtccaaagag gagccaaaaa gcccttggaa agagtatttc aattcttaga gaagagtgat 661 ctgggctgtg gggcaggtgg tggcctcaac aatgccaatg tgttccacct agctggactt 721 accttcctca ctaatgcaaa tgcagatgac tcccaagaaa atgatgaacc ttgtaaagaa 781 attctcaggc caagaagaac gctgcaaaag aagatagaag aaatagctgc taaatataaa 891 cattcagtag tgaagaaatg ttgttacgat ggagcctgcg ttaataatga tgaaacctgt 901 gagcagcgag ctgcacggat tagtttaggg ccaagatgca tcaaagcttt cactgaatgt 961 tgtgtcgtcg caagccagct ccgtgctaat atctctcata aagacatgca attgggaagg 1021 ctacacatga agaccctgtt accagtaagc aagccagaaa ttcggagtta ttttccagaa 1081 agctggttgt gggaagttca tcttgttccc agaagaaaac agttgcagtt tgccctacct 1141 gattctctaa ccacctggga aattcaaggc attggcattt caaacactgg tatatgtgtt 1201 gctgatactg tcaaggcaaa ggtgttcaaa gatgtcttcc tggaaatgaa tataccatat 1261 tctgttgtac gaggagaaca gatccaattg aaaggaactg tttacaacta taggacttct 1321 gggatgcagt tctgtgttaa aatgtctgct gtggagggaa tctgcacttc ggaaagccca 1381 gtcattgatc atcagggcac aaagtcctcc aaatgtgtgc gccagaaagt agagggctcc 1991 tccagtcact tggtgacatt cactgtgctt cctctggaaa ttggccttca caacatcaat 1501 ttttcactgg agacttggtt tggaaaagaa atcttagtaa aaacattacg agtggtgcca 1561 gaaggtgtca aaagggaaag ctattctggt gttactttgg atcctagggg tatttatggt 1621 accattagca gacgaaagga gttcccatac aggataccct tagatttggt ccccaaaaca 1681 gaaatcaaaa ggattttgag tgtaaaagga ctgcttgtag gtgagatctt gtctgcagtt 1791 ctaagtcagg aaggcatcaa tatcctaacc cacctcccca aagggagtgc agaggcggag 1801 ctgatgagcg ttgtcccagt attctatgtt tttcactacc tggaaacagg aaatcattgg 1861 aacatttttc attctgaccc attaattgaa aagcagaaac tgaagaaaaa attaaaagaa 1921 gggatgttga gcattatgtc ctacagaaat gctgactact cttacagtgt gtggaagggt 1981 ggaagtgcta gcacttggtt aacagctttt gctttaagag tacttggaca agtaaataaa 2041 tacgtagagc agaaccaaaa ttcaatttgt aattctttat tgtggctagt tgagaattat 2101 caattagata atggatcttt caaggaaaat tcacagtatc aaccaataaa attacagggt 2161 accttgcctg ttgaagcccg agagaacagc ttatatctta cagcctttac tgtgattgga 2221 attagaaagg ctttcgatat atgccccctg gtgaaaatcg acacagctct aattaaagct 2281 gacaactttc tgcttgaaaa tacactgcca gcccagagca cctttacatt ggccatttct 2341 gcgtatgctc tttccctggg agataaaact cacccacagt ttcgttcaat tgtttcagct 2901 ttgaagagag aagctttggt taaaggtaat ccacccattt atcgtttttg gaaagacaat 2961 cttcagcata aagacagctc tgtacctaac actggtacgg cacgtatggt agaaacaact 2521 gcctatgctt tactcaccag tctgaacttg aaagatataa attatgttaa cccagtcatc 2581 aaatggctat cagaagagca gaggtatgga ggtggctttt attcaaccca ggacacaatc 2641 aatgccattg agggcctgac ggaatattca ctcctggtta aacaactccg cttgagtatg EPI-109 g4g 2701 gacatcgatg tttcttacaa gcataaaggt gccttacata attataaaat gacagacaag 2761 aatttccttg ggaggccagt agaggtgctt ctcaatgatg acctcattgt cagtacagga 2821 tttggcagtg gcttggctac agtacatgta acaactgtag ttcacaaaac cagtacctct 2881 gaggaagttt gcagcttt~a tttgaaaatc gatactcagg atattgaagc atcccactac 2991 agaggctacg gaaactctga ttacaaacgc atagtagcat gtgccagcta caagcccagc 3001 agggaagaat catcatctgg atcctctcat gcggtgatgg acatctcctt gcctactgga 3061 atcagtgcaa atgaagaaga cttaaaagcc cttgtggaag gggtggatca actattcact 3121 gattaccaaa tcaaagatgg acatgttatt ctgcaactga attcgattcc ctccagtgat 3181 ttcctttgtg tacgattccg gatatttgaa ctctttgaag ttgggtttct cagtcctgcc 3241 actttcacag tgtacgaata ccacagacca gataaacagt gtaccatgtt ttatagcact 3301 tccaatatca aaattcagaa agtctgtgaa ggagccgcgt gcaagtgtgt agaagctgat 3361 tgtgggcaaa tgcaggaaga attggatctg acaatctctg cagagacaag aaaacaaaca 3421 gcatgtaaac cagagattgc atatgcttat aaagttagca tcacatccat cactgtagaa 3981 aatgtttttg tcaagtacaa ggcaaccctt ctggatatct acaaaactgg ggaagctgtt 3541 gctgagaaag actctgagat taccttcatt aaaaaggtaa cctgtactaa cgctgagctg 3601 gtaaaaggaa gacagtactt aattatgggt aaagaagccc tccagataaa atacaatttc 3661 agtttcaggt acatctaccc tttagattcc ttgacctgga ttgaatactg gcctagagac 3721 acaacatgtt catcgtgtca agcattttta gctaatttag atgaatttgc cgaagatatc 3781 tttttaaatg gatgctaaaa ttcctgaagt tcagctgcat acagtttgca cttatggact 3841 cctgttgttg aagttcgttt ttttgttttc ttcttttttt aaacattcat agctggtctt 3901 atttgtaaag ctcactttac ttagaattag tggcacttgc ttttattaga gaatgatttc 3961 aaatgctgta actttctgaa ataacatggc cttggagggc atgaagacag atactcctcc 4021 aaggttattg gacaccggaa acaataaatt ggaacacctc ctcaaaccta ccactcagga 9081 atgtttgctg gggccgaaag aacagtccat tgaaagggag tattacaaaa acatggcctt 4141 tgcttgaaag aaaataccaa ggaacaggaa actgatcatt aaagcctgag tttgctttc 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 921 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1991 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041'agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2901 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2961 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt EPI-l09 B49 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2691 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcc~ccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccacaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3291 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3591 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 9141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 9261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 9381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4941 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 9561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 9681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 9981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5391 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 291 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 981 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661'tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1191 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1941 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2691 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3291 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3921 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3891 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 9081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 9141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 9261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 9321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 9381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4941 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 9501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 9741'tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 9921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5091 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac WO 00/09525 ~ PCT/US99/17712 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaacLga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID N0:2672:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2672 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1791 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181.tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3921 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3981 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3591 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc WO 00/09525 PCTlUS99/17712 EPLl09 852 3891 aatatcacta cagatcc=ac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctt~aat cccagcactt tgggagggct aggaaggcgg atcacgaggt 9081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 9191 aattagccag gcttggt;gt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 9201 agaattgctt gaacctc~ga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 9261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 9381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 9941 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 9621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 9681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 9791 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 9801 caaqagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 9861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 9981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtqatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctq ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6291 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6981 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6591 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6891 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7191 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7941 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7791 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8091 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tatttt_ctt tttgtatgtg 8901 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8961 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8691 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttaqttc 9121 taacagactt attctatga'a tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc 9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9981 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10191 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaasg gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10491 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10791 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11091 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc 11391 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11961 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11991 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12291 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12981 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 126D1 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12891 atacagaaag ~ggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ~cttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 19041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 19161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 19221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14391 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14901 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 19691 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 19701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14991 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15591 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15891 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattggga ggacacagga catccaatta gagagtgccc aagggggtcc 16191 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttg-a 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17901 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17961 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctagqt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18291 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18921 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19791 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20691 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21291'catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct EPI-f 09 856 21841 ggagagccct taggacct:g tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22191 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22491 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23091 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23901 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23961 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23691 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23991 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 29121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 29181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 29301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 29361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 29921 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 29481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24591 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 29721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 29781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 29901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25191 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25791 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26091 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26341 tqagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26961 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26691 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27921 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27591 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28191 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28491 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28791 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29961 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29691 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29991 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30291 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30921 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30591 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc ~gataatacc tagtactgag ttggagtaat agaaactgct aatgggacag EPI-f 09 g5g 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32961 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33591 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta 33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 39021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 39081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 39321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 39991 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 39621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 39921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35091 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35901 tgcattgaca ctgtaga~ag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36891 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37191 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38091 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38691 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39291 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39981 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctc~ggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 90081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40191 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 90201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 90261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 90941 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 40791 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 90801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 91041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 91221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 91941 aagttaccat gagataggag aaacasgtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 92181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 92301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 92361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 92421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 92541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 92721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 92781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagatgaga ggcaggggtg 92901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 92961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 93141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 93321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 93501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg 93681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 93741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 93801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta 93861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 93921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 93981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 49041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 99161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 94221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 49281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc W O 00/09525 PCTNS99/i 7712 EPI-109 g61 99341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 49461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 94521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 49581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 94641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 99701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 49761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 94821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 94991 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 95061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 95121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 95181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 95241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaatta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 95421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 95981 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 95541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 95601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 95781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 95961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 96201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 96441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 96561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 96621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 96741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 96801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 96861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 96921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 96981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47391 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 97461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47581 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 97641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 97821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 97881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 98121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 98181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 98421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 98981 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 98541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 98661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 98781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48891 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 98901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 99021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 99081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 99141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 99201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 99381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 99941 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtg.cgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49791 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 99921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50091 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcqgagc ttgcagtgag ccgagatcgg 50391 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50901 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50961 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50691 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50991 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51981 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52191 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52491 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat EPI-109 863 _ 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53691 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 59001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 59061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 59301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 59361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54921 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatCt tctagtaagc cctgggagag 59781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 59841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 59901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 59961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55191 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55791 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56091 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56901 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56991 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181, cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57981 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaa't tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg 57891 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58191 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga.gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58991 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59391 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59901 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59961 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttaca ggaa 59691 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggcttgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactgagttg cagctgggca 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61191 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61491 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741'gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg EPI-!09 865 62391 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62691 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63981 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtca ca g 63591 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 69141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 69201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 69621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 69681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 69861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 69921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 69981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65961 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65641 tggagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca ggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66291 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt _ccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa EPI-109 g~
66891 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67191 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67491 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67791 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68091 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68282 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68391 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68961 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68642 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aagqggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69291 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69981 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70491 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70791~tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71091 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71991 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72591 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73191 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg qtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 79281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca 79341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca 79401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 79961 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg 79521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 79701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74991 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241~gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75591 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag EPI-109 868 _ 75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca .
76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76791 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77691 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78291 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79991 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80691 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82491 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82791 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt qtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83991 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 89001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 89181,gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 89241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 89361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 84981 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 89591 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 89601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact EP1-109 g70 84841 ccaatgatga ~ggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 89901 ctcctgtgca cgtgac~~cc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 84961 cattgtggct ~tagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaacct~:.ca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcc:.gt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc ~gctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85491 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaactag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86901 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86961 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcascgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87591 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88941 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagt,g gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc WO 00!09525 PCTNS99/17712 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89901 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89991 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90981 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90591 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90891 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91191 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91491 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa 92391 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92691 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181.tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93921 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93591 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt EPl-109 872 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaag~ctg acttgacttt 99021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 99201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttct.:cct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 99941 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 99621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 99681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 99801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 99921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa 95091 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96291 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96591 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata 96891 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97191 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97991 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgt~cac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741~aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98391 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt 99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99921 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat 99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99591 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg 99891 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100491 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101901 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101961 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101691 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181. agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102421 ttagtataag tacaaccca.t atacgacaat tgcagtattt gttatttatc tgaaattcag 102981 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt ' 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 109041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 109101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 109161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 109221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 109901 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 109461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 109581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 109641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 109701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 109821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104991 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105291 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105591 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact 105891 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106941 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681. tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca EP!-109 875 107391 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107961 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107991 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108291 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108981 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108891 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109991 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcasggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109791 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg 110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110901 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcatttt'c cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111921 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt EPI-109 g~6 111891 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112941 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113391 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113901 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113961 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113691 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113991 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 119001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 119061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 119121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 119541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 119781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 114891 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 119961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115941 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681.cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116091 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116961 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117291 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117921 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117591 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118791 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt 119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119901 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119991 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181,gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120591 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120891 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121491 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122091 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122391 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122901 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa_cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123591 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac 123891 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 129261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 129381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 129991 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 129681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 129922 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 129982 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125391 gagggtggtc ctgacctaca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125901 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126921 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127191 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127791 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128901 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129921 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129841 acagatgtta tcatgttytc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130791 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131091 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggct3tt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131901 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131961 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131991 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132291 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132981 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132591 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133191 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133941 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaaett gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 139101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagct=ctac agcaacaaac 134391 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 139401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 139461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 139521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 139881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135291 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135921 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135891 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136941 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136791 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137091 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc 137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137961 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt etccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcc~gggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138891 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139941 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140091 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 190221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 190281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 190341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 190401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 190761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 190881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 190991 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 191061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141921 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 191541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 191601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 191661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 191721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 191961 cagcttggtg atcctggqtg catgtggggt ctgtctctgg tggccctggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 192081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 192561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681'aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143091 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID N0:2673:
(i) SEQUENCE CHARACTERISTICS:
EPI-109 gg3 (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: s'_ngle (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2673 1 gagctcagaa attcaa~acc agcctgggca aggtagagag acccccatgt ctacaaaaaa 61 taaaaaatga ttagtca~gt gtggtggccc gcacctgtag ttccagctac tcaggacgct 121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac 181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 291 aaccatcaaa atgttt=.:ca cagcagtcac gccattttac atttctgcca gcaatgtgca 301 ccaggcttcc agtttct=ca catcttcact aactcttatt tcctttgctt taaactctaa 361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact 421 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt 481 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt 541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg 601 tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc 661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt 721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg 781 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc 891 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct 901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac 961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa 1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt 1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag 1191 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag 1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg 1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat 1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca 1381 ggctggtctt gattcctygc ttcaagagat gctcttacct ccacctcctg aagcccaaag 1941 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt 1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc 1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc 1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac 1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca 1741 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag 1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact 1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa 1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg 1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg 2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt 2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg 2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta 2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag (2) INFORMATION FOR SEQ ID N0:2674:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2679 1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 181 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 291 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 921 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 481 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 591 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 841 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta 1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga 1191 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc 1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt 1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc 1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt 1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc 1991 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg 1501 gttctttttc ttcggtaggc (2) INFORMATION FOR SEQ ID N0:2675:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2675 1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc 61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc 121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc 181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat 241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac 301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag 361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac 921 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc 981 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgggcc 591 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg 601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa 661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag 721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg 781 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg 891 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc 901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc 1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc 1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt 1141 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac 1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc 1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg 1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata 1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc 1441 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac 1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc 1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag 1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt 1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc 1741 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag 1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc 1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc 1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag 1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc 2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg 2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg 2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc 2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg 2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc 2341 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca 2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag 2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag 2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac 2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct 2641 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg 2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa 2761 aaaataaaac ttcaat (2) INFORMATION FOR SEQ ID N0:2676:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2676 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 921 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 981 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 591 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1941 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1791 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID N0:2677:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2677 1 gagctcagaa attcaagacc agcctgggca aggtagagag acccccatgt ctacaaaaaa 61 taaaaaatga ttagtcaggt gtggtggccc gcacctgtag ttccagctac tcaggacgct 121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac 181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 241 aaccatcaaa atgttttgca cagcagtcac gccattttac atttctgcca gcaatgtgca 301 ccaggcttcc agtttcttca catcttcact aactcttatt tcctttgctt taaactctaa 361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact 921 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt 4B1 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt 541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg 601,tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc 661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt 721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg 7B1 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc 891 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct 901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac 961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa 1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt 1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag 1191 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag 1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg 1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat 1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca 1381 ggctggtctt gattcctggc ttcaagagat gctcttacct ccacctcctg aagcccaaag 1941 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt 1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc 1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc 1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac 1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca 1791 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag 1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact 1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa 1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg 1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg 2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt 2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg 2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta 2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag 1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 1B1 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 241 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 421 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 981 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 541 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 891 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta 1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga 1141 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc 1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt 1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc 1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt 1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc 1441 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg 1501 gttctttttc ttcggtaggc 1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc 61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc 121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc 181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat 241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac 301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag 361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac 921 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc 481 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgqgcc 541 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg 601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa 661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag 721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg 7B1 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg B41 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc 901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc 1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc 1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt 1191 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac 1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc 1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg 1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata 1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc 1491 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac 1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc 1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag 1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt 1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc 1791 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag 1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc 1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc 1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag 1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc 2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg 2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg 2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc 2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg 2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc 2391 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca 2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag 2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag 2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac 2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct 2691 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg 2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa 2761 aaaataaaac ttcaat 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 18i ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 922 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 591 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1191 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1941 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2091 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID N0:2678:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2678 1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 291 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 9B1 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 591 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gqgggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1191 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaa.g cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt (2) INFORMATION FOR SEQ ID N0:2679:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2679 1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct 61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg 121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg 181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg 291 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga 301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca 361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg 481 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 591 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc 781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg 1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc 1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg 1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc 1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac 1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg 1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat 1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa 1441,gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct 1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt (2) INFORMATION FOR SEQ ID NO:2680:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2680 EPI-l09 889 1 ggaattcc~g gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 291 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 921 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcct~tt cacgggaact 1941 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt 1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct 61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg 121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg 181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg 241 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga 301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca 361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg 981 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 541 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc 781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg 1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc 1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg 1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc 1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac 1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg 1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat 1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa 1491 gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct 1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt (2) INFORMATION FOR SEQ ID N0:2681:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENC~ DESCRIPTION: SEQ ID N0:2681 1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag 61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa 121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa 181 cttttttcct ~atgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc 241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc 301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt 361 ttaaaataat ctaaatataa ttattcctta tgccctgttt ttccctcact tttgtatcca 421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca 981 cttcaaaatg aattcaggat tgtaatgtaa aattttagta ctctctcaca gtatggattc 541 taacatggct tctaacccaa actaacatta gtagctctaa ctataaactt caaatttcag 601 tagatgcaac ctactcc~tt aaaatgaaac agaagattga aattattaaa ttatcaaaaa 661 gaaaatgatc cacgctctta gttgaaattt catgtaagat tccatgcaat aaataggagt 721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg 781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa 891 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg 901 tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt 961 aggacataac tgaattttct attttccact tcttttctgg tgtgtgtgta tatatatatg 1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc 1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc 1141 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa 1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat 1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac 1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc 1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc 1441 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc 1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt 1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc 1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt 1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca 1741 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct 1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga 1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga 1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc 1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg 2041 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg 2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc 2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga 2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg 2281 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac 2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc (2) INFORMATION FOR SEQ ID N0:2682:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2682 1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca 61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct 121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa 181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg 241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa 301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt 361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca 421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt 981 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc 541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct 601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc 661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa 721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg 781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta 891 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca 901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc 961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga 1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa 1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga 1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa 1201.caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata 1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt 1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc 1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc 1941 ttttaatgag taccgcaaac gctttatgct. gaagccctat gaatcatttg aagaacttac 1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga 1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat 1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc 1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc 1791 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt 1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact 1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa 1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt 1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2901 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata 2691 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2991 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag (2) INFORMATION FOR SEQ ID N0:2683:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2683 1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta 61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt 121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc 181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag 241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta 301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac 361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct 921 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc 981 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca 591 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga 601 caggagagtg gggactaccc cctctgctcc caaattgggg cagcttcctg ggtttccgat 661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaa gg 721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac 781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca 841 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag 901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg 961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg 1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc 1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact 1141 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca 1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa 1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata 1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt 1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg 1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat 1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta 1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg 1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt 1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat 1791 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg 1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg 1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga 1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca 1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatttctcc ctccctttct 2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttytga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagttt~cct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccattaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2991 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3291 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3421 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3981 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattc_ttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3891 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 9081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 4201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 9321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 9381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 9441 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 9501 taacttttta actgatgttt atttatttat ttattttttt agataattga tggagagatg 4561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 9681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4741 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 9801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 9921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 4981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5041 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat tccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5341 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5901 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5961 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581'tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5641 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6241 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6921 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6481 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6591 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc 6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact 6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc 6891 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg 6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt 6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta 7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat 7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa 7141 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga 7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg 7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt 7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat 7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa 7491 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt 7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa 7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc 7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca 7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag 7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc 7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta 7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg 7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc 7981 tgttgtacag tttaatttag cagtccatat cacattgcaa aagtagcaat gacctcataa 8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc 8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc 8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg 8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct 8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag 8341 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa 8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga 8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt 8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc 8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg 8641 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt 8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata 8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta 8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg 8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa 8991 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt 9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt 9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt 9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt 9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa 9241 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg 9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta 9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa 9921 aaaaaaaaaa aaaaatcgat gtcgactcga gtc (2) INFORMATION FOR SEQ ID N0:2689:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2684 1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag 61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa 121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa 181 cttttttcct tatgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc 241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc 301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt 361 ttaaaataat ctaaata~aa ttattcctta tgccctgttt ttccctcact tttgtatcca 421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca 481 cttcaaaatg aattcac~at tgtaatgtaa aattttagta ctctctcaca gtatggattc 541 taacatggct tctaacc:.aa actaacatta gtagctctaa ctataaactt caaatttcag 601 tagatgcaac ctactcc~tt aaaatgaaac agaagattga aattattaaa ttatcaaaaa 661 gaaaatgatc cacgctc~ta gttgaaattt catgtaagat tccatgcaat aaataggagt 721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg 781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa 841 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg 901 tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt 961 aggacataac tgaattt~ct attttccact tcttttctgg tgtgtgtgta tatatatatg 1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc 1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc 1191 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa 1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat 1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac 1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc 1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc 1941 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc 1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt 1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc 1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt 1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca 1791 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct 1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga 1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga 1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc 1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg 2091 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg 2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc 2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga 2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg 228 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac 2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc 1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca 61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct 121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa 181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg 291 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa 301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt 361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca 921 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt 481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc 591 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct 601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc 661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa 721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg 781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta 891 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca 901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc 961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga 1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa 1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga 1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa 1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata 1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt 1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc 1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc 1491'ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac 1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga 1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat 1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc 1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc 1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt 1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact 1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa 1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt 1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2901 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttt:.cac caagagtata 2691 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2991 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag 1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta 61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt 121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc 181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag 241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta 301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac 361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct 921 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc 481 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca 541 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga 601 caggagagtg gggactaccc cctctgctcc caaattgggg cagcttcctg ggtttccgat 661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaagg 721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac 781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca 891 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag 901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg 961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg 1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc 1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact 1191 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca 1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa 1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata 1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt 1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg 1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat 1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta 1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg 1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt 1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat 1741 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg 1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg 1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga 1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca 1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatt:ctcc ctccctttct 2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttgtga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagtttgcct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccattaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca EPI-l09 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2941 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3241 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3921 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3481 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattctttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3841 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 9081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 9201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 9321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 9381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 4491 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 9501 taacttttta actgatgttt atttatttat ttattttttt agataattga tggagagatg 9561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 4681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4791 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 9801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 4921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 9981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5091 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat ~ccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5391 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5401 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5961 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581 tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5691 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6291 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6921 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6981 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6541 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc 6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact 6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc 6891 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg 6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt 6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta 7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat 7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa 7191 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga 7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg 7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt 7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat 7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa 7941 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt 7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa 7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc 7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca 7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag 7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc 7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta 7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg 7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc 7981 tgttgtacag tttaatttag cagtccatat cacattgcaa.aagtagcaat gacctcataa 8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc 8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc 8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg 8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct 8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag 8391 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa 8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga 8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt 8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc 8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg 8691 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt 8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata 8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta 8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg 8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa 8991 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt 9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt 9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt 9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt 9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa 9291 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg 9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta 9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa 9921 aaaaaaaaaa aaaaatcgat gtcgactcga gtc (2) INFORMATION FOR SEQ ID N0:2685:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2685 1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 921 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 981 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga 661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc EPI-109 g9g 841 tgctagggat gttagacgga attcc (2) INFORMATION FOR SEQ ID N0:2686:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2686 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc (2) INFORMATION FOR SEQ iD N0:2687:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2687 1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 981 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 591 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 841 ttaataaaaa a (2) INFORMATION FOR SEQ ID N0:2688:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2688 1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg 61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga 121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt 181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa 241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag 301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa 361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg 421 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt 981 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag 591 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa 601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt 661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg 721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact 781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag (2) INFORMATION FOR SEQ ID N0:2689:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single ('D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2689 1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat 61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc 181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt 241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc &PI-109 899 _ 421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag 481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc 901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc 1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc 1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg 1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg 1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc 2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2391 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2901 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2691 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca 3061 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3921 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 9021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 9081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 9191 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 9201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 9321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 9941 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac EPI-109 900 _ 4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 9681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4791 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 9861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 9921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 9981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5091 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5961 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5691 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5991 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt qtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6981 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t (2) INFORMATION FOR SEQ ID N0:2690:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2690 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca 291 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 541 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc (2) INFORMATION FOR SEQ ID N0:2691:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2691 1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 921 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 481 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga 661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc 841 tgctagggat gttagacgga attcc 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc 1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 481 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 541 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 841 ttaataaaaa a 1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg 61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga 121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt 181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa 241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag 301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa 361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg 921 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt 481 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag 541 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa 601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt 661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg 721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact 781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag 1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat 61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc 181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt 241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc 421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag 481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 891 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc 901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc 1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc 1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1191 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1941 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg EPl-109 902 _ 1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1621 gcagacgcca ccgccgagca aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 2681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg.
