TW202305132A - Antisense oligonucleotides for inhibiting alpha-synuclein expression - Google Patents

Abstract

The present disclosure provides antisense oligonucleotides for regulating expression of alpha-synuclein and use thereof to treat synucleinopathies.

Description

Antisense oligonucleotides for inhibiting α-synuclein expression

α-synuclein is a protein encoded by the SNCA gene, which is mainly expressed in the central nervous system (including neocortex, hippocampus, substantia nigra, thalamus and cerebellum). In neurons, expression of α-synuclein is localized at the synaptic front and this protein is thought to be a chaperone involved in the assembly and function of the SNARE complex. At least three different isoforms of α-synuclein are known, which result from alternative splicing of the SNCA gene transcript. α-synuclein is involved in the regulation of many different neuronal functions and properties, including synaptic transmission, synaptic vesicle density, and neuronal plasticity.

In some cases, α-synuclein aggregates and forms insoluble fibrils. Alpha-synuclein aggregates are thought to be involved in many different neurological diseases including Parkinson's disease, Lewy body dementia, Alzheimer's disease and multiple system atrophy ) pathology. The pathogenic role of α-synuclein in disease progression has been genetically validated. For example, missense mutations in the SNCA gene cause the rare familial form of Parkinson's disease. Duplication or triple duplication of the wild-type gene can also cause rare cases of Parkinson's disease, and overexpression of wild-type α-synuclein alone has been shown to be sufficient to cause the disease.

Disorders caused by misfolding or aggregation of alpha-synuclein are collectively referred to as synucleinopathies. Multiple system atrophy (MSA), a rapidly progressive synucleinopathy, results from the misfolding and accumulation of α-synuclein, leading to the formation of glial cytoplasmic inclusions (GCIs) in oligodendritic cells. GCI is widespread in the nervous system of MSA patients, but some regions (including the basal ganglia, cerebellum, pons, and spinal cord) are more affected than others. At the microscopic level, the neuropathological features of MSA include moderate gliosis, hypomyelination, and neuronal loss and axonal degeneration in the striosnigral and olivopontocerebellar systems.

Alpha-synuclein can exist in tissues in several different forms including, for example, monomers, oligomers, or fibril complexes, and can be phosphorylated. It is currently unclear which of these protein species is responsible for synucleinopathy. Therefore, knowing which form of this protein to target for the development of drugs to treat synucleinopathies at the protein level is challenging.

There is currently a lack of acceptable options for the treatment of synucleinopathies. Accordingly, there remains a need for compounds, methods and pharmaceutical compositions for the treatment of these disorders.

The present invention provides antisense oligonucleotides (ASOs) that reduce the abundance or activity of RNA transcribed from SNCA genes. By reducing the amount of SNCA RNA, the compounds of the invention reduce the abundance of alpha-synuclein in cells. Thus, the ASOs described herein reduce alpha-synuclein, its accumulation and aggregates, which can reduce symptoms and/or delay disease progression.

In some aspects, the invention provides an oligonucleotide comprising a nucleotide sequence of 15 to 30 (e.g., 16 to 20) contiguous nucleotides, wherein the nucleotide sequence is identical to that appearing in SEQ ID NO : Complementary to a region of the same length of the following nucleotides in 1: a) 16350 to 16450, b) 18926 to 19030, c) 22250 to 22471, d) 22933 to 23079, e) 23408 to 23700, f) 29753 to 29819, g) 38128 to 38158, h) 39852 to 39906, i) 53762 to 53799 or j) 59754 to 59865. In some embodiments, the nucleotide sequence contains no more than 3 mismatches to the region. For example, the nucleotide sequence may contain 0, 1 or 2 mismatches to the region. In particular embodiments, the nucleotide sequence is single-stranded. The nucleotide sequence may be selected from, for example, SEQ ID NO: 18 to 40.

In some embodiments, the oligonucleotides described herein can comprise one or more ribonucleotides, one or more deoxyribonucleotides, or a combination of both.

In some embodiments, the oligonucleotides described herein may comprise one or more modified nucleotides. Such modified nucleotides may include, for example, 2'-O-methoxyethyl (2'-MOE) nucleotides, locked nucleic acid (LNA) nucleotides, bridging nucleic acid (BNA) nucleotides , or any combination thereof.

In some embodiments, all cytosines in the oligonucleotides described herein are 5-methylcytosine.

In some embodiments, the oligonucleotides described herein may comprise phosphodiester internucleoside linkages and/or phosphorothioate internucleoside linkages. In certain embodiments, the oligonucleotide may comprise at least 1, 2, 3, 4 or 5 phosphodiester internucleoside linkages. In certain embodiments, at least 1, 2, 3, 4 or 5, or all, of the internucleoside linkages in the oligonucleotide are phosphorothioate internucleoside linkages.

In some embodiments, the oligonucleotides described herein comprise: i) 5-10-5 MOE spacer; ii) 4-10-4 MOE spacer; iii) 3-10-3 LNA spacer; iv) 3-11-3 LNA spacer; v) 3-2-10-2-3 LNA/MOE spacer; vi) 2-3-10-3-2 BNA/MOE spacer; vii) 3-2-10-2-3 BNA/MOE spacer; or viii) 2-3-10-3-2 LNA/MOE spacer.

In certain embodiments, the oligonucleotide comprises: i) 3-2-10-2-3 LNA/MOE spacer; ii) 2-3-10-3-2 BNA/MOE spacer; iii) 3-2-10-2-3 BNA/MOE spacer; or iv) 2-3-10-3-2 LNA/MOE spacer; wherein the internucleoside linkage between the following nucleosides is a phosphodiester internucleoside linkage: v) 2 and 3, 4 and 5, 16 and 17, and 18 and 19; vi) 2 and 3, 4 and 5, and 16 and 17; vii) 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18; or viii) 3 and 4, 4 and 5, 16 and 17, and 17 and 18 ; and the remainder of the internucleoside linkages are phosphorothioate internucleoside linkages.

In certain embodiments, oligonucleotides described herein comprise the formula: i) Als Tlo mCls Aeo mCes mCds Tds Tds mCds Ads Ads Ads mCds mCds mCds mCeo Tes Tlo Tls mCl (SEQ ID NO: 34), ii) Abs Tbs mCeo Aeo mCes mCds Tds Tds mCds Ads Ads Ads mCds mCds mCds mCeo Teo Tes Tbs mCb (SEQ ID NO: 20), iii) Als Alo Tls Aeo Ges mCds Ads Tds mCds mCds Tds Tds mCds mCds Ads mCeo Aes mClo mCls Al (SEQ ID NO: 33), iv) Abs Abs Teo Aeo Ges mCds Ads Tds mCds mCds Tds Tds mCds mCds Ads mCeo Aeo mCes mCbs Ab (SEQ ID NO: 19), v) Gbs mCbs Aeo Geo Tes Tds mCds Tds Ads Tds mCds mCds mCds Ads mCds Teo mCeo Aes Tbs mCb (SEQ ID NO: 18), vi) mCbs mCbs Geo Geo Tes Gds mCds mCds Ads Tds Tds Ads mCds Tds mCds mCeo mCeo Tes Tbs Tb (SEQ ID NO: 21), vii) Tbs Tbs Geo mCeo Aes Gds Ads Tds Ads Ads Ads mCds mCds Ads Tds mCeo mCeo mCes Abs mCb (SEQ ID NO: 22), viii) Abs Gbs Teo Geo mCes mCds Ads Gds Ads mCds mCds mCds Tds Tds Tds mCeo Aeo Tes Tbs Ab (SEQ ID NO: 23), ix) mCbs mCbs Aeo Aeo Ges Tds Gds mCds mCds Ads Gds Ads mCds mCds mCds Teo Teo Tes mCbs Ab (SEQ ID NO: 24), x) Gbs mCbs Aeo Geo Aes Tds Ads Ads Ads Ads mCds mCds Ads Tds mCds mCds mCeo Aeo mCes Tbs Tb (SEQ ID NO: 25), xi) mCbs Gbs Geo Teo Ges mCds mCds Ads Tds Tds Ads mCds Tds mCds mCds mCeo Teo Tes Tbs mCb (SEQ ID NO: 26), xii) Gbs Abs Aeo mCeo Tes Gds Ads Tds Gds mCds mCds Tds mCds Tds Ads mCeo mCeo Tes mCbs mCb (SEQ ID NO: 27), xiii) Abs mCbs Teo Geo Aes Ads mCds Tds Gds Ads Tds Gds mCds mCds Tds mCeo Teo Aes mCbs mCb (SEQ ID NO: 28), xiv) Tbs Abs mCeo Aeo Tes Gds Gds mCds mCds Ads Gds Ads Ads Ads mCds mCeo Aeo mCes Tbs Tb (SEQ ID NO: 29), xv) Abs Abs Geo mCeo mCes Ads Ads Gds mCds mCds mCds Ads Ads Ads Ads mCds Aeo mCeo Tes Abs Ab (SEQ ID NO: 30), xvi) Tbs mCbs mCeo Aes Aes Ads Gds Gds Ads Gds mCds Ads mCds mCds Ads Aeo mCeo mCes Abs Ab (SEQ ID NO: 31), xvii) Gls mClo Als Geo Tes Tds mCds Tds Ads Tds mCds mCds mCds Ads mCds Teo mCes Alo Tls mCl (SEQ ID NO: 32), xviii) mCls mClo Gls Geo Tes Gds mCds mCds Ads Tds Tds Ads mCds Tds mCds mCeo mCes Tlo Tls Tl (SEQ ID NO: 35), xix) Tls Tlo Gls mCeo Aes Gds Ads Tds Ads Ads Ads Ads mCds mCds Ads Tds mCeo mCes mClo Als mCl (SEQ ID NO: 36), xx) Als Glo Tls Geo mCes mCds Ads Gds Ads mCds mCds mCds Tds Tds Tds mCeo Aes Tlo Tls Al (SEQ ID NO: 37), xxi) mCls mClo Als Aeo Ges Tds Gds mCds mCds Ads Gds Ads mCds mCds mCds Teo Tes Tlo mCls Al (SEQ ID NO: 38), xxii) Gls mClo Als Geo Aes Tds Ads Ads Ads Ads mCds mCds Ads Tds mCds mCds mCeo Aes mClo Tls Tl (SEQ ID NO: 39), xxiii) mCls Glo Gls Teo Ges mCds mCds Ads Tds Tds Ads mCds Tds mCds mCds mCeo Tes Tlo Tls mCl (SEQ ID NO: 40), xxiv) Gls Alo Als mCeo Tes Gds Ads Tds Gds mCds mCds Tds mCds Tds Ads mCeo mCes Tlo mCls mCl (SEQ ID NO: 41), xxv) Als mClo Tls Geo Aes Ads mCds Tds Gds Ads Tds Gds mCds mCds Tds mCeo Tes Alo mCls mCl (SEQ ID NO: 42), xxvi) Tls Alo mCls Aeo Tes Gds Gds mCds mCds Ads Gds Ads Ads Ads mCds mCeo Aes mClo Tls Tl (SEQ ID NO: 43), xxvii) Als Alo Gls mCeo mCes Ads Ads Gds mCds mCds mCds Ads Ads Ads Ads mCds Aeo mCes Tlo Als Al (SEQ ID NO: 44), xxviii) Tls mClo mCls Aeo Aes Ads Gds Gds Ads Gds mCds Ads mCds mCds Ads Aeo mCes mClo Als Al (SEQ ID NO: 45), in A series adenine, mC is 5-methylcytosine, G series guanine, T series thymine, e is 2'-MOE modified ribose, d series 2'-deoxyribose, b-series BNA, L series LNA, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

。 In some embodiments, the present invention provides an oligonucleotide comprising the following structural formula:

.

。 In some embodiments, the present invention provides an oligonucleotide comprising the following structural formula:

.

。 In some embodiments, the present invention provides an oligonucleotide comprising the following structural formula:

.

。 In some embodiments, the present invention provides an oligonucleotide comprising the following structural formula:

.

The invention also provides an oligonucleotide conjugate comprising an oligonucleotide described herein.

In some aspects, the invention provides a pharmaceutical composition comprising an oligonucleotide as described herein or an oligonucleotide conjugate as described herein, and a pharmaceutically acceptable excipient.

Also provided herein is a method of reducing alpha-synuclein expression in a mammalian cell comprising contacting the cell with an oligonucleotide, oligonucleotide conjugate, or pharmaceutical composition described herein, thereby reducing the expression of alpha-synuclein in the cell α-synuclein expression in . In some embodiments, the cell is a central nervous system cell, such as a cell in the human brain. In some embodiments, the present invention provides a method for treating a synucleinopathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an oligonucleotide, oligonucleotide conjugate described herein or a pharmaceutical composition. In certain embodiments, the synucleinopathy is Parkinson's disease, Lewy body dementia, Alzheimer's disease or multiple system atrophy. The oligonucleotide can be injected, for example, intrathecally or intracranially into the individual. In certain embodiments, the oligonucleotide reduces the amount of SNCA mRNA by at least 25, 50, 75, or 80% in murine primary cortical neurons engineered to express human alpha-synuclein.

It will be appreciated that any of the oligonucleotides, oligonucleotide conjugates, and pharmaceutical compositions described herein may be used in any method of treatment as described herein, may be used in any treatment as described herein, and/or may be used in to manufacture a medicament for any of the treatments as described herein.

Other features, objects and advantages of the present invention will be apparent from the following embodiments. However, it should be understood that the embodiments, while indicating examples and aspects of the present invention, are given by way of illustration only and not limitation. Various changes and modifications within the scope of the invention will become apparent from this embodiment to those skilled in the art.

sequence listing

This application contains a Sequence Listing, which has been filed electronically in ASCII format and is hereby incorporated by reference in its entirety. The ASCII copy created on March 6, 2021 is named 027628_WO002_SLfinal.txt and is 718,553 bytes in size.

The present invention is based on the discovery that antisense oligonucleotides (ASOs) targeting RNA transcribed from SNCA genes can effectively reduce the abundance of target SNCA gene transcripts and/or the transcription of α-synuclein polypeptides from them This translation. The ASO of the present invention comprises a sequence that is complementary to SNCA transcripts and binds to specified nucleotide sequences within these transcripts.

By reducing the amount or translational activity of SNCA target transcripts in cells, ASO mediates a reduction in the expression and accumulation of α-synuclein in the cells, reducing the severity or progression of neurodegenerative diseases. The ASOs of the present invention are expected to be particularly useful in the treatment of synucleinopathies caused by accumulation or aggregation of alpha-synuclein. The protein may be expressed in the cell, eg, in monomeric or oligomeric form, and may be phosphorylated or unphosphorylated. Since it is unclear which of these α-synuclein species is the causative factor of the disease, it has been challenging to date to develop effective therapeutics that target α-synuclein expression or activity at the protein level. The ASOs of the present invention are highly advantageous because they target α-synuclein expression at the SNCA transcript level and thus have the ability to reduce the expression of all the above forms of α-synuclein. I. SNCA gene and α- synuclein

The ASO of the present invention binds to the transcript of the SNCA gene, which encodes alpha-synuclein, also known as the SNCA protein. The SNCA gene is also called α-synuclein, NACP , non-A-β component of AD amyloid, PARK1 , PARK4 or PDI gene. In some embodiments, the ASOs described herein target transcripts of mammalian SNCA genes (eg, murine or human SNCA genes).

The sequence of the human SNCA gene is publicly available under GenBank accession number NC_000004.12. The gene is 137,980 bps in length and located on chromosome 4:89700345..89838324 (SEQ ID NO: 2). A portion of the human genome SNCA sequence is shown in SEQ ID NO: 1, and a partial sequence of the pre-mRNA transcript can be found at GenBank accession number NG_011851.1 (residues 6001 to 8400). The mature mRNA transcript is shown in SEQ ID NO:3. In some embodiments, the ASO of the present invention binds to the SNCA sequence or transcripts thereof, selected from chromosome 4:89,700,345-89,838,315 (reverse strand) and their accession numbers NM_000345.3, NT_016354.20 TRUNC 30800000- 30919000, JN709863.1, BC013293.2, NM_001146055.1, HQ830269.1 and NC_000004.12 (89724099..89838324, complement). In some embodiments, an ASO of the invention binds to a SNCA transcript encoding alpha-synuclein, eg, as found under UniProt accession numbers P37840, A8K2A4, Q13701, Q4JHI3, or Q6IAU6. In certain embodiments, an ASO of the invention comprises a sequence that is at least 60, 70, 80, 85, 90, or 95%, or 100%, complementary to a sequence of the same length in a target SNCA transcript.

In some embodiments, an ASO of the invention can bind to a transcript of a wild-type SNCA gene (eg, a wild-type human, non-human primate, or murine gene). In some embodiments, an ASO of the invention binds to a variant (such as a known variant) of the wild-type SNCA gene. Known variants include, for example, forms of the human SNCA gene in which the G209A substitution results in an A53T mutation in the alpha-synuclein encoded by that gene. Further known variants have nucleotide mutations that result in mutant α-synuclein comprising A30P, E46K, H50Q, and G51D amino acid substitutions. Such substitutions may be found alone or in combination with other mutations. ASOs of the invention can be designed to reduce or inhibit expression of wild-type or variant SNCA transcripts. In certain embodiments, an ASO described herein reduces or inhibits the expression of a SNCA transcript encoding α-synuclein having one or more mutations selected from A30P, E46K, H50Q, G51D, and A53T.

The ASO of the present invention comprises a sequence complementary to a sequence of the same length in a target transcript encoded by a SNCA gene (wherein the gene body SNCA sequence may comprise, for example, SEQ ID NO: 1). In certain embodiments, the ASOs described herein comprise sequences that are complementary to sequences in hotspot regions within target SNCA nucleic acids. The term "hotspot region" refers to a region of a target nucleotide sequence in which binding of a complementary ASO to a sequence within that region tends to result in a decrease in the abundance or translational activity of the target RNA transcript. Hotspots can be entirely within an intron, entirely within an exon, or can span an intron/exon junction; or be located entirely or partially within the 5' or 3' untranslated region (UTR) of the RNA transcript .

In some embodiments, an ASO described herein may comprise a sequence that binds to a target sequence within or overlaps with any of several different hotspot regions of a SNCA gene transcript. Table A lists exemplary hotspots in the human SNCA gene and identifies ASOs of the invention designed to complement them. The table also shows that when neurons from humanized SNCA- inserted mice were treated with selected ASOs targeting this hotspot, there was minimal reduction in SNCA gene transcripts observed in vitro (see, e.g., below entitled "In Vitro Analysis") Materials and Methods" section). Throughout the present invention, the compound is referred to interchangeably as SNCA_ASO_[Compound No.] and as [Compound No.]. For example, Compound No. SNCA_ASO_01608 and Compound No. 01608 represent the same antisense oligonucleotide compound. In certain embodiments, the binding of an ASO described herein to a sequence in a hotspot region reduces the amount of SNCA RNA in a cell by at least 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70% %, 75%, 80%, 90% or 100% (eg, in an in vitro assay such as described below in the section entitled "Materials and Methods for In Vitro Assay"). In particular embodiments, the ASOs of the present invention may be ASOs listed in Table A, or at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% identical in sequence thereto The ASO. Table A: Human SNCA gene hotspots targeted by antisense oligonucleotides hotspot Nucleotide position in SEQ ID NO:1 Selected ASOs targeting this hotspot Minimal reduction in SNCA gene transcript 1 16350-16450 01529, 00838, 00537 66% 2 18926-19030 00554, 00555, 00556, 00557, 00558 80% 3 22245-22471 01040, 01179, 01054, 01009, 01018, 01078, 01052, 01155, 01182, 01217, 01115, 01135, 01209, 01315, 01137, 01125, 00568, 00569, 00570, 00985 30% 4 22932-23079 00576, 01001, 00993, 00577, 01002, 01021, 01096, 01081, 01152, 01141, 01253, 01184, 01319, 01351, 01279, 01265 25% 5 23408-23700 00578, 00579, 00580, 00581, 00582, 00583, 00584, 00585, 00587, 00588 55% 6 29753-29819 00615, 00616, 00617, 01011, 01036, 00618, 01014, 00619, 00994, 01013, 01003, 01151, 01117 54% 7 38127-38158 01317, 01195, 01357, 01355, 01346, 01269, 01244, 01136, 01187, 01261, 01260, 01270 42% 8 39852-39906 00646, 00647, 0068, 00649, 01027, 01066, 01247, 01268, 01289, 01280, 01105, 01127, 00651, 00653, 00653, 00998, 01153, 01104, 01143, 01041,01606060, 010437 01016 41% 9 53762-53799 01138, 01294, 01211, 01231, 01164, 01306, 01343, 01338 50% 10 59754-59865 01248, 01252, 01275, 01123 58% II. Antisense oligonucleotides

The term "antisense oligonucleotide" or "ASO" refers to an oligonucleotide that hybridizes to a sequence in a target transcript. Those skilled in the art will appreciate that the ASOs described herein do not occur in nature (ie, they are "isolated" ASOs).

The term "transcript" refers to any RNA transcribed from a gene (eg, the SNCA gene). The gene may be wild-type or may be in mutated or variant (eg, polytypic) form. The RNA transcript can be a primary RNA transcript or a precursor messenger RNA (pre-mRNA), or a messenger RNA (mRNA), and can include exons, introns, 5'UTRs, and 3'UTRs. Unless otherwise indicated, the sequences of transcripts and ASOs provided herein represent the nucleotide sequence from the 5' end (left) to the 3' end (right).

The term "oligonucleotide" as used in the present invention refers to a nucleic acid comprising about 5 to 100 nucleosides, e.g., 5 to 50 nucleosides, e.g., 8 to 30 nucleosides, linked via internucleoside linkages. Shares of compounds. The individual nucleosides and internucleoside linkages of the oligonucleotides of the invention may be modified or unmodified from naturally occurring nucleotides and linkages. Modified oligonucleotides may comprise one or more modified sugar moieties, one or more modified nucleobases, and/or one or more modified internucleoside linkages.

An ASO described herein may comprise a sequence that is substantially or completely complementary to a sequence of the same length in a target transcript. When the first strand of consecutive nucleotides (modified or unmodified) and the second strand of consecutive nucleotides (modified or unmodified) are in the shorter strand (or both strands if they are the same length) Perfect complementarity occurs when they are completely complementary to each other over their entire length. When the two strands are more than 80% or more (for example, 90% or more) base-paired with each other over the length of the shorter strand (or if they are the same length, the two strands), and the base-pairing error When matching no more than 20% (for example, no more than 10%) (for example, for a duplex of 20 nucleotides, no more than 4 or no more than 2 mismatched base pairs), the two strands are considered to be roughly complement each other. In some embodiments, the sequences in the ASOs of the invention are 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100% complementary to the target RNA transcript. In some embodiments, an ASO of the invention comprises no more than 1, 2 or 3 mismatches with its target sequence.

The terms "identical" or "identity" in the context of comparing two nucleotide sequences refer to the same nucleobases. The term "percent identity" in this context refers to the maximum corresponding alignment (with gaps introduced, if necessary) over the length of the shorter compared sequences (or if the compared sequences are of the same length, the two sequences) The percentage of identical nucleobases when comparing the two sequences.

In some embodiments, the expression or activity of the target transcript is observed to be reduced, inhibited or eliminated compared to a control sample not treated with ASO. In some embodiments, an ASO of the invention reduces the abundance and/or translational activity of a target SNCA transcript in a treated sample, for example, by 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% or 100%. In certain instances, the ASO reduces the amount of the target transcript in vivo by the percentage, and administration of the ASO optionally results in less than 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 ( For example, a tolerance score (functional observation group or FOB score) of 0). The terms "reducing" and "inhibiting" do not necessarily mean completely eliminating the total amount and/or activity of a transcript. In some embodiments, an ASO is considered active when it reduces the amount or activity of a target RNA by 25% or more in an in vitro assay. ASOs of the invention can cause detectable or measurable changes in the amount or activity of α-synuclein encoded by the target RNA.

Without wishing to be bound by theory, it is believed that ASO can inhibit the expression of α-synuclein by recruiting the RNase H1 enzyme to the double helix formed between ASO and the target SNCA transcript. Enzymes of the RNase H1 family are endonucleases that typically target the RNA:DNA duplex and catalyze the hydrolytic cleavage of RNA in the duplex.

In some embodiments, the ASO has minimal off-target effects and does not hybridize to any non- SNCA transcript in a manner that results in a significant reduction in the abundance or activity of the non- SNCA transcript. A. Length of antisense oligonucleotide

In some embodiments, the ASOs of the invention are between 8 and 30 nucleotides in length (e.g., 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 , 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 nucleotides). In some embodiments, the ASOs described herein may comprise sequences complementary to the SNCA transcript sequence of the same length with upper limits of 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, Any of 29 or 30 and independently selected lower limit nucleotide length ranges of 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20.

In certain embodiments, the complementary sequence in the ASO is between 16 and 20 nucleotides in length. In specific embodiments, the complementary sequence in the ASO is 16, 17, 18 or 20 nucleobases in length. B. Modification of antisense oligonucleotides

In some embodiments, an ASO of the invention may comprise one or more modifications, e.g., to increase binding affinity for a target transcript, to increase ASO stability (e.g., to increase resistance to degradation (e.g., by nucleases)) , and/or increase the convenience of ASO transport into cells. Modifications may include any known in the art, including, for example, terminal modifications, nucleobase modifications, sugar modifications or substitutions, and backbone modifications. Terminal modifications can include, for example, 5' and/or 3' end modifications (eg, phosphorylation, conjugation, DNA nucleotides, and reverse linkage). Base modifications can include, for example, substitution with stabilizing bases, removal of bases, or incorporation of bases. Sugar modifications or substitutions may include, for example, modifications at the 2' and/or 4' positions of the ribose moiety, or substitution of the ribose moiety. Backbone modifications or internucleoside linkage modifications can include, for example, phosphodiester linkages, for example, via one or more phosphorothioate, phosphorodithioate, phosphotriester, methyl phosphonate, and other alkyl Modification or substitution of base esters, phosphinates, and phosphoramidates.

In some embodiments, an ASO of the invention may have one or more modified nucleosides. The term "nucleoside" refers to a compound comprising a nucleobase and a sugar moiety. Naturally occurring nucleosides include DNA and RNA nucleosides. In non-naturally occurring nucleosides (also known as "modified nucleosides" or "nucleoside analogs"), the base and/or the sugar have been modified. The modification of the nucleoside may be "silent", in which case the modified nucleoside has the same or equivalent function within the context of the oligonucleotide as compared to the naturally occurring nucleoside. In other cases, modified nucleosides can increase the effectiveness of the ASO in reducing the abundance or activity of target transcripts. The term utility encompasses targeted engagement of SNCA mRNA.

The term "nucleotide" as used herein refers to a nucleoside covalently bound to one or more modified or unmodified internucleoside linkages. Exemplary nucleotides include monophosphates, diphosphates, triphosphates, and phosphorothioates. As used herein, the term "nucleotide" includes unmodified nucleotides (ie, naturally occurring nucleotides) and modified nucleotides (ie, nucleotide analogs). The term "nucleoside" includes unmodified nucleosides (i.e., naturally occurring nucleosides) and modified nucleosides (i.e., nucleoside analogs); and the term "nucleobase" includes unmodified nucleobases bases (ie, naturally occurring nucleobases) and modified nucleobases (ie, nucleobase analogs).

(I) In some embodiments, modified nucleosides comprise modified nucleobases. In certain embodiments, the modified nucleobase is a 5-methylcytosine (5mC) nucleobase, as shown in Structure (I) below, wherein R represents a sugar moiety.

(I)

(II) In some embodiments, sugar moieties can be modified or unmodified sugar moieties. As used herein, an unmodified sugar moiety refers to a 2'-OH(H) nucleoside moiety as found in naturally occurring RNA, also known as an unmodified RNA sugar moiety. In some embodiments, the modified sugar moiety can be a 2'-H(H) deoxyribose moiety. This moiety occurs naturally in deoxyribonucleic acid and may be referred to as an unmodified DNA sugar moiety or simply a DNA sugar moiety. The structure of the 2'-deoxynucleoside sugar moiety is shown in Structure (II) below, where R represents a nucleobase, and each of the 5'-hydroxyl and 3'-hydroxyl groups of the sugar participate in an internucleoside bond as desired couplet.

(II)

(III) In some embodiments, the modified sugar moiety may comprise an O-methoxyethyl (MOE) moiety. In some embodiments, the O-methoxyethyl moiety is at the 2' position of the sugar, as shown in structure (III) below. R in the structures below represents a nucleobase. Each of the 5'-hydroxyl and 3'-hydroxyl groups of the sugar participates in internucleoside linkages as necessary. 2'-MOE modified sugars or 2'-MOE modified nucleosides (or simply MOE sugars or nucleosides) are those in which the naturally occurring 2' hydroxyl group in the ribose is replaced by a 2'OCH ₂ CH ₂ OCH ₃ group ribose or nucleosides.

(III)

(IV) In some embodiments, the modified sugar moiety can comprise a bridging nucleic acid (BNA) moiety. The bridging nucleic acid comprises a bicyclic sugar moiety. The sugar moiety contains a 4'- _CH2 -NH-O-2' linkage. The nitrogen system of the bridging nucleic acid is optionally substituted (eg, methylated, alkylated, or phenyl modified). The structure of the BNA moiety is shown in (IV) below, where R is a nucleobase, R' is, for example, H, Me, or phenyl, and each of the 5'-hydroxyl and 3'-hydroxyl of the sugar is Required to participate in internucleoside linkages. In the present ASO, unless otherwise specified, R' is a Me group. BNA-modified nucleosides (or simply BNA nucleosides) are nucleosides that comprise a BNA sugar moiety.

(IV)

(V) In some embodiments, the modified sugar moiety can comprise a locked nucleic acid (LNA) moiety. Locked nucleic acids comprise bicyclic sugar moieties. The sugar moiety contains a 4'- _CH2 -O-2' linkage. LNA moieties as described herein can be in either the alpha-L configuration or the beta-D configuration. In specific embodiments, the LNA moiety in the ASOs described herein is in the β-D configuration. The structure of the LNA moiety is shown in (V) below, where R is the nucleobase and each of the 5'- and 3'-hydroxyl groups of the sugar participate in internucleoside linkages as required. LNA modified nucleosides (or simply LNA nucleosides) are nucleosides comprising an LNA sugar moiety.

(V)

In certain embodiments, the ASOs described herein may include one or more modified nucleotides known in the art, including, for example, 2'-O-methyl modified nucleotides, 2'-fluoro-modified nucleotides, 2'-deoxy-modified nucleotides, 2'-O-methoxyethyl-modified nucleotides, modified cores that allow for substitution of internucleoside linkages Nucleotides (e.g., nucleotides comprising phosphorothioate, phosphorothioate, and phosphotriesters), modified nucleotides terminally linked to cholesterol derivatives or lipophilic moieties, peptide nucleic acids, inverted deoxy or Dideoxy-modified nucleotides, abasic modifications of nucleotides, 2'-amine-modified nucleotides, phosphoramidate-modified nucleotides, sugars or bases in oligonucleotides Other positions of bases include modified modified nucleotides, and modified nucleotides containing unnatural bases.

In some embodiments, an ASO may include one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20) modified nucleosides. In certain embodiments, all nucleosides in the ASO are modified nucleosides. In other embodiments, less than 100% of the nucleosides (e.g., less than 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, or 10%) of the ASO are modified nucleosides.

The ASOs of the invention may comprise naturally occurring and/or non-naturally occurring internucleoside linkages. The term "internucleoside linkage" as used in the present invention refers to a covalent linkage between adjacent nucleosides in an oligonucleotide. In certain embodiments, the ASOs described herein may include one or more modified nucleoside linkages known in the art, including, for example, phosphates, phosphotriesters, phosphoborates, methylphosphine Ester, phosphoroamidate, phosphorothioate, phosphorodithioate linkage, methylenemethylimino (-CH ₂ -N(CH ₃ )-O-CH ₂ -), sulfur diester , Thiocarbamate (-OC(=O)(NH)-S-), Siloxane (-O-SiH ₂ -O-), Dialkylsiloxane, N,N'-Di Methylhydrazine (-CH ₂ -N(CH ₃ )-N(CH ₃ )-), MMI (3'-CH ₂ -N(CH ₃ )-O-5'), Amide-3 (3'- CH ₂ -C(=O)-N(H)-5'), amido-4 (3'-CH ₂ -N(H)-C(=O)-5'), amido-5 (3 '-N(H)-C(=O)-CH ₂ -5'), amide-6 (3'-C(=O)-N(H)-CH ₂ -5'), methylal ( 3'-O-CH ₂ -O-5'), methoxypropyl, thioformal (3'-S-CH ₂ -O-5'), carboxylate, carboxamide, sulfide , sulfonate, or amide linkers. See, eg, Carbohydrate Modifications in Antisense Research; Eds. YS Sanghvi and PD Cook, CS Symposium Series 580; Chapters 3 and 4, 40-65.

In certain embodiments, the ASOs described herein may include one or more modified nucleoside linkages known in the art, including, for example, phosphonoacetate (PACE, P(CR'R '') _n COOR) or thiophosphonoacetate (thioPACE, (S)-P(CR'R'') _n COOR) internucleoside linkages, wherein n is an integer from 0 to 6 and R' and R'' are independently selected from the group consisting of H, alkyl, and substituted alkyl. Examples of such internucleoside linkages include phosphonylcarboxylate, phosphonylcarboxylate, thiophosphonylcarboxylate, and thiophosphonylcarboxylate linkages, and in some embodiments , described in Yamada et al., J. Am. Chem. Soc. (2006) 128(15):5251-61, the content of which is incorporated herein by reference in its entirety.

In certain embodiments, the internucleoside linkage of nucleotides may be a phosphate group or a phosphorothioate group. Methods for the preparation of phosphorous-containing internucleoside linkages are well known to those skilled in the art. In certain embodiments, the ASOs described herein can have phosphodiester internucleoside linkages, phosphorothioate internucleoside linkages, or combinations thereof. The term "phosphodiester internucleoside linkage" refers to an internucleoside linkage between two nucleosides formed by a phosphodiester group. The term "phosphorothioate internucleoside linkage" refers to a modified internucleoside linkage in which one of the non-bridging oxygen atoms of the phosphodiester internucleoside linkage is replaced by a sulfur atom.

In certain embodiments, internucleoside linkages with chiral atoms may be prepared as racemic mixtures, or may be prepared as individual enantiomers. Representative internucleoside linkages with chiral centers include, but are not limited to, alkyl phosphonates and phosphorothioates. ASOs of the invention comprising internucleoside linkages with one or more chiral centers can be prepared as populations of ASOs comprising atactic internucleoside linkages, or as comprising stereo-defined internucleoside linkages The ASO group.

The term "stereo-defined internucleoside linkage" in the present invention refers to an internucleoside linkage in which the stereochemical designation of the phosphorus atom is controlled so that a specific amount of _Rp or _Sp of the internucleoside linkage exists within the ASO strand. link. The stereochemical names of chiral linkages can be defined, for example, by asymmetric synthesis. An ASO having at least one stereodefined internucleoside linkage may be referred to as a stereodefined ASO.

In some embodiments, the ASOs of the present invention are fully stereodefined. The term "fully stereodefined ASO" as used in the present invention refers to an ASO sequence having a designated chiral center (R _p or _Sp ) within each internucleoside linkage in the ASO. The term "partially defined ASO" as used in the present invention refers to a defined chiral center ( _Rp or S) in at least one, but not all, of the internucleoside linkages of the ASO. _p ) ASO sequence. Thus, a partially stereodefined ASO may include chiral or non-sterically defined linkages in addition to at least one stereodefined linkage.

In certain embodiments, the population of modified oligonucleotides is enriched for modified oligonucleotides comprising one or more specific phosphorothioate internucleoside linkages in a specific stereochemical configuration. In certain embodiments, the particular configuration of the particular phosphorothioate linkage is present in at least 65%, 70%, 80%, 90%, or 99% of the molecules of the population. Such chiral-enriched populations of modified oligonucleotides can be generated using synthetic methods known in the art, such as, for example, Oka et al., JACS (2003) 125:8307; Wan et al., Nuc. Acid. Res. (2014) 42:13456; and the method described in PCT Patent Publication WO 2017/015555.

Unless otherwise indicated, the chiral internucleoside linkages of the modified oligonucleotides described herein may be atactic or in a particular stereochemical configuration. C. Antisense oligonucleotide conjugates

The invention also provides antisense oligonucleotide conjugates (ASO conjugates) comprising one or more ASOs described herein. The term "ASO conjugate" in the present invention refers to an oligomeric compound comprising an antisense oligonucleotide covalently linked to one or more non-nucleotide moieties (conjugate moieties). Conjugation of oligonucleotides to one or more conjugate moieties can improve the pharmacological or pharmacokinetic properties of the ASO. For example, the conjugate moiety can affect the activity, cellular distribution, cellular uptake, binding, absorption, tissue distribution, cellular distribution, charge, clearance, bioavailability, metabolism, excretion, permeability and/or stability of the ASO . In particular, the conjugate moiety can help target the ASO to specific regions in the central nervous system. In some embodiments of the ASOs described herein, the conjugate moiety can be a carbohydrate, a peptide (eg, a cell surface receptor ligand), and/or a lipid (eg, a phospholipid).

PCT Patent Publications WO 1993/07883 and WO 2013/033230 provide conjugate moieties suitable for use with the ASOs of the invention. Certain conjugate groups and conjugate moieties have been previously described, for example, in the following references: Thioether moieties, e.g., hexyl-S-tritylthiol (Manoharan et al., Ann. NY. Acad. Sci. (1992) 660:306-309; Manoharan et al., Bioorg. Med. Chem. Lett. (1993) 3:2765-70), phospholipids, for example, hexacyl-rac-glycerol or 1,2 - Triethyl-ammonium di-O-hexadecyl-rac-propanetrioxy-3-H-phosphonate (Manoharan et al., Tetrahedron Lett. (1995) 36:3651-4; Shea et al. , Nucl. Acids Res. (1990) 18:3777-83), polyamine or polyethylene glycol chains (Manoharan et al., Nucleosides & Nucleotides (1995) 14:969-73), or adamantaneacetic acid, tocopheryl (Nishina et al., Molecular Therapy Nucleic Acids (2015) 4:e220; and Nishina et al., Molecular Therapy (2008) 16:734-40), or the GalNAc moiety (e.g., PCT Patent Publication WO 2014/076196, WO 2014/207232 and WO 2014/179620).

In certain embodiments, the conjugation of an ASO of the invention to a lipophilic moiety increases delivery of the ASO to cells of the central nervous system. The term "lipophilic moiety" in the present invention broadly refers to any compound or chemical moiety that has an affinity for lipids. The lipophilic moiety may generally comprise a saturated or unsaturated hydrocarbon chain, which may be cyclic or acyclic. The hydrocarbon chain may contain various substituents and/or one or more heteroatoms, such as oxygen or nitrogen atoms. In certain embodiments, the lipophilic moiety is an aliphatic, cyclic, cycloaliphatic, polycyclic, aromatic or polyalicyclic compound. In certain embodiments, the lipophilic moiety is a steroid (eg, sterol). Steroids include, but are not limited to, bile acids (eg, cholic acid, deoxycholic acid, and deoxycholic acid), corticosterone, digitonin, testosterone, cholesterol, and cationic steroids (such as corticosterone) .

Certain lipophilic conjugate groups and conjugate moieties have been previously described, for example, in the following references: Cholesterol moieties (Letsinger et al., Proc. Natl. Acad. Sci. USA (1989) 86:6553-6), Bile acid moiety (Manoharan et al., Bioorg. Med. Chem. Lett. (1994) 4:1053-60), thiocholesterol moiety (Oberhauser et al., Nucl. Acids Res. (1992) 20:533-8), lipid Chains, for example, dodecanediol or undecyl residues (Saison-Behmoaras et al., EMBO J. (1991) 10:1111-8; Kabanov et al., FEBS Lett. (1990) 259:327-30 ; Svinarchuk et al., Biochimie (1993) 75:49-54), palmitoyl moiety (Mishra et al., Biochim. Biophys. Acta (1995) 1264:229-37), or octadecylamine or hexylamino-5 Carbonyl-oxycholesterol moieties (Crooke et al., J Pharmacol. Exp. Ther. (1996) 277:923-37). D. Exemplary Antisense Oligonucleotide Compounds

Certain abbreviations are used in this disclosure to describe modifications of each of the nucleotides and internucleoside linkages of the ASOs described herein, which are modified oligonucleotides. The abbreviations are as follows: A is adenine nucleobase; G is guanine nucleobase; T is thymine nucleobase; mC is 5-methylcytosine nucleobase; e is 2'-MOE modified sugar; d It is 2'-deoxyribose; l is locked nucleic acid; b is bridging nucleic acid; o is phosphodiester internucleoside linkage; and s is phosphorothioate internucleoside linkage.

In certain embodiments, the ASO of the present invention is a spacer. The term "gapmer" as used in the present invention refers to an oligonucleotide comprising or consisting of an inner region located between two outer regions, wherein the sugar moiety of the nucleoside comprising the inner region is chemically different from the sugar moiety of the nucleoside comprising the external region. The term "gap" refers to the internal regions of the oligonucleotide, and the term "wing" refers to the external regions. The spacer has a 5'-flank, a gap and a 3'-flank. These three regions form a continuous sequence. The sugar moieties of each of the flanking nucleosides differ from at least some of the sugar moieties of the intervening nucleosides. Unless otherwise stated, the nucleosides of the interstitial region of the ASOs of the present invention consist entirely of 2'-deoxyribonucleosides. In some embodiments, a spacer may comprise one or more modified internucleoside linkages and/or modified nucleobases, which do not necessarily follow the sugar-modified spacer pattern.

In some embodiments, the oligonucleotides of the invention comprise spacers of MOE, BNA, LNA, or DNA modifications, or any combination thereof. In some embodiments, the spacers comprise MOE, DNA, and BNA, MOE, DNA, and LNA, or BNA, DNA, and a sugar moiety modified by LNA. In certain embodiments, the internucleoside linkages between oligonucleotides are phosphodiester or phosphorothioate internucleoside linkages, or combinations thereof.

The length of the three gapmer regions can be expressed using [number of nucleosides in the 5' flank] - [number of nucleosides in the gap] - [number of nucleosides in the 3' flank]. Thus, a 4-10-4 gapmer comprises 4 linked nucleosides in each flank and 10 linked nucleosides in the gap.

In some embodiments, the ASO of the present invention is a 3-10-3 LNA spacer. The 3-10-3 LNA spacer is 16 nucleobases in length, with the central gap segment comprising ten 2'-deoxynucleosides and each of the 5' and 3' flanking segments comprising three LNA nucleosides . In some embodiments, all cytosine nucleobases throughout the 3-10-3 LNA gapmer are 5-methylcytosine. In some embodiments, all internucleoside linkages are phosphorothioate internucleoside linkages.

In some embodiments, the ASO of the invention is a 3-11-3 LNA spacer. The 3-11-3 LNA spacer is 17 nucleobases in length, with the central gap segment comprising 11 2'-deoxynucleosides and each of the 5' and 3' flanking segments comprising three LNA nucleosides . In some embodiments, all cytosine nucleobases throughout the 3-11-3 LNA gapmer are 5-methylcytosine. In some embodiments, all internucleoside linkages are phosphorothioate internucleoside linkages.

In some embodiments, the ASO of the present invention is a 4-10-4 MOE spacer. The 4-10-4 gapmer is 18 nucleobases in length, with the central gap segment comprising ten 2'-deoxynucleosides and each of the 5' and 3' flanking segments comprising four 2'-MOEs nucleosides. In some embodiments, all cytosine nucleobases throughout the 4-10-4 MOE gapmer are 5-methylcytosine. In some embodiments, all internucleoside linkages are phosphorothioate internucleoside linkages.

In some embodiments, the ASO of the present invention is a 5-10-5 MOE spacer. The 5-10-5 gapmer is 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxynucleosides and flanked by five 2'-deoxynucleosides on both the 5' and 3' ends. Flanking segment of the MOE nucleoside. In some embodiments, all cytosine nucleobases throughout the 5-10-5 MOE gapmer are 5-methylcytosine. In some embodiments, all internucleoside linkages are phosphorothioate internucleoside linkages.

In certain embodiments, the ASO of the invention is a 3LNA-2MOE-10DNA-2MOE-3LNA gapmer, wherein each of the nucleosides at positions 1, 2, 3, 18, 19, and 20 of the oligonucleotide each of which comprises an LNA modification, each of the nucleosides at positions 4, 5, 16 and 17 of the oligonucleotide comprises a 2'-MOE modification, and each of the nucleosides at positions 6 to 15 is 2'-deoxynucleosides. In some embodiments, all internucleoside linkages are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 4 and 5, 16 and 17, and 18 and 19 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 4 and 5, and 16 and 17 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the remainder of the internucleoside linkages are phosphorothioate internucleoside linkages. In some embodiments, each cytosine nucleobase is 5-methylcytosine.

In certain embodiments, the ASO of the invention is a 2BNA-3MOE-10DNA-3MOE-2BNA gapmer, wherein each of the nucleosides at positions 1, 2, 19, and 20 comprises a BNA modification, and at positions 3, Each of the nucleosides at positions 4, 5, 16, 17, and 18 contained a 2'-MOE modification, and each of the nucleosides at positions 6-15 was a 2'-deoxynucleoside. In some embodiments, the internucleoside linkages between nucleosides at positions 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 4 and 5, and 16 and 17 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the remainder of the internucleoside linkages are phosphorothioate internucleoside linkages. In some embodiments, each cytosine nucleobase is 5-methylcytosine.

In certain embodiments, the ASO of the invention is a 3BNA-2MOE-10DNA-2MOE-3BNA gapmer, wherein each of the nucleosides at positions 1, 2, 3, 18, 19, and 20 of the oligonucleotide each of which comprises a BNA modification, each of the nucleosides at positions 4, 5, 16 and 17 of the oligonucleotide comprises a 2'-MOE modification, and each of the nucleosides at positions 6 to 15 is 2'-deoxynucleosides. In some embodiments, all internucleoside linkages are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 4 and 5, 16 and 17, and 18 and 19 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 4 and 5, and 16 and 17 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the remainder of the internucleoside linkages are phosphorothioate internucleoside linkages. In some embodiments, each cytosine nucleobase is 5-methylcytosine.

In certain embodiments, the ASO of the invention is a 2LNA-3MOE-10DNA-3MOE-2LNA gapmer, wherein each of the nucleosides at positions 1, 2, 19, and 20 comprises an LNA modification, and at positions 3, 19, and 20. Each of the nucleosides at positions 4, 5, 16, 17, and 18 contained a 2'-MOE modification, and each of the nucleosides at positions 6-15 was a 2'-deoxynucleoside. In some embodiments, the internucleoside linkages between nucleosides at positions 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 4 and 5, and 16 and 17 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the internucleoside linkages between nucleosides at positions 3 and 4, 4 and 5, 16 and 17, and 17 and 18 are phosphodiester internucleoside linkages. In some embodiments, the remainder of the internucleoside linkages are phosphorothioate internucleoside linkages. In some embodiments, each cytosine nucleobase is 5-methylcytosine.

In a particular embodiment, the present invention provides the ASOs listed in the table below and described in more detail below. Table B: Representative ASOs unmodified ASO sequence 2BNA-3MOE-10DNA-3MOE-2BNA spacer compound number 3LNA-2MOE-10DNA-2MOE-3LNA Spacer Compound No. GCAGTTTCTATCCCACTCATC (SEQ ID NO: 4) 01608 (SEQ ID NO: 18) 01618 (SEQ ID NO: 32) AATAGCATCCTTCCACACCA (SEQ ID NO: 5) 01613 (SEQ ID NO: 19) 01623 (SEQ ID NO: 33) ATCACCTTCAAACCCCTTTC (SEQ ID NO: 6) 01615 (SEQ ID NO: 20) 01625 (SEQ ID NO: 34) CCGGTGCCATTACTCCCTTT (SEQ ID NO: 7) 01609 (SEQ ID NO: 21) 01619 (SEQ ID NO: 35) TTGCAGATAAACCATCCCAC (SEQ ID NO: 8) 01611 (SEQ ID NO: 22) 01621 (SEQ ID NO: 36) AGTGCCAGACCCTTTCATTA (SEQ ID NO: 9) 01614 (SEQ ID NO: 23) 01624 (SEQ ID NO: 37) CCAAGTGCCAGACCCTTTCA (SEQ ID NO: 10) 01610 (SEQ ID NO: 24) 01620 (SEQ ID NO: 38) GCAGATAAACCATCCACTT (SEQ ID NO: 11) 01612 (SEQ ID NO: 25) 01622 (SEQ ID NO: 39) GAACTGATGCCTCTACCTCC (SEQ ID NO: 12) 01790 (SEQ ID NO: 27) 01823 (SEQ ID NO: 41) ACTGAACTGATGCCTCTACC (SEQ ID NO: 13) 01791 (SEQ ID NO: 28) 01824 (SEQ ID NO: 42) TACATGGCCAGAAACCACTT (SEQ ID NO: 14) 01792 (SEQ ID NO: 29) 01825 (SEQ ID NO: 43) AAGCCAAAGCCCAAACACTAA (SEQ ID NO: 15) 01793 (SEQ ID NO: 30) 01826 (SEQ ID NO: 44) TCCAAAGGAGCACCAACCAA (SEQ ID NO: 16) 01789 (SEQ ID NO: 31) 01822 (SEQ ID NO: 45) CGGTGCCATTACTCCCTTTC (SEQ ID NO: 17) 01616 (SEQ ID NO: 26) 01626 (SEQ ID NO: 40) D.1. Representative BNA/MOE spacer compounds

In some embodiments, the ASOs of the present invention are BNA/MOE spacer compounds (eg, the compounds described below).

Compound SNCA_ASO_01608 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence GCAGTTCTATCCCACTCATC (unmodified oligonucleotide SEQ ID NO: 4) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01608 is characterized by the following chemical notation: Gbs mCbs Aeo Geo Tes Tds mCds Tds Ads Tds mCds mCds mCds Ads mCds Teo mCeo Aes Tbs mCb (modified oligonucleotide SEQ ID NO: 18), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(VI) Compound SNCA_ASO_01608 is characterized by the following chemical structure (VI):

(VI)

Compound SNCA_ASO_01613 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence AATAGCATCCTTCCACACCA (unmodified oligonucleotide SEQ ID NO: 5) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01613 is characterized by the following chemical notation: Abs Abs Teo Aeo Ges mCds Ads Tds mCds mCds Tds Tds mCds mCds Ads mCeo Aeo mCes mCbs Ab (modified oligonucleotide SEQ ID NO: 19), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(VII) Compound SNCA_ASO_01613 is characterized by the following chemical structure (VII):

(VII)

Compound SNCA_ASO_01615 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence ATCACCTTCAAACCCCCTTTC (unmodified oligonucleotide SEQ ID NO: 6) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01615 is characterized by the following chemical notation: Abs Tbs mCeo Aeo mCes mCds Tds Tds mCds Ads Ads Ads mCds mCds mCds mCeo Teo Tes Tbs mCb (modified oligonucleotide SEQ ID NO: 20), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(VIII) Compound SNCA_ASO_01615 is characterized by the following chemical structure (VIII):

(VIII)

Compound SNCA_ASO_01609 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA gapmer having the sequence CCGGTGCCATTACTCCCTTT (unmodified oligonucleotide SEQ ID NO: 7) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01609 is characterized by the following chemical notation: mCbs mCbs Geo Geo Tes Gds mCds mCds Ads Tds Tds Ads mCds Tds mCds mCeo mCeo Tes Tbs Tb (modified oligonucleotide SEQ ID NO: 21), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(IX) Compound SNCA_ASO_01609 is characterized by the following chemical structure (IX):

(IX)

Compound SNCA_ASO_01611 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence TTGCAGATAAACCATCCCAC (unmodified oligonucleotide SEQ ID NO: 8) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01611 is characterized by the following chemical notation: Tbs Tbs Geo mCeo Aes Gds Ads Tds Ads Ads Ads mCds mCds Ads Tds mCeo mCeo mCes Abs mCb (modified oligonucleotide SEQ ID NO: 22), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(X) Compound SNCA_ASO_01611 is characterized by the following chemical structure (X):

(X)

Compound SNCA_ASO_01614 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence AGTGCCAGACCCTTTCATTA (unmodified oligonucleotide SEQ ID NO: 9) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01614 is characterized by the following chemical notation: Abs Gbs Teo Geo mCes mCds Ads Gds Ads mCds mCds mCds Tds Tds Tds mCeo Aeo Tes Tbs Ab (modified oligonucleotide SEQ ID NO: 23), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XI) Compound SNCA_ASO_01614 is characterized by the following chemical structure (XI):

(XI)

Compound SNCA_ASO_01610 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence CCAAGTGCCAGACCCTTTCA (unmodified oligonucleotide SEQ ID NO: 10) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01610 is characterized by the following chemical notation: mCbs mCbs Aeo Aeo Ges Tds Gds mCds mCds Ads Gds Ads mCds mCds mCds Teo Teo Tes mCbs Ab (modified oligonucleotide SEQ ID NO: 24), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XII) Compound SNCA_ASO_01610 is characterized by the following chemical structure (XII):

(XII)

Compound SNCA_ASO_01612 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence GCAGATAAACCATCCACTT (unmodified oligonucleotide SEQ ID NO: 11) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01612 is characterized by the following chemical notation: Gbs mCbs Aeo Geo Aes Tds Ads Ads Ads mCds mCds Ads Tds mCds mCds mCeo Aeo mCes Tbs Tb (modified oligonucleotide SEQ ID NO: 25), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XIII) Compound SNCA_ASO_01612 is characterized by the following chemical structure (XIII):

(XIII)

Compound SNCA_ASO_01616 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence CGGTGCCATTACTCCCCTTTC (unmodified oligonucleotide SEQ ID NO: 17) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01616 is characterized by the following chemical notation: mCbs Gbs Geo Teo Ges mCds mCds Ads Tds Tds Ads mCds Tds mCds mCds mCeo Teo Tes Tbs mCb (modified oligonucleotide SEQ ID NO: 26), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XIV) Compound SNCA_ASO_01616 is characterized by the following chemical structure (XIV):

(XIV)

Compound SNCA_ASO_01790 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA gapmer having the sequence GAACTGATGCCTCTACCTCC (unmodified oligonucleotide SEQ ID NO: 12) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01790 is characterized by the following chemical notation: Gbs Abs Aeo mCeo Tes Gds Ads Tds Gds mCds mCds Tds mCds Tds Ads mCeo mCeo Tes mCbs mCb (modified oligonucleotide SEQ ID NO: 27), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XV) Compound SNCA_ASO_01790 is characterized by the following chemical structure (XV):

(XV)

Compound SNCA_ASO_01791 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer, which has the sequence ACTGAACTGATGCCTCTACC (unmodified oligonucleotide SEQ ID NO: 23) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01791 is characterized by the following chemical notation: Abs mCbs Teo Geo Aes Ads mCds Tds Gds Ads Tds Gds mCds mCds Tds mCeo Teo Aes mCbs mCb (modified oligonucleotide SEQ ID NO: 28), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XVI) Compound SNCA_ASO_01791 is characterized by the following chemical structure (XVI):

(XVI)

Compound SNCA_ASO_01792 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence TACATGGCCAGAAACCACTT (unmodified oligonucleotide SEQ ID NO: 14) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01792 is characterized by the following chemical notation: Tbs Abs mCeo Aeo Tes Gds Gds mCds mCds Ads Gds Ads Ads Ads Ads mCds mCeo Aeo mCes Tbs Tb (modified oligonucleotide SEQ ID NO: 29), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XVII) Compound SNCA_ASO_01792 is characterized by the following chemical structure (XVII):

(XVII)

Compound SNCA_ASO_01793 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence AAGCCAAAGCCCAAACACTAA (unmodified oligonucleotide SEQ ID NO: 15) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01793 is characterized by the following chemical notation: Abs Abs Geo mCeo mCes Ads Ads Gds mCds mCds mCds Ads Ads Ads Ads mCds Aeo mCeo Tes Abs Ab (modified oligonucleotide SEQ ID NO: 30), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XVIII) Compound SNCA_ASO_01793 is characterized by the following chemical structure (XVIII):

(XVIII)

Compound SNCA_ASO_01789 is described as a 2BNA-3MOE-10DNA-3MOE-2BNA spacer having the sequence TCCAAAGGAGCACCAACCAA (unmodified oligonucleotide SEQ ID NO: 16) from 5' to 3', wherein nucleosides 1 to 2 and 19 Each of nucleosides 3 to 5 and 16 to 18 contains a BNA modification, each of nucleosides 3 to 5 and 16 to 18 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 3 to 4, 4 to 5, 16 to 17, and 17 to 18 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01789 is characterized by the following chemical notation: Tbs mCbs mCeo Aes Aes Ads Gds Gds Ads Gds mCds Ads mCds mCds Ads Aeo mCeo mCes Abs Ab (modified oligonucleotide SEQ ID NO: 31), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, b It is a bridging nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XIX) D.2.代表性LNA/MOE間隔體化合物 Compound SNCA_ASO_01789 is characterized by the following chemical structure (XIX):

(XIX) D.2. Representative LNA/MOE Spacer Compounds

In some embodiments, the ASOs of the present invention are LNA/MOE spacer compounds (eg, the compounds described below).

Compound SNCA_ASO_01618 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence GCAGTTCTATCCCACTCATC (unmodified oligonucleotide SEQ ID NO: 4) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01618 is characterized by the following chemical notation: Gls mClo Als Geo Tes Tds mCds Tds Ads Tds mCds mCds mCds Ads mCds Teo mCes Alo Tls mCl (modified oligonucleotide SEQ ID NO: 32), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XX) Compound SNCA_ASO_01618 is characterized by the following chemical structure (XX):

(XX)

Compound SNCA_ASO_01623 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence AATAGCATCCTTCCACACCA (unmodified oligonucleotide SEQ ID NO: 5) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01623 is characterized by the following chemical notation: Als Alo Tls Aeo Ges mCds Ads Tds mCds mCds Tds Tds mCds mCds Ads mCeo Aes mClo mCls Al (modified oligonucleotide SEQ ID NO: 33), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXI) Compound SNCA_ASO_01623 is characterized by the following chemical structure (XXI):

(XXI)

Compound SNCA_ASO_01625 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence ATCACCTTCAAACCCCCTTTC (unmodified oligonucleotide SEQ ID NO: 6) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01625 is characterized by the following chemical notation: Als Tlo mCls Aeo mCes mCds Tds Tds mCds Ads Ads Ads mCds mCds mCds mCeo Tes Tlo Tls mCl (modified oligonucleotide SEQ ID NO: 34), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXII) Compound SNCA_ASO_01625 is characterized by the following chemical structure (XXII):

(XXII)

Compound SNCA_ASO_01619 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence CCGGTGCCATTACTCCCTTT (unmodified oligonucleotide SEQ ID NO: 7) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01619 is characterized by the following chemical notation: mCls mClo Gls Geo Tes Gds mCds mCds Ads Tds Tds Ads mCds Tds mCds mCeo mCes Tlo Tls Tl (modified oligonucleotide SEQ ID NO: 35), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXIII) Compound SNCA_ASO_01619 is characterized by the following chemical structure (XXIII):

(XXIII)

Compound SNCA_ASO_01621 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence TTGCAGATAAACCATCCCAC (unmodified oligonucleotide SEQ ID NO: 8) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01621 is characterized by the following chemical notation: Tls Tlo Gls mCeo Aes Gds Ads Tds Ads Ads Ads mCds mCds Ads Tds mCeo mCes mClo Als mCl (modified oligonucleotide SEQ ID NO: 36), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXIV) Compound SNCA_ASO_01621 is characterized by the following chemical structure (XXIV):

(XXIV)

Compound SNCA_ASO_01624 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence AGTGCCAGACCCTTTCATTA (unmodified oligonucleotide SEQ ID NO: 9) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01624 is characterized by the following chemical notation: Als Glo Tls Geo mCes mCds Ads Gds Ads mCds mCds mCds Tds Tds Tds mCeo Aes Tlo Tls Al (modified oligonucleotide SEQ ID NO: 37), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXV) Compound SNCA_ASO_01624 is characterized by the following chemical structure (XXV):

(XXV)

Compound SNCA_ASO_01620 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence CCAAGTGCCAGACCCTTTCA (unmodified oligonucleotide SEQ ID NO: 10) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01620 is characterized by the following chemical notation: mCls mClo Als Aeo Ges Tds Gds mCds mCds Ads Gds Ads mCds mCds mCds Teo Tes Tlo mCls Al (modified oligonucleotide SEQ ID NO: 38), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXVI) Compound SNCA_ASO_01620 is characterized by the following chemical structure (XXVI):

(XXVI)

Compound SNCA_ASO_01622 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence GCAGATAAACCATCCCACTT (unmodified oligonucleotide SEQ ID NO: 11) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01622 is characterized by the following chemical notation: Gls mClo Als Geo Aes Tds Ads Ads Ads Ads mCds mCds Ads Tds mCds mCds mCeo Aes mClo Tls Tl (modified oligonucleotide SEQ ID NO: 39), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXVII) Compound SNCA_ASO_01622 is characterized by the following chemical structure (XXVII):

(XXVII)

Compound SNCA_ASO_01626 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence CGGTGCCATTACTCCCCTTTC (unmodified oligonucleotide SEQ ID NO: 17) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01626 is characterized by the following chemical notation: mCls Glo Gls Teo Ges mCds mCds Ads Tds Tds Ads mCds Tds mCds mCds mCeo Tes Tlo Tls mCl (modified oligonucleotide SEQ ID NO: 40), where A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXVIII) Compound SNCA_ASO_01626 is characterized by the following chemical structure (XXVIII):

(XXVIII)

Compound SNCA_ASO_01823 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence GAACTGATGCCTCTACCTCC (unmodified oligonucleotide SEQ ID NO: 12) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01823 is characterized by the following chemical notation: Gls Alo Als mCeo Tes Gds Ads Tds Gds mCds mCds Tds mCds Tds Ads mCeo mCes Tlo mCls mCl (modified oligonucleotide SEQ ID NO: 41), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXIX) Compound SNCA_ASO_01823 is characterized by the following chemical structure (XXIX):

(XXIX)

Compound SNCA_ASO_01824 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer, which has the sequence ACTGAACTGATGCCTCTACC (unmodified oligonucleotide SEQ ID NO: 13) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01824 is characterized by the following chemical notation: Als mClo Tls Geo Aes Ads mCds Tds Gds Ads Tds Gds mCds mCds Tds mCeo Tes Alo mCls mCl (modified oligonucleotide SEQ ID NO: 42), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXX) Compound SNCA_ASO_01824 is characterized by the following chemical structure (XXX):

(XXX)

Compound SNCA_ASO_01825 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence TACATGGCCAGAAACCACTT (unmodified oligonucleotide SEQ ID NO: 14) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01825 is characterized by the following chemical notation: Tls Alo mCls Aeo Tes Gds Gds mCds mCds Ads Gds Ads Ads Ads mCds mCeo Aes mClo Tls Tl (modified oligonucleotide SEQ ID NO: 43), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXXI) Compound SNCA_ASO_01825 is characterized by the following chemical structure (XXXI):

(XXXI)

Compound SNCA_ASO_01826 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence AAGCCAAAGCCCAAACACTAA (unmodified oligonucleotide SEQ ID NO: 15) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01826 is characterized by the following chemical notation: Als Alo Gls mCeo mCes Ads Ads Ads Gds mCds mCds mCds Ads Ads Ads Ads mCds Aeo mCes Tlo Als Al (modified oligonucleotide SEQ ID NO: 44), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXXII) Compound SNCA_ASO_01826 is characterized by the following chemical structure (XXXII):

(XXXII)

Compound SNCA_ASO_01822 is described as a 3LNA-2MOE-10DNA-2MOE-3LNA spacer having the sequence TCCAAAGGAGCACCAACCAA (unmodified oligonucleotide SEQ ID NO: 16) from 5' to 3', wherein nucleosides 1 to 3 and 18 Each of nucleosides 4 to 5 and 16 to 17 contains a 2'-MOE modification, each of nucleosides 6 to 15 is a 2'-deoxynucleoside, nucleoside 2 to 3, 4 to 5, 16 to 17, and 18 to 19 link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each Pyrimidine is 5-methylcytosine.

Compound SNCA_ASO_01822 is characterized by the following chemical notation: Tls mClo mCls Aeo Aes Ads Gds Gds Ads Gds mCds Ads mCds mCds Ads Aeo mCes mClo Als Al (modified oligonucleotide SEQ ID NO: 45), wherein A is an adenine nucleus Base, mC is 5-methylcytosine nucleobase, G is guanine nucleobase, T is thymine nucleobase, e is 2'-MOE modified sugar, d is 2'-deoxyribose, l It is a locked nucleic acid, o is a phosphodiester internucleoside linkage, and s is a phosphorothioate internucleoside linkage.

(XXXIII) III. 製造反義寡核苷酸之方法 Compound SNCA_ASO_01822 is characterized by the following chemical structure (XXXIII):

(XXXIII) III. Method for producing antisense oligonucleotides

Antisense oligonucleotides of the invention can be synthesized by any method known in the art. For example, an ASO can be transcribed and purified in vitro (e.g., using a commercially available in vitro RNA synthesis kit), by transcription and purification from a cell (e.g., a cell comprising an expression cassette/vector encoding the ASO), by Synthesized using an automated solid phase synthesizer, and the like. In solid phase oligonucleotide synthesis, monomeric nucleoside units are repeatedly added to a growing oligonucleotide chain covalently bound to a support. In the case of phosphodiester linkages, electrophilic 3' phosphoramidite monomer units can be used. However, any suitable electrophilic group can be used to covalently link the two nucleosides.

The ASO of the present invention can be purified by any method known in the art following solid phase synthesis. For example, oligonucleotides can be precipitated from a solution by treating the solution with ethanol and divalent cations. The ASO of the present invention can also be purified using, for example, size fractionation columns, reverse phase chromatography, high performance liquid chromatography, and polyacrylamide gel electrophoresis.

Exemplary methods for synthesizing antisense oligonucleotides using solid supports and purifying the oligonucleotides are described, for example, in Ellington et al., Introduction to the synthesis and purification of oligonucleotides. Curr. Protoc. Nucleic Acid Chem. (2001) in Appendix 3C. IV. Compositions of antisense oligonucleotides

In some embodiments, the invention relates to compositions (eg, pharmaceutical compositions) comprising the ASOs described herein. In some embodiments, the composition is useful for treating a disease or disorder associated with the expression or overexpression of α-synuclein (eg, a synucleinopathy). Compositions of the invention can be formulated based on the mode of delivery.

The pharmaceutical compositions described herein may comprise pharmaceutically acceptable excipients. Pharmaceutically acceptable excipients can be liquid or solid, and can be selected with the intended mode of administration in mind so as to provide the desired volume, viscosity, and other relevant transport and chemical properties. Any known pharmaceutically acceptable carrier or diluent can be used, including, for example, water, saline solution, buffers, preservatives, and the like. For example, an ASO of the invention can be administered to a patient in the form of a formulation in phosphate buffered saline (PBS). Examples of pharmaceutically acceptable excipients include water, saline, buffered solutions or artificial cerebrospinal fluid. The pharmaceutically acceptable excipient is preferably sterile.

The ASOs of the present invention can be administered in the form of pharmaceutically acceptable salts. Pharmaceutically acceptable salts are salts of the ASO of the present invention that are physiologically acceptable and retain the desired biological activity of the ASO without undesired toxicological effects. As used herein, the term ASO includes both the free acid form and the salt form (eg, the sodium salt form) of the oligonucleotide.

ASOs of the invention can be mixed, encapsulated (eg, encapsulated in lipid nanoparticles), bound or otherwise associated with other molecules, molecular structures or nucleic acid mixtures.

US Patent Publication No. 2020/0385723 provides pharmaceutical compositions suitable for use with the ASOs of the present invention. V. Methods of using antisense oligonucleotides

The ASOs of the invention generally inhibit the activity of the transcript encoded by the SNCA gene in mammalian cells, such as human cells. In some embodiments, the cell line is a neuronal cell. In certain embodiments, the cell line is a cell of the central nervous system (CNS), including cells of the following: motor cortex, frontal cortex, caudate, amygdala, pons, substantia nigra, putamen, peduncle , corpus callosum, dorsal cochlear nerve (DCN), entorhinal cortex (Ent Cortex), hippocampus, insular cortex, medulla oblongata, central gray matter, pulvinus thalamus, occipital cortex, cerebral cortex, temporal cortex, globus pallidum, superior Colliculus and basal forebrain nucleus.

The present invention provides methods for down-regulating the abundance or activity of SNCA gene transcripts in cells or in tissues comprising contacting the cells or tissues with an effective amount of one or more of the ASOs or compositions of the present invention. These methods can be performed in vitro or in vivo.

In some embodiments, ASO of the present invention can be used for treatment or prevention. The ASOs of the present invention can be used as therapeutic agents in animals suspected of suffering from diseases or disorders that can be treated by modulating the expression of SNCA gene transcripts and/or α-synuclein. The animal may also be predisposed to, and not necessarily suspected of having, a disease or disorder associated with expression of the SNCA gene. The animal is treated by administering a therapeutically or prophylactically effective amount of one or more of the ASO compounds or pharmaceutical compositions of the invention. In some embodiments, the animal is a mammal. In some embodiments, the animal is human.

In some embodiments, the ASOs described herein can be used to treat neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, diffuse Lewy body disease, isolated autonomic failure, multiple system atrophy, neuronal hypertrophy Che's disease (neuronopathic Gaucher's disease), and Alzheimer's disease. In general, neurodegenerative diseases result in the death of neurons.

In some embodiments, the ASOs of the invention ameliorate the symptoms of a disease or condition associated with the expression of the SNCA gene. Improvement can refer to a reduction in the severity or frequency of symptoms. Improvement can also refer to a delay in the onset or progression of symptoms. In some embodiments, the symptom alleviated by treatment with the ASO is motor dysfunction, aggregation of alpha-synuclein, neurodegeneration, cognitive decline, or dementia. Improvement of these symptoms can result in improved motor function, reduction in alpha-synuclein aggregation, reduced neurodegeneration, reduced or reversed cognitive decline, and/or reduced or reversed dementia.

A "therapeutically effective amount" of an ASO as disclosed herein is an amount sufficient to perform a stated purpose. This amount can be determined empirically and routinely for the purposes set forth herein. Certain factors can affect the dosage and timing required to effectively treat an individual, including, but not limited to, the severity of the disease or disorder, previous therapy, the general health and/or age of the individual, and the presence of one or more other diseases. Furthermore, treatment of an individual with a therapeutically effective amount of a pharmaceutical composition may comprise a single treatment or a series of treatments. The effective dose and in vivo half-life of the ASO of the present invention can be evaluated using known methods or based on in vivo tests using appropriate animal models. A therapeutically effective amount reduces the symptoms of the disease.

In certain embodiments, an ASO or pharmaceutical composition of the invention is prepared for injection (eg, intravenous, subcutaneous, intramuscular, intrathecal (IT), intracerebroventricular (ICV), intracranial, and the like). In preferred embodiments, the pharmaceutical composition is injected intrathecally or intracranially into the subject.

In some embodiments, the ASOs of the invention can be used for research purposes. For example, ASO can be used to specifically inhibit the synthesis of α-synuclein in cells and experimental animals. ASO-mediated inhibition of α-synuclein synthesis can be used for functional analysis of α-synuclein. VI. Kits and products

The invention also provides kits and articles of manufacture comprising the ASOs described herein. A kit or article comprising an ASO of the invention can be used to perform the methods described herein. The kit or article comprises at least one ASO in one or more containers.

In some embodiments, the kits or articles of manufacture described herein can be used to treat and/or prevent diseases associated with the expression of SNCA genes (eg, synucleinopathies). The kit or article may further comprise a container and a label or package insert on or associated with the container. Suitable containers include, for example, bottles, vials, syringes, IV bags, and the like. The containers can be made of various materials, such as glass or plastic, and can contain the composition itself or in combination with another composition effective for treating or preventing the disease, and can have a sterile access port (such as the container It may be an IV bag or a vial with a stopper penetrated by a hypodermic needle). The kit or article of manufacture may further comprise a package insert indicating that the compositions may be used to treat a particular disease. Alternatively or additionally, the article or kit may further comprise a second (or third) container comprising a pharmaceutically acceptable buffer such as bacteriostatic water for injection (BWFI), phosphate buffered saline, Ringer's solution and dextrose solution. It may further include other materials as may be desired from a commercial and/or user standpoint, including other buffers, diluents, filters, needles and syringes.

In some embodiments, a kit contains all components necessary and/or sufficient to perform a detection assay, including all controls, instructions for performing the assay, and any necessary software for analysis and presentation of results. Those skilled in the art will readily recognize that the ASO disclosed herein can be readily incorporated into one of the established kit formats well known in the art.

Unless otherwise defined herein, scientific and technical terms used in connection with the present invention shall have the meanings commonly understood by those of ordinary skill in the art. Exemplary methods and materials are described below, however methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention. In case of conflict, the present specification, including definitions, will control. Generally, nomenclature and techniques related to neurology, medicine, pharmaceutical and medicinal chemistry, and cell biology are described herein that are well known and commonly used in the art. Enzymatic reactions and purification techniques are performed according to manufacturer's specifications, as commonly performed in the art or as described herein. Further, unless the context requires otherwise, terms in the singular shall include the plural and terms in the plural shall include the singular. Throughout this specification and examples, the words "have" and "comprise", or variations such as "has", "having", "comprises" will be understood ” or “comprising” implies the inclusion of a specified integer or group of integers, but does not exclude any other integer or group of integers. As used herein, the term "about" or "approximately" when applied to a value or values of interest refers to a value that is similar to a stated reference value. In certain embodiments, unless otherwise stated or apparent from the context, the term refers to the term falling within 10%, 9%, 8%, 7%, A range of values within 6%, 5%, 4%, 3%, 2%, 1% or less.

All publications and other references mentioned herein are incorporated by reference in their entirety. Although a number of documents are cited herein, this citation does not constitute an admission that any of these documents form part of the common general knowledge in the art.

For a better understanding of the invention, the following examples are set forth. These examples are for illustration purposes only and should not be construed as limiting the scope of the invention in any way. example

Materials and methods used in the experiments described below are as follows. Construction of ASO

The ASO was constructed to be complementary to the sense strand of the gene body SNCA sequence (SEQ ID NO: 1) and the sequence of the mRNA transcribed from the SNCA gene (NC_000004.12::89724099..89838324, SEQ ID NO: 2). Sk-Mel-2 cell culture

Sk-Mel-2 cells were cultured in Eagle's minimal essential medium (EMEM) supplemented with 10% fetal bovine serum (FBS). Transgenic human SNCA mice and neuronal collection

C57BL/6Tac mice (Taconic) were genetically engineered to introduce the entire wild-type human SNCA gene starting from its 5'UTR (SEQ ID NO: 1) into the mouse gene in vivo instead of the mouse SNCA gene and in the mouse SNCA promoter under the control. C57BL/6Tac mice (Taconic) were genetically engineered to replace the mouse SNCA gene with the entire human SNCA gene mutated in position A53T starting from its 5' UTR (SEQ ID NO: 1 ) into the mouse genome in vivo. under the control of the mouse SNCA promoter. At embryonic day 17.5, primary cortical neurons were collected from embryos removed from pregnant homozygous human SNCA- inserted mice. Cortical tissue from each embryo was dissected on ice-cold Hank's balanced salt solution. Pooled tissues were minced and digested with papain at 37°C for 12 minutes. Digestion was then stopped by adding 10% FBS/DMEM. The cells were triturated and resuspended in Neurobasal ^™ Plus Medium supplemented with GlutaMAX ^™ , 2% Penicillin/Streptomycin and B-27 ^™ Plus Supplement. Cells were seeded at a density of 15000 cells/well in 40 µL of supplemented Neurobasal ^™ medium (containing B-27 ^™ supplement and GlutaMAX) on poly-L-lysine+boronic acid coated 384-well plates. Neurons were then cultured for four days at 37°C in a 5% _CO2 atmosphere. Male Winstar rats

Male Wistar rats weighed 200 to 225 g on arrival and were housed in groups of two per cage at room temperature with ad libitum access to food and water. All procedures were approved by the Institut de Recherches SERVIER ethical committee in accordance with the principles of the Guide to the Care and Use of Experimental Animals. ASO screening in neurons in vitro

For single-dose screens, neurons were treated with 300 nM of the indicated ASO. For multiple dose screening, neurons were treated with serial dilutions of the indicated ASO starting at 3 µM (½ log dilution, 11 concentrations total). Seven days after treatment with the ASO, the medium was replaced with new Neurobasal ^™ medium. After 15 days of treatment, RNA was extracted from the cells using TaqMan ^™ Fast Advanced Cells-to-CT kit (ThermoFisher). Cells were then washed in PBS and lysed in solution for five minutes at room temperature while undergoing DNase treatment. Lysis was terminated by treating the mixture with stop solution, followed by incubation for two minutes at room temperature. Immediately after cell lysis, reverse transcription was performed using Fast Advanced RT Enzyme Mix (ThermoFisher). The cDNA samples were then used for quantitative real-time PCR measurements using TaqMan ^™ genotyping assays. Specific probes and primers were used for SNCA mRNA quantification (Hs00240906_m1 SNCA; ThermoFisher). The amount of SNCA mRNA was adjusted to that of the housekeeping gene PPIA (probe/primer PPIA_Mm02342430_g1; ThermoFisher).

In qPCR reactions, the quantitative cycle value (Ct) is defined as the number of cycles required for the fluorescence signal to exceed the background fluorescence. The QuantStudio ^™ real-time PCR software program (Applied Biosystems, Foster City, CA) set this cutoff at ten standard deviations above the mean baseline fluorescence. The comparative Ct method normalizes the Ct values of target genes to housekeeping genes, which are then compared between samples. First, the difference between the Ct values of the target gene and the housekeeping gene (ΔCt) is calculated for each sample, and then the difference in the ΔCt (ΔΔCt) is calculated between two samples (eg, control and treatment). The fold change in expression of the two samples was calculated as 2 ^{- ΔΔCt} . The percent reduction was calculated by subtracting the 2 ^-ΔΔCt of the ASO group mean of interest from the value 1 and multiplying by 100, % reduction (1- 2-ΔΔCt ASO group mean) × 100. mouse model

As shown in Figure 1, the entire wild-type (WT) human SNCA gene (SEQ ID NO: 1) was introduced into the mouse gene vivo to replace the mouse SNCA locus in C57BL/6Tac mice (Taconic). The expression of human and murine SNCA proteins in different brain regions and peripheral organs was analyzed by mass spectrometry analysis ( FIGS. 2A to 2C ). Three- to four-month-old homozygous male mice expressing the WT human SNCA gene (referred to as " hSNCA ^+/+ KI mice" or " hSNCA mice") were housed in groups of up to three animals per cage at room temperature Housed with free access to food and water. All procedures were approved by the Institute Servier Ethics Committee in accordance with the principles of the Guide for the Care and Use of Laboratory Animals. hSNCA A53T neurons

As depicted in Figure 1, the entire human A53T SNCA gene was introduced into the mouse gene body to replace the mouse SNCA locus of C57BL/6Tac mice (Taconic). Homozygous female mice expressing the human A53T SNCA gene (designated hA53TSNCA ^+/+ KI) were housed separately, one animal per cage, at room temperature with food and water ad libitum. All procedures were approved by the Institute Servier Ethics Committee in accordance with the principles of the Guide for the Care and Use of Laboratory Animals. Intraventricular (ICV) injection

Use sterile saline syringes and nuclease-free centrifuge tubes to prepare dosing solutions. The tube containing the ASO powder was centrifuged briefly, then saline solution was added, followed by re-centrifugation for 10 minutes to completely dissolve the ASO powder. The solution was vortexed for approximately one minute and stored at 4°C until use.

hSNCA mice received a single unilateral bolus injection of oligonucleotides at a dose of 30 nmol. Mice were anesthetized with 4.5 to 5% isoflurane and maintained with 1.5 to 2% isoflurane during surgery. For pain management, buprenorphine was administered subcutaneously at a dose of 0.04 mg/kg at least 30 minutes prior to injection. The mice were shaved, and after loss of the plantar reflex, the mice were placed in a stereotaxic stand (David Kopf Instruments, CA). The scalp was sterilized using three alternating wipes of Betadine and 70% ethanol. An incision is made in the scalp and the surface of the skull is exposed and bregma is clearly identified. A hole was drilled in the skull at 0.5 mm AP, 1.1 mm ML relative to bregma. ASO was injected through a cannula (31 g) connected to a micro-syringe pump controller. The dorsal-ventral DV coordinates were measured 1 mm below the skull surface. Once the cannula is in place, the ASO solution is administered in 5 µL of saline vehicle over 30 seconds. The cannula was left in place for an additional three minutes after injection to allow the solution to diffuse in the brain. After the cannula was slowly withdrawn, the scalp was sutured and the mice were injected subcutaneously with 1 mL of warm sterile saline solution to help rehydrate and placed in a warm home cage. Control mice were similarly administered a saline vehicle control. Mice were observed until they regained consciousness and mobility to prevent potential adverse behavioral effects. Drug tolerance was scored one hour after dosing. Animals dosed with non-tolerant compound (tolerance score > 8) were euthanized immediately after the one-hour assessment.

The antisense oligonucleotides described above were tested in hSNCA ^+/+ KI (insertion) mice as described above to assess their tolerance profile. ASO SNCA_00033 as previously described in PCT Patent Publication WO 2012/068405 was also tested as a comparator. In all cases, ASO SNCA_00033 has a 5-10-5 MOE gapmer pattern in which all internucleoside linkages are phosphorothioate internucleoside linkages and all cytosine residues are 5-methylcytosine . Intrathecal (IT) injection

Male Wistar rats received a single intrathecal bolus injection of oligonucleotide at a dose of 2.5 mg. Rats were anesthetized with 4% isoflurane and maintained with 2 to 2.5% isoflurane during surgery. For pain management, Carprofene 5 mg/kg and Buprenorphine 0.05 mg/kg were administered subcutaneously for at least 20 minutes prior to injection. Rats were shaved and an incision was made between the 5th and 6th lumbar vertebrae after loss of the plantar reflex. The muscles surrounding this area were dissected to allow insertion of the spinal canal into a catheter for ASO injection. Once the catheter is in place, ASO solution is administered in 30 μl of artificial CSF over ~30 seconds. The catheter was left in place and sealed to prevent CSF fluid from spreading. Muscle and skin were sutured, and the rats were injected subcutaneously with 1 mL of warm sterile saline to help rehydrate and placed in warm home cages. Rats in the control group were also given artificial CSF. Rats were observed until they regained consciousness and mobility to prevent potential adverse behavioral effects. Drug tolerance was scored at one, three and 24 hours after administration. Animals dosed with non-tolerant compound (tolerance score > 8) were euthanized immediately after the one-hour assessment. ASO Acute Tolerance Assessment

Adverse reactions in the administered mice were monitored and scored according to the criteria shown in FIG. 3 at one and three hours after injection. Adverse reactions in the dosed rats were monitored and scored according to the criteria shown in FIG. 10 at one, three and twenty-four hours after injection. The normal tolerability score is 0 and the acute toxicity score corresponds to 16. The final tolerability score was calculated based on the sum of all criteria. For some oligonucleotides, intolerable acute toxicity was observed without reaching the first observed time point. In these cases, the ASO acute toxicity score was scored 14 and the mice were immediately euthanized. Mice were closely monitored throughout the experiment if a score above 6 was measured at the one hour time point. ASO long-term tolerability assessment

Mice were weighed on the day of injection and three times a week until the completion of the experiment. Any mice showing intolerable health, behavioral observations, or weight loss of more than 20% of their starting body weight were immediately euthanized. tissue sampling

All mice were euthanized by anesthetic overdose. Animals were perfused cardiacly with 0.9% saline in the left ventricle. The large thoracic artery between the lungs and liver is clamped with hemostats to block blood flow from the heart to the abdomen but to allow blood flow to the brain. Cut open the right ventricle with scissors. A constant pressure of 100 to 120 mm Hg was maintained over the perfusion solution by connecting the solution bottle to an air compressor controlled by a manometer. Perfusion was continued until the surface of the skull blanched and the perfusion solution flowed out of the right ventricle. After perfusion, brain tissue (cortex) and peripheral tissues (kidney and liver) were collected. The samples were cut into small pieces, mixed and divided into thirds. All samples were frozen with liquid nitrogen and stored at -80°C until RNA, protein and ASO measurements. For some studies, blood and cerebrospinal fluid (CSF) were also collected. mRNA measurement by qRT-PCR

RNA extraction and mRNA quantification by qPCR were performed. From right cortical biopsies, RNA was extracted using RNeasy Mini Kit (Qiagen) treated with DNase. Total RNA samples were quantified using a Nanodrop™ spectrophotometer and analyzed using a TapeStation to determine the quality of the RNA (RIN). In qPCR quantification experiments, the RNA was first reverse transcribed using a high capacity cDNA reverse transcription kit (Applied Biosystems™). The reaction was performed in a final reaction volume of 100 µL, starting with 1000 ng of total RNA (to a final RNA concentration of 10 ng/µL). Quantification of human SNCA gene and mouse PPIA housekeeping gene from 40 ng of total cDNA using QuantStudio 7 Flex (Applied Biosystems™), TaqMan ^™ Universal PCR Master Mix (Applied Biosystems™, reference 4324020) and TaqMan ^™ gene expression analysis in duplex (Hs00240906_m1 in FAM fluorescent dye and Mm02342430_g1 in VIC fluorescent dye). qPCR analysis was performed in triplicate using fast-run mode. The Ct value of each qPCR plate was analyzed using Excel software. Technical replicates (n = 3) were combined and averaged to the geometric mean. Relative expression was generated using mouse control PBS conditions for each ASO group. Analysis of hSNCA protein expression by mass spectrometry

Mouse brain tissue was homogenized using Pecellys® (2x20 s, 5000 tr) at 150 mg/mL in lysis buffer (PBS, sigma protease and phosphatase inhibitor cocktail, 1% deoxycholate). The brain homogenate was then centrifuged (27000 g, 4°C, 20 minutes) and the supernatant collected. Brain samples were diluted in denaturing buffer (ammonium bicarbonate 50 mM, deoxycholate 1%) and then heated at 95°C for five minutes. Next, trypsin (10 µg) was added to each sample. Trypsinization was performed in an ultrasonic bath (Branson 1200) for one minute, followed by incubation at 52°C for 30 minutes. The reaction was stopped by adding 1 µL TCEP (0.5 M) and 1 µL 100% formic acid, followed by incubation at 95°C for five minutes. The samples were then centrifuged at 30,000 g for 15 minutes. Peptide digests were analyzed by reverse phase liquid chromatography tandem mass spectrometry (LC-MS/MS) using a Shimadzu LC system (Shimadzu) coupled online to a triple quadrupole mass spectrometer (Shimadzu 8060) operating in MRM mode. The specific peptides used to measure the abundance of α-synuclein are TVEGAGSIAAATGFVK (SEQ ID NO: 46) and TVEGAGNIAAATGFVK (SEQ ID NO: 47). The specific peptide used to measure the abundance of GAPDH protein is VGVNGFGR (SEQ ID NO: 48). A single 10 μL injection of each brain sample digest was injected onto a Waters ^™ XBridge Peptide BEH C18 column (130 Å; 3.5 µm; 150 mm x 2.1 mm). The peptide was eluted using a linear gradient of acetonitrile (2 to 40%) in 0.1% formic acid over 30 min. Chromatograms were analyzed using Shimadzu LabSolutions software. The signal intensity obtained for each peptide was normalized to the GAPDH signal obtained in each sample and expressed in arbitrary units (AU). Expression of hSNCA protein or α-synuclein by ELISA

Mouse brain tissue was homogenized using Pecellys® (2x20 s, 5000 tr) at 150 mg/mL in lysis buffer (PBS, sigma protease and phosphatase inhibitor cocktail, 1% deoxycholate). The brain homogenate was then centrifuged (27000 g, 4°C, 20 minutes) and the supernatant collected. α-synuclein in brain lysates was quantified by using the U-PLEX Human α-synuclein Kit (K151WKK) following the manufacturer's instructions. Total α-synuclein in brain lysates was quantified using a commercial ELISA kit from MSD®, U-PLEX Human α-synuclein Kit (K151WKK). The provided assay plates were pre-coated with a capture antibody to α-synuclein. The sample (brain lysate) was added to a solution containing a detection antibody (anti-α-synuclein) conjugated to an electroluminescent compound tag (MSD SULFO-TAG). Analytes in the sample bind to capture antibodies immobilized on the surface of the working electrode. Recruitment of bound detection antibody from bound analyte completes the sandwich. MSD® Read Buffer is added to provide the appropriate chemical environment for electroluminescence and the plate is loaded into the MSD SECTOR® Imager for analysis. Inside the SECTOR imager, a voltage is applied to the plate electrodes, causing the probes bound to the electrode surface to emit light. The instrument measures the intensity of the emitted light to provide a quantitative measure of the alpha-synuclein present in the sample. High Performance Liquid Chromatography (HPLC) Fluorescence

Samples were analyzed against a set of calibration standards prepared in water. Since no matrix effects were observed, all samples (plasma, CSF, and tissue) were quantified using a set of standards in water. Frozen tissue was weighed into Masterpure ^™ /Protéinase K 97/3 (V/V) buffer and ground 2x30 sec at 6500 rpm using a Precellys apparatus. Plasma samples (5 µL) were diluted in Masterpure ^TM /ptoteinase K 97/3 (70 µL). Plasma and tissue homogenates were incubated at 55°C for 30 minutes with gentle agitation. Then, 10 µL of KCl 3M solution was added to 50 µL of tissue homogenate or plasma dilution, vortexed quickly and sonicated for five minutes. The tubes were centrifuged (20000 g) for ten minutes at +4°C. CSF samples (10 µL) were diluted in hybridization buffer (Tris HCl 50 mM pH 8.5 / ACN 90/10) (45 µL) and proteinase K (1 µL) and incubated at 55°C for 15 minutes. Prior to analysis, a hybridization step is performed with fluorescently labeled peptide nucleic acid oligomers complementary to the quantified oligonucleotides. For calibration standards and tissue homogenates, mix 40 µL of hybridization buffer with 10 µL of fluorescent complementary probes and 10 µL of calibration standards, quality control samples, and research sample supernatants. For plasma samples, mix 30 µL of hybridization buffer with 10 µL of fluorescent complementary probes and 60 µL of quality control and research sample supernatants. For CSF analysis, add 10 µL of fluorescent complementary probes directly to the previous dilution. The mixtures were first incubated at 95°C for 15 minutes and then at 55°C for 15 minutes. Finally, samples were centrifuged for 5 min at 4°C (20,000 g). The samples were analyzed under the RP-HPLC system with fluorescence detection. Injection volumes are 50 µL, except for plasma (90 µL). The amount of fluorescence resulting from hybridization of the oligonucleotide to the fluorescent probe is measured and compared to a calibration curve. The oligonucleotide concentration in the sample was calculated taking into account the different dilutions used during sample preparation. Example 1: In vitro mRNA reduction after a single dose of ASO

Modified oligonucleotides complementary to the human SNCA nucleotide sequence were designed and tested for their selective utility in reducing the amount of SNCA mRNA in cultured Sk-Mel-2 cells. Cultured Sk-Mel-2 cells were transfected with modified antisense oligonucleotides (ASO) at a concentration of 20 nM or 2 nM using Lipofectamine 2000 (Invitrogen) at a density of 15000 cells per well. After 24 hours, RNA was isolated from the cells and the amount of SNCA mRNA was measured by branched DNA assay (QuantiGene Singleplex assay kit, ThermoFisher). This method relies on signal amplification of branched DNA (bDNA) probes that bind to specific nucleotide sequences. The probe sets used were XM_005555421 (responsive to dog and human SNCA ) and NM_002046 (reactive to human GapDH ), which were designed by Affymetrix Inc./ThermoScientific and synthesized by Metabion International. SNCA -RLUs were normalized to the GapDH relative light units (RLU) of the respective wells. Values were normalized to wells treated with non-specific ( Ahsa1 ) ASO.