1791 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc 2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2991 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3061 a~catcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca g gggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3291 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 9081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 9141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 9261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 9991 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac 9501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 9561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 9681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 9921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5091 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5162 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5691 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6291 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6921 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6981 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca 291 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 591 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc (2) INFORMATION FOR SEQ ID N0:2692:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2692 1 gatctgtcta gggctgtcag tggagtattg aagtccccca cgattattgt gttactgtct 61 atctcatttc ttaggtctat taataacagg tttttttgtt ttgttttgtt ttgttttgtt 121 tttttgagat ggagttttgc tcttgttgcc caggctggag tgcaatggca tgatctcagc 181 tcactgcaac ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagcagc 291 tgggactaca ggcatgcacc accacacctg gctaattttg tatttttagt agagacaagg 301 gttctccatg ttggtcaggc tggtcttgaa ctcccgacct ctggtgatct tcccacctca 361 gcctcccaaa gcgctgggat tacaggcatg agccaccgtg cccggcccat agtaactgtt 921 ttataaattt gggagctcca gtgtttagta catatatgtt tagaattgtg atatttccct 981 gttggacaag gccttttacc attatataat gccctctttt gtctctttta gctgctgttg 541 ctttaaaatt tgttttgtct gatataagaa tagctacctc tgctcacttt tggtgtctat 601 gtgcatgaaa tgcctttctc caccccttta ctttatgtga gtccttatgt gttgttaggc 661 cagcatcacc ctaatatcaa aaccagcaaa ggacatacca aaaaagaaca ttacagacca 721 atatttttga tgaacacaga tgctaaaatc ctcaacaaaa tactagctaa ccagttgcaa 781 caacatacca aaaagataat ccaccatgat caagtaagtt tcgtaccagg gatgcagaaa 841 agcagcagat ggtttgtgag ttcttatcta ttctgcaatt ctgtagaaaa gtggagcatt 901 taggccattt acattcaatg ttagtattga aatttgaggt accattgcat tcatcatgct 961 ctttgttgcc tgcgtacttt ggtttgtttt ttgattttgc tctttaactt gtatttttgt 1021 tttataggtc ctgtgtgatt tatgctttaa agagattctg ttttgatgtg tttccaggat 1081 ttctttcaag atttagagct cctttaaaca gttcttgtag cagtgccttg gtaatggcaa 1141 attctctcag tatttgtttg tctgaaaacg actgtatctt tccttcatat gtgatgctta 1201 gtttcactgg atgcaaaatt cttgactgat aattgttttg tttgaggagg ctgaagatag 1261 ggccccaacc ccttctagct tgtagggtct ctgctgagaa atctgctatt aatctgatag 1321 gttttcctta taggttacct ggtgcttctg tctcacagct cttaagattc tttccttggt 1381 cttaactttg tataacctga cgacaatgtg cctaggtgaa tatctttttg tatccatcgc 1941 ccaggctgga gtgcagtggc gcaattttgg ctcactgcaa cctctgcctc ccaggttcaa 1501 gcaattctcc tgcctcagcc tcccaaggag ctgggattac aggctcctgc caccacaccc 1561 agctaatttt ttttttttgt atttttagta gagacagggt tttgccatgt tggccagcct 1621 ggtctcaaac tcctgacctc aggtgatcca cctgcctcgg cctcccaaag tgctaggatt 1681 acaggcgtga gcccccgcac ccgagccctg atattaattt ttaaattaaa agactttatt 1741 tttaaaagca gtttgaggtt tacagaaaaa ctgagcagaa agtacagtct ctatataccc 1801 cctactccct gcccccagtt ttccctgtta ttaacatttg tgttaatgtg gcatatttgt 1861 tacaatcagt gaatcaatat tgataaatta aagtccatat gttagtgttc actctgtgtg 1921 ttatacagtt ctatgggttt tgccaaatgt attaatatgt catgtatcca tcattacagt WO 00/09525 PCfNS99/17712 1981 atcatccagc ataatttcac tgtcctgaaa atgccctgtg ctccacttat tcatcttttc 2091 cccacttgct atcaccacac caaagccctc acaaccactt atctttttaa tatatccata 2101 gttttgcctt ttgcagaaca tcatatcatt agaatcacaa taatatgtgg cttttcagac 2161 tggtttcttt cactcagcaa catgcagtta agggtcttcc gggtcttttg tggcttgaca ' 2221 gctcatttct ttttatcact gaataatatt gcattgtata gatataccac agtttttttt 2281 aaatttactc atcattaaag gacatcttga ttacttctaa tttctggcaa taatgaataa 2391 agttgataca aaaacttttg tgtaggattt tgtgtggaca tatgttttca actcattgag 2401 gtaaatgcct aaggcatatt tagttttgta agaaactgct aaactatctt ccaaagtatc 2961 tgtaccattt tgcattccca ccagctatga aagagtttct gttctacatc ttcacaaaca 2521 ttggtgttat cagtgttttg gattttagcc attctaattg gtgtggagtg gtatctcatt 2581 gttgttttaa ttttgcaatt ccctaatgac atatatgttg agcatctttt catatgcata 2641 tttaccatct gtatatcttc tttgggcata tgtccattca gatcttttgc acatcttttc 2701 attgggttgc tcattttctt attgagtttt aagagttctt catatatttt tgataacagt 2761 cctttatcag atatgtcttc tgcaaatatt ttctcccagt ctttgtcgtg tcttttcatt 2821 tacttaacag tgtctttcat aaaacagaag gttttaactt tgatgaagtc taacttgcca 2881 attttttctt tcatggattg tgctttgtgt gttgtatcta aaaactcatt gccaaacaca 2991 aggtcacctc tatgttctcc tatgttatct tctagaagct ttgtagtttt ctgttttaca 3001 tttatagggg ctgtgagaag gtgacagagg ttacatgagg taataaggat agggccttag 3061 ttgaataagg ctagtgccct tataagagga agagacgcca gttttctctc tctctaccat 3121 acgaagacac agcaagaaag tggccatcta caagtcaaga agtgggccat caccagaaac 3181 caaattactg gcaccttgat cttaaacttc ccagcttcca aaactgtgag aaataaattt 3291 ctgctgttta agccatgcaa cctacagtat aagttatagc agcccaagca gactaagaca 3301 gaacccttag catattaatc atagttactt taaatctctg gtcccataat tccaaaatat 3361 ctgccacatc tgagtctggt tctagtgctt gctttgtttc ttcaagactg tggttttttt 3921 tctcttttta gcatatctta taatttttct gttcaaagca aggcatgatg tactgggtaa 3981 agggaactga actgaggtag ataggtgttt agaatgaaat ttagaggcaa cttaagaaag 3541 tactcaaaaa acaaaattat gggagcatgc taaatggaca caggagccag cctgaaagag 3601 cttgcaatgg acaaagttgg aacaatttga gcaacaaaat aagttattct tccttataga 3661 ggaattctaa ataatttata tagatacttg ccttccagga agtggcactt aatccccatc 3721 aaaccctcat aagtgtgggc tggacttggt aacttccttc caaaaaatag agtatggaaa 3781 aggggtgaag taacttcata gtggaaaaac ctggcaaaca ctaccttggt tagctgagca 3891 aagccttgat atggtgtgat gagaatggaa tattaccttt gtgatctttc tctcaaacac 3901 ttataatccc attctaatca tgaggaaagc gtaagacaaa tcccaattga gggacattct 3961 acaaaatacc tgaggagtac tcctcaatag gtcatcaaaa caagtcttag aaactgtcac 4021 agtcaagaag aaactaagga aaaatgacaa ctaaatgcaa tgtggtatca tggactggct 9081 cctagaacag aaaaagtcag tatataaaaa ctaagaaaat ctgaataaag tatggacttt 9191 agtgataata atgtatcaat attggtttat tacttgtagc aaatgtacca tactaatcta 9201 agatgataat aaaaacaata actctgtgta gggccaaagg gagggaagtg ggctgatacg 4261 ggaactctcc gcactatctt agcaactttt tggcaaatct aaaattactc caagatacta 4321 agcttctttt ttaaaaaaaa tcacaaaacc tgaaaaattt taaagaaata aaaatttaaa 9381 aattaaaaag agtcaaatcc cagctgtatt tttattaatt atgtaatatt gtacaagtca 4441 ctctctgagc tttggtgtcc ctgtttataa aagtgataga atacattttt gagtgacatc 4501 tgaaagatag cagagtagga agctccaggc cctcctttcc ccatgtaatc tgtgaaagga 9561 aattcaattt cgggacgcca aactcattta gcgaaaggga aaagtcaaag tgggaactgg 9621 gtcatgcaaa cctgcctccc acttttgggt cctcaataag atggctacaa gatgaaaagc 4681 tacatgcctc cgccatattt tgcccacaag gaaattccta gtgagttgtt aaaatttcac 9741 cgtagcaatg caaattgata gcttatcttt acaggtgcag tcgcccccgg cgcactagac 9801 ataaatgcac atctgagtgt tcccctgccc cattttgtcc atgttatctt atgtaaaatg 9861 catattcccc acatttttcc tctgcctctt ttatgtcatc ttattaatgc agattccctg 9921 agccagacaa aggcatgaat gactattttt ccctaccctc ctcttacatg aaaattgtgt 4981 acttctcagt atcgcaccct ttccccttta aattttgagc cctcaaaatc atcttcggag 5041 acaggcatag acctgtctcc tgagtgcatc cttaactttg gcaaataaat cccctaaaat 5101 gattgagact tgtcattttt ctcaattgac atctggtaac cacgaaggga tcctgagtga 5161 aagtgaccca gcctgcagta gctcacctct cagtgcttgg caccggcttg gtcaccttat 5221 agcccaaact gagaggacaa tttgccaaag tcgaggacct ctttccaggg atctctgatc 5281 ttccaacatt ttccagttgg gggtctgaag tttatttgct gttaaaaaca aaacaaaaca 5341 acaaaaacaa caaaaattcc tttttttgta ggcgtttcca ctcacttcca tcaaggaagg 5401 cgagcctgtc tgcttctgca tatgcagaga gcaatcttca gcttgggccc ccatcactag 5461 gtaagaaact ggtttggaat tctgtcttgc aaattctttt aaacgactag aattagcact 5521 aacaaccagc tggtgttaat ttcctgctta cccttagagc gctcagaaat catataattt 5581 gcgtgatcat tgttagtttt gtttaattgt tttgtttctg ggtttgtgtg tgtgtgtgtg 5641 tgtgtgtata tatatctgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtg 5701 tgtgtgtgtg ttttggtcct ttcccctatc ggatttgacc aattctgaac cttcaagctc 5761 atgagtgtga aattttccac tctgaagaaa cagaacacat tgctcccctc agccctttgg 5821 ggcattctca ggcgactgag aatcacatga gggtttctgg gagaaatgct ccctaagaca 5881 tgcagcagct ctaaataggt ttccccctca aaagaacata cttagggtct aatctcagcc 5991 agcagatgca tataaggaac tgacccctcc caaactttga gcccctgaca cactgtgcca 6061 ggtggccaca acgctggtgg accaaactgg ttcagggtgt aatggccctg tgaaaagcta ggtttgcaag cagcacattt tgggtccaac acacatccca acttggtcaa atccaaaggg 6121 gaactctaaa ttatagagaa caaggcctct aagaccccag cagttgcaga atataaagtt 6181 cccctcttag aaactccagc agggtatatg caaaatactt atggtgaatc atcatgcaaa 6291 tatttaacca agcggaccac tataactaaa gcagattcta agttacaatg gcctaaatgg 6301 ggatcttttg agatgcccaa attagtgtac ctgtgaacca ggatggagaa tgcagacaca 6361 aaaaccaaac aaccagaatg ggacagctat tttcagtggt agctgcaaag tagcaaaagt 6421 ggggaagacc actgtcacgc gtgtctgggt gaagtgacca ccaaacaggc tttgtgtgtg 6481 caacaaggct gtttatttca cctgggtgca ggtgggctga gtccgaaaaa gatgtcagca 6591 aagggagtta ggggtggggc agttttatag gatttgagta ggtagtgtca ggaggcccga 6601 cactcctgtc ttcttatatt aataagaaaa acaaaacaag atagtggcga agtgttgggg 6661 tggcaaaaat tttggggggt ggtatagaga gataatgggc aatgtttctc agggctgctt 6721 cgagcaggat taggggcagc gtgggaacct agagtgggag agattaagct gaaggaagat 6781 tttgtggtaa ggggtgatat tgtggggttg ttagaagcaa tatttgttgt acagaatgat 6841 tggtgatggc ctggatacag ttttgtatga attgagaaac taaacagaag acacaaggtc 6901 cgaataagag aaggagaaaa acaggtatta aaggactaag aattgggagg acccaggaca 6961 tctaattaga gtgcctaagg gggttcagcg tgattattgc ttggttggtc agttttgggg 7021 ctctatcctt gagttttttt atgttgtcac ataccaggcc agattgattt aggtgaaaac 7081 aacactcttc atttaaaaat atagagtccc ctttttttaa gcagtgagta agcggaagtc 7141 tcggtgattt tggaggaaat agaaatgcaa agccagcaat tgtttgttaa agaaggatta 7201 gaaacggcta ggagagagtg agattgatag tgtggtggag atagctgggg agaggtagag 7261 ggtggcataa gaatgggaac gagaataaga gtgagtaaaa aagtaaagaa taggacttca 7321 tcagggtgaa agtaccggac tgtgccttgc cactgaagat cttttatcca cttcaagaga 7381 gatttaaggg tggtggtttg agataaaacc aggagatacc agttatgatg gtttggagga 7441 aaagtgtaaa ctgggagtgt aaacaagggc agggcattta tgagtagttg agaatggtga 7501 ataggagtat gactagacag aagatagtag ggatgacaag tttttggggt gcagtccaag 7561 ttgggctggt gtctggaatg agactggggc ctaataaaaa ggagtgtcca tacaggagct 7621 caaatgggct gtaccctgta gcatcccgag gacaggccca aattctgaga agggcaagtg 7681 gtaaaagtat tgtccagtcc tttttaagtt ggaggctgag cttggtgagg tgtgttttta 7741 aaagaccatt agtccatttt acctttcctg aagattgagg atgggaaggg gtatgaaggt 7801 tccactgaat accaggagcc tgagaaactg cttgggtgat ttgactaata aaggccggtc 7861 cgttatcaga ctgtatagag gtgggaaggc caaaccgagg aattgtgtct gacagaaggg 7921 aagaaatgac cacagtggac ttctcagacc ctgtgggaaa tgtctctacc catccagtga 7981 aagtgtctac ccagaccaag aggtatttta gtttcctgac tcagggcatg tgagtaaagt 8041 caatttgcca gtcctgggca ggggcaaatc cctgagcttg atgtgtaggg aagggagggg 8101 gcctgaacaa tccctgagaa gtagtagaat agcagatgga acactgagaa gtgatttcct 8161 tgaggataga gttccacgat agaaaggaaa tgagaggttc taagaggcgg gctagcagct 8221 tgtaacctac atggaagaag ttatgaaatg atgacagaat agaatgggcc tgtaaggctg 8281 gaagcaaata ttttccttgg tccaagaacc atttgccttg tgtgggaaga gattgatagg 8341 tggaagtttc agcgggggag taggtgggag tgaccaatga aaaggagaaa aactggcagt 8401 gagggacaga agttggaatg ctagctgctt ttttagttat cttattagca taagtgttgc 8961 cttgagcgat gggatctgat gccttttgat ggcccttgca gtgaatgact agcttttttg 8521 gaagtagagc agctttaaga agagttttta ttaaggaggc attaattatg gaggaccttt 8581 gtgtagtggg gaaacttttt tctgctcata taacagcatg gtagtgcagg atatggaagg 8641 catatttaaa gtcagtataa atattaacac atagtccctt tgcaagagtg agggcctgag 8701 ttaaggcaat gagtttggct tgctgagagg tagtggaggg gggcagagca gtagcctcaa 8761 ggatagatgt ggaagacact atagcttagc ctgcctttgc cagtgattgg cgattaggcc 8821 tggtggaact gccatcaagt gtgatcaggg tgaagaacag gaaagaagga aatatgggga 8881 aatggagtga atgccaggtg gatcagagag atacagtcat gggggtcaga tgtggtatca 8941 ggaataatgt gggaggccgg attgaagtcc aggccaggaa caacggtaac tgtgggagac 9001 tcaagaaaga gtaagtacag ctgaaggagc cagggggcag gaagtgtgag gaggaaaata 9061 gattttgaaa gttatgggaa ctgtagaggg ttagtggagc atagcttgtg atttttaggg 9121 cctctaaaag tattaaagcg gcagcaatga ggtgtggctg tagcctagga atagtcaggg 9181 aagcggataa tttagttaaa atgtctcaat ctaataaggg agctgggcag gtggggataa 9241 ctaaaaaaga gtgcataaaa gaatgttgtc caagttggca ccagagttgg ggagttttaa 9301 ggggtttaga agccttgctg tcaataccca caacagttat ggaggcaagg gaaacagtcc 9361 cttaaaaaga aggtaatgtg gagtgggtag cctccatatt gattaagaag gggacggact 9421 taccctccac tgtaagagtt acccaaagtg tctgtgatgg tccaggaggt ttccgaggcg 9481 attaggcaat gtcagtcttc aactgctaag ccacgaatat ctgggaagga gtcagtcaga 9541 gagccttggg ccagagttcc aggggatctg ggagtggctg ccaggcgagt tggacagtcc 9601 aatttccagt ggggtcccgc acagatggga catggcttag gaggaatccc gggctgcggg 9661 cattccttgg cccagtggcc agatttccgg cacttgaagc aagatcctgg gggtggcagt 9721 cctggaggaa cgcctggctg ctgcagttca ggtgttttga agttcttgtg tgctggagat 9781 gtggctgggg tttctctcac agtggaggca agtaattgca actcagaaat acgttgctac 9841 ttggctgcct ctactccatt attgtccaca ttgaaggaga ggttaattaa gtcctgttgt 9901 ggggtttgag ggccggaatc taatttttgg agctttttct aatgtcagga gcaggttggg 9961 taataaaatg catattgaga ataagatggc tttctggccc ttctgggtct agggcagtaa 10021 agcatctaag ggttgttgcc aaacgggaca tgaactaggc tggattttta tatttgatga 10081 aaaagagcct aaccactaac tgatttggga gaggtcagat aaagaaaaag gagaattaac 10141 cttggctatg ccttcagctc cagccacctc tttaagagga aattgttggg caggtcgggg 10201 agggctagtc acagaacaaa actataagct ggaccaggtg tgaggagggg aggtgataaa 10261 aggattatag ggtgggagag cagaggctga ggaagaattg ggacctggct cggcgtggca 10321.aggagcagcc tggggaggag gggagaggtc agataggtcc gtagaaaagg aggattcaaa 10381 ggactcagag cttgggatgg agactgaagg aacaggagag aaagaagaaa gatttgggac 10441 aagtcgcact gggagcagag actaaggagg gatcaatgtg taaaagaatg cctggacgtc 10501 aggcacctca gacccatttg cccatttttt gaccaaaatc atccaggtct tgtaaaatgg 10561 agaaatcaaa agtgccgttt tctggctatt tagaaccatt attgagtttg tattggggcc 10621 aagcagtgtt gcagaagaaa ataagacgct taggttttag gtcaggcgag agttgaagag 10681 gttttaagtt tttgagaaca caggctaagg gataagaaga gggaatggag ggtggaaggt 10741 tgcccatagt gaagaaggca agccccgaga aaatagaggg tagagacatg gagaaggggg 10801 gtggtgagca gccctgggct gcaatgtggg cgagcagcca cagccaaagc aggcgtccct 10861 gcaattgact tgccaccaag ggaatgtggg tgaatgacca aggtaggcat ccctgcggtg 10921 atcagacacc aatggagtgt gggtgaataa tcaggcaggt gtccccgcag tgattaaaca 10981 ccaagggaag actgtct~cc tgagttcatg actggcgccg gagttctggg tccatggata 11041 aaatgtgtct cctttgtctc tactagagag gaaaaagaac tagaattgga aggacagaga 11101 gattgaaggg tagcgagaga gggagactga agggtggcaa gagaggctgg agaagagagt 11161 aaaaagacca cttacccgat ttgaaattgg tgagatgttc cttgggctgg ttggtctgag 11221 gacccgaggt cataggtgga tctcctcatg gagtgagggc gaggacaggg gactggtctc 11281 ccaaaggagt cctcctgtcc cgggtcttcg gcaccaaatg tcacactcgt ccgtgtgaag 11341 agaccaccaa acaggctttg tgtgagcaac aaggctgttt atttcacctg ggcgcagttg 11901 ggctgagtcc gaaaaaggag tcagcaaagg gagttagggg tggggcagtt ttataggatt 11461 taggtaggta gtggaaaatt acagtcaaag ggggttgttc tcttgcgggc aggggctggg 11521 gtcacaaggt gctcggtggg ggagcttctg agctaggaca tttcacaagg taatgtaatc 11581 agttaaggca ggaacaggcc attttcactt cttttgtgat tcttcagttg cttcaggcca 11691 tctggatata tacgtgcagg cttgggctca gaggcctgac aaccacctca tctccctaca 11701 ggaggccaac aaacaactta gaaatgctaa ccaagaactc tgtaatcttg tatctctctt 11761 aaagaaatcc tcagaattcc ttacttcccc cttggtacct ccccctacac ccctactcta 11821 ccctgaccaa tctgaacttc ctggaccaga tctgtccgcc gcctctactg catgtctaac 11881 acttgctcaa cagaaggcag ttcagagtct gactgcaaag accccacccc ctcatgattc 11941 cctgacagct ccaatggcaa catctcatct ggaagatgtg gaaaaggggg accgtgcagg 12001 gatatctctc atgatcaccc tattttggga acaactgcta acaggtaggg gaaccctggt 12061 aattgtctac caacaccctg gtcaaaggct gaattccaag gcataaagaa tttcctgacc 12121 cccataaaga tccaattggg tttgagtatt tgagctcatt gtcagaacct atgacccagg 12181 tcattcagac ttttatcagc tagtccacat gttggtctca gaagctaaag ctaaggaatg 12241 gctgggaaaa gcacaatggt cagactctat agcagatttg acccctgaag gcccaatgga 12301 gccacaacaa ccagccccca caaatccaga agacaggcac aaagatgtgc aggaatgagc 12361 aaccactcta ttaaatatca ttccttcagt gttccaaagg gttgtggatt ggaataaaat 12421 ccaacaatgt caccagaacc caaataaatt agttttagat tatttaacac attttgataa 12981 aactttaaaa caacattgtg ggatgtcagc tgattgcttt gaaaacaata aaaatgatac 12591 attattaaat gcaaatttct taaacggact agatgatgat ttagccaccc ttgtaaaaca 12601 caaattggac cacagccaga actaatgaac tagttaactt agctgaccaa ttatcccgca 12661 ctatgataaa acaaggaaaa acagaagatt gcccaagtta tgcatttaca gctaaagcaa 12721 ttaacttctc aagcctctcg gccccagaaa gattttaagc tccctcggtc tgaggactct 12781 tccctcccag tctgttacaa ctgtaaatga ccgagacacc ttatgatgga ttgccttagg 12841 ctgaaacaaa agaaaaggca gaatgcaact caggaagaca aggggtgctc caaggaaata 12901 caggggtttc acctctccaa atattctacc ctgacaaacc aattggggga gattaatata 12961 ataataaacc atgagtttac aactgcctta actgacatag gtgtgactat ctctgaaaaa 13021 tcccacctta tttagaaacc ccattcctca gagtaatgaa agaatgaaca tggtgggtat 13081 gtctaataaa atgatctcat gttttaagtc caaacccgta ccttagggtt catcaggttc 13141 cactaccctg tcgcaggctc taagtgtgac acactcagta ggtcccatat gtttctaata 13201 tgcactgggg cccctgtcaa acttttgggc tgtgatctca acatccataa tgcccatatc 13261 tctttttcat caaaaggtga aactttttta gaattggagc caggagacca aaaataccat 13321 atttaaaaat gtcctgacaa cgtacaattt agtactagta atgttaaaat gtcatcttgt 13381 gaccaggaaa ataaaataga gacagagaag gaaatattag ggaagaagag agaacattgg 13941 aatacagagc aggaaacagt aaaactcctt ttagtttccc cagtcttcct gttaacacca 13501 gaagcagagc acttgctcaa ggatgtgtcc tcccacttat agtctcagtc aaatacagat 13561 acagagaaag tattctcagc cattccaata aaggtagaga taaatccaaa gaaaccccta 13621 tccaacctta aacactatcc tctgcaaaag gaagccatag atggaattgc tcctgtcata 13681 caagattatc tgagaaacgg gctcattatt ccctgcacaa tcccctgaaa cagccctata 13791 ttccctgtaa agaaactaag cgggagagga tggaaatttg tgcaggaatt gagggcaata 13801 aacaatatca taattctcag gcacacagta gtccccaacc cacaaaccct tctatcacct 13861 atatccacta ccagccagta tttctcagtt gtggatctct gcagtgcctt ctttagtatt 13921 cctgtagaac cagacagcca atatttgttt gtctttattt ggaaagaatg gcaatatacg 13981 tggactataa tgccccaaag gtatacagaa agtcccactt agtgttccca aatattagaa 14041 gctgatttgg agaattaaat attttcccag ggctcaacat tcatctactc tcctttgttc 19101 agacacactc tcttcctctc aggaagatag tctatattta ctcaaacagc caccaaggga 14161 cacaaatgtc taaagacaaa cttcagctat gcttacctga agttaagtat ttgggacata 19221 ttatctcagc caaaggactg agtattaacc ctgatagagt gaggaatttt agctttccca 14281 atgcccgtca ctaagaaaca acttagagta ttttggggcc tggcaggcta ttgtagaaac 14341 tggataccaa atttctccct tatggctcaa cttcagtgta catacctaaa aaatgaacaa 14401 cctgatccca tcatgtggac tccggaggga caatcagctg tacaacaaat aaaggaaatt 19961 ctgactaatg ccccagcctt agggcacccg aactacaaat tgcctttctc ccttttcata 14521 cacgaagttg gaggtactgc atccggagta ctgacccaga aacatggtga tcatcagaga 19581 cctataggct attatagcca acagctggac cctgtggctc aagggctgcc tccctatgtg 14691 agagcaatag cagccacggc ccttccgtat aagtctgttg aagaaataat tataggttcc 14701 ccccttaaca tttttgtgcc acattctctt gagacccttc taaactctca tcatacacaa 14761 cacctgtctg tcaactggtt agcctcttat gaaattttgc ttttatcatc tcccaatatt 19821 actagttcct gctgtaataa tcttaatctg gccactctct tgccaggccc ttctgacaaa 19881 accccctcat gactgtgttt tgatgactga cttctcaccc ccaggacaga cctacaagag 14941 atgccactgg ataatgctga gatagaatgg tatacagatg gatcttattt aagaggagag 15001 gatggaaatt ttatagcagg atatgctgtg gtttccttac tagaggtaat tgaagccaat 15061 cctctccccc aagccagatc agctcaagtg accaaattgg ttgccctgac cgaagcttgt 15121 caattggcaa aagacaaggc tgcaaacatt tacactgaca gccactatgc ttttggggtt 15181 gctcatgact gggatgttat ggaaagagag aggatattta accccctcag ggcaacccat 15241 aaaaaatgga caagtatcag agttgttaga agctgttcta acaccaaaac gcttggcaat 15301 tataaaaatc ccaggttggc caggcgcagt ggctcacgcc tgtaatccca gcactttggg 15361 aggccgaggc aggaggatca cgaggtcagg agatcgagac catcctggct aacatggcga 15921 aaccccgtct ctactaaaaa tacaaacccc gtctctacta aaaatacaaa aagttagccg EPl-109 907 15981 ggcgtggtgg tgggcgcttg tagtcccagc tactcgggag gctgagg~ag gagaatggca 15541 tgaacctggg aggcagagct tgcagtgagc cgagatggcg ccactgcact ccagcctggg 15601 caacagagag agactccgtc tcaaaaataa ataaataaaa ttaaaaaaaa atcccaggtc 15661 actcaaaatt agacaccaca gtaagtcagg gtaaccaatt tgctgaagcc acagctaaaa 15721 gagcagcatt caagccatca gccccaagtt ggaaaatggc cataaaaccc aaaacactta 15781 aatacatgtt gaaagaaacc cagagcatag ctcctacaaa agagaaatct acttggaaac 15891 aggcaggggg atacttgtct cccaaaactg aaatatggtg tggacctaat tattccattc 15901 caagaaaccc attattccaa tggaatgtca ggtgtccctt atgaaatatg ttcataatct 15961 aacccattgg aatccagata aaataatatc ctggtgtaaa caatattact ggaaaccatc 16021 cttcacagtg gcacaaaaag tttactctca gccgggcacc atggctcaca cctgtaatcc 16081 cagcactttg ggaggcccag gcaggtagat cacctgaggt caggagttca agaccagcct 16191 ggctaacatg gcaaaaccct gtatctacta aaaatacaaa aattagccag gcatggtggt 16201 gcgtgcctgt aatcctgctt cttgggaggc tgaggcagaa gaatcgcctg aacccaggag 16261 gcagaggttg cagtgagctg agatcacgcc attgcactct agcctgggcg acaagagcga 16321 aactccatct caaaaaacca aacaaaaaag tttactctca atgtgttatc tgtcccaaac 16381 ataacccagg aaaacccctc catggggccc agggtcattt tccccttccg gctgaccttt 16441 tgaggtatga cagcttgatt ttatccagct gccatcatct caatgttaca agtatgtttt 16501 agtaatggtc tgcatgtttt atcattgggt tgaagctttt ccctgcaggc aagcaacagc 16561 cacgacagtt ggaaaaatcc tactagaaaa aattgtccca ctgtggggag tcccctgtga 16621 acttcacagt gatgggggat catactttac tggccaggtt actcaaaata tttgtaaaat 16681 ttggcccata tttcaacatt tccattgtgc caccatcccc agtcttcagg cctggtggag 16791 aggaccaatg gaataattaa aacacaattg gctaagttca cagaggcatt tcacctcccc 16801 tggcccaaag cactacccct agtgctgctt atactacgat ccactccttt tggaaaacat 16861 caactgtctc cttatgaaat tataacagga aggcccatgt gtatgggaac gaacataacc 16921 aatccaactt ttctccaggg agatatattg caatattgtg agggactcat ttatcatctt 16981 agaaaaaacc aaaatttgtt aaaaaattcc tttcacggtg cgctccccga agataaggtg 17041 cctggtcatc tgcaacctgg agatttcatc tattggaaaa gacatctaat aaaggattcc 17101 cttcaaccct gatggaaggg cccgtaccag gcactactga ctaatccatg tactgcaaaa 17161 ttaaagagta tagattcatg gattcacatc tctcatctta aaaaggcaca acctcctgag 17221 tggactgtaa ctcccaccaa agaccttcac ctccggttca ctaaacatca acctgcaacc 17281 caggattaga agcagacaac agctgttgtg gactgcttaa acccaagaca cagaaccagg 17341 cctgtataca aagggaacgc ctctgtttat tgtacagtaa ccattacaat tattgtccta 17901 gatataccgg caactgctgt cttataaatg acagggcact tgccttgtct gatttaacac 17461 catttagtaa ctaaaatgaa tttcgcaacc ttgctattat taatcctata tccctacact 17521 ttcttgccac tgccacccac tgatgcccat gaaacaaacc tgtttctaca atgggctcag 17581 cattatgcag acaaattaca aagaacacct gctggatatg cagactcatg cctctttcca 17641 gtggctccag cctgccatgg tggatatccc ccttccaagg tcaggactgg atagaatacc 17701 aaaaatttat cacatcacag aaatggtctg gtattcttag tgctgggata acaaaagaca 17761 atacatacaa ttqgcccatt aaaaacactc ttaagaacaa gggacatggg aaaagatttt 17821 gaatggaaag gaccaggtca ttagctctca ctttagcatc cccccagcta aaacagaagg 17881 tggtaaccac accccaaaca acagctcatt ttcaaaatgg aataatgcaa atttgggctg 17941 gatttatctg gctcacccgt tcgtctggcc aactcagcca aaattctcct ctgtgctggg 18001 agaaagaaac catatcaagg acctatggcc aaacagtacg agagatacgg ggtggacacc 18061 tggagaatgc tgtgaccaca ttatcatatt acaagacgct gactggaatg ccaccgattg 18121 ggtgcagcaa tcaggtattt attggatagc tccaaatggg acatattggc tatgtggcac 18181 taacttatgg ccgtggttac ctctagggta gttaggatga tgttccctag gttatgcttg 18291 ggcacaagac acgtaatcca gaccctgcca aaaccagcaa acctttttca tttacaattt 18301 cattggacat gttaggtatt ccaatggtat gatcacttag ctttaatctt tgtaccacag 18361 acaggtattg aagatgttat atggcatata gaggccttac ccaattacat ccaaaaggcc 18421 ctgaatgata gccacatgag tattgccttg ctaagcaatg aggtcatgct tatgaggaaa 18481 gttgtgctat acaaccatat ggctttagat atactcattg cagcacaagg ggggacctgt 18591 gccgtcataa aaactgaatg ttgtgtgtat attcagatga attgaagaac ataactcgat 18601 ttatgactga tatgaaaacc cagataacca acctgtcaga tctaaaaccc tcactaatca 18661 attggttgag tagttggttt ggatcctggg gaacttggtg gcagaagcta ctgcttataa 18721 taggaataat aataatttgt gttctgtcct gtttctgcta caatgttgtt acggtatgtg 18781 cttgcaaata agttaatgca caactgaaag ggctggggta ataattgccc agagaattgc 18841 tttaattgag gaagcagtaa tatagcttga cccagcttca aggtttgctt tccttttgtt 18901 gctataaata tgacctaggt ccctatatat atattttttt ctttttcttt tttcctttcc 18961 tttttccttt tttcctctcc cttttttttt taaatattcg tgggacacaa tttcctagga 19021 atgagccttc ctagcgacaa tgggcgtgac ttcctaggaa tgagccttcc tggtgatgtg 19081 ggacctaaac ttctagaaat aaactatcct agcaacagga aaccagttca gaaaagggag 19141 gaaaaatcaa cctgtagcca agaacccata ttccttttaa aatgcttcct tcaaaagatt 19201 ttaaataaaa aaagagggga aacctgaaag gaaattaaat tttgggaccc cccaaactca 19261 tttagcaaaa ggcaaaagtc aaaatgggaa ctgggtcatc caaacctgcc tccccctttt 19321,ggttcctcaa taaaattgtt acaagatgaa aagctacatg tctcctccat attttgccca 19381 cagagaaatt tctagtgagt tgttaaaatt tcaccatggc aatgcaaatc gatagcttat 19941 ctttacaggt gcagtcgccc ctqgcccacc agacataaat gcatatctga gtgttcccct 19501 gcccaatttt gtctatgtta tcttatgtaa aatgcagatt ccccagattt ttcctctgcc 19561 ccttttatgt catcttttat ttatttattt atttatttat ttatttactt atttattttg 19621 agatggagtt tcgctcttgt tgcccaggct ggagtgcaat ggcacgatct cggctcacag 19681 caacctccgc ctcctgggtt caagcaattc tcctgcctca gcctccagag tagctgggat 19741 tacaggcatg caccaccaat cccagctaat ttttgtattt ttagtagaga tggggtttct 19801 ccatgttggt caggctggtc tcgaactcca gacctcaggt gatccacccg cctcggcctc 19861 ccaaagtgct gggattacag gcgtgagcca ccacgcctgg cctttttgtt gttatttagt 19921 tttatttcat atcataaact taactctgca atccagctag acatggaaag gaacaaggaa EPI-109 ~8 19981 aacatggaac ccaaagggaa ctgcaatgag agcacaaaga ttataggcta ttgccagcaa 20091 atggggtgga ggggtgctct cctgagctac agaaggaatg gtctggtggt taagataaaa 20101 cacaagtcaa actttaataa gttgtccata gtcagcaatg gtgatcttct tgctggtctt 20161 gccattcctg gacccaaagc attccatggc ccccacaata tttatgcctt cttttacctt~
20221 gccaaagacc acatgtttgt catccactca gtcttggcag tgcagatgaa aaactgggaa 20341 ctgtttgtgt ccagcatttg ccatggacaa gatgccagga cctgtatgct ttaggatgaa gttcttgtca tcaaatttct ccctgtagat ggacttgcca ccagtgccat tatggcaatg 20401 tgaagtcacc accctgacac ataaaccctg gaataagtct gtgaacgcag gaacccttat 20961 aaccaaatcc tttctctcca gtgtgcacag catgaaattt ttctggtgtc ttggaaactt 20521 gtctgcaaac agcttgaagg agatgtggcc caagagccca ccatctatgg tgatgttgaa 20581 gaacaaggtg gggttgacca tggctgatag tacggggctc ctggcagcag cagcatctgt 20641 gaagtggcca ttctatgtta tcttatattt aaaaaatgca gatttgctga accagacaaa 20701 ggcatgaatg actatttttc cctaccccct cttacatgaa aattgtttac ttctcaatat 20761 cctacccttt cccctttaaa tttgaagccc tcaaaatcac cttcggagaa aggcatagac 20821 ctgtctcctg ggcacgtcct taactttggc aaataaatct aaaatcattg ggacttattt 20881 catcattttt ctcaattgac aaaacattta aaaaataata cagactggac ccagcctgcc 20941 caactcccag tggagagcaa ggtttccttc tattttcata ggcaaccaga acaatgttct 21001 atgcacattt tgtcctcagt aagagggcct ctggccaaaa tttggctagc ggcccattgg 21061 gataagaagc taaccaaagc ccctgtgtta cagtgtaatt tagagagcag catggagagt 21121 atcatctcac caaaggtgaa gatagcatta cggacatcag gacatctctt actgggagta 21181 gtttgaatct atcacaggaa agccaaatat cttcttgcag actgtaatga agcattcatt 21241 aagataaaga tggctttttg atcaggtgtt gacctgcctg aggaaaatca ggaagcagct 21301 tataacacca ttactttact tgaataattt catgactttg atcagccact gcctgactta 21361 gatgacatcg atgtggccca gaagttcagc ctgggtcaga gtagagtgga agaaataacc 21921 gtgagagaag aagttgggaa tatcagtatt ttacaagaaa atggttttgg cgattttgga 21981 atggatgatc attgagatca gagaaagcag tgcttttgag gatgatgaca tgttagtagg 21541 cactactgct tctaatctcc tattagagtc tgaacagagc accagcaatc tgaatgagaa 21601 aattaaccat ttagaatatg aagaccaata taaagataat aattttggag aaggaaatga 21661 tggtggaata ttagaagaca aacttattag taataatgat ggtagtatct ttgatgatcc 21721 ccctgccctc tctgaggcag aggtaatgtt gccagagcag cctgcacatg atgatatacg 21781 ggtgaggatg ataatacatc aatgggtggg cctgatagtc ctgattcagt gaatcctgtt 21841 gaaccagcca actatgactg atcaaacaac acttgttcca aatgaggaag aagcatttgc 21901 attggaacct attgatataa ctgttaaaga aacaaacgcc aagaggaaga ggaagctaat 21961 tgttgacagt gtcaaaaact tggatagcaa gacaattaga gcccagctta atgattattc 22021 tgatattgtt actactttgg atctggcacc acccaccaag aaataggtga tgtggaaaga 22081 gacaggagta gtagaaaaac tgttttcttt acctgctcag cctttgtgga ataacagact 22191 actgacgctc tttacatgct gtcttacacc acttgtacca gaagacctta gaaaaagggg 22201 gaaaggaggg acagataatt tggatgagtt cctcaaagaa cttgaaaatc cagaggttcc 22261 tagagagaac tagcaacagc tacaccagca gcatgatgtt attgataagc ccattttgga 22321 agagccaagc catctccaga agtcagtgat gaggccagca gaacaaatct ggatgagtca 22381 gctatgcctc caccaccacc tcagggagtt aagtgaaaag ctggacaaat taacccagag 22991 cctgtgatgc ctcctcagca ggttgagcag atggaaatac tgcctgtaga gcttccccaa 22501 gaagaacctc caaatatctg tcagctaata ccagagttag aacttctgcc agaaaaagag 22561 aatgagaaag aaaaggggaa aaaaagatga tgaaggggaa aaggatgaag atgtttcagg 22621 gggtgatcaa gatcaggaag aaagaagatg gaagaaaagg actcagcaga tgcttcacgg 22681 tcttcagtga gctcttgcta aaactggagc tgaatctatc agtttgcttg agttatatca 22741 aaacacaaac agaaaacaaa ctgttgcaaa gttctacagc ttcttggttc ttaaaaagca 22801 gcaagctatt gagctgacac aggaagaact gtacagtaac atcatcgcaa cacccgggcc 22861 aaagttccat attttatgag gagctagaag cattatagct agtgttcatt tcactagtgc 22921 ttacaaattg cccccatgtg taggagacac agaacccttt gagaaaactt agatttttgt 22981 ctgtacaaag tctttgcctt tttctttctc attttttccc agtatattaa atttgtcagt 23041 ttcatctttg agggaaactg attagatgga tgtgtttgtg ttctgatgga gaaaacagca 23101 ccctaaggac tcagaagatt aacagttcag aacagatgtg tgcaatattg gtgcatgcaa 23161 tgatgttgag tggcagttga aagtcatgat ttttatctta gttcttcatt actgcattga 23221 aaaggaaaac ctgtctggga aaatgcctga cagtttaatt taaaactatg gtatgagtct 23281 ttgaaaagaa aaaaaaaaag cctttccatc agtagtaaca ctggcaatct tcttgttaac 23341 cactctcctt agggatggta cctgaaataa caaaggtcac cctcttgaga ttcgttttaa 23401 gtgtaattcc ctaatgagca aacgtgtacg tgaaattgtg ttgtgactga tacccttcag 23461 ctacagatag gactgacttg gtttaaagtg ttctattttg taaatcattc catttgagtc 23521 tttctgatga acttcgctat ctcgaaatct gtcattttag tgaggctcca aaatgagcag 23581 aaataggcct gattagagta gagtgactat caaatagcag actttctagg acctataaat 23641 agaagtttta aaaagatgtt tggatatatt tgactattca gatcatgaaa acagaaatta 23701 ccctgcctac tacaaggaca gactgatggg aaattataca ccaggtcaac ttaaccttta 23761 agcagacaat gctgtaaaaa ctaatggctt ctctgatatt tattgtaagt tttagtactg 2382.1 atctcctttt ccagtgctgc acactcctgt gtttggaact ttaatagctt tgcaacgaaa 23881 tcctatatcc ggtttcctat aatttaactg aagaaaaaca catccaaata aaggtctata 23991 ttaacagacc agatagcatc agaaatcatg tgactattat gattatcaga atatgtctta 29001 actttttagg gcaaaattaa cactgaaagt tctagcttaa gtgttgacac tttcgtgggg 24061 aaaaaaatca cttttgaaac agacttcagt gtatactcaa taatttaaaa ttatgtgaaa 24121 tgttttaaat ttgtgaactc attactgttt taatgattcc gtttcttgag agtttaacca 24181 taaaaaattg ctattgcaga tttattttca atatgctgtg cctgtaaacc atggagtttt 24241 ccctgtttgt aaaaagacat tgtagataat tgaatgtttg attttagaaa ggtcattggt 29301 ttcttgttac acattttgtt agtctgtttt ttttgcttat tgggtttaat attgttcttg 24361 aaaatagttg atgctatgtt atgtataact cttctaataa aagttgtgtt ataagttgaa 24421 acaaattata gtattacaga ctggctacaa taactttata ggaagtctga aaaatactca 29981 aagttctata gcaaccaagc aaacacctag tcaagaaaac gatacagtca aaatggttag 29541 aaattttgtg acatttttac ttgcctgtac cccatccttc cctcctggca cacctgggga 29601 agcagcagcc ctgctcccaa ttccctccct ggaaccccag agagaggaaa gtggacttta 24661 tttgcaacat tctaacctgt caaggggctg cctgaggtac tggtctctgt tttacctaat 29721 tcggaggtca gacagggaaa agcaacatgg ctggatactc aggctcagga aaagccacag 29781 gaaatgatgg gcactactca tgaacactgc agggggccta caaactcaca gatacctgga 24891 gcaagagatc agaagtagaa gaatacaata gaacatctaa gcccaccttc tgagaagcag 24901 aggtgagact ctttaggaaa ttgagacatt ttaagcagtc atgcattcaa gggaactgga 24961 aaacaacaac aacaacaaca acaacagata cccaggccaa ggcaaaatgc atagccaaaa 25021 gaggtctaag aagaccttaa gacctcacat ggggctgatc ccaaagctga cagcatgccc 25081 tgctaattag tgaaggtctt ccctggcaca gaacctactt gtaatgacta gcagaggtgg 25191 ctgttttttt gaatgatcaa ttttaaaaat gaacaaaaaa ataacaaacc atgcaaagaa 25201 acaggaaaat atggcccatt caaaggaaga taataaactg tcagaaactg tccctgaaga 25261 aacacaagca tcagaagtac tagacaaaga caaaatgtct taaatatgct caaagagcta 25321 aatgaaaact caaagaacta aaggaaatga gaaaaatgac acataaacaa aagagaatat 25381 taacaaagag aaactataaa aaggaaccaa acagaaattc tggagctgaa aatacagtat 25491 ctgaattgaa aaacgcctag agggattcaa cagtagattc aaacaggaag aaaaaagaat 25501 cagtgaactt gaagataagt cctttgaaat tattgaatct gaagaccaaa taataataat 25561 aataattaag aaaagtggac agagactaag agacctatgg gataccatca agctaaccaa 25621 tatatgcatt acagaaatct cagatggtga cgggataaag aaaggagcag aggaactatt 25681 tgaaaaaata atggctgaaa acttcccaaa tttgaggaaa ggcattgatt cacaaatcca 25791 aaaatcttgc tgatctccag gtaggataaa cccaaagcag tacataccaa gacacattat 25801 attctaacaa aagccaaaga catggaacac tgcaggggga ctacagactc acagaaaccg 25861 ggggcaagag atcagaggta aaggaataca atacaaagtc taaggccccc tcaagaatct 25921 tgaaagaagc aagagaaaag taactcatca tgcacaatgg atcttcaata acattatcag 25981 tggatttctc agcaaaaacc ttgaaggaca caaggaattg aataccatat ttaaaggaaa 26091 ttttttaatt gttatttttc cataagttat tggagttcag gtggtatttg gttacgagta 26101 agttatttaa tggtgatttg tgagattttg gtgacctgtc accgaagcag tatacactgc 26161 actgtatttg tagtctttca tccctcaccc acctcccact cttccctcca agtccccaaa 26221 gtccattgta tcattcttat gcttttgtgt cctcatagct tagctcccgc atatcagtga 26281 gaacacgtga tgcttggttt tccattcctg agttacttca cttagaataa tagtctccaa 26341 tctcatccag gtcactgcaa atgctgctaa ttcattcctt tttatggctg cacagtattc 26901 catcatatat atataccaca gtttctttat ccacttgttg attgctgggc atttgggttg 26461 gttccatgat tttgcaattg tgaattgtgc cgctataaac atacatatgc aagttatctt 26521 ttttgaataa tgacttcttt tcctctgggt agacacccag tagtgggatt gctggatcaa 26581 atggtagttc acttttagtt ctttaaggaa tctccacact attttccata gtggctgtag 26641 tagtttactt tccaccagca gtgtggaagt gttccctgtt taccacatcc acaccaacgt 26701 ctactgtttt ttttattatg gccattcttg caggagtaag gaggtattgc attgtggttt 26761 tgatttgcat ttccctgatc attagtgatg ttgagcattt tttcgccatt tgtgtatctt 26821 ttgagaattg tctattcatc tccttagtcc actttttgat gggattgtgg gtttttcttt 26881 cttattgatt tgtttgagtt cgttgtagat tctggatatt agtcctttgt cagatgtata 26941 gattctgaag cttttctccc actctgtggg ttgtctgttt actctgctga ctgttccttt 27001 tctgtgcaaa agctctttag tttaattaga tcccagctat ttatcttttt attgcatttg 27061 cttttgggtt cttggtcatg aaatccttgc tgaagccaat gtctagaagg gtttttccaa 27121 tgttatcttc tagaattttt atagtttcag gtcttaggtt taagtcctta atccatcttg 27181 agttgatttt tgtataaggt gagagatgag gatccattgt cattctccta catgtggcta 27241 gccaattacc ccagcaccat ttgttgaaaa aggtgccctt ttcccacttt gtttttgttt 27301 gctttgttga agatcagttg gctctaagta tttgggttta tttctgggtt ctctattctg 27361 ttccattggt ctacgtgcct atttttatac cagtaccaca ttgttttggt gactatggcc 27421 ttatagtata gtttgaaatc agctagtgtg atgcctccac atttgtcctt tttgcttagt 27981 cttcctttgg ctatgcgggc tcttttttgg ttccatatga ttttgggaat tgttttttct 27591 aattctgtga agaatgatgg tggtattctg atagagattg cattgaattt gtagatggct 27601 tttggcagta tggtcatttt cacaatatta attctaccca tccatgagca tgggagatgt 27661 ttccatttgt ttgtgtcata tatgatttct tacagcagtg tttgtagttt tccttgtaaa 27721 ggtcttttaa ctcattggtt aggtatattc ttaagtgttt tttttttttt tttgcaacta 27781 ttgcaaaagg ggttgagttc ttgatttgat tctctgcttg gttgctgttg gtgtatagaa 27891 gagctactta tttgtgtaca ttaatcttgt atgcagaaat tttgctgaat tcttttatca 27901 gttctaggag ctttctggag gagtctttag gggtttcaag gtaaatgact gctatatata 27961 aagtttcagt ggcacaaaag aaatagcact caaatataaa attttctttt taattctcag 28021 caaggctagt tacttctcta tagaagggtg tgcccttaca gatggaacaa tggtgagcgc 28081 acacttggac gaggggaagg gattcttatc cctgacacac atggcccctg ctgctgttgt 28191 tcccctattg gctagggtca gaccgaacag actaaactaa ttccgaccag ctaatttaaa 28201 gagaatgacg gggtgagtgc tttggaggga gtcagggcag agcaggtagc aggtaaatgg 28261 aatgagttag ggtggagcag gtgattggaa tgtagggtgg agcaggtgat cagaatgagt 28321' cagggtggag taggtaaccg aaaaaggttg ctttacgagg aagttaagtt taaaagtaga 28381 aggcaaagaa ttgaacatac tgacatatta attcttcgaa aagaaattta gaactcatat 28941 ctaacatgat catatcatca gcaaacagtg acagtttgac ttcctcttta ccaattggat 28501 gccctttatt tctttctctt gtctgactgc tttggctagg acttccagta ctatgttgaa 28561 gaggagtggt gagagtgggc atgcttgtct tgttccagtt ctcagaggga atggtttcaa 28621 cttttcctca atcagtatta tgttggctgt gggtttgtca tagatggatt ttattacatt 28681 aaggtatgtc ccttgtatgc cgattttact cagagtttta atcatatagg aatgctgggt 28741 ttcgtcaaat gctttttctg catgtattgt gatgatcatg tgatttttgt ttttaattct 28801 gtttatgtgg tgtataacat ttattgactt gtgtaggtaa aaccatccct gcgtccctgg 28861 tacaaaactt acttgatcat ggtggattat ctttttgata tgttgttaga actggttagc 28921 tagtattttg ttgaggattt tagcatctgt gttcatcaaa aatattggtc tgtaattgtc EPI-109 910 _ 28981 ttttttggtt atgttctttg ctggttttgg tattaggatg atgctggctt catagaatga 29091 attagggagg gttccttctt tctctgtctt gtaaaatagt gtcaaaagga ttgataccaa 29101 ttctttgaat gtctgctaga agtctgctgt gaatccgtct ggtcctggac ttttttttgt 29161 tggtaatttt cttaattacc atttcaatct cactgcttgt tgttggtctg ttcagggtat~
29221 cttatccttc ctgatttaaa ctaggagggt tgtatttttc cacgaattta tccatctctt 29281 ctgggttttc tagtttatgt gcataaaggt attcatagca gccttgaatg atcttctgtt 29341 tctgtggtgt cagttgtaat atctcccatt tcatttcttt cctttttttt ttttttgaga 29401 tggagtctca ctctgtcccc caggctggag tgcagtggtg ccatctcagc tcactgcaac 29461 ctccactcct gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacgg 29521 gcacccacca ccacgcccag ctaatttttt ttctgttttt agtagagaca gggtttcact 29581 gtgttagcca ggatggtctc gatctcctga ccccatgatc cgcccacctc agcctcccaa 29641 agtgctggga ttacaggtgt gagccaccgc acccggccct ctcccgtctc atttcttact 29701 gagcttattt ggattttctc tcttctttac ttggttaatc ttgctaatgg tctatcaatt 29761 ttatttgtct ttcaaagaac cagcttttca tttcatttac cttctgtatt tttgttcatt 29821 tcaatttcac ttagttctgc tctgatcttg gtgatttcct ttcttctgct gggtttgggt 29881 ttggtttgtt cttgtttctc tagttccttg aggtgtgacc ttagattgtc tgtttgtgct 29991 ctttcagact ttttgatgta ggcgtttagg gctatgaact ttcctcttag cactgccttt 30001 gctgaatccc agaggttttg atagttgtgg cattattgtc attcagtttg aagagttttt 30061 aaatttccat cttgatttca tttttgaccc aatgctcatt ctggaccagg ttatttaact 30121 tccatgtatt tgcatggttt tgaaggttcc ctttgaagtt gatttccagt tttattccac 30181 tgtggtctga gagagtgttt gatataattt caattttctt aaatgtattg aagctcattt 30291 tatggcctat catatagtct atcttggaga aagttccatg tattgttgaa tagaatgttt 30301 tattctgcag ttgttggatg aaatgttctg tatatatctg ttaagtccaa ttgttccaac 30361 gtatagttta aatccattgt ttctttgttg actttctgcc ttgatgaact gtctatggct 30421 gtcagtggag taatgaagtc ctccatgatt attgtgttgc tatctatctc atttcttagg 30481 tgtattagta actgttttat taattttgga gttccagtgt taggtgccta tatgtttagg 30591 attgtgatat tttcctgttg gaaaggcctt ttaccattat atactgtccc tctttgtctt 30601 ttgtaactgc tattgcttca aagtttgttt tgtctaagaa tagctacccc tgctcgtttt 30661 tggtgtccat ttgcatgaaa tgcctttttc caccccttta ttttaagttt atgtgagtcc 30721 ttatgtgtta ggtgagtctc ctgaaggcag cagatagttg gttggtgagt tcttattcat 30781 tctgcagttc tgtatctttt aagcggagca tttagaccat ttatattcaa tgttaatatt 30891 gaaatgtgag gtactgttgc tttcatcatg ctctttgttg cttgtgtact ttggtttttg 30901 ttgtttttgc tttttaactt atatttttgt ttcataggtc ctctatgatt tatgctttaa 30961 agaagttctg tttttatgtg tttccaggat ttgtttcaag atttagagat ccttttagca 31021 gttcttgtaa tggtggtttc ctaatggcaa attctctcag catttgtttg tctgaaaatg 31081 actgtatctt tccttcatat atgatactta gtttctctgg atacaaaatt cttggctgat 31141 aattattttg tttgaggagg ctgaagatag gtccccggtc ccttcttgct tgtagggttt 31201 ctgttgagaa atctgctgct aatctgatag gctttccttt ataggtaacc tggtgcttct 31261 gtctcacagc tcttaagatt ctttccttgg tcttaagttt ggataacctg atgacaaagt 31321 gcctaggtga atatcttttt gcgatgaatt tcccaggtgt tctttgtgct tcttgtattt 31381 ggacatctag gtctctcgca aggccaggaa aggtttcctc gattattccc ttaaacatgt 31991 tttccaggct tttagaattc tcttctttct caggtacact gattattctt aagtttggtc 31501 atttaacata attccagatt tcttggaggc tttgttcata tttccttatt cttttttctt 31561 tgtctttgct ggatggggta attcatagac cttaaagctc tgaatttctt tattctactt 31621 gttcagttct attgctgaga ctttccagag aatttcacat ttctgaaagt gtgtccaaag 31681 tttcctgagt ttttgactgt ggtttcttta agctatctat ttccatgaat atttctccct 31741 tcacttcttg tatcattttt tgaacttcct tgtattgggc ttcgcctttc tctggtccct 31801 ccctgattag cttaataact aacctcctga attctttttc aggtaaacca ggtatttctt 31861 cttggtttgg atccattgct ggtgaagtac tgtaattttt ggggggtgtg gaagagcctt 31921 gtattgtcat attactgggt atctcagccg tggataccag cacctgttcc aatggaggtg 31981 gcggagggtg caatggactc cgtgagggtc tttagttttg gtgatttaat gctctatttt 32041 tgtgctggtt ggtctcctgc caggaagtgg tgctttccag aaagcatcag ctgtagtagc 32101 gtggagaggg actggtggtg tgcagggccc tagaactccc aagattatat gccctttgtt 32161 ttccactacg agggtggata aggaaggacc atcagatggg ggaagggcta ggcgtgtctg 32221 aactcagact ctccttgggt gggtcttgct aaggctgctg tggaggatgg gggtgagatt 32281 cccaggtcac tggagttgtg cacctaggag gattatggct gtctctgctg agtcatgcag 32341 gttgtcaggg aagtggggga aagccggcag tcacaggcct cacccagctc ccacacaaac 32401 tgaagggcag gtctcattcc caccgtgccc tgaccaacag ccccaagtct gtttccatgc 32461 ggagagtgag aagggcttga aaacttgctc aaggctatct gcctcccagc tgtgagagaa 32521 aagggcttta attcttctcc ctgcctgtga agtatgcatg cccaattcac gccctccgct 32581 gagttctggc caggaggctt ctcgccacat tcaaattgtt acaaagttca gctagagaat 32641 tccttctccc tgtggagttt caccccctgc tcctctggcc gatggatccc tgtggtgcca 32761 g~caggaatg ggctgcttgg gtcccagcaa gttcctgggt cctctacctc tgtatttcac ggctctct aacttgactc agctccaggt aaagctggaa acttcacctg caaacagacc 32821 ttcagcctct ccagtggggg tgtgtcttca ggagaggagg gtctaccttt cccacttccg 32881 cagttgggaa actcacagga attttttttt tttaatgtca acagataatt ctacatcttg 32991 gaaaactgcc cttcagaaat gagggacaaa ttaagacatt ccaagataaa taatagtcaa 33001 cattgcatgg gaatttttgg ccagaacaat taggcaagac agaaacaaaa ggcatccaaa 33061 ttggaaagga agaagtaata ttatctctgt ttgcagagga tatgatctta caggtagaac 33121 actgtaaata tttccccaaa atcactgtta gaactagtaa atgaattcag caaaaatgca 33181 gaatacaaaa tcaacacaca aaaatgagtt atgtatctat attggcatta aacaatctga 33291 agaggaaatt aagaaaacaa ttccatttac agtagcattg aaaataataa tattcttaga 33301 aataaactta accaaagagg tgaaagactt gtacacagaa aactacaaaa tgttgctgaa 33361 agaagctaaa gaagacacaa atagatggaa atacatccca tattaatgag ttggaagact 33921 taaaattgtt aagatgtcaa tactacccaa agtgatctac aaattcaatg caatccctat WO 00/09525 PC'fNS99/17712 EPI-109 9II _ 33481 tattaaataa aatcctaatt atgtttttgc agaaatagaa aaatcaaccc taaaattcat 33541 atggaaattc aaggaatcgc aaagaaccaa aacaatttcg aaaaaaaaaa atttttttta 33601 acttggtggt ctctcacttc ctgatttcaa aactacaagc tacagtaatc aaaaccatgt 33661 ggcataaaga cagacataca gactaatgga ataataaaga gcccagaaat aaacccttgc 33721 atatatggtc aaataattct caacaagggt gccaagacca tccaazgggg aaaagaaagt 33781 cttttcaaca aatggtgctg ggaaaactgt atgtccacat agaaaaaaat gaagttggac 33841 ccttaccttg caccatgcaa aaattaattc aaattcaaat tagattaaag acctaaatgt 33901 aagagctaaa actataaaac tcttagaaga aaacataggg ggaaattttc gtaacaagat 33961 ttagcaaaga tttcttgtat ctgataccaa aagtacaggc aacaatttaa aattatatga 39021 gttggactcc atcaaaatta aaaacttttg tatatcaaag gacactatca gcagagtgaa 39081 aaggcaaccc acagaatagg agaaaatatt tgcatatcat atatgtgata agggactaat 34191 atccagaata tataaagaac tcctatgact caacaacaaa aaaaacaaac aacctgattt 34201 aaaaatgggc aaagaacctg aacttcaaag aagttataca aatgaccagt aaacatatga 34261 aaagatgttc aacatcacta accactagag aaatacaaat caaaaccata atgaaatacc 34321 atttcacacc ccctaggatg gctattataa aaaacagaaa ataacaaatg ttggcaa a 34381 tatggagaaa ttggaactct tgtgcattgc tgtaggaatg taaaatggtg caaccactgt 39941 caaaaagagt atgacagttt ctcaacagat caaacataaa attaccatgt atattagtca 39501 aggttctcca cagagacaaa accaataggc tatatataga gagaaagata caagagggga 39561 tttattaggg gaattggctc atgtgattat ggaggctgat aagtcccaca acaggctttc 39621 tgcaaattgg agaccttaga atgccagtag catggcccca ttcaagtctg aaggcatgag 34681 aacccagggg gctgctagag tccaaaggat aaagagcctg gagtgctgat gtctaagggc 34791 aggagaagag tgtatcccac ctgcaagagc gagaaaaatc tctctgctat ttttgttcta 39801 tcctggctcc agctgattag atggtgcctg cccacattga gggcaaatct tccccactta 39861 gtccactcac actcacatgc caatatcctc tgtaaacaca ctcacagaaa caccaaaaaa 34921 taatgcttca cctgttctct agttattcct taatccagac aagttgacac ctaaaactaa 34981 tcatcacacc atgggaccta gcaattccac ttctgggcac aaaagaactg aaagccggga 35091 ctcaaagaga tacttgtata cccatgttca tagcagtatg attcacaatg gccaaaaggt 35101 gaaagcaacc caagtgtcca ttaacagatg aataaacaaa atgtgtattt atatataata 35161 tatatacaat aaaatattca gtcttaaaaa ctaaagaaat tctgacacat ggataacata 35221 gatgaacctt aaagacatta tgctaagtga aataagtcaa ccacagaggg acaaatattg 35281 tatgattcta cttacatgat gtacctagag tagtcaaatt catagagaca gaaagtagaa 35341 cagtggttgt taggggctac gaggagggga tgggcagtta gcatttaatg ggtatgaagt 35401 ttcattttgg gaaaataaaa aaattctgga gatgaatggt ggagactggc gcacaacaat 35961 atgaatgtac ttaatgaccc tgaactgtac acttaaaaat ggctaaaatg gtaaatttta 35521 agttatttat attttactac aaaaasaagg taacatacta aaatgatctc atgggttttg 35581 tgagaatcaa atgagatcca tgtagagaag ccttgtagtc tatatagccc ttcgcaaatg 35691 ttagctcttc ttagtcatta tcactccatt ttccccaatc tgataccatt atccacacac 35701 tttacccagc cacacttacc caacagcaca ctgtttgagt ttgagtgcta tctggtgaat 35761 actcatcttc attttgctaa accctggatg ccatgtgcta gccaacaata tcctattgtt 35821 ctggttctta aacaaaacaa aatctcaaag acttcttcct cttacctagt tttacccaat 35881 gattggcttt gaagcagtcc ttattcagta ataagaggtc accatgccat ggccaagaat 35941 agggcaaatc ttcctccaat tcagttgaac tccctggccg tctagcaaac aacatatctc 36001 ataacacatc ctttgagcag gtgaacaact ctgaaccttc tttgaaggaa caggattctg 36061 ggaaaggaat aaaagaaatg catgcagtgt gtattgagaa taaaatctat tagctaagaa 36121 ataaaaaatg aaaatgctac aacatgatca gttttgatgg actagacaac tctctgtaga 36181 gtagccacag ggctgaaccc tcaaatattc ccagaaagta tagacattgc tgtagaacca 36241 gcctgataat gcagcagtgc agaacttaag aatgatattt ctttctagaa agcagaccaa 36301 ttgatatctt catcctgtta ttgatcagaa tccacgtcag cattcaggtg ctctctggct 36361 acaagtttcc ttagctcttg caggcgctgc tcattgaaga tttctcttaa cacaggtaat 36421 gctaccagtc tcatctggca cctttttcat gcaatgacaa ctatccagga gttgctgcct 36981 ttccagatat cccctgcgag accaatgagg gattttattc catgactctt tgaagaggtt 36541 caaacatgga tcaaacatga agtagtatgt accccagcct tagaaattta atcttttatg 36601 actgggagaa agaacccaag tctctgtgcc ttcacagtct tgaatatctc tgcttgtttc 36661 acttacgttt acctcactca agattcttag tgtcatcgac atgactggtt aagaactcag 36721 gacttttcaa caaagttttc tgccagtgcc ccacaaatca tgactgtggt ctcccaaatt 36781 ctttgattct ccactaggtt ccctttctcc tccattcaaa gccccaaata acatttaccc 36891 tatatattta gtcccgtttt ttgtagaaat gcttctttgc ttgtgttccc cctacctttt 36901 catatcatac ctacatcgtt aactgaggct cagtcataac atcaacaaca gcatgaaaca 36961 tcccaccttc tgtcttcatt ttgctataaa ctggaggcaa aggaaatgct gtcactcagg 37021 gagtatatca atgaagggaa agactctcac aagacaggca ctgaggcagg agtcactagc 37081 acacagtgta taagtgaaat ctaaatataa aaaagcaagc acttgggata catcccttgc 37141 acacacctcc tcttttataa ccagtagagt gaagttggtt gctgaagtca cagaatcaat 37201 agtctatttc ccacagacgg ctgatgatag cagaacaagc cctggctaag tcccccaccc 37261 ttttcttgag tagctcattg ttatgagcca cggacccacc atcaccaggt cacatgttct 37321 gtactctttc ctaaaaacag tgacaaaata tgctgagcca tccatatttc ctcagttaca 37381 ttgagaggca ggagatataa caattaagca gtctctggag ccagagcaac ctgagctcaa 37491 accatgcctt agcttgcttg ttgtgggacc taggcaaagt tactgaaact tctttagaca 37501 tgtttatcaa taaaatgggt acagttgact ggctccaaga tttcttgacc tcttgatgta 37561 tttgccctgc ataattccta agactgtgat tataatggat tttactctta tgattaggtt 37621 ttcacatagc acagttgact ttaatacagg gagattatct gggtaggcct tgcctaaaca 37681 caagagccat ttaaaagcag agttctcccc agctggtcaa aagagagaat ctctggtcag 37741 agattcacag cataagaagg tttcaatgtg ccatcactgg ctctgagatg tagaaaccca 37801 catgtaagga ccaaaaagaa gcccttagga gctaagagct acagccctcc agccaatagc 37861 cagcaaagaa acaaggacct cggtcctaca accacagcca accaaattct gccaacaaga 37921 aaaatgagct tggaagctga ttcttctccc aaagattcca gataagagta caacaccttg EPI-109 9l2 _ 37981 atttcagcct tgtgagatcc taagcaaaga acccactcat gtccacccaa acttctgacc 38041 tacagaactg tgagctaaca aatgagtgtt gtaagccact aagtttgtgg aaatttgtta 38101 cacagcaata gaaaactaat acaatgagga cacagcaagt gcttaataaa tgttagcttt 38161 tattattact aactcattgg gatcagctac acagttgtaa gaaggctaaa gtaaaaatta 38281 tttatgcaag gctggcagtg caacatagca ttcagatcca gggtccattt ggtctaatat ggctgatatt aagtgtttct caaggggaga gacattattg gcattcagtg gggggagggg 38391 ttcatcctgt agaactgcct tggacatggc agtccattta tcatctctgg cttctcttcc 38401 cctagcagta gtcattgcaa caactgaaaa tgccactgta catttccaaa aatgctcctc 38461 cacaagggtt gagaactttg agaactactt taagggaaat ttcataagaa agcatgcgtg 38521 tcttaaatgc tgccataaag ctacctcaat aactacaatg ctactcaaat tacctgaccc 38581 taagaatcgc cagtggcact tgtttaaata taacgattcc caagttcttt ccctggagtc 38641 ccattccata gggctggggt ggagccccag gaatctatac tcttactcaa agaccccagg 38701 ttaatctttt gtttatgtaa gtttgccaaa cactgagtta gaaatatact cagccgtaca 38761 tgcatttagc aaaagttcac cacaacggaa caatgacaca ccaaaactct ttgaaactgt 38821 gccttctaca gagctgtaaa tctccttttg gaccattcca ttacacaagg tgtcctcttg 38881 gtcacacagt gattgcaaat gggactctag agtcatggaa atgggtatac tcttctcaaa 38991 ctttccatct ttaccagaat tacttcttaa agtgatatgc ttcatggtgt aaactagcac 39001 ttattaattt tttctaaata tttatcatat ttcatatact tttattttgg agatggagtt 39061 tcgctcttgt tgcccaggct ggagcgcaat ggcagatctc ggatcaccgc aacatccatc 39121 tcccgggttc aagcgattct ctggcctcag cctcctgagc agctgggatt acaggcatgc 39241 gccaccacgc ccggctaatt ttgtattttt agtagaaaag gggttctcca tgttggccag gctggtctcc aactcccgac ctcaggtgat gcgcccgcct cggcctccca aagtgttggc 39301 attacaggca tgagccaccg cgcccggccc atatactttt aatacatgtg gaattaataa 39361 aaacgtccat gcctccaatt ccgtggctat tttaccgtct tcctttttcg gacaagtccc 39421 tcaaaggtag cgctcttggc tccttccttt gcttatcccc taaccctgtc ctcctgaggt 39481 gccccctgga tttcctccaa ccccggcagg gtctgccttt ccgggatgat acaacgacct 39541 gccctgcatg ccatatccca ggcgcgtggg caccaaagtg tggaaaaacc gatgaatgac 39601 gttttctgtt tccgatactc tgcctgccag aatcccctgc cgcaccgccc caccacgaag 39661 cacatggaac ccacggacta cacgaggaca gaggtctgtt ctccctttac ctctcccatt 39721 tctttaacta tgcttctctc ggctggcatg ccctttcctc atctcactcc acacacgaac 39781 aggtttagca aataatatgc acgctgctgg gacgggccca agcatttccc tcccttgata 39841 gggcggaact aaaatgcaag ccccacagtt gtcagcaaag gacttccctg ttaccatggt 39901 aaagccgctg cgcctttatt gtggttgagg agtacttgca tcaacctaag agaaaattaa 39961 taagaaggaa gtctgcaggc tgaaaccctt caaattagcc tggactcgcc tgcatctggc 90081 tc~g8acaga gttaatctca ggagtgagaa tatagccctc cggtggacgc aactcgcgcc g ggctaac agaatgtctc caggggaggg gctctgcgtc cgttccgccc aggcccttcc 90141 ggctcacgcg ccgtacggaa gcgtgctcag cgctgggctt gtgctccgta cggaagtgtg 90201 ctttggcgca ccggaagccg actcaacaga gctatggcgg gtttgactgt gagagaccca 90261 gcggtggatc gttctctacg ttctgtgttc ggtgagagga attcgttgta gtcaagcttc 90321 ggggagggac tcccctctgc accttctatc tcatgaatcg ctaccggagc cgctgacggt 40381 tcggacgtgc agttctccct gcttatcctg tagggcgtcc aacctggtgg actcatgagc 40441 aaagagatat tcccattctg ccgaggtctc gtaggctttc cgcaatatca gtggggaagt 90501 tagactagcg ttcagcttct gtgcgtttct cctttcatga gcttcaatta ttctctagag 40561 gagaaggctc acggtaacag ctcctcactg tcccgtacta cttctcatcc tctgccccag 40621 aatacagact atatgctgag ggtatagatc ctagtgtcca cttactgtcc tctcctaagg 40681 actttcatcc tttgcttttt atctgtaaca ttttagtgca tcaatagtgg tagcggccac 40791 ctggtgtcct gagatggctt gtaagtgaat gaatgaatga actattaaga tctcctcaga 90801 ggaattttaa aaaggatcga aacgattctg aattatcttt ttggctgaaa taagttgttt 40861 ttaaaaatac gtgtgattat tttagagtac catttgaaag ggacatgaca aagtagttca 90921 gaatactttt taaacatctt tcactacatt catcgtcatt ctcccttaaa tgttgtatgt 90981 gtggaaatac ataggaacct gttttaaaaa ttatattaaa taacattgat attttttgta 41041 gtcactgatg agacttgcag atctttaggt aaataccagt gccaaagtat ttatttgcac 41101 caaagttaag gaaaatctaa cacgtgtcag atcagtctga gaactaacat ttgagagtac 91161 ctacacattt tgtatttagt ttcagtggta tatttccttt gttaagaggt ctgaagaaat 91221 acaatggaat tgggattgga gaacactatt ttgagtctta tatttgatga tataagttta 91281 ctttctcact aaagatctat gttataaact cagaatttta atgttaccta ttttcttcct 91391 tagtggggaa cattccttat gaagctactg aagagcagtt gaaggacatc ttttctgagg 91401 ttggacctgt tgttagtttc aggtgagatc cccttttcct tcatggtggg agcttcttaa 91461 aaatcaccac agatttggct cttagtaata atggcaggtt ttctttactg gtgacttttc 91521 acatacattt tgttcttgta acagctttat tgagatataa ttgatacact atacaattga 41581 catttattct tacctaaaat atgttttttt cgttaaaaat gttttttagg cagggcatag 91641 tgactcaagc ctgtaatccc agcactttgg gaggccgagg caggcggatc acctggggtc 91701 aggagttcga gaccagcctg accaatgtgg tgaaaccttg tctctactaa aaatacaaaa 41761 attagccgcc gtggtggccc atgcctgtag tcccagctac tcaggaggct gagacaggag 91821 aattgcttga acccgggagg cagagatagc agtgagccaa gatcatgcca ctgcactcca 41881 gcctgggcaa cagagcaaga ctccatctca ggaaaaaaaa aaaaaaagtt ttaaaaaata 41941 tttctgtgag gctgtcagag atataaggtt atttatgtta cagtgggccc aattaaagca 92001 tggcaatgtt agcaggaacc ctgtatgtgt gtaacatttg ttcctgacac ttggttctgc 92061 tctccagatt ggtatacgat agagagacag gaaagccaaa gggttatggc ttctgtgaat 42121 accaagacca agagacagca cttagtgcca tgcggaacct gaatgggcgc gaattcagtg 42181 ggagagcact tcgagtggac aatgctgcca gtgaaaagaa caaagaagag ctgaagagtg 42291 agtacaaatc caacttggat gcagtatgag ttagtaaaga tgtaacaatg aagattttcc 42301 atttctgata tgttttagaa tatgctgaaa tggttagcca cgcagcttgt ttattacttg 42361 actgacctga tgtgcctgag ttaggcaagt attatatata tctttttaaa aactttttat 42421 aaattttttt tcaagtaatt gtctgaaatt tctataccct tgctctggat ggagcagggc )=YI-109 913 _ 92981 aaggcctcaa accgtttcaa aactgttctg gcaagcactg tagggatgca tagggtcact 92591 gcagacctaa gcatgctgga ggcttgctag taagtgtata tctttaagaa acagataaag 42601 ttgacattag aaattcttca gttgctccag cctgggcgac agagtgagac tctgtctcaa 42661 aaaaaaaaaa aaaaaaaaga atttccattg ctaaggagtt atttccagtt aaagatgaat 42721 tcaaattcat caagccatta gtagtactaa ctgtggcatt agtcattcct gtcactcttt 42781 tcaggaattt ttgaagttag cgtatttttc tcttttaacc ttttgtttct gaaatgactt 92891 gttaaaagaa gtcaatgtgc ctagttctct aacttaggtt aacattgtcc ttccatgtga 92901 tcatgatccc cagctttcct ctgagaacag aaaatacact ctcactttcc tccacagaaa 42961 caagaggctt tcacatcatt tatttctcag ctctggagaa tctaaaatta tcagctggtt 93021 cttacagcag ccctgaaaag tagatatttg aaatgattta gctttttgtt ttgcctccct 93081 aactttcttg tactttcttc ttgattaggc cttggcactg gtgcccctgt cattgagtca 93141 ccttatggag agaccatcag tcctgaggat gcccctgagt ccattagcaa agcagttgcc 93201 agccttccac cagagcagat gtttgagctg atgaaacaaa tgaaggtggg aggaggcatt 93261 aggttatgaa taaagcaaat cacatcaggt tttcaaggag ttacttgaat tagttccctg 43321 agctcaaata gaaattgtct gtagaccacc atttcttgca ccttcaatat tctgtatgta 43381 cacagtatat tttacatttt gtacaaagag ctttctattt ttgtacacaa acacagctat 93941 ccaaacaatc cagctggagt tttgtggccc atagatgtca gatgtagata ttaaaatttg 43501 gcttttttcc taaatgataa tatcacagta tttgaaatgc ctctttcttc tcttgcctgc 43561 catgaccaag gtttttttgt gccatgcaaa aactaatgat aaagagcctc ttgaatatta 43621 catttctcag aggggaatgg ctctaaatca ctatcagttt ctaagtcata agtattaaac 93681 ctgaatctgc ttatcttctc agctctgtgt ccagaatagt ccccaggagg cacggaacat 93741 g~tggatccg aaccctcaac tggcttatgc tttgctgcaa gcacaggtag tgatgagaat 93801 t t g gaaattgccc tggtgagtgc ttctggttct tttatggaaa tggtcgggta 93861 aaccttgaat gggataggaa ctacctgatt gctttgttaa acagacagct cataggtttg 93921 tcttttcact ttttagaaaa ttctgcatcg ccagacaaat atcccaacgc tgattgcagg 43981 caaccctcag ccagtccatg gtgctgggcc tggctcagga tccaatgtgt caatgaacca 99091 gcagaatcct caggcccctc aggcccagtc tttggtaggg ctttatccct taacattttt 94101 ttgtatctgt cttagaatgt cattttcttt ttaggagaat atattgaaag aagaatggtc 94161 aggaaccaga gatgataatt tcaatttcca ggcataaaag caatttccag gttgcagagc 94221 acatgacatc tgaatgaata tagattcgat tccaagtttg taaaacaaag agatccttcc 99281 cgtatgccct tttcttataa gctaactttg tgtgtatgtg catgcctggc actgtggttg 99341 gcacttcgtt attccatatg cattatctca tttaatcctc aaagcaattg tatgaggttg 94401 gcactcttat tatctccatt cttactgatg aaaaaagtaa agcttgcttt caaagcatga 94461 cacaaaacct taaagccata aaaaattgat acatttgaaa actaaaaaat ttctatataa 49521 agaaaaaaat aagtatcaaa gacatgacaa attgagaaaa agtatttacc acacatgtga 99581 tggaaaacag actaataaag agcccatagt cattcacaag aatgtttatt gccttagagt 49641 gaaaaattgg aaatgtccta aatgtacgtc agtggaagaa tggagaaaat gtgtggtaca 99701 ttcatccagt gaaatactgt acaacagtta aataaactac acgtatcaac atgaatgact 99761 ttgaaaaaca taattccata cagcagttaa gatgaactag gatacataat atcaacacaa 94821 ctccaaaaca gtgacatacg gacatgaaac taagtgaata tggatgcatt cccgaaatgt 49881 aggatatatg tttctgcata aatccccaaa atatgtggaa tgagttgcaa aataatatat 49941 tgagtatgta atgattcata taaaattttg aaacattaag aagacgtctt agtggtcatc 45001 aaaggagaag agagcacagg atgcaattgg ggaagaccgt acaggccatt ggtttatttt 95061 atttacttat ttatttccta agctgggtgg ctattttatt ttctatatga tttgtatatc 95121 tgtaattttt cataataaat tttaaaaggc ctcctataaa ttagtaagaa aatttccaat 95181 aacccagtag aaaaatggga aatagacata aatatttcac aaaaggagaa atataaatat 45241 ataaaaattt attcaacttc aaaataagat aatgtaataa attatcattt atatatgtaa 95301 tgttataaga taatgtaaat agaaactaca ataagctacc atttttcatc tctcaggttg 95361 gcagaggtac agggcaggga ccagcaaaca tttttctgta aatgatcaga cagtaaatat 95421 ttttggcttt gcaagtcaca ggatctgcca cagctactct gccatggtag tatgaaatca 45481 gccataggca ataagtgaac aagtgtgtgt ggttgtgttc cgttaaaagt ttgtttataa 95591 aaccaggcag tgagcccgat ttggcccatg ggtcatagtt tgccaacccc tgctctaaat 95601 aaataaatac attttcagag atagaaaaaa aaagctaagg cccagagagg ttagctggtc 95661 caaaaattga cacaattata agtggcagat ctatttctga acctggtttt atctgacctc 95721 acagccagtt ttctcttaac tactttccta tacagctctt ccttttcttt tgtagagttt 45781 ~tgtgttcctt aaacgtatat gtgatttttt ttatataact tggcttttat tctttattta 95891 ttgagctgtt tctaattcaa gggactactc agttttttgg ggaatgcaca gatgaaaaga 45901 tgacattctc tttttctcaa cgagttttaa tgtagcattt aaaaaaatat atttcacatt 95961 cccccaaaac cagaattata tctaaggaca ggagtgagaa aagattggtt aaattaaaaa 96021 aaaaatttaa ttttaaaaat gtggactacc agcagttgtt ttttttaaaa gagtcccagt 96081 ctccttttat gtttcttggg tttagggctt tttttttttt ttttttttac tcttattggc 96191 agccccaatc atgaagttaa cagtaggtgt tatgtgctgc cttgccacac agataagact 46201 tgtcaatctc tacattgaga atatgttcca tcttaaccgt gttccatata accaggctca 46261 tgacgtatat tgcttctgtg gagtttaaag tgtgtgacaa atctaatgct gcataagaca 46321. tgccatacaa aaaggatgtt tagtagtgta tttggggctq ttcatttgaa gaggactttt 96381 aaggtcgtag acttagtata ttgagtatcc acagaggcat atacatactc tgtttttttt 46991 gcttggtcag ggtggaatgc atgtcaatgg cgcacctcct ctgatgcaag cttctatgca 46501 gggtggagtt ccagcaccag ggcaaatgcc agctgctgtc acaggacctg gccctggttc 46561 cttagctcct ggaggtaagt ttcatttagt cttcaccatt tcagtacttg ctaaagtttt 46621 gtcatagcca ctgttgcagt gcagccaaat atgataatgg gatccttagg taaaattaat 46681 acacagctag aaagtatata tcttaggtgg aggaaatagt agatttctta cgttaaatcc 46791 tgtatgtcta attataagaa cagggaaagg gacagtaaag tgaaagagca tagtaaaact 96801 tccaagttaa caagggggaa aatggaatga gtggaaacaa aatcaagcca gcaaaaatag 46861 agaagaggaa aaaagtaaga gacagtgtaa aataagtaat aataaatgta gagtaagatg 46921 gaaggaataa aaactaatgt agttgttact ctgctaaata tgaatgaact gtcagattag EPI-109 914 _ 46981 gttcaaaagc tcatgaagaa aacagacaaa aaaatacaag gtcacatttg ttatagcata 47041 ttaaactgac ataaaattgt attttaacaa acataatcag aacaaacaac aaaagggaaa 47101 aagagaaatt taaaagctat gtacatttat tgaaaatgta tagatcggca attaataaga.
47161 gtattgctca tatacttgta actgttcctt gttcaacaat tgtaactaag aagattgagt 47221 gaaataatga ttccccatat gaaacatctg tatgaacaca tgatgtatta ccaatattta 47281 aagttttttt atgtaacaaa cttggttttt gttaatttat ctaatctagg gtaggttgag 47391 tacaacacta ctcatggaga atgatttaat tctaaattgt tctgttctgt agagaatcca 47901 gtctgcagag ctaagttgat gaggaatgga agaagagatt ttttgaagaa atttctgcaa 47961 actcaggaat tttttgtatc tactttagga ttgttatgta tctactttat cctaatagag 47521 ttatacttgt atttaaatta tctttcatga caggaggtcc atgggtaagt gacattgttt 97581 tcctgtatta tagaagagct tcctgccaag agtttggtaa ccaatgaaat gaattattct 97691 tattgaactc actattctgt cactgaaaca taaagtacaa attgtaaata tactaacaaa 97701 ccccatcttc tctctcattg cattgttgaa tatcttcctt tgtaggtttc tgcttgtgga 97761 gcagaatgag gaaatttgta aactcagcca ctgttctaat ttttcttttc cgctgttcta 97821 attggtgttt tttcttgtct gccctttatc ttctaggagg aatgcaggct caggttggaa 47881 tgccaggaag tggaccagtg tccatggaac gggggcaagg taaataaata ttaatgtctg 97991 actaatgtta attggtcatg gaagtgttcc acatccacag tatctaatat ggcagccact 48001 aaccacccat ggctatttca atattaagtt aattaaaatt aagtaaaatt taaaactcag 48061 ttcctcagtc acaatagcca cattccaagt gctcagtggc cacaggtgac tagtggatac 98121 catacaggac attacagata tagaacattt ctatcatcgt aaaaagatct attggacagt 98181 gctggtctag actttccacc tggtgattca gagtccagct ctacaagaat tgataatgaa 48291 gcaagtggat cgtttgtttc ctgattccta gtctaataat tccactgaca tgttctctct 98301 ccctgtatgg atatctgttg actgagtaag gaattttaat aatgagcatg taaatatgtg 98361 gctgggtatg tagaagacta gatttaaacc ccagagaaaa ctgggaggga atcataggtc 48421 tgtaacgcct acttaatgaa catatgttgt accgtggctg tactgctata tacaacagta 48481 gctgctgctc caaaatctcc atgttgtttc ttcatgttac tggagtttga aggacaagaa 48541 agtgcagtgg ttcagttgga aacaatgtta ggaggagaga tcgtaagaaa agagaaggaa 48601 ctgagtgcat actatatgcc aggcacttta attttcataa ataatcttgt gagttaggtg 98661 gcagcacctc agttttacag gcaaagagtt ggaagctcag aataagttac tttctcaagg 48721 ggacaaggta agtaaatatt aatgtatgag taatgtggac tggatttggt gctcttattt 48781 tctcttccaa ctagtaagtg gcagagctaa gattcagaag tctttgactc cagaatctgt 98841 cctctttctg tcactccaca ctgcctctgt taacttccaa gcatattctt cagtgtcttc 98901 tactcttatt ccttgggaat aaaatgatgg gaaagactgc tttggacaag catagagaag 98961 cttaaggttt tttcttttgt agcatatggt ttataagtgg aacccattta aaaagcaaaa 99021 tattggccag gcgcagtggc tcatgcctgt aatcccagca ctttgggagg ctgaggtggg 99081 tggattgctt gagctcagag gtttgaaact agcctagaca acatggcaaa accccgtctc 49141 tataaaaaat acaaaaacta gttgggcaat ggtggtgtgc acttgtggtc ccagctactt 49201 gggaggccga agtggaagga tcacttgagc ccaacaggtt gagactgcag tgagccataa 49261 tcgggcacca ctgcactcca gcctgggcaa cagagcaaga ccctgtctca aagaatatat 49321 atatatacac acacacacac atatatatac acacatacat acataaacat taatatacaa 49381 gcctgtggtt tttacactgg ggttggttgc tgaagtgaca gaattaactt tttcttgtta 99441 gaagtctgac agcaggacaa actccctggc caaatatctc atattttctc taagcatcca 99501 atgcttttgt gctattgtac atccctctat ccccaccgca ccactgtcaa tagatcatat 99561 atgttcccca gagtatttct gcagtaatga gaaggtatta gggtttcagt catacttctg 49621 cctgtcatgg ggccagccct caatccatca ggttttagct gtttaacgca tacttgcaca 99681 agacatcttc ctattatagt tatcttcacc tttttgtcag aaattggcaa agggaagtga 99741 ctcatgtttt gagggtattt ccaggatgtc ttcatgcaga gactaagtga gatgagcttt 49801 cttttatagt ttccttcagt acccagcaga ggaagcaaga gtcttttcgt gtgtgcctag 49861 tttgtcttac ttttcctgaa atccatgctg cttttaatgc tgaaaggaga tggagatgtt 49921 tgagaagata cttcttgctt ccctgccatg tttgtttagt gtcggttccc atgtcatctc 99981 attagtcttt gtttgctgtt gtcatgatgt ttattatcaa agacttgctg tggcagagta 50091 tttcttgtgg agtgatattc tctttcatca tgtaaagttc attcactgca tttccccatc 50101 tgatacattt ttgacagcag aaatttttgt gctttaaaat gtgacaaaaa tagaattgcc 50161 gtacttcagt tatggccgtt tcagaatgaa tcttgccttc cagattcagt gcagtttctt 50221 ttatgttttg cttctgaaac tacatttatg ttctttgcat aactagaaga ttcaaaacta 50281 tcctttttat atattttttt cctaatgatt tcataaggag acctaacgga aaactagtag 50341 cagaggtgaa aatcgaaaat gtcaggttat tcccacctag atcaaaccag tgcccccatg 50401 ggattccctt tcaaaagcta tctggtcaaa atggaactat ttcagagacc caaaggagct 50961 agtgtagttt agggagattt tgtagcctgg agcaagccga tgaactcttg gctttttaac 50521 ttatatatgt aaatctcaat ctccatgtgt gtgtgtttct gcgtgtgtat gcaagctatt 50581 ttaagtgtct gctctttctc cttttgaact tactgcttac ctaggaaccc tacagcactc 50691 gcccgtggga cccgccgggc ctgcatcaat tgagcgagtt caaggtaccc attgtatctg 50701 tgggtttcct tttgcttgtg gtgttcaggg tgggacgttg agaggaaaag agctgcgtgg 50761 cagtcatcct cgcgttcaga acccaaaagg gtagtgtttt tgggtttttg tttttttaat 50821.tttttcctgt tgaggccaca agcctaagat tgacctcttc acacagggca gagaacatgg 50881 atgatatggg catctgtccg aggctgtact ccctccctac tggtgtcagg aggcttggat 50991 ggaatagcag tctgtaagga gacagcgggt tcttgcagag ccatggcagt gttcacatat 51001 gccaagactc tacctctgtt ttgtgactct ggtccttgaa ctaagattga ttagaaggaa 51061 aaccaggagc ataagtttct ccaggtcgca gtgctagtcc ttggcaggtt gctccccagt 51121 ttgctcttta tataattcca tccatacctc tgacatggca cagattctgc ctacaccctg 51181 cttctgttct tgagctgcaa gaggattctg ctgtggtgag gtttcaccca ctctaaggtg 51291 tctgaattat gttgtcagtg gtatatagag tcatttcttg tttgcttatg tgtctttcac 51301 agcagtaact ccccgtttgt ttccctgtca gtgccgatgc aagaccccag agcagctatg 51361 cagcggggat ccttgcctgc gaatgtccca acccctcgag gcttgttagg agatgctccg 51421 aatgatccac ggggaggcac tttactttct gtaactggag aggtagagcc taggtaagca EPI-109 915 _ 51981 ctaacataga aggaaacagt tgaagaaatc agaattgtcc cttcttccct gagaacaaaa 51591 tctttctgta ccagttgtac ctgtttgcct acttcaaaag gtagatcaat attcatggcc 51601 actgtccaag ggtaagcact tctcctaagg cagaactatg tacttgagta tgtcattttg 51661 agctattata tttttagaaa ttggaaattt tagtatacat acttgaacag ggaaatttat 51721 agtagtggaa atattaataa tagcaataat aggccgggtg cagtggctga cgcctataat 51781 cccagtactt tgggaggcca aggtgggtgg atcacttgag gtcaggagtt cgagacctgc 51891 ctggcctaca tggtgaaatc ccatctctac taaaaataga aaaattagcc gggcgtggtg 51901 gcgggcgcct ataattaca.g ctactgggga ggctgaggca ggagaatcgc ttgaacccag 51961 gaggtggagg ttgcagtgag ccgaggtcat gccactgcac tccagcctgg gcaacaagag 52021 tgaaactcca tttcaaaagt aaataaataa ataaaataat gatagtaata ataattgaca 52081 ttaatgggga tcatgcctct gactctgctc tgagtacttt acttagatca tcttattaaa 52141 tccacaagat cctgtgagat ggataccatt attagtccca ttttacacgt gaaactgatg 52201 tgtggaaaag ttaaataatg tgtccaatat cacacagcta ataagtgata gagcctagat 52261 ttgaacccat acagtctgaa tccagagctc atgttcttat gcattgttct gcaaactcat 52321 acatataatg aatattcgtt gattcctccc taattatgaa ccaaataacg aaattctaga 52381 atacatggat ttatatctct gtagcttttc ttccatctat ttggtgttat tttcttgtta 52441 gtattcatag actacatcag ctctttgttg gatgtttact tactgatctg gttggtactt 52501 tgttgttgtt ttgttctatt ttaaaataca acgtttttct ccatctccag aggttacttg 52561 ggaccacctc atcagggtcc acccatgcac catgtccctg gccatgagag ccgaggacca 52621 cccccacatg aactgagggg agggccatta cccgagccca gacctctaat ggcagaacca 52681 agaggaccca tgctagatca gaggggtcca cccttggatg gcagaggtaa ggggagatca 52741 cattgcaaat gccataatga actcaactgt cttaggctct aatctgggat aaagaatgct 52801 ggaacagtag gtttgcaagc atctttaagg tttatccaca aatctgagaa actggggagg 52861 agacaatagt ctcatatgtt aatagctgag gggacaaatg tgactagaag agatttctat 52921 ctttcttgga ttgttcatca ttcttgcagt acatgcaagt agctacataa tggttttgtt 52981 acatttttct ttataggtgg aagggatccc cgaggaatag atgcacgagg gatggaggcc 53091 cgagccatgg aggcaagagg gttagatgcc agaggattag aggcccgtgc aatggaggcc 53101 cgtgcgatgg aagctcgtgc aatggaggcc cgagcgatgg aggcccgtgc aatggaa tc g 53161 cgagggatgg aggccagagg catggatacc agaggcccag tgcctggccc cagaggacct 53221 atacctagtg gaatgcaggg tcccagtcca attaacatgg gggcggttgt cccccaggga 53281 tccagacagg tatgtgtaac actgacttct ggcatccaag tgaaatcttg atctattcag 53341 gaattgatta ttgagcctaa ttattactgc cttctgactt gggctgtttc ttagcttgtt 53401 agaaagggaa gacttggatc tccctgtagc ttctctgtcc cttagggtgg tgattttctg 53461 gctatcagga ttgtagttca aaaaaaaaca accttatccc acaataaata gctattcatt 53521 tggagcagag cccctgaaaa tttaggggtt agaaagtagt cttgattggg gtacaaacca 53581 acatcatgta cacggttttt tccaagatat acttgcccgg atctcatccg aggtataact 53691 cagaatctct tattagtagg atctgagcat ggatagtttg aaaaacttcc cccaaatgat 53701 tctaatgtga accctgactg ggaaccactg ggttagagta tatgaagagc tgttagtggc 53761 catttagata atcttaggtt tagagagacc tgtgttaatt tattgtcatc acatagccta 53821 agtgaacagt ggaatgtgaa aggcagttta ttaataatca ccttaaaagg tgtggaaccg 53881 aagtcttgtc tcctctcttt tatttggatc tctctgcctg tgtgtacatg ctccctcttc 53941 atctcgactt ggttgtggag aggtggtatg tgtgtttctt ccgtgagttt ttatatgctg 54001 gcaccttcat ttccctctaa ctgctccacc ttccttttcc ccccttcctc tgcgtacttc 54061 tctcttcttt ttttatgtgt cttcctcccc atgtctgtgt gtatgagaga gagaaagata 54121 atggcagagc tggaatggaa tacatcaatc atctaattcc ctcagtttat agatttggaa 54181 attaaggccc aagaattcag gtgacttgac caaattcaca tgactaaaaa gtggcagagc 54241 aaggaacaga agccactact ttttccactt tactactctg tcctgttatc tgcacatttg 59301 tgtgtgtgta tatgtgtgga tatgtgtcta ccccctcctc tgtaatatga aatacaaata 54361 gagggttttt ttgctatgtg tagaataaaa ctgttctcta ttgtgtttga agtgtttgtg 59421 ggccttgatt tttattgtac tctctatggt cagtagccta gtaacagaaa tggtttttat 59981 gcattcattc tgtcactcag caaatattta ttgagcacct actatgtacc aaacatagat 54541 ctaggtacgg gggatactgc agtgtgaaca gaacaaagcc ccttccccca tgggcttaca 59601 ttctagttgg gaagacagat aacaaacaaa taactacata atgcgcttac ataattttac 59661 tggtagttct atgatgcaag acattgcaag taagggttgg aagaacattt ctggataata 54721 ttttgctcct ttctctctgc tggtacttga acttattacc ctaatactag gtttatacca 54781 tttttattag tagattcgat aaagccaatt agatctgagg caagagaaaa tacaaatttt 54841 atcttcaaac ctttaaaaaa attttaaatt aatatattaa cttataaata tatatattcg 59901 ttcatctata aaagatatat gtattaagaa cttcaagcca ggcatggtga catgcacctg 54961 tagtgccagc actctggagg ctggggcagg aagaccattt aagtctagga acttgaggct 55021 gtggtgcatt ctgatcgcac ctgtgactag ccactgcact ccagcctggg cagcatatta 55081 gactcccatc tttaaaaaaa aaaaaaaagc cagggtagaa tcctgtagtc ccagctactc 55141 tggaggctaa ggcaggagga tcagtagagc ccaggagttg gaggcccgcc tacacaagat 55201 agtgagacca catcttaaac taaaaggaac cttgcttcct ctcctatgct tgtctcccct 55261 gtggccctct aggtcctgta gataatcact tttattagat ttttcatgtt actttctgga 55321 aaacatgaat atatattatt tttccccttt cactgttcta tacctttttt ttttttaact 55381 taacaacatg tccttaattc atacttttaa attagatttt aaaattaact ctagtccact 55441 tagttagaaa cttgtgggca aaaggcttat tattactagg gtgattatat aatttatcat 55501 ctaaaggaga acatgaaaga aagtgctgtt actttacttg gaggcaaaaa cataaactgg 55561 gactatctta gggaaaccaa gatgtatggt cacttttgct agtacttgtc tgcctagaac 55621 aagcacacct agaaacttaa aatggccgtt attgagtggt tagatcacaa ttacagtacc 55681 tcagattaaa gcttcaaaaa gattatactc aattccgaat tgtgctgcta taaactcatg 55791 tgaccaaaca ccacctgttc cccaataacc tatggaaata aaaaatttta aaaaaaaaga 55801 ttatactcat aggtgtttca gacccataat agctcgttaa tgttcagact ggtctctgga 55861 aacttgtctc tggtttcagt attgataatg aacagaacag tgataatatt ctagcagtct 55921 atacaaatct gtactaatgt ttcatctatc cattgtcttt gggaaatgag ttaatgcatg EPl-109 916 55981 taagtgaatg ttccagataa tagaactatt ctaccaagtt ttttaacttt tttaataaaa 56091 aattataaaa agtatttgat atttcctttc ttgaacagga tacaaaaaaa tagtttaatc 56101 agttttgact actcaaggtc atcattgaat agattcatta ttgtctatac cgtaatataa 56161 aacatagtta tctcctgttt ggtttctggt ctccttcact gtcaggccgt cacctggctc 56221 ttcatattac tgaagtggta tctgctccta acagttattt atccgtattt cttttatgtt 56281 ttgctgcttc taatctgctg ggtaagcagg taacaagttt gttaacaata tgtgtttatt 56341 aagagagtac ctaagctctg ggtgaatgcc tgagtgtgaa cataatgctt gtatagggac 56401 attctaacag ttagatttgg tactcaagag gtcttttcct tgggttctgg tagtcttgca 56461 aagggttgaa ctcattgaag atcttaagta ccagtaagta tgatatcact gtacttggtt 56521 ttttcactcc agtcagtcat attttttggt ctacatttag cagaaagcat ctgccatatg 56581 ttc (2) INFORMATION FOR SEQ ID N0:2693:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2693 1 ttcagttcta gcgtcaaccc ggtgctctac gtcttcaccg ctggagatct gctgccccgg 61 gcaggtcccc gtttcctcac gcggctcttc gaaggctctg gggaggcccg agggggcggc 121 cgctctaggg aagggaccat ggagctccga actacccctc agctgaaagt ggtggggcag 181 ggccgcggca atggagaccc ggggggtggg atggagaagg acggtccgga atgggacctt 241 tgacagcaga ccctacaacc tgctgccctt ccctgtccct ttccaccccc cacccaccct 301 ccagaggtcc tcccgacggc catgaacact acatcttctg cagcaccccc ctcactaggt 361 gtagagttca tctctctgct ggctatcatc ctgctgtcag tggcgctggc tgtggggctt 421 cccggcaaca gctttgtggt gtggagtatc ctgaaaagga tgcagaagcg ctctgtcact 981 gccctgatgg tgctgaacct ggccctggcc gacctggccg tattgctcac tgctcccttt 541 ttccttcact tcctggccca aggcacctgg agttttggac tggctggttg ccgcctgtgt 601 cactatgtct gcggagtcag catgtacgcc agcgtcctgc ttatcacggc catgagtcta 661 gaccgctcac tggcggtggc ccgccccttt gtgtcccaga agctacgcac caaggcgatg 721 gcccggcggg tgctggcagg catctgggtg ttgtcctttc tgctggccac acccgtcctc 781 gcgtaccgca cagtagtgcc ctggaaaacg aacatgagcc tgtgcttccc gcggtacccc 841 agcgaagggc accgggcctt ccatctaatc ttcgaggctg tcacgggctt cctgctgccc 901 ttcctggctg tggtggccag ctactcggac atagggcgtc ggctacaggc ccggcgcttc 961 cgccgcagcc gccgcaccgg ccgcctggtg gtgctcatca tcctgacctt cgccgccttc 1021 tggctgccct accacgtggt gaacctggct gaggcgggcc gcgcgctggc cggccaggcc 1081 gccgggttag ggctcgtggg gaagcggctg agcctggccc gcaacgtgct catcgcactc 1191 gccttcctga gcagcagcgt gaaccccgtg ctgtacgcgt gcgccggcgg cggcctgctg 1201 cgctcggcgg gcgtgggctt cgtcgccaag ctgctggagg gcacgggttc cgaggcgtcc 1261 agcacgcgcc gcgggggcag cctgggccag accgctagga gcggccccgc cgctctggag 1321 cccggccctt ccgagagcct cactgcctcc agccctctca agttaaacga actgaactag 1381 gcctggtgga aggaggcgca ctttcctcct ggcagaatgc tagctctgag ccagttcagt 1441 acctggagga ggagcagggg cgtggagggc gtggagggcg tgggagcgtg ggaggcggga 1501 gtggagtgga agaagaggga gagatggagc aaagtgaggg ccgagtgaga gcgtgctcca 1561 gcctggctcc cacaggcagc tttaaccatt aaaactgaag tctgaaattt ggtcaaaaaa 1621 aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1681 a (2) INFORMATION FOR SEQ ID N0:2694:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2694 1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaatt catggtggtg ttagaaatca gaagagaggc tacctttgtg 241 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301~gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 981 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 541 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag WO 00/09525 PCT/US99/177~2 EPI-109 917 _ 961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgacLgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa ' 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1741 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2401 aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2941 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3921 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3981 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3591 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3891 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 9021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 9081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 9261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 9321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 9381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4991 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 9501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 9621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 9681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 9741 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801.taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 9861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 9921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 9981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5341 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa EPI-109 gig 5961 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5941 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6291 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6421 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6481 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6541 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6891 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7141 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7441 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7741 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcaccttt cacatacatq tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8901 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag 8961 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8691 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301. acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9921 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9981 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcaa 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9891 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt 9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt .
10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10941 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11041 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11341 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11961 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11691 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11991 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12421 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12481 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12591 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12841 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13191 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13491 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14091 aagtccgtcc ccttcttaat caatgcagag gctacccact ccacattacc ttctcttcaa 14101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 19161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 19221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 14281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 14391 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 19901 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat 14961 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 14521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 19581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 19641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 19701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 19761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 19881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 19991 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15291 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15481 tcattccaga caccagccca acttgaactg tgccccaa.aa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16491 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct 16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16791 aatatcaccc cttaccacaa aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17091 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17641 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18291 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361.atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18981 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18541 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18891 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19441 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20041 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20391 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20901 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20961 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagc't ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20991 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag 21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22441 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22791 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23341 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23901 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23641 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23991 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 29181 cagaggtaag gctactcact gtttaaaccc ctttagtgat atcccaaaag acctcaagat 24291 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 29361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 29421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 24981 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 24591 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 24781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 24891 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 24901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25441 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa 25501 tctgccatct catcctacct gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26391 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26961 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27291 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27541 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29041 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29901 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29961 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29641 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29991 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30291 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30981 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30541 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaa't gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30891 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31141 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31941 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31741 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32391 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat WO 00/09525 ~ PCT/US99/17712 32961 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33291 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33921 actgacgcct ggatttgaat cctagccctg ccacttgata accatgtgcc tttaaacaag 33481 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33541 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 34141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 39201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 39321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 39441 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 34561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 34861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 39981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcaattcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35391 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35461 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35991 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36241 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacct caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36481 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36591 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36891 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt 36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37491 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37741 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38091 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38391 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38401 ttgtagggac tcagaaaata cctgttgtat gaaaagagca ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38991 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39291 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39421 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 90021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081.tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 90321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 90381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 90991 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 90501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 40621 tcctcctcct tcttttccac caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40791 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tggacgtcct tgttagtggc 90861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41041 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact WO 00/09525 PC'TNS99/17712 91961 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 41701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 91761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 91881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41991 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 92001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 92121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 92291 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 92301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 42421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 42481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 92541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 92601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 92661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 92721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 42781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 92841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 92901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 43021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 43081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 43141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 43201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 93381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43941 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa 43501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 93561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 93741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 93801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 93861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 93921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 93981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 49091 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 99101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 99161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 44221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 44341 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 49401 aatggggaaa aacgtggagc cagggagact tgtgaaagtg ccagtgctcc cactataccc 44961 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 44581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 44641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 99701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 49761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 99821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 44881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 94941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 95001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 95061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 95121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 95181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 95291 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 95301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 95361. attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 95421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 95481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 95541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 95721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 95781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 95891 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag WO 00/09525 PCTNS99/i7712 95961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 96021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 96201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 96381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 96501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 46561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 96621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46791 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 46921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 46981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 47091 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 97391 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 97401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 97961 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 47581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 47641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 97701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 97821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 97991 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 48241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 98361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 48421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48981 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48591 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 98601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 48661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 98721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 48781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 98961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 99021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 99081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 49191 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 49201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 99261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 99381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 99441 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 99501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 49561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 99681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 99741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 49801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 49861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 99921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 99981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggq gcagttgata 50391 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt 50961 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50941 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51291 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51591 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51891 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52191 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52441 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat 52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa 52791 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53391 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53401 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53461 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 59001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 59061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 59181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 54241 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 59301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 54361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga 59541 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 54661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 59721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 59781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 59841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga 59961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56041 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56341 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56401 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57241 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57921 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57481 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57591 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58141 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58791 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59091 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59391 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59901 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc 59961 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca caacaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59691 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt qttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60421 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61441 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62401 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62961 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361.gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63421 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63591 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63891 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga EPI-i 09 931 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 69021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081_attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 69141 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 69381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64941 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 69501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 64561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 64621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 69741 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 69801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 64861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 69981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65091 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65391 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66291 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66921 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66981 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66591 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66841 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67141 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 67441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67791 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68091 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68341 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt 68961 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68991 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69921 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69591 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70141 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag 70441 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga 70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70741 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71091 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71391 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71901 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71691 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga ?1821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72291 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72421 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72981 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72541 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73441 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 74281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74391 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74901 tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 79461 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 79521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 74581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 74641 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 74701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 74881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 74941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggaqagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75291 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75921 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76441 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctaga atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77391 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca WO 00/09525 PC'T/US99/17712 77961 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78981 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78591 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78841 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901 ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaaq 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79741 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80391 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80901 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80461 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80991 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81481 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact WO 00/09525 PC'T/US99/17712 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82941 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83091 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgtg aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83401 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa 83461 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83991 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc 84001 accatgccca gctaattttg tatttttagt agagacgagg tttctccacg ttggccaggc 84061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag 89181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa 84241 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 84361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 84421 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 84541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 84601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt 84721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg 89841 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 84901 tgattgcaga ctagacattt tgaattaaac attatagaga ttctggattc tcgagagagt 89961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85191 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtgccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85941 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgb ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85791 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt B5861.tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatqaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86391 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86901 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc 86961 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86941 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgcca'c tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87421 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87981 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87591 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87841 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901 gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88141 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88441 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89401 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89641 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90241 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361. gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90921 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90981 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90541 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90891 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91141 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91441 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92091 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92391 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401 caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92461 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92691 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92991 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93421 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93891 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 94081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 94201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 99321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 94381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94441 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 94501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 94621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 99681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 94741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 94801 cctttgacct agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 99861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 99921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 99981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95041 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95391 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95401 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca 95961 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95691 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95941 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc 96291 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96481 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96591 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97141 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac 97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg 97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct 97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca 97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag 97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc 97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat 97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa 97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt 97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag 98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta 98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat 98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc 98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat 98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat 98341 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga 98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac 98961 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca 98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat 98581 aggacacata aaatcctaga tctcacagaa ttgacattec agagagggaa aggtagacaa 98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa 98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca 98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc 98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa 98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag 98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca 99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta 99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat 99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct 99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg 99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta 99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg 99361~ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt 99921 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt 99981 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag 99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct 99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc 99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc 99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata 99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa 99891 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta 99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca 99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100141 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100491 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101091 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt 101341 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 101401 gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101961 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101691 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101941 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca 102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaagaa acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102291 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102921 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102481 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102541 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103191 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacatcaaa taaggaaata 103991 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861~taataaataa aaataaaat~a tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 104091 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 104161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 109281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 109391 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104401 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc WO 00/09525 PCT/US99/177.12 EPI-l09 940 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 109521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 104581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 104691 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 109701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 104821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104991 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105291 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105921 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105591 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105891 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aag,ggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106491 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106791 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107091 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107401 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107461 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107991 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108921 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108591 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108891 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta EPI-l09 941 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109441 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110041 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110391 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110991 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111241 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111921 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111481 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112191 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113091 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113401 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113691 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 119001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 119061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 119121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 119181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114241 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 114301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 114361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 119921 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 114481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 119541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 119601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa 119661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 119721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 119781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 114841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115141 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct ccctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115441 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa 115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggctt tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116391 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116901 aatggctctt gtgagcacca aatcattgtq agaaggaaaa cccatctctt acagccccct 116461 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116691 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116941 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt EP(-109 943 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118191 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118791 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119901 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119961 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119641 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaatt atttgattat aaattacttt cttcatatta gagttgtgaa 119941 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt 120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120421 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120981 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120591 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120891 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121191 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122391 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122901 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac WO 00/09525 PCT/US99/17~12 EPI-109 gq4 122461 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123921 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123981 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123541 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123891 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 129021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 129201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 129261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 124321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 129381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124941 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa 124501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 129621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 129791 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 124801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 129921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125041 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125391 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatctt aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125691 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125941 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126981 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126541 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct 126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127191 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127941 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127741 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128391 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401 ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128961 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128691 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129291 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttggcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 229421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129481 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129541 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130141 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130941 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130791 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc 130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131391 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt 131901 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131461 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131641 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131991 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132291 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132591 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132891 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133141 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct 133441 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactttct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 139101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 134281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 134341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134901 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 134461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 139581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 139701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 134881 attggacttc tttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135291 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacaqg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc 135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136141 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136441 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136791 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137091 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137341 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137901 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137461 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137641 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt 137941 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138241 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138421 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138541 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138891 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139141 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139491 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139741 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140041 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 140101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 190221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 190281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 140341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta 190401 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 190641 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 140761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 190821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 190881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 140991 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 191061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 191121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 141181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt 191241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 141421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aacagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 191591 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc (2) INFORMATION FOR SEQ ID N0:2695:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2695 1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 241 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 921 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag (2) INFORMATION FOR SEQ ID N0:2696:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2696 1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct 61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt 121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca 181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg 241 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag 301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat 361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct 421 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg 981 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa 541 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag 601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc 661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct 721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc 781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa 841 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact 901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg 961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt WO 00/09525 PCT/US99/177.12 1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa 1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac 1141 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca 1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa 1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca 1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct 1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc 1941 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg 1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat 1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa 1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat 1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca 1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc 1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata 1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga 1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt 1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg 2091 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta 2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt 2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag 2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa 2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct 2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag 2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat 2961 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga 2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc 2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa 2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat 2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg 2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca 2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg 2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta 2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta 3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt 3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga 3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac 3181 ttatc (2) INFORMATION FOR SEQ ID N0:2697:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2697 1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa 61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc 121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc 181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac 241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg 301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt 361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc 921 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat 981 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc 541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct 601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc 661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag 721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg 781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt 841 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta 901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc 961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat 1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa 1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat 1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat 1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt 1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt 1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc 1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga 1491 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgcg gcaggagaag 1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc 1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg 1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata 1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag 1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc 1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac 1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa 1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa 1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc 2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag 2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg 2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg 2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc 2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca 2341 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgtat ttctttgtaa 2901 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa 2961 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat 2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt 2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt 2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact 2?O1 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg 2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct 2821 ggg (2) INFORMATION FOR SEQ ID N0:2698:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2698 1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 281 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 241 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 921 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 981 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 541 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1141 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1682 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1741 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2091 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2221 tcttccaagc acagccactt ctgtqaacat ccctgacctg cttcctggcc gaaaatacat 2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2901 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2961 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2641 gccctctccc agggacctgc agtttgtgga agtgacaqac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2941 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3291 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3921 aaacaaagtg gtgacacca.t tgtctccacc aacaaacttg catctggagg caaaccctga 3981 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3541 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 9081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 9141 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 9381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4441 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 9921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 9981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5091 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5391 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5901 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5461 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5641 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761.ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac EPI-l09 952 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6421 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781 ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6841 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca (2) INFORMATION FOR SEQ ID N0:2699:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (8) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2699 1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 291 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 921 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag 1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct 61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt 121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca 181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg 291 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag 301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat 361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct 921 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg 481 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa 591 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag 601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc 661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct 721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc 781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa 891 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact 901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg 961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt 1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa 1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac 1191 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca 1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa 1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca 1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct 1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc 1441 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg 1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat 1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa 1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat 1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca 1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc 1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata 1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga 1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt 1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg 2041 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta 2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt 2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag 2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa 2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct 2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag 2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat 2961 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga 2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc 2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa 2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat 2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg 2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca 2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg 2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta 2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta 3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt 3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga 3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac 3181 ttatc 1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa 61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc 121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc 181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac 241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg 301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt 361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc 921 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat 481 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc 541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct 601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc 661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag 721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg 781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt 891 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta 901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc 961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat 1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa 1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat 1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat 1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt 1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt 1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc 1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga 1941 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgcg gcaggagaag 1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc 1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg 1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata 1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag 1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc 1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac 1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa 1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa 1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc 2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag 2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg 2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg 2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc 2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca 2391 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgcat ttctttgtaa 2901 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa 2961 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat 2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt 2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt 2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact 2701 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg 2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct 2821 ggg 1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 181 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 291 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 921 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 481 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 591 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1191 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1681 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1791 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2041 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2221 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat 2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2901 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2961 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2691 gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2991 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3241 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3421 aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3981 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3591 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4191 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 9201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 9261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 9381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 9941 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 9501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 9561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 9921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 9981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5041 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5341 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5401 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5961 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5691 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761 ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6921 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catqacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781.ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6891 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca (2) INFORMATION FOR SEQ ID N0:2700:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2700 1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg 61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg 121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc 181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg 241 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa 301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc 361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc 421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg 481 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg 591 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcqggcggg cggcgcgggt 601 ggcgccgagg ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt 661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc 721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata 781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc 841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg 901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct 1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact 1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg 1141 actcggacgt ctttgtgcc't tatggctacc tctaccccag aagccacccc ggcgacccgc 1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc 1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg 1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca 1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca 1991 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag 1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc 1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc 1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc 1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga 1791 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt 1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2041 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2341 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2401 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2461 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggaqttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa 2691 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga 2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc 2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a (2) INFORMATION FOR SEQ ID N0:2701:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2701 1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc 61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg 121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg 181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc 241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc 301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc 361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct 421 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg 981 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg 591 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc 601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc 661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga 721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct 781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc 891 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt 901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg 961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc 1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc 1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg 1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga 1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag (2) INFORMATION FOR SEQ ID N0:2702:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2702 1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt 121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg 181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata 241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac 301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac 361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc 421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc 481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc 541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca 601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat 661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag 721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc 781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc 841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc 901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac 961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg (2) INFORMATION FOR SEQ ID N0:2703:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2703 1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc 61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt 121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg 181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta 241 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc 301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg 361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga 421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct 981 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg 541 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact 601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact 661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg 721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg 781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga 841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg 901 ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag 961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg 1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca 1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt 1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga 1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc 1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt 1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga 1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa 1991 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg 1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc 1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac 1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg 1681 agcagtgaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID N0:2709:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2704 1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg 61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg 121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc 181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg 291 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa 301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc 361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc 421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg 981 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg 591 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt 601 ggcgccgagg ccgggggctq ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt 661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc 721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata 781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc 841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg 901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct 1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact 1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg 1141 actcggacgt ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc 1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc 1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg 1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca 1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca 1491 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag 1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc 1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc 1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc 1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga 1741 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt 1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2091 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2391 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2901 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2961 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggagttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa 2691 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga -2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc 2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a 1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc 61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg 121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg 181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc 241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc 301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc 361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct 921 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg 481 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg 541 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc 601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc 661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga 721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct 781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc 841 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt 901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg 961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc 1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc 1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg 1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga 1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag 1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt 121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg 181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata 241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac 301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac 361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc 421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc 481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc 541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca 601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat 661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag 721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc 781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc 841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc 901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac 961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg 1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc 61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt 121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg 181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta 291 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc 301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg 361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga 421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct 981 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg 591 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact 601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact 661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg 721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg 781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga 841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg 901.ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag 961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg 1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca 1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt 1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga 1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc 1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt 1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga 1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa WO 00/09525 PCT/US99/1??12 1941 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg 1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc 1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac 1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg 1681 agcagtgaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID N0:2705:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2705 1 cccccctcca agataatttt taaaaaacct tctcctttgc tcacctttgc ttcccagcct 61 tcccatcccc ccaccgaaag caaatcattc aacgaccccc gaccctccga cggcaggagc 121 cccccgacct cccaggcgga ccgccctccc tccccggggt tccgggcccg gcgagagggc 181 gcgagcacag ccgaggccat ggaggtgacg gcggaccagc cgcgctgggt gagccaccac 241 caccccgccg tgctcaacgg gcagcacccg gacacgcacc acccgggcct cagccactcc 301 tacatggacg cggcgcagta cccgctgccg gaggaggtgg atgtgctttt taacatcgac 36T ggtcaaggca accacgtccc gccctactac ggaaactcgg tcagggccac ggtgcagagg 921 taccctccga cccaccacgg gagccaggtg tgccgcccgc ctctgcttca tggatcccta 481 ccctggctgg acggcggcaa agccctgggc agccaccaca ccgcctcccc ctggaatctc 591 agccccttct ccaagacgtc catccaccac ggctccccgg ggcccctctc cgtctacccc 601 ccggcctcgt cctcctcctt gtcggggggc cacgccagcc cgcacctctt caccttcccg 661 cccaccccgc cgaaggacgt ctccccggac ccatcgctgt ccaccccagg ctcggccggc 721 tcggcccggc aggacgagaa agagtgcctc aagtaccagg tgcccctgcc cgacagcatg 781 aagctggagt cgtcccactc ccgtggcagc atgaccgccc tgggtggagc ctcctcgtcg 841 acccaccacc ccatcaccac ctacccgccc tacgtgcccg agtacagctc cggactcttc 901 ccccccagca gcctgctggg cggctccccc accggcttcg gatgcaagtc caggcccaag 961 gcccggtcca gcacagaagg cagggagtgt gtgaactgtg gggcaacctc gaccccactg 1021 tggcggcgag atggcacggg acactacctg tgcaacgcct gcgggctcta tcacaaaatg 1081 aacggacaga accggcccct cattaagccc aagcgaaggc tgtctgcagc caggagagca 1141 gggacgtcct gtgcgaactg tcagaccacc acaaccacac tctggaggag gaatgccaat 1201 ggggaccctg tctgcaatgc ctgtgggctc tactacaagc ttcacaatat taacagaccc 1261 ctgactatga agaaggaagg catccagacc agaaaccgaa aaatgtctag caaatccaaa 1321 aagtgcaaaa aagtgcatga ctcactggag gacttcccca agaacagctc gtttaacccg 1381 gccgccctct ccagacacat gtcctccctg agccacatct cgcccttcag ccactccagc 1941 cacatgctga ccacgcccac gccgatgcac ccgccatcca gcctgtcctt tggaccacac 1501 cacccctcca gcatggtcac cgccatgggt tagagccctg ctcgatgctc acagggcccc 1561 cagcgagagt ccctgcagtc cctttcgact tgcatttttg caggagcagt atcatgaagc 1621 ctaaacgcga tggatatatg tttttgaagg cagaaagcaa aattatgttt gccactttgc 1681 aaaggagctc actgtggtgt ctgtgttcca accactgaat ctggacccca tctgtgaata 1741 agccattctg actcatatcc cctatttaac agggtctcta gtgctgtgaa aaaaaaaatg 1801 ctgaacattg catataactt atattgtaag aaatactgta caatgacttt attgcatctg 1861 ggtagctgta aggcatgaag gatgccaaga agtttaagga atatgggaga aatggtgtgg 1921 aaattaagaa gaaactaggt ctgatattca aatggacaaa ctgccagttt tgtttccttt 1981 cactggccac agttgtttga tgcattaaaa gaaaataaaa aaaag (2) INFORMATION FOR SEQ ID N0:2706:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2706 1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg 61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct 121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg 181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga 241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc 301.tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg 361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact 421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg 481 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt 541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct 601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa 661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc 721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa (2) INFORMATION FOR SEQ ID N0:2707:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2707 1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct 121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac 181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc 291 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt 301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca 361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg 421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata 481 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc 591 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt 601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa 661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc 721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag 781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct 841 ggtqatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg 901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa 961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga 1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga 1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag 1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt 1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg 1261 gtggctcacg cctgtaatcc cag (2) INFORMATION FOR SEQ ID N0:2708 (i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2708 1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc 61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg 121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct 181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat 241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc 301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg 361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg 421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct 481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca 541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt 601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag 661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc 721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg 781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc 891 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt 901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag 961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc 1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg 1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga 1191 gctcctttat cagctgagcq gccatgggca gacctagcat tcaatggcca ggagtcacca 1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct 1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg 1321,gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc 1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct 1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag 1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca 1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac 1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa 1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca 1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg EPt-109 962 1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2901 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2691 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2991 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat (2) INFORMATION FOR SEQ ID N0:2709:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2709 1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg 61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct 121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg 181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga 241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc 301 tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg 361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact 421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg 981 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt 541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct 601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa 661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc 721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa 1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct 121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac 181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc 241 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt 301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca 361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg 421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata 981 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc 541 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt 601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa 661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc 721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag 781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct 841 ggtgatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg 901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa 961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga 1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga 1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag 1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt 1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg 1261 gtggctcacg cctgtaatcc cag 1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc 61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg 121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct 181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat 291 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc E?I-109 963 301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg 361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg 421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct 981 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca 541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt 601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag 661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc 721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg 781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc 841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt 901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag 961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc 1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg 1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga 1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca 1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct 1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg 1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc 1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct 1941 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag 1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca 1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac 1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa 1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca 1791 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg 1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2091 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2961 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2991 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat (2) INFORMATION FOR SEQ ID N0:2710:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2710 1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg 61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc 121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga 181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat 241 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact 301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct 361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg 421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct 981 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta 541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg 601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa 661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca 721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc 781 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc 841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag 901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa 961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc 1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta 1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga 1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat 1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc 1261 tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccctcaa gcagtcctcc 1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag 1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt 1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact 1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg 1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg 1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac 1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg 1741 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt 1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag 1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc 1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct 1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga 2091 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca 2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt 2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa 2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt 2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat 2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc 2401 agggagtgag ccataactgg cggctgctct tgcgccaatg (2) INFORMATION FOR SEQ ID N0:2711:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2711 1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag 61 accactatgg ccagccccca gctgatgccc ctggtqgtgg tcctgagcac tatctgcttg 121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac 181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc 291 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc 301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc 361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt 921 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt 981 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag 591 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc 601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa 661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctq 721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt 781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc 841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa 901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg 961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac 1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct 1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg 1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga 1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt 1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc 1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc 1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc 1491 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc 1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg 1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca 1621 ccatagaaga acagcagatg gcggtgatca gcag (2) INFORMATION FOR SEQ ID N0:2712:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2712 1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc 61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc 121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact 181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcg=ggg tgccgtcgtc 291 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc 301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc 361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc 421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt 981 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt 541 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac 601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac 661 tgccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg 721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg 781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc 891 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc 901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac 961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca 1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga 1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct 1191 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag 1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc 1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc 1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac 1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag 1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta 1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc 1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca 1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa 1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa 1791 as (2) INFORMATION FOR SEQ ID N0:2713:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2713 1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg 61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc 121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga 181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat 291 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact 301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct 361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg 421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct 981 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta 541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg 601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa 661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca 721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc 7B1 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc 841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag 901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa 961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc 1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta 1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga 1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat 1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc 126T tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccc~caa gcagtcctcc 1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag 1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt 1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact 1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg 1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg 1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac 1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg 1791 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt 1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag 1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc 1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct 1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga 2041 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca 2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt 2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa 2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt 2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat 2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc 2401 agggagtgag ccataactgg cggctgctct tgcgccaatg 1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag 61 accactatgg ccagccccca gctgatgccc ctggtggtgg tcctgagcac tatctgcttg 121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac 181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc 241 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc 301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc 361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt 421 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt 981 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag 541 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc 601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa 661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctg 721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt 781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc 841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa 901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg 961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac 1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct 1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg 1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga 1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt 1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc 1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc 1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc 1941 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc 1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg 1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca 1621 ccatagaaga acagcagatg gcggtgatca gcag 1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc 61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc 121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact 181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcgtggg tgccgtcgtc 241 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc 301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc 361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc 421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt 981 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt 591 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac 601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac 661 tqccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg 721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg 781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc 891 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc 901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac 961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca 1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga 1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct 1141 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag 1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc 1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc 1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac 1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag 1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta 1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc 1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca 1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa 1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa ~~~_ _~._._ ___._... ~",._,_.. .. .,~.._. __. .. . .. ~.~.""~.,~.~""~~ _ 1791 as (2) INFORMATION FOR SEQ ID N0:2719:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2714 1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg 61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc 121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg 181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag 291 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga 301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg 361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca 921 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag 981 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa 591 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg 601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg 661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga 721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta 781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt 841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag 901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag 961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga 1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac 1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata 1141 ctggttctca agaacttctt tcagagacaq gaatttctct ggatcctcgg aaaccagcct 1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata 1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt 1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg 1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa 1941 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt 1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc 1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa 1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat 1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct 1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata 1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa 1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga 1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc 1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag 2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat 2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag 2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa 2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg 2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca 2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt 2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact 2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca 2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta 2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat 2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg 2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa 2761 gtaaaagtct acctgtgttt ttttctaaaa aqgctgctca caagttctat ttcttgaaga 2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt 2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat 2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg 3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt 3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg 3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat 3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa 3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt 3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt 3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa 3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag 3981 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3591 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa (2) INFORMATION FOR SEQ iD N0:2715:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2715 1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg 61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc 121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg 181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc 241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc 301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg 361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc 421 tgctggccat ggagtactqc caaggaggag atctccggaa gtacctgaac cagtttgaga 481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc 591 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc 601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc 661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc 721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct 781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt 841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg 901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac 961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca 1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc 1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc 1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc 1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag 1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca 1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta 1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg 1941 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag 1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg 1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg 1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg 1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc 1741 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg 1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga 1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc 1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca 1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg 2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg 2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc 2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca 2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac 2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga 2391 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg 2401 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc 2961 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg 2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt 2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca 2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta 2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc 2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt 2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc 2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg 2941 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt 3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa (2) INFORMATION FOR SEQ ID N0:2716:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2716 1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc WO 00/09525 PC'T/US99/17712 121 gaggtcccat cagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg 181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc 241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct 301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat 361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga 921 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa 981 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg 541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg 601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga 661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct 721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc 781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca 841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg 901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga 961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca 1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga 1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga 1141 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc 1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc 1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga 1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca 1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga 1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga 1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc 1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat 1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc 1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct 1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg 1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc 1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta 1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa 1981 aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID N0:2717:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2717 1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg 61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc 121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg 181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag 241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga 301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg 361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca 421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag 481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa 541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg 601 ccaaagatgt tqatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg 661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga 721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta 781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt 841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag 901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag 961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga 1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac 1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata 1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct 1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata 1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt 1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg 1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa 1942 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt 1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc 1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa 1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat 1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct 1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata 1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa 1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga 1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc 1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag 2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat 2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag 2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa 2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg 2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca 2391 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt 2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact 2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca 2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta 2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat 2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg 2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa 2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga 2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt 2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat 2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg 3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt 3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg 3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat 3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa 3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt 3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt 3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa 3921 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag 3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa 1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg 61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc 121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg 181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc 241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc 301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg 361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc 421 tgctggccat ggagtactgc caaggaggag atctccggaa gtacctgaac cagtttgaga 481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc 541 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc 601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc 661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc 721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct 781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt 841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg 901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac 961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca 1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc 1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc 1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc 1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag 1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca 1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta 1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg 1941 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag 1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg 1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg 1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg 1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc 1791 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg 1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga 1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc 1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca 1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg 2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg 2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc 2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca 2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac 2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga 2391 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg 2901 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc 2461 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg 2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt 2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca 2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta 2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc 2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt 2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc 2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg 2991 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt 3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa 1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc 121 gaggtcccat cagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg 181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc 241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct 301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat 361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga 421 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa 981 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg 541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg 601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga 661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct 721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc 781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca 841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg 901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga 961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca 1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga 1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga 1191 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc 1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc 1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga 1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca 1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga 1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga 1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc 1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat 1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc 1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct 1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg 1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc 1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta 1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa 1981 aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID N0:2718:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear {xi)SEQUENCE DESCRIPTION: SEQ ID N0:2718 1 gaattcctct ggtcctcatc caggtgcgcg ggaagcaggt gcccaggaga gaggggataa 61 tgaagattcc atgctgatga tcccaaagat tgaacctgca gaccaagcgc aaagtagaaa 121 ctgaaagtac actgctggcg gatcctacgg aagttatgga aaaggcaaag cgcagagcca 181~cgccgtagtg tgtgccgccc cccttgggat ggatgaaact gcagtcgcgg cgtgggtaag 241 aggaaccagc tgcagagatc accctgccca acacagactc ggcaactccg cggaagacca 301 gggtcctggg agtgactatg ggcggtgaga gcttgctcct gctccagttg cggtcatcat 361 gactacgccc gcctcccgca gaccatgttc catgtttctt ttaggtatat ctttggactt 421 cctcccctga tccttgttct gttgccagta gcatcatctg attgtgatat tgaaggtaaa 481 gatggcaaac aatatgagag tgttctaatg gtcagcatcg atcaattatt ggacagcatg 591 aaagaaattg gtagcaattg cctgaataat gaatttaact tttttaaaag acatatctgt 601 gatgctaata aggaaggtat gtttttattc cgtgctgctc gcaagttgag gcaatttctt 661 aaaatgaata gcactggtga ttttgatctc cacttattaa aagtttcaga aggcacaaca EPI-109 g7z 721 atactgttga actgcactgg ccaggttaaa ggaagaaaac cagctgccct gggtgaagcc 781 caaccaacaa agagtttgga agaaaataaa tctttaaagg aacagaaaaa actgaatgac 841 ttgtgtttcc taaagagact attacaagag ataaaaactt gttggaataa aattttgatg 901 ggcactaaag aacactgaaa aatatggagt ggcaatatag aaacacgaac tttagctgca 961 tcctccaaga atctatctgc ttatgcagtt tttcagagtg gaatgcttcc tagaagttac 1021 tgaatgcacc atggtcaaaa cggattaggg catttgagaa atgcatattg tattactaga 1081 agatgaatac aaacaatgga aactgaatgc tccagtcaac aaactatttc ttatatatgt 1141 gaacatttat caatcagtat aattctgtac tgatttttgt aagacaatcc atgtaaggta 1201 tcagttgcaa taatacttct caaacctgtt taaatatttc aagacattaa atctatgaag 1261 tatataatgg tttcaaagat tcaaaattga cattgcttta ctgtcaaaat aattttatgg 1321 ctcactatga atctattata ctgtattaag agtgaaaatt gtcttcttct gtgctggaga 1381 tgttttagag ttaacaatga tatatggata atgccggtga gaataagaga gtcataaacc 1441 ttaagtaagc aacagcataa caaggtccaa gatacctaaa agagatttca agagatttaa 1501 ttaatcatga atgtgtaaca cagtgccttc aataaatggt atagcaaatg ttttgacatg 1561 aaaaaaggac aatttcaaaa aaataaaat (2) INFORMATION FOR SEQ ID N0:2719:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2719 1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaat't catggtggtg ttagaaatca gaagagaggc tacctttgtg 291 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301 gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 481 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 591 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag 961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgactgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1791 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2901.aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2991 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3421 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3981 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3541 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3841 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 9021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 4081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 9261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 4321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 4381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4441 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 4501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 9621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 9681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 4791 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801 taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 4861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 9921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 4981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5391 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa 5461 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5991 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6241 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6921 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6981 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6591 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6841 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7191 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7491 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7791 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcaccttt cacatacatg tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8401 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag 8961 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8691 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301 acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9421 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9481 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcas 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9841 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt 9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt 10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10991 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11091 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11391 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11461 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11691 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11941 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg EPt-109 975 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12921 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12981 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12591 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12891 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13141 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13441 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14041 aagtccgtcc ccttcttaat caatgcagag gctacccact ccacattacc ttctcttcaa 19101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 14161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 14221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 19281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 19341 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 14401 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat 19961 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 19521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 14581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 14641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 14701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 14761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 19881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 19941 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15291 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15981 tcattccaga caccagccca acttgaactg tgccccaaaa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16441 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct WO 00/09525 PCT/US99/i77~2 16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16791 aatatcaccc cttaccacad aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17091 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17691 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18241 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361 atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18481 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18591 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18841 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19941 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20091 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20341 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20401 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20961 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagct ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20991 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag WO 00/09525 PCT/US99l17712 21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22491 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22741 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23391 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23401 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23691 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23941 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 29181 cagaggtaag gctactcact gtttasaccc ctttagtgat atcccaaaag acctcaagat 29241 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 24361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 24421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 29481 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 29541 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 29781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 29841 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 29901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25491 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa 25501 tctgccatct catcctacct gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26341 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26461 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27241 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27591 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29091 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29901 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29461 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29691 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29941 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30241 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30481 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30591 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaat gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30841 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31191 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31991 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31791 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32341 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat 32961 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33291 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33421 actgacgcct ggatttgaa.t cctagccctg ccacttgata accatgtgcc tttaaacaag 33981 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33591 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 39141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 34201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 34321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 39491 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 39561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 39861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 34981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcasttcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35341 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35961 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35942 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36291 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacct caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36981 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36541 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36891 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt 36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37491 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37791 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38041 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38391 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38901 ttgtagggac tcagaaaata cctgttgtat gaaaagagca ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38941 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat EPI-109 98t 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39291 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39921 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 40021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081 tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 40321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 90381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 40491 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 90501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 90621 tcctcctcct tcttttccac caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40791 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tgqacgtcct tgttagtggc 90861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41091 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact 41461 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 91701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 91761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 41881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41941 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 92001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 42121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 42291 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 92301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 92421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 92481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 42541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 42601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 42661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 42721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 92781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 42841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 42901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 93021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 93081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 93141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 93201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 43381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43441 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa WO 00/09525 . PCT/US99/17712 93501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 43561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 43741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 43801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 93861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 93921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 43981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 44041 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 94101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 99161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 99221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 94391 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 94901 aatggggaaa aacgtggagc cagggaqact tgtgaaagtg ccagtgctcc cactataccc 49461 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 49581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 49641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 49701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 49761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 44821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 94881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 49941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 45001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 45061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 95121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 45181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 45291 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 45301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 45361 attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 45421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 45481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 45541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg.cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 95721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 45781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 45841 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag 45961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 96021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 46201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 96381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 46501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 96561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 46621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46741 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 96921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 96981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 97041 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 97391 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 47401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 97961 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 97581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 97641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 97701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 97821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 47941 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc WO 00/09525 PC'f/US99/17712 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 98241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 98361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 98421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48481 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48591 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 48601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 98661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 98721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 98781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 98961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 99021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 99081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 99141 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 99201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 49261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 49381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 49941 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 49501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 99561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 49681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 99741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 99801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 99861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 49921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 49981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggg gcagttgata 50341 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt 50461 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50991 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51241 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51591 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51841 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52191 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52991 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat 52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa 52741 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53341 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53901 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53961 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 54001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 54061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 59181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 59291 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 59301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 59361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga 54591 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 59661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 59721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 54781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 59841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga 54961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56091 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56391 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56901 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa EPl-109 985 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57291 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57421 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57981 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57591 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58191 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58741 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59092 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59391 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59901 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc 59461 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca cascaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59691 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt gttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60921 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61941 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt EPI-l09 9g6 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62901 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62961 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361 gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63921 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63541 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63841 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 64021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081 attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 69191 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 64381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64441 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 69501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 69561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 69621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 69791 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 64801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 69861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 64981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65041 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65391 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66241 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66421 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66981 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66591 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66891 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67191 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 6?441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67741 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68041 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68391 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt 68961 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68941 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69421 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69541 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70191 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag 70991 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga EPI-109 9gg 70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70791 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71041 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71341 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71901 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71641 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga 71821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72241 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72921 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72481 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72591 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73941 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 79281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74391 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74901'tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 74961 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 74521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 79581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 79691 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 79701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 79881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 79941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga EPl-109 9g9 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggagagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75241 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75421 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76941 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctag,~ atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77341 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca 77961 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78981 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78591 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78891 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901'ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaag 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79791 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80341 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80401 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80961 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80991 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81981 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82491 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83091 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgt.g aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83901 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa 83961 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83941 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc 84001 accatgccca gctaattt~g tatttttagt agagacgagg tttctccacg ttggccaggc 89061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag 84181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa 84291 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 89361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 89921 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 89541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 89601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt 89721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg 84891 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 89901 tgattgcaga ctagacatt.t tgaattaaac attatagaga ttctggattc tcgagagagt 89961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85141 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtqccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85491 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgc ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85741 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt 85861 tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatgaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86391 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86901 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc 86961 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86991 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgccac tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87921 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87481 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87591 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87891 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901'gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88191 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88941 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga bP1-109 992 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89901 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89691 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90291 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361 gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90421 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90981 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90591 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90841 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91191 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91941 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92091 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92391 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401'caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92961 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92691 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92991 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93921 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93841 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 99081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 99201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 94321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 99381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94491 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 99501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 99621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 94681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 99741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 99801 cctttgacct agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 94861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 94921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 94981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95091 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95341 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95901 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca 95461 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95641 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95991 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc 96291 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96981 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96591 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97191 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac EPI-109 ~4 97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg 97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct 97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca 97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag 97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc 97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat 97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa 97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt 97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag 98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta 98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat 98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc 98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat 98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat 98391 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga 98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac 98961 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca 98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat 98581 aggacacata aaatcctaga tctcacagaa ttgacattcc agagagggaa aggtagacaa 98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa 98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca 98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc 98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa 98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag 98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca 99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta 99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat 99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct 99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg 99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta 99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg 99361 ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt 99421 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt 99481 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag 99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct 99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc 99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc 99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata 99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa 99841 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta 99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca 99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100191 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100491 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101041 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt 101391 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 10140I gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101961 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101691 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101991 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca EPl-109 995 102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaagaa acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102241 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102421 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102981 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102591 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103141 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacat.caaa taaggaaata 103991 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861 taataaataa aaataaaata tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 109041 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 109161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 104281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 104341 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104901 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 109521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 109581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 109641 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 109701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 109821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104941 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105241 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105921 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105591 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105841 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aagggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106441 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106741 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107091 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107901 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107961 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107941 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108421 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108591 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108841 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109941 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110091 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110341 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110991 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111291 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111421 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111981 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112191 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113091 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113901 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113641 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 114001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 119061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 114121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 114181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114291 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 119301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 119361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 114421 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 119481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 119541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 119601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa 114661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 114721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 114781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 119841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115191 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct ccctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115491 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa 115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggc~t tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116341 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116401 aatggctctt gtgagcacca aatcattgtg agaaggaaaa cccatctctt acagccccct 116961 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116641 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116991 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118141 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118741 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119401 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119461 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119691 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaat.t atttgattat aaattacttt cttcatatta gagttgtgaa 119991 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt 120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120921 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120481 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120591 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120841 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121141 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122391 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122401 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac 122961 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123421 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123981 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123591 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123841 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 129021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 124201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 124261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 129321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 124381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124991 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa EPI-i 09 129501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 124621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 129741 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 129801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 124921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125091 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125391 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatett aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125641 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125991 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126481 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126591 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct 126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127191 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127491 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127791 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128391 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401' ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128961 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128641 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129241 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttgqcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 129421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129981 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129591 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130191 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130941 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130741 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc 130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131341 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt 131901 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131961 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131691 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131941 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132291 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132591 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132891 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133191 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct 133491 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactt:ct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 139101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 139281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 139341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134901 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 139461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 134581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 139701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 139881 attggacttc ttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135241 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacagg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc 135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136191 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136941 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136791 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137091 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137391 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137401 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137961 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137691 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt 137991 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138291 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138921 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138591 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138891 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139191 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139491 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt.tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139791 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140091 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 190101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 140221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 190281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 190341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta 140901 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 190691 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 190761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 140821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 140881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 190991 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 191061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 141121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 191181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt 141241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 191421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aacagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 141591 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc (2) INFORMATION FOR SEQ ID N0:2720:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2720 1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct 61 caagcaatcc tcctgccttg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 291 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 421 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg (2) INFORMATION FOR 5EQ ID N0:2721:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2721 1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg 61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg 121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag 181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct 291 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc 301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc 361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac 421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag 481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat 541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg 601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc 661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag 721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga 781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc 841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac 901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc 961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat 1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag 1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc 1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt 1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat 1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg 1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg 1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac 1941 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc 1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg 1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa 1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg 1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt 1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag 1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg 1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag 1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta 1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc 2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact 2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag 2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa 2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc 2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat 2391 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc 2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt 2961 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg 2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag 2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg 2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca 2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg 2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc 2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc 2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat 2991 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc 3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg 3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg 3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg 3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg 3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac 3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc 3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg 3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg 3981 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc 3591 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc 3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca 3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca 3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg 3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg 3891 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg 3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 9141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 9321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4991 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt 9501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt 9681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:2722:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2722 1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg 61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg 121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca 181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact 241 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca 301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct 361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga 421 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg 481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct 541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct 601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc 661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga 721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa 781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta 841 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat 901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc 961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt 1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag 1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca 1141 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg 1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt 1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt 1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca 1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag 1441 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac 1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt 1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc 1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct 1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag 1741 ggtaactttt gggtctgtca taaatagagg gccc (2) INFORMATION FOR SEQ ID N0:2723:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2723 1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct EPI-l09 1006 61 caagcaatcc tcctgcc~tg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 241 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 921 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg 1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg 61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg 121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag 181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct 241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc 301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc 361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac 421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag 481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat 591 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg 601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc 661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag 721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga 781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc 841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac 901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc 961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat 1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag 1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc 1191 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt 1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat 1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg 1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg 1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac 1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc 1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg 1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa 1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg 1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt 1791 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag 1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg 1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag 1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta 1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc 2091 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact 2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag 2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa 2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc 2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat 2391 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc 2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt 2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg 2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag 2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg 2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca 2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg 2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc 2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc 2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat 2991 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc 3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg 3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg 3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg 3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg 3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac 3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc 3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg 3921 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg 3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc 3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc WO 00/09525 PCTlUS99/17712 3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca 3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca 3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg 3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg 3891 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg 3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 9021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 9081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 9261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 9381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4491 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt 4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 9561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt 9681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg 61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg 121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca 181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact 291 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca 301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct 361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga 921 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg 481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct 541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct 601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc 661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga 721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa 781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta B41 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat 901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc 961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt 1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag 1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca 1191 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg 1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt 1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt 1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca 1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag 1991 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac 1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt 1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc 1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct 1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag 1791 ggtaactttt gggtctgtca taaatagagg gccc (2) INFORMATION FOR SEQ ID N0:2729:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2724 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa 61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag 121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct 181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta 241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg 301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa 361 gaaagtgcag gggacccgcc gtcggggtqg gggcggcgct gcccagcctc tgtcccactt 921 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg (2) INFORMATION FOR SEQ ID N0:2725:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2725 i atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc 61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc 121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg 181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc 241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc 301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc 361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg 421 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg 981 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 591 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 841 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac 1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg 1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca 1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag 1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg 1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc 1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa 1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg 1491 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc 1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga 1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat (2) INFORMATION FOR SEQ ID N0:2726:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2726 1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac 61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc 121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag 181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg 241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg 301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc (2) INFORMATION FOR SEQ ID N0:2727:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2727 1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181. ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc (2) INFORMATION FOR SEQ ID N0:2728:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/177i2 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2728 1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg (2) INFORMATION FOR SEQ ID N0:2729:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2729 1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121 cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 241 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 981 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctqaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat (2) INFORMATION FOR SEQ ID N0:2730:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2730 1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca 361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 921 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga 981 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 591 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc 1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc 1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt 1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac 1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc 1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact 1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc 1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc 1441 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc 1501. tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:2731:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2731 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa EPI-109 tOlO
61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag 121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct 181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta 241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg 301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa 361 gaaagtgcag gggacccgcc gtcggggtgg gggcggcgct gcccagcctc tgtcccactt 921 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg 1 atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc 61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc 121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg 181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc 241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc 301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc 361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg 921 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg 481 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 541 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 891 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac 1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg 1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca 1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag 1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg 1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc 1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa 1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg 1441 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc 1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga 1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat 1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac 61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc 121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag 181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg 241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg 301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc 1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181 ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc 1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg 1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121'cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 291 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 481 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctgaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat 1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca 361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 421 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga 981 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 591 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc 1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc 1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt 1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac 1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc 1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact 1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc 1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc 1491 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc 1501 tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:2732:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2732 1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagagqc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 921 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 981 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 891 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1191 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt (2) INFORMATION FOR 5EQ ID'N0:2733:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2733 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt 61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg 121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat 181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat 241 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca 301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg 361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc 421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca 981 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt 541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc 601 cacataaaag ttgacttgga aaaagacttc tgctgctaaa caaaagttga aactgccttg 661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga 721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat 781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac 841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa 901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc 961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc 1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag 1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga 1141 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag 1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc 1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta 1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta 1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa 1941 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct 1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt 1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc 1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg 1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact 1791 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta 1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt 1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc 1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca 1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc 2041 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca 2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt 2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat 2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt 2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc 2341 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct 2901 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag 2961 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc 2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag 2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag 2691 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg 2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga 2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa 2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg 2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata 2991 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat 3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta 3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc 3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc (2) INFORMATION FOR SEQ ID N0:2734:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D1 TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2739 1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg 61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat 121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag 181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga 241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg 301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa 361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt 921 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac 481 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt EPI-109 . 1013 541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 891 aagaaaaaaa aaaaa (2) INFORMATION FOR SEQ ID N0:2735:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (8) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2735 1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc 61 ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac 121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag 181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg 241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg 301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg 361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt 921 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta 981 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat 591 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca 601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa (2) INFORMATION FOR SEQ ID N0:2736:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2736 1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatgcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 241 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 421 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 591 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:2737:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2737 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt 61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg 121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat 181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat 291 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca 301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg 361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc 421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca 481 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt 541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc EPl-109 1014 601 cacataaaag ttgactt,:ga aaaagacttc tgctgctaaa caaaagttga aactgccttg 661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga 721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat 781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac 841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa 901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc 961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc 1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag 1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga 1191 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag 1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc 1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta 1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta 1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa 1441 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct 1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt 1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc 1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg 1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact 1741 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta 1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt 1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc 1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca 1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc 2091 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca 2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt 2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat 2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt 2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc 2391 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct 2401 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag 2961 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc 2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag 2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag 2641 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg 2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga 2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa 2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg 2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata 2941 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat 3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta 3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc 3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc 1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg 61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat 121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag 181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga 241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg 301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa 361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt 921 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac 981 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt 541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 841 aagaaaaaaa aaaaa 1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc 6l ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac 121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag 181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg 241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg 301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg 361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt 421 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta 981 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat 541 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca 601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa 1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatqcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 291 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 921 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 591 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:273B:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2738 1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca 61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg 121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc 181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa 291 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc 301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct 361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa 421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc 981 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt 541 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc 601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag 661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg 721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca 781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga 891 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga 901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga 961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt 1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc 1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca 1191 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc 1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc 1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc 1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa 1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt 1491 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca 1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac 1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga 1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc 1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc 1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca 1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac 1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc 1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt 1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa 2091 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat 2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa 2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc 2221 taactccatg ttcataagaa aaaaaaaa (2) INFORMATION FOR SEQ ID N0:2739:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2739 1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 181 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga 421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg 981 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga (2) INFORMATION FOR SEQ ID N0:2740:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2790 1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg 61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat 121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat 241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat 361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact 921 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 591 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg 1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca 1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga 1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca 1491 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac 1501 actactaaat gtttgtcttt aaaggcagct gg (2) INFORMATION FOR SEQ ID N0:2741:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2791 1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 181.ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 591 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat 601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt 781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 891 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1941 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg (2) INFORMATION FOR SEQ ID N0:2792:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2792 1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 241 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 981 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt 541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1441 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1741 ctt (2) INFORMATION FOR SEQ ID N0:2793:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2743 1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 241 attgaggtaa gagacagatt ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag 361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat 921 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat 481 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac 541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg 601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag 661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa 721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc 781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt 891 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat 901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat 961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac 1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg 1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact 1141 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg 1201 ggtgagaga (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2799 1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca 61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg 121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc 181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa 241 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc 301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct 361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa 421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc 481 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt 591 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc 601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag 661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg 721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca 781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga 891 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga 901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga 961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt 1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc 1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca 1141 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc 1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc 1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc 1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa 1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt 1941 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca 1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac 1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga 1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc 1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc 1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca 1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac 1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc 1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt 1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa 2091 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat 2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa 2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc 2221 taactccatg ttcataagaa aaaaaaaa 1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 1B1 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga 421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg EPI-109 Iplg 481 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga 1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg 61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat 121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat 241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat 361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact 421 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 591 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg 1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca 1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga 1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca 1441 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac 1501 actactaaat gtttgtcttt aaaggcagct gg 1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 181 ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 291 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 921 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 541 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat 601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt 781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 841 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1491 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg 1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 291 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 981 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt 541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1991 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1741 ctt 1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 291 attgaggtaa gagacagatt ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag 361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat 421 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat 981 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac 541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg 601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag 661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa 721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc 781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt 891 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat 901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat 961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac 1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg 1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact 1191 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg 1201 ggtgagaga (2) INFORMATION FOR SEQ ID N0:2745:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2795 1 aaggacacgg gcagcagaca gtggtcagtc ctttcttggc tctgctgaca ctcgagccca 61 cattccgtca cctgctcaga atcatgcagg tctccactgc tgcccttgct gtcctcctct 121 gcaccatggc tctctgcaac cagttctctg catcacttgc tgctgacacg ccgaccgcct 181 gctgcttcag ctacacctcc cggcagattc cacagaattt catagctgac tactttgaga 241 cgagcagcca gtgctccaag cccggtgtca tcttcctaac caagcgaagc cggcaggtct 301 gtgctgaccc cagtgaggag tgggtccaga aatatgtcag cgacctagag ctgagtgcct 361 gaggggtcca gaagcttcga ggcccagcga cctcggtggg ccagtgggga ggagcaggag 421 cctgagcctt gggaaacatg cgtgtgacct ccacagctac ctcttctatg gactggttgt 981 tgccaaacag ccacactgtg qgactcttct taacttaaat tttaatttat ttatactatt 591 tagtttttgt aatttatttt cgatttcaca gtgtgtttgt gattgtttgc tctgagagtt 601 cccctgtccc ctcccccttc cctcacaccg cgtctggtga caaccgagtg gctgtcatca 661 gcctgtgtag gcagtcatgg caccaaagcc accagactga caaatgtgta tcggatgctt 721 ttgttcaggg ctgtgatcgg cctggggaaa taataaagca cgctctttta aaaggt (2) INFORMATION FOR SEQ ID N0:2746:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single EPI-109 ~O~I
(D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2796 1 acagccttga ccttatgtca tgggttcaac ttggacactg aaaacgcaat gaccttccaa 61 gagaacgcaa ggggcttcgg gcagagcgtg gtccagcttc agggatccag ggtggtggtt . 121 ggagcccccc aggagatagt ggctgccaac caaaggggca gcctctacca gtgcgactac 181 agcacaggct catgcgagcc catccgcctg caggtccccg tggaggccgt gaacatgtcc 291 ctgggcctgt ccctggcagc caccaccagc ccccctcagc tgctggcctg tggtcccacc 301 gtgcaccaga cttgcagtga gaacacgtat gtgaaagggc tctgcttcct gtttggatcc 361 aacctacggc agcagcccca gaagttccca gaggccctcc gagggtgtcc tcaagaggat 921 agtgacattg ccttcttgat tgatggctct ggtagcatca tcccacatga ctttcggcgg 981 atgaaggagt ttgtctcaac tgtgatggag caattaaaaa agtccaaaac cttgttctct 541 ttgatgcagt actctgaaga attccggatt cactttacct tcaaagagtt ccagaacaac 601 cctaacccaa gatcactggt gaagccaata acgcagctgc ttgggcggac acacacggcc 661 acgggcatcc gcaaagtggt acgagagctg tttaacatca ccaacggagc ccgaaagaat 721 gcctttaaga tcctagttgt catcacggat ggagaaaagt ttggcgatcc cttgggatat 781 gaggatgtca tccctgaggc agacagagag ggagtcattc gctacgtcat tggggtggga 891 gatgccttcc gcagtgagaa atcccgccaa gagcttaata ccatcgcatc caagccgcct 901 cgtgatcacg tgttccaggt gaataacttt gaggctctga agaccattca gaaccagctt 961 cgggagaaga tctttgcgat cgagggtact cagacaggaa gtagcagctc ctttgagcat 1021 gagatgtctc aggaaggctt cagcgctgcc atcacctcta atggcccctt gctgagcact 1081 gtggggagct atgactgggc tggtggagtc tttctatata catcaaagga gaaaagcacc 1191 ttcatcaaca tgaccagagt ggattcagac atgaatgatg cttacttggg ttatgctgcc 1201 gccatcatct tacggaaccg ggtgcaaagc ctggttctgg gggcacctcg atatcagcac 1261 atcggcctgg tagcgatgtt caggcagaac actggcatgt gggagtccaa cgctaatgtc 1321 aagggcaccc agatcggcgc ctacttcggg gcctccctct gctccgtgga cgtggacagc 1381 aacggcagca ccgacctggt cctcatcggg gccccccatt actacgagca gacccgaggg 1991 ggccaggtgt ccgtgtgccc cttgcccagg gggcagaggg ctcggtggca gtgtgatqct 1501 gttctctacg gggagcaggg ccaaccctgg ggccgctttg gggcagccct aacagtgctg 1561 ggggacgtaa atggggacaa gctgacggac gtggccattg gggccccagg agaggaggac 1621 aaccggggtg ctgtttacct gtttcacgga acctcaggat ctggcatcag cccctcccat 1681 agccagcgga tagcaggctc caagctctct cccaggctcc agtattttgg tcagtcactg 1741 agtgggggcc aggacctcac aatggatgga ctggtagacc tgactgtagg agcccagggg 1801 cacgtgctgc tgctcaggtc ccagccagta ctgagagtca aggcaatcat ggagttcaat 1861 cccagggaag tggcaaggaa tgtatttgag tgtaatgatc aggtggtgaa aggcaaggaa 1921 gccggagagg tcagagtctg cctccatgtc cagaagagca cacgggatcg gctaagagaa 1981 ggacagatcc agagtgttgt gacttatgac ctggctctgg actccggccg cccacattcc 2041 cgcgccgtct tcaatgagac aaagaacagc acacgcagac agacacaggt cttggggctg 2101 acccagactt gtgagaccct gaaactacag ttgccgaatt gcatcgagga cccagtgagc 2161 cccattgtgc tgcgcctgaa cttctctctg gtgggaacgc cattgtctgc tttcgggaac 2221 ctccggccag tgctggcgga ggatgctcag agactcttca cagccttgtt tccctttgag 2281 aagaattgtg gcaatgacaa catctgccag gatgacctca gcatcacctt cagtttcatg 2341 agcctggact gcctcgtggt gggtgggccc cgggagttca acgtgacagt gactgtgaga 2401 aatgatggtg aggactccta caggacacag gtcaccttct tcttcccgct tgacctgtcc 2461 taccggaagg tgtccacgct ccagaaccag cgctcacagc gatcctggcg cctggcctgt 2521 gagtctgcct cctccaccga agtgtctggg gccttgaaga gcaccagctg cagcataaac 2581 caccccatct tcccggaaaa ctcagaggtc acctttaata tcacgtttga tgtagactct 2641 aaggcttccc ttggaaacaa actgctcctc aaggccaatg tgaccagtga gaacaacatg 2701 cccagaacca acaaaaccga attccaactg gagctgccgg tgaaatatgc tgtctacatg 2761 gtggtcacca gccatggggt ctccactaaa tatctcaact tcacggcctc agagaatacc 2821 agtcgggtca tgcagcatca atatcaggtc agcaacctgg ggcagaggag cctccccatc 2881 agcctggtgt tcttggtgcc cgtccggctg aaccagactg tcatatggga ccgcccccag 2941 gtcaccttct ccgagaacct ctcgagtacg tgccacacca aggagcgctt gccctctcac 3001 tccgactttc tggctgagct tcggaaggcc cccgtggtga actgctccat cgctgtctgc 3061 cagagaatcc agtgtgacat cccgttcttt ggcatccagg aagaattcaa tgctaccctc 3121 aaaggcaacc tctcgtttga ctggtacatc aagacctcgc ataaccacct cctgatcgtg 3181 agcacagctg agatcttgtt taacgattcc gtgttcaccc tgctgccggg acagggggcg 3241 tttgtgaggt cccagacgga gaccaaagtg gagccgttcg aggtccccaa ccccctgccg 3301 ctcatcgtgg gcagctctgt cgggggactg ctgctcctgg ccctcatcac cgccgcgctg 3361 tacaagctcg gcttcttcaa gcggcaatac aaggacatga tgagtgaagg gggtcccccg 3921 ggggccgaac cccagtagcg gctccttccc gacagagctg cctctcggtg gccagcagga 3481 ctctgcccag accacacgta gcccccaggc tgctggacac gtcggacagc gaagtatccc 3591 cgacaggacg ggcttgggct tccatttgtg tgtgtgcaag tgtgtatgtg cgtgtgtgcg 3601 agtgtgtgca agtgtctgtg tgcaagtgtg tgcacgtgtc ggtgtgcgtg catgtgcact 3661 cgcacgccca tgtgtgagtg tgtgcaagta tgtgagtgtg tccaagtgtg tgtgcgtgtg 3721 tccatgtgtg tgcaagtgtg tgcatgtgtg cgagtgtgtg catgtgtgtg ctcaggggcg 3781 tgtggctcac gtgtgtgact cagatgtctc tggcgtgtgg gtaggtgacg gccagcgtag 3841 cctctccggc agaagggaac tgcctgggct cccttgtgcg tgggtgaagc cgctgctggg 3901 ttttcctccg ggagagggga cggtcaatcc tgtgggtgaa gacagaggga aacacagcag 3961 cttctctcca ctgaaagaag tgggacttcc cgtcgcctgc agcctgcggc ctgctggagc 9021 ctgcgcagct tggatggaga ctccatgaga agccgtgggt ggaaccagga gcctcctcca 4081 caccagcgct gatgcccaat aaagatgccc actgaggaat gatg (2) INFORMATION FOR SEQ ID N0:2747:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2797 1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac 61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc 121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg 181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca 241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga 301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa 361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta 921 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg 981 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc 541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc 601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc 661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt 721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac 781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa 891 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc 901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc 961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc 1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga 1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct 1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc 1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc 1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc 1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag 1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc 1491 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga 1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg 1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat 1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac 1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa 1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga 1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg 1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat 1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag 1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc 2091 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac 2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa 2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg 2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga 2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta 2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc 2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc 2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca 2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca 2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc 2691 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga 2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc 2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca 2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt 2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga 2991 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa (2) INFORMATION FOR SEQ ID N0:2798:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2798 EPl-109 1023 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 591 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1941 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1791 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2091 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2391 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2961 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3291 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid WO 00/09525 PC'TNS99/17712 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2749 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 291 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 981 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 591 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 891 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2391 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2691 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt 3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag 3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga 3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt 3361. gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc 3921 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc 3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt 3591 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt 3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt 3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt 3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa (2) INFORMATION FOR SEQ ID N0:2750:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2750 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 891 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1941 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1791 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2091 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301~acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa aaattagcca 3921 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3591 cggcagagca agactccgtc tcgggaaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID N0:2751:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid -(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2751 1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc ' 61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc 121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca 181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg 291 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg 301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg 361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg 421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc 9B1 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc 541 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc 601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc 661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc 721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag 781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac B41 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac 901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc 961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga 1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc 1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc 1141 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg 1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg 1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt 1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg 1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag 1441 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct gctgcgcccg 1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag 1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga 1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa 1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc 1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc 1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc 1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt 1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg 1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata 2091 accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac 2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat 2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca 2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc 2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc 2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc 2901 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc 2961 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa 2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc 2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca (2) INFORMATION FOR SEQ ID N0:2752:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2752 1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac 61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc 121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg 181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca 291 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga 301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa 361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta 421 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg aP~-io9 ~oz~
981 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc 591 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc 601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc 661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt 721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac 781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa B41 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc 901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc 961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc 1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga 1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct 1191 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc 1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc 1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc 1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag 1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc 1941 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga 1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg 1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat 1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac 1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa 1791 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga 1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg 1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat 1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag 1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc 2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac 2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa 2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg 2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga 2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta 2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc 2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc 2961 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca 2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca 2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc 2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga 2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc 2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca 2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt 2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga 2941 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 591 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1791 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3241 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcasac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaadc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2091 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2961 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt 3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag 3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga 3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt 3361 gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc 3421 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc 3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt 3541 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt 3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt 3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt 3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 981 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 891 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1491 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2961 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2991 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301 acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa.aaattagcca 3421 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3591 cggcagagca agactccgt'c tcgggaaaaa aaaaaaaaaa aaa 1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc 61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc 121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca 181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg 241 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg 301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg 361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg 421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc 481 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc 591 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc 601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc 661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc 721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag 781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac 841 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac 901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc 961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga 1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc 1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc 1191 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg 1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg 1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt 1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg 1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag 1941 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct. gctgcgcccg 1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag 1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga 1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa 1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc 1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc 1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc 1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt 1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg 1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata 2091. accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac 2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat 2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca 2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc 2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc 2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc 2901 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc 2461 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa 2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc 2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca (2) INFORMATION FOR SEQ ID N0:2753:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2753 1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcq 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c (2) INFORMATION FOR SEQ ID N0:2754:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2754 1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc 61 cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac 121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc 181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg 241 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat 301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt 361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg 421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg 481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc 591 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc 601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct 661 cttctccgac gactacgggg gcaagaactg caagaagccg gccgagtacg gctacgtgag 721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca 781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc 891 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc 901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag 961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc 1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag 1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa 1191 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca 1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc 1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc 1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac 1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca 1491 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat 1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa 1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag 1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg 1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct 1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt 1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga 1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg (2) INFORMATION FOR SEQ ID N0:2755:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2755 1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcg 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c 1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc 6I cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac 121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc 181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg 291 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat 301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt 361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg 421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg 481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc 541 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc 601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct 661 cttctccgac gactacggg.g gcaagaactg caagaagccg gccgagtacg gctacgtgag 721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca 781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc 841 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc 901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag 961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc 1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag 1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa 1141 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca 1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc 1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc 1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac 1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca 1441 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat 1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa 1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag 1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg 1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct 1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt 1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga 1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg (2) INFORMATION FOR SEQ ID N0:2756:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2756 1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg 61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc 121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc 181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca 241 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg 301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg 361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag 421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa 981 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca 541 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg 601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa 661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg 721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct 781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc 841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc 901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg 961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca 1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg 1O81~tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc 1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca 1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt 1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca 1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt 1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc 1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa 1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag 1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc 1;P1-109 1033 1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca 1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttacagag 1741 aaaaagaggg caaaccctt~ tatcaaatga cctcaaatgc cacccaggca ttttggacca 1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca 1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat 1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttgatcattg 1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg gaaatgtcca 2091 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag 2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg 2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg 2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaag 2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt 2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg 2401 atccctgtat ttcaagacct ctgtcc (2) INFORMATION FOR SEQ ID N0:2757:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2757 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 291 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 981 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 891 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1191 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1791 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2758:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2758 1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca 121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg 181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat 291 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt 301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt 981 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg 541 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg 601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaaq tgctgggatt 661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt 721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc 781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc 841 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc 901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg 961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct 1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg 1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag 1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag 1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag 1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt 1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact 1441 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc 1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag (2) INFORMATION FOR SEQ ID N0:2759:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2759 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 921 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1191 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca EPI-l09 1035 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2091 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacaca.g caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2760:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2760 1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact 61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag 121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca 181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag 291 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg 301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg 361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa 921 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc 481 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac 541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg 601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag 661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg 721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc 781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc 891 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag 901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc 961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc 1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga 1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag 1141 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc 1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat 1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag 1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc 1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg (2) INFORMATION FOR SEQ ID N0:2761:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2761 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgetgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc (2) INFORMATION FOR SEQ ID N0:2762:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs IB) TYPE: nucleic acid fC) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2762 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttac~c ctaaatgata aaaatcacac actcgagctc (2) INFORMATION FOR SEQ T_~ N0:2763:
(i) SEQUENCE CHARACTERT_STICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic ac_d (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPT=ON: SEQ ID N0:2763 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt (2) INFORMATION FOR SEQ ID N0:2769:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2764 1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca eagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc (2) INFORMATION FOR SEQ ID N0:2765:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2765 1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca (2) INFORMATION FOR SEQ ID N0:2766:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION-: SEQ ID N0:2766 1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag (2) INFORMATION FOR SEQ ID N0:2767:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2767 1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 241 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 591 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg WO 00/09525 PCT/US99/1'7712 601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag 661 tctcactctg ttgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca 1191 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtgattgtg aacaacaaag agaaaaccac 1491 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1741 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagtc agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2391 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg 2401 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2461 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2691 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc 2991 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3241 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg 3921 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3981 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3541 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg 3891 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 9081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4191 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 9201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt (2) INFORMATION FOR SEQ ID N0:2768:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2768 1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 421 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 981 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 891 cccctgtgac aagcactatg ctagatc (2) INFORMATION FOR SEQ ID N0:2769:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2769 1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tqatggtagt ttgtatttgt gtgggatcgg 241 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 421 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 481 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 841 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc 901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca 961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct 1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca 1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1191 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac 1861 aggacacacc gt (2) INFORMATION FOR SEQ ID N0:2770:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2770 1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181.cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 241 cattttgttg gctacttgt~t gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 921 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 481 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg 541 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga 661 tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg EPi-109 1039 841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1191 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1991 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2091 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcctgt agccccagct actcaggtgg ctgaggtggt 2901 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2961 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2691 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3241 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3921 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 9081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4191 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 4201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 4261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 4321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 4441 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 4501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 4561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 9621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 4681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 4791 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 9801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 4861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 4921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5041 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct 5341 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5691 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg 5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg 5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc 5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga 5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag 5941 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg (2) INFORMATION FOR SEQ ID N0:2771:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2771 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 291 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 481 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 591 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt (2) INFORMATION FOR SEQ ID N0:2772:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2772 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 981 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt (2) INFORMATION FOR SEQ ID N0:2773:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2773 1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg 61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag 121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa 181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga 291 gaataccctt gaacctggga ggtggaggtt gcatgacctg a 1 tggacctcaa catgcacacc agtccgagca acaagagcg~ aactccatct caaaaaagaa 61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 921 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 981 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa (2) INFORMATION FOR SEQ ID N0:2774:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2779 1 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa 61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc 121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgctgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag 241 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt 301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg 361 aggccaaggc gggtggatca cctgagatca (2) INFORMATION FOR SEQ ID N0:2775:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear .
(xi)SEQUENCE DESCRIPTION: SEQ ID N0:2775 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata i81 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct (2) INFORMATION FOR SEQ ID N0:2776:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2776 1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag (2) INFORMATION FOR SEQ ID N0:2777:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2777 1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 291 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 921 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 981 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga 541 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc 721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg 781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc 841 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag 901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc 961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa 1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc 1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc 1141 ctagtca (2) INFORMATION FOR SEQ ID N0:2778:
(i) SEQUENCE CHARACTERISTICS:
!A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single !D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2778 1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc 61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag 121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct 181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc 241 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat 301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta 361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac 921 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc 981 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag 591 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccagacca atccaaccag 601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg 661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag 721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag 781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgq tggcagggga 841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt 901 gggcccctca ggtccagggq ttcctctggt gcatgtggcc ctgctccaca atggcctgct 961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt 1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc 1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct 2141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag 1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc 1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag 1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg 1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt 1941 ggactqacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta 1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga 1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag 1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc 1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt 1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc 1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct 1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg 1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac 1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg 2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag 2101 tttcgctctt gatgcccagg ctggggtgca atggag (2) INFORMATION FOR SEQ ID N0:2779:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2779 1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga 61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc 121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg 181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg 241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa 301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg 361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat 921 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat 481 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat 541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca 601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata 661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg 721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc 781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca fiPl-109 1043 841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg 901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta 961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct 1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt 1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga 1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt (2) INFORMATION FOR SEQ ID N0:2780:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2780 1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga (2) INFORMATION FOR SEQ ID N0:2781:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2781 1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat (2) INFORMATION FOR SEQ ID N0:27B2:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2782 1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 421 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt (2) INFORMATION FOR SEQ ID N0:2783:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2783 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga 61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 291 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 921 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 981 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg WO 00/09525 PC'T/US99/177~2 EPI-109 t044 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttcgt tgtcatagcg tggtgaacag agaagagaat gctactgcgt 781 ctcgtggaga gaggcca7gg gataccgcta aacatgcgac aatgcacagg acagtcccct 891 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag (2) INFORMATION FOR SEQ ID N0:2789:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2784 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag 61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg 121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag 181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga 291 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg 301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc 361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac 421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc 481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt 591 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc 601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata 661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg 721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct 781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc 841 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca 901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata 961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc 1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc 1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt 1191 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta 1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga 1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg 1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac 1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg 1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt 1501 gcccatgtca ggactcttgt aaaacagagc tc (2) INFORMATION FOR SEQ ID N0:2785:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xiySEQUENCE DESCRIPTION: SEQ ID N0:2785 1 gagctccagc tttccagctg tcttttggqt gagcctgtct tcctcaagct caagcttcct 61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 241 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 421 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481 ttgaatgagc ac (2) INFORMATION FOR SEQ ID N0:2786:
(i) SEQUENCE CHARACTERISTICS:
~(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2786 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga 61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat EPI-109 ~ p4g 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 981 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt 541 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc 601 ctacagagca ggcatggaga gaaggagaaa tacatacggg caggagccag gagagggagg 661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat 721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt 781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc 891 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg 901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct 961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga 1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa 1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca 1241 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac 1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc 1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag 1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag 1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca 1441 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg 1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca 1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg 1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt 1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca 1791 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg 1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca 1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa 1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta 1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca 2091 gcacttcagg aggctgaggt gggcggatc (2) INFORMATION FOR SEQ ID N0:2787:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2787 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt EPI-!09 1046 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2091 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2901 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2788:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2788 1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg 61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc 121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc 181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca 291 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg 301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg 361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag 421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa 981 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca 591 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg 601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa 661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg 721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct 781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc 841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc 901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg 961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca 1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg 1081 tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc 1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca 1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt 1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca 1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt 1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc 1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa 1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag 1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc 1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca 1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttacagag 1741 aaaaagaggg caaacccttc tatcaaatga cctcaaatgc cacccaggca ttttggacca 1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca 1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat 1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttgatcattg 1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg gaaatgtcca 2041 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag 2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg 2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg 2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaag 2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt 2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg 2401 atccctgtat ttcaagacct ctgtcc 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 6l~tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 981 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc B41 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1491 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2091 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2901 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg 1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca 121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg 181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat 241 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt 301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt 481 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg 591 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg 601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaag tgctgggatt 661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt 721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc 781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc 891 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc 901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg 961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct 1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg 1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag 1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag 1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag 1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt 1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact 1941 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc 1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag ~1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 291 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 921 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 981 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 9fi1 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1941 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttqggtag aaagagatac agagggg 1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact 61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag 121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca 181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag 241 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg 301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg 361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa 921 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc 981 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac 541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg 601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag 661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg 721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc 781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc 841 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag 901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc 961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc 1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga 1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag 1191 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc 1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat 1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag 1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc 1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt 1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca cagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc 1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca ' 1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag 1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 291 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 591 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg 601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag 661 tctcactctg ttgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca 1141 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtqattgtg aacaacaaag agaaaaccac 1941 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1791 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagtc agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2341 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg 2901 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2961 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2691 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc 2941 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3291 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg 3421 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3481 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3591 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg 3841 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 9081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4141 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 4201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt 1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 921 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 481 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 841 cccctgtgac aagcactatg ctagatc 1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tgatggtagt ttgtatttgt gtgggatcgg 291 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 921 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 981 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 891 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc 901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca 961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct 1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca 1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1141 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac 1861 aggacacacc gt 1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181 cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 291 cattttgttg gctacttgtt gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 421 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 981 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg 591 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga 661~tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg 841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1191 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1441 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2041 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcttgt agccccagct actcaggtgg ctgaggtggt 2901 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2461 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2691 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3291 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3921 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc~tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 4081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4141 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 9201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 9261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 9321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 9941 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 9501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 9561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 4621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 9681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 9741 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 9801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 9861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 9921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5091 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct 5391 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5641 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg 5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg 5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc 5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga 5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag 5991 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 241 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 981 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 541 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 981 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt 1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg 61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag 121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa 181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga 291 gaataccctt gaacctggga ggtggaggtt gcatgacctg a 1 tggacctcaa catgcacacc agtccgagca acaagagcga aactccatct caaaaaagaa 61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 421 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 981 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa 2 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa 61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc 121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgetgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag 291 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt 301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg 361 aggccaaggc gggtggatca cctgagatca 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata 181 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct 1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag 1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 291 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 921 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 481 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga 591 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc 721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg 781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc 891 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag 901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc 961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa 1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc 1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc 1191 ctagtca 1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc 61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag 121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct 181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc 291 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat 301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta 361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac 421 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc 981 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag 541 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccaqacca atccaaccag 601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg 661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag 721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag 781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgg tggcagggga 841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt 901 gggcccctca ggtccagggg ttcctctggt gcatgtggcc ctgctccaca atggcctgct 961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt 1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc 1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct 1141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag 1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc 1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag 1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg 1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt 1991 ggactgacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta 1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga 1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag 1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc 1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt 1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc 1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct 1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg 1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac 1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg 2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag 2101 tttcgctctt gatgcccagg ctggggtgca atggag 1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga 61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc 121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg 181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg 241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa 301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg 361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat 921 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat 981 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat 541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca 601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata 661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg 721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc 781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca 841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg 901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta 961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct 1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt 1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga 1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt 1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga 1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat 1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 921 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga 61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 241 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 921 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 481 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttggt tgtcatagcg tggtgaacag,agaagagaat gctactgcgt 781 ctcgtggaga gaggccaggg gataccgcta aacatgcgac aatgcacagg acagtcccct 841 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag 61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg 121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag 181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga 241 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg 301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc 361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac 421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc 481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt 541 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc 601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata 661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg 721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct 781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc 891 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca 901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata 961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc 1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc 1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt 1141 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta 1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga 1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg 1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac 1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg 1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt 1501 gcccatgtca ggactcttgt aaaacagagc tc 1 gagctccagc tttccagctg tcttttgggt gagcctgtct tcctcaagct caagcttcct 61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 291 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 921 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481' ttgaatgagc ac 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga 61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 981 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt WO 00/09525 PCT/US99/177~2 gp~_~Og 1055 591 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc 601 ctacagagca ggcatggaga gaaggagaaa tacatacqgg caggagccag gagagggagg 661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat 721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt 781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc 891 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg 901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct 961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga 1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa 1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca 1141 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac 1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc 1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag 1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag 1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca 1941 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg 1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca 1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg 1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt 1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca 1791 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg 1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca 1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa 1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta 1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca 2041 gcacttcagg aggctgaggt gggcggatc 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgq tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1191 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1941 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2901 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2789:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single iD) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2789 1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt 61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg 121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg 181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca 291 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga 301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag 361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt 421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag 481 ttgaatatca cctctcaaaa gcatcacctc tatctgcctc atctcacact gtactctcca 591 ataaagcacc ttgttgaaag as (2) INFORMATION FOR SEQ ID N0:2790:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2790 1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc 61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac 121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct 181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc 241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga 301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc 361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac 921 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac 481 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga 541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct 601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca 661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat 721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag 781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc 841 tggagttcag tggcatgatc atagctcacc acagcttcca actcgtgggc tcaagtgatc 901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa 961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct 1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct 1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc 1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc 1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa 1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag 1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc 1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg 1441 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt 1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc 1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc 1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta 1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca 1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt 1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt 1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat 1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc 1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat 2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac 2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg 2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg 2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg 2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga 2391 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca 2401 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc 2461 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata 2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac 2581 cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc 2691 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg 2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3291 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta (2) INFORMATION FOR SEQ ID N0:2791:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2791 1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct 61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg 121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa 181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta 291 ggagcccgta ggtcatcttg gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct 301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat 361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca 421 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt 981 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct 591 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt 601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca 661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa 721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc 781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg 891 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata 901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc 961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc 1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt 1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat 1191 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca 1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg 1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac 1321 tcaatgtgta cacctttgac tacagctgca gaagtgttcc tttagacaaa gttgtgaccc 1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct 1491 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc 1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc 1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt 1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa 1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat 1791 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga 1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag 1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc 1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat 1981 actactaata taactactgt ttccatgtcc catgatcccc tctcttcctc cccaccctga 2091 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg 2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg 2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg 2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc 2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat 2391 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt 2407. gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta 2961 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct 2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt 2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag 2691 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta 2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac 2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga 2821 gaaactgaaa tccc EPi-109 1058 (2) INFORMATION FOR SEQ ID N0:2792:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2792 1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt 61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg 121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg 181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca 241 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga 301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag 361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt 421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag 481 ttgaatatca cctctcaaaa qcatcacctc tatctgcctc atctcacact gtactctcca 541 ataaagcacc ttgttgaaag as 1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc 61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac 121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct 181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc 241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga 301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc 361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac 921 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac 981 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga 541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct 601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca 661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat 721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag 781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc 841 tggagttcag tggcatgat~c atagctcacc acagcttcca actcgtgggc tcaagtgatc 901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa 961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct 1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct 1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc 1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc 1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa 1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag 1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc 1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg 1991 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt 1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc 1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc 1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta 1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca 1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt 1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt 1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat 1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc 1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat 2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac 2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg 2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg 2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg 2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga 2341 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca 2901 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc 2961 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata 2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac 2581~cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc 2641 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg 2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3241 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta 1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct 61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg 121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa 181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta 241 ggagcccgta ggtcatcttg gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct 301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat 361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca 921 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt 481 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct 541 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt 601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca 661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa 721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc 781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg 841 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata 901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc 961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc 1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt 1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat 1141 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca 1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg 1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac 1321 tcaatgtgta cacctttgac tacagttgca gaagtgttcc tttagacaaa gttgtgaccc 1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct 1991 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc 1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc 1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt 1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa 1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat 1741 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga 1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag 1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc 1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat 1981 actactaata taactactg't ttccatgtcc catgatcccc tctcttcctc cccaccctga 2091 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg 2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg 2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg 2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc 2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat 2341 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt 2901 gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta 2961 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct 2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt 2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag 2641 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta 2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac 2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga 2821 gaaactgaaa tccc (2) INFORMATION FOR SEQ ID N0:2793:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2793 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 301 ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat 421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt 981 tcagtcaaag aacca (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2799 1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag 61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg 121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta 181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca 291 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg 301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc 361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg 921 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc 981 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct 541 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct 601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt 661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct 721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat 781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg 841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt 901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc 961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa 1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc 1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct 1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag 1201 tccccgggcc ccgagg (2) INFORMATION FOR SEQ ID N0:2795:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2795 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 291 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 921 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgctcga gagccgcgcg 981 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1991 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttc.t ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca (2) INFORMATION FOR SEQ ID N0:2796:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2796 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 591 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc taqtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg (2) INFORMATION FOR SEQ ID N0:2797:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2797 1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc 61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg 121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct 181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc 291 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc 301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg 361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc 421 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg 481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg 541 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg 601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg 661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc 721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc 781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg 841 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc 901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1941 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1791 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg (2) INFORMATION FOR SEQ ID N0:2798:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2798 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 291 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 981 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 891 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1491 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2799 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cqccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 291 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 921 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 981 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 891 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1191 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct 1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa (2) INFORMATION FOR SEQ ID N0:2800:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2800 1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg 61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg 121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa 181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg 241 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc 301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc 361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag 421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat 981 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt 541 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc 601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata 661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg 721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg 781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat 841 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca 901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga 961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt 1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa 1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct 1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa 1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc 1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt 1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt 1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag 1441 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt 1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg 1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct 1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg 1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag 1791 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat 1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag 1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac 1921 atttgacaaa taggactgcc tacatttatt attatgaagg tcgattgttg ttggaagtgt 1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt 2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg 2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac 2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg 2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg 2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc 2391 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac 2401 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa 2461 taatctctcc ccaaattttc caataataat tgag (2) INFORMATION FOR SEQ ID N0:2801:
(i) SEQUENCE CHARACTERISTICS:
EPI-) 09 1064 (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2801 1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg 61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc 121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc 181 gaccggcgcg cccctcqgcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc 291 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc 301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct 361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga 421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag 981 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc S41 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg 601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct 661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg 721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg 781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc 841 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg 901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc 961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac 1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa 1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc 1191 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg 1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga 1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca 1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg 1381 aagagagtga gggacagagg aaacgtttat cctggag (2) INFORMATION FOR SEQ ID N0:2802:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2B02 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 30i ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat 421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt 481 tcagtcaaag aacca 1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag 61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg 121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta 181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca 241 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg 301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc 361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg 421 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc 481 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct 591 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct 601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt 661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct 721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat 781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg 841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt 901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc 961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa 1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc 1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct 1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag 1201 tccccgggcc ccgagg 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg WO 00/09525 PCT/US99/177~2 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 921 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg 481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 591 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 891 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1941 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2091 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261~gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1491 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg 1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc 61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg 121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct 181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc 291 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc 301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg 361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc 921 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg 481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg 591 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg 601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg 661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc 721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc 781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg 891 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc 901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1941 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1741 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 291 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 921 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catqaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1191 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1941 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681. gg 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt EPI-l09 1067 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 591 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct 1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa 1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg 61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg 121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa 181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg 291 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc 301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc 361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag 421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat 481 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt 591 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc 601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata 661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg 721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg 781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat 891 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca 901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga 961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt 1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa 1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct 1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa 1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc 1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt 1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt 1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag 1991 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt 1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg 1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct 1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg 1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag 1741 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat 1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag 1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac 1921 atttgacaaa taggactgc~c tacatttatt attatgaagg tcgattgttg ttggaagtgt 1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt 2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg 2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac 2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg 2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg 2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc 2341 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac 2901 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa 2961 taatctctcc ccaaattttc caataataat tgag 1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg 61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc 121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc 181 gaccggcgcg cccctcggcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc 291 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc 301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct 361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga 421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag 981 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc 541 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg 601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct 661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg 721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg 781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc 891 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg 901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc 961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac 1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa 1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc 1141 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg 1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga 1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca 1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg 1381 aagagagtga gggacagagg aaacgtttat cctggag (2) INFORMATION FOR SEQ ID N0:2803:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2803 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 981 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 591 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat B41 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2091 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2901 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2961 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag (2) INFORMATION FOR SEQ ID N0:2809:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs EP!-l09 1069 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2804 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 291 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 981 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1491 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2091 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2391 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2901 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2961 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag (2) INFORMATION FOR SEQ ID N0:2805:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2805 1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct 61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga 121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt 181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac 241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc 301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag 361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag 921 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga 981 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag 541 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac 601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg 661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag 721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa 781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag 841 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct 901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg 961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact 1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca 1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt 1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg 1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc 1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct 1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc 1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact 1991 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg 1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc 1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac 1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag 1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc 1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag 1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac 1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag 1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga 1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc 2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc 2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc 2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc 2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc 2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg 2391 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg 2401 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg 2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg 2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt 2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag 2691 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc 2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag 2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg.tgccctccta 2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag 2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa 2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac 3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg (2) INFORMATION FOR SEQ ID N0:2806:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single 1D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2806 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 591 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781, gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1491 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2091 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2901 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2961 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 4B1 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 891 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag 1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct 61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga 121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt WO 00/09525 PCT/US99/177~2 EPI-i09 1072 181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac 241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc 301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag 361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag 921 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga 981 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag 591 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac 601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg 661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag 721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa 781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag 891 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct 901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg 961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact 1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca 1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt 1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg 1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc 1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct 1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc 1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact 1441 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg 1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc 1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac 1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag 1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc 1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag 1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac 1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag 1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga 1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc 2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc 2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc 2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc 2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc 2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg 2341 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg 2901 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg 2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg 2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt 2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag 2691 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc 2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag 2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg tgccctccta 2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag 2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa 2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac 3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg (2) INFORMATION FOR SEQ ID N0:2807:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: 5EQ ID N0:2807 1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc 61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag 121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca 181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt 291 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc 301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt 361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct 421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc 981 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga 541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt 601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt 661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg 721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa 7B1 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga 841 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg 901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact 961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat 1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg 1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca 1191 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg 1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt 1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc 1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa 1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg 1941 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata 1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt 1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc 1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag 1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa 1791 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg 1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt 1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg 1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct 1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca 2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac 2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa 2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg 2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat 2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc 2391 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct 2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg 2961 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct 2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct 2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta 2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc 2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg 2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag 2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga 2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata 2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc 3001 aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag 3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct 3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt 3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt 3291 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg 3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc 3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg 3921 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg 3481 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat 3541 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag 3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg 3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt 3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt 3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag 3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat 3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg 4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant 9081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat 9191 ggaaagtcag ggaaaggagg tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc 4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc 9261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag 4321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc 9381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg 9441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat 9501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat 4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg 4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt 9681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt 4741 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat 4801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc 9861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 9921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 9981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5041 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5961 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5991 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6921 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagg cgcatgggtg 7191 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7941 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7741 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg 7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8391 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8401' acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8461 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat 8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg 9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca 9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt 9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag 9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta 9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac 9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg 9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc 9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc 9981 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca 9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg 9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct 9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa 9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc 9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca 9891 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtgatggagg cagcctggag ggctggcact gaaaagagca agggatgggg agggagggcc 9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct 10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa 10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc 10191 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa 10201.agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc 10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac 10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct 10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa 10441 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc 10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc 10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga 10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc 10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag 10791 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac 10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag 10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc 10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc 10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata 11091 acatgg (2) INFORMATION FOR SEQ ID N0:2808:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2808 1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121 atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 291 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 921 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 981 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc 661 tggtcgcagt tcaacaaggt tcagttctcc (2) INFORMATION FOR SEQ ID N0:2809:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2809 1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact 61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt WO 00/09525 PCT/US99/177~2 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 921 gcactttggg aggctgaggc gggcggatca caaggtcaag aaatcgagac catcctgacc 981 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctggqcat ggtggcgcat 591 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc (2) INFORMATION FOR SEQ ID N0:2810:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2810 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat 61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 421 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 481 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 591 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 891 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac 1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1741 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggagat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2901 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2961 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641,ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2991 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac cP~-io9 ~ o~~
3291 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg 3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3421 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3481 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca 3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3841 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg 3961 gtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 9021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 4191 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 4321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc 9441 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 9501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga 4621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 9681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 9741 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 9801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 9861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 9921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 4981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5341 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5901 ccaattctgg gggcaaatgt gcca (2) INFORMATION FOR SEQ ID N0:2811:
(i) SEQUENCE CHARACTERISTICS:
fA) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2811 1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt 61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg 121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag 181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga 241 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc 301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat 361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt 421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt 481 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga 541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta 601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac 661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta 721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct 781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg 891 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt 901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa 961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg 1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg 1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga 1191 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca 1201 ccaactgggg ttggccctta ggtccatgtg ggacattgag atcccagatt gcccatagtg 1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc 1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc 1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga WO 00/09525 PCT/US99/177~2 EPI-l09 1078 1441 tgccacccag cctccactcc caagctgcca ctcac (2) INFORMATION FOR SEQ ID N0:2812:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2812 1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc 61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag 121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca 181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt 241 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc 301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt 361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct 421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc 981 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga 541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt 601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt 661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg 721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa 781 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga 891 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg 901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact 961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat 1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg 1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca 1191 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg 1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt 1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc 1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa 1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg 1441 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata 1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt 1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc 1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag 1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa 1741 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg 1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt 1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg 1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct 1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca 2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac 2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa 2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg 2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat 2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc 2341 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct 2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg 2461 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct 2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct 2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta 2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc 2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg 2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag 2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga 2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata 2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc 3001,aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag 3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct 3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt 3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt 3291 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg 3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc 3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg 3921 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg 3981 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat 3591 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag 3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg 3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt 3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt 3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag 3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat 3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg 4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant 4081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat 9141 ggaaagtcag ggaaaggagg tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc 4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc 9261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag 9321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc 4381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg 9441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat 9501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat 4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg 4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt 4681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt 4791 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat 9801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc 4861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 4921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 4981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5091 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5961 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5941 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6921 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagq cgcatgggtg 7141 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7941 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7791 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg 7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8341 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8901 acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8961 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat 8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg 9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca 9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt 9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag 9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta 9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac 9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg 9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc 9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc 9481 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca 9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg 9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct 9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa 9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc 9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca 9841 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtgatggagg cagcctggag ggctggcact gaaaagagca agggatgggg agggagggcc 9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct 10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa 10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc 10141 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa 10201 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc 10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac 10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct 10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa 10941 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc 10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc 10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga 10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc 10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag 10741 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac 10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag 10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc 10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc 10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata 11091 acatgg 1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121~atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 291 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 921 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 981 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc EPI-109 ' 1081 661 tggtcgcagt tcaacaaggt tcagttctcc -1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact 61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 421 gcactttggg aggctgaqgc gggcggatca caaggtcaag aaatcgagac catcctgacc 481 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcat ggtggcgcat 541 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat 61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 921 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 981 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 541 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 841 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac 1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1791 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggaqat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2401 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2961 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641 ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2941 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac 3241 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg 3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3921 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3981 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc ' 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca 3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3891 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg 3961 qtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 9021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 9191 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 9321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc 4941 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 4501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga 9621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 4681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 4791 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 9801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 4861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 4921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 9981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5391 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5401 ccaattctgg gggcaaatgt gcca 1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt 61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg 121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag 181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga 291 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc 301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat 361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt 421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt 981 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga 541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta 601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac 661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta 721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct 781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg 841 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt 901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa 961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg 1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg 1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga 1141 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca 1201 ccaactgggg ttggccctta ggtccatgtg ggacattgag atcccagatt gcccatagtg 1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc 1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc 1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga 1941 tgccacccag cctccactcc caagctgcca ctcac (2) INFORMATION FOR SEQ ID N0:2B13:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2813 fiP1-t 09 1083 1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga 61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc 121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg 181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag 291 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc 301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg 361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca 421 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg 481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca 591 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc 601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg 661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg 721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt 781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa 841 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa 901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta 961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat 1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat 1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt 1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg 1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga 1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga 1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag 1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa 1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc 1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca 1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag 1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa 1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa 1741 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg 1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt 1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc 1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata 1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta 2091 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta 2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg 2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac 2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact 2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg 2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga 2901 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca 2961 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact 2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg 2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag 2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca 2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg 2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg 2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta 2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata 2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc 3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc 3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt 3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc 3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa 3291 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga 3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca 3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg 3421 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca 3481 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa 3591.attgagagaa tggaaaacag cccgccc (2) INFORMATION FOR SEQ ID N0:2819:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2814 1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga WO 00/09525 PCT/US99/177~2 61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg 121 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc 181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg 241 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg 301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg 361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 421 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 541 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 841 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1491 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2391 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2401 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2991 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3181 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3921 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3981 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3591 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 cttagtgaaa tgacttccgg aatct (2) INFORMATION FOR SEQ ID N0:2815:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2815 1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga 61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc 121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg 181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag 291 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc 301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg 361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca 921 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg 481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca 541 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc 601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg 661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg 721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt 781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa 891 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa 901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta 961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat 1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat 1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt 1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg 1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga 1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga 1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag 1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa 1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc 1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca 1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag 1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa 1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa 1791 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg 1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt 1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc 1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata 1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta 2091 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta 2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg 2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac 2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact 2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg 2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga 2401 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca 2961 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact 2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg 2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag 2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca 2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg 2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg 2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta 2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata 2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc 3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc 3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt 3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc 3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa 3291 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga 3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca 3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg 3921 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca 3981 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa 3541 attgagagaa tggaaaacag cccgccc 1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga 61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg 122 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc 181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg 291 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg 301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg WO 00/09525 PC'T/US99/17712 361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 921 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 591 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 891 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1941 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2341 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2901 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2991 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3161 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3421 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3481 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3591 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 cttagtgaaa tgacttccgg aatct (2) INFORMATION FOR SEQ ID N0:2816:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acizi (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2B16 (2) INFORMATION FOR SEQ ID N0:2817:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2817 (2) INFORMATION FOR SEQ ID N0:2818:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2818 (2) INFORMATION FOR SEQ ID N0:2819:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2819 (2) INFORMATION FOR SEQ ID N0:1:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1108 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:1:
1 cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 291 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa-tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 481 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc 591 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat 1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga 1081 gccagggctg caacttgaag gttttgct (2) INFORMATION FOR SEQ ID N0:2:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 590 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2:
tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc 61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 241 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 421 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt (2) INFORMATION FOR SEQ ID N0:3:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2022 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:3:
atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac 61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag 121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag 181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac 241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc 301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc 361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa 921 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc 981 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg 541 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct 601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct 661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc 721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg 781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg 841 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc 901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc 1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc 1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc 1191 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac 1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc 1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc 1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg 1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa 1491 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg 1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc 1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg 1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac 1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag 1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg 1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg 1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag 1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat 1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc (2) INFORMATION FOR SEQ ID N0:4:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2500 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:9:
gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 291 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 921 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 981 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 591 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1941 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2391 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:5:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2489 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:5:
gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 891 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccaqtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801, ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2091 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2391 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca EPI-109 ~pgp 2901 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2961 ccataaaaat aaatcagttc attt (2) INFORMATION FOR SEQ ID N0:6:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2997 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:6:
gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg 61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 921 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 981 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga 601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 891 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1191 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1681 ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc 1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg 2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca 2391 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt 2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat 2461 taagaattgg ttgccataaa aataaatcag ttcattt (2) INFORMATION FOR SEQ ID N0:7:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 10151 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:7:
l cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 241 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 981 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc WO 00!09525 PCT/US99l17712 EPI-109 109!
591 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat 1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga 1081 gccagggctg caacttgaag gttttgct tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc 61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 291 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 921 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac 61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag 121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag 181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac 241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc 301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc 361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa 421 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc 981 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg 591 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct 601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct 661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc 721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg 781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg 891 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc 901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc 1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc 1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc 1141 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac 1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc 1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc 1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg 1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa 1991 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg 1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc 1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg 1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac 1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag 1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg 1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg 1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag 1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat 1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 591 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 891 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2091 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1491 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1791 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2391 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg EPI-109 ~ pg3 2461 ccataaaaat aaatcagttc attt gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg 61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 421 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 481 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga 601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 841 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1141 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1681 ccgcctccgc ccagcacgcc gcggtcaacG tcggccagta cgactggtgc tcctggatcc 1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg 2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca 2341 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt 2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat 2961 taagaattgg ttgccataaa aataaatcag ttcattt (2) INFORMATION FOR SEQ ID N0:8:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2383 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:8:
ggcacgaggc tggctgagcc atgatgctgc tgccagaacc cctgcagagg gcctggtttc 61 aggagactca gagtcctctg tgaaaaagcc cttggagagg cgccccagca gggctgcact 121 tggctcctgt gaggaagggg ctcagggtct gggcccctcc gcctgggccg ggctgggagc 181 caggcgggcg gctgggctgc agcaatggac cgtgagctgg cccagcccgc gtccgtgctg 241 agcctgcctg tcgtctgtgg ccatgccatc atgggctcct cggtgtacat cacggtggag 301 ctggccattg ctgtgctggc catcctgggc aatgtgctgg tgtgctgggc cgtgtggctc 361 aacagcaacc tgcagaacgt caccaactac tttgtggtgt cactggcggc ggccgacatc 921 gcagtgggtg tgctcgccat cccctttgcc atcaccatca gcaccgggtt ctgcgctgcc 481 tgccacggct gcctcttcat tgcctgcttc gtcctggtcc tcacgcagag ctccatcttc 541 agtctcctgg ccatcgccat tgaccgctac attgccatcc gcatcccgct ccggtacaat 601 ggcttggtga ccggcacgag ggctaagggc atcattgcca tctgctgggt gctgtcgttt 661 gccatcggcc tgactcccat gctaggttgg aacaactgcg gtcagccaaa ggagggcaag 721 aaccactccc agggctgcgg ggagggccaa gtggcctgtc tctttgagga tgtggtcccc 781 atgaactaca tggtgtactt caacttcttt gcctgtgtgc tggtgcccct gctgctcatg 841 ctgggtgtct atttgcggat cttcctggcg gcgcgacgac agctgaagca gatggagagc 901 cagcctctgc cgggggagcg ggcacggtcc acactgcaga aggaggtcca tgctgccaag 961 tcactggcca tcattgtggg gctctttgcc ctctgctggc tgcccctaca catcatcaac 1021 tgcttcactt tcttctgccc cgactgcagc cacgcccctc tctggctcat gtacctggcc EPI-109 )094 1081 atcgtcctct cccacaccaa ttcggttgtg aatcccttca tctacgccta ccgtatccgc 1141 gagttccgcc agaccttccg caagatcatt cgcagccacg tcctgaggca gcaagaacct 1201 ttcaaggcag ctggcaccag tgcccgggtc ttggcagctc atggcagtga cggagagcag 1261 gtcagcctcc gtctcaacgg ccacccgcca ggagtgtggg ccaacggcag tgctccccac 1321 cctgagcgga ggcccaatgg ctatgccctg gggctggtga gtggagggag tgcccaagag 1381 tcccagggga acacgggcct cccagacgtg gagctcctta gccatgagct caagggagtg 1441 tgcccagagc cccctggcct agatgacccc ctggcccagg atggagcagg agtgtcctga 1501 tgattcatgg agtttgcccc ttcctaaggg aaggagatct ttatctttct ggttggcttg 1561 accagtcacg ttgggagaag agagagagtg ccaggagacc ctgagggcag ccggttccta 1621 ctttggactg agagaaggga gccccaggct ggagcagcat gaggcccagc aagaagggct 1681 tgggttctga ggaagcagat gtttcatgct gtgaggcctt gcaccaggtg ggggccacag 1741 caccagcagc atctttgctg ggcagggccc agccctccac tgcagaagca tctggaagca 1801 ccaccttgtc tccacagagc agcttgggca cagcagactg gcctggccct gagactgggg 1861 agtggctcca acagcctcct gccacccaca caccactctc cctagactct cctagggttc 1921 aggagctgct gggcccagag gtgacatttg acttttttcc aggaaaaatg taagtgtgag 1981 gaaacccttt ttattttatt acctttcact ctctggctgc tgggtctgcc gtcggtcctg 2041 ctgctaacct ggcaccagag cctctgccgg ggagcctcag gcagtcctct cctgctgtca 2101 cagctgccat ccacttctca gtcccagggc catctcttgg agtgacaaag ctgggatcaa 2161 ggacagggag ttgtaacaga gcagtgccag agcatgggcc caggtcccag gggagaggtt 2221 ggggctggca ggccactggc atgtgctgag tagcgcagag ctacccagtg agaggccttg 2281 tctaactgcc tttccttcta aagggaatgt ttttttctga gataaaataa aaacgagcca 2341 catcgtgttt taagcttgtc caaatgaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID N0:9:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2988 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:9:
L catcaccttt ttttaagtag taagaataaa gccactgtat gattctctta atagctatac 61 attaatcctg tttttagtgc tgactgggcc agccttccgg gaactggagt ctgtctcttt 121 cagtgctttt ttgttttttg ttggtttttt cgagacgggg tcgatcacgg ctcaccacag 181 ccttaacctc cagggctcca gcaatcctcc cacctcagcc tcctgagtag ctgggaccac 241 aggtgtgtgc caccatctcc agcagtttgt ttatttattt tttctttttt tttttttggt 301 agaaatgggc ttttcgccca tgttgcccaa gctggtcttg cacttctggg ctgaagcaat 361 cctctcgcct tggcctccca gagccttggg attacagaat catgggtgag agctggcatg 421 gcccctagag gtcatttggg gtccagctgc ctcaccgtat caatgaggaa actgaggccc 481 agaaaagaaa agcatttttg cccagagtcc ctcagaaaaa aacagaccac atctgatcct 541 tggccctgag tccagagtgg gaggcaccgt gacaacaatg cgcagagcag ggaatgcagg 601 gagccatgga tagtgctggg gtgcctcagg aaccctgaag ctgggctgag ccatgatgct 661 gctgccagaa cccctgcaga gggcctggtt tcaggagact cagagtcctc tgtgaaaaag 721 cccttggaga gcgccccagc agggctgcac ttggctcctg tgaggaaggg gctcaggggt 781 ctgggcccct ccgcctgggc cgggctggga gccaggcggg cggctgggct gcagcaatgg 841 accgtgagct ggcccagccc gcgtccgtgc tgagcctgcc tgtcgtctgt ggcatgccca 901 tcatgggctc ctcggtgtac atcacggtgg agctggccat tgctgtgctg gccatcctgg 961 gcaatgtgct ggtgtgctgg gccgtgtggc tcaacagcaa cctgcagaac gtcaccaact 1021 actttgtggt gtcactggcg gcggccgaca tcgcagtggg tgtgctcgcc atcccctttg 1081 ccatcaccat cagcaccggg ttctgcgctg cctgccacgg ctgcctcttc attgcctgct 1191 tcgtcctggt cctcacgcag agctccatct tcagtctcct ggccatcgcc attgaccgct 1201 acattgccat ccgcatcccg ctccggtaca atggcttggt gaccggcacg agggctaagg 1261 gcatcattgc catctgctgg gtgctgtcgt ttgccatcgg cctgactccc atgctaggtt 1321 ggaacaactg cggtcagcca aaggagggca agaaccactc ccagggctgc ggggagggcc 1381 aagtggcctg tctctttgag gatgtggtcc ccatgaacta catggtgtac ttcaacttct 1441 ttgcctgtgt gctggtgccc ctgctgctca tgctgggtgt ctatttgcgg atcttcctgg 1501 cggcgcgacg acagctgaag cagatggaga gccagcctct gccgggggag cgggcacggt 1561 ccacactgca gaaggaggtc catgctgcca agtcactggc catcattgtg gggctctttg 1621 ccctctgctg gctgccccta cacatcatca actgcttcac tttcttctgc cccgactgca 1681 gccacgcccc tctctggctc atgtacctgg ccatcgtcct ctcccacacc aattcggttg 1741 tgaatccctt catctacgcc taccgtatcc gcgagttccg ccagaccttc cgcaagatca 1801 ttcgcagcca cgtcctgagg cagcaagaac ctttcaaggc agctggcacc agtgcccggg 1861 tcttggcagc tcatggcagt gacggagagc aggtcagcct ccgtctcaac ggccacccgc 1921 caggagtgtg ggccaacggc agtgctcccc accctgagcg gaggcccaat ggctatgccc 1981 tggggctggt gagtggaggg agtgcccaag agtcccaggg gaacacgggc ctcccagacg 2091 tggagctcct tagccatgag ctcaagggag tgtgcccaga gccccctggc ctagatgacc 2101 ccctggccca ggatggagca ggagtgtcct gatgattcat ggagtttgcc ccttcctaaq 2161 ggaaggagat ctttatcttt ctggttggct tgaccagtca cgttgggaga agagagagag 2221 tgccaggaga ccctgagggc agccggttcc tactttggac tgagagaagg gagccccagg 2281 ctggagcagc atgaggccca gcaagaaggg cttgggttct gaggaagcag atgtttcatg 2391 ctgtgaggcc ttgcaccagg tgggggccac agcaccagca gcagcatctt tctgggcagg 2401 cccagccctc cactgcagaa gcatctggaa gcaccacctt gtctccacag agcagcttgg 2961 gcacagcaga ctggcctggc cctgagactg gggagtggct ccaacagcct cctgccaccc 2521 acacaccact ctccctagac tctcctaggg ttcaggagct gctgggccca gaggtgacat 2581 ttgacttttt tccaggaaaa atgtaagtgt gaggaaaccc cttttatttt attacctttc 2641 actctctggc tgctgggtct gccgtcggtc ctgctgctaa cctggcagca gagcctctgc 2701 ccggggagcc tcaggcagtc ctctcctgct gtcacagctg ccatccactt ctcagtccca 2761 gggccatctc ttggagtgac aaagctggga tcaaggacag ggagttgtaa cagagcagtg 2821 ccagagcatg ggcccaggtc ccaggggaga ggttggggct ggcaggccac tggcatgtgc 2881 tgagtagcgc agagctaccc agtgagaggc cttgtctaac tgcctttcct tctaaaggga 2941 atgttttttt ctgagataaa ataaaaacga gccacatcgt gttttaag (2) INFORMATION FOR SEQ ID N0:10:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2157 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:10:
ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 291 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 4B1 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1191 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:11:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 999 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: 5EQ ID NO:11:
agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat 61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 291 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg 361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 421 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 591 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc (2) INFORMATION FOR SEQ ID N0:12:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 3739 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:12:
cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc 61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg 121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg 181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg 291 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc 301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact 361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc 921 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct 981 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat 541 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat 601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg 661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct 721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg 781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca 841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc 901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag 961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc 1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca 1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag 1141 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg 1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt 1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa 1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct 1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg 1941 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga 1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg 1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa 1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt 1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca 1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga 1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata 1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg 1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg 1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2901 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2991 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361 taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatag tcccagctac ttgggaggct aaagtggaag gattagttga 3981 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3591 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc (2) INFORMATION FOR SEQ ID N0:13:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 4683 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:13:
agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat 61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 291 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg 361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 921 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 541 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc 61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg 121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg 181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg 241 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc 301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact 361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc 421 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct 481 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat 591 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat 601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg 661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct 721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg 781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca 841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc 901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag 961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc 1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca 1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag 1191 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg 1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt 1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa 1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct 1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg 1941 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga 1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg 1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa 1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt 1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca 1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga 1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata 1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg 1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg EPi-l09 ~ 1098 1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2901 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2941 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361~taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatat~ tcccagctac ttgggaggct aaagtggaag gattagttga 3981 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3541 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc (2) INFORMATION FOR SEQ ID N0:19:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2156 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: 5EQ ID N0:19:
1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 921 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 591 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1791 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2091 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:15:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2955 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:15:
gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca 61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt 121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag 181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct 241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg 301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa 361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg 921 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat 481 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc 591 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc 601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca 661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc 721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt 781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg 891 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg 901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga 961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca 1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc 1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca 1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa 1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg 1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag 1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa 1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt 1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta 1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc 1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa 1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt 1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt 1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca 1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc 1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct 1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag 1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt 2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta 2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg 2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact 2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga 2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa 2341 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc 2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg 2961 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag 2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa 2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca 2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt 2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac 2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg 2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta 2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa 2941 cccagacacc tcctg (2) INFORMATION FOR SEQ ID N0:16:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1995 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/177~2 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:16:
atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat 61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 291 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag 361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 981 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 591 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 841 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc 901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg 961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc 1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag 1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc 1191 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat 1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc 1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt 1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa 1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact 1441 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga (2) INFORMATION FOR SEQ ID N0:17:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 6606 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:17:
ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 291 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 981 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1991 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa 1 gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca 61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt 121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag 181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct 241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg 301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa 361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg 921 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat 981 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc 591 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc 601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca 661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc 721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt 781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg 891 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg 901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga 961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca 1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc 1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca 1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa 1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg 1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag 1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa 1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt 1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta 1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc 1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa 1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt 1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt 1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca 1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc 1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct 1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag 1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt 2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta 2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg 2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact 2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga 2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa 2391 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc 2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg 2961 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag 2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa 2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca 2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt 2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac 2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg 2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta 2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa 2941 cccagacacc tcctg 1 atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat 61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 291 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag 361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 981 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 591 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 891 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc EPt-109 1102 901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg 961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc 1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag 1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc 1191 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat 1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc 1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt 1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa 1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact 1991 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga (2) INFORMATION FOR SEQ ID N0:18:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1068 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:18:
atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 541 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 841 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag (2) INFORMATION FOR SEQ ID N0:19:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:19:
tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac 61 ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag 121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt 181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa 241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg 301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc 361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga 421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg 981 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat 541 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga 601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct 661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc 721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat 781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg 841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc 901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa 961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt 1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga 1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag 1191 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag 1201 t (2) INFORMATION FOR SEQ ID N0:20:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1699 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:20:
aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct 61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga 121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa 181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 241 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 421 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 481 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 541 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 891 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac 1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa 1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca 1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat 1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct 1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt 1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta 1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca 1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat 1681 gaaaagctt (2) INFORMATION FOR SEQ ID N0:21:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2968 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:21:
atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 591 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 891 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac 61'ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag 121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt 181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa 241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg 301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc 361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga 421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg 981 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat 591 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga EPl-109 1104 601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct 661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc 721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat 781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg 841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc ' 901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa 961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt 1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga 1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag 1191 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag 1201 t 1 aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct 61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga 121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa 181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 291 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 921 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 981 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 591 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 841 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac 1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa 1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca 1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat 1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct 1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt 1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta 1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca 1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat 1681 gaaaagctt (2) INFORMATION FOR SEQ ID N0:22:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:22:
tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc 61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga 121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg 181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca 291 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa 301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct 361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta 421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat 481 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta 541 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt 601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc 661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct 721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag 781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga 841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaactgttc tctgattctt 901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc 961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac 1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta 1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac 1141 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt 1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag EPl-109 1105 1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctctca aaagaaagat 1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctac~a aggagaacta 1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg 1491 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata 1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag 1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg 1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc 1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca 1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg 1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa 1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg 1921 gccatttcac tctgactaca tcatgtcacc aaacatctga tggtcttg:~.c ttttaattct 1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgcaggct tcccgcattc 2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc 2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat 2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga 2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg 2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctcatgcc tgtaatccca 2391 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagttcgag accagcctgg 2901 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagcttggt gtggtggcgc 2461 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc 2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g (2) INFORMATION FOR SEQ ID N0:23:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 3383 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:23:
agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat 61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa 121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc 181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag 291 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact 301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa 361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg 421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc 481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca 591 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt 601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg 661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt 721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt 781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa 891 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca 901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag 961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa 1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc 1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca 1141 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga 1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg 1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa 1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac 1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt 1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa 1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc 1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg 1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg 1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat 1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg 1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt 1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg qtgttgcaga 1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca 1981 ccaacagccc tcaggtca,:g gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg 2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat 2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga 2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt gaacacactc tcacccagac tccaggctgt ctttcactga atgcttctga 2391 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2901 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2961 ggtgaggatt gattacc~ag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaagg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2991 caaagggaga gagagagctt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID N0:24:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 193068 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:29:
aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 591 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 891 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1791 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2091 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2391 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2691 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatt~aa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2991 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccat:ca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3921 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3891 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 9021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccaacct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 9381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4491 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 9501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 9621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 9681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5091 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5391 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5901 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5691 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6291 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6921 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6981 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6891 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgaca~aaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7191 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8091 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8901 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8961 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8691 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8991 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc 9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9981 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9591 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10491 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10741' cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattc~tag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc EPI-l09 1109 11391 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11961 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12591 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13191 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13491 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 19041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 19221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 19281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 19341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 19961 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 19521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14691 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 19761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 19821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 19941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15291' attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15921 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15891 atgtagagat aaggggc~at gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggaga~at taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagc~tt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaac~ga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattc~ga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcct~ga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt ggggggg=as agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgsga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcacctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttt=at ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17091 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17691 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18591 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19491 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt EPI-l09 1111 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20901 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20961 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20691 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21291 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21921 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21981 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct 21891 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22491 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22791 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23091 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23391 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 29291 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 29421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 29481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 29591 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 29601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 29661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 29901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 29961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25191 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttt~gcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26391 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26901 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27981 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28941 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29091 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29901 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29961 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29691 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29991 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30921 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30981 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30591 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31791 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32901 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32?61 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32991 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 3329T gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33981 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta EPi-109 1114 33891 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 39081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 39191 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 39201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 39261 tggacatttg gqttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 39321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 39491 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 39561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 39621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 39741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 39802 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 39981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35391 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35901 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct 35961 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35691 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36291 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36591 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37791'ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct WO 00/09525 PCT/US99/17?12 38391 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38961 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39921 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39591 tttgatcctt ctagctgtta aggaagaaaa aaataatttt-ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 90321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 90381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 90941 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 90501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 90561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 90621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 90681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 90741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 90801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41091 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41391 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41901 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41961 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 91641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 91761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 91821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42291 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 92921 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 92661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac EPf-109 1116 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagat~aga ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacg~~aa agagctggaa 93081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43191 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 93201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 93261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 93321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43941 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcc~cc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 43791 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 93801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatL:.ga gcaggaggta 93861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 93981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 94101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 49161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 49221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc 49391 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 49401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 99961 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 49521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 94581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 99701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 49821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 94881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 99941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 95121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 45291 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaacta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 95421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 95541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 95601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 95661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 95781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45891 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggaLtg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46191 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 96501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 96621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 96741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 96801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 96861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 97041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 97101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 97161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 97281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47391 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 97901 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 97961 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 97581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 97641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 98001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 98061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 98181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 98291 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48921 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 98481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 98601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 98661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 98781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 98901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 99141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 99321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 99941 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 99681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 99801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 99861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 99921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50091 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctq 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51291 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51921 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51981 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51591 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51891 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctc~;c ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52191 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52941 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52791 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53091 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53961 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53691 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 59061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 59181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 59241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 59921 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54981 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54591 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 59661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 59781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 59841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 59961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55941 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741' ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt EPI-109 ilt9 56391 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56901 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57981 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc.acagagcttc aataatttgg 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59091 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59991 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241' ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60921 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggc~tgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactcagttg cagctgggca EPI~109 1120 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61491 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61791 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62091 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg 62391 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62991 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63591 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 69021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 69381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 69991 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 69501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 69621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 69791 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65901 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65961 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65691 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66921 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67191 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67491 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68391 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69291 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag EPl-109 1122 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70941 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70791 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71391 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71691 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71991 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72291 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72921 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72981 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72891 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73191 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73791'tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 79221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca WO 00/09525 PCf/US99/17712 79341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctct~~ct ccagggttca 74901 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74961 tagctaattt tttgtatttt cagtagagat ggggtttcac catatt~tat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 79641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 79701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 79761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 79881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 79991 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75291 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75921 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag 75891 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76941 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77901 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77961 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77991 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181. gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78921 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccct~tga gtaaagatgt 78591 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79191 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac~agatgggaca ttccttggcc cagtggccag 79791 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80091 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80961 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80691 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81591 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83091 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83961 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83691 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 89001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 89061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 89181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 89291 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 89301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 89421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 89981 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 84591 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 89661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 89721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 89781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact 89841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 89901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 89961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85991 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85791 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86691 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87291 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87891 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88191 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc 89391 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89961 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89691 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89991 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90981 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90891 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa EPt-109 1127 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctg_c~=ggt gtcggcaaaa 92901 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaa~tca gccaaaagaa 92961 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaqgagaaat gttta:~ggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggc7ata aatcagtaac 92691 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgt:~~ca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaac=~ttg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctc=ctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacc:.cctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg caccca~cgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgcct:ctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93921 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt 93891 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgt~ttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagtctg acttgacttt 99021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 99081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctycct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 99381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 94991 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 99741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 99981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcc~ccc accattccaa 95091 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccc:ttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95691 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccac~gtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96291 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96981 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gctta~~ctg gtaaaatata 96891 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97191 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97941 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98091 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98391 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98901 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98691 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt 99291 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat 99981 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg 99891 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100941 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100791 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa EPI-! 09 1129 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101901 ccacttctcc ~cctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101961 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102291 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102921 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag 102981 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102591 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103191 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 109091 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 109161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 109391 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 109521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105247. cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105981 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105591 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact WO 00/09525 PCf/US99/17712 105891 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctcgycaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcat~~aga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatc~~gca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttc~agc ccaaactgaa 106191 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106791 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107091 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca 107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107901 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107991 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108921 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108591 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttqgactgc 109191 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110091 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg WO 00/09525 PC'TNS99/17712 110391 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110961 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttc cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111981 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113961 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113991 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 119241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 119361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114921 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 119481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 119591 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 119661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 119891 atggaaaatg gtaggttwga ttttatgact gaagtggcaa aaagaaataa gggattttat 119901 tatgggggag g:ccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115791 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116391 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116901 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116961 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116691 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116991 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117291 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117591 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117891 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118491 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119091 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt 119391 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119901 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119691 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120291 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120591 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122091 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122391 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122961 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123591 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac EPl-109 I 134 123841 cagacactcc caacagggca agttcatcta actatgtgct cttagt~aga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 129021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 129201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 129261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 129381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 129941 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 129621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124791 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 129801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125391 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125961 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125991 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126291 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126591 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126891 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127191 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127941 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128391 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128961 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128691 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128991 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129591 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129891 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130191 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130791 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131091 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131961 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131991 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132241' agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132921 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132981 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132591 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133191 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgc~c cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133941 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 139041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 139101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 139281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 139341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 139961 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 139521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134691 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 139761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 139881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135981 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135591 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136191 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136991 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc EPl-109 1137 137341 aggcccccgt ggcctct:.tg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137691 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138291 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138921 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139191 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 190041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 190101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 190161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 190641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 190701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 190761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 190941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 191181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141291' aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 191541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 191721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 191781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa WO 00/09525 PC'T/US99/17712 EPI-109 p 3g 191891 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaa~~at gaaagtcaaa 191901 aatacttcta actgaagttg tggggaaatt agaacacttg cagag~~~ca ttccagacag 191961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccc=ggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgat~gtc ctaggtgaat 192081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggt~~gtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtg~aat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccacta;tcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccag~agg gacgctgtcc 192321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 192381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgta~aca acaataccga 192501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcagga=~tc taatgctcac 192561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 192681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactga~cat ttaaaatatg 192791 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID N0:25:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 199912 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:25:
tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc 61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga 121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg 181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca 241 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa 301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct 361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta 421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat 981 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta 591 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt 601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc 661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct 721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag 781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga 841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaact7ttc tctgattctt 901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc 961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac 1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta 1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac 1191 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt 1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag 1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctctca aaagaaagat 1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctgcta aggagaacta 1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg 1941 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata 1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag 1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg 1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc 1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca 1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg 1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa 1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg 1921.gccatttcac tctgactaca tcatgtcacc aaacatctga tggtct~gcc ttttaattct 1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgca:,gct tcccgcattc 2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc 2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat 2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga 2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg 2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctca~gcc tgtaatccca 2341 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagtt:.gag accagcctgg 2901 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagct~ggt gtggtggcgc 2961 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc 2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat 61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa 121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc 181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag 241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact 301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa 361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg 421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc 481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca 591 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt 601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg 661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt 721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt 781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccagqaa 891 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca 901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag 961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa 1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc 1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca 1191 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga 1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg 1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa 1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac 1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt 1941 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa 1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc 1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg 1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg 1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat 1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg 1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt 1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg gtgttgcaga 1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca 1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg 2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat 2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga 2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt gaacacagtc tcacccagac tccaggctgt ctttcactga atgcttctga 2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaggg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2941 caaagggaga gagagaggtt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ~~gaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 921 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 981 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 591 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1941 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2091 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2961 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2691 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3981 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3891 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 9081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 9201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 9501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 9561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 9741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 9861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact gqttcctcat tcctgaagtt 5091 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5901 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5691 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6291 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6921 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7791 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8901 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8691 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8991 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc s f DEMANDES OU BREVETS VOLUMINEUX
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NOTE:.For additional volumes~piease contact'the Canadian Patent Office EPI-I09 845 _ 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggc~aca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2391 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2901 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2691 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcc~ccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 9191 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 9321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 9381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 9441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 9861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 9921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5091 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5901 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID N0:2670:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (e) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2670 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaaqcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1991 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1791 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactqgaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2391 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2961 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3981 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3591 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3891 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961' tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 9021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 9081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4191 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 9321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 9561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 9741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 9921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 9981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5901 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID N0:2671:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2671 1 cgtgttgatg atggagtagc ttcctttgtg cttaatctcc catctggagt gacggtgctg 61 gagtttaatg tcaaaactga tgctccagat cttccagaag aaaatcaggc cagggaaggt 121 taccgagcaa tagcatactc atctctcagc caaagttacc tttatattga ttggactgat 181 aaccataagg ctttgctagt gggagaacat ctgaatatta ttgttacccc caaaagccca 291 tatattgaca aaataactca ctataattac ttgattttat ccaagggcaa aattatccac 301 tttggcacga gggagaaatt ttcagatgca tcttatcaaa gtataaacat tccagtaaca 361 cagaacatgg ttccttcatc ccgacttctg gtctattata tcgtcacagg agaacagaca 421 gcagaattag tgtctgattc agtctggtta aatattgaag aaaaatgtgg caaccagctc 481 caggttcatc tgtctcctga tgcagatgca tattctccag gccaaactgt gtctcttaat 591 atggcaactg gaatggattc ctgggtggca ttagcagcag tggacagtgc tgtgtatgga 601 gtccaaagag gagccaaaaa gcccttggaa agagtatttc aattcttaga gaagagtgat 661 ctgggctgtg gggcaggtgg tggcctcaac aatgccaatg tgttccacct agctggactt 721 accttcctca ctaatgcaaa tgcagatgac tcccaagaaa atgatgaacc ttgtaaagaa 781 attctcaggc caagaagaac gctgcaaaag aagatagaag aaatagctgc taaatataaa 891 cattcagtag tgaagaaatg ttgttacgat ggagcctgcg ttaataatga tgaaacctgt 901 gagcagcgag ctgcacggat tagtttaggg ccaagatgca tcaaagcttt cactgaatgt 961 tgtgtcgtcg caagccagct ccgtgctaat atctctcata aagacatgca attgggaagg 1021 ctacacatga agaccctgtt accagtaagc aagccagaaa ttcggagtta ttttccagaa 1081 agctggttgt gggaagttca tcttgttccc agaagaaaac agttgcagtt tgccctacct 1141 gattctctaa ccacctggga aattcaaggc attggcattt caaacactgg tatatgtgtt 1201 gctgatactg tcaaggcaaa ggtgttcaaa gatgtcttcc tggaaatgaa tataccatat 1261 tctgttgtac gaggagaaca gatccaattg aaaggaactg tttacaacta taggacttct 1321 gggatgcagt tctgtgttaa aatgtctgct gtggagggaa tctgcacttc ggaaagccca 1381 gtcattgatc atcagggcac aaagtcctcc aaatgtgtgc gccagaaagt agagggctcc 1991 tccagtcact tggtgacatt cactgtgctt cctctggaaa ttggccttca caacatcaat 1501 ttttcactgg agacttggtt tggaaaagaa atcttagtaa aaacattacg agtggtgcca 1561 gaaggtgtca aaagggaaag ctattctggt gttactttgg atcctagggg tatttatggt 1621 accattagca gacgaaagga gttcccatac aggataccct tagatttggt ccccaaaaca 1681 gaaatcaaaa ggattttgag tgtaaaagga ctgcttgtag gtgagatctt gtctgcagtt 1791 ctaagtcagg aaggcatcaa tatcctaacc cacctcccca aagggagtgc agaggcggag 1801 ctgatgagcg ttgtcccagt attctatgtt tttcactacc tggaaacagg aaatcattgg 1861 aacatttttc attctgaccc attaattgaa aagcagaaac tgaagaaaaa attaaaagaa 1921 gggatgttga gcattatgtc ctacagaaat gctgactact cttacagtgt gtggaagggt 1981 ggaagtgcta gcacttggtt aacagctttt gctttaagag tacttggaca agtaaataaa 2041 tacgtagagc agaaccaaaa ttcaatttgt aattctttat tgtggctagt tgagaattat 2101 caattagata atggatcttt caaggaaaat tcacagtatc aaccaataaa attacagggt 2161 accttgcctg ttgaagcccg agagaacagc ttatatctta cagcctttac tgtgattgga 2221 attagaaagg ctttcgatat atgccccctg gtgaaaatcg acacagctct aattaaagct 2281 gacaactttc tgcttgaaaa tacactgcca gcccagagca cctttacatt ggccatttct 2341 gcgtatgctc tttccctggg agataaaact cacccacagt ttcgttcaat tgtttcagct 2901 ttgaagagag aagctttggt taaaggtaat ccacccattt atcgtttttg gaaagacaat 2961 cttcagcata aagacagctc tgtacctaac actggtacgg cacgtatggt agaaacaact 2521 gcctatgctt tactcaccag tctgaacttg aaagatataa attatgttaa cccagtcatc 2581 aaatggctat cagaagagca gaggtatgga ggtggctttt attcaaccca ggacacaatc 2641 aatgccattg agggcctgac ggaatattca ctcctggtta aacaactccg cttgagtatg EPI-109 g4g 2701 gacatcgatg tttcttacaa gcataaaggt gccttacata attataaaat gacagacaag 2761 aatttccttg ggaggccagt agaggtgctt ctcaatgatg acctcattgt cagtacagga 2821 tttggcagtg gcttggctac agtacatgta acaactgtag ttcacaaaac cagtacctct 2881 gaggaagttt gcagcttt~a tttgaaaatc gatactcagg atattgaagc atcccactac 2991 agaggctacg gaaactctga ttacaaacgc atagtagcat gtgccagcta caagcccagc 3001 agggaagaat catcatctgg atcctctcat gcggtgatgg acatctcctt gcctactgga 3061 atcagtgcaa atgaagaaga cttaaaagcc cttgtggaag gggtggatca actattcact 3121 gattaccaaa tcaaagatgg acatgttatt ctgcaactga attcgattcc ctccagtgat 3181 ttcctttgtg tacgattccg gatatttgaa ctctttgaag ttgggtttct cagtcctgcc 3241 actttcacag tgtacgaata ccacagacca gataaacagt gtaccatgtt ttatagcact 3301 tccaatatca aaattcagaa agtctgtgaa ggagccgcgt gcaagtgtgt agaagctgat 3361 tgtgggcaaa tgcaggaaga attggatctg acaatctctg cagagacaag aaaacaaaca 3421 gcatgtaaac cagagattgc atatgcttat aaagttagca tcacatccat cactgtagaa 3981 aatgtttttg tcaagtacaa ggcaaccctt ctggatatct acaaaactgg ggaagctgtt 3541 gctgagaaag actctgagat taccttcatt aaaaaggtaa cctgtactaa cgctgagctg 3601 gtaaaaggaa gacagtactt aattatgggt aaagaagccc tccagataaa atacaatttc 3661 agtttcaggt acatctaccc tttagattcc ttgacctgga ttgaatactg gcctagagac 3721 acaacatgtt catcgtgtca agcattttta gctaatttag atgaatttgc cgaagatatc 3781 tttttaaatg gatgctaaaa ttcctgaagt tcagctgcat acagtttgca cttatggact 3841 cctgttgttg aagttcgttt ttttgttttc ttcttttttt aaacattcat agctggtctt 3901 atttgtaaag ctcactttac ttagaattag tggcacttgc ttttattaga gaatgatttc 3961 aaatgctgta actttctgaa ataacatggc cttggagggc atgaagacag atactcctcc 4021 aaggttattg gacaccggaa acaataaatt ggaacacctc ctcaaaccta ccactcagga 9081 atgtttgctg gggccgaaag aacagtccat tgaaagggag tattacaaaa acatggcctt 4141 tgcttgaaag aaaataccaa ggaacaggaa actgatcatt aaagcctgag tttgctttc 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 921 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1991 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041'agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2901 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2961 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt EPI-l09 B49 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2691 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcc~ccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccacaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3291 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3591 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 9141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 9261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 9381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4941 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 9561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 9681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 9981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5391 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 291 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 981 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661'tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1191 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1941 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2691 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3291 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3921 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3891 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 9081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 9141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 9201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 9261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 9321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 9381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4941 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 9501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 9741'tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 9801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 9921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5091 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac WO 00/09525 ~ PCT/US99/17712 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaacLga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID N0:2672:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2672 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1791 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181.tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3921 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3981 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3591 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc WO 00/09525 PCTlUS99/17712 EPLl09 852 3891 aatatcacta cagatcc=ac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctt~aat cccagcactt tgggagggct aggaaggcgg atcacgaggt 9081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 9191 aattagccag gcttggt;gt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 9201 agaattgctt gaacctc~ga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 9261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 9381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 9941 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 9621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 9681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 9791 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 9801 caaqagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 9861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 9981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtqatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctq ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6291 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6981 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6591 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6891 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7191 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7941 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7791 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8091 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tatttt_ctt tttgtatgtg 8901 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8961 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8691 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttaqttc 9121 taacagactt attctatga'a tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc 9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9981 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10191 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaasg gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10491 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10791 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11091 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc 11391 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11961 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11991 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12291 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12981 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 126D1 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12891 atacagaaag ~ggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ~cttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 19041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 19161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 19221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14391 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14901 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 19691 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 19701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14991 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15591 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15891 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattggga ggacacagga catccaatta gagagtgccc aagggggtcc 16191 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttg-a 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17901 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17961 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctagqt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18291 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18921 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19791 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20691 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21291'catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct EPI-f 09 856 21841 ggagagccct taggacct:g tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22191 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22491 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23091 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23901 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23961 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23691 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23991 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 29121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 29181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 29301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 29361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 29921 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 29481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24591 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 29721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 29781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 29901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25191 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25791 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26091 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26341 tqagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26961 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26691 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27921 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27591 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28191 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28491 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28791 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29961 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29691 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29991 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30291 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30921 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30591 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc ~gataatacc tagtactgag ttggagtaat agaaactgct aatgggacag EPI-f 09 g5g 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32961 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33591 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta 33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 39021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 39081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 39321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 39991 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 39621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 39921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35091 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35901 tgcattgaca ctgtaga~ag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36891 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37191 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38091 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38691 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39291 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39981 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctc~ggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 90081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40191 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 90201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 90261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 90941 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 40791 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 90801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 91041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 91221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 91941 aagttaccat gagataggag aaacasgtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 92181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 92301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 92361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 92421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 92541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 92721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 92781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagatgaga ggcaggggtg 92901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 92961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 93141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 93321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 93501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg 93681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 93741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 93801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta 93861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 93921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 93981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 49041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 99161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 94221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 49281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc W O 00/09525 PCTNS99/i 7712 EPI-109 g61 99341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 49461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 94521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 49581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 94641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 99701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 49761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 94821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 94991 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 95061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 95121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 95181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 95241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaatta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 95421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 95981 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 95541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 95601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 95781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 95961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 96201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 96441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 96561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 96621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 96741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 96801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 96861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 96921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 96981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47391 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 97461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47581 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 97641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 97821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 97881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 98121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 98181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 98421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 98981 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 98541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 98661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 98781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48891 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 98901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 99021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 99081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 99141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 99201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 99381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 99941 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtg.cgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49791 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 99921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50091 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcqgagc ttgcagtgag ccgagatcgg 50391 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50901 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50961 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50691 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50991 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51981 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52191 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52491 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat EPI-109 863 _ 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53691 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 59001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 59061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 59301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 59361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54921 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatCt tctagtaagc cctgggagag 59781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 59841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 59901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 59961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55191 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55791 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56091 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56901 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56991 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181, cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57981 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaa't tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg 57891 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58191 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga.gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58991 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59391 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59901 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59961 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttaca ggaa 59691 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggcttgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactgagttg cagctgggca 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61191 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61491 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741'gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg EPI-!09 865 62391 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62691 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63981 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtca ca g 63591 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 69141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 69201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 69621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 69681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 69861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 69921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 69981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65961 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65641 tggagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca ggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66291 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt _ccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa EPI-109 g~
66891 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67191 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67491 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67791 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68091 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68282 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68391 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68961 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68642 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aagqggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69291 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69981 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70491 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70791~tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71091 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71991 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72591 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73191 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg qtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 79281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca 79341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca 79401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 79961 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg 79521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 79701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74991 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241~gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75591 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag EPI-109 868 _ 75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca .
76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76791 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77691 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78291 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79991 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80691 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82491 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82791 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt qtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83991 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 89001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 89181,gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 89241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 89361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 84981 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 89591 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 89601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact EP1-109 g70 84841 ccaatgatga ~ggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 89901 ctcctgtgca cgtgac~~cc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 84961 cattgtggct ~tagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaacct~:.ca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcc:.gt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc ~gctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85491 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaactag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86901 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86961 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcascgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87591 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88941 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagt,g gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc WO 00!09525 PCTNS99/17712 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89901 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89991 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90981 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90591 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90891 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91191 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91491 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa 92391 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92691 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181.tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93921 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93591 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt EPl-109 872 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaag~ctg acttgacttt 99021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 99201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttct.:cct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 99941 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 99621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 99681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 99801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 99921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa 95091 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96291 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96591 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata 96891 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97191 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97991 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgt~cac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741~aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98391 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt 99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99921 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat 99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99591 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg 99891 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100491 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101901 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101961 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101691 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181. agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102421 ttagtataag tacaaccca.t atacgacaat tgcagtattt gttatttatc tgaaattcag 102981 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt ' 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 109041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 109101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 109161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 109221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 109901 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 109461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 109581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 109641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 109701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 109821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104991 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105291 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105591 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact 105891 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106941 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681. tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca EP!-109 875 107391 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107961 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107991 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108291 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108981 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108891 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109991 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcasggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109791 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg 110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110901 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcatttt'c cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111921 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt EPI-109 g~6 111891 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112941 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113391 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113901 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113961 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113691 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113991 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 119001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 119061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 119121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 119541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 119781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 114891 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 119961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115941 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681.cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116091 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116961 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117291 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117921 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117591 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118791 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt 119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119901 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119991 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181,gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120591 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120891 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121491 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122091 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122391 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122901 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa_cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123591 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac 123891 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 129261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 129381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 129991 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 129681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 129922 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 129982 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125391 gagggtggtc ctgacctaca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125901 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126921 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127191 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127791 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128901 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129921 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129841 acagatgtta tcatgttytc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130791 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131091 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggct3tt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131901 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131961 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131991 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132291 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132981 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132591 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133191 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133941 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaaett gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 139101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagct=ctac agcaacaaac 134391 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 139401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 139461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 139521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 139881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135291 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135921 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135891 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136941 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136791 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137091 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc 137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137961 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt etccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcc~gggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138891 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139941 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140091 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 190221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 190281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 190341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 190401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 190761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 190881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 190991 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 191061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141921 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 191541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 191601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 191661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 191721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 191961 cagcttggtg atcctggqtg catgtggggt ctgtctctgg tggccctggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 192081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 192561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681'aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143091 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID N0:2673:
(i) SEQUENCE CHARACTERISTICS:
EPI-109 gg3 (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: s'_ngle (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2673 1 gagctcagaa attcaa~acc agcctgggca aggtagagag acccccatgt ctacaaaaaa 61 taaaaaatga ttagtca~gt gtggtggccc gcacctgtag ttccagctac tcaggacgct 121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac 181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 291 aaccatcaaa atgttt=.:ca cagcagtcac gccattttac atttctgcca gcaatgtgca 301 ccaggcttcc agtttct=ca catcttcact aactcttatt tcctttgctt taaactctaa 361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact 421 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt 481 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt 541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg 601 tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc 661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt 721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg 781 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc 891 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct 901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac 961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa 1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt 1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag 1191 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag 1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg 1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat 1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca 1381 ggctggtctt gattcctygc ttcaagagat gctcttacct ccacctcctg aagcccaaag 1941 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt 1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc 1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc 1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac 1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca 1741 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag 1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact 1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa 1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg 1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg 2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt 2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg 2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta 2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag (2) INFORMATION FOR SEQ ID N0:2674:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2679 1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 181 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 291 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 921 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 481 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 591 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 841 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta 1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga 1191 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc 1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt 1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc 1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt 1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc 1991 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg 1501 gttctttttc ttcggtaggc (2) INFORMATION FOR SEQ ID N0:2675:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2675 1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc 61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc 121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc 181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat 241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac 301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag 361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac 921 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc 981 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgggcc 591 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg 601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa 661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag 721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg 781 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg 891 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc 901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc 1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc 1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt 1141 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac 1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc 1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg 1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata 1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc 1441 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac 1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc 1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag 1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt 1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc 1741 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag 1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc 1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc 1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag 1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc 2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg 2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg 2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc 2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg 2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc 2341 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca 2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag 2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag 2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac 2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct 2641 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg 2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa 2761 aaaataaaac ttcaat (2) INFORMATION FOR SEQ ID N0:2676:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2676 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 921 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 981 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 591 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1941 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1791 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID N0:2677:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2677 1 gagctcagaa attcaagacc agcctgggca aggtagagag acccccatgt ctacaaaaaa 61 taaaaaatga ttagtcaggt gtggtggccc gcacctgtag ttccagctac tcaggacgct 121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac 181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 241 aaccatcaaa atgttttgca cagcagtcac gccattttac atttctgcca gcaatgtgca 301 ccaggcttcc agtttcttca catcttcact aactcttatt tcctttgctt taaactctaa 361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact 921 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt 4B1 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt 541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg 601,tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc 661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt 721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg 7B1 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc 891 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct 901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac 961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa 1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt 1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag 1191 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag 1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg 1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat 1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca 1381 ggctggtctt gattcctggc ttcaagagat gctcttacct ccacctcctg aagcccaaag 1941 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt 1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc 1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc 1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac 1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca 1791 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag 1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact 1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa 1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg 1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg 2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt 2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg 2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta 2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag 1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 1B1 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 241 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 421 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 981 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 541 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 891 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta 1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga 1141 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc 1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt 1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc 1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt 1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc 1441 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg 1501 gttctttttc ttcggtaggc 1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc 61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc 121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc 181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat 241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac 301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag 361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac 921 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc 481 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgqgcc 541 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg 601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa 661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag 721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg 7B1 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg B41 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc 901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc 1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc 1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt 1191 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac 1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc 1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg 1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata 1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc 1491 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac 1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc 1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag 1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt 1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc 1791 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag 1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc 1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc 1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag 1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc 2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg 2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg 2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc 2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg 2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc 2391 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca 2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag 2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag 2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac 2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct 2691 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg 2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa 2761 aaaataaaac ttcaat 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 18i ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 922 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 591 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1191 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1941 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2091 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID N0:2678:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2678 1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 291 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 9B1 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 591 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gqgggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1191 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaa.g cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt (2) INFORMATION FOR SEQ ID N0:2679:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2679 1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct 61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg 121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg 181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg 291 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga 301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca 361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg 481 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 591 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc 781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg 1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc 1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg 1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc 1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac 1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg 1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat 1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa 1441,gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct 1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt (2) INFORMATION FOR SEQ ID NO:2680:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2680 EPI-l09 889 1 ggaattcc~g gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 291 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 921 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcct~tt cacgggaact 1941 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt 1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct 61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg 121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg 181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg 241 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga 301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca 361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg 981 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 541 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc 781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg 1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc 1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg 1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc 1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac 1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg 1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat 1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa 1491 gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct 1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt (2) INFORMATION FOR SEQ ID N0:2681:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENC~ DESCRIPTION: SEQ ID N0:2681 1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag 61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa 121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa 181 cttttttcct ~atgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc 241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc 301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt 361 ttaaaataat ctaaatataa ttattcctta tgccctgttt ttccctcact tttgtatcca 421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca 981 cttcaaaatg aattcaggat tgtaatgtaa aattttagta ctctctcaca gtatggattc 541 taacatggct tctaacccaa actaacatta gtagctctaa ctataaactt caaatttcag 601 tagatgcaac ctactcc~tt aaaatgaaac agaagattga aattattaaa ttatcaaaaa 661 gaaaatgatc cacgctctta gttgaaattt catgtaagat tccatgcaat aaataggagt 721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg 781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa 891 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg 901 tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt 961 aggacataac tgaattttct attttccact tcttttctgg tgtgtgtgta tatatatatg 1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc 1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc 1141 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa 1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat 1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac 1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc 1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc 1441 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc 1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt 1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc 1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt 1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca 1741 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct 1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga 1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga 1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc 1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg 2041 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg 2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc 2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga 2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg 2281 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac 2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc (2) INFORMATION FOR SEQ ID N0:2682:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2682 1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca 61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct 121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa 181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg 241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa 301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt 361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca 421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt 981 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc 541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct 601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc 661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa 721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg 781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta 891 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca 901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc 961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga 1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa 1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga 1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa 1201.caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata 1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt 1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc 1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc 1941 ttttaatgag taccgcaaac gctttatgct. gaagccctat gaatcatttg aagaacttac 1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga 1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat 1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc 1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc 1791 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt 1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact 1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa 1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt 1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2901 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata 2691 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2991 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag (2) INFORMATION FOR SEQ ID N0:2683:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2683 1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta 61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt 121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc 181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag 241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta 301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac 361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct 921 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc 981 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca 591 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga 601 caggagagtg gggactaccc cctctgctcc caaattgggg cagcttcctg ggtttccgat 661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaa gg 721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac 781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca 841 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag 901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg 961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg 1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc 1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact 1141 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca 1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa 1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata 1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt 1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg 1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat 1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta 1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg 1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt 1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat 1791 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg 1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg 1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga 1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca 1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatttctcc ctccctttct 2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttytga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagttt~cct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccattaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2991 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3291 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3421 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3981 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattc_ttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3891 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 9081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 4201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 9321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 9381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 9441 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 9501 taacttttta actgatgttt atttatttat ttattttttt agataattga tggagagatg 4561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 9681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4741 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 9801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 9921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 4981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5041 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat tccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5341 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5901 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5961 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581'tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5641 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6241 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6921 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6481 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6591 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc 6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact 6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc 6891 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg 6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt 6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta 7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat 7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa 7141 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga 7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg 7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt 7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat 7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa 7491 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt 7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa 7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc 7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca 7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag 7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc 7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta 7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg 7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc 7981 tgttgtacag tttaatttag cagtccatat cacattgcaa aagtagcaat gacctcataa 8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc 8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc 8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg 8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct 8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag 8341 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa 8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga 8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt 8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc 8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg 8641 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt 8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata 8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta 8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg 8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa 8991 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt 9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt 9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt 9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt 9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa 9241 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg 9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta 9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa 9921 aaaaaaaaaa aaaaatcgat gtcgactcga gtc (2) INFORMATION FOR SEQ ID N0:2689:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2684 1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag 61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa 121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa 181 cttttttcct tatgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc 241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc 301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt 361 ttaaaataat ctaaata~aa ttattcctta tgccctgttt ttccctcact tttgtatcca 421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca 481 cttcaaaatg aattcac~at tgtaatgtaa aattttagta ctctctcaca gtatggattc 541 taacatggct tctaacc:.aa actaacatta gtagctctaa ctataaactt caaatttcag 601 tagatgcaac ctactcc~tt aaaatgaaac agaagattga aattattaaa ttatcaaaaa 661 gaaaatgatc cacgctc~ta gttgaaattt catgtaagat tccatgcaat aaataggagt 721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg 781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa 841 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg 901 tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt 961 aggacataac tgaattt~ct attttccact tcttttctgg tgtgtgtgta tatatatatg 1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc 1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc 1191 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa 1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat 1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac 1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc 1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc 1941 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc 1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt 1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc 1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt 1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca 1791 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct 1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga 1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga 1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc 1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg 2091 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg 2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc 2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga 2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg 228 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac 2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc 1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca 61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct 121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa 181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg 291 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa 301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt 361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca 921 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt 481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc 591 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct 601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc 661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa 721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg 781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta 891 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca 901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc 961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga 1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa 1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga 1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa 1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata 1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt 1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc 1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc 1491'ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac 1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga 1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat 1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc 1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc 1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt 1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact 1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa 1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt 1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2901 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttt:.cac caagagtata 2691 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2991 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag 1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta 61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt 121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc 181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag 241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta 301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac 361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct 921 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc 481 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca 541 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga 601 caggagagtg gggactaccc cctctgctcc caaattgggg cagcttcctg ggtttccgat 661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaagg 721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac 781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca 891 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag 901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg 961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg 1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc 1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact 1191 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca 1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa 1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata 1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt 1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg 1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat 1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta 1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg 1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt 1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat 1741 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg 1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg 1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga 1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca 1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatt:ctcc ctccctttct 2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttgtga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagtttgcct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccattaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca EPI-l09 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2941 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3241 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3921 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3481 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattctttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3841 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 9081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 9201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 9321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 9381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 4491 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 9501 taacttttta actgatgttt atttatttat ttattttttt agataattga tggagagatg 9561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 4681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4791 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 9801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 4921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 9981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5091 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat ~ccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5391 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5401 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5961 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581 tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5691 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6291 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6921 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6981 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6541 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc 6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact 6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc 6891 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg 6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt 6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta 7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat 7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa 7191 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga 7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg 7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt 7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat 7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa 7941 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt 7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa 7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc 7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca 7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag 7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc 7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta 7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg 7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc 7981 tgttgtacag tttaatttag cagtccatat cacattgcaa.aagtagcaat gacctcataa 8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc 8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc 8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg 8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct 8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag 8391 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa 8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga 8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt 8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc 8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg 8691 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt 8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata 8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta 8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg 8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa 8991 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt 9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt 9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt 9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt 9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa 9291 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg 9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta 9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa 9921 aaaaaaaaaa aaaaatcgat gtcgactcga gtc (2) INFORMATION FOR SEQ ID N0:2685:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2685 1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 921 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 981 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga 661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc EPI-109 g9g 841 tgctagggat gttagacgga attcc (2) INFORMATION FOR SEQ ID N0:2686:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2686 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc (2) INFORMATION FOR SEQ iD N0:2687:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2687 1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 981 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 591 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 841 ttaataaaaa a (2) INFORMATION FOR SEQ ID N0:2688:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2688 1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg 61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga 121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt 181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa 241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag 301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa 361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg 421 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt 981 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag 591 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa 601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt 661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg 721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact 781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag (2) INFORMATION FOR SEQ ID N0:2689:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single ('D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2689 1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat 61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc 181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt 241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc &PI-109 899 _ 421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag 481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc 901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc 1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc 1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg 1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg 1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc 2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2391 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2901 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2691 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca 3061 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3921 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 9021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 9081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 9191 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 9201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 9321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 9941 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac EPI-109 900 _ 4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 9681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4791 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 9861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 9921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 9981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5091 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5961 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5691 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5991 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt qtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6981 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t (2) INFORMATION FOR SEQ ID N0:2690:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2690 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca 291 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 541 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc (2) INFORMATION FOR SEQ ID N0:2691:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2691 1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 921 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 481 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga 661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc 841 tgctagggat gttagacgga attcc 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc 1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 481 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 541 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 841 ttaataaaaa a 1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg 61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga 121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt 181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa 241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag 301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa 361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg 921 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt 481 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag 541 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa 601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt 661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg 721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact 781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag 1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat 61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc 181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt 241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc 421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag 481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 891 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc 901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc 1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc 1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1191 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1941 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg EPl-109 902 _ 1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1621 gcagacgcca ccgccgagca aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 2681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg.