The modified oligonucleotides tested in the experiments above are shown in Table C below. Each modified oligonucleotide listed in Table C is complementary to the human SNCA nucleic acid sequence (SEQ ID NO: 1) and is a 5-10-5 MOE spacer. The gapmers are 20 nucleobases in length, with the central gap segment comprising ten 2'-deoxynucleosides and each of the flanking segments comprising five 2'MOE nucleosides. All cytosines throughout each gapmer were 5-methylcytosines, and all internucleoside linkages were phosphorothioate internucleoside linkages.

The positions identified in Table C correspond to the "start site", ie, the 5' nucleoside complementary to the gapmer in the human nucleic acid sequence (SEQ ID NO: 1). Table C: 5-10-5 MOE Spacers Compound name % reduction (20 nM ASO) % reduction (2 nM ASO) unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_00272 85.11 62.97 CGTAGTCTTGATACCCTTCC 49 109019 SNCA_ASO_00275 84.16 60.66 GTTCGTAGTCTTGATACCCT 50 109022 SNCA_ASO_00276 77.48 47.04 GGTTCGTAGTCTTGATACCC 51 109023 SNCA_ASO_00277 73.6 32.35 AGGTTCGTAGTCTTGATACC 52 109024 SNCA_ASO_00278 77.14 40.19 CAGGTTCGTAGTCTTGATAC 53 109025 SNCA_ASO_00280 67.22 30.48 TTCAGGTTCGTAGTCTTGAT 54 109027 SNCA_ASO_00614 81.71 69.07 GCTATGACCCTCAAGCCATC 55 28601 SNCA_ASO_00623 82.74 38.79 CAACTAACCACGGCACAATT 56 30828 SNCA_ASO_00675 81.9 80.45 TAGCCGACATACATCTCCAA 57 49733 SNCA_ASO_00838 83.79 82.2 CGGTGCCATTACTCCCTTTC 17 16400 SNCA_ASO_00839 82.04 72.12 GTAAATATGTCAGTCTCCCG 58 18540 SNCA_ASO_00840 77.2 72.64 GGGTTCTCTAACGACAGTAG 59 25550 SNCA_ASO_00841 84.07 76.25 GGGGTTCTCTAACGACAGTA 60 25551 SNCA_ASO_00842 82.59 66.98 GGATGGGGTTCTCTAACGAC 61 25555 SNCA_ASO_00843 76.65 71.55 GAGCGATCGGAAGCTCCCTG 62 27763 SNCA_ASO_00844 78.82 65.01 AGAGCGATCGGAAGCTCCCT 63 27764 SNCA_ASO_00846 87.75 83.14 GTTGCTATCTAGGGATCACC 64 29769 SNCA_ASO_00847 85.38 68.17 GCGAAGGACTATAATAGG 65 33628 SNCA_ASO_00848 74.92 79.56 GGTAACTTAGGACAAGGTCC 66 38957 SNCA_ASO_00849 82.08 75.02 TTCACATAAAGTAGCCGCTA 67 40930 SNCA_ASO_00850 81.94 77.39 ACTTCACATAAAGTAGCCGCGC 68 40932 SNCA_ASO_00852 84.48 79.71 ATAGCCGACATACATCTCCA 69 49734 SNCA_ASO_00853 68.5 72.58 GACGGATCAGACACTTCTTAC 70 52858 SNCA_ASO_00854 79.16 66.41 TGCCTCACGGATGTCCGTGT 71 59974 SNCA_ASO_00855 70.93 77.42 GCTCGAGATTAGTTCTTCCC 72 69469 SNCA_ASO_00856 80.22 66.67 GCCACTAGTAGATGACAGTT 73 71531 SNCA_ASO_00857 74.41 64.94 GATGGAATTTACCCCCTAGT 74 74726 SNCA_ASO_00858 76.66 65.96 AGCAGAAGCATGCGGCTACC 75 76062 SNCA_ASO_00859 75.83 66.3 GGTATCGTCATGGAATTTGG 76 N/A SNCA_ASO_00860 36.95 0 GATCTAAGGACCCTCAACAA 77 N/A SNCA_ASO_00861 38.54 3.53 GGATCTAAGGACCCTCAACA 78 N/A SNCA_ASO_00862 44.27 11.32 ACTCTATCTTGAGGCACACC 79 N/A SNCA_ASO_00863 51.23 20.83 CTGTTAATGTAGTAGGAGCA 80 N/A SNCA_ASO_00864 47.89 13.36 ACTGTTAATGTAGTAGGAGC 81 N/A SNCA_ASO_01573 58.1 12.31 TTTGGGGTTTACCTACCTAC 82 118 SNCA_ASO_01574 79.88 45.93 TACTGACTGTCCAAGGGTGT 83 7961 SNCA_ASO_01575 61.12 33.36 TCAGGGCAAGGGTATGCTTG 84 14181 SNCA_ASO_01576 56.77 45.29 TCCAGTCAGGTGGTGTATGA 85 15923 SNCA_ASO_01577 79.77 57.72 ATGGGGTTCTCTAACGACAG 86 25553 SNCA_ASO_01578 77.99 52.47 TGGATGGGGTTCTCTAACGA 87 25556 SNCA_ASO_01579 66.87 55.72 AAGAGCGATCGGAAGCTCCC 88 27765 SNCA_ASO_01580 67.08 47.85 TTTTCAAGAGCGATCGGAAG 89 27770 SNCA_ASO_01581 74.45 61.9 CTAGCGAAGGACTATATAAT 90 33631 SNCA_ASO_01582 80.41 29.7 CTATCTTACGTGGCTATATC 91 35367 SNCA_ASO_01583 78.91 46.37 AAGTAGCCGCTACTGCTTAA 92 40922 SNCA_ASO_01584 75.21 63.17 TCTGGACAGGCGCTTATCTA 93 41589 SNCA_ASO_01585 74.66 54.27 GATGGAGTACCTACCAACTT 94 43655 SNCA_ASO_01586 69.99 40.76 ACACGTGGCCAGATCAATCC 95 48683 SNCA_ASO_01587 68.06 41.86 CTACACACGTGGCCAGATCA 96 48687 SNCA_ASO_01588 69.37 42.92 ACTACACACGTGGCCAGATC 97 48688 SNCA_ASO_01589 67.29 51.66 TTTGGGCATGACTACACACG 98 48698 SNCA_ASO_01590 77.21 63.81 ATGGGCCATTGGCAATCAAG 99 52775 SNCA_ASO_01591 60.33 45.55 CCTGCCTCACGGATGTCCGT 100 59976 SNCA_ASO_01592 67.92 44.6 TCCTGCCTCACGGATGTCCG 101 59977 SNCA_ASO_01593 58.46 32.41 CATAAGATCGATTAAGTGGA 102 60755 SNCA_ASO_01594 61.41 42.21 ACATAAGATCGATTAAGTGG 103 60756 SNCA_ASO_01595 64.63 24.95 TACATAAGATCGATTAAGTG 104 60757 SNCA_ASO_01596 74.37 47.48 ATTAGGCCTGATTAGCTAAA 105 61840 SNCA_ASO_01597 70.46 61.73 TATCTGTAACCACGCCCTTA 106 72245 SNCA_ASO_01598 60.72 31.9 GAAGCATGCGGCTACCATGC 107 76058 SNCA_ASO_01599 68.09 45.51 AAGCAGAAAGCATGCGGCTAC 108 76063 SNCA_ASO_01600 78.89 53.15 TATAAATCTTCAGGGACTCG 109 78150 SNCA_ASO_01601 70.13 49.38 TGGTTCGATAATAGCTAAGC 110 78175 SNCA_ASO_01602 77.37 59.33 CGTCATGGAATTTGGTCTGT 111 N/A SNCA_ASO_01603 35.25 24.55 GGGATTCATCTGGCATTAGG 112 N/A SNCA_ASO_01604 67.81 30.82 ATGCTAAGCCAAACCTAGCA 113 98646 SNCA_ASO_01605 69.62 44.58 CAGTAGACCACTGATGATCT 114 98760 SNCA_ASO_01606 74.43 56.16 TAGAGTGACAGGTCTGGTAC 115 99041 SNCA_ASO_01607 51.55 23.37 GGGAGTGTGTACATAGTGTA 116 100146

Each of the modified oligonucleotides listed in Table D is complementary to the human SNCA nucleic acid sequence (SEQ ID NO: 1) and is a 4-10-4 MOE spacer. The spacer is 18 nucleobases in length, with a central gap segment comprising ten 2'-deoxynucleosides and flanking segments on both 5' and 3' ends comprising four 2'-MOE nucleosides . All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages.

The identified positions in Table D correspond to the "start site", ie, the 5' nucleoside complementary to the gapmer in the human SNCA nucleic acid sequence (SEQ ID NO: 1). Table D: 4-10-4 MOE Spacers Compound name % reduction (20 nM ASO) % reduction (2 nM ASO) unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_01528 83.87 37.6 GCCATACTAGTTATGACA 117 9579 SNCA_ASO_01529 85.7 66.86 AACCGGTGCCATTACTCC 118 16405 SNCA_ASO_01530 89.66 69.2 CTTCATATACGAGTTGAC 119 19976 SNCA_ASO_01531 72.22 30.17 GGATGGGGTTCTCTAACG 120 25557 SNCA_ASO_01532 56 0.97 GTAGTTAGGTGTAGTTG 121 27133 SNCA_ASO_01533 85.58 75.16 AGCGATCGGAAGCTCCCT 122 27764 SNCA_ASO_01534 86.63 56.47 TTTTCAAGAGCGATCGGA 123 27772 SNCA_ASO_01535 89.02 74.3 GTTTTCAAGAGCGATCGG 124 27773 SNCA_ASO_01536 84.19 42.89 TGTTTTCAAAGAGCGATCG 125 27774 SNCA_ASO_01537 85.67 62.46 GACCCTCAAGCCATCTAG 126 28598 SNCA_ASO_01538 84.55 62.09 GCTATGACCCTCAAGCCA 127 28603 SNCA_ASO_01539 79.43 43.53 ATGGTTGCCCAGAAGTTA 128 30182 SNCA_ASO_01540 85.01 19.2 AACTAACCACGGCACAAT 129 30829 SNCA_ASO_01541 88.05 53.48 GACTATATAATAGGCTCA 130 33624 SNCA_ASO_01542 84.27 65.84 CTAGCGAAGGACTATATA 131 33633 SNCA_ASO_01543 86.84 64.53 GCTAGCGAAGGACTATAT 132 33634 SNCA_ASO_01544 85.63 53.47 TGCTAGCGAAGGACTATA 133 33635 SNCA_ASO_01545 83.15 28.94 TGAATAGCCTTTGTAGGT 134 38993 SNCA_ASO_01546 81.44 19.91 TAACCCCTTTACAGATCC 135 39060 SNCA_ASO_01547 77.53 22.56 ACTGTGGATGAAGGTTAC 136 40883 SNCA_ASO_01548 84.42 47.1 TGGACAGGCGCTTATCTA 137 41589 SNCA_ASO_01549 82.65 60.99 CTGGACAGGCGCTTATCT 138 41590 SNCA_ASO_01550 72.95 30.2 CTAGGGGTACAACAGGGT 139 43719 SNCA_ASO_01551 78.75 42.33 GTTGGCTGCCCAACTTAC 140 46937 SNCA_ASO_01552 81.93 33.39 TAATAGCCGACATACATC 141 49738 SNCA_ASO_01553 84.56 30.26 TTTTAATAGCCGACATAC 142 49741 SNCA_ASO_01554 68.89 22.27 TATACCCCTGGCATCATA 143 50660 SNCA_ASO_01555 85.37 54.9 ATCTACAGACACGGCTTT 144 52719 SNCA_ASO_01556 81.68 41.97 ATTTTTGACGGATCAGAC 145 52866 SNCA_ASO_01557 78.28 33.62 TAGTTTGGGTCCATGCCA 146 60075 SNCA_ASO_01558 74.77 45.27 GAGGGGTGCTTTTAAGCC 147 60194 SNCA_ASO_01559 85.21 53.15 ATGCTCGAGATTAGTTCT 148 69473 SNCA_ASO_01560 68.51 24.05 GAAGCATGCGGCTACCAT 149 76060 SNCA_ASO_01561 63.79 49.76 GTTCGATAATAGCTAAGC 150 78175 SNCA_ASO_01562 77.35 22.75 AACATCGCCTCAGTCAAT 151 N/A SNCA_ASO_01563 81.73 58.54 GGTATCGTCATGGAATTT 152 N/A SNCA_ASO_01564 52.15 0.9 CTTAAGAGGCTTATATAG 153 N/A SNCA_ASO_01565 74.32 3.9 AATTAAACGAGAGTCTCA 154 N/A SNCA_ASO_01566 59.05 7.62 TAATTGCATCCTAGTAAG 155 99558 SNCA_ASO_01567 69.39 13.29 ACCTGTAGGGTTGAATAG 156 101644 SNCA_ASO_01568 49.87 6.72 AATCCACAGCTATAGTCC 157 106131 SNCA_ASO_01569 40.82 3.27 GGGGAAACATTGCGGCAA 158 106212 SNCA_ASO_01570 82.57 42.67 CGTAGTCTTGATACCCCTT 159 109021 SNCA_ASO_01571 61.43 16.56 TTCGTAGTCTTGATACCC 160 109023 SNCA_ASO_01572 59.6 23.23 GTTCGTAGTCTTGATACC 161 109024

Each modified oligonucleotide listed in Table E is complementary to the human SNCA nucleic acid sequence (SEQ ID NO: 1) and is a 3-10-3 LNA spacer. The equal spacers are 16 nucleobases in length, with a central gap segment comprising ten 2'-deoxynucleosides and each flanking segment on the 5' and 3' ends comprising three LNA nucleosides. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages.

The identified positions in Table E correspond to the "initiation site", ie, the 5' nucleoside complementary to the gapmer in the modified human nucleic acid sequence (SEQ ID NO: 1). Table E: 3-10-3 LNA spacers Compound name % reduction (20 nM ASO) % reduction (2 nM ASO) unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_01442 91.84 91.36 TCATATACGAGTTGAC 162 19976 SNCA_ASO_01443 88.65 70.25 GGGGTTCTCTAACGAC 163 25555 SNCA_ASO_01444 89.05 76.38 TGGGGTTCTCTAACGA 164 25556 SNCA_ASO_01445 86.64 80.33 ATGGGGTTCTCTAACG 165 25557 SNCA_ASO_01446 88.45 88.73 CGATCGGAAGCTCCCT 166 27764 SNCA_ASO_01447 89.46 85.02 GCGATCGGAAGCTCCC 167 27765 SNCA_ASO_01448 88.12 60.51 GAGCGATCGGAAGCTC 168 27767 SNCA_ASO_01449 93.85 89.48 TTCAAGAGCGATCGGA 169 27772 SNCA_ASO_01450 91.9 88.36 TTTCAAGAGCGATCGG 170 27773 SNCA_ASO_01451 92.54 90.88 CTTTAGGTATACGGA 171 30794 SNCA_ASO_01452 92.19 92.64 CCTTTAGAGTATACGG 172 30795 SNCA_ASO_01453 91.27 89.18 CCACGGCACAATTTGA 173 30825 SNCA_ASO_01454 88.09 90.9 TACAACTAACCACGGC 174 30834 SNCA_ASO_01455 90.25 84.95 CTAGCGAAGGACTATA 175 33635 SNCA_ASO_01456 88.63 78.7 GCTAGCGAAGGACTAT 176 33636 SNCA_ASO_01457 90.24 87.29 TGCTAGCGAAGGACTA 177 33637 SNCA_ASO_01458 91.83 83.36 CGTGGCTATATCACTA 178 35363 SNCA_ASO_01459 91.07 86.2 TACTATTCTTACGTGGC 179 35373 SNCA_ASO_01460 88.38 79.63 AGCCGCTACTGCTTAA 180 40922 SNCA_ASO_01461 75.61 36.09 TAGCCGCTACTGCTTA 181 40923 SNCA_ASO_01462 89.37 85.29 CACATAAAGTAGCCGCGC 182 40932 SNCA_ASO_01463 82.9 78.1 TGGACAGGCGCTTATC 183 41591 SNCA_ASO_01464 90.13 76.21 TTAATAGCCGACATAC 184 49741 SNCA_ASO_01465 91.74 90.68 CGATTAATCAACTGGC 185 54363 SNCA_ASO_01466 88.11 82.36 CGGATGTCCGTGTGTG 186 59971 SNCA_ASO_01467 89.87 84.88 GATCGATTAAGTGGAG 187 60754 SNCA_ASO_01468 90.06 81.92 AAGATCGATTAAGTGG 188 60756 SNCA_ASO_01469 89.82 89.77 GCTCGAGATTAGTTCT 189 69473 SNCA_ASO_01470 89.87 84.21 TGCTCGAGATTAGTTC 190 69474 SNCA_ASO_01471 88.72 67.05 ATATGCTCGAGATTAG 191 69477 SNCA_ASO_01472 79.21 76.19 TGTAACCACGCCCTTA 192 72245 SNCA_ASO_01473 84.27 68.53 GAAGCATGCGGCTACC 193 76062 SNCA_ASO_01474 89.88 85.07 TCGATAATAGCTAAGC 194 78175 SNCA_ASO_01475 85 86.87 GGTTCGATAATAGCTA 195 78178 SNCA_ASO_01476 47.73 26.67 GCGGCAACATGGGTTA 196 106203 SNCA_ASO_01477 56.39 28.27 ACATTGCGGCAACATG 197 106208 SNCA_ASO_01478 75.75 34.02 GAAACATTGCGGCAAC 198 106211 SNCA_ASO_01479 89.75 70.77 CGTAGTCTTGATACCC 199 109023 SNCA_ASO_01480 88.96 50.96 TCGTAGTCTTGATACC 200 109024 SNCA_ASO_01481 74.88 36.38 GCTTCAGGTTCGTAGT 201 109033

Each modified oligonucleotide listed in Table F is complementary to the human SNCA nucleic acid sequence (SEQ ID NO: 1) and is a 3-11-3 LNA spacer. The spacer is 17 nucleobases in length, with a central gap segment comprising eleven 2'-deoxynucleosides and flanking segments flanking the 5' and 3' ends comprising three LNA nucleosides. All cytosine residues throughout each gapmer are 5-methylcytosine, and all internucleoside linkages are phosphorothioate linkages.

The identified positions in Table F correspond to the "start site", the 5' nucleoside complementary to the gapmer in the human nucleic acid sequence (SEQ ID NO: 1). Table F: 3-11-3 LNA spacers Compound name % reduction (20 nM ASO) % reduction (2 nM ASO) unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_01482 73.1 58.15 GATACGGTCATTCAGTA 202 12279 SNCA_ASO_01483 91.73 90.53 CTTCATATACGAGTTGA 203 19977 SNCA_ASO_01484 89.5 83.82 GGGTTCTCTAACGACAG 204 25553 SNCA_ASO_01485 86.15 60.66 TGGGGTTCTCTAACGAC 205 25555 SNCA_ASO_01486 85.97 86.26 ATGGGGTTCTCTAACGA 206 25556 SNCA_ASO_01487 85.29 83.66 GCGATCGGAAGCTCCCT 207 27764 SNCA_ASO_01488 86.31 86.29 AGCGATCGGAAGCTCCC 208 27765 SNCA_ASO_01489 82.5 38.59 GAGCGATCGGAAGCTCC 209 27766 SNCA_ASO_01490 85.82 61.64 TTCAAGAGCGATCGGAA 210 27771 SNCA_ASO_01491 85.42 86.32 TTTTCAAGAGCGATCGG 211 27773 SNCA_ASO_01492 88.42 88.97 GTTTTCAAGAGCGATCG 212 27774 SNCA_ASO_01493 90.44 89.31 GTTGCTATCTAGGGATC 213 29772 SNCA_ASO_01494 90.09 84.27 ACCACGGCACAATTTGA 214 30825 SNCA_ASO_01495 89.74 75.35 CTAGCGAAGGACTATAT 215 33634 SNCA_ASO_01496 82.13 56.81 GCTAGCGAAGGACTATA 216 33635 SNCA_ASO_01497 89.66 74.3 TGCTAGCGAAGGACTAT 217 33636 SNCA_ASO_01498 91.93 85 ACGTGGCTATATCACTA 218 35363 SNCA_ASO_01499 87.56 82.24 GCCAGGCGAGAATTTGC 219 40023 SNCA_ASO_01500 80.04 77.83 CTGGACAGGCGCTTATC 220 41591 SNCA_ASO_01501 85.11 71.53 TCTGGACAGGCGCTTAT 221 41592 SNCA_ASO_01502 81.75 39.67 ACGTGGCCAGATCAATC 222 48684 SNCA_ASO_01503 92.39 82.02 ATCTACAGACACGGCTT 223 52720 SNCA_ASO_01504 84.65 71.57 GCCTCACGGATGTCCGT 224 59976 SNCA_ASO_01505 89.07 78.71 AGATCGATTAAGTGGAG 225 60754 SNCA_ASO_01506 87.82 68.11 ATAAGATCGATTAAGTG 226 60757 SNCA_ASO_01507 88.38 83.61 GCGTATGGGCATCTCCA 227 64115 SNCA_ASO_01508 89.95 81.02 TGCGTATGGGCATCTCC 228 64116 SNCA_ASO_01509 84.51 85.54 CTTTCTGCGTATGGGCA 229 64121 SNCA_ASO_01510 86.8 85 GCTTTCTGCGTATGGGC 230 64122 SNCA_ASO_01511 86.12 76.59 GACCTCCATCAGTAGTA 231 65615 SNCA_ASO_01512 87.88 85.32 TCGAGATTAGTTTCTTCC 232 69470 SNCA_ASO_01513 88.06 85.21 CTCGAGATTAGTTCTTC 233 69471 SNCA_ASO_01514 87.53 84.41 GCTCGAGATTAGTTCTT 234 69472 SNCA_ASO_01515 87.05 84.6 TGCTCGAGATTAGTTCT 235 69473 SNCA_ASO_01516 78.8 80.93 TATCTGTAACCACGCCC 236 72248 SNCA_ASO_01517 43.2 14.63 TGCGGCTACCATGCTAC 237 76055 SNCA_ASO_01518 27.72 4.5 GCATGCGGCTACCATGC 238 76058 SNCA_ASO_01519 86.73 80.28 GTTCGATAATAGCTAAG 239 78176 SNCA_ASO_01520 82.4 83.76 GGTTCGATAATAGCTAA 240 78177 SNCA_ASO_01521 87.9 84.41 GAAGAGATGGTTCGATA 241 78185 SNCA_ASO_01522 85.18 77.71 AATCGTGTTTTATCCTCG 242 N/A SNCA_ASO_01523 78.22 46.69 GGAAACATTGCGGCAAC 243 106211 SNCA_ASO_01524 88.01 76.7 CGTAGTCTTGATACCCT 244 109022 SNCA_ASO_01525 90.64 72.76 TCGTAGTCTTGATACCC 245 109023 SNCA_ASO_01526 69.2 54.44 GCTTCAGGTTCGTAGTC 246 109032 SNCA_ASO_01527 77.67 52.98 TAGGCTTCAGGTTCGTA 247 N/A Example 2: In vitro mRNA reduction following a single dose of MOE-modified ASO

Modified oligonucleotides complementary to human SNCA nucleic acid sequences were designed and tested in vitro in primary cortical neurons for their selective utility in reducing the amount of SNCA mRNA. Neurons were treated with 300 nM of each antisense oligonucleotide. The amount of mRNA was quantified using qRT-PCR (TaqMan ^™ ) with the following probes: TGGCAACAGTGGCTGAGAAGACCAA (SEQ ID NO: 248) with primer Hs00240906_m1 SNCA (ThermoFisher), and CCAAGACTGAATGNOGCTGGATGGCAA (SEQ ID NO: 248) with primer PPIA_Mm02342430_g1 (ThermoFisher) control).

Each of the modified oligonucleotides listed in Table G and Table H is complementary to a human SNCA DNA (SEQ ID NO: 1 ) or mRNA (SEQ ID NO: 3) sequence. The sequences in Table G are complementary to the exons in the mRNA sequence, and the sequences in Table H are complementary to the introns in the mRNA sequence. Each ASO is a 5-10-5 MOE spacer, 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxynucleosides and flanking segments on both 5' and 3' ends comprising five 2'-MOE nucleosides. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages.

The positions identified in Table G and Table H correspond to the "initiation site", ie, the 5' nucleoside complementary to the gapmer in the modified human nucleic acid sequences of SEQ ID NO: 1 and SEQ ID NO: 3. "#N/A" indicates that the sequence does not align with SEQ ID NO: 1 (eg, where the sequence bridges exon-exon junctions that are only present in mature mRNA). Form G: with SNCA MOE-modified ASO for RNA exon complementation Compound name SNCA mRNA reduction % unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 3 Position in SEQ ID NO: 1 SNCA_ASO_00031 59 TCCTTGGCCTTTGAAAGTCC 250 19 19 SNCA_ASO_00033 81 CCAACATTTGTCACTTGCTC 251 181 13307 SNCA_ASO_00037 60 CCTTTCATGAATACATCCAT 252 1 1 SNCA_ASO_00038 67 TCCTTTCATGAATACATCCA 253 2 2 SNCA_ASO_00039 70 GTCCTTTCATGAATACATCC 254 3 3 SNCA_ASO_00040 69 AGTCCTTTTCATGAATACATC 255 4 4 SNCA_ASO_00041 62 AAGTCCTTTCATGAATACAT 256 5 5 SNCA_ASO_00042 41 CTTGGCCTTTGAAAGTCCTT 257 17 17 SNCA_ASO_00043 60 CCTTGGCCTTTGAAAGTCCT 258 18 18 SNCA_ASO_00044 63 CTCCTTGGCCTTTGAAAGTC 259 20 20 SNCA_ASO_00045 64 CCTCCTTGGCCTTTGAAAGT 260 twenty one twenty one SNCA_ASO_00046 73 CCCTCCTTGGCCTTTGAAAG 261 twenty two twenty two SNCA_ASO_00047 79 TCCCTCCTTGGCCTTTGAAA 262 twenty three twenty three SNCA_ASO_00048 50 CTCCCTCCTTGGCCTTTGAA 263 twenty four twenty four SNCA_ASO_00049 61 ACTCCCTCCTTGGCCTTTGA 264 25 25 SNCA_ASO_00050 71 AACTCCCTCCTTGGCCTTTG 265 26 26 SNCA_ASO_00051 64 CAACTCCCTCCTTGGCCTTT 266 27 27 SNCA_ASO_00052 58 ACAACTCCCTCCTTGGCCTT 267 28 28 SNCA_ASO_00053 38 CACAACTCCCTCCTTGGCCT 268 29 29 SNCA_ASO_00054 82 CCACAACTCCCTCCTTGGCC 269 30 30 SNCA_ASO_00055 63 GCCACAACTCCCTCCTTGGC 270 31 31 SNCA_ASO_00056 72 AGCCACAACTCCCTCCTTGG 271 32 32 SNCA_ASO_00057 76 CAGCCACAACTCCCTCCTTG 272 33 33 SNCA_ASO_00058 72 GCAGCCACAACTCCCTCCTT 273 34 34 SNCA_ASO_00059 51 TCAGCAGCAGCCACAACTCC 274 40 40 SNCA_ASO_00060 43 CTCAGCAGCAGCCACAACTC 275 41 41 SNCA_ASO_00061 36 TCTCAGCAGCAGCCACAACT 276 42 42 SNCA_ASO_00062 34 TTCTCAGCAGCAGCAGCCACAAC 277 43 43 SNCA_ASO_00063 36 TTTCTCAGCAGCAGCCACAA 278 44 44 SNCA_ASO_00064 38 TTTTCTCAGCAGCAGCACA 279 45 45 SNCA_ASO_00065 32 GTTTTCTCAGCAGCAGCCAC 280 46 46 SNCA_ASO_00066 49 GGTTTTTCTCAGCAGCAGCAGCCA 281 47 47 SNCA_ASO_00067 45 TGGTTTTTCTCAGCAGCAGCC 282 48 48 SNCA_ASO_00068 35 TTGGTTTTTCTCAGCAGCAGCAGC 283 49 49 SNCA_ASO_00069 39 TTTGGTTTTTCTCAGCAGCAG 284 50 50 SNCA_ASO_00070 60 GTTTGGTTTTTCTCAGCAGCA 285 51 51 SNCA_ASO_00071 51 TGTTTGGTTTTTCTCAGCAGC 286 52 52 SNCA_ASO_00072 34 CTGTTTGGTTTTTCTCAGCAG 287 53 53 SNCA_ASO_00073 56 CCTGTTTGGTTTTTCTCAGCA 288 54 54 SNCA_ASO_00074 48 CCCTGTTTGGTTTTTCTCAGC 289 55 55 SNCA_ASO_00075 53 ACCCTGTTTGGTTTTTCTCAG 290 56 56 SNCA_ASO_00076 65 CACCCTGTTTGGTTTTTCCA 291 57 57 SNCA_ASO_00077 62 ACACCCTGTTTGGTTTTCTC 292 58 58 SNCA_ASO_00078 63 CACACCCTGTTTGGTTTTCT 293 59 59 SNCA_ASO_00079 64 CCACACCCTGTTTGGTTTTC 294 60 60 SNCA_ASO_00080 82 GCCACACCCTGTTTGGTTTT 295 61 61 SNCA_ASO_00081 59 TGCCACACCCTGTTTGGTTT 296 62 62 SNCA_ASO_00082 50 CTGCCACACCCTGTTTGGTT 297 63 63 SNCA_ASO_00083 59 TCTGCCACACCCTGTTTGGT 298 64 64 SNCA_ASO_00084 39 TTCTGCCACACCCTGTTTGG 299 65 65 SNCA_ASO_00085 54 CTTCTGCCACACCCTGTTTG 300 66 66 SNCA_ASO_00086 56 GCTTCTGCCACACCCTGTTT 301 67 67 SNCA_ASO_00087 67 TGCTTCTGCCACACCCTGTT 302 68 68 SNCA_ASO_00088 65 CTGCTTCTGCCACACCCTGT 303 69 69 SNCA_ASO_00089 71 GCTGCTTCTGCCACACCCTG 304 70 70 SNCA_ASO_00090 70 TGCTGCTTCTGCCACACCCT 305 71 71 SNCA_ASO_00091 78 CTGCTGCTTCTGCCACACCC 306 72 72 SNCA_ASO_00092 63 CCTGCTGCTTCTGCCACACC 307 73 73 SNCA_ASO_00093 63 TCCTGCTGCTTCTGCCACAC 308 74 74 SNCA_ASO_00094 50 TTCCTGCTGCTTCTGCCACA 309 75 75 SNCA_ASO_00095 49 TTTCCTGCTGCTTCTGCCAC 310 76 76 SNCA_ASO_00096 41 CTTTCCTGCTGCTTCTGCCA 311 77 77 SNCA_ASO_00097 37 TCTTTCCTGCTGCTTCTGCC 312 78 78 SNCA_ASO_00098 48 GTCTTTCCTGCTGCTTCTGC 313 79 79 SNCA_ASO_00099 45 TGTCTTTCCTGCTGCTTCTG 314 80 80 SNCA_ASO_00100 55 TTGTCTTTCCTGCTGCTTCT 315 81 81 SNCA_ASO_00101 43 TTTGTCTTTCCTGCTGCTTC 316 82 82 SNCA_ASO_00102 35 TTTTGTCTTTCCTGCTGCTT 317 83 83 SNCA_ASO_00103 45 CTTTTGTCTTTCCTGCTGCT 318 84 84 SNCA_ASO_00104 49 TCTTTTGTCTTTCCTGCTGC 319 85 85 SNCA_ASO_00105 49 CTCTTTTGTCTTTCCTGCTG 320 86 86 SNCA_ASO_00106 64 CCTCTTTTGTCTTTCCTGCT 321 87 87 SNCA_ASO_00107 68 CCCTCTTTTGTCTTTCCTGC 322 88 88 SNCA_ASO_00108 56 ACCCTCTTTTGTCTTTCCTG 323 89 89 SNCA_ASO_00109 53 CACCCTCTTTTGTCTTTCCT 324 90 90 SNCA_ASO_00110 41 ACACCCTCTTTTGTCTTTTCC 325 91 91 SNCA_ASO_00111 41 AACACCCTCTTTTGTCTTTC 326 92 92 SNCA_ASO_00112 34 GAACACCCTCTTTTGTCTTT 327 93 93 SNCA_ASO_00113 40 AGAACACCCTCTTTTGTCTT 328 94 94 SNCA_ASO_00114 48 GAGAACACCCTCTTTTGTCT 329 95 95 SNCA_ASO_00115 45 CCTACATAGAGAACACCCTC 330 103 103 SNCA_ASO_00116 75 GCCTACATAGAGACACCCT 331 104 #N/A SNCA_ASO_00117 66 AGCCTACATAGAGAACACCC 332 105 #N/A SNCA_ASO_00118 57 GAGCCTACATAGAGAACACC 333 106 #N/A SNCA_ASO_00119 59 GGAGCCTACATAGAGAACAC 334 107 #N/A SNCA_ASO_00120 45 TGGAGCCTACATAGAGAACA 335 108 #N/A SNCA_ASO_00121 49 TTGGAGCCTACATAGAGAAC 336 109 #N/A SNCA_ASO_00122 33 TTTGGAGCCTACATAGAGAA 337 110 #N/A SNCA_ASO_00123 36 TTTTGGAGCCTACATAGAGA 338 111 #N/A SNCA_ASO_00124 35 GTTTTGGAGCCTACATAGAG 339 112 #N/A SNCA_ASO_00125 51 GGTTTTGGAGCCTACATAGA 340 113 #N/A SNCA_ASO_00126 60 TGGTTTTGGAGCCTACATAG 341 114 #N/A SNCA_ASO_00127 56 TTGGTTTTGGAGCCTACATA 342 115 #N/A SNCA_ASO_00128 55 CTTGGTTTTGGAGCCTACAT 343 116 #N/A SNCA_ASO_00129 59 CCTTGGTTTTGGAGCCTACA 344 117 7488 SNCA_ASO_00130 62 TCCTTGGTTTTGGAGCCTAC 345 118 7489 SNCA_ASO_00131 50 ACTCCCTCCTTGGTTTTGGA 346 124 7495 SNCA_ASO_00132 53 CACTCCCTCCTTGGTTTTGG 347 125 7496 SNCA_ASO_00133 69 CCACTCCCTCCTTGGTTTTG 348 126 7497 SNCA_ASO_00134 74 TCAGCCACTGTTGCCACACC 349 151 #N/A SNCA_ASO_00135 74 CTCAGCCACTGTTGCCACAC 350 152 #N/A SNCA_ASO_00136 60 TCTCAGCCACTGTTGCCACA 351 153 #N/A SNCA_ASO_00137 52 TTCTCAGCCACTGTTGCCAC 352 154 #N/A SNCA_ASO_00138 64 CTTCTCAGCCACTGTTGCCA 353 155 #N/A SNCA_ASO_00139 62 TCTTCTCAGCCACTGTTGCC 354 156 #N/A SNCA_ASO_00140 69 GTCTTCTCAGCCACTGTTGC 355 157 #N/A SNCA_ASO_00141 71 GGTCTTTCTCAGCCACTGTTG 356 158 #N/A SNCA_ASO_00142 68 TGGTCTTTCTCAGCCACTGTT 357 159 #N/A SNCA_ASO_00143 58 TTGGTCTTTCTCAGCCACTGT 358 160 #N/A SNCA_ASO_00144 40 TTTGGTCTTTCTCAGCCACTG 359 161 13287 SNCA_ASO_00145 65 CTTGCTCTTTGGTCTTTCTCA 360 168 13294 SNCA_ASO_00146 62 ACTTGCTCTTTGGTCTTCTC 361 169 13295 SNCA_ASO_00147 72 TGTCACTTGCTCTTTGGTCT 362 173 13299 SNCA_ASO_00148 70 TTGTCACTTGCTCTTTGGTC 363 174 13300 SNCA_ASO_00149 51 TTTGTCACTTGCTCTTTGGT 364 175 13301 SNCA_ASO_00150 57 ATTTGTCACTTGCTCTTTGG 365 176 13302 SNCA_ASO_00151 59 CATTTGTCACTTGCTCTTTG 366 177 13303 SNCA_ASO_00152 60 ACATTTGTCACTTGCTCTTT 367 178 13304 SNCA_ASO_00153 71 AACATTTGTCACTTGCTCTT 368 179 13305 SNCA_ASO_00154 74 CAACATTTGTCACTTGCTCT 369 180 13306 SNCA_ASO_00155 80 TCCAACATTTGTCACTTGCT 370 182 13308 SNCA_ASO_00156 76 CTCCAACATTTGTCACTTGC 371 183 13309 SNCA_ASO_00157 77 CTCCTCCAACATTTGTCACT 372 186 13312 SNCA_ASO_00158 70 GCTCCTCCAACATTTGTCAC 373 187 13313 SNCA_ASO_00159 66 GCTGTCACACCCGTCACCAC 374 208 13334 SNCA_ASO_00160 48 TGCTGTCACACCCGTCACCA 375 209 13335 SNCA_ASO_00161 63 CTGCTGTCACACCCGTCACC 376 210 13336 SNCA_ASO_00162 67 ACTGCTGTCACACCCGTCAC 377 211 13337 SNCA_ASO_00163 55 TACTGCTGTCACACCCGTCA 378 212 13338 SNCA_ASO_00164 51 CTACTGCTGTCACACCCGTC 379 213 13339 SNCA_ASO_00165 70 GCTACTGCTGTCACACCCGT 380 214 13340 SNCA_ASO_00166 69 GGCTACTGCTGTCACACCCG 381 215 13341 SNCA_ASO_00167 52 GGGCTACTGCTGTCACACCC 382 216 13342 SNCA_ASO_00168 45 TGGGCTACTGCTGTCACACC 383 217 13343 SNCA_ASO_00169 6 CTGGGCTACTGCTGTCACAC 384 218 13344 SNCA_ASO_00170 29 TCTGGGCTACTGCTGTCACA 385 219 13345 SNCA_ASO_00171 29 TTCTGGGCTACTGCTGTCAC 386 220 13346 SNCA_ASO_00172 12 CTTCTGGGCTACTGCTGTCA 387 221 13347 SNCA_ASO_00173 twenty four TCTTCTGGGCTACTGCTGTC 388 222 13348 SNCA_ASO_00174 39 GTCTTCTGGGCTACTGCTGT 389 223 13349 SNCA_ASO_00175 44 TGTCTTCTGGGCTACTGCTG 390 224 13350 SNCA_ASO_00176 36 CTGTCTTCTGGGCTACTGCT 391 225 13351 SNCA_ASO_00177 38 ACTGTCTTCTGGGCTACTGC 392 226 13352 SNCA_ASO_00178 43 CACTGTCTTCTGGGCTACTG 393 227 13353 SNCA_ASO_00179 66 CCACTGTCTTCTGGGCTACT 394 228 13354 SNCA_ASO_00180 34 TCCACTGTCTTCTGGGCTAC 395 229 13355 SNCA_ASO_00181 61 CTCCACTGTCTTCTGGGCTA 396 230 13356 SNCA_ASO_00182 36 CCTCCACTGTCTTCTGGGCT 397 231 13357 SNCA_ASO_00183 45 CCCTCCACTGTCTTCTGGGC 398 232 13358 SNCA_ASO_00184 42 TCCTCCCACTGTCTTCTGGG 399 233 13359 SNCA_ASO_00185 62 CTCCTCTCACTGTCTTCTGG 400 234 13360 SNCA_ASO_00186 80 GCTCCTCCCACTGTCTTCTG 401 235 13361 SNCA_ASO_00187 79 TGCTCCCTCCACTGTCTTCT 402 236 13362 SNCA_ASO_00188 83 CTGCTCCCTCCACTGTCTTC 403 237 13363 SNCA_ASO_00189 80 CCCTGCTCCCTCCACTGTCT 404 239 13365 SNCA_ASO_00190 77 TCCCTGCTCCCTCCACTGTC 405 240 13366 SNCA_ASO_00191 39 CTCCCTGCTCCCTCACTGT 406 241 13367 SNCA_ASO_00192 88 GCTCCCTGCTCCCTCCACTG 407 242 13368 SNCA_ASO_00193 86 TGCTCCCTGCTCCCTCACT 408 243 13369 SNCA_ASO_00194 78 ATGCTCCCTGCTCCCCTCCAC 409 244 13370 SNCA_ASO_00195 78 AATGCTCCCTGCTCCCTCCA 410 245 13371 SNCA_ASO_00196 41 CAATGCTCCCTGCTCCCTCC 411 246 13372 SNCA_ASO_00197 62 GCAATGCTCCCTGCTCCCTC 412 247 13373 SNCA_ASO_00198 64 TGCAATGCTCCCTGCTCCCT 413 248 13374 SNCA_ASO_00199 73 CTGCAATGCTCCCTGCTCCC 414 249 13375 SNCA_ASO_00200 52 GCTGCAATGCTCCCTGCTCC 415 250 13376 SNCA_ASO_00201 14 TGCTGCAATGCTCCCTGCTC 416 251 13377 SNCA_ASO_00202 40 CTGCTGCAATGCTCCCTGCT 417 252 13378 SNCA_ASO_00203 58 GCTGCTGCAATGCTCCCTGC 418 253 13379 SNCA_ASO_00204 26 GGCTGCTGCAATGCTCCCTG 419 254 13380 SNCA_ASO_00205 34 TGGCTGCTGCAATGCTCCCT 420 255 13381 SNCA_ASO_00206 33 GTGGCTGCTGCAATGCTCCC 421 256 13382 SNCA_ASO_00207 28 AGTGGCTGCTGCAATGCTCC 422 257 13383 SNCA_ASO_00208 19 CAGTGGCTGCTGCAATGCTC 423 258 13384 SNCA_ASO_00209 31 CCAGTGGCTGCTGCAATGCT 424 259 13385 SNCA_ASO_00210 36 GCCAGTGGCTGCTGCAATGC 425 260 13386 SNCA_ASO_00211 48 GCCCAACTGGTCCTTTTTGA 426 284 13410 SNCA_ASO_00212 41 TGCCCAACTGGTCCTTTTTG 427 285 13411 SNCA_ASO_00213 32 TTGCCCAACTGGTCCTTTTT 428 286 13412 SNCA_ASO_00214 26 CTTGCCCAACTGGTCCTTTT 429 287 13413 SNCA_ASO_00215 78 TCTTGCCCAACTGGTCCTTT 430 288 #N/A SNCA_ASO_00216 34 TTCTTGCCCAACTGGTCCTT 431 289 #N/A SNCA_ASO_00217 39 ATTCTTGCCCAACTGGTCCT 432 290 #N/A SNCA_ASO_00218 35 CATTCTTGCCCAACTGGTCC 433 291 #N/A SNCA_ASO_00219 36 TCATTCTTGCCCAACTGGTC 434 292 #N/A SNCA_ASO_00220 50 TTCATTCTTGCCCAACTGGT 435 293 #N/A SNCA_ASO_00221 51 CTTCATTCTTGCCCAACTGG 436 294 #N/A SNCA_ASO_00222 45 TCTTCATTCTTGCCCAACTG 437 295 #N/A SNCA_ASO_00223 43 TTCTTCATTCTTGCCCAACT 438 296 #N/A SNCA_ASO_00224 32 CTTCTTCATTCTTGCCCAAC 439 297 #N/A SNCA_ASO_00225 32 CCTTCTTCATTCTTGCCCAA 440 298 #N/A SNCA_ASO_00226 45 TCCTTCTTCATTCTTGCCCA 441 299 #N/A SNCA_ASO_00227 49 CTCCTTCTTCATTCTTGCCC 442 300 #N/A SNCA_ASO_00228 62 GCTCCTTCTTCATTCTTGCC 443 301 #N/A SNCA_ASO_00229 54 GGCTCTTCTTCATTCTTGC 444 302 #N/A SNCA_ASO_00230 53 GGGCTCCTTCTTCATTCTTG 445 303 #N/A SNCA_ASO_00231 38 GGGGCTCCTTCTTCATTCTT 446 304 #N/A SNCA_ASO_00232 37 TGGGGCTCCTTCTTCATTCT 447 305 106399 SNCA_ASO_00233 36 GTGGGGCTCCTTCTTCATTC 448 306 106400 SNCA_ASO_00234 18 TGTGGGGCTCCTTCTTCATT 449 307 106401 SNCA_ASO_00235 15 CTGTGGGGCTCCTTCTTCAT 450 308 106402 SNCA_ASO_00236 44 CCTGTGGGGCTCCTTCTTCA 451 309 106403 SNCA_ASO_00237 44 TCCTGTGGGGCTCCTTCTTC 452 310 106404 SNCA_ASO_00238 29 TTCCTGTGGGGCTCCTTCTT 453 311 106405 SNCA_ASO_00239 40 CTTCCTGTGGGGCTCCTTCT 454 312 106406 SNCA_ASO_00240 44 CCTTCCTGTGGGGCTCCTTC 455 313 106407 SNCA_ASO_00241 54 TCCTTCCTGTGGGGCTCCTT 456 314 106408 SNCA_ASO_00242 35 TTCCTTCCTGTGGGGCTCCT 457 315 106409 SNCA_ASO_00243 34 ATTCCTTCCTGTGGGGCTCC 458 316 106410 SNCA_ASO_00244 27 AATTCCTTCCTGTGGGGCTC 459 317 106411 SNCA_ASO_00245 0 GAATTCCTTCCTGTGGGGCT 460 318 106412 SNCA_ASO_00246 0 AGAATTCCTTCCTGTGGGGC 461 319 106413 SNCA_ASO_00247 11 AGGATCCACAGGCATATCTT 462 341 106435 SNCA_ASO_00248 17 CAGGATCCACAGGCATATCT 463 342 106436 SNCA_ASO_00249 34 TCAGGATCCACAGGCATATC 464 343 106437 SNCA_ASO_00250 50 GTCAGGATCCACAGGCATAT 465 344 106438 SNCA_ASO_00251 38 TGTCAGGATCCACAGGCATA 466 345 106439 SNCA_ASO_00252 40 TTGTCAGGATCCACAGGCAT 467 346 106440 SNCA_ASO_00253 48 AGCCTCATTGTCAGGATCCA 468 353 106447 SNCA_ASO_00254 39 AAGCCTCATTGTCAGGATCC 469 354 106448 SNCA_ASO_00255 29 TAAGCCTCATTGTCAGGATC 470 355 106449 SNCA_ASO_00256 20 ATAAGCCTCATTGTCAGGAT 471 356 106450 SNCA_ASO_00257 37 CATAAGCCTCATTGTCAGGA 472 357 106451 SNCA_ASO_00258 27 GCATTTCATAAGCCTCATTG 473 363 106457 SNCA_ASO_00259 26 GGCATTTCATAAGCCTCATT 474 364 106458 SNCA_ASO_00260 0 CAGAAGGCATTTCATAAGCC 475 369 106463 SNCA_ASO_00261 14 TCAGAAGGCATTTCATAAGC 476 370 106464 SNCA_ASO_00262 12 CTCAGAAGGCATTTCATAAG 477 371 106465 SNCA_ASO_00263 28 CCTCAGAAGGCATTTCATAA 478 372 106466 SNCA_ASO_00264 17 TCCTCAGAAGGCATTTCATA 479 373 #N/A SNCA_ASO_00265 1 TTCCTCAGAAGGCATTTCAT 480 374 #N/A SNCA_ASO_00266 36 CTTGATACCCTTCCTCAGAA 481 384 #N/A SNCA_ASO_00267 31 TCTTGATACCCTTCCTCAGA 482 385 #N/A SNCA_ASO_00268 44 GTCTTGATACCCTTCCTCAG 483 386 #N/A SNCA_ASO_00269 51 AGTCTTGATACCCTTCCTCA 484 387 #N/A SNCA_ASO_00270 41 TAGTCTTGATACCCTTCCTC 485 388 #N/A SNCA_ASO_00271 61 GTAGTCTTGATACCCTTCCT 486 389 109018 SNCA_ASO_00272 59 CGTAGTCTTGATACCCTTCC 49 390 109019 SNCA_ASO_00273 80 TCGTAGTCTTGATACCCTTC 487 391 109020 SNCA_ASO_00274 51 TTCGTAGTCTTGATACCCCTT 488 392 109021 SNCA_ASO_00275 59 GTTCGTAGTCTTGATACCCT 50 393 109022 SNCA_ASO_00276 39 GGTTCGTAGTCTTGATACCC 51 394 109023 SNCA_ASO_00277 27 AGGTTCGTAGTCTTGATACC 52 395 109024 SNCA_ASO_00278 50 CAGGTTCGTAGTCTTGATAC 53 396 109025 SNCA_ASO_00279 32 TCAGGTTCGTAGTCTTGATA 489 397 109026 SNCA_ASO_00280 28 TTCAGGTTCGTAGTCTTGAT 54 398 109027 SNCA_ASO_00281 66 CTTCAGGTTCGTAGTCTTGA 490 399 109028 SNCA_ASO_00282 54 GCTTCAGGTTCGTAGTCTTG 491 400 109029 SNCA_ASO_00283 38 GGCTTCAGGTTCGTAGTCTT 492 401 109030 SNCA_ASO_00284 7 AGGCTTCAGGTTCGTAGTCT 493 402 109031 SNCA_ASO_00285 31 TAGGCTTCAGGTTCGTAGTC 494 403 #N/A SNCA_ASO_00286 67 TTAGGCTTCAGGTTCGTAGT 495 404 #N/A Form H: with SNCA RNA Intron Complementary MOE Modified ASO Compound name SNCA % decrease in mRNA unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_00446 32 TACCTCTGACTCAGTCCACC 496 243 SNCA_ASO_00447 37 ATACCTCTGACTCAGTCCAC 497 244 SNCA_ASO_00448 38 ACAGGGGCATATCAAAGTCA 498 547 SNCA_ASO_00449 59 CCCTCAAGCACTTTTTCTCTG 499 671 SNCA_ASO_00450 58 CAGCCCTCAAGCACTTTTTCT 500 674 SNCA_ASO_00451 45 TCAGCTAGGCAACTCAATGT 501 1058 SNCA_ASO_00452 45 TGTTTCAGCTAGGCAACTCA 502 1062 SNCA_ASO_00453 59 ACAAGACAATTCCAGCCCAC 503 2298 SNCA_ASO_00454 65 TGGTTTGTGTGATTAGTGCA 504 2358 SNCA_ASO_00455 17 GGGAAGTGATGCTCAGAGAT 505 2438 SNCA_ASO_00456 44 GAGTGGAGAAGAAGGTCAGA 506 3188 SNCA_ASO_00457 61 AAAAGAGCACAGAGTGGAGA 507 3199 SNCA_ASO_00458 61 CCCAACCTCAAAAGAGCACA 508 3208 SNCA_ASO_00459 52 TCCCAACCTCAAAAGAGCAC 509 3209 SNCA_ASO_00460 4 TTCCCAACCTCAAAAGAGCA 510 3210 SNCA_ASO_00461 20 CTTCCCAACCTCAAAAGAGC 511 3211 SNCA_ASO_00462 75 CTTGTCTTTCCCAAACCTCAAA 512 3216 SNCA_ASO_00463 69 ATCTTGTCTTTCCCAAACCTCA 513 3218 SNCA_ASO_00464 48 CCCTTGCCACAAAAACAACA 514 4049 SNCA_ASO_00465 38 GCCCTTGCCACAAAAACAAC 515 4050 SNCA_ASO_00466 36 TGCCCTTGCCACAAAAACAA 516 4051 SNCA_ASO_00467 46 GCTGCCCTTGCCACAAAAAC 517 4053 SNCA_ASO_00468 75 TGGATTTTAGCTGCCCTTGC 518 4062 SNCA_ASO_00469 twenty two TGCTTGGAATCCCAGTGCTT 519 4965 SNCA_ASO_00470 47 TTGCTTGGAATCCCAGTGCT 520 4966 SNCA_ASO_00471 48 CTTGCTTGGAATCCCAGTGC 521 4967 SNCA_ASO_00472 57 AGAGGCTGACAAGGGTAAGA 522 5403 SNCA_ASO_00473 61 GGGCATTGCTGTCTGTATGA 523 5909 SNCA_ASO_00474 78 GCAGTGACAACATCCTCAGG 524 6106 SNCA_ASO_00475 82 CAGCAGTGACAACATCCTCA 525 6108 SNCA_ASO_00476 49 AATTGCAGCAGTGACAACAT 526 6113 SNCA_ASO_00477 61 TGAATTGCAGCAGTGACAAC 527 6115 SNCA_ASO_00478 64 CTGGGACACCTTCACTCTTT 528 6209 SNCA_ASO_00479 71 CCCTTTGTTCCCACATCACA 529 7210 SNCA_ASO_00480 52 CCCCTTTGTTCCCACATCAC 530 7211 SNCA_ASO_00481 67 TCCCCTTTGTTCCCACATCA 531 7212 SNCA_ASO_00482 75 ATCCCCTTTGTTCCCACATC 532 7213 SNCA_ASO_00483 60 TATCCCCTTTGTTCCCACAT 533 7214 SNCA_ASO_00484 69 TTATCCCCTTTGTTCCCACA 534 7215 SNCA_ASO_00485 49 AGCTTACCTGTTGCCACACC 535 7522 SNCA_ASO_00486 twenty two GAGCTTACCTGTTGCCACAC 536 7523 SNCA_ASO_00487 0 GGAGCTTACCTGTTGCCACA 537 7524 SNCA_ASO_00488 0 TGGAGCTTACCTGTTGCCAC 538 7525 SNCA_ASO_00489 62 TGGGCCACACTAATCACTAG 539 7579 SNCA_ASO_00490 56 ACTGGGCCACACTAATCACT 540 7581 SNCA_ASO_00491 39 ATACTGGGCCACACTAATCA 541 7583 SNCA_ASO_00492 66 TTTCTGGCACTTCTCATCCTC 542 8181 SNCA_ASO_00493 37 CAGAGCCCATTAAAGGTGCA 543 8791 SNCA_ASO_00494 46 ACAGAGCCCATTAAAGGTGC 544 8792 SNCA_ASO_00495 28 AACAGAGCCCATTAAAGGTG 545 8793 SNCA_ASO_00496 12 CAACAGAGCCCATTAAAGGT 546 8794 SNCA_ASO_00497 27 GCAACAGAGCCCATTAAAGG 547 8795 SNCA_ASO_00498 37 TGCAACAGAGCCCATTAAAG 548 8796 SNCA_ASO_00499 43 TTGCAACAGAGCCCATTAAA 549 8797 SNCA_ASO_00500 45 ATTGCAACAGAGCCCATTAA 550 8798 SNCA_ASO_00501 52 GATTGCAACAGAGCCCATTA 551 8799 SNCA_ASO_00502 55 GGATTGCAACAGAGCCCATT 552 8800 SNCA_ASO_00503 49 TGGATTGCAACAGAGCCCAT 553 8801 SNCA_ASO_00504 36 TTGGATTGCAACAGAGCCCA 554 8802 SNCA_ASO_00505 75 CTCATGGGTTCTTCCTCAAC 555 8980 SNCA_ASO_00506 63 ACCTCATGGGTTCTTCCTCA 556 8982 SNCA_ASO_00507 40 TTCACTACTGCCAGGGTGGT 557 9545 SNCA_ASO_00508 35 ACTCCCCAGATAAGCCTCAG 558 11985 SNCA_ASO_00509 0 TGGGGACACTCATCTAAGGA 559 12036 SNCA_ASO_00510 0 GAGAGTGGAGGATGGGGACA 560 12048 SNCA_ASO_00511 26 GAACAGTGGAGGAGAGTGGA 561 12059 SNCA_ASO_00512 26 GAGAACAGTGGAGGAGAGTG 562 12061 SNCA_ASO_00513 43 TCTCAGCCACTGGTACAAAT 563 13279 SNCA_ASO_00514 27 TTCTCAGCCACTGGTACAAA 564 13280 SNCA_ASO_00515 twenty three CAAGGGGAGGGTCAGGTAGC 565 13537 SNCA_ASO_00516 1 ACAAGGGGAGGGTCAGGTAG 566 13538 SNCA_ASO_00517 36 CACAAGGGGAGGGTCAGGTA 567 13539 SNCA_ASO_00518 80 GTCAGGGCAAGGGTATGCTT 568 14182 SNCA_ASO_00519 82 TGTCAGGGCAAGGGTATGCT 569 14183 SNCA_ASO_00520 80 CACTCTCATGGTGCCTACAT 570 14572 SNCA_ASO_00521 87 TTCACTCTCATGGTGCCTAC 571 14574 SNCA_ASO_00522 80 TTTCACTCTCATGGTGCCTA 572 14575 SNCA_ASO_00523 93 ATTTCACTCTCATGGTGCCT 573 14576 SNCA_ASO_00524 88 GGAAACTTCCCCAGACACTT 574 14624 SNCA_ASO_00525 91 TGGAAACTCTCCCAGACACT 575 14625 SNCA_ASO_00526 74 TCTTGGACTACCCACTTCCT 576 15415 SNCA_ASO_00527 79 GGGGAAGTGATATAGTGGCT 577 15480 SNCA_ASO_00528 66 TGGGGAAGTGATATAGTGGC 578 15481 SNCA_ASO_00529 68 AGACCCCAAAGGAAGGTAAGT 579 15515 SNCA_ASO_00530 95 GTACATGTTTCCCCTGTTGCT 580 15596 SNCA_ASO_00531 84 AGGTGGTGTATGAGCAGAGA 581 15916 SNCA_ASO_00532 77 CAGGTGGTGTATGAGCAGAG 582 15917 SNCA_ASO_00533 67 GTCAGGTGGTGTATGAGCAG 583 15919 SNCA_ASO_00534 87 AGTCAGGTGGTGTATGAGCA 584 15920 SNCA_ASO_00535 88 CAGTCAGGTGGTGTATGAGC 585 15921 SNCA_ASO_00536 75 CCAGTCAGGTGGTGTATGAG 586 15922 SNCA_ASO_00537 94 CCGGTGCCATTACTCCCTTT 7 16401 SNCA_ASO_00538 74 TGGGATAGACCAAGTGTTCT 587 17009 SNCA_ASO_00539 92 GCAAGACACTGTTGAGGAGC 588 17029 SNCA_ASO_00540 82 ACAACTGGCTAGCTATCCTT 589 17504 SNCA_ASO_00541 77 CACAACTGGCTAGCTATCCT 590 17505 SNCA_ASO_00542 89 ACACAACTGGCTAGCTATCC 591 17506 SNCA_ASO_00543 88 CACACAACTGGCTAGCTATC 592 17507 SNCA_ASO_00544 92 CAGAGGGTCCATAACACTCA 593 17667 SNCA_ASO_00545 91 TCAGAGGGTCCATAACACTC 594 17668 SNCA_ASO_00546 83 TGTGACCTGTGCTTGTTTGT 595 17747 SNCA_ASO_00547 79 TTGCCTGTGACCTGTGCTTG 596 17752 SNCA_ASO_00548 87 GTCAAGCACAAGGACAAGAA 597 17954 SNCA_ASO_00549 74 AGTCAAAGCACAAGGACAAGA 598 17955 SNCA_ASO_00550 70 AAGTCAAGCACAAGGACAAG 599 17956 SNCA_ASO_00551 78 GAAGTCAAAGCACAAGGACAA 600 17957 SNCA_ASO_00552 81 TGAAGTCAAGCACAAGGACA 601 17958 SNCA_ASO_00553 76 TCTGAAGTCAAAGCACAAGGA 602 17960 SNCA_ASO_00554 99 GCAGTTTCTATCCCACTCATC 4 18926 SNCA_ASO_00555 98 ATGCAGTTCTATCCCACTCA 603 18928 SNCA_ASO_00556 80 AAGGAACAAGGGAAGTGCAC 604 18983 SNCA_ASO_00557 82 GAAGGAACAAGGGAAGTGCA 605 18984 SNCA_ASO_00558 83 TGAAGGAACAAGGGAAGTGC 606 18985 SNCA_ASO_00559 97 TCTGGCTCAGTATTCTTTGC 607 20158 SNCA_ASO_00560 92 CCCACATCTAAGCAGGAAGA 608 20258 SNCA_ASO_00561 71 CCATCATGCTGGATCAAACA 609 20946 SNCA_ASO_00562 89 GCCATCATGCTGGATCAAAC 610 20947 SNCA_ASO_00563 32 CTGGCCATCATGCTGGATCA 611 20950 SNCA_ASO_00564 86 TCACACTCCAACCCTGGGCA 612 21314 SNCA_ASO_00565 73 TTCACACTCCAACCCTGGGC 613 21315 SNCA_ASO_00566 63 CATTCACACTCCAACCCTGG 614 21317 SNCA_ASO_00567 68 TCATTCACACTCCAACCCTG 615 21318 SNCA_ASO_00568 95 GCAGATAAACCATCCACTT 11 22295 SNCA_ASO_00569 87 TGCAGATAAACCATCCACT 616 22296 SNCA_ASO_00570 92 TTGCAGATAAACCATCCACAC 8 22297 SNCA_ASO_00571 69 AGGCAGTTGTGGTAGGGGTT 617 22602 SNCA_ASO_00572 66 GGTGTTGTCTGAAAGCAGGA 618 22782 SNCA_ASO_00573 61 TGGTGTTGTCTGAAAGCAGG 619 22783 SNCA_ASO_00574 70 TTGGTGTTGTCTGAAAGCAG 620 22784 SNCA_ASO_00575 63 GGGAGAAGGGATTTTCAAGG 621 22882 SNCA_ASO_00576 89 AGTGCCAGACCCCTTTCATTA 9 22932 SNCA_ASO_00577 96 CCAAGTGCCAGACCCTTTCA 10 22935 SNCA_ASO_00578 79 TAGCATCCTTCCACACCATT 622 23408 SNCA_ASO_00579 93 AATAGCATCCTTCCACACCA 5 23410 SNCA_ASO_00580 94 CAATAGCATCCTTCCACACC 623 23411 SNCA_ASO_00581 89 CAATAGCATCCTTCCACACC 623 23412 SNCA_ASO_00582 55 AAATGCAAAATGGGCTTCAC 624 23563 SNCA_ASO_00583 82 TGCTTGTTGCCATGCTGGGG 625 23674 SNCA_ASO_00584 88 TGTGCTTGTTGCCATGCTGG 626 23676 SNCA_ASO_00585 79 TTGTGCTTGTTGCCATGCTG 627 23677 SNCA_ASO_00586 0 TTTGTGCTTGTTGCCATGCT 628 23678 SNCA_ASO_00587 88 TTTTGTGCTTGTTGCCATGC 629 23679 SNCA_ASO_00588 90 ATTTTGTGCTTGTTGCCATG 630 23680 SNCA_ASO_00589 59 ATGGATGGGTGGACAAATGG 631 24058 SNCA_ASO_00590 45 TGGATCAGATGGATGGGTGG 632 24066 SNCA_ASO_00591 75 ATGGATCAGATGGATGGGTG 633 24067 SNCA_ASO_00592 74 AATGGATCAGATGGATGGGT 634 24068 SNCA_ASO_00593 85 CTTGGGCTGGACTTTTTTGC 635 26606 SNCA_ASO_00594 67 GTCACTGGATGGTTGGGAGC 636 26998 SNCA_ASO_00595 64 GGTCACTGGATGGTTGGGAG 637 26999 SNCA_ASO_00596 70 AGGTCACTGGATGGTTGGGA 638 27000 SNCA_ASO_00597 61 GAGGTCACTGGATGGTTGGG 639 27001 SNCA_ASO_00598 55 AGAGGTCACTGGATGGTTGG 640 27002 SNCA_ASO_00599 78 TAAGAGGTCACTGGATGGTT 641 27004 SNCA_ASO_00600 70 GCAATGGAACACTGCTACAT 642 28023 SNCA_ASO_00601 70 TGCAATGGAACACTGCTACA 643 28024 SNCA_ASO_00602 68 TTGCAATGGAACACTGCTAC 644 28025 SNCA_ASO_00603 64 CTTGCAATGGAACACTGCTA 645 28026 SNCA_ASO_00604 64 TCTTGCAATGGAACACTGCT 646 28027 SNCA_ASO_00605 58 TTCTTGCAATGGAACACTGC 647 28028 SNCA_ASO_00606 63 CTTCTTGCAATGGAACACTG 648 28029 SNCA_ASO_00607 79 CCTCAAGCCATCTAGCTCAA 649 28593 SNCA_ASO_00608 73 CCCTCAAGCCATCTAGCTCA 650 28594 SNCA_ASO_00609 82 ACCCTCAAGCCATCTAGCTC 651 28595 SNCA_ASO_00610 69 GACCCTCAAGCCATCTAGCT 652 28596 SNCA_ASO_00611 86 TGACCCTCAAGCCATCTAGC 653 28597 SNCA_ASO_00612 71 ATGACCCTCAAGCCATCTAG 654 28598 SNCA_ASO_00613 88 CTATGACCCTCAAGCCATCT 655 28600 SNCA_ASO_00614 88 GCTATGACCCTCAAGCCATC 55 28601 SNCA_ASO_00615 66 CACCTTCAAACCCCTTTCAA 656 29753 SNCA_ASO_00616 74 TCACCTTCAAACCCCTTTCA 657 29754 SNCA_ASO_00617 83 ATCACCTTCAAACCCCTTTC 6 29755 SNCA_ASO_00618 69 AGGGATCACCTTCAAACCCC 658 29759 SNCA_ASO_00619 89 TGTTTTGCTGCTCGAATCAT 659 29794 SNCA_ASO_00620 54 TGAAGAACGAAGCAAGTTGT 660 30645 SNCA_ASO_00621 59 CTGAAGAACGAAGCAAGTTG 661 30646 SNCA_ASO_00622 60 AACTGAAGAACGAAGCAAGT 662 30648 SNCA_ASO_00623 70 CAACTAACCACGGCACAATT 56 30828 SNCA_ASO_00624 79 ACAACTAACCACGGCACAAT 663 30829 SNCA_ASO_00625 76 TACAACTAACCACGGCACAA 664 30830 SNCA_ASO_00626 87 GAGTTTTACCCAAGTGGCAC 665 33340 SNCA_ASO_00627 77 GGAGGAAAGTAAGGTCAGGT 666 34639 SNCA_ASO_00628 16 GGGAGGAAAGTAAGGTCAGG 667 34640 SNCA_ASO_00629 27 AGGGAGGAAAGTAAGGTCAG 668 34641 SNCA_ASO_00630 55 GAGGGAGGAAAGTAAGGTCA 669 34642 SNCA_ASO_00631 55 GGAGGGAGGAAAGTAAGGTC 670 34643 SNCA_ASO_00632 87 GAGTATTGTGTGTGCCCTTT 671 35204 SNCA_ASO_00633 74 TGAGTATTGTGTGTGCCCTT 672 35205 SNCA_ASO_00634 42 GGGAAGAGGAAAAGCTTGGA 673 35562 SNCA_ASO_00635 87 AGCAGAGATTATGGCAGAGA 674 36416 SNCA_ASO_00636 89 CACAAGTAGGCAGCACAGGT 675 37759 SNCA_ASO_00637 87 GCACAAGTAGGCAGCACAGG 676 37760 SNCA_ASO_00638 0 TGCACAAGTAGGCAGCACAG 677 37761 SNCA_ASO_00639 0 AGCAAGGAAACTACAGCCCA 678 38425 SNCA_ASO_00640 0 GCAATGGGATCCACCACCAGC 679 38484 SNCA_ASO_00641 5 AGCAATGGGATCCACCACAG 680 38485 SNCA_ASO_00642 0 CAGCAATGGGATCCACCACA 681 38486 SNCA_ASO_00643 0 GCAGCAATGGGATCCACCAC 682 38487 SNCA_ASO_00644 8 AAGTTTTGGAGTGGAGGAGT 683 38845 SNCA_ASO_00645 0 GGAAAATATGGGGGCAACAG 684 39851 SNCA_ASO_00646 87 GGGAAAATATGGGGGCAACA 685 39852 SNCA_ASO_00647 82 GGGGAAAATATGGGGGCAAC 686 39853 SNCA_ASO_00648 93 AGGGGAAAATATGGGGGCAA 687 39854 SNCA_ASO_00649 87 GAGGGGAAAATATGGGGGCA 688 39855 SNCA_ASO_00650 90 CACCAAACCAACCAGAGGGGA 689 39868 SNCA_ASO_00651 84 GCACCAACCAACCAGAGGGG 690 39869 SNCA_ASO_00652 65 AGCACCAACCAACCAGAGGG 691 39870 SNCA_ASO_00653 50 GAGCACCAACCAACCAGAGG 692 39871 SNCA_ASO_00654 32 CAAAAGGAAGCAACCCACT 693 40413 SNCA_ASO_00655 52 GGGTCTCACTAGCCTAAAGT 694 42636 SNCA_ASO_00656 43 GGGGTCTCACTAGCCTAAAG 695 42637 SNCA_ASO_00657 8 AGTGTGAGAGGAGCAAGCTG 696 45030 SNCA_ASO_00658 54 GAGTCTCCATGAGCAATGCT 697 45715 SNCA_ASO_00659 75 CATTCCCAAGAGACCCAGAT 698 45873 SNCA_ASO_00660 73 CCATTCCCAAGAGACCCAGA 699 45874 SNCA_ASO_00661 83 ACCACCTGAGAACACTGAAT 700 46764 SNCA_ASO_00662 83 GACCACCTGAGAACACTGAA 701 46765 SNCA_ASO_00663 71 AGACCACCTGAGAACACTGA 702 46766 SNCA_ASO_00664 76 GAGACCACCTGAGAACACTG 703 46767 SNCA_ASO_00665 68 AGAGACCACCTGAGAACACT 704 46768 SNCA_ASO_00666 62 TAGAGACCACCTGAGAACAC 705 46769 SNCA_ASO_00667 72 CTAGAGACCACCTGAGAACA 706 46770 SNCA_ASO_00668 91 TGCCCAACTTACAATTCTCC 707 46929 SNCA_ASO_00669 80 ACTGCCATTGACCCTCTGCTT 708 47247 SNCA_ASO_00670 85 CACTGCCATTGACCTCTGCT 709 47248 SNCA_ASO_00671 87 ACACTGCCATTGACCCTCTGC 710 47249 SNCA_ASO_00672 74 CCACTTCACCCCAGAATTCCT 711 47665 SNCA_ASO_00673 82 AAACACACTTCAGACCACAC 712 49443 SNCA_ASO_00674 79 AGCCGACATACATCTCCAAA 713 49732 SNCA_ASO_00675 73 TAGCCGACATACATCTCCAA 57 49733 SNCA_ASO_00676 91 GTCAATCAACTGCATCCAGA 714 50632 SNCA_ASO_00677 88 CTGTCAATCAACTGCATCCA 715 50634 SNCA_ASO_00678 88 GGCACTAGGAGACCCTGGGA 716 51765 SNCA_ASO_00679 83 CATGCATAAGCAGCCTGAGT 717 51841 SNCA_ASO_00680 78 GTCATCATGCATAAGCAGCC 718 51846 SNCA_ASO_00681 73 AACCCTTCTGTCATCATGCA 719 51855 SNCA_ASO_00682 96 TGGGAACCCTTCTGTCATCA 720 51859 SNCA_ASO_00683 97 AGGCAGGGCTAGACAAAATG 721 52064 SNCA_ASO_00684 97 GAGGCAGGGCTAGACAAAAT 722 52065 SNCA_ASO_00685 93 AGAGGCAGGGCTAGACAAAAA 723 52066 SNCA_ASO_00686 80 CAGAGGCAGGGCTAGACAAA 724 52067 SNCA_ASO_00687 61 GGCAATCAAGCCAAACAAAT 725 52765 SNCA_ASO_00688 90 ACCCTGCTAGCCAGAAGAGA 726 59374 SNCA_ASO_00689 96 AACCCTGCTAGCCAGAAGAG 727 59375 SNCA_ASO_00690 87 AAACCCTGCTAGCCAGAAGA 728 59376 SNCA_ASO_00691 73 AGACCTAGTTCCCCCTGCCCC 729 60164 SNCA_ASO_00692 91 GAGACCTAGTTCCCCCTGCCC 730 60165 SNCA_ASO_00693 87 CTGAGAGGGGTGCTTTTAAG 731 60196 SNCA_ASO_00694 69 TTCCTGAGAGGGGTGCTTTT 732 60199 SNCA_ASO_00695 52 TTTCCTGAGAGGGGTGCTTT 733 60200 SNCA_ASO_00696 73 CCATGAAGCTTAACCCTCTC 734 60572 SNCA_ASO_00697 48 CCCATGAAGCTTAACCCCTCT 735 60573 SNCA_ASO_00698 69 TCCCATGAAGCTTAACCCTC 736 60574 SNCA_ASO_00699 63 TTCCCATGAAGCTTAACCCT 737 60575 SNCA_ASO_00700 72 ACCCTGCTGATTTCCCATGA 738 60586 SNCA_ASO_00701 47 CTACCCTGCTGATTTCCCAT 739 60588 SNCA_ASO_00702 30 ACTACCCTGCTGATTTCCCA 740 60589 SNCA_ASO_00703 53 AACTACCCTGCTGATTTCCC 741 60590 SNCA_ASO_00704 90 CCTTTTGACCCTCTGTTTGC 742 62701 SNCA_ASO_00705 85 GCACAATGCTTGAGAAGGTG 743 63958 SNCA_ASO_00706 78 CAATGGGAGACAGGAGCTAA 744 64029 SNCA_ASO_00707 62 ACAATGGGAGACAGGAGCTA 745 64030 SNCA_ASO_00708 85 GACAATGGGAGACAGGAGCT 746 64031 SNCA_ASO_00709 77 AGACAATGGGAGACAGGAGC 747 64032 SNCA_ASO_00710 90 CAGACAATGGGAGACAGGAG 748 64033 SNCA_ASO_00711 83 TCAGACAATGGGAGACAGGA 749 64034 SNCA_ASO_00712 65 CTCAGACAATGGGAGACAGG 750 64035 SNCA_ASO_00713 77 CAGCTCTCCAGACAATGGGAG 751 64040 SNCA_ASO_00714 37 GCAGCTCTCCAGACAATGGGA 752 64041 SNCA_ASO_00715 70 GGCAGCTCTCAGACAATGGG 753 64042 SNCA_ASO_00716 77 ATATCCTAGTGGCAGCTCTC 754 64052 SNCA_ASO_00717 74 CCCACCTAGCCTTCTTATCT 755 64443 SNCA_ASO_00718 68 ACCCACCTAGCCTTCTTATC 756 64444 SNCA_ASO_00719 78 CACCCACCTAGCCTTCTTAT 757 64445 SNCA_ASO_00720 73 GCACCCACCTAGCCTTCTTA 758 64446 SNCA_ASO_00721 39 AGCACCCCACCTAGCCTTCTT 759 64447 SNCA_ASO_00722 57 GAGCACCCACCTAGCCTTCT 760 64448 SNCA_ASO_00723 72 AGAGCACCCACCCTAGCCTTC 761 64449 SNCA_ASO_00724 77 GAGAGCACCCACCTAGCCTT 762 64450 SNCA_ASO_00725 78 CACAAAAGCAGATTGCCAGCA 763 64943 SNCA_ASO_00726 81 TCATAGATTTCCAAGGCTGC 764 65064 SNCA_ASO_00727 79 CCAAAACTGCAACAGACCCT 765 65429 SNCA_ASO_00728 84 TCCAAAACTGCAACAGACCC 766 65430 SNCA_ASO_00729 83 TTCCAAAACTGCAACAGACC 767 65431 SNCA_ASO_00730 82 TTCCCACTGCCTACCAGCCC 768 65642 SNCA_ASO_00731 87 CTTCCCACTGCCTACCAGCC 769 65643 SNCA_ASO_00732 75 CACACGAATGCACACACATG 770 65742 SNCA_ASO_00733 95 ACACACGAATGCACACACAT 771 65743 SNCA_ASO_00734 0 GACACACGAATGCACACACA 772 65744 SNCA_ASO_00735 1 GGACACACGAATGCACACAC 773 65745 SNCA_ASO_00736 4 CTCACCATTCCTCTGTACCT 774 66341 SNCA_ASO_00737 0 AAGGGAGGTCCTGAAACCAA 775 66718 SNCA_ASO_00738 0 CAAGGGAGGTCCTGAAACCA 776 66719 SNCA_ASO_00739 0 TAACCAACTTCTCAGAGCCCA 777 69419 SNCA_ASO_00740 0 TTAACCAACTCTCAGAGCCC 778 69420 SNCA_ASO_00741 6 CTTCCCTCAGCAACAGGCGC 779 69455 SNCA_ASO_00742 54 CCTCTTGCCTCCTGTCATTT 780 69612 SNCA_ASO_00743 65 GGAAGGACCTGCTGATCTAA 781 71345 SNCA_ASO_00744 95 GGGAAGGACCTGCTGATCTA 782 71346 SNCA_ASO_00745 83 AGGGAAGGACCTGCTGATCT 783 71347 SNCA_ASO_00746 67 GAGGGAAGGACCTGCTGATC 784 71348 SNCA_ASO_00747 76 GGAGGGAAGGACCTGCTGAT 785 71349 SNCA_ASO_00748 66 TGGAGGGAAGGACCTGCTGA 786 71350 SNCA_ASO_00749 79 GGAGATGCAGGGAAGAGTAA 787 71734 SNCA_ASO_00750 63 TGGAGATGCAGGGAAGAGTA 788 71735 SNCA_ASO_00751 93 AAGGGCAACTAACCAACAGA 789 71917 SNCA_ASO_00752 79 ATATCTGTAACCACGCCCTT 790 72246 SNCA_ASO_00753 76 CATATCTGTAACCACGCCCT 791 72247 SNCA_ASO_00754 70 ACATATCTGTAACCACGCCC 792 72248 SNCA_ASO_00755 63 AACATATCTGTAACCACGCC 793 72249 SNCA_ASO_00756 59 AATGCCCCACTAAGAAACCA 794 72621 SNCA_ASO_00757 69 AAATGCCCCACTAAGAAACC 795 72622 SNCA_ASO_00758 76 GTTGTGGCTTTGATCTGGTT 796 73343 SNCA_ASO_00759 82 AGTTGTGGCTTTGATCTGGT 797 73344 SNCA_ASO_00760 90 CTCAAGGTGCCATATCTGAG 798 73362 SNCA_ASO_00761 89 TCTCAAGGTGCCATATCTGA 799 73363 SNCA_ASO_00762 94 CAGGGACTGACACAGAGACC 800 73481 SNCA_ASO_00763 97 CCAGGGACTGACACAGAGAC 801 73482 SNCA_ASO_00764 79 GCCAGGGACTGACACAGAGA 802 73483 SNCA_ASO_00765 76 AGCCAGGGACTGACACAGAG 803 73484 SNCA_ASO_00766 89 GGAAGTCAACTGCTGGAAAA 804 73895 SNCA_ASO_00767 91 TGGAAGTCAACTGCTGGAAA 805 73896 SNCA_ASO_00768 92 CTGGAAGTCAACTGCTGGAA 806 73897 SNCA_ASO_00769 92 ACTGGAAGTCAACTGCTGGA 807 73898 SNCA_ASO_00770 58 CACTGGAAGTCAACTGCTGG 808 73899 SNCA_ASO_00771 65 GCACTGGAAGTCAACTGCTG 809 73900 SNCA_ASO_00772 72 TGCACTGGAAGTCAACTGCT 810 73901 SNCA_ASO_00773 71 TTGCACTGGAAGTCAACTGC 811 73902 SNCA_ASO_00774 92 GCTACCATGCTACATTGCTC 812 76048 SNCA_ASO_00775 92 GGCTACCATGCTACATTGCT 813 76049 SNCA_ASO_00776 90 TGTGTGCTTTGATATGGCTT 814 76506 SNCA_ASO_00777 86 CTTTGGTCTGTGCTGGCTGC 815 76797 SNCA_ASO_00778 86 ACTTTGGTCTGTGCTGGCTG 816 76798 SNCA_ASO_00779 88 CAAAACTGTCAACTCTGCCA 817 78391 SNCA_ASO_00780 86 CCAAAACTGTCAACTCTGCC 818 78392 SNCA_ASO_00781 84 CTCTTCAGCCCTAGTCTCTT 819 78999 SNCA_ASO_00782 78 TCTCTTCAGCCCTAGTCTCT 820 79000 SNCA_ASO_00783 56 GCTAATGGGCAAGCAAAAAA 821 79504 SNCA_ASO_00784 73 AGCTAATGGGCAAGCAAAAA 822 79505 SNCA_ASO_00785 69 GGGAGGGTAGGCTTTGACAA 823 96843 SNCA_ASO_00786 82 GGGGAGGGTAGGCTTTGACA 824 96844 SNCA_ASO_00787 74 TGGGGAGGGTAGGCTTTGAC 825 96845 SNCA_ASO_00788 86 GTGGGGAGGGTAGGCTTTGA 826 96846 SNCA_ASO_00789 90 AGTGGGGAGGGTAGGCTTTG 827 96847 SNCA_ASO_00790 84 CAGTGGGGAGGGTAGGCTTT 828 96848 SNCA_ASO_00791 50 TCAGTGGGGAGGGTAGGCTT 829 96849 SNCA_ASO_00792 54 AATCAGTGGGGAGGGTAGGC 830 96851 SNCA_ASO_00793 61 AAATCAGTGGGGAGGGTAGG 831 96852 SNCA_ASO_00794 68 GAAATCAGTGGGGAGGGTAG 832 96853 SNCA_ASO_00795 45 AGAAATCAGTGGGGAGGGTA 833 96854 SNCA_ASO_00796 34 GAGAAATCAGTGGGGAGGGT 834 96855 SNCA_ASO_00797 36 TGAGAAATCAGTGGGGAGGG 835 96856 SNCA_ASO_00798 30 GTGAGAAATCAGTGGGGAGG 836 96857 SNCA_ASO_00799 25 GGTGAGAAATCAGTGGGGAG 837 96858 SNCA_ASO_00800 29 GGGTGAGAAATCAGTGGGGA 838 96859 SNCA_ASO_00801 5 AGATGGGTCAAGCTGAGAAA 839 97294 SNCA_ASO_00802 11 AAGATGGGTCAAGCTGAGAA 840 97295 SNCA_ASO_00803 28 GAAGATGGGTCAAGCTGAGA 841 97296 SNCA_ASO_00804 37 TGAAGATGGGTCAAGCTGAG 842 97297 SNCA_ASO_00805 30 GCAACAAGGCTGAGTGAAGA 843 98629 SNCA_ASO_00806 43 AACCTAGCAACAAGGCTGAG 844 98635 SNCA_ASO_00807 16 AAACCTAGCAACAAGGCTGA 845 98636 SNCA_ASO_00808 18 CAAACCTAGCAACAAGGCTG 846 98637 SNCA_ASO_00809 64 CCAAACCTAGCAACAAGGCT 847 98638 SNCA_ASO_00810 77 GCCAAACCTAGCAACAAGGC 848 98639 SNCA_ASO_00811 70 AGCCAAACCTAGCAACAAGG 849 98640 SNCA_ASO_00812 74 AAGCCAAAACCTAGCAACAAG 850 98641 SNCA_ASO_00813 73 GTTTGGTTGGCCTGACTTTA 851 98950 SNCA_ASO_00814 55 GGTTTGGTTGGCCTGACTTT 852 98951 SNCA_ASO_00815 54 AGGTTTGGTTGGCCTGACTT 853 98952 SNCA_ASO_00816 70 TAGGTTTGGTTGGCCTGACT 854 98953 SNCA_ASO_00817 67 TTAGGTTTGGTTGGCCTGAC 855 98954 SNCA_ASO_00818 77 TTTAGGTTTGGTTGGCCTGA 856 98955 SNCA_ASO_00819 83 TTTTAGGTTTGGTTGGCCTG 857 98956 SNCA_ASO_00820 76 GGGGAGTGTGTACATAGTGT 858 100147 SNCA_ASO_00821 74 AGGGGAGTGTGTACATAGTG 859 100148 SNCA_ASO_00822 75 GGCTGGTTGGTCTTTGGTAT 860 100872 SNCA_ASO_00823 78 AGGCTGGTTGGTCTTTGGTA 861 100873 SNCA_ASO_00824 46 CAGGGAAGTGAAAGTGAAGG 862 101514 SNCA_ASO_00825 73 GGAAACAGAAATGGCTGAGA 863 101709 SNCA_ASO_00826 73 AGGAAACAGAAATGGCTGAG 864 101710 SNCA_ASO_00827 85 TCTGCCCTTGCCAATGCCCT 865 104952 SNCA_ASO_00828 64 TTCTGCCCTTGCCAATGCCC 866 104953 SNCA_ASO_00829 33 ATCATTCTGCCCTTGCCAAT 867 104957 SNCA_ASO_00830 4 ATGGTAGGTGGGCAGAGAAG 868 104984 SNCA_ASO_00831 32 TATGGTAGGTGGGCAGAGAA 869 104985 SNCA_ASO_00832 3 TTATGGTAGGTGGGCAGAGA 870 104986 SNCA_ASO_00833 51 TTGCTCCTGTGATGCCTGGT 871 108008 SNCA_ASO_00834 70 TTTGCTCCTGTGATGCCTGG 872 108009 SNCA_ASO_00835 69 TTCCCACCCAGATCAACATT 873 108107 SNCA_ASO_00836 58 TTTCCCACCCAGATCAACAT 874 108108 SNCA_ASO_00837 55 TTTTCCCACCCAGATCAACA 875 108109 SNCA_ASO_00975 83 GTTTCAGCTAGGCAACTCAA 876 1061 SNCA_ASO_00976 47 CTGGGCCACACTAATCACTA 877 7580 SNCA_ASO_00977 72 GGGCCACACTAATCACTAGA 878 7578 SNCA_ASO_00978 83 CAGCTAGGCAACTCAATGTG 879 1057 SNCA_ASO_00979 68 TTCAGCTAGGCAACTCAATG 880 1059 SNCA_ASO_00980 84 GGAGAACAGTGGAGGAGAGT 881 12062 SNCA_ASO_00981 92 GGGGACACTCATCTAAGGAA 882 12035 SNCA_ASO_00982 55 TACAAGACAATTCCAGCCCA 883 2299 SNCA_ASO_00983 89 TACTGGGCCACACTAATCAC 884 7582 SNCA_ASO_00984 88 AGAACAGTGGAGGAGAGTGG 885 12060 SNCA_ASO_00985 81 AGAGAGGATCAGCCAGGCAC 886 22451 SNCA_ASO_00986 74 AGAGTGGAGGATGGGGACAC 887 12047 SNCA_ASO_00987 53 TCACTGGATGGTTGGGAGCA 888 26997 SNCA_ASO_00988 0 CACAGGGGCATATCAAAGTC 889 548 SNCA_ASO_00989 66 TACTCCCCAGATAAGCCTCA 890 11986 SNCA_ASO_00990 70 GCTTGGGCTGGACTTTTTG 891 26607 SNCA_ASO_00991 79 CCCCAGATAAGCCTCAGTCT 892 11982 SNCA_ASO_00992 76 CACTGGATGGTTGGGAGCAG 893 26996 SNCA_ASO_00993 78 CAAGTGCCAGACCCCTTTCAT 894 22934 SNCA_ASO_00994 88 TTGTTTTGCTGCTCGAATCA 895 29795 SNCA_ASO_00995 67 TGTGTCTATGCCTGTGGATG 896 914 SNCA_ASO_00996 46 GTGCATGTTTCTTCCACTCT 897 2343 SNCA_ASO_00997 45 TCCCCAGATAAGCCTCAGTC 898 11983 SNCA_ASO_00998 66 GGAGCACCAACCAACCAGAG 899 39872 SNCA_ASO_00999 58 AAGACACAATACCTGCCTTC 900 39991 SNCA_ASO_01000 94 AGAGGGTTCCAAAGGAGCAC 901 39885 SNCA_ASO_01001 83 AAGTGCCAGACCCTTTCATT 902 22933 SNCA_ASO_01002 83 TCCAAGTGCCAGACCCCTTTC 903 22936 SNCA_ASO_01003 69 GATTGTTTTGCTGCTCGAAT 904 29797 SNCA_ASO_01004 67 GTGTCTATGCCTGTGGATGA 905 913 SNCA_ASO_01005 94 TAGTTGCCACCAGAGAATGT 906 994 SNCA_ASO_01006 63 CTTGGTGTTGTCTGAAAGCA 907 22785 SNCA_ASO_01007 67 GCCAGATAAAACAAGGCCCT 908 26439 SNCA_ASO_01008 34 CAGCAGCAATGGGATCCACC 909 38489 SNCA_ASO_01009 49 TGAACTGTGCTTGGGGTTGT 910 22248 SNCA_ASO_01010 41 TGTACTGATTTGTGCCTGGC 911 38056 SNCA_ASO_01011 54 GATCACCTTCAAACCCCTTT 912 29756 SNCA_ASO_01012 16 AAGAGGTCACTGGATGGTTG 913 27003 SNCA_ASO_01013 95 ATTGTTTTGCTGCTCGAATC 914 29796 SNCA_ASO_01014 98 TAGGGATCACCTTCAAACCC 915 29760 SNCA_ASO_01015 73 TTGCACAAGTAGGCAGCACA 916 37762 SNCA_ASO_01016 63 CAGAGGGTTCCAAAGGAGCA 917 39886 SNCA_ASO_01017 83 GGCAGTTGTGGTAGGGGTTC 918 22601 SNCA_ASO_01018 17 TTGAACTGTGCTTGGGGTTG 919 22249 SNCA_ASO_01019 71 GAGGAAGAATGGGCAATGTG 920 949 SNCA_ASO_01020 72 TTGGGCTGGACTTTTTTTGCA 921 26605 SNCA_ASO_01021 25 TTCCAAGTGCCAGACCCTTT 922 22937 SNCA_ASO_01022 twenty three TGGGCTGGACTTTTTTGCAT 923 26604 SNCA_ASO_01023 60 CCCTTTTAGACCCCCTGAAGT 924 22474 SNCA_ASO_01024 80 AGCAGCAATGGGATCCACCA 925 38488 SNCA_ASO_01025 41 TCCCTTTTAGACCCCTGAAG 926 22475 SNCA_ASO_01026 95 TCCAAAGGAGCACCAACCAA 16 39878 SNCA_ASO_01027 98 AGAGGGGAAAATATGGGGGC 927 39856 SNCA_ASO_01028 36 GCAGAGAGGAGAACAGTGGA 928 12069 SNCA_ASO_01029 5 GAAAATATGGGGGCAACAGA 929 39850 SNCA_ASO_01030 0 GGGATCACCTTCAAACCCCT 930 29758 SNCA_ASO_01031 69 TAGAGGCTGACAAGGGTAAG 931 5404 SNCA_ASO_01032 86 ACAAGTAGGCAGCACAGGTT 932 37758 SNCA_ASO_01033 36 GTCTATGCCTGTGGATGAGA 933 911 SNCA_ASO_01034 61 GGCTGACAAGGGTAAGAGGG 934 5400 SNCA_ASO_01035 29 ATGGGGACACTCATCTAAGG 935 12037 SNCA_ASO_01036 70 GGATCACCTTCAAACCCTT 936 29757 SNCA_ASO_01037 86 AGGGTTCCAAAGGAGCACCA 937 39883 SNCA_ASO_01038 52 AGGCACTAGGAGACCCTGGG 938 51766 SNCA_ASO_01039 76 AGTGAACAGATTCCAGCAGA 939 36430 SNCA_ASO_01040 83 ACTGTGCTTGGGGTTGTTTC 940 22245 SNCA_ASO_01041 33 GGGTTCCAAAGGAGCACCAA 941 39882 SNCA_ASO_01042 95 GCAGCAGCAATGGGATCCAC 942 38490 SNCA_ASO_01043 58 GGGAACCCTTCTGTCATCAT 943 51858 SNCA_ASO_01044 69 GGAAGAGGAAAAGCTTGGAG 944 35561 SNCA_ASO_01045 86 CTGGGAACCCTTCTGTCATC 945 51860 SNCA_ASO_01046 93 GGCAGGGCTAGACAAAATGG 946 52063 SNCA_ASO_01047 20 ACCCTTCTGTCATCATGCAT 947 51854 SNCA_ASO_01048 51 CTCCCCAGATAAGCCTCAGT 948 11984 SNCA_ASO_01049 52 CAGATAAAACAAGGCCCTGA 949 26437 SNCA_ASO_01050 53 GGGCTGGACTTTTTTTGCATG 950 26603 SNCA_ASO_01051 92 TTTGCACAAGTAGGCAGCAC 951 37763 SNCA_ASO_01052 92 CTTTGAACTGTGCTTGGGGT 952 22251 SNCA_ASO_01053 20 AAGGACAAGAGGCTTTTCTCC 953 11490 SNCA_ASO_01054 76 GAACTGTGCTTGGGGTTGTT 954 22247 SNCA_ASO_01055 70 CTTTGCACAAGTAGGCAGCA 955 37764 SNCA_ASO_01056 56 GTCTGAGAGGAGTTACACCA 956 11966 SNCA_ASO_01057 40 AGGACAAGAGGCTTTCTCCT 957 11489 SNCA_ASO_01058 twenty four AGGAAGAATGGGCAATGTGT 958 948 SNCA_ASO_01059 85 AGTCTGAGAGGAGTTACACC 959 11967 SNCA_ASO_01060 86 GAGGGTTCCAAAGGAGCACC 960 39884 SNCA_ASO_01061 93 CCAGATAAAACAAGGCCCTG 961 26438 SNCA_ASO_01062 84 GCTGGGAGAGAAAAGCAGAG 962 39720 SNCA_ASO_01063 93 GTACTGATTTGTGCCTGGCA 963 38055 SNCA_ASO_01064 91 GCACTAGGAGACCCTGGGAC 964 51764 SNCA_ASO_01065 80 GTACTCCCCAGATAAGCCTC 965 11987 SNCA_ASO_01066 80 CAGAGGGGAAAATATGGGGG 966 39857 SNCA_ASO_01067 80 TGTGCTGAACACCCATTATG 967 7029 SNCA_ASO_01068 72 TCAAACGACAAATTCCAGCT 968 36118 SNCA_ASO_01069 67 GCTGACAAGGGTAAGAGGGA 969 5399 SNCA_ASO_01070 87 TCATCATGCATAAGCAGCCT 970 51845 SNCA_ASO_01071 39 AGCAGAGAGGAGAACAGTGG 971 12070 SNCA_ASO_01072 84 ATCATGCATAAGCAGCCTGA 972 51843 SNCA_ASO_01073 57 TTGTAGGTCATGGGAAGTCA 973 35808 SNCA_ASO_01074 89 TGTCATCATGCATAAGCAGC 974 51847 SNCA_ASO_01075 85 GAACCCTTCTGTCATCATGC 975 51856 SNCA_ASO_01076 80 TGTAGGTCATGGGAAGTCAT 976 35807 SNCA_ASO_01077 83 CATCATGCATAAGCAGCCTG 977 51844 SNCA_ASO_01078 61 TTTGAACTGTGCTTGGGGTT 978 22250 SNCA_ASO_01079 40 TACTGATTTGTGCCTGGCAT 979 38054 SNCA_ASO_01080 59 GTGGAGGATGGGGACACTCA 980 12044 SNCA_ASO_01081 89 AATTCCAAGTGCCAGACCCT 981 22939 SNCA_ASO_01082 70 TCATGCATAAGCAGCCTGAG 982 51842 SNCA_ASO_01083 64 ATGCATAAGCAGCCTGAGTC 983 51840 SNCA_ASO_01084 29 CTGACAAGGGTAAGAGGGAG 984 5398 SNCA_ASO_01085 84 AAGCCTGACATAGCCACACA 985 11450 SNCA_ASO_01086 85 TGCATAAGCAGCCTGAGTCT 986 51839 SNCA_ASO_01087 87 AAGAGGCTATTGAGCACCCT 987 12324 SNCA_ASO_01088 54 AAGCAGCCTGAGTCTTAGAT 988 51834 SNCA_ASO_01089 84 AGGCTTTAACATGTGCTGAA 989 7040 SNCA_ASO_01090 58 AGAGGAAGAATGGGCAATGT 990 950 SNCA_ASO_01091 88 GGAAGGACTTGGGTCTTACT 991 22765 SNCA_ASO_01092 53 GAAGAATGGGCAATGTGTCT 992 946 SNCA_ASO_01093 79 AGACAGGCACTAGGAGACCC 993 51770 SNCA_ASO_01094 77 ACTGATTTGTGCCTGGCATC 994 38053 SNCA_ASO_01095 84 CAGCAGAGATTATGGCAGAG 995 36417 SNCA_ASO_01096 83 ATTCCAAGTGCCAGACCCCTT 996 22938 SNCA_ASO_01097 69 AAGTAGGCAGCACAGGTTTT 997 37756 SNCA_ASO_01098 90 CTCAACTCAGGCTAGCTACT 998 36619 SNCA_ASO_01099 69 GGCTGGACTTTTTTTGCATGG 999 26602 SNCA_ASO_01100 50 AAAATATGGGGGCAACAGAG 1000 39849 SNCA_ASO_01101 67 GGAAGAATGGGCAATGTGTC 1001 947 SNCA_ASO_01102 73 TGTGAATCCATTTGTCCAGC 1002 64296 SNCA_ASO_01103 29 GCATAAGCAGCCTGAGTCTT 1003 51838 SNCA_ASO_01104 47 GTTCCAAAAGGAGCACCAACC 1004 39880 SNCA_ASO_01105 79 CCAACCAACCAGAGGGGAAA 1005 39866 SNCA_ASO_01106 75 GGCCTGGAGAATAGGGAGAG 1006 52353 SNCA_ASO_01107 79 GGAACCCTTCTGTCATCATG 1007 51857 SNCA_ASO_01108 71 CCTGGTGTGTGCAAACATGT 1008 35411 SNCA_ASO_01109 51 CCTTTGTTCCCACATCACAT 1009 7209 SNCA_ASO_01110 85 CAAGGAAACTACAGCCCAGA 1010 38423 SNCA_ASO_01111 58 CAGTTGTGGTAGGGGTTCTT 1011 22599 SNCA_ASO_01112 91 GAGGCTGACAAGGGTAAGAG 1012 5402 SNCA_ASO_01113 80 AGAGGCTATTGAGCACCCTT 1013 12323 SNCA_ASO_01114 55 AAGGAAACTACAGCCCAGAC 1014 38422 SNCA_ASO_01115 87 GGGGCTTTGAACTGTGCTTG 1015 22255 SNCA_ASO_01116 81 AGCCTGACATAGCCACACAG 1016 11449 SNCA_ASO_01117 65 TAGATTGTTTTGCTGCTCGA 1017 29799 SNCA_ASO_01118 55 AGGAAGGACTTGGGTCTTAC 1018 22766 SNCA_ASO_01119 96 TCTGGCTAGAAATGTAGGCA 1019 35620 SNCA_ASO_01120 70 CAATGGGATCCACCACAGCA 1020 38483 SNCA_ASO_01121 64 AGGGCCACAAATAGGTCTCT 1021 578 SNCA_ASO_01122 82 GCAGTTGTGGTAGGGGTTCT 1022 22600 SNCA_ASO_01123 69 CCTCTGGTGCCTCTAGTTTT 1023 59845 SNCA_ASO_01124 61 GGCTTTAACATGTGCTGAAC 1024 7039 SNCA_ASO_01125 86 AGGAGGGGGCTTTGAACTGT 1025 22260 SNCA_ASO_01126 17 TAAACCCTGCTAGCCAGAAG 1026 59377 SNCA_ASO_01127 33 ACCAACCAACCAGAGGGGAA 1027 39867 SNCA_ASO_01128 48 TCAACTCAGGCTAGCTACTT 1028 36618 SNCA_ASO_01129 58 GCCAGGCGAGAATTTGCTTT 1029 40020 SNCA_ASO_01130 60 CCCTGCTAGCCAGAAGAGAT 1030 59373 SNCA_ASO_01131 93 CAGAGAGGAGAACAGTGGAG 1031 12068 SNCA_ASO_01132 27 GCAAGGAAACTACAGCCCAG 1032 38424 SNCA_ASO_01133 49 GTTGCCACCAGAGAATGTGA 1033 992 SNCA_ASO_01134 25 GAGGCTATTGAGCACCCTTA 1034 12322 SNCA_ASO_01135 30 GGGGGCTTTGAACTGTGCTT 1035 22256 SNCA_ASO_01136 45 AACTGATGCCTTCTACCTCCA 1036 38134 SNCA_ASO_01137 68 GGAGGGGGCTTTGAACTGTG 1037 22259 SNCA_ASO_01138 87 GGCCAGAAACCACTTAGAAC 1038 53762 SNCA_ASO_01139 42 AGTTGCCACCAGAGAATGTG 1039 993 SNCA_ASO_01140 47 TTGCCACCAGAGAATGTGAA 1040 991 SNCA_ASO_01141 95 TAAATTCCAAGTGCCAGACC 1041 22941 SNCA_ASO_01142 81 ATGTACTGATTTGTGCCTGG 1042 38057 SNCA_ASO_01143 83 GGTTCCAAAGGAGCACCAAC 1043 39881 SNCA_ASO_01144 67 ACTAGCATGAGAGCACCCAC 1044 64458 SNCA_ASO_01145 85 GGACAAGAGGCTTTTCTCCTT 1045 11488 SNCA_ASO_01146 28 CAAGTAGGCAGCACAGGTTT 1046 37757 SNCA_ASO_01147 73 CTGACATAGCCACACAGCCC 1047 11446 SNCA_ASO_01148 94 CCTGACATAGCCACACAGCC 1048 11447 SNCA_ASO_01149 25 GTGTTGTCTGAAAGCAGGAA 1049 22781 SNCA_ASO_01150 42 AGGAGAGCATGTTATTCCCTT 1050 22489 SNCA_ASO_01151 80 AGATTGTTTTGCTGCTCGAA 1051 29798 SNCA_ASO_01152 69 AAATTCCAAGTGCCAGACCCC 1052 22940 SNCA_ASO_01153 54 TTCCAAAGGAGCACCAACCA 1053 39879 SNCA_ASO_01154 66 ACTCCAGTAACCACACAAT 1054 7301 SNCA_ASO_01155 62 GCTTTGAACTGTGCTTGGGG 1055 22252 SNCA_ASO_01156 66 CATAGATTTCCAAGGCTGCA 1056 65063 SNCA_ASO_01157 88 TAGGGCCACAAATAGGTCTC 1057 579 SNCA_ASO_01158 90 GGGCCACAAATAGGTCTCTT 1058 577 SNCA_ASO_01159 85 GCCACCAGAGAATGTGAAAA 1059 989 SNCA_ASO_01160 83 TCCAAGGCTGCAAAAAGCTAA 1060 65055 SNCA_ASO_01161 50 CAGGCAAGAGATCTGGCTAG 1061 35631 SNCA_ASO_01162 13 TTAGGGCCACAAATAGGTCT 1062 580 SNCA_ASO_01163 65 AGCATGAGAGCACCCCACCTA 1063 64455 SNCA_ASO_01164 96 ACATGGCCAGAAACCACTTA 1064 53766 SNCA_ASO_01165 61 AACATGTGCTGAACACCCAT 1065 7033 SNCA_ASO_01166 35 AGGCTGACAAGGGTAAGAGG 1066 5401 SNCA_ASO_01167 69 GATCTGTCCACCTTAGCCTC 1067 40073 SNCA_ASO_01168 71 TGTACTCCCCAGATAAGCCT 1068 11988 SNCA_ASO_01169 62 AAGCAGAGAGGAGAACAGTG 1069 12071 SNCA_ASO_01170 44 AGGAAACTACAGCCCAGACA 1070 38421 SNCA_ASO_01171 53 CCAGCAGAGATTATGGCAGA 1071 36418 SNCA_ASO_01172 84 ACAAGCAAAGTGACCAAGAG 1072 52148 SNCA_ASO_01173 74 AACTCCAGTAACCACCACAA 1073 7302 SNCA_ASO_01174 40 TTGTACTCCCCAGATAAGCC 1074 11989 SNCA_ASO_01175 64 CAAGCAAAGTGACCAAGAGA 1075 52147 SNCA_ASO_01176 36 AGAGGAGTTACACCATGTCA 1076 11961 SNCA_ASO_01177 56 AACAAAGCAAAGTGACCAAGA 1077 52149 SNCA_ASO_01178 77 ATAAACCCTGCTAGCCAGAA 1078 59378 SNCA_ASO_01179 37 AACTGTGCTTGGGGTTGTTT 1079 22246 SNCA_ASO_01180 56 CTTGGGTCTTACTCCCTGGT 1080 22758 SNCA_ASO_01181 89 TTAGAGGCTGACAAGGGTAA 1081 5405 SNCA_ASO_01182 59 GGCTTTGAACTGTGCTTGGG 1082 22253 SNCA_ASO_01183 twenty four CAGGAAGGACTTGGGTCTTA 1083 22767 SNCA_ASO_01184 30 GCTGAGGCACTGTGACCCTG 1084 23055 SNCA_ASO_01185 88 TGCCAGGCGAGAATTTGCTT 1085 40021 SNCA_ASO_01186 46 TCTATGCCTGTGGATGAGAG 1086 910 SNCA_ASO_01187 91 GAACTGATGCCTCTACCTCC 12 38135 SNCA_ASO_01188 88 GCATGAGAGCACCCACCTAG 1087 64454 SNCA_ASO_01189 91 CCTTGCCCAACTGGTCCTTT 1088 13414 SNCA_ASO_01190 83 TCCAGCAGAGATTATGGCAG 1089 36419 SNCA_ASO_01191 32 CCAGGCGAGAATTTGCTTTT 1090 40019 SNCA_ASO_01192 81 ATGGGAGACAGGAGCTAATG 1091 64027 SNCA_ASO_01193 66 TTCTGCGTATGGGCATCTCC 1092 64116 SNCA_ASO_01194 86 ACATGTGCTGAACACCCATT 1093 7032 SNCA_ASO_01195 73 TGCCTCTACCTCCAGCAAGC 1094 38128 SNCA_ASO_01196 52 TTTCTGCGTATGGGCATCTC 1095 64117 SNCA_ASO_01197 62 TGAACAGATTCCAGCAGAGA 1096 36428 SNCA_ASO_01198 67 TGTGTTTCAACTGTGGGCTT 1097 52452 SNCA_ASO_01199 50 CATGCCAGGCGAGAATTTGC 1098 40023 SNCA_ASO_01200 59 GAGAGGAAGAATGGGCAATG 1099 951 SNCA_ASO_01201 81 AGGACTTGGGTCTTACTCCC 1100 22762 SNCA_ASO_01202 65 GCTACTAGCATGAGAGCACC 1101 64461 SNCA_ASO_01203 76 ATGCCAGGCGAGAATTTGCT 1102 40022 SNCA_ASO_01204 51 AAGACAGGCACTAGGAGACC 1103 51771 SNCA_ASO_01205 40 GACATAGCCACACACAGCCAA 1104 11444 SNCA_ASO_01206 92 TCTCAACTCAGGCTAGCTAC 1105 36620 SNCA_ASO_01207 75 GGAAACCACAGTGCTATGAA 1106 37467 SNCA_ASO_01208 56 ACATAGCCACACAGCCCAAG 1107 11443 SNCA_ASO_01209 93 AGGGGGCTTTGAACTGTGCT 1108 22257 SNCA_ASO_01210 75 AGGAGTTACACCATGTCAGC 1109 11959 SNCA_ASO_01211 76 ATGGCCAGAAACCACTTAGA 1110 53764 SNCA_ASO_01212 64 CAGGAGAGCATGTTATCCCT 1111 22490 SNCA_ASO_01213 70 TGGCAGCTCTCAGACAATGG 1112 64043 SNCA_ASO_01214 88 GAAGGAACTCCAGTAACCAC 1113 7307 SNCA_ASO_01215 86 AGGCAAGAGATCTGGCTAGA 1114 35630 SNCA_ASO_01216 69 GTAGGCAGCACAGGTTTTCT 1115 37754 SNCA_ASO_01217 87 GGGCTTTGAACTGTGCTTGG 1116 22254 SNCA_ASO_01218 94 GTGAACAGATTCCAGCAGAG 1117 36429 SNCA_ASO_01219 64 GCTTCCCAAGAGTATCAGGA 1118 51200 SNCA_ASO_01220 78 GGAGCTTCCCAAGAGTATCA 1119 51203 SNCA_ASO_01221 65 GGCAAGAGATCTGGCTAGAA 1120 35629 SNCA_ASO_01222 58 CATGTGCTGAACACCCATTA 1121 7031 SNCA_ASO_01223 49 CTGGGAGAGAAAAGCAGAGA 1122 39719 SNCA_ASO_01224 69 AGCTTCCCAAGAGTATCAGG 1123 51201 SNCA_ASO_01225 67 GGACTTGGGTCTTACTCCCT 1124 22761 SNCA_ASO_01226 36 GTGGCAGCTCTCAGACAATG 1125 64044 SNCA_ASO_01227 80 TGTCTATGCCTGTGGATGAG 1126 912 SNCA_ASO_01228 68 GGAGTTACACCATGTCAGCT 1127 11958 SNCA_ASO_01229 60 GACAGGCACTAGGAGACCCT 1128 51769 SNCA_ASO_01230 87 CCAAGGCTGCAAAAGCTAAA 1129 65054 SNCA_ASO_01231 89 CATGGCCAGAAACCACTTAG 1130 53765 SNCA_ASO_01232 91 AGTAGGCAGCACAGGTTTTTC 1131 37755 SNCA_ASO_01233 43 CCTGCTAGCCAGAAGAGATT 1132 59372 SNCA_ASO_01234 49 GCATGCCTTTGCTCACCTGT 1133 64278 SNCA_ASO_01235 65 TGAGAGGAGTTACACCATGT 1134 11963 SNCA_ASO_01236 94 ATGAGAGCACCCACCTAGCC 1135 64452 SNCA_ASO_01237 91 TGGGAGAGAAAAGCAGAGAT 1136 39718 SNCA_ASO_01238 71 GCCTGACATAGCCACACAGC 1137 11448 SNCA_ASO_01239 64 TAGCCACACAGCCAAGACC 1138 11440 SNCA_ASO_01240 28 AGCACAGGTTTTCTGACTTT 1139 37748 SNCA_ASO_01241 60 AATGGGAGACAGGAGCTAAT 1140 64028 SNCA_ASO_01242 85 TGCCACCAGAGAATGTGAAA 1141 990 SNCA_ASO_01243 61 TAGCATGAGAGCACCCACCT 1142 64456 SNCA_ASO_01244 73 ACTGATGCCTCTACCTCCAG 1143 38133 SNCA_ASO_01245 73 CATGAGAGCACCCCACCTAGC 1144 64453 SNCA_ASO_01246 86 CTAGCATGAGAGCACCCCACC 1145 64457 SNCA_ASO_01247 88 CCAGAGGGGAAAATATGGGG 1146 39858 SNCA_ASO_01248 66 GCCAAGCCCAAACACTAAGA 1147 59754 SNCA_ASO_01249 79 GGCTTGGGCTGGACTTTTTTT 1148 26608 SNCA_ASO_01250 76 TACTAGCATGAGAGCACCCA 1149 64459 SNCA_ASO_01251 42 TCCAATTAGCTGCCAGGAGT 1150 38527 SNCA_ASO_01252 58 AGCCAAGCCCAAACACTAAG 1151 59755 SNCA_ASO_01253 83 TGAGGCACTGTGACCCTGGG 1152 23053 SNCA_ASO_01254 84 CTACTAGCATGAGAGCACCC 1153 64460 SNCA_ASO_01255 85 TGAGAGCACCCCACCTAGCCT 1154 64451 SNCA_ASO_01256 73 TGGAAACCACAGTGCTATGA 1155 37468 SNCA_ASO_01257 77 GTTGTCTGAAAGCAGGAAGG 1156 22779 SNCA_ASO_01258 83 GTGTTTCAACTGTGGGCTTA 1157 52451 SNCA_ASO_01259 74 TGACATAGCCACACAGCCCA 1158 11445 SNCA_ASO_01260 73 CTGAACTGATGCCTCTACCT 1159 38137 SNCA_ASO_01261 75 TGAACTGATGCCTCTACCTC 1160 38136 SNCA_ASO_01262 76 CAGCACAGGTTTTCTGACTT 1161 37749 SNCA_ASO_01263 75 CCAGTGCCAAAAGTAAGAGGA 1162 64098 SNCA_ASO_01264 94 CTTTTTGGAGTTCTGGAGGC 1163 26625 SNCA_ASO_01265 78 ATCAGCTGAGGCACTGTGAC 1164 23059 SNCA_ASO_01266 61 TCTGTAGCCAAATGAATGGG 1165 52790 SNCA_ASO_01267 83 TAACATGTGCTGAACACCCA 1166 7034 SNCA_ASO_01268 41 ACCAGAGGGGAAAATATGGG 1167 39859 SNCA_ASO_01269 75 CTGATGCCTTACCTCCAGC 1168 38132 SNCA_ASO_01270 93 ACTGAACTGATGCCTCTACC 13 38138 SNCA_ASO_01271 87 AACGACAAAATTCCAGCTTCT 1169 36115 SNCA_ASO_01272 82 CATAGCCACACAGCCCAAGA 1170 11442 SNCA_ASO_01273 74 TTCCTGGAAACCACAGTGCT 1171 37472 SNCA_ASO_01274 46 TGGAGGATGGGGACACTCAT 1172 12043 SNCA_ASO_01275 87 AAGCCAAAGCCCAAACACTAA 15 59756 SNCA_ASO_01276 46 TAGCTAATGGGCAAGCAAAA 1173 79506 SNCA_ASO_01277 70 CCTAGTGGCAGCTCTCAGAC 1174 64048 SNCA_ASO_01278 81 TGGCCTGGAGAATAGGGAGA 1175 52354 SNCA_ASO_01279 89 TCAGCTGAGGCACTGTGACC 1176 23058 SNCA_ASO_01280 86 AACCAACCAGAGGGGAAAAT 1177 39864 SNCA_ASO_01281 63 ACAGGAGAGCATGTTATTCCC 1178 22491 SNCA_ASO_01282 54 CATTATCATGGTTGCCCAGA 1179 30187 SNCA_ASO_01283 76 CTTTCTGCGTATGGGCATCT 1180 64118 SNCA_ASO_01284 75 TTGACGGATCAGACACTCTT 1181 52860 SNCA_ASO_01285 73 TTTGACGGATCAGACACTCT 1182 52861 SNCA_ASO_01286 0 AACTACAGCCCAGACATGTC 1183 38417 SNCA_ASO_01287 75 TGGTGTGTGCAAACATGTAT 1184 35409 SNCA_ASO_01288 80 AGTGCCAAAGTAAGAGGAGA 1185 64096 SNCA_ASO_01289 94 ACCAACCAGAGGGGAAAATA 1186 39863 SNCA_ASO_01290 74 CTCCAATTAGCTGCCAGGAG 1187 38528 SNCA_ASO_01291 79 GCTGGACTTTTTTGCATGGA 1188 26601 SNCA_ASO_01292 81 TGGAGCTTCCCAAGAGTATC 1189 51204 SNCA_ASO_01293 73 TACCTTGCCCAACTGGTCCT 1190 13416 SNCA_ASO_01294 74 TGGCCAGAAACCACTTAGAA 1191 53763 SNCA_ASO_01295 34 TTTGCTTTCTGCGTATGGGC 1192 64122 SNCA_ASO_01296 69 TTTTGACGGATCAGACACTC 1193 52862 SNCA_ASO_01297 43 TATCCTAGTGGCAGCTCTCA 1194 64051 SNCA_ASO_01298 78 TCCTGGAAACCACAGTGCTA 1195 37471 SNCA_ASO_01299 59 ATAGCCACACAGCCCAAGAC 1196 11441 SNCA_ASO_01300 20 TGTTGTCTGAAAGCAGGAAG 1197 22780 SNCA_ASO_01301 85 TTCCAGCAGAGATTATGGCA 1198 36420 SNCA_ASO_01302 88 TTAACATGTGCTGAACACCC 1199 7035 SNCA_ASO_01303 78 TGACAAGGGTAAGAGGGAGG 1200 5397 SNCA_ASO_01304 84 CCTGGAAACCACAGTGCTAT 1201 37470 SNCA_ASO_01305 72 GGAAACTACAGCCCAGACAT 1202 38420 SNCA_ASO_01306 93 TACATGGCCAGAAACCACTT 14 53767 SNCA_ASO_01307 65 CCTTCCTGCCTCACGGATGT 1203 59980 SNCA_ASO_01308 74 CCAATTAGCTGCCAGGAGTG 1204 38526 SNCA_ASO_01309 88 AAAAGGAACATCAAAGGCGC 1205 64232 SNCA_ASO_01310 twenty four CTGCTAGCCAGAAGAGATTG 1206 59371 SNCA_ASO_01311 66 TGATCTTGGGCAAAAGTGTG 1207 36390 SNCA_ASO_01312 65 GTTAGTGAGCCAAGGCCCAG 1208 96733 SNCA_ASO_01313 72 GACTTGGGTCTTACTCCCTG 1209 22760 SNCA_ASO_01314 84 AAGGACTTGGGTCTTACTCC 1210 22763 SNCA_ASO_01315 51 GAGGGGGCTTTGAACTGTGC 1211 22258 SNCA_ASO_01316 40 GAAACTACAGCCCAGACATG 1212 38419 SNCA_ASO_01317 42 GCCTCTACCTCCAAGCAAGCA 1213 38127 SNCA_ASO_01318 33 AGACATTCACTCTGTGCTCA 1214 30347 SNCA_ASO_01319 79 AGCTGAGGCACTGTGACCCT 1215 23056 SNCA_ASO_01320 63 CTTCCTGCCTCACGGATGTC 1216 59979 SNCA_ASO_01321 36 GTGAAGATGGGTCAAGCTGA 1217 97298 SNCA_ASO_01322 89 ACTTGTGACCTTCAGTACCA 1218 30266 SNCA_ASO_01323 50 AACAAGGCCCTGAGTAACAA 1219 26430 SNCA_ASO_01324 34 AAACAAGGCCCTGAGTAACA 1220 26431 SNCA_ASO_01325 83 CTGGCCTGGAGAATAGGGAG 1221 52355 SNCA_ASO_01326 50 CAAAAGGAACATCAAAAGGCG 1222 64233 SNCA_ASO_01327 64 GCAGCACAGGTTTTCTGACT 1223 37750 SNCA_ASO_01328 69 CTGGAAACCACAGTGCTATG 1224 37469 SNCA_ASO_01329 64 AAAATGCAGGTTTGTAGGGC 1225 101226 SNCA_ASO_01330 46 ACCTTGCCCAACTGGTCCTT 1226 13415 SNCA_ASO_01331 45 TCTGCGTATGGGCATCTCCA 1227 64115 SNCA_ASO_01332 25 TTCCTGCCTCACGGATGTCC 1228 59978 SNCA_ASO_01333 28 TTATCATGGTTGCCCAGAAG 1229 30185 SNCA_ASO_01334 29 GCCTGGAGAATAGGGAGAGA 1230 52352 SNCA_ASO_01335 92 CTAGTGGCAGCTCTCCAGACA 1231 64047 SNCA_ASO_01336 96 GATCTTGGGCAAAAGTGTGT 1232 36389 SNCA_ASO_01337 85 AAACTACAGCCCAGACATGT 1233 38418 SNCA_ASO_01338 50 ATGTACATGGCCAGAAACCA 1234 53770 SNCA_ASO_01339 75 TTTTGCTTTCTGCGTATGGG 1235 64123 SNCA_ASO_01340 71 CTGGTGTGTGCAAACATGTA 1236 35410 SNCA_ASO_01341 96 GGCAGCACAGGTTTTCTGAC 1237 37751 SNCA_ASO_01342 20 ATCCTAGTGGCAGCTCTCAG 1238 64050 SNCA_ASO_01343 88 TGTACATGGCCAGAAACCAC 1239 53769 SNCA_ASO_01344 75 TATGCTGTGCCTTTTTGCTT 1240 64135 SNCA_ASO_01345 65 TAAGCCAGAAACAGAAAGGC 1241 12151 SNCA_ASO_01346 51 TGATGCCTCTACCTCCAGCA 1242 38131 SNCA_ASO_01347 88 GGAGGGTAGGCTTTGACAAA 1243 96842 SNCA_ASO_01348 26 GGATGGATGAATGCATGGAT 1244 51892 SNCA_ASO_01349 40 AAAGACAGGCACTAGGAGAC 1245 51772 SNCA_ASO_01350 83 CAATTAGCTGCCAGGAGTGC 1246 38525 SNCA_ASO_01351 78 CAGCTGAGGCACTGTGACCC 1247 23057 SNCA_ASO_01352 35 ACTGGCCTGGAGAATAGGGA 1248 52356 SNCA_ASO_01353 93 GCTTTCTGCGTATGGGCATC 1249 64119 SNCA_ASO_01354 75 TCCTAGTGGCAGCTCTCAGA 1250 64049 SNCA_ASO_01355 78 GATGCCTCTACCTCCAGCAA 1251 38130 SNCA_ASO_01356 73 ACAAGGCCCTGAGTAACAAG 1252 26429 SNCA_ASO_01357 53 ATGCCTCTACCTCCAAGCAAG 1253 38129 SNCA_ASO_01358 5 CTGTAGCCAAATGAATGGGC 1254 52789 SNCA_ASO_01359 6 TGGGTGAGAAATCAGTGGGG 1255 96860 SNCA_ASO_01360 0 CTGAGGCACTGTGACCCTGG 1256 23054 SNCA_ASO_01361 7 CAAGTCCTGCCCTGCCACTC 1257 64423 SNCA_ASO_01362 10 CAGTGCCAAAAGTAAGAGGAG 1258 64097 SNCA_ASO_01363 5 AAAACAAGGCCCTGAGTAAC 1259 26432 SNCA_ASO_01364 0 AAGTCCTGCCCTGCCACTCT 1260 64422 SNCA_ASO_01365 0 AAGATTACCACCTGGGCACA 1261 59513 SNCA_ASO_01366 4 GCAGGTTTGTAGGGCCTTGT 1262 101221 Example 3: mRNA reduction after multiple doses of MOE-modified ASO in vitro