1791 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc 2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2991 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3061 a~catcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca g gggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3291 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 9081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 9141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 9261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 9991 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac 9501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 9561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 9681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 9921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5091 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5162 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5691 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6291 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6921 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6981 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca 291 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 591 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc (2) INFORMATION FOR SEQ ID N0:2692:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2692 1 gatctgtcta gggctgtcag tggagtattg aagtccccca cgattattgt gttactgtct 61 atctcatttc ttaggtctat taataacagg tttttttgtt ttgttttgtt ttgttttgtt 121 tttttgagat ggagttttgc tcttgttgcc caggctggag tgcaatggca tgatctcagc 181 tcactgcaac ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagcagc 291 tgggactaca ggcatgcacc accacacctg gctaattttg tatttttagt agagacaagg 301 gttctccatg ttggtcaggc tggtcttgaa ctcccgacct ctggtgatct tcccacctca 361 gcctcccaaa gcgctgggat tacaggcatg agccaccgtg cccggcccat agtaactgtt 921 ttataaattt gggagctcca gtgtttagta catatatgtt tagaattgtg atatttccct 981 gttggacaag gccttttacc attatataat gccctctttt gtctctttta gctgctgttg 541 ctttaaaatt tgttttgtct gatataagaa tagctacctc tgctcacttt tggtgtctat 601 gtgcatgaaa tgcctttctc caccccttta ctttatgtga gtccttatgt gttgttaggc 661 cagcatcacc ctaatatcaa aaccagcaaa ggacatacca aaaaagaaca ttacagacca 721 atatttttga tgaacacaga tgctaaaatc ctcaacaaaa tactagctaa ccagttgcaa 781 caacatacca aaaagataat ccaccatgat caagtaagtt tcgtaccagg gatgcagaaa 841 agcagcagat ggtttgtgag ttcttatcta ttctgcaatt ctgtagaaaa gtggagcatt 901 taggccattt acattcaatg ttagtattga aatttgaggt accattgcat tcatcatgct 961 ctttgttgcc tgcgtacttt ggtttgtttt ttgattttgc tctttaactt gtatttttgt 1021 tttataggtc ctgtgtgatt tatgctttaa agagattctg ttttgatgtg tttccaggat 1081 ttctttcaag atttagagct cctttaaaca gttcttgtag cagtgccttg gtaatggcaa 1141 attctctcag tatttgtttg tctgaaaacg actgtatctt tccttcatat gtgatgctta 1201 gtttcactgg atgcaaaatt cttgactgat aattgttttg tttgaggagg ctgaagatag 1261 ggccccaacc ccttctagct tgtagggtct ctgctgagaa atctgctatt aatctgatag 1321 gttttcctta taggttacct ggtgcttctg tctcacagct cttaagattc tttccttggt 1381 cttaactttg tataacctga cgacaatgtg cctaggtgaa tatctttttg tatccatcgc 1941 ccaggctgga gtgcagtggc gcaattttgg ctcactgcaa cctctgcctc ccaggttcaa 1501 gcaattctcc tgcctcagcc tcccaaggag ctgggattac aggctcctgc caccacaccc 1561 agctaatttt ttttttttgt atttttagta gagacagggt tttgccatgt tggccagcct 1621 ggtctcaaac tcctgacctc aggtgatcca cctgcctcgg cctcccaaag tgctaggatt 1681 acaggcgtga gcccccgcac ccgagccctg atattaattt ttaaattaaa agactttatt 1741 tttaaaagca gtttgaggtt tacagaaaaa ctgagcagaa agtacagtct ctatataccc 1801 cctactccct gcccccagtt ttccctgtta ttaacatttg tgttaatgtg gcatatttgt 1861 tacaatcagt gaatcaatat tgataaatta aagtccatat gttagtgttc actctgtgtg 1921 ttatacagtt ctatgggttt tgccaaatgt attaatatgt catgtatcca tcattacagt WO 00/09525 PCfNS99/17712 1981 atcatccagc ataatttcac tgtcctgaaa atgccctgtg ctccacttat tcatcttttc 2091 cccacttgct atcaccacac caaagccctc acaaccactt atctttttaa tatatccata 2101 gttttgcctt ttgcagaaca tcatatcatt agaatcacaa taatatgtgg cttttcagac 2161 tggtttcttt cactcagcaa catgcagtta agggtcttcc gggtcttttg tggcttgaca ' 2221 gctcatttct ttttatcact gaataatatt gcattgtata gatataccac agtttttttt 2281 aaatttactc atcattaaag gacatcttga ttacttctaa tttctggcaa taatgaataa 2391 agttgataca aaaacttttg tgtaggattt tgtgtggaca tatgttttca actcattgag 2401 gtaaatgcct aaggcatatt tagttttgta agaaactgct aaactatctt ccaaagtatc 2961 tgtaccattt tgcattccca ccagctatga aagagtttct gttctacatc ttcacaaaca 2521 ttggtgttat cagtgttttg gattttagcc attctaattg gtgtggagtg gtatctcatt 2581 gttgttttaa ttttgcaatt ccctaatgac atatatgttg agcatctttt catatgcata 2641 tttaccatct gtatatcttc tttgggcata tgtccattca gatcttttgc acatcttttc 2701 attgggttgc tcattttctt attgagtttt aagagttctt catatatttt tgataacagt 2761 cctttatcag atatgtcttc tgcaaatatt ttctcccagt ctttgtcgtg tcttttcatt 2821 tacttaacag tgtctttcat aaaacagaag gttttaactt tgatgaagtc taacttgcca 2881 attttttctt tcatggattg tgctttgtgt gttgtatcta aaaactcatt gccaaacaca 2991 aggtcacctc tatgttctcc tatgttatct tctagaagct ttgtagtttt ctgttttaca 3001 tttatagggg ctgtgagaag gtgacagagg ttacatgagg taataaggat agggccttag 3061 ttgaataagg ctagtgccct tataagagga agagacgcca gttttctctc tctctaccat 3121 acgaagacac agcaagaaag tggccatcta caagtcaaga agtgggccat caccagaaac 3181 caaattactg gcaccttgat cttaaacttc ccagcttcca aaactgtgag aaataaattt 3291 ctgctgttta agccatgcaa cctacagtat aagttatagc agcccaagca gactaagaca 3301 gaacccttag catattaatc atagttactt taaatctctg gtcccataat tccaaaatat 3361 ctgccacatc tgagtctggt tctagtgctt gctttgtttc ttcaagactg tggttttttt 3921 tctcttttta gcatatctta taatttttct gttcaaagca aggcatgatg tactgggtaa 3981 agggaactga actgaggtag ataggtgttt agaatgaaat ttagaggcaa cttaagaaag 3541 tactcaaaaa acaaaattat gggagcatgc taaatggaca caggagccag cctgaaagag 3601 cttgcaatgg acaaagttgg aacaatttga gcaacaaaat aagttattct tccttataga 3661 ggaattctaa ataatttata tagatacttg ccttccagga agtggcactt aatccccatc 3721 aaaccctcat aagtgtgggc tggacttggt aacttccttc caaaaaatag agtatggaaa 3781 aggggtgaag taacttcata gtggaaaaac ctggcaaaca ctaccttggt tagctgagca 3891 aagccttgat atggtgtgat gagaatggaa tattaccttt gtgatctttc tctcaaacac 3901 ttataatccc attctaatca tgaggaaagc gtaagacaaa tcccaattga gggacattct 3961 acaaaatacc tgaggagtac tcctcaatag gtcatcaaaa caagtcttag aaactgtcac 4021 agtcaagaag aaactaagga aaaatgacaa ctaaatgcaa tgtggtatca tggactggct 9081 cctagaacag aaaaagtcag tatataaaaa ctaagaaaat ctgaataaag tatggacttt 9191 agtgataata atgtatcaat attggtttat tacttgtagc aaatgtacca tactaatcta 9201 agatgataat aaaaacaata actctgtgta gggccaaagg gagggaagtg ggctgatacg 4261 ggaactctcc gcactatctt agcaactttt tggcaaatct aaaattactc caagatacta 4321 agcttctttt ttaaaaaaaa tcacaaaacc tgaaaaattt taaagaaata aaaatttaaa 9381 aattaaaaag agtcaaatcc cagctgtatt tttattaatt atgtaatatt gtacaagtca 4441 ctctctgagc tttggtgtcc ctgtttataa aagtgataga atacattttt gagtgacatc 4501 tgaaagatag cagagtagga agctccaggc cctcctttcc ccatgtaatc tgtgaaagga 9561 aattcaattt cgggacgcca aactcattta gcgaaaggga aaagtcaaag tgggaactgg 9621 gtcatgcaaa cctgcctccc acttttgggt cctcaataag atggctacaa gatgaaaagc 4681 tacatgcctc cgccatattt tgcccacaag gaaattccta gtgagttgtt aaaatttcac 9741 cgtagcaatg caaattgata gcttatcttt acaggtgcag tcgcccccgg cgcactagac 9801 ataaatgcac atctgagtgt tcccctgccc cattttgtcc atgttatctt atgtaaaatg 9861 catattcccc acatttttcc tctgcctctt ttatgtcatc ttattaatgc agattccctg 9921 agccagacaa aggcatgaat gactattttt ccctaccctc ctcttacatg aaaattgtgt 4981 acttctcagt atcgcaccct ttccccttta aattttgagc cctcaaaatc atcttcggag 5041 acaggcatag acctgtctcc tgagtgcatc cttaactttg gcaaataaat cccctaaaat 5101 gattgagact tgtcattttt ctcaattgac atctggtaac cacgaaggga tcctgagtga 5161 aagtgaccca gcctgcagta gctcacctct cagtgcttgg caccggcttg gtcaccttat 5221 agcccaaact gagaggacaa tttgccaaag tcgaggacct ctttccaggg atctctgatc 5281 ttccaacatt ttccagttgg gggtctgaag tttatttgct gttaaaaaca aaacaaaaca 5341 acaaaaacaa caaaaattcc tttttttgta ggcgtttcca ctcacttcca tcaaggaagg 5401 cgagcctgtc tgcttctgca tatgcagaga gcaatcttca gcttgggccc ccatcactag 5461 gtaagaaact ggtttggaat tctgtcttgc aaattctttt aaacgactag aattagcact 5521 aacaaccagc tggtgttaat ttcctgctta cccttagagc gctcagaaat catataattt 5581 gcgtgatcat tgttagtttt gtttaattgt tttgtttctg ggtttgtgtg tgtgtgtgtg 5641 tgtgtgtata tatatctgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtg 5701 tgtgtgtgtg ttttggtcct ttcccctatc ggatttgacc aattctgaac cttcaagctc 5761 atgagtgtga aattttccac tctgaagaaa cagaacacat tgctcccctc agccctttgg 5821 ggcattctca ggcgactgag aatcacatga gggtttctgg gagaaatgct ccctaagaca 5881 tgcagcagct ctaaataggt ttccccctca aaagaacata cttagggtct aatctcagcc 5991 agcagatgca tataaggaac tgacccctcc caaactttga gcccctgaca cactgtgcca 6061 ggtggccaca acgctggtgg accaaactgg ttcagggtgt aatggccctg tgaaaagcta ggtttgcaag cagcacattt tgggtccaac acacatccca acttggtcaa atccaaaggg 6121 gaactctaaa ttatagagaa caaggcctct aagaccccag cagttgcaga atataaagtt 6181 cccctcttag aaactccagc agggtatatg caaaatactt atggtgaatc atcatgcaaa 6291 tatttaacca agcggaccac tataactaaa gcagattcta agttacaatg gcctaaatgg 6301 ggatcttttg agatgcccaa attagtgtac ctgtgaacca ggatggagaa tgcagacaca 6361 aaaaccaaac aaccagaatg ggacagctat tttcagtggt agctgcaaag tagcaaaagt 6421 ggggaagacc actgtcacgc gtgtctgggt gaagtgacca ccaaacaggc tttgtgtgtg 6481 caacaaggct gtttatttca cctgggtgca ggtgggctga gtccgaaaaa gatgtcagca 6591 aagggagtta ggggtggggc agttttatag gatttgagta ggtagtgtca ggaggcccga 6601 cactcctgtc ttcttatatt aataagaaaa acaaaacaag atagtggcga agtgttgggg 6661 tggcaaaaat tttggggggt ggtatagaga gataatgggc aatgtttctc agggctgctt 6721 cgagcaggat taggggcagc gtgggaacct agagtgggag agattaagct gaaggaagat 6781 tttgtggtaa ggggtgatat tgtggggttg ttagaagcaa tatttgttgt acagaatgat 6841 tggtgatggc ctggatacag ttttgtatga attgagaaac taaacagaag acacaaggtc 6901 cgaataagag aaggagaaaa acaggtatta aaggactaag aattgggagg acccaggaca 6961 tctaattaga gtgcctaagg gggttcagcg tgattattgc ttggttggtc agttttgggg 7021 ctctatcctt gagttttttt atgttgtcac ataccaggcc agattgattt aggtgaaaac 7081 aacactcttc atttaaaaat atagagtccc ctttttttaa gcagtgagta agcggaagtc 7141 tcggtgattt tggaggaaat agaaatgcaa agccagcaat tgtttgttaa agaaggatta 7201 gaaacggcta ggagagagtg agattgatag tgtggtggag atagctgggg agaggtagag 7261 ggtggcataa gaatgggaac gagaataaga gtgagtaaaa aagtaaagaa taggacttca 7321 tcagggtgaa agtaccggac tgtgccttgc cactgaagat cttttatcca cttcaagaga 7381 gatttaaggg tggtggtttg agataaaacc aggagatacc agttatgatg gtttggagga 7441 aaagtgtaaa ctgggagtgt aaacaagggc agggcattta tgagtagttg agaatggtga 7501 ataggagtat gactagacag aagatagtag ggatgacaag tttttggggt gcagtccaag 7561 ttgggctggt gtctggaatg agactggggc ctaataaaaa ggagtgtcca tacaggagct 7621 caaatgggct gtaccctgta gcatcccgag gacaggccca aattctgaga agggcaagtg 7681 gtaaaagtat tgtccagtcc tttttaagtt ggaggctgag cttggtgagg tgtgttttta 7741 aaagaccatt agtccatttt acctttcctg aagattgagg atgggaaggg gtatgaaggt 7801 tccactgaat accaggagcc tgagaaactg cttgggtgat ttgactaata aaggccggtc 7861 cgttatcaga ctgtatagag gtgggaaggc caaaccgagg aattgtgtct gacagaaggg 7921 aagaaatgac cacagtggac ttctcagacc ctgtgggaaa tgtctctacc catccagtga 7981 aagtgtctac ccagaccaag aggtatttta gtttcctgac tcagggcatg tgagtaaagt 8041 caatttgcca gtcctgggca ggggcaaatc cctgagcttg atgtgtaggg aagggagggg 8101 gcctgaacaa tccctgagaa gtagtagaat agcagatgga acactgagaa gtgatttcct 8161 tgaggataga gttccacgat agaaaggaaa tgagaggttc taagaggcgg gctagcagct 8221 tgtaacctac atggaagaag ttatgaaatg atgacagaat agaatgggcc tgtaaggctg 8281 gaagcaaata ttttccttgg tccaagaacc atttgccttg tgtgggaaga gattgatagg 8341 tggaagtttc agcgggggag taggtgggag tgaccaatga aaaggagaaa aactggcagt 8401 gagggacaga agttggaatg ctagctgctt ttttagttat cttattagca taagtgttgc 8961 cttgagcgat gggatctgat gccttttgat ggcccttgca gtgaatgact agcttttttg 8521 gaagtagagc agctttaaga agagttttta ttaaggaggc attaattatg gaggaccttt 8581 gtgtagtggg gaaacttttt tctgctcata taacagcatg gtagtgcagg atatggaagg 8641 catatttaaa gtcagtataa atattaacac atagtccctt tgcaagagtg agggcctgag 8701 ttaaggcaat gagtttggct tgctgagagg tagtggaggg gggcagagca gtagcctcaa 8761 ggatagatgt ggaagacact atagcttagc ctgcctttgc cagtgattgg cgattaggcc 8821 tggtggaact gccatcaagt gtgatcaggg tgaagaacag gaaagaagga aatatgggga 8881 aatggagtga atgccaggtg gatcagagag atacagtcat gggggtcaga tgtggtatca 8941 ggaataatgt gggaggccgg attgaagtcc aggccaggaa caacggtaac tgtgggagac 9001 tcaagaaaga gtaagtacag ctgaaggagc cagggggcag gaagtgtgag gaggaaaata 9061 gattttgaaa gttatgggaa ctgtagaggg ttagtggagc atagcttgtg atttttaggg 9121 cctctaaaag tattaaagcg gcagcaatga ggtgtggctg tagcctagga atagtcaggg 9181 aagcggataa tttagttaaa atgtctcaat ctaataaggg agctgggcag gtggggataa 9241 ctaaaaaaga gtgcataaaa gaatgttgtc caagttggca ccagagttgg ggagttttaa 9301 ggggtttaga agccttgctg tcaataccca caacagttat ggaggcaagg gaaacagtcc 9361 cttaaaaaga aggtaatgtg gagtgggtag cctccatatt gattaagaag gggacggact 9421 taccctccac tgtaagagtt acccaaagtg tctgtgatgg tccaggaggt ttccgaggcg 9481 attaggcaat gtcagtcttc aactgctaag ccacgaatat ctgggaagga gtcagtcaga 9541 gagccttggg ccagagttcc aggggatctg ggagtggctg ccaggcgagt tggacagtcc 9601 aatttccagt ggggtcccgc acagatggga catggcttag gaggaatccc gggctgcggg 9661 cattccttgg cccagtggcc agatttccgg cacttgaagc aagatcctgg gggtggcagt 9721 cctggaggaa cgcctggctg ctgcagttca ggtgttttga agttcttgtg tgctggagat 9781 gtggctgggg tttctctcac agtggaggca agtaattgca actcagaaat acgttgctac 9841 ttggctgcct ctactccatt attgtccaca ttgaaggaga ggttaattaa gtcctgttgt 9901 ggggtttgag ggccggaatc taatttttgg agctttttct aatgtcagga gcaggttggg 9961 taataaaatg catattgaga ataagatggc tttctggccc ttctgggtct agggcagtaa 10021 agcatctaag ggttgttgcc aaacgggaca tgaactaggc tggattttta tatttgatga 10081 aaaagagcct aaccactaac tgatttggga gaggtcagat aaagaaaaag gagaattaac 10141 cttggctatg ccttcagctc cagccacctc tttaagagga aattgttggg caggtcgggg 10201 agggctagtc acagaacaaa actataagct ggaccaggtg tgaggagggg aggtgataaa 10261 aggattatag ggtgggagag cagaggctga ggaagaattg ggacctggct cggcgtggca 10321.aggagcagcc tggggaggag gggagaggtc agataggtcc gtagaaaagg aggattcaaa 10381 ggactcagag cttgggatgg agactgaagg aacaggagag aaagaagaaa gatttgggac 10441 aagtcgcact gggagcagag actaaggagg gatcaatgtg taaaagaatg cctggacgtc 10501 aggcacctca gacccatttg cccatttttt gaccaaaatc atccaggtct tgtaaaatgg 10561 agaaatcaaa agtgccgttt tctggctatt tagaaccatt attgagtttg tattggggcc 10621 aagcagtgtt gcagaagaaa ataagacgct taggttttag gtcaggcgag agttgaagag 10681 gttttaagtt tttgagaaca caggctaagg gataagaaga gggaatggag ggtggaaggt 10741 tgcccatagt gaagaaggca agccccgaga aaatagaggg tagagacatg gagaaggggg 10801 gtggtgagca gccctgggct gcaatgtggg cgagcagcca cagccaaagc aggcgtccct 10861 gcaattgact tgccaccaag ggaatgtggg tgaatgacca aggtaggcat ccctgcggtg 10921 atcagacacc aatggagtgt gggtgaataa tcaggcaggt gtccccgcag tgattaaaca 10981 ccaagggaag actgtct~cc tgagttcatg actggcgccg gagttctggg tccatggata 11041 aaatgtgtct cctttgtctc tactagagag gaaaaagaac tagaattgga aggacagaga 11101 gattgaaggg tagcgagaga gggagactga agggtggcaa gagaggctgg agaagagagt 11161 aaaaagacca cttacccgat ttgaaattgg tgagatgttc cttgggctgg ttggtctgag 11221 gacccgaggt cataggtgga tctcctcatg gagtgagggc gaggacaggg gactggtctc 11281 ccaaaggagt cctcctgtcc cgggtcttcg gcaccaaatg tcacactcgt ccgtgtgaag 11341 agaccaccaa acaggctttg tgtgagcaac aaggctgttt atttcacctg ggcgcagttg 11901 ggctgagtcc gaaaaaggag tcagcaaagg gagttagggg tggggcagtt ttataggatt 11461 taggtaggta gtggaaaatt acagtcaaag ggggttgttc tcttgcgggc aggggctggg 11521 gtcacaaggt gctcggtggg ggagcttctg agctaggaca tttcacaagg taatgtaatc 11581 agttaaggca ggaacaggcc attttcactt cttttgtgat tcttcagttg cttcaggcca 11691 tctggatata tacgtgcagg cttgggctca gaggcctgac aaccacctca tctccctaca 11701 ggaggccaac aaacaactta gaaatgctaa ccaagaactc tgtaatcttg tatctctctt 11761 aaagaaatcc tcagaattcc ttacttcccc cttggtacct ccccctacac ccctactcta 11821 ccctgaccaa tctgaacttc ctggaccaga tctgtccgcc gcctctactg catgtctaac 11881 acttgctcaa cagaaggcag ttcagagtct gactgcaaag accccacccc ctcatgattc 11941 cctgacagct ccaatggcaa catctcatct ggaagatgtg gaaaaggggg accgtgcagg 12001 gatatctctc atgatcaccc tattttggga acaactgcta acaggtaggg gaaccctggt 12061 aattgtctac caacaccctg gtcaaaggct gaattccaag gcataaagaa tttcctgacc 12121 cccataaaga tccaattggg tttgagtatt tgagctcatt gtcagaacct atgacccagg 12181 tcattcagac ttttatcagc tagtccacat gttggtctca gaagctaaag ctaaggaatg 12241 gctgggaaaa gcacaatggt cagactctat agcagatttg acccctgaag gcccaatgga 12301 gccacaacaa ccagccccca caaatccaga agacaggcac aaagatgtgc aggaatgagc 12361 aaccactcta ttaaatatca ttccttcagt gttccaaagg gttgtggatt ggaataaaat 12421 ccaacaatgt caccagaacc caaataaatt agttttagat tatttaacac attttgataa 12981 aactttaaaa caacattgtg ggatgtcagc tgattgcttt gaaaacaata aaaatgatac 12591 attattaaat gcaaatttct taaacggact agatgatgat ttagccaccc ttgtaaaaca 12601 caaattggac cacagccaga actaatgaac tagttaactt agctgaccaa ttatcccgca 12661 ctatgataaa acaaggaaaa acagaagatt gcccaagtta tgcatttaca gctaaagcaa 12721 ttaacttctc aagcctctcg gccccagaaa gattttaagc tccctcggtc tgaggactct 12781 tccctcccag tctgttacaa ctgtaaatga ccgagacacc ttatgatgga ttgccttagg 12841 ctgaaacaaa agaaaaggca gaatgcaact caggaagaca aggggtgctc caaggaaata 12901 caggggtttc acctctccaa atattctacc ctgacaaacc aattggggga gattaatata 12961 ataataaacc atgagtttac aactgcctta actgacatag gtgtgactat ctctgaaaaa 13021 tcccacctta tttagaaacc ccattcctca gagtaatgaa agaatgaaca tggtgggtat 13081 gtctaataaa atgatctcat gttttaagtc caaacccgta ccttagggtt catcaggttc 13141 cactaccctg tcgcaggctc taagtgtgac acactcagta ggtcccatat gtttctaata 13201 tgcactgggg cccctgtcaa acttttgggc tgtgatctca acatccataa tgcccatatc 13261 tctttttcat caaaaggtga aactttttta gaattggagc caggagacca aaaataccat 13321 atttaaaaat gtcctgacaa cgtacaattt agtactagta atgttaaaat gtcatcttgt 13381 gaccaggaaa ataaaataga gacagagaag gaaatattag ggaagaagag agaacattgg 13941 aatacagagc aggaaacagt aaaactcctt ttagtttccc cagtcttcct gttaacacca 13501 gaagcagagc acttgctcaa ggatgtgtcc tcccacttat agtctcagtc aaatacagat 13561 acagagaaag tattctcagc cattccaata aaggtagaga taaatccaaa gaaaccccta 13621 tccaacctta aacactatcc tctgcaaaag gaagccatag atggaattgc tcctgtcata 13681 caagattatc tgagaaacgg gctcattatt ccctgcacaa tcccctgaaa cagccctata 13791 ttccctgtaa agaaactaag cgggagagga tggaaatttg tgcaggaatt gagggcaata 13801 aacaatatca taattctcag gcacacagta gtccccaacc cacaaaccct tctatcacct 13861 atatccacta ccagccagta tttctcagtt gtggatctct gcagtgcctt ctttagtatt 13921 cctgtagaac cagacagcca atatttgttt gtctttattt ggaaagaatg gcaatatacg 13981 tggactataa tgccccaaag gtatacagaa agtcccactt agtgttccca aatattagaa 14041 gctgatttgg agaattaaat attttcccag ggctcaacat tcatctactc tcctttgttc 19101 agacacactc tcttcctctc aggaagatag tctatattta ctcaaacagc caccaaggga 14161 cacaaatgtc taaagacaaa cttcagctat gcttacctga agttaagtat ttgggacata 19221 ttatctcagc caaaggactg agtattaacc ctgatagagt gaggaatttt agctttccca 14281 atgcccgtca ctaagaaaca acttagagta ttttggggcc tggcaggcta ttgtagaaac 14341 tggataccaa atttctccct tatggctcaa cttcagtgta catacctaaa aaatgaacaa 14401 cctgatccca tcatgtggac tccggaggga caatcagctg tacaacaaat aaaggaaatt 19961 ctgactaatg ccccagcctt agggcacccg aactacaaat tgcctttctc ccttttcata 14521 cacgaagttg gaggtactgc atccggagta ctgacccaga aacatggtga tcatcagaga 19581 cctataggct attatagcca acagctggac cctgtggctc aagggctgcc tccctatgtg 14691 agagcaatag cagccacggc ccttccgtat aagtctgttg aagaaataat tataggttcc 14701 ccccttaaca tttttgtgcc acattctctt gagacccttc taaactctca tcatacacaa 14761 cacctgtctg tcaactggtt agcctcttat gaaattttgc ttttatcatc tcccaatatt 19821 actagttcct gctgtaataa tcttaatctg gccactctct tgccaggccc ttctgacaaa 19881 accccctcat gactgtgttt tgatgactga cttctcaccc ccaggacaga cctacaagag 14941 atgccactgg ataatgctga gatagaatgg tatacagatg gatcttattt aagaggagag 15001 gatggaaatt ttatagcagg atatgctgtg gtttccttac tagaggtaat tgaagccaat 15061 cctctccccc aagccagatc agctcaagtg accaaattgg ttgccctgac cgaagcttgt 15121 caattggcaa aagacaaggc tgcaaacatt tacactgaca gccactatgc ttttggggtt 15181 gctcatgact gggatgttat ggaaagagag aggatattta accccctcag ggcaacccat 15241 aaaaaatgga caagtatcag agttgttaga agctgttcta acaccaaaac gcttggcaat 15301 tataaaaatc ccaggttggc caggcgcagt ggctcacgcc tgtaatccca gcactttggg 15361 aggccgaggc aggaggatca cgaggtcagg agatcgagac catcctggct aacatggcga 15921 aaccccgtct ctactaaaaa tacaaacccc gtctctacta aaaatacaaa aagttagccg EPl-109 907 15981 ggcgtggtgg tgggcgcttg tagtcccagc tactcgggag gctgagg~ag gagaatggca 15541 tgaacctggg aggcagagct tgcagtgagc cgagatggcg ccactgcact ccagcctggg 15601 caacagagag agactccgtc tcaaaaataa ataaataaaa ttaaaaaaaa atcccaggtc 15661 actcaaaatt agacaccaca gtaagtcagg gtaaccaatt tgctgaagcc acagctaaaa 15721 gagcagcatt caagccatca gccccaagtt ggaaaatggc cataaaaccc aaaacactta 15781 aatacatgtt gaaagaaacc cagagcatag ctcctacaaa agagaaatct acttggaaac 15891 aggcaggggg atacttgtct cccaaaactg aaatatggtg tggacctaat tattccattc 15901 caagaaaccc attattccaa tggaatgtca ggtgtccctt atgaaatatg ttcataatct 15961 aacccattgg aatccagata aaataatatc ctggtgtaaa caatattact ggaaaccatc 16021 cttcacagtg gcacaaaaag tttactctca gccgggcacc atggctcaca cctgtaatcc 16081 cagcactttg ggaggcccag gcaggtagat cacctgaggt caggagttca agaccagcct 16191 ggctaacatg gcaaaaccct gtatctacta aaaatacaaa aattagccag gcatggtggt 16201 gcgtgcctgt aatcctgctt cttgggaggc tgaggcagaa gaatcgcctg aacccaggag 16261 gcagaggttg cagtgagctg agatcacgcc attgcactct agcctgggcg acaagagcga 16321 aactccatct caaaaaacca aacaaaaaag tttactctca atgtgttatc tgtcccaaac 16381 ataacccagg aaaacccctc catggggccc agggtcattt tccccttccg gctgaccttt 16441 tgaggtatga cagcttgatt ttatccagct gccatcatct caatgttaca agtatgtttt 16501 agtaatggtc tgcatgtttt atcattgggt tgaagctttt ccctgcaggc aagcaacagc 16561 cacgacagtt ggaaaaatcc tactagaaaa aattgtccca ctgtggggag tcccctgtga 16621 acttcacagt gatgggggat catactttac tggccaggtt actcaaaata tttgtaaaat 16681 ttggcccata tttcaacatt tccattgtgc caccatcccc agtcttcagg cctggtggag 16791 aggaccaatg gaataattaa aacacaattg gctaagttca cagaggcatt tcacctcccc 16801 tggcccaaag cactacccct agtgctgctt atactacgat ccactccttt tggaaaacat 16861 caactgtctc cttatgaaat tataacagga aggcccatgt gtatgggaac gaacataacc 16921 aatccaactt ttctccaggg agatatattg caatattgtg agggactcat ttatcatctt 16981 agaaaaaacc aaaatttgtt aaaaaattcc tttcacggtg cgctccccga agataaggtg 17041 cctggtcatc tgcaacctgg agatttcatc tattggaaaa gacatctaat aaaggattcc 17101 cttcaaccct gatggaaggg cccgtaccag gcactactga ctaatccatg tactgcaaaa 17161 ttaaagagta tagattcatg gattcacatc tctcatctta aaaaggcaca acctcctgag 17221 tggactgtaa ctcccaccaa agaccttcac ctccggttca ctaaacatca acctgcaacc 17281 caggattaga agcagacaac agctgttgtg gactgcttaa acccaagaca cagaaccagg 17341 cctgtataca aagggaacgc ctctgtttat tgtacagtaa ccattacaat tattgtccta 17901 gatataccgg caactgctgt cttataaatg acagggcact tgccttgtct gatttaacac 17461 catttagtaa ctaaaatgaa tttcgcaacc ttgctattat taatcctata tccctacact 17521 ttcttgccac tgccacccac tgatgcccat gaaacaaacc tgtttctaca atgggctcag 17581 cattatgcag acaaattaca aagaacacct gctggatatg cagactcatg cctctttcca 17641 gtggctccag cctgccatgg tggatatccc ccttccaagg tcaggactgg atagaatacc 17701 aaaaatttat cacatcacag aaatggtctg gtattcttag tgctgggata acaaaagaca 17761 atacatacaa ttqgcccatt aaaaacactc ttaagaacaa gggacatggg aaaagatttt 17821 gaatggaaag gaccaggtca ttagctctca ctttagcatc cccccagcta aaacagaagg 17881 tggtaaccac accccaaaca acagctcatt ttcaaaatgg aataatgcaa atttgggctg 17941 gatttatctg gctcacccgt tcgtctggcc aactcagcca aaattctcct ctgtgctggg 18001 agaaagaaac catatcaagg acctatggcc aaacagtacg agagatacgg ggtggacacc 18061 tggagaatgc tgtgaccaca ttatcatatt acaagacgct gactggaatg ccaccgattg 18121 ggtgcagcaa tcaggtattt attggatagc tccaaatggg acatattggc tatgtggcac 18181 taacttatgg ccgtggttac ctctagggta gttaggatga tgttccctag gttatgcttg 18291 ggcacaagac acgtaatcca gaccctgcca aaaccagcaa acctttttca tttacaattt 18301 cattggacat gttaggtatt ccaatggtat gatcacttag ctttaatctt tgtaccacag 18361 acaggtattg aagatgttat atggcatata gaggccttac ccaattacat ccaaaaggcc 18421 ctgaatgata gccacatgag tattgccttg ctaagcaatg aggtcatgct tatgaggaaa 18481 gttgtgctat acaaccatat ggctttagat atactcattg cagcacaagg ggggacctgt 18591 gccgtcataa aaactgaatg ttgtgtgtat attcagatga attgaagaac ataactcgat 18601 ttatgactga tatgaaaacc cagataacca acctgtcaga tctaaaaccc tcactaatca 18661 attggttgag tagttggttt ggatcctggg gaacttggtg gcagaagcta ctgcttataa 18721 taggaataat aataatttgt gttctgtcct gtttctgcta caatgttgtt acggtatgtg 18781 cttgcaaata agttaatgca caactgaaag ggctggggta ataattgccc agagaattgc 18841 tttaattgag gaagcagtaa tatagcttga cccagcttca aggtttgctt tccttttgtt 18901 gctataaata tgacctaggt ccctatatat atattttttt ctttttcttt tttcctttcc 18961 tttttccttt tttcctctcc cttttttttt taaatattcg tgggacacaa tttcctagga 19021 atgagccttc ctagcgacaa tgggcgtgac ttcctaggaa tgagccttcc tggtgatgtg 19081 ggacctaaac ttctagaaat aaactatcct agcaacagga aaccagttca gaaaagggag 19141 gaaaaatcaa cctgtagcca agaacccata ttccttttaa aatgcttcct tcaaaagatt 19201 ttaaataaaa aaagagggga aacctgaaag gaaattaaat tttgggaccc cccaaactca 19261 tttagcaaaa ggcaaaagtc aaaatgggaa ctgggtcatc caaacctgcc tccccctttt 19321,ggttcctcaa taaaattgtt acaagatgaa aagctacatg tctcctccat attttgccca 19381 cagagaaatt tctagtgagt tgttaaaatt tcaccatggc aatgcaaatc gatagcttat 19941 ctttacaggt gcagtcgccc ctqgcccacc agacataaat gcatatctga gtgttcccct 19501 gcccaatttt gtctatgtta tcttatgtaa aatgcagatt ccccagattt ttcctctgcc 19561 ccttttatgt catcttttat ttatttattt atttatttat ttatttactt atttattttg 19621 agatggagtt tcgctcttgt tgcccaggct ggagtgcaat ggcacgatct cggctcacag 19681 caacctccgc ctcctgggtt caagcaattc tcctgcctca gcctccagag tagctgggat 19741 tacaggcatg caccaccaat cccagctaat ttttgtattt ttagtagaga tggggtttct 19801 ccatgttggt caggctggtc tcgaactcca gacctcaggt gatccacccg cctcggcctc 19861 ccaaagtgct gggattacag gcgtgagcca ccacgcctgg cctttttgtt gttatttagt 19921 tttatttcat atcataaact taactctgca atccagctag acatggaaag gaacaaggaa EPI-109 ~8 19981 aacatggaac ccaaagggaa ctgcaatgag agcacaaaga ttataggcta ttgccagcaa 20091 atggggtgga ggggtgctct cctgagctac agaaggaatg gtctggtggt taagataaaa 20101 cacaagtcaa actttaataa gttgtccata gtcagcaatg gtgatcttct tgctggtctt 20161 gccattcctg gacccaaagc attccatggc ccccacaata tttatgcctt cttttacctt~
20221 gccaaagacc acatgtttgt catccactca gtcttggcag tgcagatgaa aaactgggaa 20341 ctgtttgtgt ccagcatttg ccatggacaa gatgccagga cctgtatgct ttaggatgaa gttcttgtca tcaaatttct ccctgtagat ggacttgcca ccagtgccat tatggcaatg 20401 tgaagtcacc accctgacac ataaaccctg gaataagtct gtgaacgcag gaacccttat 20961 aaccaaatcc tttctctcca gtgtgcacag catgaaattt ttctggtgtc ttggaaactt 20521 gtctgcaaac agcttgaagg agatgtggcc caagagccca ccatctatgg tgatgttgaa 20581 gaacaaggtg gggttgacca tggctgatag tacggggctc ctggcagcag cagcatctgt 20641 gaagtggcca ttctatgtta tcttatattt aaaaaatgca gatttgctga accagacaaa 20701 ggcatgaatg actatttttc cctaccccct cttacatgaa aattgtttac ttctcaatat 20761 cctacccttt cccctttaaa tttgaagccc tcaaaatcac cttcggagaa aggcatagac 20821 ctgtctcctg ggcacgtcct taactttggc aaataaatct aaaatcattg ggacttattt 20881 catcattttt ctcaattgac aaaacattta aaaaataata cagactggac ccagcctgcc 20941 caactcccag tggagagcaa ggtttccttc tattttcata ggcaaccaga acaatgttct 21001 atgcacattt tgtcctcagt aagagggcct ctggccaaaa tttggctagc ggcccattgg 21061 gataagaagc taaccaaagc ccctgtgtta cagtgtaatt tagagagcag catggagagt 21121 atcatctcac caaaggtgaa gatagcatta cggacatcag gacatctctt actgggagta 21181 gtttgaatct atcacaggaa agccaaatat cttcttgcag actgtaatga agcattcatt 21241 aagataaaga tggctttttg atcaggtgtt gacctgcctg aggaaaatca ggaagcagct 21301 tataacacca ttactttact tgaataattt catgactttg atcagccact gcctgactta 21361 gatgacatcg atgtggccca gaagttcagc ctgggtcaga gtagagtgga agaaataacc 21921 gtgagagaag aagttgggaa tatcagtatt ttacaagaaa atggttttgg cgattttgga 21981 atggatgatc attgagatca gagaaagcag tgcttttgag gatgatgaca tgttagtagg 21541 cactactgct tctaatctcc tattagagtc tgaacagagc accagcaatc tgaatgagaa 21601 aattaaccat ttagaatatg aagaccaata taaagataat aattttggag aaggaaatga 21661 tggtggaata ttagaagaca aacttattag taataatgat ggtagtatct ttgatgatcc 21721 ccctgccctc tctgaggcag aggtaatgtt gccagagcag cctgcacatg atgatatacg 21781 ggtgaggatg ataatacatc aatgggtggg cctgatagtc ctgattcagt gaatcctgtt 21841 gaaccagcca actatgactg atcaaacaac acttgttcca aatgaggaag aagcatttgc 21901 attggaacct attgatataa ctgttaaaga aacaaacgcc aagaggaaga ggaagctaat 21961 tgttgacagt gtcaaaaact tggatagcaa gacaattaga gcccagctta atgattattc 22021 tgatattgtt actactttgg atctggcacc acccaccaag aaataggtga tgtggaaaga 22081 gacaggagta gtagaaaaac tgttttcttt acctgctcag cctttgtgga ataacagact 22191 actgacgctc tttacatgct gtcttacacc acttgtacca gaagacctta gaaaaagggg 22201 gaaaggaggg acagataatt tggatgagtt cctcaaagaa cttgaaaatc cagaggttcc 22261 tagagagaac tagcaacagc tacaccagca gcatgatgtt attgataagc ccattttgga 22321 agagccaagc catctccaga agtcagtgat gaggccagca gaacaaatct ggatgagtca 22381 gctatgcctc caccaccacc tcagggagtt aagtgaaaag ctggacaaat taacccagag 22991 cctgtgatgc ctcctcagca ggttgagcag atggaaatac tgcctgtaga gcttccccaa 22501 gaagaacctc caaatatctg tcagctaata ccagagttag aacttctgcc agaaaaagag 22561 aatgagaaag aaaaggggaa aaaaagatga tgaaggggaa aaggatgaag atgtttcagg 22621 gggtgatcaa gatcaggaag aaagaagatg gaagaaaagg actcagcaga tgcttcacgg 22681 tcttcagtga gctcttgcta aaactggagc tgaatctatc agtttgcttg agttatatca 22741 aaacacaaac agaaaacaaa ctgttgcaaa gttctacagc ttcttggttc ttaaaaagca 22801 gcaagctatt gagctgacac aggaagaact gtacagtaac atcatcgcaa cacccgggcc 22861 aaagttccat attttatgag gagctagaag cattatagct agtgttcatt tcactagtgc 22921 ttacaaattg cccccatgtg taggagacac agaacccttt gagaaaactt agatttttgt 22981 ctgtacaaag tctttgcctt tttctttctc attttttccc agtatattaa atttgtcagt 23041 ttcatctttg agggaaactg attagatgga tgtgtttgtg ttctgatgga gaaaacagca 23101 ccctaaggac tcagaagatt aacagttcag aacagatgtg tgcaatattg gtgcatgcaa 23161 tgatgttgag tggcagttga aagtcatgat ttttatctta gttcttcatt actgcattga 23221 aaaggaaaac ctgtctggga aaatgcctga cagtttaatt taaaactatg gtatgagtct 23281 ttgaaaagaa aaaaaaaaag cctttccatc agtagtaaca ctggcaatct tcttgttaac 23341 cactctcctt agggatggta cctgaaataa caaaggtcac cctcttgaga ttcgttttaa 23401 gtgtaattcc ctaatgagca aacgtgtacg tgaaattgtg ttgtgactga tacccttcag 23461 ctacagatag gactgacttg gtttaaagtg ttctattttg taaatcattc catttgagtc 23521 tttctgatga acttcgctat ctcgaaatct gtcattttag tgaggctcca aaatgagcag 23581 aaataggcct gattagagta gagtgactat caaatagcag actttctagg acctataaat 23641 agaagtttta aaaagatgtt tggatatatt tgactattca gatcatgaaa acagaaatta 23701 ccctgcctac tacaaggaca gactgatggg aaattataca ccaggtcaac ttaaccttta 23761 agcagacaat gctgtaaaaa ctaatggctt ctctgatatt tattgtaagt tttagtactg 2382.1 atctcctttt ccagtgctgc acactcctgt gtttggaact ttaatagctt tgcaacgaaa 23881 tcctatatcc ggtttcctat aatttaactg aagaaaaaca catccaaata aaggtctata 23991 ttaacagacc agatagcatc agaaatcatg tgactattat gattatcaga atatgtctta 29001 actttttagg gcaaaattaa cactgaaagt tctagcttaa gtgttgacac tttcgtgggg 24061 aaaaaaatca cttttgaaac agacttcagt gtatactcaa taatttaaaa ttatgtgaaa 24121 tgttttaaat ttgtgaactc attactgttt taatgattcc gtttcttgag agtttaacca 24181 taaaaaattg ctattgcaga tttattttca atatgctgtg cctgtaaacc atggagtttt 24241 ccctgtttgt aaaaagacat tgtagataat tgaatgtttg attttagaaa ggtcattggt 29301 ttcttgttac acattttgtt agtctgtttt ttttgcttat tgggtttaat attgttcttg 24361 aaaatagttg atgctatgtt atgtataact cttctaataa aagttgtgtt ataagttgaa 24421 acaaattata gtattacaga ctggctacaa taactttata ggaagtctga aaaatactca 29981 aagttctata gcaaccaagc aaacacctag tcaagaaaac gatacagtca aaatggttag 29541 aaattttgtg acatttttac ttgcctgtac cccatccttc cctcctggca cacctgggga 29601 agcagcagcc ctgctcccaa ttccctccct ggaaccccag agagaggaaa gtggacttta 24661 tttgcaacat tctaacctgt caaggggctg cctgaggtac tggtctctgt tttacctaat 29721 tcggaggtca gacagggaaa agcaacatgg ctggatactc aggctcagga aaagccacag 29781 gaaatgatgg gcactactca tgaacactgc agggggccta caaactcaca gatacctgga 24891 gcaagagatc agaagtagaa gaatacaata gaacatctaa gcccaccttc tgagaagcag 24901 aggtgagact ctttaggaaa ttgagacatt ttaagcagtc atgcattcaa gggaactgga 24961 aaacaacaac aacaacaaca acaacagata cccaggccaa ggcaaaatgc atagccaaaa 25021 gaggtctaag aagaccttaa gacctcacat ggggctgatc ccaaagctga cagcatgccc 25081 tgctaattag tgaaggtctt ccctggcaca gaacctactt gtaatgacta gcagaggtgg 25191 ctgttttttt gaatgatcaa ttttaaaaat gaacaaaaaa ataacaaacc atgcaaagaa 25201 acaggaaaat atggcccatt caaaggaaga taataaactg tcagaaactg tccctgaaga 25261 aacacaagca tcagaagtac tagacaaaga caaaatgtct taaatatgct caaagagcta 25321 aatgaaaact caaagaacta aaggaaatga gaaaaatgac acataaacaa aagagaatat 25381 taacaaagag aaactataaa aaggaaccaa acagaaattc tggagctgaa aatacagtat 25491 ctgaattgaa aaacgcctag agggattcaa cagtagattc aaacaggaag aaaaaagaat 25501 cagtgaactt gaagataagt cctttgaaat tattgaatct gaagaccaaa taataataat 25561 aataattaag aaaagtggac agagactaag agacctatgg gataccatca agctaaccaa 25621 tatatgcatt acagaaatct cagatggtga cgggataaag aaaggagcag aggaactatt 25681 tgaaaaaata atggctgaaa acttcccaaa tttgaggaaa ggcattgatt cacaaatcca 25791 aaaatcttgc tgatctccag gtaggataaa cccaaagcag tacataccaa gacacattat 25801 attctaacaa aagccaaaga catggaacac tgcaggggga ctacagactc acagaaaccg 25861 ggggcaagag atcagaggta aaggaataca atacaaagtc taaggccccc tcaagaatct 25921 tgaaagaagc aagagaaaag taactcatca tgcacaatgg atcttcaata acattatcag 25981 tggatttctc agcaaaaacc ttgaaggaca caaggaattg aataccatat ttaaaggaaa 26091 ttttttaatt gttatttttc cataagttat tggagttcag gtggtatttg gttacgagta 26101 agttatttaa tggtgatttg tgagattttg gtgacctgtc accgaagcag tatacactgc 26161 actgtatttg tagtctttca tccctcaccc acctcccact cttccctcca agtccccaaa 26221 gtccattgta tcattcttat gcttttgtgt cctcatagct tagctcccgc atatcagtga 26281 gaacacgtga tgcttggttt tccattcctg agttacttca cttagaataa tagtctccaa 26341 tctcatccag gtcactgcaa atgctgctaa ttcattcctt tttatggctg cacagtattc 26901 catcatatat atataccaca gtttctttat ccacttgttg attgctgggc atttgggttg 26461 gttccatgat tttgcaattg tgaattgtgc cgctataaac atacatatgc aagttatctt 26521 ttttgaataa tgacttcttt tcctctgggt agacacccag tagtgggatt gctggatcaa 26581 atggtagttc acttttagtt ctttaaggaa tctccacact attttccata gtggctgtag 26641 tagtttactt tccaccagca gtgtggaagt gttccctgtt taccacatcc acaccaacgt 26701 ctactgtttt ttttattatg gccattcttg caggagtaag gaggtattgc attgtggttt 26761 tgatttgcat ttccctgatc attagtgatg ttgagcattt tttcgccatt tgtgtatctt 26821 ttgagaattg tctattcatc tccttagtcc actttttgat gggattgtgg gtttttcttt 26881 cttattgatt tgtttgagtt cgttgtagat tctggatatt agtcctttgt cagatgtata 26941 gattctgaag cttttctccc actctgtggg ttgtctgttt actctgctga ctgttccttt 27001 tctgtgcaaa agctctttag tttaattaga tcccagctat ttatcttttt attgcatttg 27061 cttttgggtt cttggtcatg aaatccttgc tgaagccaat gtctagaagg gtttttccaa 27121 tgttatcttc tagaattttt atagtttcag gtcttaggtt taagtcctta atccatcttg 27181 agttgatttt tgtataaggt gagagatgag gatccattgt cattctccta catgtggcta 27241 gccaattacc ccagcaccat ttgttgaaaa aggtgccctt ttcccacttt gtttttgttt 27301 gctttgttga agatcagttg gctctaagta tttgggttta tttctgggtt ctctattctg 27361 ttccattggt ctacgtgcct atttttatac cagtaccaca ttgttttggt gactatggcc 27421 ttatagtata gtttgaaatc agctagtgtg atgcctccac atttgtcctt tttgcttagt 27981 cttcctttgg ctatgcgggc tcttttttgg ttccatatga ttttgggaat tgttttttct 27591 aattctgtga agaatgatgg tggtattctg atagagattg cattgaattt gtagatggct 27601 tttggcagta tggtcatttt cacaatatta attctaccca tccatgagca tgggagatgt 27661 ttccatttgt ttgtgtcata tatgatttct tacagcagtg tttgtagttt tccttgtaaa 27721 ggtcttttaa ctcattggtt aggtatattc ttaagtgttt tttttttttt tttgcaacta 27781 ttgcaaaagg ggttgagttc ttgatttgat tctctgcttg gttgctgttg gtgtatagaa 27891 gagctactta tttgtgtaca ttaatcttgt atgcagaaat tttgctgaat tcttttatca 27901 gttctaggag ctttctggag gagtctttag gggtttcaag gtaaatgact gctatatata 27961 aagtttcagt ggcacaaaag aaatagcact caaatataaa attttctttt taattctcag 28021 caaggctagt tacttctcta tagaagggtg tgcccttaca gatggaacaa tggtgagcgc 28081 acacttggac gaggggaagg gattcttatc cctgacacac atggcccctg ctgctgttgt 28191 tcccctattg gctagggtca gaccgaacag actaaactaa ttccgaccag ctaatttaaa 28201 gagaatgacg gggtgagtgc tttggaggga gtcagggcag agcaggtagc aggtaaatgg 28261 aatgagttag ggtggagcag gtgattggaa tgtagggtgg agcaggtgat cagaatgagt 28321' cagggtggag taggtaaccg aaaaaggttg ctttacgagg aagttaagtt taaaagtaga 28381 aggcaaagaa ttgaacatac tgacatatta attcttcgaa aagaaattta gaactcatat 28941 ctaacatgat catatcatca gcaaacagtg acagtttgac ttcctcttta ccaattggat 28501 gccctttatt tctttctctt gtctgactgc tttggctagg acttccagta ctatgttgaa 28561 gaggagtggt gagagtgggc atgcttgtct tgttccagtt ctcagaggga atggtttcaa 28621 cttttcctca atcagtatta tgttggctgt gggtttgtca tagatggatt ttattacatt 28681 aaggtatgtc ccttgtatgc cgattttact cagagtttta atcatatagg aatgctgggt 28741 ttcgtcaaat gctttttctg catgtattgt gatgatcatg tgatttttgt ttttaattct 28801 gtttatgtgg tgtataacat ttattgactt gtgtaggtaa aaccatccct gcgtccctgg 28861 tacaaaactt acttgatcat ggtggattat ctttttgata tgttgttaga actggttagc 28921 tagtattttg ttgaggattt tagcatctgt gttcatcaaa aatattggtc tgtaattgtc EPI-109 910 _ 28981 ttttttggtt atgttctttg ctggttttgg tattaggatg atgctggctt catagaatga 29091 attagggagg gttccttctt tctctgtctt gtaaaatagt gtcaaaagga ttgataccaa 29101 ttctttgaat gtctgctaga agtctgctgt gaatccgtct ggtcctggac ttttttttgt 29161 tggtaatttt cttaattacc atttcaatct cactgcttgt tgttggtctg ttcagggtat~
29221 cttatccttc ctgatttaaa ctaggagggt tgtatttttc cacgaattta tccatctctt 29281 ctgggttttc tagtttatgt gcataaaggt attcatagca gccttgaatg atcttctgtt 29341 tctgtggtgt cagttgtaat atctcccatt tcatttcttt cctttttttt ttttttgaga 29401 tggagtctca ctctgtcccc caggctggag tgcagtggtg ccatctcagc tcactgcaac 29461 ctccactcct gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacgg 29521 gcacccacca ccacgcccag ctaatttttt ttctgttttt agtagagaca gggtttcact 29581 gtgttagcca ggatggtctc gatctcctga ccccatgatc cgcccacctc agcctcccaa 29641 agtgctggga ttacaggtgt gagccaccgc acccggccct ctcccgtctc atttcttact 29701 gagcttattt ggattttctc tcttctttac ttggttaatc ttgctaatgg tctatcaatt 29761 ttatttgtct ttcaaagaac cagcttttca tttcatttac cttctgtatt tttgttcatt 29821 tcaatttcac ttagttctgc tctgatcttg gtgatttcct ttcttctgct gggtttgggt 29881 ttggtttgtt cttgtttctc tagttccttg aggtgtgacc ttagattgtc tgtttgtgct 29991 ctttcagact ttttgatgta ggcgtttagg gctatgaact ttcctcttag cactgccttt 30001 gctgaatccc agaggttttg atagttgtgg cattattgtc attcagtttg aagagttttt 30061 aaatttccat cttgatttca tttttgaccc aatgctcatt ctggaccagg ttatttaact 30121 tccatgtatt tgcatggttt tgaaggttcc ctttgaagtt gatttccagt tttattccac 30181 tgtggtctga gagagtgttt gatataattt caattttctt aaatgtattg aagctcattt 30291 tatggcctat catatagtct atcttggaga aagttccatg tattgttgaa tagaatgttt 30301 tattctgcag ttgttggatg aaatgttctg tatatatctg ttaagtccaa ttgttccaac 30361 gtatagttta aatccattgt ttctttgttg actttctgcc ttgatgaact gtctatggct 30421 gtcagtggag taatgaagtc ctccatgatt attgtgttgc tatctatctc atttcttagg 30481 tgtattagta actgttttat taattttgga gttccagtgt taggtgccta tatgtttagg 30591 attgtgatat tttcctgttg gaaaggcctt ttaccattat atactgtccc tctttgtctt 30601 ttgtaactgc tattgcttca aagtttgttt tgtctaagaa tagctacccc tgctcgtttt 30661 tggtgtccat ttgcatgaaa tgcctttttc caccccttta ttttaagttt atgtgagtcc 30721 ttatgtgtta ggtgagtctc ctgaaggcag cagatagttg gttggtgagt tcttattcat 30781 tctgcagttc tgtatctttt aagcggagca tttagaccat ttatattcaa tgttaatatt 30891 gaaatgtgag gtactgttgc tttcatcatg ctctttgttg cttgtgtact ttggtttttg 30901 ttgtttttgc tttttaactt atatttttgt ttcataggtc ctctatgatt tatgctttaa 30961 agaagttctg tttttatgtg tttccaggat ttgtttcaag atttagagat ccttttagca 31021 gttcttgtaa tggtggtttc ctaatggcaa attctctcag catttgtttg tctgaaaatg 31081 actgtatctt tccttcatat atgatactta gtttctctgg atacaaaatt cttggctgat 31141 aattattttg tttgaggagg ctgaagatag gtccccggtc ccttcttgct tgtagggttt 31201 ctgttgagaa atctgctgct aatctgatag gctttccttt ataggtaacc tggtgcttct 31261 gtctcacagc tcttaagatt ctttccttgg tcttaagttt ggataacctg atgacaaagt 31321 gcctaggtga atatcttttt gcgatgaatt tcccaggtgt tctttgtgct tcttgtattt 31381 ggacatctag gtctctcgca aggccaggaa aggtttcctc gattattccc ttaaacatgt 31991 tttccaggct tttagaattc tcttctttct caggtacact gattattctt aagtttggtc 31501 atttaacata attccagatt tcttggaggc tttgttcata tttccttatt cttttttctt 31561 tgtctttgct ggatggggta attcatagac cttaaagctc tgaatttctt tattctactt 31621 gttcagttct attgctgaga ctttccagag aatttcacat ttctgaaagt gtgtccaaag 31681 tttcctgagt ttttgactgt ggtttcttta agctatctat ttccatgaat atttctccct 31741 tcacttcttg tatcattttt tgaacttcct tgtattgggc ttcgcctttc tctggtccct 31801 ccctgattag cttaataact aacctcctga attctttttc aggtaaacca ggtatttctt 31861 cttggtttgg atccattgct ggtgaagtac tgtaattttt ggggggtgtg gaagagcctt 31921 gtattgtcat attactgggt atctcagccg tggataccag cacctgttcc aatggaggtg 31981 gcggagggtg caatggactc cgtgagggtc tttagttttg gtgatttaat gctctatttt 32041 tgtgctggtt ggtctcctgc caggaagtgg tgctttccag aaagcatcag ctgtagtagc 32101 gtggagaggg actggtggtg tgcagggccc tagaactccc aagattatat gccctttgtt 32161 ttccactacg agggtggata aggaaggacc atcagatggg ggaagggcta ggcgtgtctg 32221 aactcagact ctccttgggt gggtcttgct aaggctgctg tggaggatgg gggtgagatt 32281 cccaggtcac tggagttgtg cacctaggag gattatggct gtctctgctg agtcatgcag 32341 gttgtcaggg aagtggggga aagccggcag tcacaggcct cacccagctc ccacacaaac 32401 tgaagggcag gtctcattcc caccgtgccc tgaccaacag ccccaagtct gtttccatgc 32461 ggagagtgag aagggcttga aaacttgctc aaggctatct gcctcccagc tgtgagagaa 32521 aagggcttta attcttctcc ctgcctgtga agtatgcatg cccaattcac gccctccgct 32581 gagttctggc caggaggctt ctcgccacat tcaaattgtt acaaagttca gctagagaat 32641 tccttctccc tgtggagttt caccccctgc tcctctggcc gatggatccc tgtggtgcca 32761 g~caggaatg ggctgcttgg gtcccagcaa gttcctgggt cctctacctc tgtatttcac ggctctct aacttgactc agctccaggt aaagctggaa acttcacctg caaacagacc 32821 ttcagcctct ccagtggggg tgtgtcttca ggagaggagg gtctaccttt cccacttccg 32881 cagttgggaa actcacagga attttttttt tttaatgtca acagataatt ctacatcttg 32991 gaaaactgcc cttcagaaat gagggacaaa ttaagacatt ccaagataaa taatagtcaa 33001 cattgcatgg gaatttttgg ccagaacaat taggcaagac agaaacaaaa ggcatccaaa 33061 ttggaaagga agaagtaata ttatctctgt ttgcagagga tatgatctta caggtagaac 33121 actgtaaata tttccccaaa atcactgtta gaactagtaa atgaattcag caaaaatgca 33181 gaatacaaaa tcaacacaca aaaatgagtt atgtatctat attggcatta aacaatctga 33291 agaggaaatt aagaaaacaa ttccatttac agtagcattg aaaataataa tattcttaga 33301 aataaactta accaaagagg tgaaagactt gtacacagaa aactacaaaa tgttgctgaa 33361 agaagctaaa gaagacacaa atagatggaa atacatccca tattaatgag ttggaagact 33921 taaaattgtt aagatgtcaa tactacccaa agtgatctac aaattcaatg caatccctat WO 00/09525 PC'fNS99/17712 EPI-109 9II _ 33481 tattaaataa aatcctaatt atgtttttgc agaaatagaa aaatcaaccc taaaattcat 33541 atggaaattc aaggaatcgc aaagaaccaa aacaatttcg aaaaaaaaaa atttttttta 33601 acttggtggt ctctcacttc ctgatttcaa aactacaagc tacagtaatc aaaaccatgt 33661 ggcataaaga cagacataca gactaatgga ataataaaga gcccagaaat aaacccttgc 33721 atatatggtc aaataattct caacaagggt gccaagacca tccaazgggg aaaagaaagt 33781 cttttcaaca aatggtgctg ggaaaactgt atgtccacat agaaaaaaat gaagttggac 33841 ccttaccttg caccatgcaa aaattaattc aaattcaaat tagattaaag acctaaatgt 33901 aagagctaaa actataaaac tcttagaaga aaacataggg ggaaattttc gtaacaagat 33961 ttagcaaaga tttcttgtat ctgataccaa aagtacaggc aacaatttaa aattatatga 39021 gttggactcc atcaaaatta aaaacttttg tatatcaaag gacactatca gcagagtgaa 39081 aaggcaaccc acagaatagg agaaaatatt tgcatatcat atatgtgata agggactaat 34191 atccagaata tataaagaac tcctatgact caacaacaaa aaaaacaaac aacctgattt 34201 aaaaatgggc aaagaacctg aacttcaaag aagttataca aatgaccagt aaacatatga 34261 aaagatgttc aacatcacta accactagag aaatacaaat caaaaccata atgaaatacc 34321 atttcacacc ccctaggatg gctattataa aaaacagaaa ataacaaatg ttggcaa a 34381 tatggagaaa ttggaactct tgtgcattgc tgtaggaatg taaaatggtg caaccactgt 39941 caaaaagagt atgacagttt ctcaacagat caaacataaa attaccatgt atattagtca 39501 aggttctcca cagagacaaa accaataggc tatatataga gagaaagata caagagggga 39561 tttattaggg gaattggctc atgtgattat ggaggctgat aagtcccaca acaggctttc 39621 tgcaaattgg agaccttaga atgccagtag catggcccca ttcaagtctg aaggcatgag 34681 aacccagggg gctgctagag tccaaaggat aaagagcctg gagtgctgat gtctaagggc 34791 aggagaagag tgtatcccac ctgcaagagc gagaaaaatc tctctgctat ttttgttcta 39801 tcctggctcc agctgattag atggtgcctg cccacattga gggcaaatct tccccactta 39861 gtccactcac actcacatgc caatatcctc tgtaaacaca ctcacagaaa caccaaaaaa 34921 taatgcttca cctgttctct agttattcct taatccagac aagttgacac ctaaaactaa 34981 tcatcacacc atgggaccta gcaattccac ttctgggcac aaaagaactg aaagccggga 35091 ctcaaagaga tacttgtata cccatgttca tagcagtatg attcacaatg gccaaaaggt 35101 gaaagcaacc caagtgtcca ttaacagatg aataaacaaa atgtgtattt atatataata 35161 tatatacaat aaaatattca gtcttaaaaa ctaaagaaat tctgacacat ggataacata 35221 gatgaacctt aaagacatta tgctaagtga aataagtcaa ccacagaggg acaaatattg 35281 tatgattcta cttacatgat gtacctagag tagtcaaatt catagagaca gaaagtagaa 35341 cagtggttgt taggggctac gaggagggga tgggcagtta gcatttaatg ggtatgaagt 35401 ttcattttgg gaaaataaaa aaattctgga gatgaatggt ggagactggc gcacaacaat 35961 atgaatgtac ttaatgaccc tgaactgtac acttaaaaat ggctaaaatg gtaaatttta 35521 agttatttat attttactac aaaaasaagg taacatacta aaatgatctc atgggttttg 35581 tgagaatcaa atgagatcca tgtagagaag ccttgtagtc tatatagccc ttcgcaaatg 35691 ttagctcttc ttagtcatta tcactccatt ttccccaatc tgataccatt atccacacac 35701 tttacccagc cacacttacc caacagcaca ctgtttgagt ttgagtgcta tctggtgaat 35761 actcatcttc attttgctaa accctggatg ccatgtgcta gccaacaata tcctattgtt 35821 ctggttctta aacaaaacaa aatctcaaag acttcttcct cttacctagt tttacccaat 35881 gattggcttt gaagcagtcc ttattcagta ataagaggtc accatgccat ggccaagaat 35941 agggcaaatc ttcctccaat tcagttgaac tccctggccg tctagcaaac aacatatctc 36001 ataacacatc ctttgagcag gtgaacaact ctgaaccttc tttgaaggaa caggattctg 36061 ggaaaggaat aaaagaaatg catgcagtgt gtattgagaa taaaatctat tagctaagaa 36121 ataaaaaatg aaaatgctac aacatgatca gttttgatgg actagacaac tctctgtaga 36181 gtagccacag ggctgaaccc tcaaatattc ccagaaagta tagacattgc tgtagaacca 36241 gcctgataat gcagcagtgc agaacttaag aatgatattt ctttctagaa agcagaccaa 36301 ttgatatctt catcctgtta ttgatcagaa tccacgtcag cattcaggtg ctctctggct 36361 acaagtttcc ttagctcttg caggcgctgc tcattgaaga tttctcttaa cacaggtaat 36421 gctaccagtc tcatctggca cctttttcat gcaatgacaa ctatccagga gttgctgcct 36981 ttccagatat cccctgcgag accaatgagg gattttattc catgactctt tgaagaggtt 36541 caaacatgga tcaaacatga agtagtatgt accccagcct tagaaattta atcttttatg 36601 actgggagaa agaacccaag tctctgtgcc ttcacagtct tgaatatctc tgcttgtttc 36661 acttacgttt acctcactca agattcttag tgtcatcgac atgactggtt aagaactcag 36721 gacttttcaa caaagttttc tgccagtgcc ccacaaatca tgactgtggt ctcccaaatt 36781 ctttgattct ccactaggtt ccctttctcc tccattcaaa gccccaaata acatttaccc 36891 tatatattta gtcccgtttt ttgtagaaat gcttctttgc ttgtgttccc cctacctttt 36901 catatcatac ctacatcgtt aactgaggct cagtcataac atcaacaaca gcatgaaaca 36961 tcccaccttc tgtcttcatt ttgctataaa ctggaggcaa aggaaatgct gtcactcagg 37021 gagtatatca atgaagggaa agactctcac aagacaggca ctgaggcagg agtcactagc 37081 acacagtgta taagtgaaat ctaaatataa aaaagcaagc acttgggata catcccttgc 37141 acacacctcc tcttttataa ccagtagagt gaagttggtt gctgaagtca cagaatcaat 37201 agtctatttc ccacagacgg ctgatgatag cagaacaagc cctggctaag tcccccaccc 37261 ttttcttgag tagctcattg ttatgagcca cggacccacc atcaccaggt cacatgttct 37321 gtactctttc ctaaaaacag tgacaaaata tgctgagcca tccatatttc ctcagttaca 37381 ttgagaggca ggagatataa caattaagca gtctctggag ccagagcaac ctgagctcaa 37491 accatgcctt agcttgcttg ttgtgggacc taggcaaagt tactgaaact tctttagaca 37501 tgtttatcaa taaaatgggt acagttgact ggctccaaga tttcttgacc tcttgatgta 37561 tttgccctgc ataattccta agactgtgat tataatggat tttactctta tgattaggtt 37621 ttcacatagc acagttgact ttaatacagg gagattatct gggtaggcct tgcctaaaca 37681 caagagccat ttaaaagcag agttctcccc agctggtcaa aagagagaat ctctggtcag 37741 agattcacag cataagaagg tttcaatgtg ccatcactgg ctctgagatg tagaaaccca 37801 catgtaagga ccaaaaagaa gcccttagga gctaagagct acagccctcc agccaatagc 37861 cagcaaagaa acaaggacct cggtcctaca accacagcca accaaattct gccaacaaga 37921 aaaatgagct tggaagctga ttcttctccc aaagattcca gataagagta caacaccttg EPI-109 9l2 _ 37981 atttcagcct tgtgagatcc taagcaaaga acccactcat gtccacccaa acttctgacc 38041 tacagaactg tgagctaaca aatgagtgtt gtaagccact aagtttgtgg aaatttgtta 38101 cacagcaata gaaaactaat acaatgagga cacagcaagt gcttaataaa tgttagcttt 38161 tattattact aactcattgg gatcagctac acagttgtaa gaaggctaaa gtaaaaatta 38281 tttatgcaag gctggcagtg caacatagca ttcagatcca gggtccattt ggtctaatat ggctgatatt aagtgtttct caaggggaga gacattattg gcattcagtg gggggagggg 38391 ttcatcctgt agaactgcct tggacatggc agtccattta tcatctctgg cttctcttcc 38401 cctagcagta gtcattgcaa caactgaaaa tgccactgta catttccaaa aatgctcctc 38461 cacaagggtt gagaactttg agaactactt taagggaaat ttcataagaa agcatgcgtg 38521 tcttaaatgc tgccataaag ctacctcaat aactacaatg ctactcaaat tacctgaccc 38581 taagaatcgc cagtggcact tgtttaaata taacgattcc caagttcttt ccctggagtc 38641 ccattccata gggctggggt ggagccccag gaatctatac tcttactcaa agaccccagg 38701 ttaatctttt gtttatgtaa gtttgccaaa cactgagtta gaaatatact cagccgtaca 38761 tgcatttagc aaaagttcac cacaacggaa caatgacaca ccaaaactct ttgaaactgt 38821 gccttctaca gagctgtaaa tctccttttg gaccattcca ttacacaagg tgtcctcttg 38881 gtcacacagt gattgcaaat gggactctag agtcatggaa atgggtatac tcttctcaaa 38991 ctttccatct ttaccagaat tacttcttaa agtgatatgc ttcatggtgt aaactagcac 39001 ttattaattt tttctaaata tttatcatat ttcatatact tttattttgg agatggagtt 39061 tcgctcttgt tgcccaggct ggagcgcaat ggcagatctc ggatcaccgc aacatccatc 39121 tcccgggttc aagcgattct ctggcctcag cctcctgagc agctgggatt acaggcatgc 39241 gccaccacgc ccggctaatt ttgtattttt agtagaaaag gggttctcca tgttggccag gctggtctcc aactcccgac ctcaggtgat gcgcccgcct cggcctccca aagtgttggc 39301 attacaggca tgagccaccg cgcccggccc atatactttt aatacatgtg gaattaataa 39361 aaacgtccat gcctccaatt ccgtggctat tttaccgtct tcctttttcg gacaagtccc 39421 tcaaaggtag cgctcttggc tccttccttt gcttatcccc taaccctgtc ctcctgaggt 39481 gccccctgga tttcctccaa ccccggcagg gtctgccttt ccgggatgat acaacgacct 39541 gccctgcatg ccatatccca ggcgcgtggg caccaaagtg tggaaaaacc gatgaatgac 39601 gttttctgtt tccgatactc tgcctgccag aatcccctgc cgcaccgccc caccacgaag 39661 cacatggaac ccacggacta cacgaggaca gaggtctgtt ctccctttac ctctcccatt 39721 tctttaacta tgcttctctc ggctggcatg ccctttcctc atctcactcc acacacgaac 39781 aggtttagca aataatatgc acgctgctgg gacgggccca agcatttccc tcccttgata 39841 gggcggaact aaaatgcaag ccccacagtt gtcagcaaag gacttccctg ttaccatggt 39901 aaagccgctg cgcctttatt gtggttgagg agtacttgca tcaacctaag agaaaattaa 39961 taagaaggaa gtctgcaggc tgaaaccctt caaattagcc tggactcgcc tgcatctggc 90081 tc~g8acaga gttaatctca ggagtgagaa tatagccctc cggtggacgc aactcgcgcc g ggctaac agaatgtctc caggggaggg gctctgcgtc cgttccgccc aggcccttcc 90141 ggctcacgcg ccgtacggaa gcgtgctcag cgctgggctt gtgctccgta cggaagtgtg 90201 ctttggcgca ccggaagccg actcaacaga gctatggcgg gtttgactgt gagagaccca 90261 gcggtggatc gttctctacg ttctgtgttc ggtgagagga attcgttgta gtcaagcttc 90321 ggggagggac tcccctctgc accttctatc tcatgaatcg ctaccggagc cgctgacggt 40381 tcggacgtgc agttctccct gcttatcctg tagggcgtcc aacctggtgg actcatgagc 40441 aaagagatat tcccattctg ccgaggtctc gtaggctttc cgcaatatca gtggggaagt 90501 tagactagcg ttcagcttct gtgcgtttct cctttcatga gcttcaatta ttctctagag 40561 gagaaggctc acggtaacag ctcctcactg tcccgtacta cttctcatcc tctgccccag 40621 aatacagact atatgctgag ggtatagatc ctagtgtcca cttactgtcc tctcctaagg 40681 actttcatcc tttgcttttt atctgtaaca ttttagtgca tcaatagtgg tagcggccac 40791 ctggtgtcct gagatggctt gtaagtgaat gaatgaatga actattaaga tctcctcaga 90801 ggaattttaa aaaggatcga aacgattctg aattatcttt ttggctgaaa taagttgttt 40861 ttaaaaatac gtgtgattat tttagagtac catttgaaag ggacatgaca aagtagttca 90921 gaatactttt taaacatctt tcactacatt catcgtcatt ctcccttaaa tgttgtatgt 90981 gtggaaatac ataggaacct gttttaaaaa ttatattaaa taacattgat attttttgta 41041 gtcactgatg agacttgcag atctttaggt aaataccagt gccaaagtat ttatttgcac 41101 caaagttaag gaaaatctaa cacgtgtcag atcagtctga gaactaacat ttgagagtac 91161 ctacacattt tgtatttagt ttcagtggta tatttccttt gttaagaggt ctgaagaaat 91221 acaatggaat tgggattgga gaacactatt ttgagtctta tatttgatga tataagttta 91281 ctttctcact aaagatctat gttataaact cagaatttta atgttaccta ttttcttcct 91391 tagtggggaa cattccttat gaagctactg aagagcagtt gaaggacatc ttttctgagg 91401 ttggacctgt tgttagtttc aggtgagatc cccttttcct tcatggtggg agcttcttaa 91461 aaatcaccac agatttggct cttagtaata atggcaggtt ttctttactg gtgacttttc 91521 acatacattt tgttcttgta acagctttat tgagatataa ttgatacact atacaattga 41581 catttattct tacctaaaat atgttttttt cgttaaaaat gttttttagg cagggcatag 91641 tgactcaagc ctgtaatccc agcactttgg gaggccgagg caggcggatc acctggggtc 91701 aggagttcga gaccagcctg accaatgtgg tgaaaccttg tctctactaa aaatacaaaa 41761 attagccgcc gtggtggccc atgcctgtag tcccagctac tcaggaggct gagacaggag 91821 aattgcttga acccgggagg cagagatagc agtgagccaa gatcatgcca ctgcactcca 41881 gcctgggcaa cagagcaaga ctccatctca ggaaaaaaaa aaaaaaagtt ttaaaaaata 41941 tttctgtgag gctgtcagag atataaggtt atttatgtta cagtgggccc aattaaagca 92001 tggcaatgtt agcaggaacc ctgtatgtgt gtaacatttg ttcctgacac ttggttctgc 92061 tctccagatt ggtatacgat agagagacag gaaagccaaa gggttatggc ttctgtgaat 42121 accaagacca agagacagca cttagtgcca tgcggaacct gaatgggcgc gaattcagtg 42181 ggagagcact tcgagtggac aatgctgcca gtgaaaagaa caaagaagag ctgaagagtg 42291 agtacaaatc caacttggat gcagtatgag ttagtaaaga tgtaacaatg aagattttcc 42301 atttctgata tgttttagaa tatgctgaaa tggttagcca cgcagcttgt ttattacttg 42361 actgacctga tgtgcctgag ttaggcaagt attatatata tctttttaaa aactttttat 42421 aaattttttt tcaagtaatt gtctgaaatt tctataccct tgctctggat ggagcagggc )=YI-109 913 _ 92981 aaggcctcaa accgtttcaa aactgttctg gcaagcactg tagggatgca tagggtcact 92591 gcagacctaa gcatgctgga ggcttgctag taagtgtata tctttaagaa acagataaag 42601 ttgacattag aaattcttca gttgctccag cctgggcgac agagtgagac tctgtctcaa 42661 aaaaaaaaaa aaaaaaaaga atttccattg ctaaggagtt atttccagtt aaagatgaat 42721 tcaaattcat caagccatta gtagtactaa ctgtggcatt agtcattcct gtcactcttt 42781 tcaggaattt ttgaagttag cgtatttttc tcttttaacc ttttgtttct gaaatgactt 92891 gttaaaagaa gtcaatgtgc ctagttctct aacttaggtt aacattgtcc ttccatgtga 92901 tcatgatccc cagctttcct ctgagaacag aaaatacact ctcactttcc tccacagaaa 42961 caagaggctt tcacatcatt tatttctcag ctctggagaa tctaaaatta tcagctggtt 93021 cttacagcag ccctgaaaag tagatatttg aaatgattta gctttttgtt ttgcctccct 93081 aactttcttg tactttcttc ttgattaggc cttggcactg gtgcccctgt cattgagtca 93141 ccttatggag agaccatcag tcctgaggat gcccctgagt ccattagcaa agcagttgcc 93201 agccttccac cagagcagat gtttgagctg atgaaacaaa tgaaggtggg aggaggcatt 93261 aggttatgaa taaagcaaat cacatcaggt tttcaaggag ttacttgaat tagttccctg 43321 agctcaaata gaaattgtct gtagaccacc atttcttgca ccttcaatat tctgtatgta 43381 cacagtatat tttacatttt gtacaaagag ctttctattt ttgtacacaa acacagctat 93941 ccaaacaatc cagctggagt tttgtggccc atagatgtca gatgtagata ttaaaatttg 43501 gcttttttcc taaatgataa tatcacagta tttgaaatgc ctctttcttc tcttgcctgc 43561 catgaccaag gtttttttgt gccatgcaaa aactaatgat aaagagcctc ttgaatatta 43621 catttctcag aggggaatgg ctctaaatca ctatcagttt ctaagtcata agtattaaac 93681 ctgaatctgc ttatcttctc agctctgtgt ccagaatagt ccccaggagg cacggaacat 93741 g~tggatccg aaccctcaac tggcttatgc tttgctgcaa gcacaggtag tgatgagaat 93801 t t g gaaattgccc tggtgagtgc ttctggttct tttatggaaa tggtcgggta 93861 aaccttgaat gggataggaa ctacctgatt gctttgttaa acagacagct cataggtttg 93921 tcttttcact ttttagaaaa ttctgcatcg ccagacaaat atcccaacgc tgattgcagg 43981 caaccctcag ccagtccatg gtgctgggcc tggctcagga tccaatgtgt caatgaacca 99091 gcagaatcct caggcccctc aggcccagtc tttggtaggg ctttatccct taacattttt 94101 ttgtatctgt cttagaatgt cattttcttt ttaggagaat atattgaaag aagaatggtc 94161 aggaaccaga gatgataatt tcaatttcca ggcataaaag caatttccag gttgcagagc 94221 acatgacatc tgaatgaata tagattcgat tccaagtttg taaaacaaag agatccttcc 99281 cgtatgccct tttcttataa gctaactttg tgtgtatgtg catgcctggc actgtggttg 99341 gcacttcgtt attccatatg cattatctca tttaatcctc aaagcaattg tatgaggttg 94401 gcactcttat tatctccatt cttactgatg aaaaaagtaa agcttgcttt caaagcatga 94461 cacaaaacct taaagccata aaaaattgat acatttgaaa actaaaaaat ttctatataa 49521 agaaaaaaat aagtatcaaa gacatgacaa attgagaaaa agtatttacc acacatgtga 99581 tggaaaacag actaataaag agcccatagt cattcacaag aatgtttatt gccttagagt 49641 gaaaaattgg aaatgtccta aatgtacgtc agtggaagaa tggagaaaat gtgtggtaca 99701 ttcatccagt gaaatactgt acaacagtta aataaactac acgtatcaac atgaatgact 99761 ttgaaaaaca taattccata cagcagttaa gatgaactag gatacataat atcaacacaa 94821 ctccaaaaca gtgacatacg gacatgaaac taagtgaata tggatgcatt cccgaaatgt 49881 aggatatatg tttctgcata aatccccaaa atatgtggaa tgagttgcaa aataatatat 49941 tgagtatgta atgattcata taaaattttg aaacattaag aagacgtctt agtggtcatc 45001 aaaggagaag agagcacagg atgcaattgg ggaagaccgt acaggccatt ggtttatttt 95061 atttacttat ttatttccta agctgggtgg ctattttatt ttctatatga tttgtatatc 95121 tgtaattttt cataataaat tttaaaaggc ctcctataaa ttagtaagaa aatttccaat 95181 aacccagtag aaaaatggga aatagacata aatatttcac aaaaggagaa atataaatat 45241 ataaaaattt attcaacttc aaaataagat aatgtaataa attatcattt atatatgtaa 95301 tgttataaga taatgtaaat agaaactaca ataagctacc atttttcatc tctcaggttg 95361 gcagaggtac agggcaggga ccagcaaaca tttttctgta aatgatcaga cagtaaatat 95421 ttttggcttt gcaagtcaca ggatctgcca cagctactct gccatggtag tatgaaatca 45481 gccataggca ataagtgaac aagtgtgtgt ggttgtgttc cgttaaaagt ttgtttataa 95591 aaccaggcag tgagcccgat ttggcccatg ggtcatagtt tgccaacccc tgctctaaat 95601 aaataaatac attttcagag atagaaaaaa aaagctaagg cccagagagg ttagctggtc 95661 caaaaattga cacaattata agtggcagat ctatttctga acctggtttt atctgacctc 95721 acagccagtt ttctcttaac tactttccta tacagctctt ccttttcttt tgtagagttt 45781 ~tgtgttcctt aaacgtatat gtgatttttt ttatataact tggcttttat tctttattta 95891 ttgagctgtt tctaattcaa gggactactc agttttttgg ggaatgcaca gatgaaaaga 45901 tgacattctc tttttctcaa cgagttttaa tgtagcattt aaaaaaatat atttcacatt 95961 cccccaaaac cagaattata tctaaggaca ggagtgagaa aagattggtt aaattaaaaa 96021 aaaaatttaa ttttaaaaat gtggactacc agcagttgtt ttttttaaaa gagtcccagt 96081 ctccttttat gtttcttggg tttagggctt tttttttttt ttttttttac tcttattggc 96191 agccccaatc atgaagttaa cagtaggtgt tatgtgctgc cttgccacac agataagact 46201 tgtcaatctc tacattgaga atatgttcca tcttaaccgt gttccatata accaggctca 46261 tgacgtatat tgcttctgtg gagtttaaag tgtgtgacaa atctaatgct gcataagaca 46321. tgccatacaa aaaggatgtt tagtagtgta tttggggctq ttcatttgaa gaggactttt 96381 aaggtcgtag acttagtata ttgagtatcc acagaggcat atacatactc tgtttttttt 46991 gcttggtcag ggtggaatgc atgtcaatgg cgcacctcct ctgatgcaag cttctatgca 46501 gggtggagtt ccagcaccag ggcaaatgcc agctgctgtc acaggacctg gccctggttc 46561 cttagctcct ggaggtaagt ttcatttagt cttcaccatt tcagtacttg ctaaagtttt 46621 gtcatagcca ctgttgcagt gcagccaaat atgataatgg gatccttagg taaaattaat 46681 acacagctag aaagtatata tcttaggtgg aggaaatagt agatttctta cgttaaatcc 46791 tgtatgtcta attataagaa cagggaaagg gacagtaaag tgaaagagca tagtaaaact 96801 tccaagttaa caagggggaa aatggaatga gtggaaacaa aatcaagcca gcaaaaatag 46861 agaagaggaa aaaagtaaga gacagtgtaa aataagtaat aataaatgta gagtaagatg 46921 gaaggaataa aaactaatgt agttgttact ctgctaaata tgaatgaact gtcagattag EPI-109 914 _ 46981 gttcaaaagc tcatgaagaa aacagacaaa aaaatacaag gtcacatttg ttatagcata 47041 ttaaactgac ataaaattgt attttaacaa acataatcag aacaaacaac aaaagggaaa 47101 aagagaaatt taaaagctat gtacatttat tgaaaatgta tagatcggca attaataaga.
47161 gtattgctca tatacttgta actgttcctt gttcaacaat tgtaactaag aagattgagt 47221 gaaataatga ttccccatat gaaacatctg tatgaacaca tgatgtatta ccaatattta 47281 aagttttttt atgtaacaaa cttggttttt gttaatttat ctaatctagg gtaggttgag 47391 tacaacacta ctcatggaga atgatttaat tctaaattgt tctgttctgt agagaatcca 47901 gtctgcagag ctaagttgat gaggaatgga agaagagatt ttttgaagaa atttctgcaa 47961 actcaggaat tttttgtatc tactttagga ttgttatgta tctactttat cctaatagag 47521 ttatacttgt atttaaatta tctttcatga caggaggtcc atgggtaagt gacattgttt 97581 tcctgtatta tagaagagct tcctgccaag agtttggtaa ccaatgaaat gaattattct 97691 tattgaactc actattctgt cactgaaaca taaagtacaa attgtaaata tactaacaaa 97701 ccccatcttc tctctcattg cattgttgaa tatcttcctt tgtaggtttc tgcttgtgga 97761 gcagaatgag gaaatttgta aactcagcca ctgttctaat ttttcttttc cgctgttcta 97821 attggtgttt tttcttgtct gccctttatc ttctaggagg aatgcaggct caggttggaa 47881 tgccaggaag tggaccagtg tccatggaac gggggcaagg taaataaata ttaatgtctg 97991 actaatgtta attggtcatg gaagtgttcc acatccacag tatctaatat ggcagccact 48001 aaccacccat ggctatttca atattaagtt aattaaaatt aagtaaaatt taaaactcag 48061 ttcctcagtc acaatagcca cattccaagt gctcagtggc cacaggtgac tagtggatac 98121 catacaggac attacagata tagaacattt ctatcatcgt aaaaagatct attggacagt 98181 gctggtctag actttccacc tggtgattca gagtccagct ctacaagaat tgataatgaa 48291 gcaagtggat cgtttgtttc ctgattccta gtctaataat tccactgaca tgttctctct 98301 ccctgtatgg atatctgttg actgagtaag gaattttaat aatgagcatg taaatatgtg 98361 gctgggtatg tagaagacta gatttaaacc ccagagaaaa ctgggaggga atcataggtc 48421 tgtaacgcct acttaatgaa catatgttgt accgtggctg tactgctata tacaacagta 48481 gctgctgctc caaaatctcc atgttgtttc ttcatgttac tggagtttga aggacaagaa 48541 agtgcagtgg ttcagttgga aacaatgtta ggaggagaga tcgtaagaaa agagaaggaa 48601 ctgagtgcat actatatgcc aggcacttta attttcataa ataatcttgt gagttaggtg 98661 gcagcacctc agttttacag gcaaagagtt ggaagctcag aataagttac tttctcaagg 48721 ggacaaggta agtaaatatt aatgtatgag taatgtggac tggatttggt gctcttattt 48781 tctcttccaa ctagtaagtg gcagagctaa gattcagaag tctttgactc cagaatctgt 98841 cctctttctg tcactccaca ctgcctctgt taacttccaa gcatattctt cagtgtcttc 98901 tactcttatt ccttgggaat aaaatgatgg gaaagactgc tttggacaag catagagaag 98961 cttaaggttt tttcttttgt agcatatggt ttataagtgg aacccattta aaaagcaaaa 99021 tattggccag gcgcagtggc tcatgcctgt aatcccagca ctttgggagg ctgaggtggg 99081 tggattgctt gagctcagag gtttgaaact agcctagaca acatggcaaa accccgtctc 49141 tataaaaaat acaaaaacta gttgggcaat ggtggtgtgc acttgtggtc ccagctactt 49201 gggaggccga agtggaagga tcacttgagc ccaacaggtt gagactgcag tgagccataa 49261 tcgggcacca ctgcactcca gcctgggcaa cagagcaaga ccctgtctca aagaatatat 49321 atatatacac acacacacac atatatatac acacatacat acataaacat taatatacaa 49381 gcctgtggtt tttacactgg ggttggttgc tgaagtgaca gaattaactt tttcttgtta 99441 gaagtctgac agcaggacaa actccctggc caaatatctc atattttctc taagcatcca 99501 atgcttttgt gctattgtac atccctctat ccccaccgca ccactgtcaa tagatcatat 99561 atgttcccca gagtatttct gcagtaatga gaaggtatta gggtttcagt catacttctg 49621 cctgtcatgg ggccagccct caatccatca ggttttagct gtttaacgca tacttgcaca 99681 agacatcttc ctattatagt tatcttcacc tttttgtcag aaattggcaa agggaagtga 99741 ctcatgtttt gagggtattt ccaggatgtc ttcatgcaga gactaagtga gatgagcttt 49801 cttttatagt ttccttcagt acccagcaga ggaagcaaga gtcttttcgt gtgtgcctag 49861 tttgtcttac ttttcctgaa atccatgctg cttttaatgc tgaaaggaga tggagatgtt 49921 tgagaagata cttcttgctt ccctgccatg tttgtttagt gtcggttccc atgtcatctc 99981 attagtcttt gtttgctgtt gtcatgatgt ttattatcaa agacttgctg tggcagagta 50091 tttcttgtgg agtgatattc tctttcatca tgtaaagttc attcactgca tttccccatc 50101 tgatacattt ttgacagcag aaatttttgt gctttaaaat gtgacaaaaa tagaattgcc 50161 gtacttcagt tatggccgtt tcagaatgaa tcttgccttc cagattcagt gcagtttctt 50221 ttatgttttg cttctgaaac tacatttatg ttctttgcat aactagaaga ttcaaaacta 50281 tcctttttat atattttttt cctaatgatt tcataaggag acctaacgga aaactagtag 50341 cagaggtgaa aatcgaaaat gtcaggttat tcccacctag atcaaaccag tgcccccatg 50401 ggattccctt tcaaaagcta tctggtcaaa atggaactat ttcagagacc caaaggagct 50961 agtgtagttt agggagattt tgtagcctgg agcaagccga tgaactcttg gctttttaac 50521 ttatatatgt aaatctcaat ctccatgtgt gtgtgtttct gcgtgtgtat gcaagctatt 50581 ttaagtgtct gctctttctc cttttgaact tactgcttac ctaggaaccc tacagcactc 50691 gcccgtggga cccgccgggc ctgcatcaat tgagcgagtt caaggtaccc attgtatctg 50701 tgggtttcct tttgcttgtg gtgttcaggg tgggacgttg agaggaaaag agctgcgtgg 50761 cagtcatcct cgcgttcaga acccaaaagg gtagtgtttt tgggtttttg tttttttaat 50821.tttttcctgt tgaggccaca agcctaagat tgacctcttc acacagggca gagaacatgg 50881 atgatatggg catctgtccg aggctgtact ccctccctac tggtgtcagg aggcttggat 50991 ggaatagcag tctgtaagga gacagcgggt tcttgcagag ccatggcagt gttcacatat 51001 gccaagactc tacctctgtt ttgtgactct ggtccttgaa ctaagattga ttagaaggaa 51061 aaccaggagc ataagtttct ccaggtcgca gtgctagtcc ttggcaggtt gctccccagt 51121 ttgctcttta tataattcca tccatacctc tgacatggca cagattctgc ctacaccctg 51181 cttctgttct tgagctgcaa gaggattctg ctgtggtgag gtttcaccca ctctaaggtg 51291 tctgaattat gttgtcagtg gtatatagag tcatttcttg tttgcttatg tgtctttcac 51301 agcagtaact ccccgtttgt ttccctgtca gtgccgatgc aagaccccag agcagctatg 51361 cagcggggat ccttgcctgc gaatgtccca acccctcgag gcttgttagg agatgctccg 51421 aatgatccac ggggaggcac tttactttct gtaactggag aggtagagcc taggtaagca EPI-109 915 _ 51981 ctaacataga aggaaacagt tgaagaaatc agaattgtcc cttcttccct gagaacaaaa 51591 tctttctgta ccagttgtac ctgtttgcct acttcaaaag gtagatcaat attcatggcc 51601 actgtccaag ggtaagcact tctcctaagg cagaactatg tacttgagta tgtcattttg 51661 agctattata tttttagaaa ttggaaattt tagtatacat acttgaacag ggaaatttat 51721 agtagtggaa atattaataa tagcaataat aggccgggtg cagtggctga cgcctataat 51781 cccagtactt tgggaggcca aggtgggtgg atcacttgag gtcaggagtt cgagacctgc 51891 ctggcctaca tggtgaaatc ccatctctac taaaaataga aaaattagcc gggcgtggtg 51901 gcgggcgcct ataattaca.g ctactgggga ggctgaggca ggagaatcgc ttgaacccag 51961 gaggtggagg ttgcagtgag ccgaggtcat gccactgcac tccagcctgg gcaacaagag 52021 tgaaactcca tttcaaaagt aaataaataa ataaaataat gatagtaata ataattgaca 52081 ttaatgggga tcatgcctct gactctgctc tgagtacttt acttagatca tcttattaaa 52141 tccacaagat cctgtgagat ggataccatt attagtccca ttttacacgt gaaactgatg 52201 tgtggaaaag ttaaataatg tgtccaatat cacacagcta ataagtgata gagcctagat 52261 ttgaacccat acagtctgaa tccagagctc atgttcttat gcattgttct gcaaactcat 52321 acatataatg aatattcgtt gattcctccc taattatgaa ccaaataacg aaattctaga 52381 atacatggat ttatatctct gtagcttttc ttccatctat ttggtgttat tttcttgtta 52441 gtattcatag actacatcag ctctttgttg gatgtttact tactgatctg gttggtactt 52501 tgttgttgtt ttgttctatt ttaaaataca acgtttttct ccatctccag aggttacttg 52561 ggaccacctc atcagggtcc acccatgcac catgtccctg gccatgagag ccgaggacca 52621 cccccacatg aactgagggg agggccatta cccgagccca gacctctaat ggcagaacca 52681 agaggaccca tgctagatca gaggggtcca cccttggatg gcagaggtaa ggggagatca 52741 cattgcaaat gccataatga actcaactgt cttaggctct aatctgggat aaagaatgct 52801 ggaacagtag gtttgcaagc atctttaagg tttatccaca aatctgagaa actggggagg 52861 agacaatagt ctcatatgtt aatagctgag gggacaaatg tgactagaag agatttctat 52921 ctttcttgga ttgttcatca ttcttgcagt acatgcaagt agctacataa tggttttgtt 52981 acatttttct ttataggtgg aagggatccc cgaggaatag atgcacgagg gatggaggcc 53091 cgagccatgg aggcaagagg gttagatgcc agaggattag aggcccgtgc aatggaggcc 53101 cgtgcgatgg aagctcgtgc aatggaggcc cgagcgatgg aggcccgtgc aatggaa tc g 53161 cgagggatgg aggccagagg catggatacc agaggcccag tgcctggccc cagaggacct 53221 atacctagtg gaatgcaggg tcccagtcca attaacatgg gggcggttgt cccccaggga 53281 tccagacagg tatgtgtaac actgacttct ggcatccaag tgaaatcttg atctattcag 53341 gaattgatta ttgagcctaa ttattactgc cttctgactt gggctgtttc ttagcttgtt 53401 agaaagggaa gacttggatc tccctgtagc ttctctgtcc cttagggtgg tgattttctg 53461 gctatcagga ttgtagttca aaaaaaaaca accttatccc acaataaata gctattcatt 53521 tggagcagag cccctgaaaa tttaggggtt agaaagtagt cttgattggg gtacaaacca 53581 acatcatgta cacggttttt tccaagatat acttgcccgg atctcatccg aggtataact 53691 cagaatctct tattagtagg atctgagcat ggatagtttg aaaaacttcc cccaaatgat 53701 tctaatgtga accctgactg ggaaccactg ggttagagta tatgaagagc tgttagtggc 53761 catttagata atcttaggtt tagagagacc tgtgttaatt tattgtcatc acatagccta 53821 agtgaacagt ggaatgtgaa aggcagttta ttaataatca ccttaaaagg tgtggaaccg 53881 aagtcttgtc tcctctcttt tatttggatc tctctgcctg tgtgtacatg ctccctcttc 53941 atctcgactt ggttgtggag aggtggtatg tgtgtttctt ccgtgagttt ttatatgctg 54001 gcaccttcat ttccctctaa ctgctccacc ttccttttcc ccccttcctc tgcgtacttc 54061 tctcttcttt ttttatgtgt cttcctcccc atgtctgtgt gtatgagaga gagaaagata 54121 atggcagagc tggaatggaa tacatcaatc atctaattcc ctcagtttat agatttggaa 54181 attaaggccc aagaattcag gtgacttgac caaattcaca tgactaaaaa gtggcagagc 54241 aaggaacaga agccactact ttttccactt tactactctg tcctgttatc tgcacatttg 59301 tgtgtgtgta tatgtgtgga tatgtgtcta ccccctcctc tgtaatatga aatacaaata 54361 gagggttttt ttgctatgtg tagaataaaa ctgttctcta ttgtgtttga agtgtttgtg 59421 ggccttgatt tttattgtac tctctatggt cagtagccta gtaacagaaa tggtttttat 59981 gcattcattc tgtcactcag caaatattta ttgagcacct actatgtacc aaacatagat 54541 ctaggtacgg gggatactgc agtgtgaaca gaacaaagcc ccttccccca tgggcttaca 59601 ttctagttgg gaagacagat aacaaacaaa taactacata atgcgcttac ataattttac 59661 tggtagttct atgatgcaag acattgcaag taagggttgg aagaacattt ctggataata 54721 ttttgctcct ttctctctgc tggtacttga acttattacc ctaatactag gtttatacca 54781 tttttattag tagattcgat aaagccaatt agatctgagg caagagaaaa tacaaatttt 54841 atcttcaaac ctttaaaaaa attttaaatt aatatattaa cttataaata tatatattcg 59901 ttcatctata aaagatatat gtattaagaa cttcaagcca ggcatggtga catgcacctg 54961 tagtgccagc actctggagg ctggggcagg aagaccattt aagtctagga acttgaggct 55021 gtggtgcatt ctgatcgcac ctgtgactag ccactgcact ccagcctggg cagcatatta 55081 gactcccatc tttaaaaaaa aaaaaaaagc cagggtagaa tcctgtagtc ccagctactc 55141 tggaggctaa ggcaggagga tcagtagagc ccaggagttg gaggcccgcc tacacaagat 55201 agtgagacca catcttaaac taaaaggaac cttgcttcct ctcctatgct tgtctcccct 55261 gtggccctct aggtcctgta gataatcact tttattagat ttttcatgtt actttctgga 55321 aaacatgaat atatattatt tttccccttt cactgttcta tacctttttt ttttttaact 55381 taacaacatg tccttaattc atacttttaa attagatttt aaaattaact ctagtccact 55441 tagttagaaa cttgtgggca aaaggcttat tattactagg gtgattatat aatttatcat 55501 ctaaaggaga acatgaaaga aagtgctgtt actttacttg gaggcaaaaa cataaactgg 55561 gactatctta gggaaaccaa gatgtatggt cacttttgct agtacttgtc tgcctagaac 55621 aagcacacct agaaacttaa aatggccgtt attgagtggt tagatcacaa ttacagtacc 55681 tcagattaaa gcttcaaaaa gattatactc aattccgaat tgtgctgcta taaactcatg 55791 tgaccaaaca ccacctgttc cccaataacc tatggaaata aaaaatttta aaaaaaaaga 55801 ttatactcat aggtgtttca gacccataat agctcgttaa tgttcagact ggtctctgga 55861 aacttgtctc tggtttcagt attgataatg aacagaacag tgataatatt ctagcagtct 55921 atacaaatct gtactaatgt ttcatctatc cattgtcttt gggaaatgag ttaatgcatg EPl-109 916 55981 taagtgaatg ttccagataa tagaactatt ctaccaagtt ttttaacttt tttaataaaa 56091 aattataaaa agtatttgat atttcctttc ttgaacagga tacaaaaaaa tagtttaatc 56101 agttttgact actcaaggtc atcattgaat agattcatta ttgtctatac cgtaatataa 56161 aacatagtta tctcctgttt ggtttctggt ctccttcact gtcaggccgt cacctggctc 56221 ttcatattac tgaagtggta tctgctccta acagttattt atccgtattt cttttatgtt 56281 ttgctgcttc taatctgctg ggtaagcagg taacaagttt gttaacaata tgtgtttatt 56341 aagagagtac ctaagctctg ggtgaatgcc tgagtgtgaa cataatgctt gtatagggac 56401 attctaacag ttagatttgg tactcaagag gtcttttcct tgggttctgg tagtcttgca 56461 aagggttgaa ctcattgaag atcttaagta ccagtaagta tgatatcact gtacttggtt 56521 ttttcactcc agtcagtcat attttttggt ctacatttag cagaaagcat ctgccatatg 56581 ttc (2) INFORMATION FOR SEQ ID N0:2693:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2693 1 ttcagttcta gcgtcaaccc ggtgctctac gtcttcaccg ctggagatct gctgccccgg 61 gcaggtcccc gtttcctcac gcggctcttc gaaggctctg gggaggcccg agggggcggc 121 cgctctaggg aagggaccat ggagctccga actacccctc agctgaaagt ggtggggcag 181 ggccgcggca atggagaccc ggggggtggg atggagaagg acggtccgga atgggacctt 241 tgacagcaga ccctacaacc tgctgccctt ccctgtccct ttccaccccc cacccaccct 301 ccagaggtcc tcccgacggc catgaacact acatcttctg cagcaccccc ctcactaggt 361 gtagagttca tctctctgct ggctatcatc ctgctgtcag tggcgctggc tgtggggctt 421 cccggcaaca gctttgtggt gtggagtatc ctgaaaagga tgcagaagcg ctctgtcact 981 gccctgatgg tgctgaacct ggccctggcc gacctggccg tattgctcac tgctcccttt 541 ttccttcact tcctggccca aggcacctgg agttttggac tggctggttg ccgcctgtgt 601 cactatgtct gcggagtcag catgtacgcc agcgtcctgc ttatcacggc catgagtcta 661 gaccgctcac tggcggtggc ccgccccttt gtgtcccaga agctacgcac caaggcgatg 721 gcccggcggg tgctggcagg catctgggtg ttgtcctttc tgctggccac acccgtcctc 781 gcgtaccgca cagtagtgcc ctggaaaacg aacatgagcc tgtgcttccc gcggtacccc 841 agcgaagggc accgggcctt ccatctaatc ttcgaggctg tcacgggctt cctgctgccc 901 ttcctggctg tggtggccag ctactcggac atagggcgtc ggctacaggc ccggcgcttc 961 cgccgcagcc gccgcaccgg ccgcctggtg gtgctcatca tcctgacctt cgccgccttc 1021 tggctgccct accacgtggt gaacctggct gaggcgggcc gcgcgctggc cggccaggcc 1081 gccgggttag ggctcgtggg gaagcggctg agcctggccc gcaacgtgct catcgcactc 1191 gccttcctga gcagcagcgt gaaccccgtg ctgtacgcgt gcgccggcgg cggcctgctg 1201 cgctcggcgg gcgtgggctt cgtcgccaag ctgctggagg gcacgggttc cgaggcgtcc 1261 agcacgcgcc gcgggggcag cctgggccag accgctagga gcggccccgc cgctctggag 1321 cccggccctt ccgagagcct cactgcctcc agccctctca agttaaacga actgaactag 1381 gcctggtgga aggaggcgca ctttcctcct ggcagaatgc tagctctgag ccagttcagt 1441 acctggagga ggagcagggg cgtggagggc gtggagggcg tgggagcgtg ggaggcggga 1501 gtggagtgga agaagaggga gagatggagc aaagtgaggg ccgagtgaga gcgtgctcca 1561 gcctggctcc cacaggcagc tttaaccatt aaaactgaag tctgaaattt ggtcaaaaaa 1621 aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1681 a (2) INFORMATION FOR SEQ ID N0:2694:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2694 1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaatt catggtggtg ttagaaatca gaagagaggc tacctttgtg 241 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301~gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 981 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 541 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag WO 00/09525 PCT/US99/177~2 EPI-109 917 _ 961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgacLgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa ' 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1741 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2401 aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2941 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3921 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3981 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3591 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3891 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 9021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 9081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 9261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 9321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 9381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4991 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 9501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 9621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 9681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 9741 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801.taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 9861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 9921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 9981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5341 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa EPI-109 gig 5961 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5941 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6291 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6421 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6481 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6541 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6891 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7141 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7441 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7741 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcaccttt cacatacatq tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8901 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag 8961 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8691 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301. acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9921 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9981 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcaa 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9891 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt 9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt .
10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10941 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11041 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11341 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11961 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11691 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11991 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12421 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12481 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12591 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12841 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13191 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13491 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14091 aagtccgtcc ccttcttaat caatgcagag gctacccact ccacattacc ttctcttcaa 14101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 19161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 19221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 14281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 14391 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 19901 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat 14961 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 14521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 19581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 19641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 19701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 19761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 19881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 19991 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15291 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15481 tcattccaga caccagccca acttgaactg tgccccaa.aa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16491 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct 16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16791 aatatcaccc cttaccacaa aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17091 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17641 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18291 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361.atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18981 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18541 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18891 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19441 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20041 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20391 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20901 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20961 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagc't ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20991 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag 21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22441 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22791 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23341 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23901 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23641 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23991 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 29181 cagaggtaag gctactcact gtttaaaccc ctttagtgat atcccaaaag acctcaagat 24291 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 29361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 29421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 24981 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 24591 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 24781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 24891 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 24901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25441 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa 25501 tctgccatct catcctacct gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26391 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26961 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27291 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27541 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29041 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29901 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29961 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29641 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29991 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30291 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30981 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30541 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaa't gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30891 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31141 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31941 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31741 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32391 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat WO 00/09525 ~ PCT/US99/17712 32961 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33291 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33921 actgacgcct ggatttgaat cctagccctg ccacttgata accatgtgcc tttaaacaag 33481 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33541 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 34141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 39201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 39321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 39441 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 34561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 34861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 39981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcaattcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35391 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35461 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35991 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36241 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacct caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36481 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36591 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36891 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt 36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37491 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37741 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38091 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38391 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38401 ttgtagggac tcagaaaata cctgttgtat gaaaagagca ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38991 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39291 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39421 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 90021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081.tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 90321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 90381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 90991 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 90501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 40621 tcctcctcct tcttttccac caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40791 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tggacgtcct tgttagtggc 90861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41041 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact WO 00/09525 PC'TNS99/17712 91961 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 41701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 91761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 91881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41991 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 92001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 92121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 92291 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 92301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 42421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 42481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 92541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 92601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 92661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 92721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 42781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 92841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 92901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 43021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 43081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 43141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 43201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 93381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43941 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa 43501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 93561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 93741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 93801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 93861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 93921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 93981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 49091 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 99101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 99161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 44221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 44341 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 49401 aatggggaaa aacgtggagc cagggagact tgtgaaagtg ccagtgctcc cactataccc 44961 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 44581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 44641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 99701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 49761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 99821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 44881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 94941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 95001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 95061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 95121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 95181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 95291 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 95301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 95361. attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 95421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 95481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 95541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 95721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 95781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 95891 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag WO 00/09525 PCTNS99/i7712 95961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 96021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 96201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 96381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 96501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 46561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 96621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46791 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 46921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 46981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 47091 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 97391 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 97401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 97961 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 47581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 47641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 97701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 97821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 97991 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 48241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 98361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 48421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48981 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48591 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 98601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 48661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 98721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 48781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 98961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 99021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 99081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 49191 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 49201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 99261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 99381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 99441 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 99501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 49561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 99681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 99741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 49801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 49861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 99921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 99981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggq gcagttgata 50391 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt 50961 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50941 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51291 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51591 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51891 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52191 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52441 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat 52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa 52791 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53391 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53401 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53461 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 59001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 59061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 59181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 54241 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 59301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 54361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga 59541 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 54661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 59721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 59781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 59841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga 59961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56041 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56341 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56401 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57241 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57921 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57481 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57591 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58141 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58791 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59091 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59391 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59901 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc 59961 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca caacaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59691 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt qttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60421 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61441 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62401 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62961 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361.gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63421 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63591 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63891 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga EPI-i 09 931 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 69021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081_attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 69141 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 69381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64941 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 69501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 64561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 64621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 69741 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 69801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 64861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 69981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65091 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65391 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66291 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66921 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66981 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66591 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66841 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67141 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 67441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67791 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68091 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68341 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt 68961 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68991 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69921 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69591 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70141 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag 70441 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga 70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70741 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71091 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71391 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71901 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71691 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga ?1821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72291 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72421 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72981 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72541 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73441 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 74281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74391 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74901 tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 79461 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 79521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 74581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 74641 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 74701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 74881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 74941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggaqagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75291 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75921 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76441 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctaga atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77391 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca WO 00/09525 PC'T/US99/17712 77961 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78981 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78591 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78841 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901 ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaaq 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79741 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80391 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80901 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80461 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80991 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81481 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact WO 00/09525 PC'T/US99/17712 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82941 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83091 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgtg aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83401 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa 83461 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83991 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc 84001 accatgccca gctaattttg tatttttagt agagacgagg tttctccacg ttggccaggc 84061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag 89181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa 84241 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 84361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 84421 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 84541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 84601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt 84721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg 89841 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 84901 tgattgcaga ctagacattt tgaattaaac attatagaga ttctggattc tcgagagagt 89961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85191 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtgccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85941 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgb ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85791 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt B5861.tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatqaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86391 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86901 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc 86961 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86941 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgcca'c tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87421 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87981 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87591 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87841 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901 gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88141 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88441 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89401 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89641 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90241 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361. gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90921 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90981 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90541 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90891 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91141 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91441 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92091 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92391 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401 caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92461 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92691 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92991 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93421 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93891 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 94081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 94201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 99321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 94381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94441 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 94501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 94621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 99681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 94741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 94801 cctttgacct agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 99861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 99921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 99981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95041 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95391 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95401 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca 95961 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95691 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95941 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc 96291 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96481 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96591 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97141 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac 97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg 97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct 97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca 97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag 97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc 97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat 97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa 97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt 97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag 98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta 98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat 98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc 98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat 98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat 98341 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga 98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac 98961 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca 98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat 98581 aggacacata aaatcctaga tctcacagaa ttgacattec agagagggaa aggtagacaa 98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa 98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca 98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc 98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa 98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag 98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca 99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta 99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat 99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct 99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg 99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta 99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg 99361~ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt 99921 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt 99981 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag 99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct 99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc 99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc 99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata 99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa 99891 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta 99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca 99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100141 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100491 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101091 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt 101341 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 101401 gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101961 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101691 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101941 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca 102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaagaa acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102291 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102921 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102481 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102541 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103191 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacatcaaa taaggaaata 103991 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861~taataaataa aaataaaat~a tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 104091 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 104161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 109281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 109391 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104401 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc WO 00/09525 PCT/US99/177.12 EPI-l09 940 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 109521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 104581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 104691 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 109701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 104821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104991 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105291 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105921 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105591 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105891 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aag,ggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106491 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106791 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107091 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107401 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107461 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107991 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108921 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108591 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108891 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta EPI-l09 941 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109441 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110041 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110391 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110991 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111241 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111921 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111481 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112191 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113091 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113401 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113691 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 119001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 119061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 119121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 119181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114241 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 114301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 114361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 119921 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 114481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 119541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 119601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa 119661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 119721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 119781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 114841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115141 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct ccctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115441 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa 115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggctt tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116391 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116901 aatggctctt gtgagcacca aatcattgtq agaaggaaaa cccatctctt acagccccct 116461 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116691 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116941 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt EP(-109 943 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118191 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118791 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119901 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119961 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119641 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaatt atttgattat aaattacttt cttcatatta gagttgtgaa 119941 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt 120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120421 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120981 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120591 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120891 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121191 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122391 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122901 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac WO 00/09525 PCT/US99/17~12 EPI-109 gq4 122461 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123921 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123981 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123541 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123891 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 129021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 129201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 129261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 124321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 129381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124941 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa 124501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 129621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 129791 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 124801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 129921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125041 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125391 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatctt aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125691 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125941 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126981 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126541 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct 126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127191 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127941 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127741 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128391 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401 ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128961 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128691 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129291 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttggcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 229421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129481 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129541 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130141 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130941 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130791 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc 130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131391 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt 131901 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131461 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131641 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131991 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132291 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132591 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132891 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133141 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct 133441 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactttct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 139101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 134281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 134341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134901 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 134461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 139581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 139701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 134881 attggacttc tttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135291 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacaqg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc 135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136141 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136441 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136791 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137091 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137341 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137901 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137461 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137641 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt 137941 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138241 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138421 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138541 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138891 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139141 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139491 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139741 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140041 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 140101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 190221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 190281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 140341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta 190401 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 190641 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 140761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 190821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 190881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 140991 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 191061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 191121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 141181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt 191241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 141421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aacagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 191591 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc (2) INFORMATION FOR SEQ ID N0:2695:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2695 1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 241 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 921 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag (2) INFORMATION FOR SEQ ID N0:2696:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2696 1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct 61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt 121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca 181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg 241 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag 301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat 361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct 421 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg 981 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa 541 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag 601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc 661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct 721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc 781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa 841 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact 901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg 961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt WO 00/09525 PCT/US99/177.12 1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa 1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac 1141 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca 1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa 1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca 1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct 1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc 1941 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg 1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat 1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa 1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat 1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca 1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc 1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata 1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga 1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt 1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg 2091 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta 2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt 2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag 2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa 2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct 2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag 2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat 2961 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga 2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc 2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa 2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat 2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg 2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca 2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg 2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta 2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta 3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt 3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga 3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac 3181 ttatc (2) INFORMATION FOR SEQ ID N0:2697:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2697 1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa 61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc 121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc 181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac 241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg 301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt 361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc 921 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat 981 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc 541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct 601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc 661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag 721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg 781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt 841 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta 901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc 961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat 1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa 1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat 1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat 1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt 1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt 1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc 1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga 1491 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgcg gcaggagaag 1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc 1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg 1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata 1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag 1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc 1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac 1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa 1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa 1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc 2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag 2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg 2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg 2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc 2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca 2341 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgtat ttctttgtaa 2901 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa 2961 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat 2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt 2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt 2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact 2?O1 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg 2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct 2821 ggg (2) INFORMATION FOR SEQ ID N0:2698:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2698 1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 281 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 241 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 921 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 981 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 541 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1141 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1682 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1741 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2091 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2221 tcttccaagc acagccactt ctgtqaacat ccctgacctg cttcctggcc gaaaatacat 2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2901 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2961 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2641 gccctctccc agggacctgc agtttgtgga agtgacaqac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2941 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3291 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3921 aaacaaagtg gtgacacca.t tgtctccacc aacaaacttg catctggagg caaaccctga 3981 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3541 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 9081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 9141 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 9381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4441 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 9921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 9981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5091 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5391 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5901 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5461 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5641 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761.ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac EPI-l09 952 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6421 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781 ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6841 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca (2) INFORMATION FOR SEQ ID N0:2699:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (8) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2699 1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 291 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 921 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag 1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct 61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt 121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca 181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg 291 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag 301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat 361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct 921 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg 481 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa 591 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag 601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc 661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct 721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc 781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa 891 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact 901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg 961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt 1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa 1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac 1191 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca 1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa 1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca 1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct 1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc 1441 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg 1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat 1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa 1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat 1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca 1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc 1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata 1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga 1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt 1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg 2041 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta 2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt 2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag 2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa 2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct 2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag 2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat 2961 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga 2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc 2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa 2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat 2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg 2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca 2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg 2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta 2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta 3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt 3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga 3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac 3181 ttatc 1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa 61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc 121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc 181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac 241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg 301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt 361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc 921 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat 481 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc 541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct 601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc 661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag 721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg 781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt 891 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta 901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc 961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat 1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa 1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat 1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat 1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt 1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt 1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc 1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga 1941 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgcg gcaggagaag 1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc 1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg 1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata 1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag 1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc 1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac 1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa 1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa 1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc 2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag 2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg 2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg 2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc 2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca 2391 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgcat ttctttgtaa 2901 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa 2961 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat 2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt 2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt 2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact 2701 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg 2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct 2821 ggg 1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 181 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 291 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 921 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 481 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 591 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1191 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1681 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1791 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2041 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2221 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat 2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2901 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2961 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2691 gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2991 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3241 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3421 aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3981 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3591 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4191 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 9201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 9261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 9381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 9941 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 9501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 9561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 9921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 9981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5041 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5341 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5401 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5961 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5691 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761 ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6921 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catqacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781.ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6891 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca (2) INFORMATION FOR SEQ ID N0:2700:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2700 1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg 61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg 121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc 181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg 241 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa 301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc 361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc 421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg 481 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg 591 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcqggcggg cggcgcgggt 601 ggcgccgagg ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt 661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc 721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata 781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc 841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg 901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct 1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact 1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg 1141 actcggacgt ctttgtgcc't tatggctacc tctaccccag aagccacccc ggcgacccgc 1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc 1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg 1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca 1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca 1991 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag 1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc 1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc 1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc 1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga 1791 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt 1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2041 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2341 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2401 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2461 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggaqttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa 2691 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga 2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc 2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a (2) INFORMATION FOR SEQ ID N0:2701:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2701 1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc 61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg 121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg 181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc 241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc 301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc 361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct 421 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg 981 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg 591 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc 601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc 661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga 721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct 781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc 891 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt 901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg 961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc 1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc 1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg 1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga 1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag (2) INFORMATION FOR SEQ ID N0:2702:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2702 1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt 121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg 181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata 241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac 301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac 361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc 421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc 481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc 541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca 601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat 661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag 721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc 781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc 841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc 901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac 961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg (2) INFORMATION FOR SEQ ID N0:2703:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2703 1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc 61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt 121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg 181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta 241 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc 301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg 361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga 421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct 981 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg 541 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact 601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact 661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg 721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg 781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga 841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg 901 ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag 961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg 1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca 1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt 1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga 1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc 1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt 1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga 1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa 1991 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg 1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc 1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac 1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg 1681 agcagtgaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID N0:2709:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2704 1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg 61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg 121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc 181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg 291 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa 301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc 361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc 421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg 981 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg 591 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt 601 ggcgccgagg ccgggggctq ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt 661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc 721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata 781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc 841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg 901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct 1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact 1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg 1141 actcggacgt ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc 1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc 1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg 1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca 1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca 1491 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag 1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc 1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc 1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc 1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga 1741 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt 1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2091 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2391 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2901 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2961 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggagttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa 2691 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga -2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc 2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a 1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc 61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg 121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg 181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc 241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc 301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc 361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct 921 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg 481 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg 541 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc 601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc 661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga 721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct 781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc 841 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt 901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg 961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc 1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc 1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg 1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga 1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag 1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt 121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg 181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata 241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac 301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac 361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc 421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc 481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc 541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca 601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat 661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag 721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc 781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc 841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc 901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac 961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg 1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc 61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt 121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg 181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta 291 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc 301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg 361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga 421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct 981 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg 591 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact 601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact 661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg 721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg 781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga 841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg 901.ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag 961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg 1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca 1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt 1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga 1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc 1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt 1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga 1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa WO 00/09525 PCT/US99/1??12 1941 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg 1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc 1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac 1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg 1681 agcagtgaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID N0:2705:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2705 1 cccccctcca agataatttt taaaaaacct tctcctttgc tcacctttgc ttcccagcct 61 tcccatcccc ccaccgaaag caaatcattc aacgaccccc gaccctccga cggcaggagc 121 cccccgacct cccaggcgga ccgccctccc tccccggggt tccgggcccg gcgagagggc 181 gcgagcacag ccgaggccat ggaggtgacg gcggaccagc cgcgctgggt gagccaccac 241 caccccgccg tgctcaacgg gcagcacccg gacacgcacc acccgggcct cagccactcc 301 tacatggacg cggcgcagta cccgctgccg gaggaggtgg atgtgctttt taacatcgac 36T ggtcaaggca accacgtccc gccctactac ggaaactcgg tcagggccac ggtgcagagg 921 taccctccga cccaccacgg gagccaggtg tgccgcccgc ctctgcttca tggatcccta 481 ccctggctgg acggcggcaa agccctgggc agccaccaca ccgcctcccc ctggaatctc 591 agccccttct ccaagacgtc catccaccac ggctccccgg ggcccctctc cgtctacccc 601 ccggcctcgt cctcctcctt gtcggggggc cacgccagcc cgcacctctt caccttcccg 661 cccaccccgc cgaaggacgt ctccccggac ccatcgctgt ccaccccagg ctcggccggc 721 tcggcccggc aggacgagaa agagtgcctc aagtaccagg tgcccctgcc cgacagcatg 781 aagctggagt cgtcccactc ccgtggcagc atgaccgccc tgggtggagc ctcctcgtcg 841 acccaccacc ccatcaccac ctacccgccc tacgtgcccg agtacagctc cggactcttc 901 ccccccagca gcctgctggg cggctccccc accggcttcg gatgcaagtc caggcccaag 961 gcccggtcca gcacagaagg cagggagtgt gtgaactgtg gggcaacctc gaccccactg 1021 tggcggcgag atggcacggg acactacctg tgcaacgcct gcgggctcta tcacaaaatg 1081 aacggacaga accggcccct cattaagccc aagcgaaggc tgtctgcagc caggagagca 1141 gggacgtcct gtgcgaactg tcagaccacc acaaccacac tctggaggag gaatgccaat 1201 ggggaccctg tctgcaatgc ctgtgggctc tactacaagc ttcacaatat taacagaccc 1261 ctgactatga agaaggaagg catccagacc agaaaccgaa aaatgtctag caaatccaaa 1321 aagtgcaaaa aagtgcatga ctcactggag gacttcccca agaacagctc gtttaacccg 1381 gccgccctct ccagacacat gtcctccctg agccacatct cgcccttcag ccactccagc 1941 cacatgctga ccacgcccac gccgatgcac ccgccatcca gcctgtcctt tggaccacac 1501 cacccctcca gcatggtcac cgccatgggt tagagccctg ctcgatgctc acagggcccc 1561 cagcgagagt ccctgcagtc cctttcgact tgcatttttg caggagcagt atcatgaagc 1621 ctaaacgcga tggatatatg tttttgaagg cagaaagcaa aattatgttt gccactttgc 1681 aaaggagctc actgtggtgt ctgtgttcca accactgaat ctggacccca tctgtgaata 1741 agccattctg actcatatcc cctatttaac agggtctcta gtgctgtgaa aaaaaaaatg 1801 ctgaacattg catataactt atattgtaag aaatactgta caatgacttt attgcatctg 1861 ggtagctgta aggcatgaag gatgccaaga agtttaagga atatgggaga aatggtgtgg 1921 aaattaagaa gaaactaggt ctgatattca aatggacaaa ctgccagttt tgtttccttt 1981 cactggccac agttgtttga tgcattaaaa gaaaataaaa aaaag (2) INFORMATION FOR SEQ ID N0:2706:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2706 1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg 61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct 121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg 181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga 241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc 301.tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg 361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact 421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg 481 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt 541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct 601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa 661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc 721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa (2) INFORMATION FOR SEQ ID N0:2707:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2707 1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct 121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac 181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc 291 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt 301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca 361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg 421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata 481 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc 591 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt 601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa 661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc 721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag 781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct 841 ggtqatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg 901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa 961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga 1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga 1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag 1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt 1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg 1261 gtggctcacg cctgtaatcc cag (2) INFORMATION FOR SEQ ID N0:2708 (i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2708 1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc 61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg 121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct 181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat 241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc 301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg 361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg 421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct 481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca 541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt 601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag 661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc 721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg 781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc 891 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt 901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag 961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc 1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg 1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga 1191 gctcctttat cagctgagcq gccatgggca gacctagcat tcaatggcca ggagtcacca 1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct 1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg 1321,gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc 1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct 1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag 1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca 1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac 1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa 1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca 1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg EPt-109 962 1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2901 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2691 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2991 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat (2) INFORMATION FOR SEQ ID N0:2709:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2709 1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg 61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct 121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg 181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga 241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc 301 tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg 361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact 421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg 981 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt 541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct 601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa 661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc 721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa 1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct 121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac 181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc 241 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt 301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca 361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg 421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata 981 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc 541 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt 601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa 661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc 721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag 781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct 841 ggtgatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg 901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa 961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga 1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga 1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag 1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt 1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg 1261 gtggctcacg cctgtaatcc cag 1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc 61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg 121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct 181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat 291 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc E?I-109 963 301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg 361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg 421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct 981 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca 541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt 601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag 661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc 721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg 781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc 841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt 901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag 961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc 1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg 1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga 1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca 1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct 1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg 1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc 1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct 1941 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag 1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca 1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac 1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa 1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca 1791 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg 1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2091 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2961 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2991 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat (2) INFORMATION FOR SEQ ID N0:2710:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2710 1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg 61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc 121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga 181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat 241 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact 301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct 361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg 421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct 981 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta 541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg 601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa 661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca 721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc 781 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc 841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag 901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa 961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc 1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta 1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga 1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat 1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc 1261 tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccctcaa gcagtcctcc 1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag 1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt 1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact 1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg 1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg 1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac 1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg 1741 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt 1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag 1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc 1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct 1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga 2091 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca 2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt 2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa 2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt 2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat 2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc 2401 agggagtgag ccataactgg cggctgctct tgcgccaatg (2) INFORMATION FOR SEQ ID N0:2711:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2711 1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag 61 accactatgg ccagccccca gctgatgccc ctggtqgtgg tcctgagcac tatctgcttg 121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac 181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc 291 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc 301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc 361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt 921 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt 981 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag 591 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc 601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa 661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctq 721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt 781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc 841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa 901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg 961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac 1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct 1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg 1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga 1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt 1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc 1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc 1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc 1491 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc 1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg 1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca 1621 ccatagaaga acagcagatg gcggtgatca gcag (2) INFORMATION FOR SEQ ID N0:2712:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2712 1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc 61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc 121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact 181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcg=ggg tgccgtcgtc 291 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc 301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc 361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc 421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt 981 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt 541 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac 601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac 661 tgccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg 721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg 781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc 891 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc 901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac 961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca 1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga 1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct 1191 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag 1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc 1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc 1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac 1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag 1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta 1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc 1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca 1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa 1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa 1791 as (2) INFORMATION FOR SEQ ID N0:2713:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2713 1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg 61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc 121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga 181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat 291 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact 301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct 361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg 421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct 981 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta 541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg 601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa 661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca 721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc 7B1 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc 841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag 901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa 961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc 1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta 1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga 1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat 1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc 126T tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccc~caa gcagtcctcc 1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag 1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt 1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact 1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg 1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg 1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac 1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg 1791 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt 1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag 1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc 1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct 1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga 2041 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca 2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt 2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa 2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt 2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat 2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc 2401 agggagtgag ccataactgg cggctgctct tgcgccaatg 1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag 61 accactatgg ccagccccca gctgatgccc ctggtggtgg tcctgagcac tatctgcttg 121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac 181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc 241 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc 301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc 361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt 421 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt 981 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag 541 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc 601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa 661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctg 721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt 781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc 841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa 901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg 961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac 1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct 1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg 1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga 1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt 1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc 1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc 1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc 1941 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc 1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg 1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca 1621 ccatagaaga acagcagatg gcggtgatca gcag 1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc 61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc 121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact 181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcgtggg tgccgtcgtc 241 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc 301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc 361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc 421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt 981 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt 591 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac 601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac 661 tqccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg 721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg 781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc 891 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc 901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac 961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca 1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga 1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct 1141 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag 1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc 1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc 1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac 1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag 1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta 1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc 1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca 1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa 1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa ~~~_ _~._._ ___._... ~",._,_.. .. .,~.._. __. .. . .. ~.~.""~.,~.~""~~ _ 1791 as (2) INFORMATION FOR SEQ ID N0:2719:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2714 1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg 61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc 121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg 181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag 291 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga 301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg 361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca 921 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag 981 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa 591 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg 601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg 661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga 721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta 781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt 841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag 901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag 961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga 1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac 1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata 1141 ctggttctca agaacttctt tcagagacaq gaatttctct ggatcctcgg aaaccagcct 1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata 1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt 1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg 1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa 1941 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt 1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc 1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa 1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat 1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct 1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata 1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa 1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga 1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc 1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag 2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat 2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag 2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa 2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg 2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca 2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt 2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact 2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca 2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta 2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat 2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg 2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa 2761 gtaaaagtct acctgtgttt ttttctaaaa aqgctgctca caagttctat ttcttgaaga 2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt 2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat 2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg 3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt 3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg 3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat 3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa 3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt 3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt 3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa 3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag 3981 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3591 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa (2) INFORMATION FOR SEQ iD N0:2715:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2715 1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg 61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc 121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg 181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc 241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc 301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg 361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc 421 tgctggccat ggagtactqc caaggaggag atctccggaa gtacctgaac cagtttgaga 481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc 591 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc 601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc 661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc 721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct 781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt 841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg 901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac 961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca 1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc 1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc 1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc 1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag 1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca 1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta 1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg 1941 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag 1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg 1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg 1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg 1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc 1741 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg 1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga 1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc 1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca 1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg 2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg 2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc 2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca 2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac 2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga 2391 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg 2401 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc 2961 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg 2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt 2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca 2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta 2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc 2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt 2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc 2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg 2941 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt 3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa (2) INFORMATION FOR SEQ ID N0:2716:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2716 1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc WO 00/09525 PC'T/US99/17712 121 gaggtcccat cagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg 181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc 241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct 301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat 361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga 921 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa 981 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg 541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg 601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga 661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct 721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc 781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca 841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg 901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga 961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca 1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga 1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga 1141 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc 1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc 1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga 1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca 1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga 1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga 1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc 1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat 1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc 1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct 1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg 1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc 1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta 1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa 1981 aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID N0:2717:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2717 1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg 61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc 121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg 181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag 241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga 301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg 361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca 421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag 481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa 541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg 601 ccaaagatgt tqatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg 661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga 721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta 781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt 841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag 901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag 961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga 1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac 1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata 1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct 1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata 1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt 1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg 1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa 1942 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt 1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc 1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa 1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat 1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct 1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata 1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa 1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga 1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc 1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag 2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat 2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag 2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa 2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg 2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca 2391 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt 2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact 2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca 2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta 2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat 2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg 2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa 2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga 2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt 2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat 2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg 3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt 3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg 3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat 3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa 3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt 3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt 3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa 3921 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag 3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa 1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg 61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc 121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg 181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc 241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc 301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg 361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc 421 tgctggccat ggagtactgc caaggaggag atctccggaa gtacctgaac cagtttgaga 481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc 541 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc 601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc 661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc 721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct 781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt 841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg 901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac 961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca 1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc 1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc 1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc 1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag 1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca 1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta 1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg 1941 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag 1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg 1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg 1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg 1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc 1791 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg 1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga 1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc 1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca 1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg 2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg 2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc 2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca 2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac 2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga 2391 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg 2901 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc 2461 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg 2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt 2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca 2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta 2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc 2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt 2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc 2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg 2991 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt 3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa 1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc 121 gaggtcccat cagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg 181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc 241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct 301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat 361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga 421 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa 981 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg 541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg 601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga 661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct 721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc 781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca 841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg 901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga 961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca 1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga 1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga 1191 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc 1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc 1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga 1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca 1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga 1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga 1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc 1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat 1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc 1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct 1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg 1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc 1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta 1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa 1981 aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID N0:2718:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear {xi)SEQUENCE DESCRIPTION: SEQ ID N0:2718 1 gaattcctct ggtcctcatc caggtgcgcg ggaagcaggt gcccaggaga gaggggataa 61 tgaagattcc atgctgatga tcccaaagat tgaacctgca gaccaagcgc aaagtagaaa 121 ctgaaagtac actgctggcg gatcctacgg aagttatgga aaaggcaaag cgcagagcca 181~cgccgtagtg tgtgccgccc cccttgggat ggatgaaact gcagtcgcgg cgtgggtaag 241 aggaaccagc tgcagagatc accctgccca acacagactc ggcaactccg cggaagacca 301 gggtcctggg agtgactatg ggcggtgaga gcttgctcct gctccagttg cggtcatcat 361 gactacgccc gcctcccgca gaccatgttc catgtttctt ttaggtatat ctttggactt 421 cctcccctga tccttgttct gttgccagta gcatcatctg attgtgatat tgaaggtaaa 481 gatggcaaac aatatgagag tgttctaatg gtcagcatcg atcaattatt ggacagcatg 591 aaagaaattg gtagcaattg cctgaataat gaatttaact tttttaaaag acatatctgt 601 gatgctaata aggaaggtat gtttttattc cgtgctgctc gcaagttgag gcaatttctt 661 aaaatgaata gcactggtga ttttgatctc cacttattaa aagtttcaga aggcacaaca EPI-109 g7z 721 atactgttga actgcactgg ccaggttaaa ggaagaaaac cagctgccct gggtgaagcc 781 caaccaacaa agagtttgga agaaaataaa tctttaaagg aacagaaaaa actgaatgac 841 ttgtgtttcc taaagagact attacaagag ataaaaactt gttggaataa aattttgatg 901 ggcactaaag aacactgaaa aatatggagt ggcaatatag aaacacgaac tttagctgca 961 tcctccaaga atctatctgc ttatgcagtt tttcagagtg gaatgcttcc tagaagttac 1021 tgaatgcacc atggtcaaaa cggattaggg catttgagaa atgcatattg tattactaga 1081 agatgaatac aaacaatgga aactgaatgc tccagtcaac aaactatttc ttatatatgt 1141 gaacatttat caatcagtat aattctgtac tgatttttgt aagacaatcc atgtaaggta 1201 tcagttgcaa taatacttct caaacctgtt taaatatttc aagacattaa atctatgaag 1261 tatataatgg tttcaaagat tcaaaattga cattgcttta ctgtcaaaat aattttatgg 1321 ctcactatga atctattata ctgtattaag agtgaaaatt gtcttcttct gtgctggaga 1381 tgttttagag ttaacaatga tatatggata atgccggtga gaataagaga gtcataaacc 1441 ttaagtaagc aacagcataa caaggtccaa gatacctaaa agagatttca agagatttaa 1501 ttaatcatga atgtgtaaca cagtgccttc aataaatggt atagcaaatg ttttgacatg 1561 aaaaaaggac aatttcaaaa aaataaaat (2) INFORMATION FOR SEQ ID N0:2719:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2719 1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaat't catggtggtg ttagaaatca gaagagaggc tacctttgtg 291 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301 gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 481 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 591 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag 961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgactgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1791 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2901.aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2991 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3421 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3981 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3541 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3841 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 9021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 4081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 9261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 4321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 4381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4441 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 4501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 9621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 9681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 4791 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801 taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 4861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 9921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 4981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5391 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa 5461 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5991 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6241 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6921 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6981 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6591 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6841 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7191 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7491 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7791 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcaccttt cacatacatg tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8401 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag 8961 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8691 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301 acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9421 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9481 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcas 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9841 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt 9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt 10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10991 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11091 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11391 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11461 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11691 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11941 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg EPt-109 975 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12921 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12981 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12591 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12891 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13141 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13441 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14041 aagtccgtcc ccttcttaat caatgcagag gctacccact ccacattacc ttctcttcaa 19101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 14161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 14221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 19281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 19341 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 14401 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat 19961 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 19521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 14581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 14641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 14701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 14761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 19881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 19941 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15291 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15981 tcattccaga caccagccca acttgaactg tgccccaaaa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16441 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct WO 00/09525 PCT/US99/i77~2 16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16791 aatatcaccc cttaccacad aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17091 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17691 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18241 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361 atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18481 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18591 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18841 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19941 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20091 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20341 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20401 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20961 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagct ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20991 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag WO 00/09525 PCT/US99l17712 21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22491 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22741 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23391 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23401 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23691 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23941 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 29181 cagaggtaag gctactcact gtttasaccc ctttagtgat atcccaaaag acctcaagat 29241 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 24361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 24421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 29481 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 29541 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 29781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 29841 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 29901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25491 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa 25501 tctgccatct catcctacct gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26341 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26461 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27241 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27591 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29091 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29901 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29461 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29691 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29941 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30241 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30481 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30591 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaat gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30841 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31191 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31991 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31791 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32341 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat 32961 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33291 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33421 actgacgcct ggatttgaa.t cctagccctg ccacttgata accatgtgcc tttaaacaag 33981 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33591 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 39141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 34201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 34321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 39491 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 39561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 39861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 34981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcasttcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35341 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35961 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35942 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36291 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacct caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36981 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36541 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36891 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt 36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37491 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37791 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38041 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38391 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38901 ttgtagggac tcagaaaata cctgttgtat gaaaagagca ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38941 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat EPI-109 98t 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39291 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39921 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 40021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081 tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 40321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 90381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 40491 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 90501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 90621 tcctcctcct tcttttccac caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40791 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tgqacgtcct tgttagtggc 90861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41091 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact 41461 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 91701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 91761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 41881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41941 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 92001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 42121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 42291 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 92301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 92421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 92481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 42541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 42601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 42661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 42721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 92781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 42841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 42901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 93021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 93081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 93141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 93201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 43381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43441 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa WO 00/09525 . PCT/US99/17712 93501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 43561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 43741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 43801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 93861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 93921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 43981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 44041 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 94101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 99161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 99221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 94391 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 94901 aatggggaaa aacgtggagc cagggaqact tgtgaaagtg ccagtgctcc cactataccc 49461 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 49581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 49641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 49701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 49761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 44821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 94881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 49941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 45001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 45061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 95121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 45181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 45291 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 45301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 45361 attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 45421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 45481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 45541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg.cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 95721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 45781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 45841 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag 45961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 96021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 46201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 96381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 46501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 96561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 46621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46741 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 96921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 96981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 97041 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 97391 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 47401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 97961 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 97581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 97641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 97701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 97821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 47941 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc WO 00/09525 PC'f/US99/17712 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 98241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 98361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 98421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48481 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48591 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 48601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 98661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 98721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 98781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 98961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 99021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 99081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 99141 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 99201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 49261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 49381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 49941 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 49501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 99561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 49681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 99741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 99801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 99861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 49921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 49981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggg gcagttgata 50341 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt 50461 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50991 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51241 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51591 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51841 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52191 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52991 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat 52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa 52741 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53341 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53901 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53961 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 54001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 54061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 59181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 59291 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 59301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 59361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga 54591 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 59661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 59721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 54781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 59841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga 54961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56091 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56391 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56901 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa EPl-109 985 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57291 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57421 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57981 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57591 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58191 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58741 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59092 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59391 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59901 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc 59461 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca cascaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59691 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt gttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60921 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61941 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt EPI-l09 9g6 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62901 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62961 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361 gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63921 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63541 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63841 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 64021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081 attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 69191 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 64381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64441 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 69501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 69561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 69621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 69791 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 64801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 69861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 64981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65041 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65391 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66241 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66421 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66981 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66591 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66891 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67191 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 6?441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67741 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68041 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68391 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt 68961 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68941 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69421 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69541 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70191 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag 70991 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga EPI-109 9gg 70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70791 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71041 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71341 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71901 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71641 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga 71821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72241 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72921 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72481 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72591 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73941 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 79281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74391 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74901'tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 74961 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 74521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 79581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 79691 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 79701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 79881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 79941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga EPl-109 9g9 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggagagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75241 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75421 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76941 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctag,~ atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77341 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca 77961 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78981 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78591 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78891 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901'ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaag 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79791 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80341 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80401 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80961 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80991 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81981 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82491 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83091 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgt.g aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83901 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa 83961 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83941 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc 84001 accatgccca gctaattt~g tatttttagt agagacgagg tttctccacg ttggccaggc 89061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag 84181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa 84291 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 89361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 89921 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 89541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 89601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt 89721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg 84891 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 89901 tgattgcaga ctagacatt.t tgaattaaac attatagaga ttctggattc tcgagagagt 89961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85141 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtqccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85491 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgc ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85741 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt 85861 tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatgaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86391 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86901 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc 86961 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86991 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgccac tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87921 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87481 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87591 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87891 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901'gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88191 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88941 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga bP1-109 992 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89901 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89691 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90291 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361 gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90421 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90981 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90591 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90841 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91191 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91941 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92091 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92391 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401'caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92961 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92691 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92991 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93921 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93841 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 99081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 99201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 94321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 99381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94491 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 99501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 99621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 94681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 99741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 99801 cctttgacct agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 94861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 94921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 94981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95091 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95341 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95901 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca 95461 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95641 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95991 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc 96291 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96981 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96591 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97191 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac EPI-109 ~4 97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg 97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct 97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca 97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag 97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc 97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat 97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa 97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt 97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag 98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta 98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat 98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc 98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat 98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat 98391 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga 98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac 98961 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca 98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat 98581 aggacacata aaatcctaga tctcacagaa ttgacattcc agagagggaa aggtagacaa 98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa 98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca 98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc 98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa 98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag 98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca 99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta 99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat 99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct 99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg 99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta 99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg 99361 ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt 99421 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt 99481 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag 99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct 99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc 99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc 99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata 99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa 99841 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta 99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca 99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100191 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100491 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101041 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt 101391 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 10140I gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101961 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101691 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101991 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca EPl-109 995 102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaagaa acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102241 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102421 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102981 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102591 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103141 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacat.caaa taaggaaata 103991 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861 taataaataa aaataaaata tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 109041 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 109161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 104281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 104341 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104901 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 109521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 109581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 109641 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 109701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 109821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104941 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105241 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105921 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105591 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105841 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aagggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106441 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106741 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107091 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107901 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107961 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107941 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108421 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108591 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108841 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109941 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110091 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110341 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110991 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111291 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111421 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111981 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112191 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113091 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113901 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113641 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 114001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 119061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 114121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 114181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114291 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 119301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 119361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 114421 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 119481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 119541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 119601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa 114661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 114721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 114781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 119841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115191 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct ccctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115491 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa 115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggc~t tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116341 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116401 aatggctctt gtgagcacca aatcattgtg agaaggaaaa cccatctctt acagccccct 116961 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116641 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116991 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118141 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118741 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119401 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119461 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119691 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaat.t atttgattat aaattacttt cttcatatta gagttgtgaa 119991 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt 120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120921 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120481 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120591 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120841 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121141 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122391 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122401 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac 122961 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123421 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123981 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123591 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123841 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 129021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 124201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 124261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 129321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 124381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124991 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa EPI-i 09 129501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 124621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 129741 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 129801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 124921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125091 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125391 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatett aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125641 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125991 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126481 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126591 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct 126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127191 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127491 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127791 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128391 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401' ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128961 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128641 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129241 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttgqcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 129421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129981 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129591 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130191 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130941 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130741 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc 130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131341 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt 131901 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131961 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131691 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131941 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132291 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132591 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132891 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133191 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct 133491 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactt:ct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 139101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 139281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 139341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134901 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 139461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 134581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 139701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 139881 attggacttc ttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135241 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacagg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc 135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136191 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136941 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136791 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137091 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137391 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137401 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137961 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137691 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt 137991 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138291 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138921 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138591 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138891 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139191 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139491 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt.tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139791 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140091 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 190101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 140221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 190281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 190341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta 140901 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 190691 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 190761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 140821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 140881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 190991 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 191061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 141121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 191181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt 141241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 191421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aacagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 141591 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc (2) INFORMATION FOR SEQ ID N0:2720:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2720 1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct 61 caagcaatcc tcctgccttg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 291 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 421 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg (2) INFORMATION FOR 5EQ ID N0:2721:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2721 1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg 61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg 121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag 181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct 291 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc 301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc 361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac 421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag 481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat 541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg 601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc 661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag 721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga 781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc 841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac 901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc 961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat 1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag 1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc 1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt 1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat 1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg 1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg 1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac 1941 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc 1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg 1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa 1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg 1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt 1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag 1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg 1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag 1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta 1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc 2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact 2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag 2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa 2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc 2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat 2391 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc 2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt 2961 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg 2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag 2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg 2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca 2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg 2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc 2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc 2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat 2991 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc 3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg 3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg 3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg 3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg 3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac 3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc 3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg 3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg 3981 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc 3591 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc 3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca 3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca 3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg 3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg 3891 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg 3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 9141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 9321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4991 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt 9501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt 9681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:2722:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2722 1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg 61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg 121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca 181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact 241 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca 301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct 361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga 421 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg 481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct 541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct 601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc 661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga 721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa 781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta 841 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat 901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc 961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt 1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag 1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca 1141 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg 1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt 1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt 1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca 1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag 1441 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac 1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt 1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc 1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct 1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag 1741 ggtaactttt gggtctgtca taaatagagg gccc (2) INFORMATION FOR SEQ ID N0:2723:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2723 1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct EPI-l09 1006 61 caagcaatcc tcctgcc~tg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 241 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 921 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg 1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg 61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg 121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag 181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct 241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc 301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc 361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac 421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag 481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat 591 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg 601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc 661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag 721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga 781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc 841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac 901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc 961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat 1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag 1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc 1191 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt 1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat 1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg 1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg 1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac 1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc 1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg 1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa 1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg 1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt 1791 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag 1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg 1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag 1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta 1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc 2091 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact 2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag 2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa 2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc 2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat 2391 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc 2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt 2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg 2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag 2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg 2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca 2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg 2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc 2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc 2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat 2991 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc 3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg 3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg 3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg 3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg 3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac 3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc 3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg 3921 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg 3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc 3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc WO 00/09525 PCTlUS99/17712 3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca 3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca 3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg 3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg 3891 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg 3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 9021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 9081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 9261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 9381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4491 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt 4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 9561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt 9681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg 61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg 121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca 181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact 291 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca 301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct 361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga 921 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg 481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct 541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct 601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc 661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga 721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa 781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta B41 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat 901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc 961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt 1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag 1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca 1191 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg 1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt 1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt 1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca 1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag 1991 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac 1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt 1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc 1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct 1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag 1791 ggtaactttt gggtctgtca taaatagagg gccc (2) INFORMATION FOR SEQ ID N0:2729:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2724 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa 61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag 121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct 181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta 241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg 301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa 361 gaaagtgcag gggacccgcc gtcggggtqg gggcggcgct gcccagcctc tgtcccactt 921 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg (2) INFORMATION FOR SEQ ID N0:2725:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2725 i atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc 61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc 121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg 181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc 241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc 301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc 361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg 421 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg 981 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 591 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 841 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac 1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg 1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca 1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag 1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg 1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc 1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa 1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg 1491 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc 1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga 1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat (2) INFORMATION FOR SEQ ID N0:2726:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2726 1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac 61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc 121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag 181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg 241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg 301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc (2) INFORMATION FOR SEQ ID N0:2727:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2727 1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181. ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc (2) INFORMATION FOR SEQ ID N0:2728:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/177i2 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2728 1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg (2) INFORMATION FOR SEQ ID N0:2729:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2729 1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121 cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 241 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 981 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctqaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat (2) INFORMATION FOR SEQ ID N0:2730:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2730 1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca 361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 921 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga 981 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 591 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc 1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc 1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt 1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac 1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc 1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact 1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc 1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc 1441 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc 1501. tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:2731:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2731 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa EPI-109 tOlO
61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag 121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct 181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta 241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg 301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa 361 gaaagtgcag gggacccgcc gtcggggtgg gggcggcgct gcccagcctc tgtcccactt 921 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg 1 atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc 61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc 121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg 181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc 241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc 301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc 361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg 921 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg 481 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 541 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 891 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac 1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg 1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca 1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag 1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg 1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc 1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa 1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg 1441 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc 1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga 1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat 1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac 61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc 121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag 181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg 241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg 301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc 1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181 ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc 1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg 1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121'cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 291 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 481 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctgaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat 1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca 361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 421 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga 981 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 591 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc 1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc 1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt 1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac 1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc 1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact 1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc 1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc 1491 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc 1501 tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:2732:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2732 1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagagqc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 921 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 981 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 891 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1191 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt (2) INFORMATION FOR 5EQ ID'N0:2733:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2733 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt 61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg 121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat 181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat 241 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca 301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg 361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc 421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca 981 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt 541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc 601 cacataaaag ttgacttgga aaaagacttc tgctgctaaa caaaagttga aactgccttg 661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga 721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat 781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac 841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa 901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc 961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc 1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag 1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga 1141 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag 1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc 1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta 1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta 1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa 1941 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct 1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt 1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc 1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg 1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact 1791 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta 1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt 1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc 1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca 1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc 2041 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca 2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt 2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat 2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt 2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc 2341 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct 2901 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag 2961 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc 2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag 2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag 2691 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg 2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga 2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa 2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg 2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata 2991 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat 3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta 3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc 3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc (2) INFORMATION FOR SEQ ID N0:2734:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D1 TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2739 1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg 61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat 121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag 181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga 241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg 301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa 361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt 921 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac 481 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt EPI-109 . 1013 541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 891 aagaaaaaaa aaaaa (2) INFORMATION FOR SEQ ID N0:2735:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (8) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2735 1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc 61 ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac 121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag 181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg 241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg 301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg 361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt 921 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta 981 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat 591 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca 601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa (2) INFORMATION FOR SEQ ID N0:2736:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2736 1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatgcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 241 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 421 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 591 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:2737:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2737 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt 61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg 121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat 181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat 291 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca 301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg 361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc 421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca 481 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt 541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc EPl-109 1014 601 cacataaaag ttgactt,:ga aaaagacttc tgctgctaaa caaaagttga aactgccttg 661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga 721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat 781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac 841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa 901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc 961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc 1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag 1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga 1191 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag 1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc 1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta 1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta 1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa 1441 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct 1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt 1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc 1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg 1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact 1741 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta 1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt 1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc 1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca 1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc 2091 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca 2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt 2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat 2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt 2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc 2391 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct 2401 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag 2961 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc 2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag 2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag 2641 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg 2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga 2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa 2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg 2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata 2941 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat 3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta 3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc 3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc 1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg 61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat 121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag 181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga 241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg 301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa 361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt 921 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac 981 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt 541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 841 aagaaaaaaa aaaaa 1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc 6l ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac 121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag 181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg 241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg 301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg 361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt 421 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta 981 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat 541 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca 601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa 1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatqcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 291 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 921 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 591 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:273B:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2738 1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca 61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg 121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc 181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa 291 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc 301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct 361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa 421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc 981 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt 541 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc 601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag 661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg 721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca 781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga 891 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga 901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga 961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt 1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc 1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca 1191 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc 1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc 1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc 1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa 1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt 1491 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca 1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac 1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga 1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc 1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc 1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca 1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac 1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc 1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt 1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa 2091 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat 2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa 2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc 2221 taactccatg ttcataagaa aaaaaaaa (2) INFORMATION FOR SEQ ID N0:2739:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2739 1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 181 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga 421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg 981 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga (2) INFORMATION FOR SEQ ID N0:2740:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2790 1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg 61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat 121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat 241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat 361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact 921 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 591 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg 1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca 1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga 1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca 1491 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac 1501 actactaaat gtttgtcttt aaaggcagct gg (2) INFORMATION FOR SEQ ID N0:2741:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2791 1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 181.ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 591 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat 601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt 781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 891 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1941 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg (2) INFORMATION FOR SEQ ID N0:2792:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2792 1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 241 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 981 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt 541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1441 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1741 ctt (2) INFORMATION FOR SEQ ID N0:2793:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2743 1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 241 attgaggtaa gagacagatt ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag 361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat 921 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat 481 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac 541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg 601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag 661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa 721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc 781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt 891 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat 901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat 961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac 1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg 1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact 1141 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg 1201 ggtgagaga (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2799 1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca 61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg 121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc 181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa 241 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc 301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct 361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa 421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc 481 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt 591 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc 601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag 661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg 721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca 781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga 891 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga 901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga 961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt 1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc 1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca 1141 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc 1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc 1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc 1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa 1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt 1941 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca 1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac 1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga 1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc 1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc 1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca 1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac 1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc 1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt 1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa 2091 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat 2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa 2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc 2221 taactccatg ttcataagaa aaaaaaaa 1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 1B1 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga 421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg EPI-109 Iplg 481 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga 1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg 61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat 121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat 241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat 361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact 421 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 591 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg 1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca 1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga 1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca 1441 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac 1501 actactaaat gtttgtcttt aaaggcagct gg 1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 181 ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 291 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 921 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 541 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat 601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt 781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 841 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1491 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg 1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 291 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 981 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt 541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1991 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1741 ctt 1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 291 attgaggtaa gagacagatt ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag 361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat 421 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat 981 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac 541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg 601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag 661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa 721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc 781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt 891 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat 901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat 961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac 1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg 1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact 1191 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg 1201 ggtgagaga (2) INFORMATION FOR SEQ ID N0:2745:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2795 1 aaggacacgg gcagcagaca gtggtcagtc ctttcttggc tctgctgaca ctcgagccca 61 cattccgtca cctgctcaga atcatgcagg tctccactgc tgcccttgct gtcctcctct 121 gcaccatggc tctctgcaac cagttctctg catcacttgc tgctgacacg ccgaccgcct 181 gctgcttcag ctacacctcc cggcagattc cacagaattt catagctgac tactttgaga 241 cgagcagcca gtgctccaag cccggtgtca tcttcctaac caagcgaagc cggcaggtct 301 gtgctgaccc cagtgaggag tgggtccaga aatatgtcag cgacctagag ctgagtgcct 361 gaggggtcca gaagcttcga ggcccagcga cctcggtggg ccagtgggga ggagcaggag 421 cctgagcctt gggaaacatg cgtgtgacct ccacagctac ctcttctatg gactggttgt 981 tgccaaacag ccacactgtg qgactcttct taacttaaat tttaatttat ttatactatt 591 tagtttttgt aatttatttt cgatttcaca gtgtgtttgt gattgtttgc tctgagagtt 601 cccctgtccc ctcccccttc cctcacaccg cgtctggtga caaccgagtg gctgtcatca 661 gcctgtgtag gcagtcatgg caccaaagcc accagactga caaatgtgta tcggatgctt 721 ttgttcaggg ctgtgatcgg cctggggaaa taataaagca cgctctttta aaaggt (2) INFORMATION FOR SEQ ID N0:2746:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single EPI-109 ~O~I
(D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2796 1 acagccttga ccttatgtca tgggttcaac ttggacactg aaaacgcaat gaccttccaa 61 gagaacgcaa ggggcttcgg gcagagcgtg gtccagcttc agggatccag ggtggtggtt . 121 ggagcccccc aggagatagt ggctgccaac caaaggggca gcctctacca gtgcgactac 181 agcacaggct catgcgagcc catccgcctg caggtccccg tggaggccgt gaacatgtcc 291 ctgggcctgt ccctggcagc caccaccagc ccccctcagc tgctggcctg tggtcccacc 301 gtgcaccaga cttgcagtga gaacacgtat gtgaaagggc tctgcttcct gtttggatcc 361 aacctacggc agcagcccca gaagttccca gaggccctcc gagggtgtcc tcaagaggat 921 agtgacattg ccttcttgat tgatggctct ggtagcatca tcccacatga ctttcggcgg 981 atgaaggagt ttgtctcaac tgtgatggag caattaaaaa agtccaaaac cttgttctct 541 ttgatgcagt actctgaaga attccggatt cactttacct tcaaagagtt ccagaacaac 601 cctaacccaa gatcactggt gaagccaata acgcagctgc ttgggcggac acacacggcc 661 acgggcatcc gcaaagtggt acgagagctg tttaacatca ccaacggagc ccgaaagaat 721 gcctttaaga tcctagttgt catcacggat ggagaaaagt ttggcgatcc cttgggatat 781 gaggatgtca tccctgaggc agacagagag ggagtcattc gctacgtcat tggggtggga 891 gatgccttcc gcagtgagaa atcccgccaa gagcttaata ccatcgcatc caagccgcct 901 cgtgatcacg tgttccaggt gaataacttt gaggctctga agaccattca gaaccagctt 961 cgggagaaga tctttgcgat cgagggtact cagacaggaa gtagcagctc ctttgagcat 1021 gagatgtctc aggaaggctt cagcgctgcc atcacctcta atggcccctt gctgagcact 1081 gtggggagct atgactgggc tggtggagtc tttctatata catcaaagga gaaaagcacc 1191 ttcatcaaca tgaccagagt ggattcagac atgaatgatg cttacttggg ttatgctgcc 1201 gccatcatct tacggaaccg ggtgcaaagc ctggttctgg gggcacctcg atatcagcac 1261 atcggcctgg tagcgatgtt caggcagaac actggcatgt gggagtccaa cgctaatgtc 1321 aagggcaccc agatcggcgc ctacttcggg gcctccctct gctccgtgga cgtggacagc 1381 aacggcagca ccgacctggt cctcatcggg gccccccatt actacgagca gacccgaggg 1991 ggccaggtgt ccgtgtgccc cttgcccagg gggcagaggg ctcggtggca gtgtgatqct 1501 gttctctacg gggagcaggg ccaaccctgg ggccgctttg gggcagccct aacagtgctg 1561 ggggacgtaa atggggacaa gctgacggac gtggccattg gggccccagg agaggaggac 1621 aaccggggtg ctgtttacct gtttcacgga acctcaggat ctggcatcag cccctcccat 1681 agccagcgga tagcaggctc caagctctct cccaggctcc agtattttgg tcagtcactg 1741 agtgggggcc aggacctcac aatggatgga ctggtagacc tgactgtagg agcccagggg 1801 cacgtgctgc tgctcaggtc ccagccagta ctgagagtca aggcaatcat ggagttcaat 1861 cccagggaag tggcaaggaa tgtatttgag tgtaatgatc aggtggtgaa aggcaaggaa 1921 gccggagagg tcagagtctg cctccatgtc cagaagagca cacgggatcg gctaagagaa 1981 ggacagatcc agagtgttgt gacttatgac ctggctctgg actccggccg cccacattcc 2041 cgcgccgtct tcaatgagac aaagaacagc acacgcagac agacacaggt cttggggctg 2101 acccagactt gtgagaccct gaaactacag ttgccgaatt gcatcgagga cccagtgagc 2161 cccattgtgc tgcgcctgaa cttctctctg gtgggaacgc cattgtctgc tttcgggaac 2221 ctccggccag tgctggcgga ggatgctcag agactcttca cagccttgtt tccctttgag 2281 aagaattgtg gcaatgacaa catctgccag gatgacctca gcatcacctt cagtttcatg 2341 agcctggact gcctcgtggt gggtgggccc cgggagttca acgtgacagt gactgtgaga 2401 aatgatggtg aggactccta caggacacag gtcaccttct tcttcccgct tgacctgtcc 2461 taccggaagg tgtccacgct ccagaaccag cgctcacagc gatcctggcg cctggcctgt 2521 gagtctgcct cctccaccga agtgtctggg gccttgaaga gcaccagctg cagcataaac 2581 caccccatct tcccggaaaa ctcagaggtc acctttaata tcacgtttga tgtagactct 2641 aaggcttccc ttggaaacaa actgctcctc aaggccaatg tgaccagtga gaacaacatg 2701 cccagaacca acaaaaccga attccaactg gagctgccgg tgaaatatgc tgtctacatg 2761 gtggtcacca gccatggggt ctccactaaa tatctcaact tcacggcctc agagaatacc 2821 agtcgggtca tgcagcatca atatcaggtc agcaacctgg ggcagaggag cctccccatc 2881 agcctggtgt tcttggtgcc cgtccggctg aaccagactg tcatatggga ccgcccccag 2941 gtcaccttct ccgagaacct ctcgagtacg tgccacacca aggagcgctt gccctctcac 3001 tccgactttc tggctgagct tcggaaggcc cccgtggtga actgctccat cgctgtctgc 3061 cagagaatcc agtgtgacat cccgttcttt ggcatccagg aagaattcaa tgctaccctc 3121 aaaggcaacc tctcgtttga ctggtacatc aagacctcgc ataaccacct cctgatcgtg 3181 agcacagctg agatcttgtt taacgattcc gtgttcaccc tgctgccggg acagggggcg 3241 tttgtgaggt cccagacgga gaccaaagtg gagccgttcg aggtccccaa ccccctgccg 3301 ctcatcgtgg gcagctctgt cgggggactg ctgctcctgg ccctcatcac cgccgcgctg 3361 tacaagctcg gcttcttcaa gcggcaatac aaggacatga tgagtgaagg gggtcccccg 3921 ggggccgaac cccagtagcg gctccttccc gacagagctg cctctcggtg gccagcagga 3481 ctctgcccag accacacgta gcccccaggc tgctggacac gtcggacagc gaagtatccc 3591 cgacaggacg ggcttgggct tccatttgtg tgtgtgcaag tgtgtatgtg cgtgtgtgcg 3601 agtgtgtgca agtgtctgtg tgcaagtgtg tgcacgtgtc ggtgtgcgtg catgtgcact 3661 cgcacgccca tgtgtgagtg tgtgcaagta tgtgagtgtg tccaagtgtg tgtgcgtgtg 3721 tccatgtgtg tgcaagtgtg tgcatgtgtg cgagtgtgtg catgtgtgtg ctcaggggcg 3781 tgtggctcac gtgtgtgact cagatgtctc tggcgtgtgg gtaggtgacg gccagcgtag 3841 cctctccggc agaagggaac tgcctgggct cccttgtgcg tgggtgaagc cgctgctggg 3901 ttttcctccg ggagagggga cggtcaatcc tgtgggtgaa gacagaggga aacacagcag 3961 cttctctcca ctgaaagaag tgggacttcc cgtcgcctgc agcctgcggc ctgctggagc 9021 ctgcgcagct tggatggaga ctccatgaga agccgtgggt ggaaccagga gcctcctcca 4081 caccagcgct gatgcccaat aaagatgccc actgaggaat gatg (2) INFORMATION FOR SEQ ID N0:2747:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2797 1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac 61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc 121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg 181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca 241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga 301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa 361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta 921 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg 981 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc 541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc 601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc 661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt 721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac 781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa 891 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc 901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc 961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc 1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga 1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct 1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc 1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc 1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc 1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag 1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc 1491 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga 1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg 1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat 1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac 1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa 1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga 1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg 1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat 1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag 1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc 2091 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac 2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa 2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg 2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga 2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta 2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc 2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc 2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca 2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca 2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc 2691 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga 2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc 2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca 2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt 2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga 2991 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa (2) INFORMATION FOR SEQ ID N0:2798:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2798 EPl-109 1023 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 591 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1941 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1791 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2091 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2391 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2961 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3291 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid WO 00/09525 PC'TNS99/17712 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2749 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 291 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 981 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 591 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 891 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2391 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2691 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt 3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag 3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga 3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt 3361. gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc 3921 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc 3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt 3591 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt 3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt 3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt 3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa (2) INFORMATION FOR SEQ ID N0:2750:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2750 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 891 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1941 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1791 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2091 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301~acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa aaattagcca 3921 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3591 cggcagagca agactccgtc tcgggaaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID N0:2751:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid -(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2751 1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc ' 61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc 121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca 181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg 291 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg 301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg 361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg 421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc 9B1 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc 541 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc 601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc 661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc 721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag 781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac B41 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac 901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc 961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga 1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc 1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc 1141 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg 1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg 1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt 1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg 1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag 1441 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct gctgcgcccg 1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag 1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga 1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa 1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc 1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc 1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc 1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt 1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg 1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata 2091 accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac 2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat 2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca 2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc 2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc 2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc 2901 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc 2961 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa 2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc 2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca (2) INFORMATION FOR SEQ ID N0:2752:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2752 1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac 61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc 121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg 181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca 291 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga 301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa 361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta 421 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg aP~-io9 ~oz~
981 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc 591 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc 601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc 661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt 721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac 781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa B41 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc 901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc 961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc 1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga 1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct 1191 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc 1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc 1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc 1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag 1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc 1941 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga 1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg 1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat 1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac 1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa 1791 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga 1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg 1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat 1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag 1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc 2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac 2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa 2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg 2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga 2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta 2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc 2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc 2961 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca 2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca 2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc 2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga 2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc 2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca 2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt 2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga 2941 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 591 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1791 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3241 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcasac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaadc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2091 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2901 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2961 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt 3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag 3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga 3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt 3361 gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc 3421 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc 3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt 3541 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt 3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt 3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt 3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 921 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 981 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 891 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1191 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1491 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2961 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2991 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301 acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa.aaattagcca 3421 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3591 cggcagagca agactccgt'c tcgggaaaaa aaaaaaaaaa aaa 1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc 61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc 121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca 181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg 241 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg 301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg 361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg 421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc 481 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc 591 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc 601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc 661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc 721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag 781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac 841 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac 901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc 961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga 1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc 1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc 1191 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg 1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg 1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt 1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg 1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag 1941 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct. gctgcgcccg 1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag 1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga 1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa 1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc 1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc 1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc 1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt 1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg 1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata 2091. accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac 2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat 2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca 2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc 2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc 2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc 2901 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc 2461 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa 2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc 2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca (2) INFORMATION FOR SEQ ID N0:2753:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2753 1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcq 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c (2) INFORMATION FOR SEQ ID N0:2754:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2754 1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc 61 cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac 121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc 181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg 241 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat 301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt 361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg 421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg 481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc 591 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc 601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct 661 cttctccgac gactacgggg gcaagaactg caagaagccg gccgagtacg gctacgtgag 721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca 781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc 891 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc 901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag 961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc 1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag 1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa 1191 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca 1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc 1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc 1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac 1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca 1491 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat 1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa 1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag 1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg 1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct 1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt 1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga 1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg (2) INFORMATION FOR SEQ ID N0:2755:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2755 1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcg 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c 1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc 6I cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac 121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc 181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg 291 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat 301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt 361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg 421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg 481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc 541 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc 601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct 661 cttctccgac gactacggg.g gcaagaactg caagaagccg gccgagtacg gctacgtgag 721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca 781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc 841 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc 901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag 961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc 1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag 1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa 1141 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca 1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc 1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc 1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac 1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca 1441 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat 1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa 1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag 1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg 1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct 1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt 1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga 1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg (2) INFORMATION FOR SEQ ID N0:2756:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2756 1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg 61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc 121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc 181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca 241 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg 301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg 361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag 421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa 981 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca 541 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg 601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa 661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg 721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct 781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc 841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc 901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg 961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca 1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg 1O81~tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc 1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca 1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt 1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca 1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt 1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc 1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa 1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag 1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc 1;P1-109 1033 1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca 1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttacagag 1741 aaaaagaggg caaaccctt~ tatcaaatga cctcaaatgc cacccaggca ttttggacca 1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca 1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat 1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttgatcattg 1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg gaaatgtcca 2091 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag 2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg 2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg 2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaag 2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt 2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg 2401 atccctgtat ttcaagacct ctgtcc (2) INFORMATION FOR SEQ ID N0:2757:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2757 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 291 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 981 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 891 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1191 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1791 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2758:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2758 1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca 121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg 181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat 291 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt 301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt 981 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg 541 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg 601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaaq tgctgggatt 661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt 721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc 781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc 841 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc 901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg 961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct 1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg 1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag 1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag 1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag 1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt 1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact 1441 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc 1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag (2) INFORMATION FOR SEQ ID N0:2759:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2759 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 921 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1191 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca EPI-l09 1035 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2091 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacaca.g caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2760:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2760 1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact 61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag 121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca 181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag 291 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg 301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg 361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa 921 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc 481 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac 541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg 601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag 661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg 721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc 781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc 891 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag 901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc 961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc 1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga 1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag 1141 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc 1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat 1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag 1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc 1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg (2) INFORMATION FOR SEQ ID N0:2761:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2761 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgetgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc (2) INFORMATION FOR SEQ ID N0:2762:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs IB) TYPE: nucleic acid fC) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2762 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttac~c ctaaatgata aaaatcacac actcgagctc (2) INFORMATION FOR SEQ T_~ N0:2763:
(i) SEQUENCE CHARACTERT_STICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic ac_d (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPT=ON: SEQ ID N0:2763 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt (2) INFORMATION FOR SEQ ID N0:2769:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2764 1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca eagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc (2) INFORMATION FOR SEQ ID N0:2765:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2765 1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca (2) INFORMATION FOR SEQ ID N0:2766:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION-: SEQ ID N0:2766 1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag (2) INFORMATION FOR SEQ ID N0:2767:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2767 1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 241 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 591 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg WO 00/09525 PCT/US99/1'7712 601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag 661 tctcactctg ttgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca 1191 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtgattgtg aacaacaaag agaaaaccac 1491 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1741 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagtc agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2391 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg 2401 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2461 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2691 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc 2991 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3241 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg 3921 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3981 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3541 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg 3891 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 9081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4191 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 9201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt (2) INFORMATION FOR SEQ ID N0:2768:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2768 1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 421 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 981 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 891 cccctgtgac aagcactatg ctagatc (2) INFORMATION FOR SEQ ID N0:2769:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2769 1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tqatggtagt ttgtatttgt gtgggatcgg 241 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 421 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 481 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 841 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc 901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca 961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct 1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca 1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1191 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac 1861 aggacacacc gt (2) INFORMATION FOR SEQ ID N0:2770:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2770 1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181.cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 241 cattttgttg gctacttgt~t gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 921 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 481 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg 541 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga 661 tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg EPi-109 1039 841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1191 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1991 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2091 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcctgt agccccagct actcaggtgg ctgaggtggt 2901 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2961 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2691 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3241 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3921 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 9081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4191 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 4201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 4261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 4321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 4441 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 4501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 4561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 9621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 4681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 4791 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 9801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 4861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 4921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5041 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct 5341 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5691 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg 5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg 5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc 5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga 5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag 5941 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg (2) INFORMATION FOR SEQ ID N0:2771:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2771 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 291 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 481 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 591 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt (2) INFORMATION FOR SEQ ID N0:2772:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2772 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 981 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt (2) INFORMATION FOR SEQ ID N0:2773:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2773 1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg 61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag 121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa 181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga 291 gaataccctt gaacctggga ggtggaggtt gcatgacctg a 1 tggacctcaa catgcacacc agtccgagca acaagagcg~ aactccatct caaaaaagaa 61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 921 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 981 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa (2) INFORMATION FOR SEQ ID N0:2774:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2779 1 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa 61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc 121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgctgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag 241 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt 301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg 361 aggccaaggc gggtggatca cctgagatca (2) INFORMATION FOR SEQ ID N0:2775:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear .
(xi)SEQUENCE DESCRIPTION: SEQ ID N0:2775 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata i81 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct (2) INFORMATION FOR SEQ ID N0:2776:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2776 1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag (2) INFORMATION FOR SEQ ID N0:2777:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2777 1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 291 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 921 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 981 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga 541 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc 721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg 781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc 841 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag 901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc 961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa 1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc 1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc 1141 ctagtca (2) INFORMATION FOR SEQ ID N0:2778:
(i) SEQUENCE CHARACTERISTICS:
!A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single !D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2778 1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc 61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag 121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct 181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc 241 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat 301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta 361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac 921 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc 981 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag 591 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccagacca atccaaccag 601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg 661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag 721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag 781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgq tggcagggga 841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt 901 gggcccctca ggtccagggq ttcctctggt gcatgtggcc ctgctccaca atggcctgct 961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt 1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc 1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct 2141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag 1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc 1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag 1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg 1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt 1941 ggactqacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta 1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga 1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag 1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc 1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt 1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc 1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct 1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg 1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac 1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg 2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag 2101 tttcgctctt gatgcccagg ctggggtgca atggag (2) INFORMATION FOR SEQ ID N0:2779:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2779 1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga 61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc 121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg 181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg 241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa 301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg 361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat 921 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat 481 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat 541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca 601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata 661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg 721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc 781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca fiPl-109 1043 841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg 901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta 961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct 1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt 1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga 1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt (2) INFORMATION FOR SEQ ID N0:2780:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2780 1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga (2) INFORMATION FOR SEQ ID N0:2781:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2781 1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat (2) INFORMATION FOR SEQ ID N0:27B2:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2782 1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 421 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt (2) INFORMATION FOR SEQ ID N0:2783:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2783 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga 61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 291 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 921 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 981 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg WO 00/09525 PC'T/US99/177~2 EPI-109 t044 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttcgt tgtcatagcg tggtgaacag agaagagaat gctactgcgt 781 ctcgtggaga gaggcca7gg gataccgcta aacatgcgac aatgcacagg acagtcccct 891 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag (2) INFORMATION FOR SEQ ID N0:2789:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2784 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag 61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg 121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag 181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga 291 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg 301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc 361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac 421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc 481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt 591 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc 601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata 661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg 721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct 781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc 841 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca 901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata 961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc 1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc 1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt 1191 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta 1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga 1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg 1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac 1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg 1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt 1501 gcccatgtca ggactcttgt aaaacagagc tc (2) INFORMATION FOR SEQ ID N0:2785:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xiySEQUENCE DESCRIPTION: SEQ ID N0:2785 1 gagctccagc tttccagctg tcttttggqt gagcctgtct tcctcaagct caagcttcct 61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 241 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 421 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481 ttgaatgagc ac (2) INFORMATION FOR SEQ ID N0:2786:
(i) SEQUENCE CHARACTERISTICS:
~(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2786 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga 61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat EPI-109 ~ p4g 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 981 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt 541 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc 601 ctacagagca ggcatggaga gaaggagaaa tacatacggg caggagccag gagagggagg 661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat 721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt 781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc 891 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg 901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct 961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga 1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa 1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca 1241 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac 1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc 1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag 1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag 1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca 1441 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg 1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca 1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg 1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt 1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca 1791 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg 1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca 1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa 1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta 1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca 2091 gcacttcagg aggctgaggt gggcggatc (2) INFORMATION FOR SEQ ID N0:2787:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2787 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt EPI-!09 1046 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2091 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2901 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2788:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2788 1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg 61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc 121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc 181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca 291 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg 301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg 361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag 421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa 981 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca 591 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg 601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa 661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg 721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct 781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc 841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc 901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg 961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca 1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg 1081 tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc 1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca 1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt 1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca 1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt 1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc 1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa 1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag 1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc 1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca 1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttacagag 1741 aaaaagaggg caaacccttc tatcaaatga cctcaaatgc cacccaggca ttttggacca 1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca 1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat 1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttgatcattg 1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg gaaatgtcca 2041 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag 2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg 2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg 2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaag 2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt 2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg 2401 atccctgtat ttcaagacct ctgtcc 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 6l~tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 981 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc B41 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1491 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2091 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2901 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg 1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca 121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg 181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat 241 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt 301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt 481 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg 591 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg 601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaag tgctgggatt 661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt 721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc 781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc 891 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc 901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg 961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct 1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg 1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag 1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag 1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag 1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt 1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact 1941 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc 1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag ~1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 291 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 921 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 981 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 591 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 9fi1 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1941 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttqggtag aaagagatac agagggg 1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact 61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag 121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca 181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag 241 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg 301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg 361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa 921 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc 981 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac 541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg 601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag 661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg 721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc 781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc 841 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag 901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc 961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc 1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga 1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag 1191 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc 1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat 1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag 1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc 1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt 1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca cagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc 1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca ' 1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag 1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 291 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 591 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg 601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag 661 tctcactctg ttgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca 1141 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtqattgtg aacaacaaag agaaaaccac 1941 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1791 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagtc agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2341 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg 2901 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2961 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2691 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc 2941 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3291 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg 3421 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3481 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3591 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg 3841 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 9081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4141 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 4201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt 1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 921 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 481 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 841 cccctgtgac aagcactatg ctagatc 1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tgatggtagt ttgtatttgt gtgggatcgg 291 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 921 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 981 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 891 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc 901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca 961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct 1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca 1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1141 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac 1861 aggacacacc gt 1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181 cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 291 cattttgttg gctacttgtt gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 421 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 981 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg 591 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga 661~tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg 841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1191 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1441 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2041 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcttgt agccccagct actcaggtgg ctgaggtggt 2901 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2461 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2691 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3291 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3921 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc~tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 4081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4141 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 9201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 9261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 9321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 9941 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 9501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 9561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 4621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 9681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 9741 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 9801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 9861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 9921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5091 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct 5391 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5641 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg 5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg 5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc 5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga 5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag 5991 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 241 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 981 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 541 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 981 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt 1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg 61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag 121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa 181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga 291 gaataccctt gaacctggga ggtggaggtt gcatgacctg a 1 tggacctcaa catgcacacc agtccgagca acaagagcga aactccatct caaaaaagaa 61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 421 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 981 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa 2 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa 61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc 121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgetgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag 291 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt 301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg 361 aggccaaggc gggtggatca cctgagatca 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata 181 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct 1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag 1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 291 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 921 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 481 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga 591 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc 721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg 781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc 891 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag 901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc 961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa 1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc 1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc 1191 ctagtca 1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc 61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag 121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct 181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc 291 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat 301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta 361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac 421 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc 981 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag 541 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccaqacca atccaaccag 601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg 661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag 721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag 781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgg tggcagggga 841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt 901 gggcccctca ggtccagggg ttcctctggt gcatgtggcc ctgctccaca atggcctgct 961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt 1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc 1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct 1141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag 1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc 1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag 1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg 1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt 1991 ggactgacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta 1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga 1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag 1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc 1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt 1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc 1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct 1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg 1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac 1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg 2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag 2101 tttcgctctt gatgcccagg ctggggtgca atggag 1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga 61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc 121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg 181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg 241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa 301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg 361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat 921 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat 981 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat 541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca 601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata 661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg 721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc 781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca 841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg 901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta 961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct 1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt 1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga 1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt 1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga 1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat 1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 921 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga 61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 241 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 921 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 481 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttggt tgtcatagcg tggtgaacag,agaagagaat gctactgcgt 781 ctcgtggaga gaggccaggg gataccgcta aacatgcgac aatgcacagg acagtcccct 841 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag 61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg 121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag 181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga 241 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg 301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc 361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac 421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc 481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt 541 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc 601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata 661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg 721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct 781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc 891 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca 901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata 961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc 1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc 1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt 1141 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta 1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga 1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg 1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac 1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg 1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt 1501 gcccatgtca ggactcttgt aaaacagagc tc 1 gagctccagc tttccagctg tcttttgggt gagcctgtct tcctcaagct caagcttcct 61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 291 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 921 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481' ttgaatgagc ac 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga 61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 981 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt WO 00/09525 PCT/US99/177~2 gp~_~Og 1055 591 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc 601 ctacagagca ggcatggaga gaaggagaaa tacatacqgg caggagccag gagagggagg 661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat 721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt 781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc 891 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg 901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct 961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga 1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa 1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca 1141 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac 1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc 1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag 1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag 1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca 1941 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg 1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca 1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg 1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt 1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca 1791 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg 1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca 1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa 1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta 1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca 2041 gcacttcagg aggctgaggt gggcggatc 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgq tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1191 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1941 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2901 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID N0:2789:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single iD) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2789 1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt 61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg 121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg 181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca 291 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga 301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag 361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt 421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag 481 ttgaatatca cctctcaaaa gcatcacctc tatctgcctc atctcacact gtactctcca 591 ataaagcacc ttgttgaaag as (2) INFORMATION FOR SEQ ID N0:2790:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2790 1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc 61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac 121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct 181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc 241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga 301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc 361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac 921 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac 481 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga 541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct 601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca 661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat 721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag 781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc 841 tggagttcag tggcatgatc atagctcacc acagcttcca actcgtgggc tcaagtgatc 901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa 961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct 1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct 1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc 1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc 1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa 1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag 1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc 1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg 1441 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt 1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc 1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc 1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta 1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca 1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt 1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt 1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat 1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc 1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat 2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac 2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg 2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg 2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg 2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga 2391 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca 2401 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc 2461 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata 2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac 2581 cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc 2691 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg 2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3291 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta (2) INFORMATION FOR SEQ ID N0:2791:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2791 1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct 61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg 121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa 181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta 291 ggagcccgta ggtcatcttg gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct 301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat 361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca 421 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt 981 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct 591 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt 601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca 661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa 721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc 781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg 891 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata 901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc 961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc 1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt 1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat 1191 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca 1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg 1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac 1321 tcaatgtgta cacctttgac tacagctgca gaagtgttcc tttagacaaa gttgtgaccc 1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct 1491 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc 1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc 1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt 1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa 1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat 1791 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga 1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag 1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc 1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat 1981 actactaata taactactgt ttccatgtcc catgatcccc tctcttcctc cccaccctga 2091 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg 2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg 2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg 2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc 2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat 2391 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt 2407. gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta 2961 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct 2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt 2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag 2691 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta 2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac 2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga 2821 gaaactgaaa tccc EPi-109 1058 (2) INFORMATION FOR SEQ ID N0:2792:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (S) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2792 1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt 61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg 121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg 181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca 241 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga 301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag 361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt 421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag 481 ttgaatatca cctctcaaaa qcatcacctc tatctgcctc atctcacact gtactctcca 541 ataaagcacc ttgttgaaag as 1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc 61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac 121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct 181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc 241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga 301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc 361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac 921 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac 981 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga 541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct 601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca 661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat 721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag 781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc 841 tggagttcag tggcatgat~c atagctcacc acagcttcca actcgtgggc tcaagtgatc 901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa 961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct 1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct 1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc 1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc 1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa 1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag 1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc 1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg 1991 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt 1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc 1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc 1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta 1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca 1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt 1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt 1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat 1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc 1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat 2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac 2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg 2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg 2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg 2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga 2341 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca 2901 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc 2961 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata 2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac 2581~cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc 2641 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg 2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3241 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta 1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct 61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg 121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa 181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta 241 ggagcccgta ggtcatcttg gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct 301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat 361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca 921 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt 481 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct 541 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt 601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca 661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa 721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc 781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg 841 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata 901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc 961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc 1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt 1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat 1141 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca 1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg 1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac 1321 tcaatgtgta cacctttgac tacagttgca gaagtgttcc tttagacaaa gttgtgaccc 1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct 1991 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc 1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc 1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt 1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa 1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat 1741 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga 1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag 1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc 1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat 1981 actactaata taactactg't ttccatgtcc catgatcccc tctcttcctc cccaccctga 2091 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg 2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg 2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg 2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc 2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat 2341 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt 2901 gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta 2961 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct 2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt 2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag 2641 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta 2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac 2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga 2821 gaaactgaaa tccc (2) INFORMATION FOR SEQ ID N0:2793:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2793 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 301 ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat 421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt 981 tcagtcaaag aacca (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2799 1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag 61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg 121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta 181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca 291 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg 301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc 361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg 921 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc 981 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct 541 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct 601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt 661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct 721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat 781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg 841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt 901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc 961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa 1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc 1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct 1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag 1201 tccccgggcc ccgagg (2) INFORMATION FOR SEQ ID N0:2795:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2795 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 291 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 921 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgctcga gagccgcgcg 981 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1991 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttc.t ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca (2) INFORMATION FOR SEQ ID N0:2796:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2796 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 591 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc taqtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg (2) INFORMATION FOR SEQ ID N0:2797:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2797 1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc 61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg 121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct 181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc 291 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc 301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg 361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc 421 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg 481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg 541 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg 601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg 661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc 721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc 781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg 841 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc 901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1941 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1791 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg (2) INFORMATION FOR SEQ ID N0:2798:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2798 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 291 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 981 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 891 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1491 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg (2) INFORMATION FOR SEQ ID N0:2799:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2799 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cqccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 291 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 921 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 981 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 891 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1191 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct 1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa (2) INFORMATION FOR SEQ ID N0:2800:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2800 1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg 61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg 121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa 181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg 241 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc 301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc 361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag 421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat 981 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt 541 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc 601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata 661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg 721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg 781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat 841 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca 901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga 961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt 1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa 1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct 1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa 1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc 1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt 1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt 1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag 1441 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt 1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg 1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct 1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg 1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag 1791 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat 1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag 1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac 1921 atttgacaaa taggactgcc tacatttatt attatgaagg tcgattgttg ttggaagtgt 1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt 2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg 2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac 2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg 2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg 2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc 2391 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac 2401 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa 2461 taatctctcc ccaaattttc caataataat tgag (2) INFORMATION FOR SEQ ID N0:2801:
(i) SEQUENCE CHARACTERISTICS:
EPI-) 09 1064 (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2801 1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg 61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc 121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc 181 gaccggcgcg cccctcqgcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc 291 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc 301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct 361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga 421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag 981 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc S41 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg 601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct 661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg 721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg 781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc 841 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg 901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc 961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac 1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa 1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc 1191 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg 1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga 1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca 1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg 1381 aagagagtga gggacagagg aaacgtttat cctggag (2) INFORMATION FOR SEQ ID N0:2802:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2B02 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 30i ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat 421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt 481 tcagtcaaag aacca 1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag 61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg 121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta 181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca 241 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg 301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc 361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg 421 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc 481 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct 591 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct 601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt 661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct 721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat 781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg 841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt 901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc 961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa 1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc 1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct 1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag 1201 tccccgggcc ccgagg 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg WO 00/09525 PCT/US99/177~2 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 921 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg 481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 591 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 891 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1941 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2091 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261~gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1491 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg 1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc 61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg 121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct 181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc 291 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc 301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg 361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc 921 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg 481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg 591 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg 601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg 661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc 721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc 781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg 891 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc 901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1941 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1741 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 291 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 921 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catqaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1191 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1941 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681. gg 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt EPI-l09 1067 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 591 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct 1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa 1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg 61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg 121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa 181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg 291 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc 301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc 361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag 421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat 481 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt 591 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc 601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata 661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg 721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg 781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat 891 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca 901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga 961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt 1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa 1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct 1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa 1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc 1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt 1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt 1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag 1991 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt 1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg 1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct 1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg 1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag 1741 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat 1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag 1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac 1921 atttgacaaa taggactgc~c tacatttatt attatgaagg tcgattgttg ttggaagtgt 1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt 2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg 2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac 2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg 2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg 2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc 2341 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac 2901 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa 2961 taatctctcc ccaaattttc caataataat tgag 1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg 61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc 121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc 181 gaccggcgcg cccctcggcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc 291 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc 301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct 361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga 421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag 981 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc 541 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg 601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct 661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg 721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg 781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc 891 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg 901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc 961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac 1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa 1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc 1141 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg 1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga 1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca 1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg 1381 aagagagtga gggacagagg aaacgtttat cctggag (2) INFORMATION FOR SEQ ID N0:2803:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2803 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 981 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 591 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat B41 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2091 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2901 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2961 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag (2) INFORMATION FOR SEQ ID N0:2809:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs EP!-l09 1069 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2804 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 291 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 981 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1491 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2091 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2391 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2901 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2961 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag (2) INFORMATION FOR SEQ ID N0:2805:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2805 1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct 61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga 121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt 181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac 241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc 301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag 361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag 921 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga 981 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag 541 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac 601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg 661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag 721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa 781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag 841 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct 901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg 961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact 1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca 1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt 1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg 1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc 1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct 1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc 1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact 1991 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg 1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc 1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac 1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag 1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc 1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag 1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac 1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag 1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga 1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc 2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc 2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc 2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc 2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc 2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg 2391 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg 2401 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg 2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg 2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt 2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag 2691 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc 2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag 2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg.tgccctccta 2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag 2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa 2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac 3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg (2) INFORMATION FOR SEQ ID N0:2806:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single 1D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2806 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 591 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781, gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1491 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2091 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2901 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2961 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 921 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 4B1 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 891 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag 1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct 61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga 121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt WO 00/09525 PCT/US99/177~2 EPI-i09 1072 181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac 241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc 301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag 361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag 921 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga 981 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag 591 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac 601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg 661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag 721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa 781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag 891 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct 901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg 961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact 1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca 1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt 1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg 1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc 1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct 1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc 1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact 1441 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg 1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc 1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac 1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag 1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc 1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag 1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac 1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag 1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga 1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc 2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc 2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc 2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc 2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc 2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg 2341 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg 2901 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg 2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg 2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt 2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag 2691 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc 2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag 2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg tgccctccta 2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag 2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa 2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac 3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg (2) INFORMATION FOR SEQ ID N0:2807:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: 5EQ ID N0:2807 1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc 61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag 121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca 181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt 291 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc 301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt 361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct 421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc 981 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga 541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt 601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt 661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg 721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa 7B1 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga 841 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg 901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact 961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat 1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg 1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca 1191 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg 1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt 1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc 1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa 1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg 1941 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata 1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt 1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc 1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag 1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa 1791 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg 1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt 1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg 1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct 1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca 2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac 2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa 2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg 2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat 2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc 2391 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct 2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg 2961 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct 2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct 2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta 2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc 2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg 2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag 2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga 2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata 2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc 3001 aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag 3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct 3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt 3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt 3291 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg 3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc 3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg 3921 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg 3481 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat 3541 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag 3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg 3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt 3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt 3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag 3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat 3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg 4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant 9081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat 9191 ggaaagtcag ggaaaggagg tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc 4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc 9261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag 4321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc 9381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg 9441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat 9501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat 4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg 4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt 9681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt 4741 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat 4801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc 9861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 9921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 9981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5041 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5961 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5991 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6921 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagg cgcatgggtg 7191 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7941 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7741 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg 7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8391 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8401' acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8461 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat 8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg 9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca 9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt 9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag 9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta 9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac 9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg 9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc 9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc 9981 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca 9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg 9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct 9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa 9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc 9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca 9891 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtgatggagg cagcctggag ggctggcact gaaaagagca agggatgggg agggagggcc 9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct 10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa 10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc 10191 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa 10201.agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc 10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac 10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct 10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa 10441 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc 10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc 10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga 10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc 10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag 10791 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac 10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag 10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc 10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc 10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata 11091 acatgg (2) INFORMATION FOR SEQ ID N0:2808:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2808 1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121 atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 291 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 921 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 981 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc 661 tggtcgcagt tcaacaaggt tcagttctcc (2) INFORMATION FOR SEQ ID N0:2809:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2809 1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact 61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt WO 00/09525 PCT/US99/177~2 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 921 gcactttggg aggctgaggc gggcggatca caaggtcaag aaatcgagac catcctgacc 981 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctggqcat ggtggcgcat 591 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc (2) INFORMATION FOR SEQ ID N0:2810:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2810 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat 61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 421 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 481 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 591 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 891 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac 1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1741 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggagat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2901 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2961 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641,ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2991 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac cP~-io9 ~ o~~
3291 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg 3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3421 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3481 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca 3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3841 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg 3961 gtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 9021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 4191 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 4321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc 9441 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 9501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga 4621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 9681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 9741 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 9801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 9861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 9921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 4981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5341 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5901 ccaattctgg gggcaaatgt gcca (2) INFORMATION FOR SEQ ID N0:2811:
(i) SEQUENCE CHARACTERISTICS:
fA) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2811 1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt 61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg 121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag 181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga 241 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc 301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat 361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt 421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt 481 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga 541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta 601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac 661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta 721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct 781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg 891 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt 901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa 961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg 1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg 1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga 1191 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca 1201 ccaactgggg ttggccctta ggtccatgtg ggacattgag atcccagatt gcccatagtg 1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc 1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc 1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga WO 00/09525 PCT/US99/177~2 EPI-l09 1078 1441 tgccacccag cctccactcc caagctgcca ctcac (2) INFORMATION FOR SEQ ID N0:2812:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2812 1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc 61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag 121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca 181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt 241 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc 301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt 361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct 421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc 981 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga 541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt 601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt 661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg 721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa 781 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga 891 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg 901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact 961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat 1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg 1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca 1191 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg 1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt 1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc 1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa 1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg 1441 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata 1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt 1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc 1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag 1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa 1741 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg 1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt 1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg 1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct 1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca 2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac 2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa 2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg 2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat 2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc 2341 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct 2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg 2461 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct 2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct 2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta 2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc 2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg 2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag 2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga 2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata 2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc 3001,aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag 3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct 3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt 3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt 3291 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg 3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc 3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg 3921 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg 3981 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat 3591 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag 3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg 3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt 3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt 3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag 3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat 3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg 4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant 4081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat 9141 ggaaagtcag ggaaaggagg tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc 4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc 9261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag 9321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc 4381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg 9441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat 9501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat 4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg 4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt 4681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt 4791 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat 9801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc 4861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 4921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 4981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5091 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5961 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5941 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6921 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagq cgcatgggtg 7141 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7941 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7791 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg 7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8341 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8901 acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8961 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat 8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg 9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca 9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt 9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag 9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta 9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac 9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg 9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc 9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc 9481 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca 9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg 9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct 9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa 9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc 9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca 9841 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtgatggagg cagcctggag ggctggcact gaaaagagca agggatgggg agggagggcc 9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct 10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa 10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc 10141 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa 10201 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc 10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac 10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct 10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa 10941 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc 10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc 10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga 10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc 10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag 10741 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac 10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag 10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc 10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc 10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata 11091 acatgg 1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121~atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 291 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 921 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 981 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc EPI-109 ' 1081 661 tggtcgcagt tcaacaaggt tcagttctcc -1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact 61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 421 gcactttggg aggctgaqgc gggcggatca caaggtcaag aaatcgagac catcctgacc 481 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcat ggtggcgcat 541 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat 61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 921 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 981 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 541 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 841 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac 1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1791 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggaqat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2401 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2961 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641 ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2941 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac 3241 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg 3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3921 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3981 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc ' 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca 3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3891 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg 3961 qtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 9021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 9191 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 9321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc 4941 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 4501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga 9621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 4681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 4791 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 9801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 4861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 4921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 9981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5391 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5401 ccaattctgg gggcaaatgt gcca 1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt 61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg 121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag 181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga 291 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc 301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat 361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt 421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt 981 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga 541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta 601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac 661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta 721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct 781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg 841 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt 901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa 961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg 1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg 1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga 1141 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca 1201 ccaactgggg ttggccctta ggtccatgtg ggacattgag atcccagatt gcccatagtg 1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc 1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc 1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga 1941 tgccacccag cctccactcc caagctgcca ctcac (2) INFORMATION FOR SEQ ID N0:2B13:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2813 fiP1-t 09 1083 1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga 61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc 121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg 181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag 291 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc 301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg 361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca 421 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg 481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca 591 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc 601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg 661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg 721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt 781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa 841 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa 901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta 961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat 1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat 1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt 1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg 1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga 1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga 1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag 1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa 1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc 1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca 1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag 1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa 1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa 1741 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg 1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt 1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc 1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata 1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta 2091 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta 2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg 2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac 2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact 2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg 2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga 2901 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca 2961 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact 2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg 2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag 2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca 2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg 2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg 2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta 2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata 2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc 3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc 3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt 3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc 3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa 3291 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga 3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca 3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg 3421 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca 3481 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa 3591.attgagagaa tggaaaacag cccgccc (2) INFORMATION FOR SEQ ID N0:2819:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2814 1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga WO 00/09525 PCT/US99/177~2 61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg 121 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc 181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg 241 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg 301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg 361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 421 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 541 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 841 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1491 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2391 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2401 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2991 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3181 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3921 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3981 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3591 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 cttagtgaaa tgacttccgg aatct (2) INFORMATION FOR SEQ ID N0:2815:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2815 1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga 61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc 121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg 181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag 291 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc 301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg 361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca 921 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg 481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca 541 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc 601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg 661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg 721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt 781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa 891 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa 901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta 961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat 1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat 1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt 1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg 1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga 1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga 1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag 1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa 1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc 1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca 1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag 1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa 1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa 1791 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg 1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt 1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc 1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata 1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta 2091 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta 2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg 2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac 2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact 2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg 2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga 2401 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca 2961 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact 2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg 2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag 2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca 2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg 2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg 2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta 2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata 2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc 3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc 3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt 3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc 3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa 3291 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga 3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca 3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg 3921 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca 3981 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa 3541 attgagagaa tggaaaacag cccgccc 1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga 61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg 122 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc 181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg 291 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg 301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg WO 00/09525 PC'T/US99/17712 361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 921 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 591 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 891 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1941 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2341 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2901 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2991 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3161 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3421 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3481 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3591 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 cttagtgaaa tgacttccgg aatct (2) INFORMATION FOR SEQ ID N0:2816:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acizi (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2B16 (2) INFORMATION FOR SEQ ID N0:2817:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2817 (2) INFORMATION FOR SEQ ID N0:2818:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2818 (2) INFORMATION FOR SEQ ID N0:2819:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2819 (2) INFORMATION FOR SEQ ID N0:1:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1108 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:1:
1 cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 291 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa-tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 481 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc 591 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat 1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga 1081 gccagggctg caacttgaag gttttgct (2) INFORMATION FOR SEQ ID N0:2:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 590 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:2:
tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc 61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 241 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 421 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt (2) INFORMATION FOR SEQ ID N0:3:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2022 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:3:
atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac 61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag 121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag 181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac 241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc 301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc 361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa 921 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc 981 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg 541 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct 601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct 661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc 721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg 781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg 841 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc 901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc 1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc 1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc 1191 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac 1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc 1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc 1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg 1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa 1491 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg 1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc 1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg 1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac 1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag 1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg 1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg 1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag 1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat 1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc (2) INFORMATION FOR SEQ ID N0:4:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2500 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:9:
gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 291 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 921 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 981 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 591 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1941 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2391 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID N0:5:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2489 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:5:
gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 891 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccaqtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801, ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2091 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2391 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca EPI-109 ~pgp 2901 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2961 ccataaaaat aaatcagttc attt (2) INFORMATION FOR SEQ ID N0:6:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2997 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:6:
gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg 61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 921 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 981 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga 601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 891 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1191 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1681 ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc 1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg 2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca 2391 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt 2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat 2461 taagaattgg ttgccataaa aataaatcag ttcattt (2) INFORMATION FOR SEQ ID N0:7:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 10151 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:7:
l cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 241 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 981 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc WO 00!09525 PCT/US99l17712 EPI-109 109!