The selective utility of modified oligonucleotides complementary to human SNCA nucleic acid sequences in reducing the amount of SNCA mRNA was tested in vitro in primary cortical neurons. Neurons were treated with multiple doses (3 µM; ½ log dilution; 11 concentrations) of the indicated antisense oligonucleotides. This assay provides the in vitro cellular potency ( _pIC50 = -Log(IC50 ₎ ) and potency (observed delta inhibition (%)) of the indicated ASOs in neurons. In addition, the Hill coefficient (which is the slope of the straight line in the Hill plot) was measured to observe the shape of the dose-response curve for each ASO.

Each modified oligonucleotide listed in Table I, Table J and Table K is complementary to human SNCA nucleic acid sequence SEQ ID NO: 1 and/or SEQ ID NO: 3. The ASOs in Table J were designed to be complementary to introns in the SNCA mRNA sequence, while the ASOs in Tables I and K were designed to be complementary to exons in the SNCA mRNA sequence.

Each of the ASOs in Tables I, J, and K is a 5-10-5 MOE spacer. The gapmers are 20 nucleobases in length, with the central gap segment comprising ten 2'-deoxynucleosides and each of the flanking segments comprising five 2'-MOE nucleosides. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages.

SNCA_ASO_01617 in Table J is a 5-10-5 MOE spacer. The spacer is 20 nucleobases in length, with a central gap segment comprising ten 2' deoxynucleosides and flanking segments on either side of the 5' and 3' ends comprising five 2'-MOE nucleosides . All cytosines throughout each gapmer are 5-methylcytosines. Except for phosphodiester linkages between nucleosides 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18, all other internucleoside linkages are phosphorothioate linkages.

Each of the ASOs in Table L is a 3-2-10-2-3 LNA/MOE mixed spacer. The equal spacers are 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxy nucleosides and each flanking segment comprising three LNA nucleosides and two 2'-MOE nucleosides. Therefore, the ASO contains 3 LNA nucleosides, two 2'-MOE nucleosides, 10 2'-deoxynucleosides, two 2'-MOE nucleosides and 3 LNA nucleosides from 5' to 3'. All cytosines throughout each gapmer are 5-methylcytosines, except for linkages between nucleosides 2 and 3, 4 and 5, 16 and 17, and 18 and 19, which link phosphodiester (PO) linkages All other internucleoside linkages are phosphorothioate (PS) linkages.

Each of the ASOs listed in Table M is a 2-3-10-3-2 BNA/MOE spacer. The equal spacers are 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxy nucleosides and each flanking segment comprising two BNA nucleosides and three 2'-MOE nucleosides. Thus, each ASO comprises two BNA nucleosides, three 2'-MOE nucleosides, ten 2'-deoxynucleosides, three 2'-MOE nucleosides and two BNA nucleosides from 5' to 3'. All cytosines throughout each gapmer are 5-methylcytosines, except for linkages between nucleosides 3 and 4, 4 and 5, 16 and 17, and 17 and 18, which link phosphodiester (PO) linkages All other internucleoside linkages are phosphorothioate linkages.

The positions identified in Tables I, J, K, L and M correspond to the "initial site", that is, the 5 complementary to the gapmer in the human SNCA nucleic acid sequence SEQ ID NO: 1 and/or SEQ ID NO: 3 'Nucleosides. Table I: 5-10-5 MOE spacers complementary to SNCA RNA exons Compound name δ inhibition observed value (%) IC ₅₀ (M) nH (-) _pIC50 (-) unmodified sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 3 Position in SEQ ID NO: 1 SNCA_ASO_00038 115 1.89E-08 0.9 7.72 TCCTTTCATGAATACATCCA 253 2 2 SNCA_ASO_00039 94 2.66E-09 0.5 8.58 GTCCTTTCATGAATACATCC 254 3 3 SNCA_ASO_00040 102 2.68E-08 0.9 7.57 AGTCCTTTTCATGAATACATC 255 4 4 SNCA_ASO_00044 106 2.63E-09 0.4 8.58 CTCCTTGGCCTTTGAAAGTC 259 20 20 SNCA_ASO_00049 108 1.53E-08 0.8 7.81 ACTCCCTCCTTGGCCTTTGA 264 25 25 SNCA_ASO_00050 110 2.01E-08 0.8 7.7 AACTCCCTCCTTGGCCTTTG 265 26 26 SNCA_ASO_00054 88 2.58E-09 0.6 8.59 CCACAACTCCCTCCTTGGCC 269 30 30 SNCA_ASO_00056 121 6.74E-08 0.7 7.17 AGCCACAACTCCCTCCTTGG 271 32 32 SNCA_ASO_00057 108 3.08E-08 0.9 7.51 CAGCCACAACTCCCTCCTTG 272 33 33 SNCA_ASO_00058 117 3.22E-08 0.6 7.49 GCAGCCACAACTCCCTCCTT 273 34 34 SNCA_ASO_00080 97 1.08E-08 0.6 7.97 GCCACACCCTGTTTGGTTTT 295 61 61 SNCA_ASO_00087 110 5.49E-08 0.8 7.26 TGCTTCTGCCACACCCTGTT 302 68 68 SNCA_ASO_00089 105 5.03E-08 0.9 7.3 GCTGCTTCTGCCACACCCTG 304 70 70 SNCA_ASO_00090 101 7.72E-08 0.9 7.11 TGCTGCTTCTGCCACACCCT 305 71 71 SNCA_ASO_00091 103 2.04E-09 0.5 8.69 CTGCTGCTTCTGCCACACCC 306 72 72 SNCA_ASO_00106 106 6.75E-08 0.8 7.17 CCTCTTTTGTCTTTCCTGCT 321 87 87 SNCA_ASO_00116 113 4.62E-08 0.7 7.34 GCCTACATAGAGACACCCT 331 104 NA SNCA_ASO_00117 114 5.00E-08 0.9 7.3 AGCCTACATAGAGAACACCC 332 105 NA SNCA_ASO_00133 117 1.53E-08 0.6 7.81 CCACTCCCTCCTTGGTTTTG 348 126 7497 SNCA_ASO_00149 92 9.22E-08 0.5 7.04 TTTGTCACTTGCTCTTTGGT 364 175 13301 SNCA_ASO_00150 98 6.16E-08 0.6 7.21 ATTTGTCACTTGCTCTTTGG 365 176 13302 SNCA_ASO_00151 102 8.42E-08 0.4 7.07 CATTTGTCACTTGCTCTTTG 366 177 13303 SNCA_ASO_00152 99 2.81E-08 0.4 7.55 ACATTTGTCACTTGCTCTTT 367 178 13304 SNCA_ASO_00153 101 2.05E-08 0.4 7.69 AACATTTGTCACTTGCTCTT 368 179 13305 SNCA_ASO_00154 101 1.27E-08 0.6 7.89 CAACATTTGTCACTTGCTCT 369 180 13306 SNCA_ASO_00155 101 3.82E-09 0.4 8.42 TCCAACATTTGTCACTTGCT 370 182 13308 SNCA_ASO_00183 89 5.95E-08 0.6 7.23 CCCTCCACTGTCTTCTGGGC 398 232 13358 SNCA_ASO_00184 72 2.78E-08 0.8 7.56 TCCTCCCACTGTCTTCTGGG 399 233 13359 SNCA_ASO_00185 88 2.44E-09 0.6 8.61 CTCCTCTCACTGTCTTCTGG 400 234 13360 SNCA_ASO_00186 93 3.25E-09 0.7 8.49 GCTCCTCCCACTGTCTTCTG 401 235 13361 SNCA_ASO_00187 83 5.99E-09 0.8 8.22 TGCTCCCTCCACTGTCTTCT 402 236 13362 SNCA_ASO_00188 112 1.85E-09 0.7 8.73 CTGCTCCCTCCACTGTCTTC 403 237 13363 SNCA_ASO_00189 108 2.57E-09 0.9 8.59 CCCTGCTCCCTCCACTGTCT 404 239 13365 SNCA_ASO_00190 109 3.51E-09 0.7 8.45 TCCCTGCTCCCTCCACTGTC 405 240 13366 SNCA_ASO_00191 99 6.85E-08 0.7 7.16 CTCCCTGCTCCCTCACTGT 406 241 13367 SNCA_ASO_00192 108 1.10E-09 0.9 8.96 GCTCCCTGCTCCCTCCACTG 407 242 13368 SNCA_ASO_00193 109 2.80E-09 0.9 8.55 TGCTCCCTGCTCCCTCACT 408 243 13369 SNCA_ASO_00194 105 5.25E-09 0.6 8.28 ATGCTCCCTGCTCCCCTCCAC 409 244 13370 SNCA_ASO_00195 110 1.79E-09 0.5 8.75 AATGCTCCCTGCTCCCTCCA 410 245 13371 SNCA_ASO_00196 100 7.87E-08 0.7 7.1 CAATGCTCCCTGCTCCCTCC 411 246 13372 SNCA_ASO_00197 99 4.62E-09 0.7 8.34 GCAATGCTCCCTGCTCCCTC 412 247 13373 SNCA_ASO_00198 102 6.66E-09 0.6 8.18 TGCAATGCTCCCTGCTCCCT 413 248 13374 SNCA_ASO_00199 107 4.65E-09 0.5 8.33 CTGCAATGCTCCCTGCTCCC 414 249 13375 SNCA_ASO_00200 99 1.61E-08 0.6 7.79 GCTGCAATGCTCCCTGCTCC 415 250 13376 SNCA_ASO_00201 88 6.40E-08 0.6 7.19 TGCTGCAATGCTCCCTGCTC 416 251 13377 SNCA_ASO_00202 91 5.32E-08 0.8 7.28 CTGCTGCAATGCTCCCTGCT 417 252 13378 SNCA_ASO_00203 72 1.66E-08 1 7.78 GCTGCTGCAATGCTCCCTGC 418 253 13379 SNCA_ASO_00204 75 4.91E-08 1.2 7.31 GGCTGCTGCAATGCTCCCTG 419 254 13380 Table J: 5-10-5 MOE spacers complementary to SNCA RNA introns Compound name δ inhibition observed value (%) IC ₅₀ (M) nH (-) _pIC50 (-) unmodified sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_00523 114 1.36E-09 0.4 8.86 ATTTCACTCTCATGGTGCCT 573 14576 SNCA_ASO_00530 104 6.55E-09 0.6 8.19 GTACATGTTTCCCCTGTTGCT 580 15596 SNCA_ASO_00537 132 8.6E-09 0.9 8.06 CCGGTGCCATTACTCCCTTT 7 16401 SNCA_ASO_00554 101 7.86E-10 0.6 9.1 GCAGTTTCTATCCCACTCATC 4 18926 SNCA_ASO_00555 114 3.07E-09 0.7 8.51 ATGCAGTTCTATCCCACTCA 603 18928 SNCA_ASO_00559 104 4.31E-10 0.6 9.36 TCTGGCTCAGTATTCTTTGC 607 20158 SNCA_ASO_00560 105 2.81E-09 0.6 8.55 CCCACATCTAAGCAGGAAGA 608 20258 SNCA_ASO_00568 98 4.16E-09 0.7 8.38 GCAGATAAACCATCCACTT 11 22295 SNCA_ASO_00569 111 1.34E-08 0.7 7.88 TGCAGATAAACCATCCACT 616 22296 SNCA_ASO_00570 112 5.77E-09 0.7 8.24 TTGCAGATAAACCATCCACAC 8 22297 SNCA_ASO_00576 103 8.28E-09 0.6 8.08 AGTGCCAGACCCCTTTCATTA 9 22932 SNCA_ASO_00577 116 4.24E-09 0.7 8.37 CCAAGTGCCAGACCCTTTCA 10 22935 SNCA_ASO_00579 124 9.8E-10 0.5 9.01 AATAGCATCCTTCCACACCA 5 23410 SNCA_ASO_00580 102 3.12E-09 0.6 8.5 CAATAGCATCCTTCCACACC 623 23411 SNCA_ASO_00593 104 1.12E-08 0.5 7.95 CTTGGGCTGGACTTTTTTGC 635 26606 SNCA_ASO_00614 94 9.38E-10 0.5 9.03 GCTATGACCCTCAAGCCATC 55 28601 SNCA_ASO_00617 115 6.22E-09 0.8 8.21 ATCACCTTCAAACCCCTTTC 6 29755 SNCA_ASO_00619 119 3.18E-09 0.7 8.5 TGTTTTGCTGCTCGAATCAT 659 29794 SNCA_ASO_00635 95 1.54E-09 0.7 8.81 AGCAGAGATTATGGCAGAGA 674 36416 SNCA_ASO_00636 104 2.96E-09 1 8.53 CACAAGTAGGCAGCACAGGT 675 37759 SNCA_ASO_00637 97 1.84E-09 0.8 8.74 GCACAAGTAGGCAGCACAGG 676 37760 SNCA_ASO_00646 102 3.75E-07 0.9 6.42 GGGAAAATATGGGGGCAACA 685 39852 SNCA_ASO_00648 87 2.63E-07 1.6 6.58 AGGGGAAAATATGGGGGCAA 687 39854 SNCA_ASO_00650 86 9.8E-08 0.5 7.01 CACCAAACCAACCAGAGGGGA 689 39868 SNCA_ASO_00675 99 5.91E-10 0.8 9.23 TAGCCGACATACATCTCCAA 57 49733 SNCA_ASO_00682 98 1.44E-08 0.7 7.84 TGGGAACCCTTCTGTCATCA 720 51859 SNCA_ASO_00683 103 8.48E-08 0.7 7.07 AGGCAGGGCTAGACAAAATG 721 52064 SNCA_ASO_00684 106 2.41E-08 0.9 7.61 GAGGCAGGGCTAGACAAAAT 722 52065 SNCA_ASO_00685 94 8.21E-09 0.7 8.09 AGAGGCAGGGCTAGACAAAAA 723 52066 SNCA_ASO_00688 115 5.53E-08 0.5 7.26 ACCCTGCTAGCCAGAAGAGA 726 59374 SNCA_ASO_00689 83 1.88E-07 0.7 6.73 AACCCTGCTAGCCAGAAGAG 727 59375 SNCA_ASO_00710 113 3.98E-08 0.7 7.4 CAGACAATGGGAGACAGGAG 748 64033 SNCA_ASO_00733 82 5.05E-08 1 7.3 ACACACGAATGCACACACAT 771 65743 SNCA_ASO_00744 111 9.7E-08 1 7.01 GGGAAGGACCTGCTGATCTA 782 71346 SNCA_ASO_00763 90 9.43E-08 0.9 7.02 CCAGGGACTGACACAGAGAC 801 73482 SNCA_ASO_00789 50 3.16E-07 6.5 AGTGGGGAGGGTAGGCTTTG 827 96847 SNCA_ASO_00981 65 3.62E-07 8.3 6.44 GGGGACACTCATCTAAGGAA 882 12035 SNCA_ASO_00983 96 7.18E-08 0.6 7.14 TACTGGGCCACACTAATCAC 884 7582 SNCA_ASO_00984 52 1.47E-07 1.5 6.83 AGAACAGTGGAGGAGAGTGG 885 12060 SNCA_ASO_00994 111 7.75E-09 0.8 8.11 TTGTTTTGCTGCTCGAATCA 895 29795 SNCA_ASO_01000 102 3.99E-08 0.7 7.4 AGAGGGTTCCAAAGGAGCAC 901 39885 SNCA_ASO_01005 82 5.01E-08 0.8 7.3 TAGTTGCCACCAGAGAATGT 906 994 SNCA_ASO_01013 115 1.28E-08 0.9 7.89 ATTGTTTTGCTGCTCGAATC 914 29796 SNCA_ASO_01014 103 3.47E-08 0.9 7.46 TAGGGATCACCTTCAAACCC 915 29760 SNCA_ASO_01026 116 1.73E-08 0.8 7.76 TCCAAAGGAGCACCAACCAA 16 39878 SNCA_ASO_01027 83 1.02E-06 16.6 5.99 AGAGGGGAAAATATGGGGGC 927 39856 SNCA_ASO_01037 105 2.75E-08 0.8 7.56 AGGGTTCCAAAGGAGCACCA 937 39883 SNCA_ASO_01042 117 3.47E-08 0.4 7.46 GCAGCAGCAATGGGATCCAC 942 38490 SNCA_ASO_01046 91 2.89E-08 1.1 7.54 GGCAGGGCTAGACAAAATGG 946 52063 SNCA_ASO_01051 87 1.64E-08 1 7.79 TTTGCACAAGTAGGCAGCAC 951 37763 SNCA_ASO_01052 65 5.59E-08 1.4 7.25 CTTTGAACTGTGCTTGGGGT 952 22251 SNCA_ASO_01060 87 2.49E-08 0.9 7.6 GAGGGTTCCAAAGGAGCACC 960 39884 SNCA_ASO_01061 73 1.82E-07 0.7 6.74 CCAGATAAAACAAGGCCCTG 961 26438 SNCA_ASO_01063 111 1.51E-07 0.5 6.82 GTACTGATTTGTGCCTGGCA 963 38055 SNCA_ASO_01070 108 7.36E-09 0.6 8.13 TCATCATGCATAAGCAGCCT 970 51845 SNCA_ASO_01074 106 3.63E-08 0.4 7.44 TGTCATCATGCATAAGCAGC 974 51847 SNCA_ASO_01081 61 2.46E-07 0.4 6.61 AATTCCAAGTGCCAGACCCT 981 22939 SNCA_ASO_01086 106 1.66E-07 0.4 6.78 TGCATAAGCAGCCTGAGTCT 986 51839 SNCA_ASO_01087 90 5.45E-08 0.7 7.26 AAGAGGCTATTGAGCACCCT 987 12324 SNCA_ASO_01091 112 5.30E-08 0.6 7.28 GGAAGGACTTGGGTCTTACT 991 22765 SNCA_ASO_01098 106 4.10E-08 0.6 7.39 CTCAACTCAGGCTAGCTACT 998 36619 SNCA_ASO_01112 88 6.80E-08 0.6 7.17 GAGGCTGACAAGGGTAAGAG 1012 5402 SNCA_ASO_01115 102 9.77E-08 0.7 7.01 GGGGCTTTGAACTGTGCTTG 1015 22255 SNCA_ASO_01119 102 1.44E-08 0.9 7.84 TCTGGCTAGAAATGTAGGCA 1019 35620 SNCA_ASO_01131 73 2.55E-07 0.6 6.59 CAGAGAGGAGAACAGTGGAG 1031 12068 SNCA_ASO_01141 107 3.48E-08 0.6 7.46 TAAATTCCAAGTGCCAGACC 1041 22941 SNCA_ASO_01148 71 1.02E-07 0.8 6.99 CCTGACATAGCCACACAGCC 1048 11447 SNCA_ASO_01157 85 1.87E-07 0.5 6.73 TAGGGCCACAAATAGGTCTC 1057 579 SNCA_ASO_01158 90 9.36E-08 0.6 7.03 GGGCCACAAATAGGTCTCTT 1058 577 SNCA_ASO_01164 94 5.83E-08 0.5 7.23 ACATGGCCAGAAACCACTTA 1064 53766 SNCA_ASO_01181 107 7.65E-08 1.2 7.12 TTAGAGGCTGACAAGGGTAA 1081 5405 SNCA_ASO_01185 148 4.42E-08 0.7 7.35 TGCCAGGCGAGAATTTGCTT 1085 40021 SNCA_ASO_01187 136 5.41E-09 0.9 8.27 GAACTGATGCCTCTACCTCC 12 38135 SNCA_ASO_01188 133 6.10E-09 0.9 8.21 GCATGAGAGCACCCACCTAG 1087 64454 SNCA_ASO_01189 96 1.06E-08 0.9 7.98 CCTTGCCCAACTGGTCCTTT 1088 13414 SNCA_ASO_01206 117 6.23E-09 0.8 8.21 TCTCAACTCAGGCTAGCTAC 1105 36620 SNCA_ASO_01209 113 3.25E-08 0.6 7.49 AGGGGGCTTTGAACTGTGCT 1108 22257 SNCA_ASO_01214 107 3.70E-08 0.8 7.43 GAAGGAACTCCAGTAACCAC 1113 7307 SNCA_ASO_01218 115 2.07E-09 0.9 8.68 GTGAACAGATTCCAGCAGAG 1117 36429 SNCA_ASO_01230 100 7.91E-09 0.8 8.1 CCAAGGCTGCAAAAGCTAAA 1129 65054 SNCA_ASO_01231 97 1.01E-08 1.1 8 CATGGCCAGAAACCACTTAG 1130 53765 SNCA_ASO_01232 119 3.01E-09 1.2 8.52 AGTAGGCAGCACAGGTTTTTC 1131 37755 SNCA_ASO_01236 121 2.54E-08 1.1 7.6 ATGAGAGCACCCACCTAGCC 1135 64452 SNCA_ASO_01237 110 1.70E-08 0.7 7.77 TGGGAGAGAAAAGCAGAGAT 1136 39718 SNCA_ASO_01264 116 5.53E-09 0.7 8.26 CTTTTTGGAGTTCTGGAGGC 1163 26625 SNCA_ASO_01270 104 5.70E-09 0.7 8.24 ACTGAACTGATGCCTCTACC 13 38138 SNCA_ASO_01275 123 1.68E-08 0.7 7.78 AAGCCAAAGCCCAAACACTAA 15 59756 SNCA_ASO_01289 90 3.75E-08 0.6 7.43 ACCAACCAGAGGGGAAAATA 1186 39863 SNCA_ASO_01301 88 4.98E-08 0.6 7.3 TTCCAGCAGAGATTATGGCA 1198 36420 SNCA_ASO_01302 95 2.29E-08 0.2 7.64 TTAACATGTGCTGAACACCC 1199 7035 SNCA_ASO_01306 98 8.57E-09 0.6 8.07 TACATGGCCAGAAACCACTT 14 53767 SNCA_ASO_01309 94 3.54E-08 0.6 7.45 AAAAGGAACATCAAAGGCGC 1205 64232 SNCA_ASO_01322 94 5.10E-09 0.6 8.29 ACTTGTGACCTTCAGTACCA 1218 30266 SNCA_ASO_01335 92 3.33E-08 0.6 7.48 CTAGTGGCAGCTCTCCAGACA 1231 64047 SNCA_ASO_01336 80 9.10E-08 1.1 7.04 GATCTTGGGCAAAAGTGTGT 1232 36389 SNCA_ASO_01341 114 1.97E-08 0.9 7.71 GGCAGCACAGGTTTTCTGAC 1237 37751 SNCA_ASO_01343 121 8.78E-08 0.6 7.06 TGTACATGGCCAGAAACCAC 1239 53769 SNCA_ASO_01347 112 8.52E-08 1 7.07 GGAGGGTAGGCTTTGACAAA 1243 96842 SNCA_ASO_01353 117 1.03E-08 1 7.99 GCTTTCTGCGTATGGGCATC 1249 64119 SNCA_ASO_01617 103 1.77E-9 0.8 8.75 GTTTTCATCAATATCTGCAA 1264 46216 Table K: 5-10-5 MOE spacers complementary to SNCA RNA exons Compound name δ inhibition observed value (%) IC ₅₀ (M) nH (-) _pIC50 (-) unmodified sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_00838 71 3.74E-11 10.43 CGGTGCCATTACTCCCTTTC 17 16400 SNCA_ASO_00839 94 1.81E-10 0.5 9.74 GTAAATATGTCAGTCTCCCG 58 18540 SNCA_ASO_00840 112 1.03E-09 0.6 8.99 GGGTTCTCTAACGACAGTAG 59 25550 SNCA_ASO_00841 116 4.46E-09 0.4 8.35 GGGGTTCTCTAACGACAGTA 60 25551 SNCA_ASO_00842 109 1.72E-08 0.5 7.77 GGATGGGGTTCTCTAACGAC 61 25555 SNCA_ASO_00843 107 4.88E-09 0.7 8.31 GAGCGATCGGAAGCTCCCTG 62 27763 SNCA_ASO_00844 108 6.86E-09 0.6 8.16 AGAGCGATCGGAAGCTCCCT 63 27764 SNCA_ASO_00846 94 7.09E-10 0.6 9.15 GTTGCTATCTAGGGATCACC 64 29769 SNCA_ASO_00847 99 1.95E-09 0.7 8.71 GCGAAGGACTATAATAGG 65 33628 SNCA_ASO_00848 111 2.12E-09 0.9 8.67 GGTAACTTAGGACAAGGTCC 66 38957 SNCA_ASO_00849 102 2.42E-09 0.7 8.62 TTCACATAAAGTAGCCGCTA 67 40930 SNCA_ASO_00850 98 1.02E-09 0.9 8.99 ACTTCACATAAAGTAGCCGCGC 68 40932 SNCA_ASO_00852 93 3.67E-10 0.9 9.44 ATAGCCGACATACATCTCCA 69 49734 SNCA_ASO_00853 94 6.94E-10 0.8 9.15 GACGGATCAGACACTTCTTAC 70 52858 SNCA_ASO_00854 105 3.67E-08 0.9 7.44 TGCCTCACGGATGTCCGTGT 71 59974 SNCA_ASO_00855 80 6.28E-10 0.7 9.2 GCTCGAGATTAGTTCTTCCC 72 69469 SNCA_ASO_00856 90 3.14E-09 0.5 8.5 GCCACTAGTAGATGACAGTT 73 71531 SNCA_ASO_00857 98 3.05E-09 0.5 8.52 GATGGAATTTACCCCCTAGT 74 74726 SNCA_ASO_00858 86 2.53E-08 0.5 7.6 AGCAGAAGCATGCGGCTACC 75 76062 SNCA_ASO_00859 82 1.25E-09 0.6 8.9 GGTATCGTCATGGAATTTGG 76 N/A SNCA_ASO_00860 79 2.15E-07 0.6 6.67 GATCTAAGGACCCTCAACAA 77 N/A SNCA_ASO_00861 107 2.55E-08 0.8 7.59 GGATCTAAGGACCCTCAACA 78 N/A SNCA_ASO_00862 85 3.76E-10 0.5 9.42 ACTCTATCTTGAGGCACACC 79 N/A SNCA_ASO_00863 94 8.79E-09 0.5 8.06 CTGTTAATGTAGTAGGAGCA 80 N/A SNCA_ASO_00864 85 2.15E-08 0.7 7.67 ACTGTTAATGTAGTAGGAGC 81 N/A Table L: 3-2-10-2-3 LNA/MOE hybrid spacer Compound name δ inhibition observed value (%) IC ₅₀ (M) nH (-) _pIC50 (-) unmodified sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_01618 100 1.74E-09 0.8 8.76 GCAGTTTCTATCCCACTCATC 4 18926 SNCA_ASO_01619 126 1.21E-08 0.8 7.92 CCGGTGCCATTACTCCCTTT 7 16401 SNCA_ASO_01620 74 3.16E-09 12.2 8.5 CCAAGTGCCAGACCCTTTCA 10 22935 SNCA_ASO_01621 118 1.18E-09 0.9 8.93 TTGCAGATAAACCATCCACAC 8 22297 SNCA_ASO_01623 75 6.79E-10 1.2 9.17 AATAGCATCCTTCCACACCA 5 23410 SNCA_ASO_01626 113 3.94E-09 1.1 8.4 CGGTGCCATTACTCCCTTTC 17 16400 Table M: 2-3-10-3-2 BNA/MOE Hybrid Spacer Compound name δ inhibition observed value (%) IC ₅₀ (M) nH (-) _pIC50 (-) unmodified sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 SNCA_ASO_01608 74 1.11E-09 1.1 8.96 GCAGTTTCTATCCCACTCATC 4 18926 SNCA_ASO_01609 105 4.09E-08 0.7 7.39 CCGGTGCCATTACTCCCTTT 7 16401 SNCA_ASO_01610 95 2.74E-09 1.2 8.56 CCAAGTGCCAGACCCTTTCA 10 22935 SNCA_ASO_01611 115 4.63E-09 1 8.33 TTGCAGATAAACCATCCACAC 8 22297 SNCA_ASO_01612 93 2.24E-09 0.8 8.65 GCAGATAAACCATCCACTT 11 22295 SNCA_ASO_01613 87 8.49E-10 0.7 9.07 AATAGCATCCTTCCACACCA 5 23410 SNCA_ASO_01614 100 2.85E-09 0.8 8.54 AGTGCCAGACCCCTTTCATTA 9 22932 SNCA_ASO_01615 99 2.52E-09 1.1 8.6 ATCACCTTCAAACCCCTTTC 6 29755 SNCA_ASO_01616 97 1.16E-08 0.9 7.93 CGGTGCCATTACTCCCTTTC 17 16400 Example 4: Tolerance and utility of modified oligonucleotides complementary to human SNCA in hSNCA mice

Three-month-old hSNCA mice received a single bolus ICV injection of the modified oligonucleotides listed in the Instruction Table at a dose of 30 nmol. Each modified oligonucleotide is complementary to the human SNCA gene body nucleic acid sequence (SEQ ID NO: 1). The positions in the tables indicate the 5' nucleoside complementary to the oligonucleotide in the human nucleic acid sequence (SEQ ID NO: 1).

For tolerance studies, tolerance scores were expressed as Functional Observation Panel (FOB) scores one hour after injection.

For efficacy studies, most treatment groups consisted of three animals. Mice were sacrificed two or six weeks after injection, as indicated. Brain tissue was collected and the amount of hSNCA mRNA was measured as described above. Results are presented in the table as percent reduction in SNCA mRNA levels relative to the vehicle control group. A value of 0% reduction indicates that the compound has no effect. I. Tolerance of 5-10-5 MOE spacer (PS)

Each ASO in Table N is a 5-10-5 MOE gapmer as described above, wherein all cytosines in each gapmer are 5-methylcytosines and all internucleoside linkages are phosphorothioate (PS) linkage. Figure 4 is a bar graph comparing the tolerance of selected 5-10-5 MOE spacers. Compounds with FOB greater than ten were excluded from other analyses. The structure of SNCA_ASO_01617 is as described above. Table N: Tolerance of 5-10-5 MOE spacers in hSNCA mice Compound name unmodified sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 FOB (1h) SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6.25 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 3.3 SNCA_ASO_00038 TCCTTTCATGAATACATCCA 253 2 0 SNCA_ASO_00040 AGTCCTTTTCATGAATACATC 255 4 3 SNCA_ASO_00056 AGCCACAACTCCCTCCTTGG 271 32 14 SNCA_ASO_00057 CAGCCACAACTCCCTCCTTG 272 33 11 SNCA_ASO_00058 GCAGCCACAACTCCCTCCTT 273 34 4 SNCA_ASO_00080 GCCACACCCTGTTTGGTTTT 295 61 3 SNCA_ASO_00091 CTGCTGCTTCTGCCACACCC 306 72 8 SNCA_ASO_00116 GCCTACATAGAGACACCCT 331 N/A 3 SNCA_ASO_00162 ACTGCTGTCACACCCGTCAC 377 13337 5 SNCA_ASO_00165 GCTACTGCTGTCACACCCGT 380 13340 11 SNCA_ASO_00166 GGCTACTGCTGTCACACCCG 381 13341 8 SNCA_ASO_00186 GCTCCTCCCACTGTCTTCTG 401 13361 12 SNCA_ASO_00187 TGCTCCCTCCACTGTCTTCT 402 13362 8 SNCA_ASO_00189 CCCTGCTCCCTCCACTGTCT 404 13365 3 SNCA_ASO_00190 TCCCTGCTCCCTCCACTGTC 405 13366 9 SNCA_ASO_00194 ATGCTCCCTGCTCCCCTCCAC 409 13370 0 SNCA_ASO_00198 TGCAATGCTCCCTGCTCCCT 413 13374 7 SNCA_ASO_00199 CTGCAATGCTCCCTGCTCCC 414 13375 4 SNCA_ASO_00215 TCTTGCCCAACTGGTCCTTT 430 N/A 11 SNCA_ASO_00523 ATTTCACTCTCATGGTGCCT 573 14576 9 SNCA_ASO_00530 GTACATGTTTCCCCTGTTGCT 580 15596 9 SNCA_ASO_00537 CCGGTGCCATTACTCCCTTT 7 16401 1 SNCA_ASO_00554 GCAGTTTCTATCCCACTCATC 4 18926 0 SNCA_ASO_00555 ATGCAGTTCTATCCCACTCA 603 18928 2.33 SNCA_ASO_00559 TCTGGCTCAGTATTCTTTGC 607 20158 10 SNCA_ASO_00560 CCCACATCTAAGCAGGAAGA 608 20258 10.33 SNCA_ASO_00568 GCAGATAAACCATCCACTT 11 22295 4.33 SNCA_ASO_00569 TGCAGATAAACCATCCACT 616 22296 0.66 SNCA_ASO_00570 TTGCAGATAAACCATCCACAC 8 22297 1.66 SNCA_ASO_00576 AGTGCCAGACCCCTTTCATTA 9 22932 3.66 SNCA_ASO_00577 CCAAGTGCCAGACCCTTTCA 10 22935 4 SNCA_ASO_00579 AATAGCATCCTTCCACACCA 5 23410 0.33 SNCA_ASO_00580 CAATAGCATCCTTCCACACC 623 23411 1 SNCA_ASO_00593 CTTGGGCTGGACTTTTTTGC 635 26606 11 SNCA_ASO_00617 ATCACCTTCAAACCCCTTTC 6 29755 0.66 SNCA_ASO_00619 TGTTTTGCTGCTCGAATCAT 659 29794 10 PBS N/A N/A 0.3 SNCA_ASO_00635 AGCAGAGATTATGGCAGAGA 674 36416 10 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 3.3 SNCA_ASO_00636 CACAAGTAGGCAGCACAGGT 675 37759 12 SNCA_ASO_00637 GCACAAGTAGGCAGCACAGG 676 37760 14 SNCA_ASO_00646 GGGAAAATATGGGGGCAACA 685 39852 1 SNCA_ASO_00648 AGGGGAAAATATGGGGGCAA 687 39854 0.33 SNCA_ASO_00650 CACCAAACCAACCAGAGGGGA 689 39868 0.33 SNCA_ASO_00682 TGGGAACCCTTCTGTCATCA 720 51859 8 SNCA_ASO_00683 AGGCAGGGCTAGACAAAATG 721 52064 0 SNCA_ASO_00684 GAGGCAGGGCTAGACAAAAT 722 52065 11 SNCA_ASO_00685 AGAGGCAGGGCTAGACAAAAA 723 52066 9 SNCA_ASO_00688 ACCCTGCTAGCCAGAAGAGA 726 59374 10 SNCA_ASO_00689 AACCCTGCTAGCCAGAAGAG 727 59375 9 SNCA_ASO_00710 CAGACAATGGGAGACAGGAG 748 64033 11 SNCA_ASO_00733 ACACACGAATGCACACACAT 771 65743 4.66 SNCA_ASO_00744 GGGAAGGACCTGCTGATCTA 782 71346 10 SNCA_ASO_00763 CCAGGGACTGACACAGAGAC 801 73482 9 SNCA_ASO_00789 AGTGGGGAGGGTAGGCTTTG 827 96847 11 SNCA_ASO_00838 CGGTGCCATTACTCCCTTTC 17 16400 1.33 SNCA_ASO_00839 GTAAATATGTCAGTCTCCCG 58 18540 12 SNCA_ASO_00840 GGGTTCTCTAACGACAGTAG 59 25550 10 SNCA_ASO_00841 GGGGTTCTCTAACGACAGTA 60 25551 11 SNCA_ASO_00842 GGATGGGGTTCTCTAACGAC 61 25555 14 SNCA_ASO_00849 TTCACATAAAGTAGCCGCTA 67 40930 9 SNCA_ASO_00850 ACTTCACATAAAGTAGCCGCGC 68 40932 11 SNCA_ASO_00851 TAGCCGACATACATCTCCAA 57 49733 1 SNCA_ASO_00852 ATAGCCGACATACATCTCCA 69 49734 3 SNCA_ASO_00854 TGCCTCACGGATGTCCGTGT 71 59974 6 SNCA_ASO_00855 GCTCGAGATTAGTTCTTCCC 72 69469 4 SNCA_ASO_00856 GCCACTAGTAGATGACAGTT 73 71531 10 SNCA_ASO_00858 AGCAGAAGCATGCGGCTACC 75 76062 10 SNCA_ASO_00859 GGTATCGTCATGGAATTTGG 76 N/A 14 SNCA_ASO_00860 GATCTAAGGACCCTCAACAA 77 N/A 6 SNCA_ASO_00861 GGATCTAAGGACCCTCAACA 78 N/A 4.33 SNCA_ASO_00862 ACTCTATCTTGAGGCACACC 79 N/A 5 SNCA_ASO_01897 ATTCCTTTACACCCACT 1263 N/A 0.33 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 1.67 PBS N/A N/A 0.33 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6.33 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 3.67 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 5.67 SNCA_ASO_01617 GTTTTCATCAATATCTGCAA 1264 46216 0.67 II. Effect of 5-10-5 MOE Spacer (PS)

Each ASO listed in Table 0 is a 5-10-5 MOE gapmer as described above, wherein all cytosine residues in each gapmer are 5-methylcytosine and all internucleoside linkages are sulfur Phosphate linkages. Figure 4 is a bar graph comparing the efficacy of selected 5-10-5 MOE spacers. The structure of SNCA_ASO_01617 is as described above.

As shown below, several ASOs reduced the amount of human SNCA mRNA in mice two weeks after injection. Table O: Effects of 5-10-5 MOE spacers in hSNCA mice Compound name Unmodified ASO sequence (SEQ ID NO) SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 time after injection mRNA reduction% SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 67 SNCA_ASO_00537 CCGGTGCCATTACTCCCTTT 7 16401 2 weeks 45 SNCA_ASO_00554 GCAGTTTCTATCCCACTCATC 4 18926 2 weeks 70 SNCA_ASO_00555 ATGCAGTTCTATCCCACTCA 603 18928 2 weeks 55 SNCA_ASO_00568 GCAGATAAACCATCCACTT 11 22295 2 weeks 30 SNCA_ASO_00569 TGCAGATAAACCATCCACT 616 22296 2 weeks 20 SNCA_ASO_00570 TTGCAGATAAACCATCCACAC 8 22297 2 weeks twenty two SNCA_ASO_00576 AGTGCCAGACCCCTTTCATTA 9 22932 2 weeks 19 SNCA_ASO_00577 CCAAGTGCCAGACCCTTTCA 10 22935 2 weeks 42 SNCA_ASO_00579 AATAGCATCCTTCCACACCA 5 23410 2 weeks 43 SNCA_ASO_00580 CAATAGCATCCTTCCACACC 623 23411 2 weeks 39 SNCA_ASO_00617 ATCACCTTCAAACCCCTTTC 6 29755 2 weeks 30 PBS N/A 2 weeks 0 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 67 SNCA_ASO_00646 GGGAAAATATGGGGGCAACA 685 39852 2 weeks 11 SNCA_ASO_00648 AGGGGAAAATATGGGGGCAA 687 39854 2 weeks 6 SNCA_ASO_00650 CACCAAACCAACCAGAGGGGA 689 39868 2 weeks 0 SNCA_ASO_00733 ACACACGAATGCACACACAT 771 65743 2 weeks 11 SNCA_ASO_00838 CGGTGCCATTACTCCCTTTC 17 16400 2 weeks 42 SNCA_ASO_00851 TAGCCGACATACATCTCCAA 57 49733 2 weeks 54 SNCA_ASO_00852 ATAGCCGACATACATCTCCA 69 49734 2 weeks 58 SNCA_ASO_00855 GCTCGAGATTAGTTCTTCCC 72 69469 2 weeks 40 SNCA_ASO_00860 GATCTAAGGACCCTCAACAA 77 N/A 2 weeks 0 SNCA_ASO_00861 GGATCTAAGGACCCTCAACA 78 N/A 2 weeks 0 SNCA_ASO_00862 ACTCTATCTTGAGGCACACC 79 N/A 2 weeks 28 SNCA_ASO_01897 ATTCCTTTACACCCACT 1263 N/A 2 weeks 0 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 66 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 70 SNCA_ASO_01617 GTTTTCATCAATATCTGCAA 1264 46216 2 weeks 58.4 III. Tolerance of 3-2-10-2-3 LNA/MOE Hybrid Spacer (PS)

Each of the ASOs listed in Table P was a 3-2-10-2-3 LNA/MOE hybrid spacer, except SNCA_ASO_00033, which was a 5-10-5 MOE spacer as described above, and was used as a comparator. The LNA/MOE hybrid spacers are 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxynucleosides and each flanking segment comprising three LNA nucleosides and two 2'-MOE nucleosides glycosides. Therefore, the ASO contains 3 LNA nucleosides, two 2'-MOE nucleosides, 10 2'-deoxynucleosides, two 2'-MOE nucleosides and 3 LNA nucleosides from 5' to 3'. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages.

Another experiment to determine mRNA reduction was not performed for compounds 00937, 00938, 00941 and 00942 because they did not show promising FOB results. Mice treated with these compounds were sacrificed. Table P: Tolerance of 3-2-10-2-3 LNA/MOE mixed spacers in hSNCA mice Compound name Unmodified ASO sequence (SEQ ID NO) SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 FOB (1h) SNCA_ASO_00937 CCACGGCACAATTTGA 173 N/A 14 SNCA_ASO_00938 TACAACTAACCACGGC 174 N/A 11 SNCA_ASO_00941 TACTATTCTTACGTGGC 179 N/A 12 SNCA_ASO_00942 CACATAAAGTAGCCGCGC 182 N/A 12 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 1.67 PBS N/A 0.33 IV. 3-2-10-2-3 Tolerance of LNA/MOE Spacer (PS/PO)

Each of the ASOs listed in Table Q (except for comparator SNCA_ASO_00033) is a 3-2-10-2-3 LNA/MOE hybrid spacer. Figure 5 is a bar graph comparing the tolerance of selected 3-2-10-2-3 LNA/MOE hybrid spacers. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate (PS) linkages, except for nucleosides 2 and 3, 4 and 5, 16 and 17, and the linkage between 18 and 19 is outside of the phosphodiester (PO) linkage. Table Q: Tolerance of 3-2-10-2-3 LNA/MOE mixed spacers in hSNCA mice Compound name Unmodified ASO sequence (SEQ ID NO) SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 FOB (1h) SNCA_ASO_01618 GCAGTTTCTATCCCACTCATC 4 18926 0.67 SNCA_ASO_01619 CCGGTGCCATTACTCCCTTT 7 16401 3.33 SNCA_ASO_01620 CCAAGTGCCAGACCCTTTCA 10 22935 2.33 SNCA_ASO_01621 TTGCAGATAAACCATCCACAC 8 22297 0.33 SNCA_ASO_01622 GCAGATAAACCATCCACTT 11 22295 1 SNCA_ASO_01623 AATAGCATCCTTCCACACCA 5 23410 0.83 SNCA_ASO_01624 AGTGCCAGACCCCTTTCATTA 9 22932 1 SNCA_ASO_01625 ATCACCTTCAAACCCCTTTC 6 29755 1.33 SNCA_ASO_01626 CGGTGCCATTACTCCCTTTC 17 16400 1.33 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6.33 PBS N/A 0 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 3.67 SNCA_ASO_01823 GAACTGATGCCTCTACCTCC 12 38135 7.33 SNCA_ASO_01824 ACTGAACTGATGCCTCTACC 13 38138 5.67 SNCA_ASO_01825 TACATGGCCAGAAACCACTT 14 53767 2.67 SNCA_ASO_01826 AAGCCAAAGCCCAAACACTAA 15 59756 3.67 SNCA_ASO_01822 TCCAAAGGAGCACCAACCAA 16 39878 2 PBS N/A 0.67 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 5.67 PBS N/A N/A 0.67 V. 3-2-10-2-3 Tolerance of LNA/MOE Spacer (PS/PO)

Each of the ASOs listed in Table R is a 3-2-10-2-3 LNA/MOE spacer. All cytosines throughout each gapmer are 5-methylcytosines. All internucleoside linkages are phosphorothioate linkages, except the linkages between nucleosides 2 and 3, 4 and 5, and 16 and 17, which are phosphodiester linkages. Table R: Tolerance of 3-2-10-2-3-LNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 FOB (1h) SNCA_ASO_01818 GCAGTTTCTATCCCACTCATC 4 18926 2.33 SNCA_ASO_01819 TTGCAGATAAACCATCCACAC 8 22297 0 SNCA_ASO_01820 ATCACCTTCAAACCCCTTTC 6 29755 0.67 SNCA_ASO_01821 CCGGTGCCATTACTCCCTTT 7 16401 0.33 VI. 3-2-10-2-3 Tolerance of LNA/MOE Spacer (PS/PO)

Each of the ASOs listed in Table S is a 3-2-10-2-3 LNA/MOE spacer. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages, except nucleosides 2 and 3, 3 and 4, 4 and 5, and 16 and 17, and the linkage between 17 and 18 is outside the phosphodiester linkage. Table S: Tolerance of 3-2-10-2-3 LNA/MOE mixed spacers in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 FOB (1h) SNCA_ASO_01811 GCAGTTTCTATCCCACTCATC 4 18926 0.67 SNCA_ASO_01814 TTGCAGATAAACCATCCACAC 8 22297 0.33 SNCA_ASO_01815 ATCACCTTCAAACCCCTTTC 6 29755 0.67 SNCA_ASO_01817 CCGGTGCCATTACTCCCTTT 7 16401 1 VII. 3-2-10-2-3 Effect of LNA/MOE Spacer (PS/PO)

Each ASO listed in Table T (except for comparator SNCA_ASO_00033) is a 3-2-10-2-3 LNA/MOE hybrid spacer. Figure 5 is a bar graph comparing the efficacy of selected 3-2-10-2-3 LNA/MOE hybrid spacers. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages, except nucleosides 2 and 3, 4 and 5, 16 and 17, and The linkage between 18 and 19 is outside the phosphodiester linkage.

As shown below, several ASOs reduced the amount of human SNCA mRNA in mice two weeks after injection. Table T: Effect of 3-2-10-2-3 LNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 time after injection mRNA reduction% SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 66 PBS N/A N/A 2 weeks 0 SNCA_ASO_01618 GCAGTTTCTATCCCACTCATC 4 18926 2 weeks 56 SNCA_ASO_01619 CCGGTGCCATTACTCCCTTT 7 16401 2 weeks 20 SNCA_ASO_01620 CCAAGTGCCAGACCCTTTCA 10 22935 2 weeks 49 SNCA_ASO_01621 TTGCAGATAAACCATCCACAC 8 22297 2 weeks 46 SNCA_ASO_01622 GCAGATAAACCATCCACTT 11 22295 2 weeks 30 SNCA_ASO_01623 AATAGCATCCTTCCACACCA 5 23410 2 weeks 52 SNCA_ASO_01624 AGTGCCAGACCCCTTTCATTA 9 22932 2 weeks 26 SNCA_ASO_01625 ATCACCTTCAAACCCCTTTC 6 29755 2 weeks 54 SNCA_ASO_01626 CGGTGCCATTACTCCCTTTC 17 16400 2 weeks 26 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 70 SNCA_ASO_01824 ACTGAACTGATGCCTCTACC 13 38138 6 weeks 37 SNCA_ASO_01825 TACATGGCCAGAAACCACTT 14 53767 6 weeks 0 SNCA_ASO_01826 AAGCCAAAGCCCAAACACTAA 15 59756 6 weeks 6 SNCA_ASO_01822 TCCAAAGGAGCACCAACCAA 16 39878 6 weeks 48 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6 weeks 66 SNCA_ASO_01623 AATAGCATCCTTCCACACCA 5 23410 6 weeks 72.6 SNCA_ASO_01625 ATCACCTTCAAACCCCTTTC 6 29755 6 weeks 71.9 SNCA_ASO_01621 TTGCAGATAAACCATCCACAC 8 22297 6 weeks 63.4 VIII. 3-2-10-2-3 Effect of LNA/MOE Spacer (PS/PO)

Each ASO in Table U is a 3-2-10-2-3 LNA/MOE spacer. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages, except those between nucleosides 2 and 3, 4 and 5, and 16 and 17 The interlinkages are other than phosphodiester linkages.

As shown below, two weeks after injection, ASO reduced the amount of human SNCA mRNA in mice. Table U: Effect of 3-2-10-2-3 LNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 mRNA reduction% SNCA_ASO_01818 GCAGTTTCTATCCCACTCATC 4 18926 67.5 SNCA_ASO_01819 TTGCAGATAAACCATCCACAC 8 22297 57.4 SNCA_ASO_01820 ATCACCTTCAAACCCCTTTC 6 29755 62.2 SNCA_ASO_01821 CCGGTGCCATTACTCCCTTT 7 18602 50.8 IX. 3-2-10-2-3 Effect of LNA/MOE Spacer (PS/PO)

Each ASO in Table V is a 3-2-10-2-3 LNA/MOE spacer. All cytosine residues throughout each gapmer are 5-methylcytosine, and all internucleoside linkages are phosphorothioate linkages, except nucleosides 2 and 3, 3 and 4, 4 and 5 , 16 and 17, and the linkages between 17 and 18 are outside the phosphodiester linkage.

As shown below, two weeks after injection, ASO reduced the amount of human SNCA mRNA in mice. Table V: Effect of 3-2-10-2-3 LNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 mRNA reduction% SNCA_ASO_01811 GCAGTTTCTATCCCACTCATC 4 18926 24.2 SNCA_ASO_01814 TTGCAGATAAACCATCCACAC 8 22297 47 SNCA_ASO_01815 ATCACCTTCAAACCCCTTTC 6 29755 42.6 SNCA_ASO_01817 CCGGTGCCATTACTCCCTTT 7 18602 57.9 X. Tolerance of 2-3-10-3-2 BNA/MOE Spacer (PS/PO)

Each ASO listed in Table W (except for comparator SNCA_ASO_00033) is a 2-3-10-3-2 BNA/MOE spacer. Figure 6 is a bar graph comparing the tolerance of selected 2-3-10-3-2 BNA/MOE spacers. The spacers are 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxy nucleosides and each flanking segment comprising two BNA nucleosides and three 2'-MOE nucleosides. Thus, each ASO comprises two BNA nucleosides, three 2'-MOE nucleosides, ten 2'-deoxynucleosides, three 2'-MOE nucleosides and two BNA nucleosides from 5' to 3'. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages, except nucleosides 3 and 4, 4 and 5, 16 and 17, and The linkage between 17 and 18 is outside the phosphodiester linkage. Table W: Tolerance of 2-3-10-3-2 BNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 FOB (1h) SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 1.67 PBS N/A N/A 0.33 SNCA_ASO_01608 GCAGTTTCTATCCCACTCATC 4 18926 0.5 SNCA_ASO_01609 CCGGTGCCATTACTCCCTTT 7 16401 2 SNCA_ASO_01610 CCAAGTGCCAGACCCTTTCA 10 22935 3 SNCA_ASO_01611 TTGCAGATAAACCATCCACAC 8 22297 0.81 SNCA_ASO_01612 GCAGATAAACCATCCACTT 11 22295 1 SNCA_ASO_01613 AATAGCATCCTTCCACACCA 5 23410 0.33 SNCA_ASO_01614 AGTGCCAGACCCCTTTCATTA 9 22932 1 SNCA_ASO_01615 ATCACCTTCAAACCCCTTTC 6 29755 1.33 SNCA_ASO_01616 CGGTGCCATTACTCCCTTTC 17 16400 2.67 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6.33 PBS N/A N/A 0 SNCA_ASO_01790 GAACTGATGCCTCTACCTCC 12 38135 9 SNCA_ASO_01791 ACTGAACTGATGCCTCTACC 13 38138 6.33 SNCA_ASO_01792 TACATGGCCAGAAACCACTT 14 53767 2.67 SNCA_ASO_01793 AAGCCAAAGCCCAAACACTAA 15 59756 1 SNCA_ASO_01789 TCCAAAGGAGCACCAACCAA 16 39878 2 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 3.67 PBS N/A N/A 0.67 XI. 3-2-10-2-3 Effect of BNA/MOE Spacer (PS/PO)

Each ASO listed in Table X (except for comparator SNCA_ASO_00033) is a 3-2-10-2-3 BNA/MOE spacer. Figure 6 is a bar graph comparing the potency of selected 2-3-10-3-2 BNA/MOE spacers. The equal spacers are 20 nucleobases in length, with a central gap segment comprising ten 2'-deoxy nucleosides and each flanking segment comprising three BNA nucleosides and two 2'-MOE nucleosides. Thus, each ASO comprises three BNA nucleosides, two 2'-MOE nucleosides, ten 2'-deoxynucleosides, two 2'-MOE nucleosides and three BNA nucleosides from 5' to 3'. All cytosines throughout each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages, except nucleosides 3 and 4, 4 and 5, 16 and 17, and The linkage between 17 and 18 is outside the phosphodiester linkage.

As shown below, ASO significantly reduced the amount of human SNCA mRNA in mice as soon as two weeks post-injection. Table X: Effect of 2-3-10-3-2 BNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence SEQ ID NO of unmodified oligonucleotide Position in SEQ ID NO: 1 time after injection mRNA reduction% SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 66 PBS N/A N/A 2 weeks 0 SNCA_ASO_01608 GCAGTTTCTATCCCACTCATC 4 18926 2 weeks 67 SNCA_ASO_01609 CCGGTGCCATTACTCCCTTT 7 16401 2 weeks 27 SNCA_ASO_01610 CCAAGTGCCAGACCCTTTCA 10 22935 2 weeks 50 SNCA_ASO_01611 TTGCAGATAAACCATCCACAC 8 22297 2 weeks 58 SNCA_ASO_01612 GCAGATAAACCATCCACTT 11 22295 2 weeks 55 SNCA_ASO_01613 AATAGCATCCTTCCACACCA 5 23410 2 weeks 78 SNCA_ASO_01614 AGTGCCAGACCCCTTTCATTA 9 22932 2 weeks 49 SNCA_ASO_01615 ATCACCTTCAAACCCCTTTC 6 29755 2 weeks 44 SNCA_ASO_01616 CGGTGCCATTACTCCCTTTC 17 16400 2 weeks 50 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 2 weeks 70 SNCA_ASO_01791 ACTGAACTGATGCCTCTACC 13 38138 6 weeks 44.5 SNCA_ASO_01792 TACATGGCCAGAAACCACTT 14 53767 6 weeks 19.7 SNCA_ASO_01793 AAGCCAAAGCCCAAACACTAA 15 59756 6 weeks 6.7 SNCA_ASO_01789 TCCAAAGGAGCACCAACCAA 16 39878 6 weeks 37.7 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6 weeks 69.7 SNCA_ASO_01613 AATAGCATCCTTCCACACCA 5 23410 6 weeks 82.2 SNCA_ASO_01608 GCAGTTTCTATCCCACTCATC 4 18926 6 weeks 76.8 SNCA_ASO_01611 TTGCAGATAAACCATCCACAC 8 22297 6 weeks 43.5 SNCA_ASO_01612 GCAGATAAACCATCCACTT 11 22295 6 weeks 46.5 SNCA_ASO_00033 CCAACATTTGTCACTTGCTC 251 13307 6 weeks 65.9 Example 5: Tolerability, efficacy and biodistribution of multiple doses of modified oligonucleotides complementary to human SNCA in hSNCA mice

Three-month-old hSNCA mice received a single bolus ICV injection of the listed modified oligonucleotides at the doses described in the indicated table. hSNCA mice were divided into groups of six mice. For each experiment, a group of six mice received PBS as a negative control. For the tolerance study, the tolerance score was expressed as a Functional Observation of Board (FOB) score one hour after injection.

For efficacy studies, mice will be sacrificed four weeks post-injection, except numbers with an asterisk, where analysis is two weeks post-injection. Cortical brain tissue was collected and the amount of hSNCA mRNA was measured as described above and the amount of α-synuclein was measured by ELISA kit as described above. Results are presented in the table as percent reduction in the amount of SNCA mRNA and α-synuclein relative to the vehicle (PBS) control group. A value of 0% reduction indicates that the compound has no effect.

For biodistribution studies, the concentration of SNCA_ASO in the cortex of hSNCA mice was quantified by high performance liquid chromatography (HPLC) fluorescence. I. Tolerance and efficacy of multiple doses of 2-3-10-3-2 BNA/MOE, 3-2-10-2-3 LNA/MOE and 5-10-5 MOE spacer (PS/PO)

SNCA_ASO_01613 in Table Y is a 2-3-10-3-2 BNA/MOE gapmer as described above, wherein the internucleosides between nucleosides 3 and 4, 4 and 5, 16 and 17, and 17 and 18 The linkages are phosphodiester internucleoside linkages, the other internucleoside linkages are phosphorothioate internucleoside linkages, and each cytosine is 5-methylcytosine. SNCA_ASO_01625 in Table Z is a 3-2-10-2-3 LNA/MOE gapmer as described above, wherein the internucleosides between nucleosides 2 and 3, 4 and 5, 16 and 17, and 18 and 19 The linkage is associated with a phosphodiester internucleoside linkage, the remaining internucleoside linkage is associated with a phosphorothioate internucleoside linkage, and each cytosine is a 5-methylcytosine. SNCA_ASO_01617 (SEQ ID NO: 1264) in Table AA is a 5-10-5 MOE gapmer in which the central gap segment comprises ten 2' deoxynucleosides flanked by flanking segments on both 5' and 3' ends Contains five 2'MOE nucleosides. In SNCA_ASO_01617, all cytosines in each gapmer are 5-methylcytosines, and all internucleoside linkages are phosphorothioate linkages, except 2 and 3, 3 and 4, 4 and 5, Except for internucleoside linkages between positions 16 and 17, and 17 and 18, they are all phosphodiester linkages.