591 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat 1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga 1081 gccagggctg caacttgaag gttttgct tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc 61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 291 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 921 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac 61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag 121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag 181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac 241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc 301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc 361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa 421 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc 981 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg 591 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct 601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct 661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc 721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg 781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg 891 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc 901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc 1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc 1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc 1141 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac 1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc 1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc 1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg 1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa 1991 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg 1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc 1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg 1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac 1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag 1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg 1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg 1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag 1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat 1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 591 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 891 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2091 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1491 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1791 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2391 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg EPI-109 ~ pg3 2461 ccataaaaat aaatcagttc attt gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg 61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 421 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 481 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga 601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 841 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1141 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1681 ccgcctccgc ccagcacgcc gcggtcaacG tcggccagta cgactggtgc tcctggatcc 1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg 2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca 2341 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt 2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat 2961 taagaattgg ttgccataaa aataaatcag ttcattt (2) INFORMATION FOR SEQ ID N0:8:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2383 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:8:
ggcacgaggc tggctgagcc atgatgctgc tgccagaacc cctgcagagg gcctggtttc 61 aggagactca gagtcctctg tgaaaaagcc cttggagagg cgccccagca gggctgcact 121 tggctcctgt gaggaagggg ctcagggtct gggcccctcc gcctgggccg ggctgggagc 181 caggcgggcg gctgggctgc agcaatggac cgtgagctgg cccagcccgc gtccgtgctg 241 agcctgcctg tcgtctgtgg ccatgccatc atgggctcct cggtgtacat cacggtggag 301 ctggccattg ctgtgctggc catcctgggc aatgtgctgg tgtgctgggc cgtgtggctc 361 aacagcaacc tgcagaacgt caccaactac tttgtggtgt cactggcggc ggccgacatc 921 gcagtgggtg tgctcgccat cccctttgcc atcaccatca gcaccgggtt ctgcgctgcc 481 tgccacggct gcctcttcat tgcctgcttc gtcctggtcc tcacgcagag ctccatcttc 541 agtctcctgg ccatcgccat tgaccgctac attgccatcc gcatcccgct ccggtacaat 601 ggcttggtga ccggcacgag ggctaagggc atcattgcca tctgctgggt gctgtcgttt 661 gccatcggcc tgactcccat gctaggttgg aacaactgcg gtcagccaaa ggagggcaag 721 aaccactccc agggctgcgg ggagggccaa gtggcctgtc tctttgagga tgtggtcccc 781 atgaactaca tggtgtactt caacttcttt gcctgtgtgc tggtgcccct gctgctcatg 841 ctgggtgtct atttgcggat cttcctggcg gcgcgacgac agctgaagca gatggagagc 901 cagcctctgc cgggggagcg ggcacggtcc acactgcaga aggaggtcca tgctgccaag 961 tcactggcca tcattgtggg gctctttgcc ctctgctggc tgcccctaca catcatcaac 1021 tgcttcactt tcttctgccc cgactgcagc cacgcccctc tctggctcat gtacctggcc EPI-109 )094 1081 atcgtcctct cccacaccaa ttcggttgtg aatcccttca tctacgccta ccgtatccgc 1141 gagttccgcc agaccttccg caagatcatt cgcagccacg tcctgaggca gcaagaacct 1201 ttcaaggcag ctggcaccag tgcccgggtc ttggcagctc atggcagtga cggagagcag 1261 gtcagcctcc gtctcaacgg ccacccgcca ggagtgtggg ccaacggcag tgctccccac 1321 cctgagcgga ggcccaatgg ctatgccctg gggctggtga gtggagggag tgcccaagag 1381 tcccagggga acacgggcct cccagacgtg gagctcctta gccatgagct caagggagtg 1441 tgcccagagc cccctggcct agatgacccc ctggcccagg atggagcagg agtgtcctga 1501 tgattcatgg agtttgcccc ttcctaaggg aaggagatct ttatctttct ggttggcttg 1561 accagtcacg ttgggagaag agagagagtg ccaggagacc ctgagggcag ccggttccta 1621 ctttggactg agagaaggga gccccaggct ggagcagcat gaggcccagc aagaagggct 1681 tgggttctga ggaagcagat gtttcatgct gtgaggcctt gcaccaggtg ggggccacag 1741 caccagcagc atctttgctg ggcagggccc agccctccac tgcagaagca tctggaagca 1801 ccaccttgtc tccacagagc agcttgggca cagcagactg gcctggccct gagactgggg 1861 agtggctcca acagcctcct gccacccaca caccactctc cctagactct cctagggttc 1921 aggagctgct gggcccagag gtgacatttg acttttttcc aggaaaaatg taagtgtgag 1981 gaaacccttt ttattttatt acctttcact ctctggctgc tgggtctgcc gtcggtcctg 2041 ctgctaacct ggcaccagag cctctgccgg ggagcctcag gcagtcctct cctgctgtca 2101 cagctgccat ccacttctca gtcccagggc catctcttgg agtgacaaag ctgggatcaa 2161 ggacagggag ttgtaacaga gcagtgccag agcatgggcc caggtcccag gggagaggtt 2221 ggggctggca ggccactggc atgtgctgag tagcgcagag ctacccagtg agaggccttg 2281 tctaactgcc tttccttcta aagggaatgt ttttttctga gataaaataa aaacgagcca 2341 catcgtgttt taagcttgtc caaatgaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID N0:9:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2988 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:9:
L catcaccttt ttttaagtag taagaataaa gccactgtat gattctctta atagctatac 61 attaatcctg tttttagtgc tgactgggcc agccttccgg gaactggagt ctgtctcttt 121 cagtgctttt ttgttttttg ttggtttttt cgagacgggg tcgatcacgg ctcaccacag 181 ccttaacctc cagggctcca gcaatcctcc cacctcagcc tcctgagtag ctgggaccac 241 aggtgtgtgc caccatctcc agcagtttgt ttatttattt tttctttttt tttttttggt 301 agaaatgggc ttttcgccca tgttgcccaa gctggtcttg cacttctggg ctgaagcaat 361 cctctcgcct tggcctccca gagccttggg attacagaat catgggtgag agctggcatg 421 gcccctagag gtcatttggg gtccagctgc ctcaccgtat caatgaggaa actgaggccc 481 agaaaagaaa agcatttttg cccagagtcc ctcagaaaaa aacagaccac atctgatcct 541 tggccctgag tccagagtgg gaggcaccgt gacaacaatg cgcagagcag ggaatgcagg 601 gagccatgga tagtgctggg gtgcctcagg aaccctgaag ctgggctgag ccatgatgct 661 gctgccagaa cccctgcaga gggcctggtt tcaggagact cagagtcctc tgtgaaaaag 721 cccttggaga gcgccccagc agggctgcac ttggctcctg tgaggaaggg gctcaggggt 781 ctgggcccct ccgcctgggc cgggctggga gccaggcggg cggctgggct gcagcaatgg 841 accgtgagct ggcccagccc gcgtccgtgc tgagcctgcc tgtcgtctgt ggcatgccca 901 tcatgggctc ctcggtgtac atcacggtgg agctggccat tgctgtgctg gccatcctgg 961 gcaatgtgct ggtgtgctgg gccgtgtggc tcaacagcaa cctgcagaac gtcaccaact 1021 actttgtggt gtcactggcg gcggccgaca tcgcagtggg tgtgctcgcc atcccctttg 1081 ccatcaccat cagcaccggg ttctgcgctg cctgccacgg ctgcctcttc attgcctgct 1191 tcgtcctggt cctcacgcag agctccatct tcagtctcct ggccatcgcc attgaccgct 1201 acattgccat ccgcatcccg ctccggtaca atggcttggt gaccggcacg agggctaagg 1261 gcatcattgc catctgctgg gtgctgtcgt ttgccatcgg cctgactccc atgctaggtt 1321 ggaacaactg cggtcagcca aaggagggca agaaccactc ccagggctgc ggggagggcc 1381 aagtggcctg tctctttgag gatgtggtcc ccatgaacta catggtgtac ttcaacttct 1441 ttgcctgtgt gctggtgccc ctgctgctca tgctgggtgt ctatttgcgg atcttcctgg 1501 cggcgcgacg acagctgaag cagatggaga gccagcctct gccgggggag cgggcacggt 1561 ccacactgca gaaggaggtc catgctgcca agtcactggc catcattgtg gggctctttg 1621 ccctctgctg gctgccccta cacatcatca actgcttcac tttcttctgc cccgactgca 1681 gccacgcccc tctctggctc atgtacctgg ccatcgtcct ctcccacacc aattcggttg 1741 tgaatccctt catctacgcc taccgtatcc gcgagttccg ccagaccttc cgcaagatca 1801 ttcgcagcca cgtcctgagg cagcaagaac ctttcaaggc agctggcacc agtgcccggg 1861 tcttggcagc tcatggcagt gacggagagc aggtcagcct ccgtctcaac ggccacccgc 1921 caggagtgtg ggccaacggc agtgctcccc accctgagcg gaggcccaat ggctatgccc 1981 tggggctggt gagtggaggg agtgcccaag agtcccaggg gaacacgggc ctcccagacg 2091 tggagctcct tagccatgag ctcaagggag tgtgcccaga gccccctggc ctagatgacc 2101 ccctggccca ggatggagca ggagtgtcct gatgattcat ggagtttgcc ccttcctaaq 2161 ggaaggagat ctttatcttt ctggttggct tgaccagtca cgttgggaga agagagagag 2221 tgccaggaga ccctgagggc agccggttcc tactttggac tgagagaagg gagccccagg 2281 ctggagcagc atgaggccca gcaagaaggg cttgggttct gaggaagcag atgtttcatg 2391 ctgtgaggcc ttgcaccagg tgggggccac agcaccagca gcagcatctt tctgggcagg 2401 cccagccctc cactgcagaa gcatctggaa gcaccacctt gtctccacag agcagcttgg 2961 gcacagcaga ctggcctggc cctgagactg gggagtggct ccaacagcct cctgccaccc 2521 acacaccact ctccctagac tctcctaggg ttcaggagct gctgggccca gaggtgacat 2581 ttgacttttt tccaggaaaa atgtaagtgt gaggaaaccc cttttatttt attacctttc 2641 actctctggc tgctgggtct gccgtcggtc ctgctgctaa cctggcagca gagcctctgc 2701 ccggggagcc tcaggcagtc ctctcctgct gtcacagctg ccatccactt ctcagtccca 2761 gggccatctc ttggagtgac aaagctggga tcaaggacag ggagttgtaa cagagcagtg 2821 ccagagcatg ggcccaggtc ccaggggaga ggttggggct ggcaggccac tggcatgtgc 2881 tgagtagcgc agagctaccc agtgagaggc cttgtctaac tgcctttcct tctaaaggga 2941 atgttttttt ctgagataaa ataaaaacga gccacatcgt gttttaag (2) INFORMATION FOR SEQ ID N0:10:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2157 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:10:
ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 291 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 4B1 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1191 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:11:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 999 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: 5EQ ID NO:11:
agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat 61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 291 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg 361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 421 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 591 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc (2) INFORMATION FOR SEQ ID N0:12:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 3739 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:12:
cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc 61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg 121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg 181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg 291 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc 301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact 361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc 921 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct 981 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat 541 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat 601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg 661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct 721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg 781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca 841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc 901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag 961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc 1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca 1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag 1141 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg 1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt 1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa 1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct 1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg 1941 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga 1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg 1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa 1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt 1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca 1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga 1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata 1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg 1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg 1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2901 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2991 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361 taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatag tcccagctac ttgggaggct aaagtggaag gattagttga 3981 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3591 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc (2) INFORMATION FOR SEQ ID N0:13:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 4683 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:13:
agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat 61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 291 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg 361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 921 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 541 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc 61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg 121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg 181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg 241 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc 301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact 361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc 421 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct 481 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat 591 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat 601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg 661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct 721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg 781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca 841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc 901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag 961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc 1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca 1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag 1191 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg 1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt 1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa 1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct 1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg 1941 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga 1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg 1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa 1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt 1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca 1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga 1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata 1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg 1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg EPi-l09 ~ 1098 1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2901 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2941 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361~taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatat~ tcccagctac ttgggaggct aaagtggaag gattagttga 3981 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3541 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc (2) INFORMATION FOR SEQ ID N0:19:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2156 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: 5EQ ID N0:19:
1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 921 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 591 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1791 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2091 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID N0:15:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2955 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:15:
gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca 61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt 121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag 181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct 241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg 301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa 361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg 921 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat 481 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc 591 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc 601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca 661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc 721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt 781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg 891 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg 901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga 961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca 1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc 1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca 1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa 1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg 1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag 1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa 1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt 1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta 1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc 1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa 1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt 1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt 1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca 1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc 1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct 1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag 1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt 2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta 2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg 2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact 2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga 2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa 2341 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc 2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg 2961 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag 2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa 2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca 2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt 2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac 2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg 2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta 2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa 2941 cccagacacc tcctg (2) INFORMATION FOR SEQ ID N0:16:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1995 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/177~2 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:16:
atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat 61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 291 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag 361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 981 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 591 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 841 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc 901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg 961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc 1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag 1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc 1191 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat 1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc 1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt 1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa 1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact 1441 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga (2) INFORMATION FOR SEQ ID N0:17:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 6606 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:17:
ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 291 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 981 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1991 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa 1 gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca 61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt 121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag 181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct 241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg 301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa 361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg 921 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat 981 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc 591 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc 601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca 661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc 721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt 781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg 891 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg 901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga 961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca 1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc 1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca 1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa 1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg 1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag 1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa 1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt 1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta 1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc 1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa 1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt 1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt 1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca 1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc 1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct 1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag 1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt 2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta 2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg 2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact 2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga 2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa 2391 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc 2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg 2961 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag 2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa 2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca 2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt 2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac 2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg 2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta 2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa 2941 cccagacacc tcctg 1 atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat 61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 291 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag 361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 981 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 591 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 891 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc EPt-109 1102 901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg 961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc 1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag 1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc 1191 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat 1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc 1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt 1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa 1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact 1991 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga (2) INFORMATION FOR SEQ ID N0:18:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1068 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:18:
atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 541 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 841 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag (2) INFORMATION FOR SEQ ID N0:19:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:19:
tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac 61 ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag 121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt 181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa 241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg 301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc 361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga 421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg 981 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat 541 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga 601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct 661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc 721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat 781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg 841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc 901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa 961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt 1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga 1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag 1191 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag 1201 t (2) INFORMATION FOR SEQ ID N0:20:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 1699 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:20:
aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct 61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga 121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa 181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 241 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 421 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 481 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 541 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 891 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac 1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa 1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca 1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat 1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct 1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt 1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta 1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca 1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat 1681 gaaaagctt (2) INFORMATION FOR SEQ ID N0:21:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2968 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:21:
atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 591 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 891 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac 61'ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag 121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt 181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa 241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg 301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc 361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga 421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg 981 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat 591 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga EPl-109 1104 601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct 661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc 721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat 781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg 841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc ' 901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa 961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt 1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga 1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag 1191 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag 1201 t 1 aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct 61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga 121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa 181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 291 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 921 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 981 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 591 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 841 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac 1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa 1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca 1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat 1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct 1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt 1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta 1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca 1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat 1681 gaaaagctt (2) INFORMATION FOR SEQ ID N0:22:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 2961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:22:
tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc 61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga 121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg 181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca 291 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa 301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct 361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta 421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat 481 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta 541 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt 601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc 661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct 721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag 781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga 841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaactgttc tctgattctt 901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc 961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac 1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta 1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac 1141 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt 1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag EPl-109 1105 1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctctca aaagaaagat 1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctac~a aggagaacta 1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg 1491 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata 1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag 1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg 1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc 1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca 1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg 1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa 1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg 1921 gccatttcac tctgactaca tcatgtcacc aaacatctga tggtcttg:~.c ttttaattct 1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgcaggct tcccgcattc 2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc 2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat 2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga 2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg 2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctcatgcc tgtaatccca 2391 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagttcgag accagcctgg 2901 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagcttggt gtggtggcgc 2461 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc 2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g (2) INFORMATION FOR SEQ ID N0:23:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 3383 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:23:
agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat 61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa 121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc 181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag 291 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact 301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa 361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg 421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc 481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca 591 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt 601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg 661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt 721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt 781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa 891 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca 901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag 961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa 1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc 1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca 1141 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga 1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg 1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa 1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac 1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt 1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa 1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc 1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg 1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg 1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat 1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg 1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt 1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg qtgttgcaga 1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca 1981 ccaacagccc tcaggtca,:g gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg 2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat 2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga 2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt gaacacactc tcacccagac tccaggctgt ctttcactga atgcttctga 2391 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2901 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2961 ggtgaggatt gattacc~ag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaagg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2991 caaagggaga gagagagctt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID N0:24:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 193068 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:29:
aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 591 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 891 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1791 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2091 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2391 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2691 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatt~aa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2991 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccat:ca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3921 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3891 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 9021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccaacct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 9381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4491 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 9501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 9621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 9681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5091 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5391 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5901 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5691 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6291 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6921 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6981 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6891 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgaca~aaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7191 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8091 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8901 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8961 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8691 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8991 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc 9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9981 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9591 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10491 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10741' cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattc~tag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc EPI-l09 1109 11391 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11961 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12591 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13191 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13491 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 19041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 19221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 19281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 19341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 19961 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 19521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14691 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 19761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 19821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 19941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15291' attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15921 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15891 atgtagagat aaggggc~at gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggaga~at taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagc~tt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaac~ga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattc~ga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcct~ga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt ggggggg=as agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgsga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcacctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttt=at ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17091 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17691 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18591 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19491 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt EPI-l09 1111 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20901 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20961 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20691 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21291 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21921 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21981 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct 21891 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22491 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22791 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23091 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23391 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 29291 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 29421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 29481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 29591 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 29601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 29661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 29901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 29961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25191 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttt~gcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26391 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26901 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27981 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28941 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29091 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29901 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29961 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29691 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29991 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30921 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30981 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30591 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31791 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32901 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32?61 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32991 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 3329T gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33981 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta EPi-109 1114 33891 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 39081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 39191 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 39201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 39261 tggacatttg gqttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 39321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 39491 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 39561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 39621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 39741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 39802 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 39981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35391 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35901 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct 35961 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35691 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36291 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36591 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37791'ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct WO 00/09525 PCT/US99/17?12 38391 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38961 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39921 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39591 tttgatcctt ctagctgtta aggaagaaaa aaataatttt-ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 90321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 90381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 90941 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 90501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 90561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 90621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 90681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 90741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 90801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41091 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41391 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41901 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41961 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 91641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 91761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 91821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42291 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 92921 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 92661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac EPf-109 1116 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagat~aga ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacg~~aa agagctggaa 93081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43191 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 93201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 93261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 93321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43941 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcc~cc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 43791 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 93801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatL:.ga gcaggaggta 93861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 93981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 94101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 49161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 49221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc 49391 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 49401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 99961 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 49521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 94581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 99701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 49821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 94881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 99941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 95121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 45291 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaacta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 95421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 95541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 95601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 95661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 95781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45891 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggaLtg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46191 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 96501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 96621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 96741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 96801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 96861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 97041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 97101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 97161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 97281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47391 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 97901 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 97961 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 97581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 97641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 98001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 98061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 98181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 98291 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48921 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 98481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 98601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 98661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 98781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 98901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 99141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 99321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 99941 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 99681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 99801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 99861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 99921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50091 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctq 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51291 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51921 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51981 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51591 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51891 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctc~;c ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52191 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52941 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52791 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53091 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53961 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53691 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 59061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 59181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 59241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 59921 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54981 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54591 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 59661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 59781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 59841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 59961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55941 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741' ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt EPI-109 ilt9 56391 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56901 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57981 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc.acagagcttc aataatttgg 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59091 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59991 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241' ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60921 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggc~tgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactcagttg cagctgggca EPI~109 1120 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61491 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61791 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62091 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg 62391 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62991 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63591 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 69021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 69381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 69991 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 69501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 69621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 69791 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65901 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65961 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65691 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66921 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67191 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67491 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68391 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69291 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag EPl-109 1122 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70941 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70791 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71391 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71691 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71991 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72291 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72921 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72981 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72891 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73191 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73791'tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 79221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca WO 00/09525 PCf/US99/17712 79341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctct~~ct ccagggttca 74901 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74961 tagctaattt tttgtatttt cagtagagat ggggtttcac catatt~tat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 79641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 79701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 79761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 79881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 79991 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75291 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75921 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag 75891 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76941 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77901 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77961 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77991 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181. gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78921 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccct~tga gtaaagatgt 78591 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79191 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac~agatgggaca ttccttggcc cagtggccag 79791 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80091 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80961 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80691 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81591 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83091 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83961 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83691 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 89001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 89061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 89181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 89291 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 89301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 89421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 89981 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 84591 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 89661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 89721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 89781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact 89841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 89901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 89961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85991 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85791 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86691 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87291 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87891 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88191 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc 89391 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89961 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89691 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89991 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90981 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90891 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa EPt-109 1127 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctg_c~=ggt gtcggcaaaa 92901 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaa~tca gccaaaagaa 92961 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaqgagaaat gttta:~ggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggc7ata aatcagtaac 92691 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgt:~~ca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaac=~ttg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctc=ctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacc:.cctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg caccca~cgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgcct:ctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93921 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt 93891 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgt~ttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagtctg acttgacttt 99021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 99081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctycct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 99381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 94991 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 99741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 99981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcc~ccc accattccaa 95091 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccc:ttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95691 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccac~gtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96291 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96981 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gctta~~ctg gtaaaatata 96891 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97191 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97941 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98091 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98391 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98901 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98691 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt 99291 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat 99981 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg 99891 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100941 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100791 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa EPI-! 09 1129 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101901 ccacttctcc ~cctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101961 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102291 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102921 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag 102981 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102591 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103191 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 109091 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 109161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 109391 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 109521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105247. cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105981 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105591 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact WO 00/09525 PCf/US99/17712 105891 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctcgycaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcat~~aga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatc~~gca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttc~agc ccaaactgaa 106191 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106791 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107091 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca 107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107901 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107991 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108921 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108591 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttqgactgc 109191 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110091 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg WO 00/09525 PC'TNS99/17712 110391 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110961 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttc cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111981 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113961 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113991 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 119241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 119361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114921 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 119481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 119591 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 119661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 119891 atggaaaatg gtaggttwga ttttatgact gaagtggcaa aaagaaataa gggattttat 119901 tatgggggag g:ccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115791 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116391 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116901 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116961 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116691 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116991 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117291 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117591 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117891 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118491 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119091 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt 119391 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119901 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119691 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120291 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120591 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122091 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122391 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122961 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123591 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac EPl-109 I 134 123841 cagacactcc caacagggca agttcatcta actatgtgct cttagt~aga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 129021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 129201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 129261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 129381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 129941 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 129621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124791 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 129801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125391 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125961 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125991 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126291 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126591 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126891 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127191 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127941 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128391 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128961 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128691 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128991 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129591 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129891 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130191 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130791 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131091 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131961 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131991 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132241' agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132921 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132981 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132591 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133191 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgc~c cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133941 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 139041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 139101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 139281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 139341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 139961 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 139521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134691 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 139761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 139881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135981 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135591 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136191 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136991 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc EPl-109 1137 137341 aggcccccgt ggcctct:.tg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137691 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138291 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138921 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139191 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 190041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 190101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 190161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 190641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 190701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 190761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 190941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 191181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141291' aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 191541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 191721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 191781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa WO 00/09525 PC'T/US99/17712 EPI-109 p 3g 191891 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaa~~at gaaagtcaaa 191901 aatacttcta actgaagttg tggggaaatt agaacacttg cagag~~~ca ttccagacag 191961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccc=ggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgat~gtc ctaggtgaat 192081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggt~~gtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtg~aat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccacta;tcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccag~agg gacgctgtcc 192321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 192381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgta~aca acaataccga 192501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcagga=~tc taatgctcac 192561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 192681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactga~cat ttaaaatatg 192791 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID N0:25:
(i) SEQUENCE CHARACTERISTICS:
(A) LENGTH: 199912 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID N0:25:
tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc 61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga 121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg 181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca 241 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa 301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct 361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta 421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat 981 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta 591 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt 601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc 661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct 721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag 781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga 841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaact7ttc tctgattctt 901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc 961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac 1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta 1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac 1191 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt 1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag 1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctctca aaagaaagat 1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctgcta aggagaacta 1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg 1941 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata 1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag 1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg 1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc 1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca 1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg 1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa 1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg 1921.gccatttcac tctgactaca tcatgtcacc aaacatctga tggtct~gcc ttttaattct 1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgca:,gct tcccgcattc 2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc 2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat 2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga 2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg 2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctca~gcc tgtaatccca 2341 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagtt:.gag accagcctgg 2901 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagct~ggt gtggtggcgc 2961 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc 2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat 61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa 121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc 181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag 241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact 301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa 361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg 421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc 481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca 591 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt 601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg 661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt 721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt 781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccagqaa 891 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca 901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag 961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa 1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc 1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca 1191 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga 1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg 1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa 1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac 1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt 1941 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa 1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc 1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg 1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg 1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat 1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg 1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt 1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg gtgttgcaga 1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca 1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg 2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat 2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga 2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt gaacacagtc tcacccagac tccaggctgt ctttcactga atgcttctga 2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaggg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2941 caaagggaga gagagaggtt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ~~gaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 921 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 981 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 591 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1941 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2091 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2961 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2691 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3981 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3891 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 9081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 9201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 9501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 9561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 9741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 9861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact gqttcctcat tcctgaagtt 5091 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5901 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5691 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6291 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6921 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7791 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8901 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8691 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8991 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc s f DEMANDES OU BREVETS VOLUMINEUX
LA PRESENTS PARTiE DE CETTE DEMANDS OU CE BREVET
COMPREND PLUS D'UN TOME.
CECI EST LE TOME ~- _ DE
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Claims (148)
IN UNITED STATES LETTERS PATENT IS:
1. A pharmaceutical composition, comprising a nucleic acid which comprises an oligonucleotide (oligo) consisting of up to about 15% adenosine (A), and which is effective for alleviating or .inhibiting bronchoconstriction, allergy(ies) and/or inflammation, the oligo being anti-sense to a target selected from the group consisting of target genes and their corresponding mRNAs;
genomic and mRNA flanking regions selected from the group consisting of 3' and 5' intron-exon borders and the juxta-section between coding and non-coding regions; and all mRNA segments encoding polypeptides associated with a disease(s) or condition(s) afflicting lung airways;
combinations thereof;
pharmaceutically acceptable salts thereof; and mixtures thereof.
genomic and mRNA flanking regions selected from the group consisting of 3' and 5' intron-exon borders and the juxta-section between coding and non-coding regions; and all mRNA segments encoding polypeptides associated with a disease(s) or condition(s) afflicting lung airways;
combinations thereof;
pharmaceutically acceptable salts thereof; and mixtures thereof.
2. The composition of claim 1, wherein the oligo consists of up to about 10%
A.
A.
3. The composition of claim 2, wherein the oligo consists of up to about 5% A.
4. The composition of claim 3, wherein the oligo consists of up to about 3% A.
5. The composition of claim 4, wherein the oligo is A-free.
6. The composition of claim 1, wherein the target gene is selected from the group consisting of target genes and mRNAs encoding polypeptides selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins; and target genes and mRNAs corresponding to oncogenes, and flanking regions and intron and exon borders.
7. The agent of claim 6, wherein the encoded polypeptides are selected from the group consisting of NfkB Transcription Factor, Interleukin-8 Receptor (IL-8 R), Interleukin 5 Receptor {IL-5 R), Interleukin 4 Receptor (IL-4 R), Interleukin 3 Receptor (IL-3 R), Interleukin-1.beta. (IL-1.beta.), Interleukin 1.beta. Receptor (IL- 1.beta. R), Eotaxin, Tryptase, Major Basic Protein, .beta.2-adrenergic Receptor Kinase, Endothelia Receptor A, Endothelia Receptor B, Preproendothelin, Bradykinin B2 Receptor, IgE High Affinity Receptor, Interleukin 1 (IL-1), Interleukin 1 Receptor (IL-1 R), Interleukin 9 (IL-9), Interleukin-9 Receptor (IL-9 R), Interleukin 11 (IL-11), Interleukin-11 Receptor (IL-11 R), Inducible Nitric Oxide Synthase, Cyclooxygenase (COX), Intracellular Adhesion Molecule 1 (ICAM-1) Vascular Cellular Adhesion Molecule (VCAM), Rantes, Endothelial Leukocyte Adhesion Molecule (ELAM-1), Monocyte Activating Factor, Neutrophil Chemotactic Factor, Neutrophil Elastase, Defensin 1, 2 and 3, Muscarinic Acetylcholine Receptors, Platelet Activating Factor, Tumor Necrosis Factor .alpha., 5-lipoxygenase, Phosphodiesterase IV, Substance P, Substance P Receptor, Histamine Receptor, Chymase, CCR-1 CC Chemokine Receptor, CCR-2 CC Chemokine Receptor, CCR-3 CC Chemokine Receptor, CCR-4 CC
Chemokine Receptor, CCR-5 CC Chemokine Receptor, Prostanoid Receptors, GATA-3 Transcription Factor, Neutrophil Adherence Receptor, MAP Kinase, Interleukin-9 (IL-9), NFAT
Transcription Factors, STAT 4, MIP-l.alpha., MCP-2, MCP-3, MCP-4, Cyclophillins, Phospholipase A2, Basic Fibroblast Growth Factor, Metalloproteinase, CSBP/p38 MAP Kinase, Tryptose Receptor, PDG2, Interleukin-3 (IL-3), Interleukin-1.beta. (IL-1.beta.), Cyclosporin A-Binding Protein, FK5-Binding Protein, .alpha.4.beta.1 Selectin, Fibronectin, .alpha.4.beta.7 Selectin, Mad CAM-1, LFA-1 (CD11a/CD18), PECAM-1, LFA-1 Selectin, C3bi, PSGL-1, E-Selectin, P-Selectin, CD-34, L-Selectin, p150,95, Mac-1 (CD11b/CD18), Fucosyl transferase, VLA-4, CD-18/CD11a, CD11b/CD18, ICAM2 and ICAM3, C5a, CCR3 (Eotaxin Receptor), CCR1, CCR2, CCR4, CCR5, LTB-4, AP-1 Transcription Factor, Protein kinase C, Cysteinyl Leukotriene Receptor, Tachychinnen Receptors (tach R), IkB Kinase 1 & 2, STAT 6, c-mas and NF-Interleukin-6 (NF-IL-6).
Chemokine Receptor, CCR-5 CC Chemokine Receptor, Prostanoid Receptors, GATA-3 Transcription Factor, Neutrophil Adherence Receptor, MAP Kinase, Interleukin-9 (IL-9), NFAT
Transcription Factors, STAT 4, MIP-l.alpha., MCP-2, MCP-3, MCP-4, Cyclophillins, Phospholipase A2, Basic Fibroblast Growth Factor, Metalloproteinase, CSBP/p38 MAP Kinase, Tryptose Receptor, PDG2, Interleukin-3 (IL-3), Interleukin-1.beta. (IL-1.beta.), Cyclosporin A-Binding Protein, FK5-Binding Protein, .alpha.4.beta.1 Selectin, Fibronectin, .alpha.4.beta.7 Selectin, Mad CAM-1, LFA-1 (CD11a/CD18), PECAM-1, LFA-1 Selectin, C3bi, PSGL-1, E-Selectin, P-Selectin, CD-34, L-Selectin, p150,95, Mac-1 (CD11b/CD18), Fucosyl transferase, VLA-4, CD-18/CD11a, CD11b/CD18, ICAM2 and ICAM3, C5a, CCR3 (Eotaxin Receptor), CCR1, CCR2, CCR4, CCR5, LTB-4, AP-1 Transcription Factor, Protein kinase C, Cysteinyl Leukotriene Receptor, Tachychinnen Receptors (tach R), IkB Kinase 1 & 2, STAT 6, c-mas and NF-Interleukin-6 (NF-IL-6).
8. The composition of claim 1, wherein at least one A is substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A1, A2b and A3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a receptor.
9. The composition of claim 8, wherein all As are substituted by universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A1, A2b and A3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a receptor.
10. The composition of claim 8, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH2, SH, SO, SO2, SO3, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH2, primary, secondary and tertiary amine, SH, SO, SO2, SO3 cycloalkyl, heterocycloalkyl and heteroaryl.
11. The composition of claim 10, wherein the pyrimidines and purines are substituted at positions 1, 2,3,4,7and8.
12. The composition of claim 11, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula wherein R1 and R2 are independently H, alkyl, alkenyl or alkynyl and R3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O-cycloalkynyl, NH2-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO2 aryl.
13. The composition of claim 12, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5-nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino-6-methoxyaminopurine.
14. The composition of claim 1, where a methylated cytocine (mC) is substituted for at least one CpG
dinucleotide if present in the oligo(s). .
dinucleotide if present in the oligo(s). .
15. The composition of claim 1, wherein at least one nucleotide linking residue of the anti-sense oligonucleotide(s) is a residue selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), methyleneoxy (methylimino), 2'-O-methyl, phosphoramidate residues and combinations thereof.
16. The agent of claim 15, wherein all nucleotide linking residues are selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), methyleneoxy (methylinmino), 2'-O-methyl, phosphoramidate residues and combinations thereof.
17. The composition of claim 1, wherein the anti-sense oligonucleotide comprises about 7 to 60 mononucleotides.
18. The composition of claim 1, wherein the anti-sense oligonucleotide comprises fragments 1 to 1670 (SEQ ID NOS: 11 through 1680).
19. The composition of claim 1, wherein the anti-sense oligonucleotide is linked to an agent selected from the group consisting of cell internalized or up-taken agent(s) and cell targeting agents.
20. The composition of claim 19, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin, asialoglycoprotein and streptavidin.
21. The composition of claim 19, wherein the nucleic acid is linked to a vector.
22. The vector of claim 21, which comprises a prokaryotic or eukaryotic vector.
23. The composition of claim 1, wherein the oligo is hybridized to a ribonucleic acid.
24. A cell, comprising the agent of claim 1.
25. The composition of claim 1, further comprising a carrier.
26. The composition of claim 25, wherein the carrier comprises a biologically acceptable carrier.
27. The composition of claim 26, wherein the carrier comprises a pharmaceutically or veterinarily acceptable carrier.
28. The composition of claim 25, wherein the carrier is selected from the group consisting of gaseous, liquid, solid carriers and mixtures thereof.
29. The composition of claim 25, further comprising an agent selected from the group consisting of other therapeutic agents, surfactants, antioxidants, flavoring and coloring agents, fillers, volatile oils, buffering agents, dispersants, RNA inactivating agents, anti-oxidants, flavoring agents, propellants and preservatives.
30. The composition of claim 29, comprising the nucleic acid, a surfactant and a carrier.
31. The composition of claim 29, wherein the surfactant is selected from the group consisting of surfactant protein A, surfactant protein B, surfactant protein C, surfactant protein D and surfactant protein and active fragments thereof, non-dipalmitoyl disaturated phosphatidylcholine, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, palmitoyl-lysophosphatidylcholin, dehydroepiandrosterone, dolichols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholine, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, choline, choline phosphate, artificial lamellar bodies vehicles for surfactant components, omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitic acid, non-ionic ethylene and/or propylene oxide block copolymers, polyoxypropylene, polyoxyethylene, poly (vinyl amine) with dextran and/or alkanoyl side chains, Brij 35, Triton X-100, ALEC, Exosurf, Survant and Atovaquone.
32. The composition of claim 31, wherein the RNA inactivating agent comprises an enzyme, preferably a ribozyme.
33. The composition of claim 1, wherein the anti-sense oligonucleotide is present in an amount of about 0.01 to about 99.99 w/w of the composition.
34. The composition of claim 33, wherein the anti-sense oligonucleotide is present in an amount of about 1 to about 40 w/w of the composition.
35. The composition of claim 34, wherein the anti-sense oligonucleotide is present in an amount of about 5 to about 20 w/w of the composition.
36. A formulation, comprising the composition of claim 25, selected from the group consisting of systemic and topical formulations.
37. The formulation of claim 36, selected from the group consisting of oral, intrabuccal, intrapulmonary, rectal, intrauterine, intratunor, intracranial, nasal, intramuscular, subcutaneous, intravascular, intrathecal, inhalable, transdermal, intradermal, intracavitary, implantable, iontophoretic, ocular, vaginal, intraarticular, otical, intravenous, intramuscular, intraglandular, intraorgan, intralymphatic, implantable, slow release and enteric coating formulations.
38. The formulation of claim 37, which is an oral formulation, wherein the carrier is selected from the group consisting of solid and liquid carriers.
39. The oral formulation of claim 38, wherein the liquid carrier is selected from the group consisting of solutions, suspensions, and oil-in-water and water-in-oil emulsions.
40. The oral formulation of claim 38, which is selected from the group consisting of a powder, dragees, tablets, capsules, sprays, aerosols, solutions, suspensions and emulsions.
41. The formulation of claim 36, which is a topical formulation, wherein the carrier is selected from the group consisting of creams, gels, ointments, sprays, aerosols, patches, solutions, suspensions and emulsions.
42. The formulation of claim 36, which is an injectable formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.
43. The formulation of claim 36, which is a rectal formulation in the form of a suppository.
44. The formulation of claim 36, which is a transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.
45. The transdermal formulation of claim 36, which is an iontophoretic transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions, and wherein the formulation further comprises a transdermal transport promoting agent.
46. An implantable capsule or cartridge, comprising the formulation of claim 44.
47. The formulation of claim 36, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.
48. The formulation of claim 36, wherein the carrier comprises a hydrophobic carrier.
49. The formulation of claim 48, wherein the carrier comprises lipid vesicles or particles.
50. The formulation of claim 49, wherein the vesicles comprise liposomes, and the particles comprise microcrystals.
51. The formulation of claim 50, wherein the vesicles comprise liposomes which comprise the anti-sense oligonucleotide.
52. The formulation of claim 49, wherein the vesicles comprise N-(1-[2,3-dioleoxyloxi] propyl)-N,N,N-trimethyl-ammonium methylsulfate.
53. The formulation of claim 36, comprising a respirable or inhalable formulation.
54. The respirable or inhalable formulation of claim 53, comprising an aerosol.
55. The formulation of claim 36, in single or multiple unit form.
56. The formulation of claim 36, in bulk.
57. A kit, comprising a delivery device;
in a separate container, the formulation of claim 36; and instructions for adding a carrier and for use of the formulation.
in a separate container, the formulation of claim 36; and instructions for adding a carrier and for use of the formulation.
58. The kit of claim 57, wherein the delivery device comprises a nebulizer which delivers single metered doses of the formulation.
59. The kit of claim 58, wherein the nebulizer comprises an insufflator; and the composition is provided in a piercable or operable capsule or cartridge.
60. The kit of claim 58, wherein the delivery device comprises a pressurized inhaler; and the composition comprises a suspension, solution or dry formulation of the agent.
61. The kit of claim 57, further comprising, in a separate container, an agent selected from the group consisting of other therapeutic agents, surfactants, anti-oxidants, flavoring agents, fillers, volatile oils, dispersants, antioxidants, propellants, preservatives, buffering agents, RNA inactivating, cell-internalized or up-taken agents and coloring agents.
62. The kit of claim 61, comprising, in separate containers, a nucleic acid, a surfactant and a carrier.
63. The kit of claim 61, wherein the solvent is selected from the group consisting of organic solvents and organic solvents mixed with one or more co-solvents.
64. The kit of claim 57, wherein the composition is provided in a capsule or cartridge.
65. An in vivo method of delivering a nucleic acid comprising an anti-sense oligonucleotide (oligo) to a target polynucleotide associated with a disease(s) or condition(s) afflicting lung airways, comprising administering to a subject the composition of claim 1 comprising an amount of the nucleic acid effective to reach the target polynucleotide.
66. The method of claim 65, wherein the composition is administered into the subject's respiratory system.
67. The method of claim 65, wherein the agent is administered directly into the subject's lung (s).
68. The method of claim 65, wherein the amount of the agent is effective to bind to the nucleic acid.
69. The method of claim 65, wherein the agent is effective to reduce the production or availability, or to increase the degradation, of the target mRNA or to reduce the amount of the target polypeptide present in the lungs.
70. The method of claim 65, wherein the agent is administered as a respirable aerosol.
71. The method of claim 65, wherein the disease or condition is associated with obstruction of the subject's airways.
72. The method of claim 71, wherein the disease or condition is associated with asthma.
73. The method of claim 65, wherein the disease or condition is associated with inflammation.
74. The method of claim 65, wherein the disease or condition is associated with an allergy, and the target is selected from the group consisting of polypeptide and antibody receptor, genes and monas encoding them, their genomic and RNA flanking sequences and exon and intro borders of the gene (s) and RNA(s).
75. The method of claim 65, wherein the disease or condition is associated with a malignancy or cancer, and the mRNA encodes a target selected from the group consisting of immunoglobulins and antibody receptors, genomic flanking sequences and genes and mRNAs encoding them and oncogenes.
76. The method of claim 65, wherein the composition is administered by a transdermal or systemic route.
77. The method of claim 76, wherein the composition is administered orally, intracavitarily, intranasally, intraanally, intravaginally, intrautecally, intraarticularly, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intravascularly, intratumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascuiarly, intrathecally, intralymphatically, intraotically, by implantation, by inhalation, intradermally, intrapulmonarily, intraotically, by slow release, by sustained release and by a pump.
78. The method of claim 65, wherein the subject is a mammal.
79. The method of claim 78, wherein the mammal is selected from the group consisting of humans and animals.
80. The method of claim 79, wherein the mammal is a human.
81. The method of claim 79, wherein the subject is an animal.
82. The method of claim 65, wherein the anti-sense oligonucleotide is administered in amount of about 0.005 to about 150 mg/kg body weight.
83. The method of claim 82, wherein the anti-sense oligonucleotide is administered in an amount of about 0.01 to about 75 mg/kg body weight.
84. The method of claim 83, wherein the anti-sense oligonucleotide is administered in an amount of about 1 to 50 mg/kg body weight.
85. The method of claim 65, which is a prophylactic method.
86. The method of claim 65, which is a therapeutic method.
87. The method of claim 65, wherein the oligo is obtained by (a) selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C;
(b) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15%; and (c) obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an A
base content of up to and including about 15%.
(b) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15%; and (c) obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an A
base content of up to and including about 15%.
88. The method of claim 61, wherein the oligo consists of up to about 10% A.
89. The method of claim 88, wherein the oligo consists of up to about 5% A.
90. The method of claim 88, wherein the oligo consists of up to about 3% A.
91. The method of claim 92, wherein the oligo is A-free.
92. The method of claim 65, wherein the target is selected from the group consisting of genes and mRNAs encoding polypeptides selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides, peptide receptors and binding proteins; and genes and mRNAs corresponding to oncogenes.
93. The method of claim 65, wherein at least one A is substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A1, A2b and A3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a, receptor.
94. The method of claim 93, wehrein all As are substituted by universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A1, A2b and A3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a receptor.
95. The method of claim 95, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH2, SH, SO, 502, SO3, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH2, primary, secondary and tertiary amine, SH, SO, SO2, SO3, cycloalkyl, heterocycloalkyl and heteroaryl.
96. The method of claim 95, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.
97. The method of claim 96, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula wherein R1 and R2 are independently H, alkyl, alkenyl or alkynyl and R3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O-cycloalkynyl, NH2-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO2 aryl.
98. The method of claim 97, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5-nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino-6-methoxyaminopurine.
99. The method of claim 65, further comprising methylating at least one cytocine (mC) if a CpG
dinocleotide if present in the oligo(s).
dinocleotide if present in the oligo(s).
100. The method of claim 65, further comprising substituting at least one nucleotide linking residue of the anti-sense oligonucleotide(s) with a residue selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), methyleneoxy (methylimino), 2'-O-methyl, phosphoramidate residues, and combinations thereof.
101. The method of claim 100, wherein all nucleotide linking residues of the oligo are substituted.
102. The method of claim 65, further comprising linking the anti-sense oligonucleotide to an agent selected from the group consisting of cell internalized and up-taken agent(s) and cell targeting agents.
103. The method of claim 102, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin, asialoglycoprotein, and streptavidin.
104. The method of claim 102, wherein the cell targeting agent is a vector.
105. The method of claim 104, wherein the vector to which the agent is operatively linked is a prokaryotic or eukaryotic vector.
106. A method of identifying segments in a target polynucleotide suitable for constructing oligonucleotides which are anti-sense to the target polynucleotide and have an adenosine (A) content of up to and including about 15% of all nucleotides, comprising (a) selecting fragments of a target polynucleotide acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C; and (a) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G content of up to and including about 15%.
107. A method of obtaining oligonucleotides which are anti-sense to a target polynucleotide and have an adenosine content of 0 to up to and including about 15%, comprising conducting the method of claim 106;
wherein the first oligonucleotide comprises a sequence which is anti-sense to the selected fragment and has an A
content of up to and including about 15%.
wherein the first oligonucleotide comprises a sequence which is anti-sense to the selected fragment and has an A
content of up to and including about 15%.
108. The method of claim 107, further comprising, when the anti-sense fragment comprises at least one A, substituting at least one A with a universal base selected from the group consisting of heteroaromatic bases which bind to thymidine (T) but have less than about 0.3 of A's adenosine A1, A2b and A3 receptor agonist activity; and heteroaromatic bases which have no activity or have adenosine A2a receptor agonist activity.
109. The method of claim 108, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH2, SH, SO, SO2, SO3, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH2, primary, secondary and tertiary amine, SH, SO, SO2, SO3, cycloalkyl, heterocycloalkyl and heteroaryl.
110. The method of claim 109, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.
111. The method of claim 109, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula wherein R1 and R2 are independently ~, alkyl, alkenyl, or alkynyl or alkynyl and R3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O-cycloalkynyl, NH2-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO2 aryl.
112. The method of claim 108, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5-nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino-6-methoxyaminopurine.
113. A method of heating a disease or condition associated with a target selected from the group consisting of proteins, gene (s) and their corresponding mRNA(s) encoding the proteins, the genes and mRNA
flanking regions and their intron and exon borders, associated with a disease or condition afflicting lung airways, comprising administering to a subject afflicted with the disease or condition the composition of claim 1 comprising an anti-bronchoconstriction, anti-allergic and/or anti-inflammatory effective amount of the nucleic acid.
flanking regions and their intron and exon borders, associated with a disease or condition afflicting lung airways, comprising administering to a subject afflicted with the disease or condition the composition of claim 1 comprising an anti-bronchoconstriction, anti-allergic and/or anti-inflammatory effective amount of the nucleic acid.
114. The method of claim 113, wehrein the amount of nucleic acid administered is effective to reduce the production or availability, or to increase the degradation, of the mRNA, or to reduce the amount of the polypeptide present in the lungs.
115. The method of claim 113, wherein the nucleic acid is administered directly to the lung (s) of the subject.
116. The method of claim 113, wherein the nucleic acid is administered as a respirable aerosol.
117. The method of claim 113, wherein the disease or condition is a disease or condition afflicting the lung (s).
118. The method of claim.117, wherein the disease or condition is associated with obstruction of the subject's airways.
119. The method of claim 117, wherein the disease or condition is associated with asthma.
120. The method of claim 117, wherein the disease or condition is associated with inflammation.
121. The method of claim 113, wherein the disease or condition is associated with allergy (ies), and the target is selected from the group consisting of immunoglobulins and antibody receptors, gene(s) and corresponding mRNA(s) encoding them, the genes and mRNA flanking regions and intron and exon borders.
122. The method of claim 113, wherein the disease or condition is associated with a malignancy or cancer; and the target is selected from the group consisting of immunoglobulins and antibody receptors, gene(s) and mRNA(s) encoding them, gene(s) and mRNA(s) associated with oncogenes, genomic and mRNA flanking regions and exon and intron borders.
123. The method of claim 113, wherein the composition is administered by a topical or systemic route.
124. The method of claim 123, wherein the composition is administered orally, intracavitarily, intranasally, intraanally, intravaginally, intrauterally, intraarticularly, intraotically, intralymphatically, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intratumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascularly, intrathecally, by implantation, by inhalation, intradermally, intrapulmonarily, into the ear, by slow release, by sustained release and by a pump.
125. The method of claim 124, wherein the subject is a mammal.
126. The method of claim 125, wherein the mammals are selected from the group consisting of humans and animals.
127. The method of claim 113, wherein the anti-sense oligonucleotide is administered in amount of about 0.005 to about 150 mg/kg body weight.
128. The method of claim 127, wherein the anti-sense oligonucleotide is administered in an amount of about 0.01 to about 75 mg/kg body weight.
129. The method of claim 130, wherein the anti-sense oligonucleotide is administered in an amount of about 1 to about 50 mg/kg body weight.
130. The method of claim 113, which is a prophylactic method.
131. The method of claim 113, which is a therapeutic method.
132. A method of producing anti-sense oligonucleotide(s) (oligos) consisting of up to and including about 15% adenosine (A), comprising selecting a target from the group consisting of polypeptides associated with a disease(s) and/or condition(s) afflicting lung airways, genes and RNAs encoding them, the genomic and mRNA flanking regions and the gene(s) and mRNA(s) intron and exon borders;
obtaining the sequence of a mRNA(s) selected from the group consisting of mRNAs corresponding to the target gene(s) and mRNAs encoding the target polypeptide(s), genomic and mRNA
flanking regions and the genes and mRNAs intron and exon borders;
selecting at least one segment of the mRNA(s);
synthesizing one or more oligo anti-sense to the selected mRNA segment(s); and substituting, if necessary, a universal base(s) for one or more A(s) to reduce the content of A present in the oligo to up to about 15% of all nucleotides.
obtaining the sequence of a mRNA(s) selected from the group consisting of mRNAs corresponding to the target gene(s) and mRNAs encoding the target polypeptide(s), genomic and mRNA
flanking regions and the genes and mRNAs intron and exon borders;
selecting at least one segment of the mRNA(s);
synthesizing one or more oligo anti-sense to the selected mRNA segment(s); and substituting, if necessary, a universal base(s) for one or more A(s) to reduce the content of A present in the oligo to up to about 15% of all nucleotides.
133. The method of claim 132, wherein the universal base is selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A1, A2b and A3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a, receptor.
134. The method of claim 132, wherein all As are substituted with universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A1, A2b and A3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a, receptor.
135. The method of claim 133, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH2, SH, SO, SO2, SO3, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH2, primary, secondary and tertiary amine, SH, SO, SO2, SO3, cycloalkyl, heterocycloalkyl and heteroaryl.
136. The method of claim 135, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4,7and8.
137. The method of claim 135, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula wherein R1 and R2 are independently H, alkyl, alkenyl or alkynyl and R3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O-cycloalkynyl, NH2-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO2 aryl.
138. The method of claim 135, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5-nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino-6-methoxyaminopurine.
139. The method of claim 132, wherein the proportion of A in the oligo is reduced to up to about 10%.
140. The method of claim 139, wherein the proportion of A in the oligo is reduced to up to about 5%.
141. The method of claim 140, wherein the proportion of A in the oligo is reduced to up to about 3%.
142. The method of claim 141, wherein the proportion of A in the oligo is reduced to about 0.
143. The method of claim 139, wherein the selected segment contains loss than about 15% T.
144. The method of claim 132, further comprising substituting a methylated cytosine for cytosine in at least one CpG dinucleotide present in the anti-sense oligo(s).
145. The method of claim 132, wherein the anti-sense oligo(s) are about 7 to about 60 nucleorides long.
146. The method of claim 132, wherein the target is selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, selectins, defensines, growth factors, vasoactive peptides, vasoactive peptide receptors, and binding proteins and oncogenes.
147. The method of claim 146, wherein the target genes are selected from the group consisting of oncogenes.
148. An anti-sense oligonucleotide produced by the method of claim 132.
Applications Claiming Priority (3)
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| US60/095,212 | 1998-08-03 | ||
| PCT/US1999/017712 WO2000009525A2 (en) | 1998-08-03 | 1999-08-03 | Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments |
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|---|---|
| CA2333901A1 true CA2333901A1 (en) | 2000-02-24 |
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| CA002333901A Abandoned CA2333901A1 (en) | 1998-08-03 | 1999-08-03 | Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments |
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Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825174B2 (en) | 1995-06-07 | 2004-11-30 | East Carolina University | Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation |
| US7034007B1 (en) | 1995-06-07 | 2006-04-25 | East Carolina University | Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion |
| WO2000058468A2 (en) * | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | 47 human secreted proteins |
| JP2002539811A (en) * | 1999-03-26 | 2002-11-26 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 48 human secreted proteins |
| BR0006019A (en) * | 1999-04-06 | 2001-03-13 | Univ East Carolina | Low adenosine antisense oligonucleotide, compositions, kit & method for treating airway disorders associated with bronchoconstriction, lung inflammation, allergy (s) & surfactant depletion |
| US6489151B1 (en) * | 2000-03-27 | 2002-12-03 | The Research Foundation Of State University Of New York | Biologically active alternative form of the IKKα IκB kinase |
| DE10019252A1 (en) * | 2000-04-18 | 2001-10-31 | Klaus Karl Degitz | Polydeoxyribonucleotides to inhibit ICAM-1 gene expression |
| DE10049549A1 (en) * | 2000-10-06 | 2002-05-02 | Markus Hecker | Inhibitor of the transcription factor IFR-1, useful for treating e.g. transplant rejection and autoimmune disease, reduces expression of CD40 |
| DK1406667T3 (en) * | 2001-07-06 | 2008-06-16 | Topigen Pharmaceuticals Inc | Methods to increase in vivo efficacy of oligonucleotides and inhibit mammalian inflammation |
| EP1492885A2 (en) * | 2002-04-05 | 2005-01-05 | University Court of the University of Edinburgh | Schizophrenia associated genes |
| AR040996A1 (en) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | IMMUNE STIMULATING NUCLEIC ACIDS |
| CN1322899C (en) * | 2004-02-11 | 2007-06-27 | 中国科学院上海生命科学研究院 | Anti cancer gene medicinal composition, micromolecule interfere RNA and its screening method |
| ES2450929T3 (en) | 2004-10-29 | 2014-03-25 | Topigen Pharmaceuticals Inc. | Antisense oligonucleotides to treat allergy and proliferation of neoplastic cells |
| EP1926747A1 (en) | 2005-08-12 | 2008-06-04 | Schering Corporation | Mcp1 fusions |
| US8524217B2 (en) | 2010-05-11 | 2013-09-03 | Merck Sharp & Dohme Corp. | MCP1-Ig fusion variants |
| US10017762B2 (en) * | 2010-11-24 | 2018-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for treating or preventing lupus |
| RU2584573C2 (en) * | 2011-06-15 | 2016-05-20 | Грайфолз Терепьютикс Инк. | Methods, compositions and kits for detection of human immunodeficiency virus (hiv) |
| CN102866153B (en) * | 2012-09-29 | 2014-08-13 | 郑州安图生物工程股份有限公司 | Prostatitis joint-detection kit |
| JP2016513968A (en) * | 2013-03-11 | 2016-05-19 | ユニバーシティー オブ ノースキャロライナ アット チャペル ヒルＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ | Compositions and methods targeting O-linked N-acetylglucosamine transferase and compositions and methods for promoting wound healing |
| EP4237436A2 (en) * | 2020-10-29 | 2023-09-06 | Mariano A. Garcia-Blanco | Soluble interleukin-7 receptor (sil7r) modulating therapy to treat cancer |
Family Cites Families (7)
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|---|---|---|---|---|
| DE637965T1 (en) * | 1991-11-26 | 1995-12-14 | Gilead Sciences Inc | INCREASED FORMATION OF TRIPLE AND DOUBLE HELICOS FROM OLIGOMERS WITH MODIFIED PYRIMIDINES. |
| US5858784A (en) * | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US6498147B2 (en) * | 1992-05-22 | 2002-12-24 | The Scripps Research Institute | Suppression of nuclear factor-κb dependent processes using oligonucleotides |
| US5994315A (en) * | 1995-06-07 | 1999-11-30 | East Carolina University | Low adenosine agent, composition, kit and method for treatment of airway disease |
| US5856462A (en) * | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| US5932557A (en) * | 1997-08-12 | 1999-08-03 | Mustafa; S. Jamal | Adenosine A1 receptor antisense oligonucleotide treatment of alcohol and marijuana-induced psychomotor impairments |
| EP1080225A4 (en) * | 1998-05-21 | 2004-02-04 | Isis Pharmaceuticals Inc | Compositions and methods for the pulmonary delivery of nucleic acids |
-
1999
- 1999-08-03 EP EP99939006A patent/EP1102786A4/en not_active Withdrawn
- 1999-08-03 WO PCT/US1999/017712 patent/WO2000009525A2/en active Search and Examination
- 1999-08-03 CN CN99809303A patent/CN1317009A/en active Pending
- 1999-08-03 CA CA002333901A patent/CA2333901A1/en not_active Abandoned
- 1999-08-03 AU AU53374/99A patent/AU5337499A/en not_active Abandoned
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2002
- 2002-04-08 HK HK02102614.0A patent/HK1042706A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1102786A2 (en) | 2001-05-30 |
| EP1102786A4 (en) | 2002-03-06 |
| WO2000009525A3 (en) | 2000-05-18 |
| AU5337499A (en) | 2000-03-06 |
| HK1042706A1 (en) | 2002-08-23 |
| CN1317009A (en) | 2001-10-10 |
| WO2000009525A2 (en) | 2000-02-24 |
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