Figure 7 is a bar graph comparing the effects of SNCA_ASO_1613, SNCA_ASO_1617 and SNCA_ASO_1625 based on the expression of SNCA mRNA at different doses of 1, 5, 10, 30 or 100 nmol. Figure 8 is a bar graph comparing the effects of SNCA_ASO_1613, SNCA_ASO_1617 and SNCA_ASO_1625 based on the expression of alpha synuclein at different doses of 1, 5, 10, 30 or 100 nmol. Decreases in mRNA and protein levels were analyzed two weeks after injection. Table Y: Tolerability and efficacy of multiple doses of 2-3-10-3-2 BNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence Dose (nmol) FOB (1h) mRNA reduction% Protein reduction % ED50 (nmol) SNCA_ASO_01613 AATAGCATCCTTCCACACCA 1 0 0 17 8.75 5 0.83 30 27 10 0.2 56 55 30 0 80 55 100 0.33 92 58 Table Z: Tolerability and efficacy of multiple doses of 3-2-10-2-3 LNA/MOE mixed spacer in hSNCA mice Compound name unmodified ASO sequence Dose (nmol) FOB (1h) mRNA reduction% Protein reduction % ED50 (nmol) SNCA_ASO_01625 ATCACCTTCAAACCCCTTTC 1 0.67 5 15 19.28 5 1.17 17 32 10 0.33 31 33 30 0.17 61 48 100 1 74* 42* Table AA: Tolerability and efficacy of multiple doses of 5-10-5 MOE spacer in hSNCA mice Compound name unmodified ASO sequence Dose (nmol) FOB (1h) mRNA reduction% Protein reduction % ED50 (nmol) SNCA_ASO_01617 GTTTTCATCA ATATCTGCAA 1 0.67 6 0 34.97 5 0.17 8 3 10 0.5 twenty one twenty one 30 0.33 45 44 100 1.83 69 52 II. Analysis of dose effect of ASO concentration in cortex by ELISA

In Table AB, SNCA_ASO_01613 is a 2-3-10-3-2 BNA/MOE gapmer as described above with nucleosides between 3 and 4, 4 and 5, 16 and 17, and 17 and 18 Internucleoside linkages link phosphodiester internucleoside linkages, other internucleoside linkages link phosphorothioate internucleoside linkages, and each cytosine is 5-methylcytosine; SNCA_ASO_01625 is 3-2- as described above 10-2-3 LNA/MOE gapmer, where internucleoside linkages between nucleosides 2 and 3, 4 and 5, 16 and 17, and 18 and 19 link phosphodiester internucleoside linkages, other nucleosides The interlinkage is a phosphorothioate internucleoside linkage, and each cytosine is a 5-methylcytosine; and SNCA_ASO_01617 is a 5-10-5 MOE gapmer, wherein all of the 5-10-5 MOE gapmer All cytosine nucleobases are 5-methylcytosine as described above.

Figure 9 is a dot plot showing the amount of ASO per mg of cortex quantified by HPLC fluorescence after a single ICV injection of multiple doses. Table AB: Dose effect of ASO concentration in the cortex of hSNCA mice Compound name unmodified ASO sequence Dose (nmol) Cortical median ASO concentration (fmol/mg) SNCA_ASO_01613 AATAGCATCCTTCCACACCA 1 62.98 5 158.73 10 271.14 30 866.00 100 2244.38 SNCA_ASO_01625 ATCACCTTCAAACCCCTTTC 1 34 5 113.9 10 151.6 30 464.6 100 1935.9 SNCA_ASO_01617 GTTTTCATCA ATATCTGCAA 1 12.75 5 42.30 10 72.35 30 193.32 100 590.57 Example 6: Tolerance of Modified Oligonucleotides in Rats

Male Weinstar rats received a single intrathecal bolus injection of oligonucleotide at a dose of 2.5 mg. Dosing solutions were prepared using sterile saline syringes and nuclease-free centrifugation. The tube containing the ASO powder was centrifuged briefly, then the aCSF solution was added, and then re-centrifuged for 10 minutes to completely dissolve the ASO powder. The solution was vortexed for ~1 min, stored at 4°C and filtered through a 0.22 µm filter until use.

For the tolerance study, the tolerance score was expressed as the functional observation group (FOB) score at one hour, three hours and twenty-four hours after injection.

In Tables AC, the tolerability profiles of SNCA_ASO_01617 and SNCA_ASO_01613 in rats are compared at the 2.5 mg dose as a function of time. Table AC: Analysis of Tolerance Scores in Rats Compound name unmodified ASO sequence dose (mg) FOB (1h) FOB (3 hours) FOB (24h) SNCA_ASO_01617 GTTTTCATCAATATCTGCAA 2.5 4 0 0 SNCA_ASO_01613 AATAGCATCCTTCCACACCA 2.5 0.75 0 0 Artificial CSF - 1.67 0 0 Example 7: Duration of Effect of Multiple Doses of Modified Oligonucleotides in hSNCA Mice

Three-month-old hSNCA mice were divided into groups of five to six mice and received a single unilateral bolus injection of oligonucleotides SNCA_ASO_1613 or SNCA_ASO_1617 at two doses of 10 and 50 nmol as described in Table AD below. For each experiment, a group of three mice received PBS as a negative control.

For efficacy studies, mice were sacrificed at various time points (2-6-12-20 weeks) after injection. Cortical, cerebellar and striatal brain tissues were collected and the amount of hSNCA mRNA was measured by qRT-PCR as described above and the amount of alpha synuclein by ELISA kit as described above. Results are presented in the table as percent reduction in the amount of SNCA mRNA and alpha synuclein relative to the vehicle (PBS) control group. A value of 0% reduction indicates that the compound has no effect.

Figure 11 is a dot plot comparing 10 nmol and 50 nmol doses of SNCA-ASO-01617 and SNCA_ASO_01613 in the cortex based on the quantification of SNCA mRNA expression by qRT-PCR as described above.

Figure 12 is a dot plot comparing 10 nmol and 50 nmol doses of SNCA-ASO-01617 and SNCA_ASO_01613 in the cerebellum based on the quantification of SNCA mRNA expression by qRT-PCR as described above.

Figure 13 is a dot plot comparing 10 nmol and 50 nmol doses of SNCA-ASO-01617 and SNCA_ASO_01613 in the striatum based on SNCA mRNA expression quantified by qRT-PCR as described above. Table AD: PK/PD analysis at different time points in hSNCA mice ASO name unmodified ASO sequence Dose (nmol) time point (week) leather striatum cerebellum % mRNA reduction % hSNCA protein reduction % mRNA reduction % hSNCA protein reduction % mRNA reduction % hSNCA protein reduction SNCA_ASO_01613 AATAGCATCCTTCCACACCA 10 2 43 48 76 1 0 0 6 55 twenty three 72 78 twenty two 29 12 39 51 51 41 15 30 20 25 12 0 2 20 0 50 2 86 64 94 42 29 16 6 88 59 87 85 48 47 12 81 84 89 77 52 69 20 69 59 63 51 50 34 SNCA_ASO_01617 GTTTTCATCA ATATCTGCAA 10 2 26 33 47 10 0 2 6 20 7 30 48 15 0 12 14 2 0 0 0 3 20 0 32 17 15 0 0 50 2 63 51 65 25 4 0 6 49 15 55 66 33 39 12 30 40 twenty one 20 12 16 20 11 twenty three 0 0 20 0 Example 8: Pathological reduction of α-synuclein in vitro

As shown in Figure 14, at DIVO, primary neuronal cultures (35,000 cells per well) from hSNCA A53T mice as described above were cultured and then treated with 200 nM human α seven days after primary neuron culture (DIV7). -Synuclein prefabricated fibrils (PFF, from StressMarq Bioscience SPR-316) transfection and four (DIV4), seven (DIV7) or ten (DIV10) days after the primary neuronal culture with 6, 20, 60, 200 or 170 nM SNCA_ASO_01613 or SNCA_ASO_01617 treatment. A control with non-specific (Malat1) ASO was used. After 19 days of primary neuronal culture (DIV19), cells were lysed and the phosphorylated form of α-synuclein (pS129) was measured by using a commercial immunoassay kit (Cisbio, #6FSYNPEG) according to the manufacturer's instructions. ) to analyze α-synuclein pathology. This assay is based on a sandwich assay using two different specific antibodies, one specific for binding to the pS129 motif of α-synuclein and the other specific for recognizing the α-synuclein, with donor or acceptor Dye markers. It equates to specific binding and close proximity on phosphorylated α-synuclein to generate a FRET (fluorescence resonance energy transfer) signal proportional to the amount of protein.

Figure 15 is a bar graph representing the extent of α-synuclein pathology (phosphorylated form) in primary neuronal cultures as measured by a TR-FRET-based immunoassay. The amount of phosphorylated α-synuclein was normalized by the amount of α-tubulin and the values were related to vehicle (PBS) treated wells. Seeded neurons were treated at DIV7 with high doses (330 nM) of specific ASO (SNCA) or non-specific ASO (Malat1 ), as described in Tables AE below. Tables AE: Amounts of phosphorylated α-synuclein in primary neurons Compound name unmodified ASO sequence Duration of treatment (DIV) Dose (nM) Phosphorylated aSyn FRET ratio (relative to PBS, %) SNCA_ASO_01613 AATAGCATCCTTCCACACCA DIV7 330 1.18 SNCA_ASO_01617 GTTTTCATCA ATATCTGCAA DIV7 330 0.70 Malat1_ASO TGCCTTTAGG ATTCTAGACA DIV7 330 101.15

Figure 16 is a bar graph representing the extent (mean ± SEM) of α-synuclein pathology (phosphorylated form) in primary neuronal cultures as measured by TR-FRET-based immunoassay. The amount of phosphorylated α-synuclein was normalized by the amount of α-tubulin and the values were related to vehicle (PBS) treated wells. Dose-response effects were assessed in specific ASO-treated seeded neurons at four, seven or ten days as described in Tables AF. Table AF: Amount of phosphorylated α-synuclein in primary neurons Compound name unmodified ASO sequence Dose (nM) Phosphorylated aSyn FRET ratio (relative to PBS, %) DIV4 DIV7 DIV10 SNCA_ASO_01613 AATAGCATCCTTCCACACCA 6 19.26 16.13 51.67 20 6.84 10.89 38.02 60 1.59 4.90 30.51 200 0.20 0.75 20.58 SNCA_ASO_01617 GTTTTCATCA ATATCTGCAA 6 26.42 35.17 66.92 20 11.01 12.63 55.16 60 2.59 5.41 39.33 200 0.24 1.40 23.34

Figure 1 is a diagram showing the insertion of the human SNCA gene at the endogenous mouse SNCA locus in the hSNCA mouse model ( hSNCA ^+/+ ).

Figure 2A shows human α-synuclei in cortical tissue from hSNCA ^+/+ (n=5), hSNCA ^+/- (n=5) and hSNCA ^−/− (n=2) three-month-old mice Quantitative bar graph of protein ( hSNCA protein). The amount of α-synuclein was assessed by mass spectrometry and normalized to the amount of GADPH protein.

Figure 2B shows murine α-synuclein in the cortex of hSNCA ^+/+ (n=5), hSNCA ^+/- (n=5) and hSNCA ^−/− (n=2) three-month-old mice Quantitative bar graph of ( mSNCA protein). The amount of α-synuclein was assessed by mass spectrometry and normalized to the amount of GADPH protein.

Figure 2C shows human α in different brain regions (cortex, cerebellum, hippocampus, striatum, spinal cord) and peripheral organs (liver, spleen, kidney) in three-month-old hSNCA ^+/+ mice (n=5) - Bar graph of the amount of synuclein (hSNCA protein). The amount of alpha-synuclein was assessed by mass spectrometry and normalized to the amount of GADPH protein.

Figure 3 is a table showing the tolerance scoring system for mice utilized in the in vivo assays described herein.

Figure 4 is a bar graph showing the efficacy and tolerability of the indicated ASOs in mice. The left Y-axis and solid bars show the expression levels of SNCA mRNA expressed in mouse neurons in vivo two weeks after treatment with the indicated ASO relative to PBS-treated samples. The right Y-axis and black circles show the absolute functional observation group (FOB) scores observed in mice one hour after treatment with the indicated ASO.

Figure 5 is a bar graph showing the potency and tolerability of the indicated 3LNA-2MOE-10DNA-2MOE-3LNA spacer ASOs. The axes are depicted in Figure 4.

Figure 6 is a bar graph showing the potency and tolerability of the indicated 2BNA-3MOE-10DNA-3MOE-2BNA spacer ASOs. The axes are depicted in Figure 4.

Figure 7 is a bar graph showing the effects of SNCA_ASO_1613, SNCA_ASO_1617 and SNCA_ASO_1625 at doses of 1, 5, 10, 30 and 100 nmol. The left Y-axis and solid bars show the expression levels of SNCA mRNA expressed in mouse neurons in vivo, four weeks after treatment with the indicated ASOs, relative to PBS-treated samples.

Figure 8 is a bar graph showing the effects of SNCA_ASO_1613, SNCA_ASO_1617 and SNCA_ASO_1625 at doses of 1, 5, 10, 30 and 100 nmol. The left Y-axis and solid bars show the expression levels of α-synuclein expressed in in vivo mouse neurons four weeks after treatment with the indicated ASOs relative to PBS-treated samples.

Figure 9 is a dot plot showing the concentrations of SNCA_ASO_1613, SNCA_ASO_1617 and SNCA_ASO_1625 quantified by HPLC fluorescence in cortical homogenates four weeks after single injections on ASO at 1, 5, 10, 30 and 100 nmol.

Figure 10 is a table showing the tolerance scoring system for rats utilized in the in vivo assays described herein.

Figure 11 is a dot plot comparing 10 nmol and 50 nmol doses of SNCA_ASO_01617 and SNCA_ASO_01613 in the cortex based on SNCA mRNA expression quantified by qRT-PCR.

Figure 12 is a dot plot comparing 10 nmol and 50 nmol doses of SNCA_ASO_01617 and SNCA_ASO_01613 in the cerebellum based on SNCA mRNA expression quantified by qRT-PCR.

Figure 13 is a dot plot comparing 10 nmol and 50 nmol doses of SNCA_ASO_01617 and SNCA_ASO_01613 in the striatum based on SNCA mRNA expression quantified by qRT-PCR as described above.

Figure 14 is a diagram depicting the experimental protocol used to measure α-synuclein pathology in ASO-treated neuronal cultures.

Figure 15 is a bar showing the extent of α-synuclein pathology (phosphorylated form) in primary neuronal cultures treated with SNCA_ASO_01613, SNCA_ASO_01617 and the non-targeting control Malat1_ASO and measured using a TR-FRET-based immunoassay picture.

Figure 16 shows α-synuclein pathology in primary neuronal cultures treated with SNCA_ASO_01613 and measured (mean ± SEM) by using a TR-FRET-based immunoassay before, during and after PFF treatment ( Bar graph of the degree of phosphorylated form). PFF: Prefabricated fibrils of human α-synuclein.

         
           <![CDATA[ <110> LES LABORATOIRES SERVIER]]>
           <![CDATA[ <120> Antisense oligonucleotides for inhibiting α-synuclein expression]]>
           <![CDATA[ <130> 027628.TW002]]>
           <![CDATA[ <140> TW 111108274]]>
           <![CDATA[ <141> 2022-03-07]]>
           <![CDATA[ <150> 21315033.7]]>
           <![CDATA[ <151> 2021-03-08]]>
           <![CDATA[ <150> 21306123.7]]>
           <![CDATA[ <151> 2021-08-17]]>
           <![CDATA[ <160> 1264 ]]>
           <![CDATA[ <170> PatentIn version 3.5]]>
           <![CDATA[ <210> 1]]>
           <![CDATA[ <211> 109052]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Sapiens]]>
           <![CDATA[ <400> 1]]> 
           atggatgtat tcatgaaagg actttcaaag gccaaggagg gagttgtggc tgctgctgag 60 
           aaaaccaaac agggtgtggc agaagcagca ggaaagacaa aagagggtgt tctctatgta 120 
           ggtaggtaaa ccccaaatgt cagtttggtg cttgttcatg agtgatgggt taggataatc 180 
           aatactctaa atgctggtag ttctctctct tgattcattt ttgcatcatt gcttgtcaaa 240 
           aaggtggact gagtcagagg tatgtgtagg taggtgaatg tgaacgtgtg tattgagct 300 
           aatagtaaaa aatgcgactg tttgcttttc cagattttta attttgccct aatattttg 360 
           actttttaaa aatgaatgtt tctgtaccta cataattcta tttcagagaa cagttttaaa 420 
           aactcatagt cttttaaaaa ataatcaaga atattcttaa gaatcaaaat cattgatgga 480 
           tctgtgattt cttttaccat catgaaaaat gtttgtcaat tttaatccat tctgattttt 540 
           aaaatatgac tttgatatgc ccctgtgatg tgtataaaga gacctatttg tggccctaaa 600 
           atggaaagaa cagattagtc tttgatagag ttacttcatg tgatcatttg gtctctgtga 660 
           acactgagga cagagaaaag tgcttgaggg ctgctactaa tctctcagaa aatttgtat 720 
           agttcatcca tcaaatgaca cacataactaa aagaataaag aaattgatgc ttattaccta 780 
           cttgttccta aagttccacc ttggggtata cacccaaact ctgactctct tttctgtaac 840 
           ttgaactgta ttcaattgag tgttatttta caaaccactt tgaattcctt ggaaaagaat 900 
           agacacacac tctcatccac aggcatagac acacacactc aacacagaca cattgcccat 960 
           tcttcctctc ttctttctcc tctgagcttt ttcacattct ctggtggcaa ctatagcagt 1020 
           aagagtcaca ggatgaacag tcaggtggag gatgaccaca ttgagttgcc tagctgaaac 1080 
           atgtgctctg tctatgtctg caaagtgaaa gaaagctaca ctatctcttc aacatagatc 1140 
           agtgggggaa attttatact tgggatgatt tatatgaatg catctcatca aagttcacaa 1200 
           cacattttttttttcagttttttattttca gtttttagag tcagggcctt gctctgtcgc 1260 
           ccaggctgga ctgcagtgat gctatcatag ctcactgcat ccttgaattc ctgggctcaa 1320 
           gtcatgcccc cacctcagcc tcctgagtag ccaggattat aggcatgtgc cactgcctca 1380 
           ttatttagac ttttcttatg ttgacttaat cttcccacaa atcttcaatt aaattacttt 1440 
           ttttctacct taaaacatat tttcagaaag tcattgaaat agggtgttac aagaggaaaa 1500 
           aattgatgag ttaattttaa atattttatg aagtgtgaat tatacctttt tagatggaat 1560 
           ttggaatact gaatcagtga catgcagttt atcagtatct ttccgtttgt cctcagattt 1620 
           ccaagttctg caagcacaag ttgctttgac ttagttacct tttaactgtt cattgaaatc 1680 
           attttcaatg tctctcatgg catttaacac atagcacatt ctataaatta tttattggtt 1740 
           acatctgag ttctaattga gagttgaact tacacacaga atttaagata aaaaatgacc 1800 
           atgtgaagac acaatagtat agtccaggga ttggcaaaat tttgggtaag gaatcagata 1860 
           gcacgtattt taagccatga gatctatgtc ttggccaggt gccgtggctc aggtctttaa 1920 
           tcccagcact ttgagagccc gaggctggtg gatcacttga gcccaggggt ttgagaccag 1980 
           cctgggccac agggtgaaac cctgtgtgtcta caaacaacgc aaaaattagc cgggtatggt 2040 
           agcatgcacg tgtattgcca gctacccagg aggctgaggt aggaggatgg cttgagccat 2100 
           acagctcact gcagaggttg cagtgagccg agatcgagcc actgcactcc agcctgggtg 2160 
           gcagagtgat accctgtcta aaaaaaaaaaaaaaaaaaaa atctatgtct caattctgct 2220 
           gttgaagtgt gaaggtagtc ataaacaata actagtgtgg ctgtgttcca ataaaacttc 2280 
           atttatcaaa acaggtggtg ggctggaatt gtcttgtatg ttgtagcttg ctgactactg 2340 
           atagagtgga aagaacatgc actaatcaca caaaccaaag ttttagttga gactacatca 2400 
           cttatcacct ttagggtctt ggggaagcgt acttaacatc tctgagcatc acttccctga 2460 
           ttagtaaaaa atatgattta gaaaacttca actaccttgc agtttttgtg agaatgtcat 2520 
           aataagacag gacatatgaa taattgagca cacttttata tataggaacc atggttatta 2580 
           ttatcaaata aactctccaa cggaataatt actttgccaa cacgttttcc atttattctt 2640 
           ttatccttca ttacataact agtttgaaag gttggaggcg accaaagacc attttataat 2700 
           ttcacttatg gccgaagatg tttggtagaa gcctcataag aaaagtaatc tcattccttt 2760 
           ataagaatat acttttaaca actacttttt aactcattga ataactacct taatgatcag 2820 
           tgttattttt atgggttttg ttccctccat ttttgttatc tgcatacacc aattttcaat 2880 
           caacatactt caatttaata gacaaaaatt tcttcaaatg actcagaaat taattagatc 2940 
           taaatccaaa agcagaaaga tttaattatc tttatataat gctcagtaat ataaatgcaa 3000 
           taaatacaag aaaatgatga tctttgagtg tcttccaatg ccactctgct caataagcag 3060 
           cagtggccat cagtgaaatt gatagcaaat tctcaagtca aaatgtgctt cacctcacta 3120 
           agctgacaaa gtcaacataa catgcacaac agggataact gagttctcaa aactctcagg 3180 
           tattacttct gaccttcttc tccactctgt gctcttttga ggttgggaag acaagatagg 3240 
           gtgtgtgtgg gacacctccg ctcagggaag ccatcagctc tggtgtccct acagcattta 3300 
           taccttgcta gtcacataac cacttggcac ctattttgta ggtgtatgtt atcaattaca 3360 
           gattactcat aaattaaagg ctaaccatca attacagatt attagtaaat aattatgacc 3420 
           tcaaagaaca actgattggt ttgatacatg gtaaccttat gaggactctc atttatctcg 3480 
           tttttttaag ttatatacct atctctttgg ggttgcacta caaaaatata aaatatgttg 3540 
           cataagatat ttataaaaaa taattaatta taagttctag tggtgtggtt tagtggcatt 3600 
           cttttttttttctttttttc tgagataggg tctcaatctg tcacttcact ccaggctgaa 3660 
           gtgcagtggt gtgatctcgg ctcactgcaa cctccgcctc ctgggttcaa gttattctcc 3720 
           tgactcagcc tcctgagtag ctgaaattac aggcacgcac caccatgccc ggctaatttt 3780 
           tgtattttta gtagagatgg ggtttcacca tgttagccag gatggtctcg aactcctgat 3840 
           ctcatcatcc tccgacctcg gcctcccaaa atgctgggat tacaggcgtg agccattgca 3900 
           cccggcctag tggcattctt ttttaaaaat aaatttaatt gtgtatattt agggtatgca 3960 
           acatgatgct atcagataca ttagacacta aaaaattact atattgaagc aaattaatat 4020 
           attcataatc tctcatagtt accttttttg ttgtttttgt ggcaagggca gctaaaatcc 4080 
           acttattt catgaatctc aaatatagta caattttatc acctacagtc ctcatacatt 4140 
           agatctgtac acttgttcat cttacacatc tgctacttgc ttggatccta tggcctatat 4200 
           gtccctattt tctacctact tttccacccc tattaaccct gtattttacg tagtctctgt 4260 
           atatttgaat tttgtttcaa gcttccacat atatgtgaga taatgtaata tttttctttc 4320 
           tgtgtttggc ttatttcact tagcataatt ttgtctgggt tcatccatgt tgtaaatggt 4380 
           aggatcttgt ttttttaggg ctgactgata ttccattgta tctatgtacc acaatctttt 4440 
           tatctaccta tctatcagta gacactttag ttgtggctat tatgtttttc tttttttctt 4500 
           ttttggagac agggtcttgc tgtcacccag gctgcaatgg agtggtgtta tcatagctca 4560 
           ctgtaacctc aaacttctgg gctcaagaga tcctcctgcc ttggcctccc aagtagctgg 4620 
           gactacaggc atacattacc atgcctggct aatttttaat attttttgta gatatagcat 4680 
           ctcactctgt tgcccagact ggtctcaaac tcctaattca aatttagaat agagtatgac 4740 
           aattctgtaa aatataaaaa acatgtccac tccgtatagg aagttataca atgagaagaa 4800 
           gacaaacact atttacatta ctcttgataa gttttttaca aagaaataaa acactttaat 4860 
           ttctaatgtt ttaaattctg gtttgctaaa taaataaata ttagttttag tgtttttaaa 4920 
           attccttata tagttataag tgatcttcct gcctcagcct cccaaagcac tgggattcca 4980 
           agcaagagcc actgtgttgg ggcccttgga aacagatatg ctgaaatctt ttcttgtgga 5040 
           tctacaccca gaagagggat tgctgggtca tatgctactc tatttttaat ttttctttta 5100 
           tttttagtga atatgtaata attgtatata attgtgggat ccagaattat atttccatac 5160 
           atgtatacag tgtgtgataa tcaaattagg gtaattaaca tatccattac ctgaaacatt 5220 
           tatcattcct ttgtggtggg aacagtaaaa attaaaaatt ctctcttcta gatttttgaa 5280 
           catatgcaat aaactattgt taagtatatc accctacagt actacagaat gctagaactc 5340 
           attcctcata tttggctcca atttcatatt ctttaaccaa cctctccata tcctcccctc 5400 
           cctcttaccc ttgtcagcct ctaataatca taattctact ctctacttct atctcattgt 5460 
           ctttgattagg gaatatgttt cataatttaa ccaaaggtca aattcttagg tactgctaag 5520 
           gcaaagaaca aagatcgcat tccagctgtt agacatttct tactactagt catttttaag 5580 
           acaacatggg gtgcaggtgg tgaggatgag agatagagat tgaaacatat tctcttaaat 5640 
           atcagctgtt ctcactctgc atagttccag cacaaacaaa ttccaggtac tatggttagt 5700 
           taaataacac cagcccctaa caacacaatt caaatttctg ttaccacagt ataccgaaag 5760 
           tcattgcata aagtacaaac tttgctgcta actcttcagc cttcaaatca ttacataaat 5820 
           aacagaaacc catttataatc agtgacaaaa ccacagcact tctttcaaag ctttttggag 5880 
           attggttgct tcacatctgt tatgcagttc atacagacag caatgcccgg acttgtgtgg 5940 
           ccacattgtc tcccagtggt gagcccatgt gatgtttcac aaaaatgcgc aatcaaaaga 6000 
           ggaaactggc cagcaaagat gaaagagtag caaacaaagg aagtgaaaca ttctggaagt 6060 
           aaaatttgaa tcaaacataa gttgatgtat acaggaagta gccaccctga ggatgttgtc 6120 
           actgctgcaa ttcaggagac tctaaatatg cagtcagagg aacgtagtga ggtgaaggta 6180 
           tccgtataat ggggaaagag gttgtgataa agagtgaagg tgtcccagag gaagcgatgc 6240 
           tgaaaaatac accttatgtt aaatacactg tcagtatatc atgacattaa agtgcaaatg 6300 
           ataacatttt gtaaactgat ccaaacttaa aaaggagtat gataattctg taaaacataa 6360 
           aaatcatgcc gattccataa attatacagt gtgaattaca ctgaaaaatc caacattaga 6420 
           gaggatatga atacaatttt ttacaagcat aattttaata atacacataa taattatttg 6480 
           tattcaagtt tagtaatggt caaggtttgg aagaaattct gatcctgtgtagagacccta 6540 
           gtttgaatgt gcttatagcc tattattaca tgtgtaatgt tacataaatt acttaactca 6600 
           gatttttaat ttcatcagct atttaaaatg ggcataatat aactatatta agtggatgtt 6660 
           atgaagatta aataagatga tatgtaaaat gtgttttttg tttgtttgtt tgtttgtctg 6720 
           tttgtttttt tgagacagag tcttgctctg ttacccaggc tggagtgcag tggcacaatc 6780 
           tcggctcact gcaagttctg cctcccgagt tcatgccatt ctcctgcctc agcccctccc 6840 
           aagtagctgg gactacaggc acccgccacc acgcctggct aattttttgt atttttggta 6900 
           gagatggggt ttcaccatat tagccaggat ggtctcgatc tcctgacctc gtgatctgcc 6960 
           cacctcggcc tcccaaattg ctgggattac aggcatgagc cactgcgccc agcctaaaat 7020 
           tttttttaca taatgggtgt tcagcacatg ttaaagcctt ctctccatcc ttcttccctt 7080 
           ttgtttcatg ggttgactga tctgtctcta gtgctgtact tttaaagctt ctacagctct 7140 
           gaattcaaaa ttatcttctc actgggcccc ggtgttatct cattcttttt tctcctctgt 7200 
           aagttgacat gtgatgtggg aacaaagggg ataaagtcat tattttgtgc taaaatcgta 7260 
           attggagagg acctcctgtt agctgggctt tcttctattt attgtggtgg ttactggagt 7320 
           tccttcttct agttttagga tatatatata tattttttttttttctttcc ctgaagatat 7380 
           aataatatat atacttctga agattgagat ttttaaatta gttgtattga aaactagcta 7440 
           atcagcaatt taaggctagc ttgagactta tgtcttgaat ttgtttttgt aggctccaaa 7500 
           accaaggagg gagtggtgca tggtgtggca acaggtaagc tccattgtgc ttatatccaa 7560 
           agatgatatt taaagtatct agtgattagt gtggcccagt attcaagatt cctatgaaat 7620 
           tgtaaaacaa tcactgagca ttctaagaac atatcagtct tattgaaact gaattcttta 7680 
           taaagtattt ttaaaaaggt aaatattgat tataaataaa aaatatactt gccaagaata 7740 
           atgagggctt tgaattgata agctatgttt aatttatagt aagtgggcat ttaaatattc 7800 
           tgaccaaaaa tgtattgaca aactgctgaa caaaaataaa atgtgaatat tgccataatt 7860 
           ttaaaaaaag taaaatttct gttgattaca gtaaaatatt ttgaccttaa attatgttga 7920 
           ttacaatatt cctttgataa ttcagagtgc atttcaggaa acacccttgg acagtcagta 7980 
           aaatgtttat tgtattttc tttgtattgt tatggtatag ctatttgtac aaatattatt 8040 
           gtgcaattat tacatttctg attatattat tcatttggcc taaatttacc gagaatttga 8100 
           acaagtcaat taggtttaca atcaagaaat atcaaaaatg atgaaaagga tgataatcat 8160 
           catcagatgt tgaggaagat gaggatgaga gtgccagaaa tagagaaatc aaaggagaac 8220 
           caaaatttaa caaattaaaa gcccacagac ttgctgtaat taagttttct gttgtaagta 8280 
           ctccacgttt cctggcagat gtggtgaagc aaaagatata atcagaaata taatttatat 8340 
           aatcggaaag cattaaacac aatagtgcct atacaaataa aatgttccta tcactgactt 8400 
           ctaaaatgga aatgaggaca atgatatggg aatcttaata cagtgttgtg gataggacta 8460 
           aaaacacagg agtcagatct tcttggttca acttcctgct tactccttac cagctgtgtg 8520 
           ttttttgcaa ggttcttcac ctctatgtga tttagcttcc tcatctataa aataattcag 8580 
           tgaattaatg tacacaaaac atctggaaaa caaaagcaaa caatatgtat tttataagtg 8640 
           ttacttatag ttttatagtg aactttcttg tgcaacattt ttacaactag tggagaaaaa 8700 
           tatttcttta aatgaatact tttgatttaa aaatcagagt gtaaaaataa aacagactcc 8760 
           tttgaaacta gttctgttag aagttaattg tgcaccttta atgggctctg ttgcaatcca 8820 
           acagagaagt agttaagtaa gtggactatg atgccttcta gggacctcct ataaatatga 8880 
           tattgtgaag catgattata ataagaacta gataacagac aggtggagac tccactatct 8940 
           gaagacggtc aacctagatg aatggtgttc catttagtag ttgaggaaga acccatgagg 9000 
           tttagaaagc agacaagcat gtggcaagtt ctggagtcag tggtaaaaat taaagaaccc 9060 
           aactattact gtcacctgat gatctaatgg agactgtgga gatgggctgc atttttttag 9120 
           tcttttccag aatgccaaaa tgtaaacaca tatctgtgtg tgtgtgtgtg tgtgtgtgtg 9180 
           tgtgcgtgtg tgtgagagag agagagagac tgaagtttgt acaattagac attttataaa 9240 
           atgttttctg aaggacagtg gctcacaatc ttaagtttct aacattgtac aatgttggga 9300 
           gactttgtat actttatttt ctctttagcg tattaaggaa tctgagatgt cctacagtaa 9360 
           agaaatttgc attacatagt taaaatcagg gttattcaaa ctttttgatt attgaaaact 9420 
           ttcttcatta gttactaggg ttgaatgaaa ctagtgttcc acagaaaact atgggaaatg 9480 
           ttgctaggca gtaaggacat ggtgatttca gcatgtgcaa tattacagc gattgcaccc 9540 
           atggaccacc ctggcagtag tgaaataacc aaaaatgctg tcataactag tatggctatg 9600 
           agaaacacat tgggataaat cggctgctat cataatcatt cctctcccac atcagataaa 9660 
           tgaattaact ttttgaatag ggttatttaa tataaagtgc ttaagtctaa ttatgagaag 9720 
           aaataagata attacacttc aatggttaaa gagagggaga ataatttgca tattatgcct 9780 
           gatgtaaaat gtttattatg ggtacatatt aagtgctaac taattgttaa ttgttcttgc 9840 
           tacaagtctt aatgcaggga aacaagaaat tattacatag tacctaatat tatcttctaa 9900 
           tattaaagaa acaatttccc ctaaattcat cccattagct tttttttttt cggtggggca 9960 
           ggggagaaat acagacttca gtaaacttgg gctgggaact ttctacctac aaagttcaaa 10020 
           taaaataaat tatcctagtt agataatatc aatgaaaaat ccaccaactt aaatcctggc 10080 
           tgtttgatct caggaaatta tttcagttat caacttaatg catcatatta tagaaatata 10140 
           tgaaaatgtg tttaattaaa ccttactgaat gatatgtttt ttcaggtact ttaaaaataa 10200 
           actatgatat aaagttacct atttttcatg caagtatagt ataaagaaat ttctaacact 10260 
           ggagattttc tgaaggtttt gattcttata aatttattac atcataatga acaaaactaa 10320 
           ttttcaacat attatgattt aaatttcctt agtaaattgt ttcaaattta ttttctttaa 10380 
           atccatattt acatatgtat atttaaatat acatatttac ttgtataaca attcaaaacc 10440 
           atatattaat tttataattt tgtttaatgt caaaggttag atttggctat atctattcta 10500 
           aaagttggta tcacatttcc tttttggaat tttatttta aagtagctaa agtcaaatat 10560 
           aaacctatta tttatattaa tgcagacatt agaggtagac actaaattca ttttagtata 10620 
           ttctaaatta tttattatct actatgaaat aatataaaga aaaataaagc agaatccctg 10680 
           atttcaaaga actcaattgc cgaaaaacag ttaccatta ttagacccaa aatgtactaa 10740 
           tatgagtgtg tctcttttcc ttttgttttg tcacccgtca tttggaatgt cagtgagtag 10800 
           agagatagtg tgaaaggccc tcaaggggaa aaatagaggt taaaggtcag cagagaccct 10860 
           actagagaaa tcagttctac agaaatgttt ttaaatgtgt cgattattgc tacatgtaca 10920 
           ctctgtcatt ttgtaatgta gccattttat ttatgattat aataataaaa caacaaaatt 10980 
           ataataatgt gtagagtaca ttttactgtg cagtgtattg cattaaaact agattaaaat 11040 
           ttatacatat ataaaaggct atctagatat tataaaattt atggctggat ctgtaaaaaa 11100 
           ttcaaaacct atttttaatc tcgctttgag attttataac aagaaaatgt tcgtttcaag 11160 
           caaaattttc aattcacgtc cttgaaaagg aaaaaaatga caacttgaaa cacataattg 11220 
           actattttta aaggatcaac atttcagaaa tgttttaaaa cataagattt tcagtacagc 11280 
           ttttcgctgg catttaaatc gaactttgaa ttgtaaatag ctcttgctct taaggagaca 11340 
           tcagccatat ccttagaagt ggcacggagt tgttaggtag ttgtacaaaa ttctagccta 11400 
           aaagacaaat agggagcaac actactgtgg accgtttctg gtcttgggct gtgtggctat 11460 
           gtcaggcttg cccacattgc ctgtactaag gagaaagcct cttgtcctta cagaccccct 11520 
           tagcttacat agtctatttg aaaacaaatt gctttgtcca caccattaa atattggctt 11580 
           caggccaggc gcggtggctc acgcctgtta tcccagcact ttgggaggct gaggcgggca 11640 
           gatcacgagg tcaggagatc gagaccatcc tggctaacac ggtgaaaccc tgtctctact 11700 
           aaaaatataa aaaaattagc cgggtgtggt ggcgcgcacc tgtagtccca gctgctgggg 11760 
           aggctgaggc aggagaatgg cctgaacccg ggagtcggag tttgcagtga gccgacatcg 11820 
           tgccactgca ctccagcctg ggtgacagag caagactccg tctcaaaata aataaataaa 11880 
           taaataaata agtaaatatt ggcttcttca actggtgaga tgaaacctat acaatagtca 11940 
           tgtgaatagc actaaacagc tgacatggtg taactcctct cagactgagg cttatctggg 12000 
           gagtacaaag catgtcaaga aaatgtgcct tcatttcctt agatgagtgt ccccatcctc 12060 
           cactctcctc cactgttctc ctctctgctt ctatgatatc aacttttctt tttctttaga 12120 
           ttccacatga gtgagatcat gtggttgttt gcctttctgt ttctggctta tttaactgaa 12180 
           caagaaagtt tttgacatga aattaaactt ctgcttgtaa actcaattca aactatttac 12240 
           actgtcttct caaaaatgtt aacttatttt aataaatcta ctgaatgacc gtatctcatt 12300 
           ttgttttatg aaaagaaatt gtaagggtgc tcaatagcct cttcattttc atactgtcta 12360 
           gctcctgtgc tcctattaaa attackgcaa atttagcttt ttaagaaccc tttgtttcac 12420 
           tacctgaagt tctataaaaa gatccaagtt ccttcacaac cgtttcttat gctgttattc 12480 
           gtacatatgt gataatacca cgtctgaaca cgtagataat aagtaggggc tgggtgcggt 12540 
           ggatcatgcc tataatccta gcactttggg aggctaaggc gggtggatca cctgaggtta 12600 
           ggagttcgag accggcctgg ccaacatgat gaaaccctgt ttctactaaa aatacaaata 12660 
           ataataataa taataattag ccaggtgtgg ttgtgggcac ctgtaatccc agctactcgg 12720 
           gagactgagg caggagaata gcttgaactc aggaggcgga ggttgctgtg agctgagatt 12780 
           gtgccattgc attccagcct gaacaacaag aatgaaactc catctcaaat aaataaataa 12840 
           atagaagtat gtattgtgtt gcttagaagg tgtggtggaa attaacttgc tgagtgagat 12900 
           caaaggattg gcactgaatt gaaataaaga aatattcatg ctgagtctgg ttcaaatata 12960 
           actgcacctg taagaattgc tttctgtaaa ctttccatag tataaaccaa atccaaatca 13020 
           ctcatggctt tacattcctg atcgttaaac ttgaagcact ttttaatact gcatgacttt 13080 
           agccaaaata tcttagccaa gattcaatgt ttggttgaac cacactcact tggacatctt 13140 
           ggtggctttt gtttcttctg accactcagt tatctatggc atgtgtagat acaggtgtat 13200 
           ggaagccgat ggctagtgga agtggaatga ttttaagtca ctgttattct accaccccttt 13260 
           aatctgttgt tgctctttat ttgtaccagt ggctgagaag accaaagagc aagtgacaaa 13320 
           tgttggagga gcagtggtga cgggtgtgac agcagtagcc cagaagacag tggagggagc 13380 
           agggagcatt gcagcagcca ctggctttgt caaaaaggac cagttgggca aggtatggct 13440 
           gtgtacgttt tgtgttacat ttataagctg gtgagattac ggttcatttt catgtgaggc 13500 
           ctggaggcag gagcaagata cttactgtgg ggaacggcta cctgaccctc cccttgtgaa 13560 
           aaagtgctac ctttatattg gtcttgcttg tttcaggcat taacccagat aaatgccatg 13620 
           caaattttat aattattatg attgtttcaa tttctggaag aaagttaatg aaacaaaaaa 13680 
           tgtagtaaaa tgccaaagga acagtgacat ttcagaaaga atgagggctt tcatgttaat 13740 
           tgtaagtctt ggaatttctc ttccttggag taacaaatcc ctttgtgcct aatttcctaa 13800 
           tttccaaaat aaagttcttt tacttatttc tttatagtga catcatctct tattaaatgg 13860 
           catatctgca tattacataa cagttcattg ccaaatacat atttgtggga aatgagagac 13920 
           ttaaaataca taccaaccag agatatagtt ttgaggtaga ttttaaaatt ctgagaagaa 13980 
           ttttgactga atttttttga caaacatggg acacgaataa gattatacca aagatattat 14040 
           aactttcatt ttaaatatgg aactaataca gtatgaggtg tcaacaacgt tgaagtttca 14100 
           caaacatcac cactacaaca gcaaaataat ttttgctttt tccctgccac aatgacctcc 14160 
           ttgctatttc ttgaataaat caagcatacc cttgccctga cacgttcttg gggaggcctg 14220 
           ccctaatcta tataaaattg gagccattct tctcacctct ggtattccca gtctccctac 14280 
           tttttttcct tctttctttc tttttctttt tctttctttc tttccttctt tctctctttc 14340 
           ctttctttct tttcccttcc ttccttcctt tctcccttcc ttccttcctc cctctctccc 14400 
           tcccttcctt cctccctttc tttctttctc ttttttcttt cttgcttcct tccttccttc 14460 
           tttccttttc tttctttttc ctttctttgc caaagtgtta ttcaccttta aatataatac 14520 
           ataatgtgct tactttaatg tatgattttt attttatttc tcccttctag aatgtaggca 14580 
           ccatgagagt gaaatatatt tattttgttc attgatattt cacaagtgtc tgggagagtt 14640 
           tccaacttac agtagacaat taacaaacat ttattaaatt aaggagggaa ggaagtgagt 14700 
           aagcacaaca actttcattt ctgggtcttt tataatcata tgcttagtat aagaacagtg 14760 
           ctattcagct atccaaaagt tacaatcaaa atgattttgg atgaatatct tgaaaattgt 14820 
           gagaaagaag ttttatttgc tggcaaacta ttctgggttg tttccacttc atgtaatcct 14880 
           aagtagcagc cttaccttga tagcccatta aaactctgat aataaaaagg cagaacaaaa 14940 
           atatctgtga tatatttaga tttactacat gtacttacat gtctagtgtc tggtgcaatg 15000 
           gatgctaatg atggcaaatc cttactgggc ttctagtgaa gttcttcagc taatgtttga 15060 
           atgcatggtt ggtcatggtg gtaccccttt gtacaaaata tgcttttcaa ataatcttat 15120 
           tagggataat aattatatta attcctggtt tccatctaaa attttaattc tattatagc 15180 
           ttcgtaagat ttcacaagtt aagagggacc tcagattaaa ttagtacaca ggcaattaat 15240 
           cagttttgtg tctccgaccc ttttcacggg ctaatagaag ctatagaccc tcttagcttc 15300 
           agaaaaatgc gcactcacat acgcacatca aagagcttaa tgggaagtcc attgacagac 15360 
           cctctgttca gatcaatctt ctgattgtag agatgaggaa acagaaatct acagaggaag 15420 
           tgggtagtcc aagattgcac agtcatttgg aatagactgg acaccagtag tacttttcca 15480 
           gccactatat cacttcccca agcacttcct caaaacttac cttcctttgg gtctttatac 15540 
           attcagttat ggacaactag atttaactag aggattttat tgcttcagaa tattaagcaa 15600 
           cagggaaaca tgtaccgtct tttattcacc tgcatttaag gcatacaata taaattgcaa 15660 
           atggagcatg aaagtgctta atcttttaca aaactgggtt tgctttccac ccatctaaaa 15720 
           atacttctat ttattttaat atttaaagca gaaatctaag tgatgtgaca aaattaatca 15780 
           tttggagata tttcccttat aggtagtata gtttcttact gatttctaat atgaaaatga 15840 
           agccatagaa cctagaaatt gcagcatagt tgtggaaata aacattggac tgagagtgaa 15900 
           aatggctagt cttcctctct gctcatacac cacctgactg gataaccttt cgcagatctc 15960 
           ctaaaagtct ttctcataaa atgaggaagc tctactagaa aattgttgaa gtctaattta 16020 
           gcaataaagt tctgagtttc tataataatt caaagaatac tctaataaat gtctgcaatt 16080 
           gtggtcacat ctatgggatg ctaaaaaatc tggatggttt caatgaaagt atttaatttg 16140 
           ttcattatga actttgaaat aatttatttc attttttaaa ctttgatcaa aatgaccctg 16200 
           gtaaatagaa ataagcaaac tctttttgct tgaaatgctt attaatgact gcattgagac 16260 
           actcattcat cattcaagaa agaatgtttg ctcacactgt gccagaaact tggaggaaga 16320 
           gggatgtgac aagtagggggt actggatgtc tagcttgtag aagtggatta atggctctgc 16380 
           ttttaagatc aggaacactg aaagggagta atggcaccgg ttttcacctt tcatgccctt 16440 
           tgagggtatc tggtccatca ccctctagtt gatgaggggag ggaaagttcc ctctcccttc 16500 
           acaaataggt ggaaattaaa tgacataatt ctgaacaacc aataaatcga gagtaaatca 16560 
           aagcagatac ctgttttgtt aatttgatca tatgaatgta gctgccctta gtaataattt 16620 
           ctaagtataa gactagttaa aggacaaatg agttatcttg aattataaga ttttgtttta 16680 
           cagaacaata ttaactcttg tgtttagtac attagaataa tagatctttt gatccatatt 16740 
           tttactcatg tgcacataag aagttatcag tcatacaatt catttcttga agttcatacc 16800 
           tttcattggc agagtagaaa caggttaaaa gtgcacaggc agaaatttta agtgcaaagc 16860 
           aacagtgatg ttatatagag aaaatttata tttccctactt ctattgaaga agaaagatct 16920 
           gcttgttcta agaatattgt acaaagaaag tgacttgaat cagcgttatt ctgtaatgct 16980 
           actatgcgtg cagtgtggag tagccactag aacacttggt ctatcccagc tcctcaacag 17040 
           tgtcttgctt gtggctggtg ctcaaataaa tccttgctga actaatgagc atctctttca 17100 
           tgccacatgg aatgctctaa aagagttgga tcctgaagtt tttatatttt tgtaattttc 17160 
           tggagtttta gagagcaaaa gtcctgaata aactgtgaag ccactgcctg acaaataata 17220 
           cagcagtcag cttcgttatc atatcccatt gagacacgac ttatctacat gatgattaat 17280 
           agttttcacg caagaaataa gcttgaaatg tctgttgcct tggatactta aaacatccag 17340 
           gttcagcgat gttatttatt gttgttcaaa atcagaatga agttcctaag caatgccatt 17400 
           ttggaaaaat tacatcaata tattatgaac aacttttttt aaatcttgat ttcaaatgga 17460 
           ttgacacgtg tatattctgt aataatcctg acttaattca taaaaggata gctagccagt 17520 
           tgtgtgctag atgaataaaa aaaaagcagg ttttaaaatg tcaggtttga cattgtgaat 17580 
           ataatatcta agtatccttt tactcatttc ctttgactta ctatggctgt catgttgggc 17640 
           ttcatgaaaa tttattttta aacacttgag tgttatggac cctctgatta aatgattaat 17700 
           cagatgatgt atgttgccat cagctgaatc atttaatgtt gatttcacaa acaagcacag 17760 
           gtcacaggca aatttcaga tttctttgaa gaagcacaca caggtcacag gcataatctt 17820 
           aaaataattt tataacaagg tagtaataag agatgtcagg actggagaaa tatttaatt 17880 
           tatagtaagc tttcccctta agtgtctaat aattgttaat ataatacatt gcctcaaata 17940 
           attaaaagtt tggttcttgt ccttgtgctt gacttcagaa gataaccaga tgactattag 18000 
           gtatatttag acctaaatta aaagctttga gacacaatga attgcctgat ttgtatttgt 18060 
           gtttcgagtg gcatatacta ttactggcac tataatctta gattaaagca tactgtgatt 18120 
           attaaagaaa aatttaagat tgatttgttt ctaaaggtat gtaacagtga cattttgcaa 18180 
           tgtggtatgt aaaagttggt atttctcact catatgagag cccactaatg gtacataaac 18240 
           tgtccccact tagaaacaca attattatgg cctttctttg tatctgacaa aatttcactg 18300 
           ggttcaagat ggatgaatag tgaattctaa tgacccttaa tcctgtaagg ttctaggtgg 18360 
           gaaagtactc tgtaattatg tataaaatta taaggaaaat aggcttactg ctatgttttc 18420 
           attaaaaatc attaactgag tacttaatat gtgccagaca ctcagctggg caccatgaga 18480 
           aatacaaaac tgagtaacat atgggtggct cctgccttca agaaatgggc agttcaggcc 18540 
           gggagactga catatttacc ctgggaaaaa gggagcagct gtggtctctg agaacaatat 18600 
           ggtttgttac aagtatatat ccatcatgga aaaaaagaga tttatcttag aaatgagaga 18660 
           ggctgatgct ctcaataaat atcatacatt aaattgtgtt tttgtcagta gactgaaatt 18720 
           acctcacata cacgcacaga tagtagccat gatattttag ctgcttagat atagagacaa 18780 
           atacttccac ccaaatctta ggatcagtgg ttaatagtct gtaagcatta caatcccaca 18840 
           acatatgcat gactatacat ccaattttaa tattcaaaga actgattgcg atgatagttt 18900 
           tgtttgtcaa agaaatgtat tataggatga gtgggataga actgcatcac gttacaccaa 18960 
           caaataggtt taaatcatat ttgtgcactt cccttgttcc ttcataaatg tttaacatag 19020 
           cttaaaattc tgtggactgc aacgtgagag caatgaccac acttctgtga acccartttt 19080 
           actgtgcatg tgctaacgtc tattgttagt attccttcac ttgcaaagat ggcatgataa 19140 
           ttttgctggt ttcattaatg agatactgtt aaatgtagga tgacttcaaa cttagttgta 19200 
           ttgtaaaatt atttttaatt gtatacattt aagttgtaca gcatgatgtt ttgagatact 19260 
           tatctttatt tatatatata tataatatac acacgtatat aaaagtgatt cctacattga 19320 
           agcaaattaa catacccatc atcatatggt tatctttgct tttttactat cagtgcctaa 19380 
           aatctacttt cttgaaaaat taccagtatg cactacaata ttattaacaa taatcttcat 19440 
           gttgtacatt agatctttag acttactcat cttacatgac ttaggtttgt ttttacctct 19500 
           actaccatct gagccatatt tccactttgt aatttgataa taaacttgga aaaatagcac 19560 
           ttatatgttt aggtgacggg cataaatagg ataagatgtg tttatatatt attccatata 19620 
           tcttgtctcc aactacaatg ataaacaacc tgtttgtccc taaaaagtaa gaaataactt 19680 
           gacttttctg ccccttcaag cataggctgt tagcttttaa gttttaggga gacattgatg 19740 
           atgctatttg ctttatcaag aggaaattgt caaaagaggt cttttggttc tcaaactatt 19800 
           caaagtattt aaaaatcagg acaaaatatg tttacgtgat attcaagggt acagaaatga 19860 
           ggtaaatgag atgccaattg tatttgtcat gcaaatatat aattacgtgt atgagagtta 19920 
           gatgatacat ctcatcaatt taattgttct tctacaagga gaaaatgaac aatttgtcaa 19980 
           ctcgtatatg aagtaatttt tataagaaat tttattaaaa cttttaacaa catttggatt 20040 
           tttaagttgc aatttaaata tccccttcta ccaggtgatt ctggaatcac taagcagtta 20100 
           cttgtgaaaa ttccaaagta gcatttaatt cttattaatg tcatagtgaa tactaatgca 20160 
           aagaatactg agccagaaat tatgcttgtt gaataaatag attatttatt gaacaagtaa 20220 
           gtgaaaaaat ggaaataaag aacggatata tattttatct tcctgcttag atgtgggact 20280 
           gtcctacttt tctctggtgt tcacaacaac aatatgataa atctaattgg aattcagttc 20340 
           attaggaatga attcagttac attatggatt gtgatgaata atgtacactt ttaatttaat 20400 
           gaaatcaaat agattttaac tatctatgct tacaatgggg tgacataagt ctgacaatcc 20460 
           ttaatatcaa gtcatctcca attcacatgt atacacactt tttttctatt tggctattgg 20520 
           gaatcctcac aaaaatcgaa aattgccctt tcagtgtacg ttacggtatt tcatgccaca 20580 
           cagattttct gaggttgtac atacagcttt gccttgaggt tccaattttt gctcagtgga 20640 
           ttgagtatat attatttgct atatatcaga agaggcatgt gcttcctact tatgtcaggt 20700 
           aactttggga ttaatataat tgtcctacaa agcatagata gatagaaata cttcatcctt 20760 
           aatttctaat attatgacat atctaaagta ggcaccttta aaagttaatc tccactaaat 20820 
           actaatgact gcttatagtg gcaattcatc tttcatggta gtcctcctac aaaggtatac 20880 
           taacatttat gagtttgaaa caaaggcaat tcacaagtgt tctgctagag atggtctata 20940 
           tctgctgttt gatccagcat gatggccagc tggccctcct gtgcatgacg gctcgtggtt 21000 
           taactgcacc attttgtttg gtcatataca gggaaaacat ggcatggtgt ggagggcatg 21060 
           ggcttgaatt cagggaacag agagttggtc ttctctctct cactctactg gatgatgtca 21120 
           tctcccctct ctaagcatga gttttcttat ctgtgaaata aaaatgttga attaaatgag 21180 
           ttcaaaatgc tttcagtctg tgtttaatag cttgaatctt aagacaatgt attcaattat 21240 
           gcgttgccag atccctggca actcatgtaa cctttctaaa ccatagctac tcatctgtaa 21300 
           ctggccagcc aactgcccag ggttggagtg tgaatgaaat aagataatgc agacaaaaga 21360 
           tttttaaaaa ttgtagtgca ttatacagtt gtaatatttt gccaagaact tacattttct 21420 
           ctaagaagtg tgtcgataca tgatcacaga aaatcttttc catattcctt tgtagtttga 21480 
           tgatattaag taagtaaatt gtataacaca aagagggaaa agcatcactg aacatgccgt 21540 
           tttatttagc taaataaaat gtaatcacta ttagttttcc tctgatttcc ccaaagtcat 21600 
           gtgattccat tgagtattat gcacatggta taattagaat ggattctctg ctcaaataat 21660 
           tttgggaaac atttaaatta acaaagttta aaagtatctc tgttaagctg aagcaaatct 21720 
           caaaggcctt aatattgtat gtaagaggaa tagttaccat ctttcctaat gcctctttga 21780 
           cgccaaaccc atggagaata gttctaggtg ttcagtaaaa cacagatttg ggatgccaca 21840 
           ggttaattgg aactgtcccc tgcaatcctt ttctcttttt cttaataatg gctgattgca 21900 
           ggtcctagat gaaagacatt tagagagatt atcaggactc agcatcccat atcagaatcc 21960 
           attcttttat agtcattttc tgttacattt cttgggacaa caccaaagaa atgaccatct 22020 
           tcattcacat aggctttgta ccaaatgctg acaaagatcc ttggtgacct agatgggggc 22080 
           aggtctaagt agattgcagc tgtaaaattg gctgatgaat gatctcagcc ccttttactc 22140 
           acactcaaag gcaggacagt ccattaaggg gaaggagggc agagtttttc cttaggccaa 22200 
           ttccctatgc cagaactttt tagaatggaa gcatttccag aggagaaaca accccaagca 22260 
           cagttcaaag ccccctcctc ccaagttcat ttgaaagtgg gatggtttat ctgcaaaggg 22320 
           ggaaaagatg agggataggg acgggaatat ccctaccctt cagagagtct ggtttcatcc 22380 
           tgcactttta ctgcacagcc acaaatgcct tggggtgaat ctacaatatg atacatcata 22440 
           tggtctaaac gtgcctggct gatcctctct aatacttcag gggtctaaaa gggataacat 22500 
           gctctcctgt tactcaccga ctctgtccgc catatttcac ccagccagcc actgccttca 22560 
           cttccgtccg aggcctaatc tgagcccatg ggaaacctaa gaacccctac cacaactgcc 22620 
           tcaactcttg ggaatcaggg tgtatggggg tgacaggaag tgagcataca ttctccaact 22680 
           tgatatgtca gcccccacgt ctgtatgaat gtttgctcac actgtgactg ccggccttgc 22740 
           tcctcaggct gcatcctacc agggagtaag acccaagtcc ttcctgcttt cagacaacac 22800 
           caagcctcat gagtccccac tcagaggaag gaccagagac aaactctaat gttccactaa 22860 
           tacttccctt cttattactt tccttgaaaa tcccttctcc ctctttcttt ttatacttcg 22920 
           ctaatgaaag gtaatgaaag ggtctggcac ttggaattta gaattgatac atggttttta 22980 
           acccgcggac gtattccaca ataacccttg catcttctac taagatgtgg gctaggaagg 23040 
           gaccagccag ttcccagggt cacagtgcct cagctgatgt ttcatatttt cagcaacttt 23100 
           atgttagaga tgtccatcaa tcagaacaat atggttagag aataaactaa taaaagtcat 23160 
           ttttgaggac atgttggaag tctatcaaaa gcattgaaat tatgcatgct ctgaccagtc 23220 
           gcatgtctaa gaatttaaat atgatcataa gtttaaatat gaagatgttt atcacagaat 23280 
           tgattataaa acaaaattga aaaaaatagt gctagaagtt tgatcatagg gacctcatta 23340 
           aatgcatttat ggttgatcca tgcagtggtt tgctgaacag ccattaaaat gttgtagaat 23400 
           aattattaat ggtgtggaag gatgctattg ttgcagtatg tgaaaagaac aaattacaaa 23460 
           gcagtttgtg cagcataata tttttatttt ttaaaaacct gtatgtggct tatgtacata 23520 
           taaagacgtg gaataaatgc acaaggtact cagtttttct cagtgaagcc cattttgcat 23580 
           tttgggctgg gtaattcttc gctgtggaga actctcattc attgtaggat gtttacaagc 23640 
           cctgggcctt acctctttaa cgccagtagg cacccccagc atggcaacaa gcacaaaatg 23700 
           gtctctctca tattgccctt gaggaaattt tgcaactaag taactattac tgggtcctag 23760 
           attacagtct ggattattgc gttcctttct tatttttatt ttctccaatt ccctttaata 23820 
           agcatgtact ggattcataa aaaaacaaca taaatggtaa ttacaatatt ccgcactggt 23880 
           taaaacttat gtaaataagc attctgctgc tttagccaca attgcaattt atgctccttc 23940 
           tctttcttaa gttcccagtt cccacgtaca ttcattcgac tgattcaaaa gtcattttag 24000 
           cttgatagac tcttaaaagt tagagttatc atttctgcta tttattcttt caattatcca 24060 
           tttgtccacc catccatctg atccattttg ttgatgcatg ctgtgtataa aatactacac 24120 
           cagcctggtg cggtggctca cgcctgtaat tccaggactt tgggaggcca aggcgggtgg 24180 
           atcacctgaa gtcaggtgtt tgagaccagc ctggccaacg tggaaaaacc ctgtctctac 24240 
           taaaaataca aaaattagcc aggcatggtg gcagacgact ctaatcccag ctacttagga 24300 
           ggctgaacca ggagaatcgc tcgaacccag gagatggagt ttgcagtgag ctgagatcat 24360 
           gccaatacac tccagcctgg gtgacagagc aagactccgt ctcaaaaaca aacaaaaaaa 24420 
           atacaatgcc aagcatcata aaaaatatag tgatatataa gacctatttg ttgtgctcta 24480 
           ggcattgaca tctagctgtc aaccattaat atgtgtagga gtctatctat caatattatg 24540 
           gactgtgctt gaagacttct tccccaatct ttttctcttc ccattaagtt tgaagtgagg 24600 
           ttttctgagt gaagtatcat agtacataca gtctcattat ttttcaaaaa tctctggtta 24660 
           tagtacattt ctttccttta tcccctttgt tcccaactat caaaccattt tggatatcca 24720 
           gtattggtat ccagtattat taaaaagcaa aacagagaac tattaacaaa aaaatttgta 24780 
           ggagtaattg gttgtatggt atccagtact attagtagt aaatcagaaa atttattaaca 24840 
           aaaattttag acgaataatg gattgtcttg cccaagtgaa ttgagtgatt tagttgttct 24900 
           ttcattttta gcaagtacag ctgatcattt gaggccttac tcattgtttg attttgcaaa 24960 
           ttcttactat tataaatgtt ttgggctctg agaaagctgt tgtcttaatc tgtttgtgct 25020 
           gttataacaa aatacatgag actgggtaat ttacaaacaa cagaaattta tttctcatag 25080 
           ctctggaggc tgggaactcc aagatcaagg catttgtctt caggttcagt atctggcgag 25140 
           ggccggttct ctactcccaa gatggtgtct tgtcactgta tcctccagag ggccaaatgc 25200 
           tgtgttctca catggtagag agatagaaag ggccaactca ctccctcaag gcctttcata 25260 
           atgttaccaa ttccacttgt cagggctctg cccccgtgac tttattacct ctgcaaggcc 25320 
           ccaccactta atactatcac gttggttat acgattattc acatgaattt cgaccatact 25380 
           agttgccatc ctttcatttt catatatcct taaaactttg cctttctcat tttaatgtac 25440 
           tttatccaca gtatgccaac ttttcgatac ttttgttaac ctgtctgacg atatatagga 25500 
           aactgtaaaa gtgcagtttt tgatacactc tttagctgcc cgtttacttc tactgtcgtt 25560 
           agagaacccc atccatagtg catgtgttta ttttgtgtat gaacaaagac tttatatata 25620 
           gtttgggtca tttttattca ttagtgcttc ccttataatc tctgaatacc attttattag 25680 
           tacatactgc tattcttaat agtaactagc atgcctgatc atcccaaatg tctaggttca 25740 
           cattttaaaa taagttatat ctttgggctt aacagtttat tgaaaggtaa caaggattga 25800 
           gtcatagttg tatgtttttg gaagtagaat tcaactgtaa atagaaattg gttgtttaga 25860 
           tctcactata tatgaaaaaa tgaaggcttt aggagaaaat ctccccaaag tacccatttt 25920 
           tcatgtgata aatatcatga aatgatttga gaaaaaaatg tatatttgtt acagctaaca 25980 
           aatatttgtg ttttttattc ttcatggaga gaatgaaatt tcttctcttc tttacacatatt 26040 
           tctttttctt attagaaact aattggtgcc tttataaaaa ttaactgcag agcactaacg 26100 
           tgtatatata agtattatgt agggtgtagg gtatgttcag ggtatggtgt gtgtgtgtgtgt 26160 
           gtgtgtgtgtgtgtgtgtgtgt gtagctgtgtgtgtgtatataa tgaaatatat ggtaggtgttg 26220 
           tttcagaaat ctgcttggtc ttcccagagt tcattcatct tataaattca tctacattga 26280 
           tctctatttt tggaatccat gaaatgtttt ttggcagtac ttcctttaat atagtgtgct 26340 
           ggaaatctgg aaatttctag ccagattagt tacaaaaaat tagccagtgg ttttgcactc 26400 
           tctatagaat caaggcccaa ggcctactct tgttactcag ggccttgttt tatctggcct 26460 
           ctttcttttc agccatatag ctctcaaata ctcaacaaaa ttcttcattc taggtagaca 26520 
           agtatcttca aaatacttcc caattatcta ataactgtct taccactaag aaggctttta 26580 
           tgtctcctgt ctgaatttta tccatgcaaa aaagtccagc ccaagcctcc agaactccaa 26640 
           aaagttatcc ctaactgctg aaacacagta atttcactat gtgaaatttc actttggtct 26700 
           cctagcattt gcagatatac catacatatc cttgatcctt ttcctttcat accttttata 26760 
           tctaaccctt aagctaataa ttttacctac actgtaattc aaaatgtatc cccagtctta 26820 
           ccatgtctcc cttctctact gttaccacccc taggctaggc cttcatcatt tctcacctgg 26880 
           actccttccc taacctctga actgatctgc ctgcttccac ttagacaccc aacctagtcc 26940 
           attcttgagc agtcggaata attcttttaa gaaagaaacc agatcacatc cccctctgct 27000 
           cccaaccatc cagtgacctc ttatcataca tagaatgaaa tgcaaatctt tactgtgttt 27060 
           taaaggccct aattatctg gacctcagta acttcttact tcctatccct tttctccttg 27120 
           tatgccaccc tccaactaca ctctaactac actgtctttt tccctgttct tcagacctgc 27180 
           caaccatatt ttcactgctc aattaatatg tagaaaatga attgtttgtt aaatgtagac 27240 
           tgtttccttc ttaaagcaaa gataaatgac attgtcttca aaaacaacta actgcccaga 27300 
           attcctgatt ttaattttaa aaagacaaac tgcaagaatg tgttaaacag taaggaaaca 27360 
           attcactact tcagaattct atatgatttc actgcacgtt agtaattttg tatattatag 27420 
           aatatgaggg tattctaata aacttaactc tatgctgtat acttatcatg atagctcatt 27480 
           ttcttatatg tttataacag cactacttat tgtacatgga tacgtgggaa ataaattaat 27540 
           tttctcctta agaacaaagc aaccatttca ctcatgagat aaatcttgaa gatttaaaaa 27600 
           ctacttataa ttaattatac attattcata taatgttaag tattttctta gtaaaccaca 27660 
           taatttagaa tggcaattgg agatgggc agaaccacat gcatccacta ttaggcagtt 27720 
           ggtgagcata agatgccaga aagaagatta ggaatatcaa ggcagggagc ttccgatcgc 27780 
           tcttgaaaac attgaccctt cactcctcac tctccacgat gcatttcctt tgaaaagtaa 27840 
           tgccttccaa aacaaagttc tctgttttat atctaaactt actcaatagt ttctcatggt 27900 
           tattgatata taaaaaataa agtaaaatgt ttaggcagac caaaagaaga atttccccct 27960 
           ccctctgcct tttatgccaa ggtgacagct atgaaatgta cagtacgttt cctctgcaag 28020 
           gaatgtagca gtgttccatt gcaagaagat gagagggaga gaaaggttgc acgctgagga 28080 
           atatagtgtc atttgtcact gcctagactc atcagctgtg tggaactctg agaggcacca 28140 
           ggcttcttta tttatttctt cagaaacttc agcaaaaaag atttcattag gagcagagaa 28200 
           aaatgtgaaa aacgaattag cttttgtgat ggggagtagt catctctgaa tattgatcaa 28260 
           gattaagagg gttgtcttcg taacttcttt tatccatagt ctatactgat ttaactagaa 28320 
           aactaatttc aggtggtatt tcgggtgtgg cagatcttta tagtaaatga agaatctagt 28380 
           caaatctact gaaaaactct gcttacttta atgtttgatc tggttgaaac cattttagct 28440 
           taacaatcct tcctctgaaa cagggaatca attgatatcc tacagcaaaa ttatgtggaa 28500 
           gggccattag cttcacatcc aatgcaaatt ttgcctgtgt ttactcttcc ccaatccaaa 28560 
           atatatcaga tcctagatgc cagtgaaatc gtttgagcta gatggcttga gggtcatagc 28620 
           ttttttcatt tcctgttctc agacctctta taattgatag aataaaatca gaagagccct 28680 
           agagctgtcc cacctattct gcctcacaaa agtagaagta atggcaacca ctatcatagg 28740 
           gatcatgctc acctttttct taccagacaa atttggatat tagcttgaaa ttaatacctt 28800 
           ccttaaaatg ttggaatttg gttatatgcg aaattttgct ctatttattc attatatttt 28860 
           gtatggaatt atttttgccc tatattttca cttaagtgtt ctctacccaa gattttaatt 28920 
           gaacccaaat cagccagaca cacagacatg gattttgctg ccaccaaggt taattcttct 28980 
           tttaaagtta acttttaaaa tttggtaaaa tatagctttg aaaatttgca ttcgtctagt 29040 
           gtttgttatg tatttccccc ttttgtttga ttatatgtct atatttttct tgtagaaatt 29100 
           gatttttaac ctgcttttta tgttagcttt tatgagcttc tgtctgaatt ctgaatatgt 29160 
           ctttcttaat gtcttctaaa tgtttctttc tggattatta aaagatttat taggctttta 29220 
           ataattatat ttgttaccctt agggaatgtg tttgaaaata ttttaaatgg aattgccagt 29280 
           taacacagca ttgaactttt tcttgttaga gatacattgt tttctaggca ttttattggg 29340 
           agagaagtta gtatgatata atgtctttgg ctgatattaa ctcttctaag atgcattgtt 29400 
           tctgagaaca ccattgtctg atttcattca gggaaatttc acacaagcca gtagagtcaa 29460 
           tacttttttc aagacctgtt aattgatata tataaaaact tgccattgtt tacatgccca 29520 
           tttcagatcc tttatgtgac ctaagctaga aatgcatttt aacagcattt gtttttccaa 29580 
           aaatatttt ttatttattt attagaga tagcgtctct ctatgttgcc caggctggcc 29640 
           tcgaactcct gggctcaagc aattctcctg cctcggcctc ccaacagtgc tgggatacag 29700 
           gtgtgagcca ttgtgccagg cccttgtttttatttttttt gaacattgta ttttgaaagg 29760 
           ggtttgaagg tgatccctag atagcaacca gtaatgattc gagcagcaaa acaatctaaa 29820 
           aagtaatttt ataagaaaat gcagaacata aatgagccca taaaaaatta tattagggttc 29880 
           tattatcatatt actaccttct ttcacatgta atatttcact aacatttaat gaatttctgt 29940 
           gcagtgccat ataccattat gaattctagg atagaagaat gagtgagaaa tgttcttagg 30000 
           ccttaggaag aaggaacaag catctctgtg taatagttat ttcaactctt cttttacacc 30060 
           tcattcccat attaaatctc agaaaagcta aagtaatagc tatccccagat ctattttaga 30120 
           ctccagacac ttacttcaat gtcttgttct ccttatcaga ctggaatcat tccaaacctc 30180 
           ttaacttctg ggcaaccatg ataatgcgac agaaaggaca ctaaatctgt cgcaaattta 30240 
           tcttgatatt ctatccagtc ttacttggta ctgaaggtca caagtaaaat aaggtggttg 30300 
           ttttttgttt gtttttttttttttgacaga agagaaaaga acactgtgag cacagagtga 30360 
           atgtctaaca ttgattcttg agtagcagga attctctatg cgagaggatc tctatgcaaa 30420 
           aagatctcat attctagcac aatttaagga tctctatgca aagatatccc atattttagc 30480 
           attatcaata agctatgggg taatatattg tatgtggtgt ggcttgaatt ctagaaattt 30540 
           gatttctaga aatggtccct gtagttaagg atatataatg tggccgtctc cagttttcta 30600 
           tgaggaatag gaaaatacta tcatttattag ctgtgtgacc atggacaact tgcttcgttc 30660 
           ttcagttgca tcatctgtat aaaataagaa taagaaaatt tacatctgca aggtgtgatg 30720 
           gagatcacat gggataattg tggtcccaga gcctggcaca aaagggctta atatttataa 30780 
           tcctccccat ttctccgtat actctaaagg aagtttattg cttatcaaat tgtgccgtgg 30840 
           ttagttgtac agcttccctg ccaaattgta aactccaaca ctaatgtgac gttacatttt 30900 
           atatagtgct atgattttca aattgtttgc ataatttcaa atacacagta aattgctttt 30960 
           tattattata attattgcta ttgtcaatat tattattaca aagcttcac agtaagatgg 31020 
           gcagaaaaaa atttaatttc cattttacaa atgcactttt gaggctcaca gaagtcaaat 31080 
           agaccaaagt cacagggcta gtgagggacc cagaagaaac aaattgtaat tcactgattc 31140 
           caagttcagt ggttgcctta ctgcatcata aaggctatta cacaatccag gtgtatcata 31200 
           tgattcttgt ctatatattc atacatatca gaaaaagtgt tctactcaaa attgctagca 31260 
           atcaacagat actgatagtc attagtactt aaatctttat caaatgaaat attaataccc 31320 
           atgaaagaga ggacaatgaa aggtttgtat catttgtatg tcacaagtca acttttttca 31380 
           atcactcatt attagtttaa ctgtaaaaaa ttattattacat ttagcgtgaa actttcctgt 31440 
           attctcaaca tatttccttc ggtagaaaag caaacctcca gttctctgtt ctttgcttgg 31500 
           atacttgcca gtttgtaact cagctatcaa acagtaaagc tcacaaaaca cttattaaaa 31560 
           tgactaaaat ccaaaacacc aagagcacag catgctggtg agatgtggag caacaagaac 31620 
           tttcattcat tcactaatgc tggcaataca aaatggtaca gtaactttgg aagataggtt 31680 
           gacaatttct tacgaagcta aactatactt aacatatata tttgtccatt ttcacagtgc 31740 
           taaaaagaag ttcccgagac tgggaaattt ataaaggaaa gaggtttatt taattgactc 31800 
           acagctcagc atggctgagg aggcctcaga aagcttataa tcatggtgga aggagaaggg 31860 
           gaagcaaggc acctacttca caaggtgaca ggaaggagaa tgaatgcagg aggaactacc 31920 
           aaacacataa aaccattagc tctcgtgaga actcactcgc tatcatgaga acagcatggg 31980 
           ggaaacagct ctcatgatct agttacctcc acctggtctc tcccttgaca tgtggggatt 32040 
           atggggatta taattcaaga tgagatttgg gtggggacac aaagcctaac catatcacca 32100 
           tatgatccaa aatcatgcta catgatattc acccaaagga aatgtaaact gtgtccacac 32160 
           caaaacctgc acatgcacgt ttatagcagc tttattcata attgccaaaa cttggaagca 32220 
           accaagatgt tcctcaatag gtgaatgaac aaaaagactg gcacatgtac tcaatggaat 32280 
           attattcagt gataaaaaga aatgagctat caagccacaa aaacacatgg agaaaactta 32340 
           ggtacgtaag ccagtttgaa aggttgcatt ctatatgatt ccaatatatg aattctgaa 32400 
           agagacaaaa ttctggagac agtaaaaaga tcagtgattg cctggggctc tgagaaagtg 32460 
           cagagggatg aatgggtgaa gcacatggca tgtttaggac agtgaaacta ttctctatga 32520 
           tactgtcatg gtggatacat gaccttatac ctttgttaaa actcagaatt ttacaataca 32580 
           gagtgaattc taatataaac tatggacttt agttgtaata aggtatcaat gttatttcat 32640 
           aagttttaat aatgtaccac actaatgcaa aattataata ataggggaat tgggggaagg 32700 
           gtaatggagt atatgggaat gcactgtaat ctcagtacaa ttatccaca aacctaaaac 32760 
           ttctttcaaa aatacaagct attggtcagg tgtgatggct tataccagta atctcagcac 32820 
           tttgggaagt caagaccctc agatcacttg aggccaggag ttcgagacca gcctggccaa 32880 
           catggtgaaa tcctgtctct actaaaaata caaaaaaaaaaaaagaaagaaagaaaagaa 32940 
           agaaagaaca gaagaaataa aagaaagaaa ggaaagaaag aaagaagaaa agaaagaaag 33000 
           agaaagagag aaagaaagaa ggaaagaaag aaacagaaag agagaaagaa agaaagaaaa 33060 
           agaaagaaag aaagaaagaa agaaaagaaa gacagatgcg gttgctcatg cttgtaatca 33120 
           caactactcg ggagactgag gcatgagaat cgcctgaact cagaaggtgg aggttgcagt 33180 
           agggtgagat tacgccactg cactccagcc tgggtgacag agcaaggctc tgtctcaaaa 33240 
           aaaaaaaaaa aaagctatta aaaatatgta aagctcagtc tagatacagt accagaatag 33300 
           taggaacttt atttcacctg tcctacaaat tatggttgtg tgccacttgg gtaaaactca 33360 
           gaatccaaat atgtgaatgt aagatttatg gggaaattat ttgtatttca aaataatcct 33420 
           taatgaatgc actccttcta aagtagccat taataaagca gttaatgttt catttaatta 33480 
           tagattaatg tacataagat atgccaggaa tgcaattagg aactgggaag ggggtgttat 33540 
           tctaataact tccacatagc attgtgagac atttctgct ttcttcaaat ttcatttaat 33600 
           tacattttaa acaaatattt ttgtgagcct attatatagt ccttcgctag cactgaggag 33660 
           acatgctttg tgaccttggt gatttcacat tcaaatttcc ctttcaccta cactcttcct 33720 
           tgttttttca tgcctgtgta gattgtaaat tcttcctcag attaagacat tttatcacc 33780 
           tttgtaacat ccacagtatc tagcacaatc agtgccttca aaaacaattg gcctcaagaa 33840 
           ttgattgact caatgagtga ctgaaagact aaattaataa gtacacatct atttgtactt 33900 
           ccctgcttac ttataaggta tgacaatgaa atactgagac agttatacat tacttacgga 33960 
           ctcaatctca tttctttaca atctctattc ttcttttttg agtataatgt tattttacaa 34020 
           ttccactaac ttgtcactct ttattataaa ttcatatctc catttcacct gagaataata 34080 
           aaggcaagga agtattttaa atgatcttgt tttttataac tagcattcat tgagcaaatc 34140 
           aaagtatgaa aataatatag gtgtcagtga ttattataaa gttgtatgca caaaacattc 34200 
           caatgattgg ggccaataca gagaaaacat ctcaatattt ggaattttgc ttttctgtaa 34260 
           atactttgat atgtacttac atcatatcaa ttataactcc tgctgaaaac aaacagtgca 34320 
           cacaaatttg gtagttggag gagactttat aaagggacta attacgaagg tttagaccgg 34380 
           gttaggaaaa acacacggaa tagtgcaata ctttaggatg gcaacagcga gcaccgttat 34440 
           aacccatagg ccaaaatgaa ctaaatgaac aggggagatta ccatttatca gaaaaagagg 34500 
           gagaaaggaa ggagagatga ccaagcaagt cctatgtgaa gacggctgcc tgacttgagc 34560 
           tgtgtgatct ttggactgat accacctgcc tgcactggcc tagcagggcg agaatagtca 34620 
           atatctggaa aatggatcac ctgaccttac tttcctccct ccctgtttcc tctttgtggt 34680 
           gtttccactg gccaaactca cagcgtagac aaaaggagtg cattgatgta gcagtggttc 34740 
           taatccagggg ccaattgtgc tcccagggaa cattagtggt tatcacagct caggggagga 34800 
           aggggagagga gtggagtgct actatgattc actgagggat ttttttaaac atctacaatg 34860 
           cacaggacat ccttccacaa caaagtatcc agttaaaaaa tgtcattact gccaaggttg 34920 
           aaaaaccgtg gtgtagtcag tacaattcat cttctccagg cacagtgcag gagtggggtg 34980 
           gagtgtctga agggggaagaa ggaagaaacc agcacacccc acaaaagtaa ccaatgcaaa 35040 
           taccaaatag gaaaagacag cacttaaaat acaaaagtct caggaatata tctgatagtg 35100 
           ttttatggaa tttattaaaa tttagcctgg agtgagtaat atttagcaag ccaggtttgt 35160 
           ctttagagaa atccttgtgg ggtttataca aggatttatt aacaaagggc acacacaata 35220 
           ctcatattac agtcagtctg gttatgtaaa acatgggcaa gaatgtaata ggacaatgtg 35280 
           atgtattcac aaaggatttt aggactacac agataatcct ctaatgcttt cacttacgta 35340 
           ctatgaaagg ctatagtttg catagtgata tagccacgta agatagtaaa cttgacattc 35400 
           atgcagctat acatgtttgc acacacagg atgcatgccc tttctacctg gttgattttt 35460 
           tattctttta ttaatctcta atttattccc cagaacactc tccataaaaa ctttctcaca 35520 
           acttaaatct ttaatctatt gtgtggattt ctgactcatt ctccaagctt ttcctcttcc 35580 
           ctccgcaatg ccttatagtc ttatgactat ttatcccttt gcctacattt ctagccagat 35640 
           ctcttgcctg atacacactc tcatatttct ctttgcacgc tacacatttt tattagata 35700 
           tcacactact actttgattt caacaggtct cagtttaact taatttttcc ttcaagcaag 35760 
           gagtcccttc atatcagtta tcaccattgg caccagaatt tttcttatga cttcccatga 35820 
           cctacaatat aaaccatata aatcactgat gcctccatag ttccctccct ctcaaattta 35880 
           gccataagat gattttagga tccttgtttt ttccaatctc tctttcattc tctcccccat 35940 
           ctcttccatt atgaaggttt gtagaggaca caactcatgc ctagattagt gcaatagatg 36000 
           ctgagcctgt gcagcggtag tttagctttc tctcctggtt aactttaact gccacatata 36060 
           tcacttcaca cgtcattttt cattcaaacg tattaactg gctcttcatt cataagaagc 36120 
           tggaatttgt cgtttgactg atattttaaa gattttatat tttttctcca tcctcgttct 36180 
           aatgttgtat cttgtgtcat ttgttcattc ataaacttaa gacttagcta accactgagc 36240 
           atccaggaaa ttcagtatct atcatgtgaa ttctctaata ctggttgatc cattgtcacc 36300 
           agagcatagc aggcttctcc tgcctttatg tatgtttgtc atatagttca tgcctaaaat 36360 
           tctttcttaa atcttaaatt cctaagatac acacttttgc ccaagatcac agtaatctct 36420 
           gccataatct ctgctggaat ctgttcactg tgttgctcct gctaaacttc ttacagatga 36480 
           ctttttttct ttttggtttc cctggtatct agtataattt cttatatagg tactcaataa 36540 
           atgtttcctg ttgatctcta cacctactct gtacaatacc atagtgacta gacacatgtt 36600 
           gctatcaagc atttcaaaag tagctagcct gagttgagat ataggggtaa aatacacaac 36660 
           agatttcaag acatattatg aaaaaaaccc ataaaatttc tcagtaattt ttttatagat 36720 
           tacatgtaga aactataaca ttttgaataa gttgtatcaa ataaaatata aaattcaccc 36780 
           ggttcttttt aatttgttaa atgtggtggc tagaaaattt aaaattacat aattggctca 36840 
           cagaataatt ataatggatg gtattgcttt agatcaagtt tgtctaaccc gtggcccatg 36900 
           ggccacaagc ggcccaggat ggttttgaat gagatccaac acaaatgtgt gaacttcctt 36960 
           aaaacattat gaattttttg tttgttttgt ttttgtttttttctcatcag ctatcatgag 37020 
           tgttagtgta ttttatgcat ggctcaagac aattaattct tcttcaaata tggcccaggg 37080 
           aagccaaaag actggacaac cctgctttag atagtaaagc atatgagtag ttaatgtgta 37140 
           ctataagcag tgtgatctga tagactattt aatgttgttt gatggtacat tattcaagtc 37200 
           gattattatg tctacctatg cagtttaacg acggtaatga gagagggcag cttgattaca 37260 
           ggtcttatct tttgactaac ttgctaggcc acctgagaag gacccaaatt atctgaatgc 37320 
           ttaactcaac taatttgtat tcacttgaag aatttcaagg atgtttatat gccatcaact 37380 
           tgctttaaat tttttctctc agtgaaaatt tttcttaaaa tgagtatgtg gtattcaaat 37440 
           ttatccttgt tttctatgat tatcttttca tagcactgtg gtttccagga accttttttt 37500 
           ttttgagatg cattctacat gtaactattg cacagtttgc atgtagtaag gttcattatt 37560 
           cttctacttt tccaaacacc tggcatgttt acttgaggtt ggtacacctt gtatcccaga 37620 
           ttttgctgtt tttaacttaa atattgaata ttttgattaa aacttatgga aagtttaaat 37680 
           gggtcaagaa aaatagcttt tcttcccatg aagaacaata cggcatagga gttaagagca 37740 
           tagatttaaa gtcagaaaac ctgtgctgcc tacttgtgca aagtcactta catgctgtac 37800 
           ttctgtttct tcatctgtaa gttctacccc taggtattta cttaagatta atggaagcat 37860 
           atgttcatac aatgacttgt acagaattat tcacgatagc attactctta atagctctaa 37920 
           ctggtaacaa cacaataatc aatcaacaat tgtgctgtat tcatacagca gaatactact 37980 
           tagcaacaaa aatggaatgg actactgata acctcaacaa catggatgaa tctcaaaact 38040 
           atcatgctgt gtgatgccag gcacaaatca gtacataacta taattccaga aaagacaaat 38100 
           gtcatccatg gtaacaacaa gatccatgct tgctggaggt agaggcatca gttcagtcat 38160 
           tcaggaagct gattccaaga tggtgttaga attacaacca tccacaagag atttattgca 38220 
           ggcaatagct atgaaaggta gaaagagaac aggagaaaaa ccaggcaagg aaaaaccaca 38280 
           atgtagttgt gatatcactt caaaggggagg cagaaggaag gagaattggg taggaatagc 38340 
           cacagattac agtgcagtta caagaaagtc ttggcttcca acaaaggtta cttgttgagg 38400 
           agtcatgcat taggcagaca tgtctgggct gtagtttcct tgctgctccc agtcattggc 38460 
           tggaggccag tctgggttcc tgtgctgtgg tggatcccat tgctgctgca gcaggaggcc 38520 
           aatagcactc ctggcagcta attggagaga aaagatccaa gaggtgtacc ttcatggcta 38580 
           cccccatggg gctggggtgg aggtggagga gaaggagaag gaattaacta gaaaaaggca 38640 
           caaaggaaaa ttggggaaaa taatgaagat atatgatttc tcaattgtgg tggtcgttac 38700 
           atgggtttat taatgcatca aaactcaaga aatgtacatt taaaatgagt gcatatgatt 38760 
           gtaagtgaat tatacctcaa tatagttaat tttttaaaaa tcatagattt ctttatattt 38820 
           aatgcatgaa cataaaccta agacactcct ccactccaaa acttaattac cttgtgatca 38880 
           gcagagcaga aggtactttg tgatatatag gtagagaaga tgaagtcttg tgacatttaa 38940 
           caagggacag gaaaatggac cttgtcctaa gttaccaaac tgcaaaaata tcacctacaa 39000 
           aggctattca taacatacat tttcaagggg gttacaatat ttgcctacta taaaattttg 39060 
           gatctgtaaa ggggttaaat tatttgtgca ggggaataaa catcaaagaa acattaagag 39120 
           gtccagagaa gtaaaatagg aagggtcttt tggctagagg agatatttaa ctttcagaac 39180 
           atgtggaatt aagttgtatt gattatgatc tgatcttctt ccccctaaat ttgatcctct 39240 
           tcctgtaatc tattgtttcc atcatcttca actcttccct ttccctctcc cttgtccctc 39300 
           agttctagtc aatcacaaag tcctacagtt tcactttctg tataccttat ttctggaatt 39360 
           catctctaga cttcaaaata tatatatata tatttttttttttgagatgg agtctcgctc 39420 
           tgttgcccag gctggagtgc cgtggtgcaa tctcagctca cagcagcctc tgccaccag 39480 
           gttcaagcga ttctcctagt tcagcctcct gagtagctgg gattacaggc atctgccacc 39540 
           acgcctggtt aatttttgta ttttcagtag agatggggtt tcgccatgtt ggccaggctg 39600 
           atctcgaact cctgacctca ggtgatccac ccgcgtcagc ctcccaaagt gctggaatta 39660 
           caggtgtgag ccactgcttc cagcccaaaa tatcttaagt agataattgc acgactaatc 39720 
           tctgcttttc tctcccagca gccttccaaa ttcatgtctc acagctgaca gagttgttcc 39780 
           tgccttcaga ttcatgacct ggctctgtgt tctagctcag gctttctctc tcatatcacc 39840 
           tcttgcctct ctgttgcccc catattttcc cctctggttg gttggtgctc ctttggaacc 39900 
           ctctgcatat cttttcaaga atattatgac ttattatgcc tataaacttt gtttaattat 39960 
           ttatttctaa aatttgacag ggaactttcc gaaggcaggt attgtgtctt tctcatttaa 40020 
           aagcaaattc tcgcctggca tggtggctca tgcctgtaat cccacacttt gggaggctaa 40080 
           ggtggacaga tcacttgagc ctaggagttc atgaccagcc tgggcaacac agttagacca 40140 
           aaaaaaaaat atatacgaaa attagcctgg catggtggca cacccccgta gtctcagcta 40200 
           gtctggtagc tgaggtgaga ggatcacttg agcctggatg gttgaggttg cagtgagctg 40260 
           tgattgtatc actgcactcc agcctgggca aaaaagtaag atcctgtctc aaaaaaaaaa 40320 
           aaaaaaaaaa ttagtgaatc ctcagtgttt aaaaagtcca taaacatact aaacatagaa 40380 
           gacctccaaa tgaaattaat caattattat ttagtgggtt gcttctcttt tgttttaata 40440 
           tagttttaac aaagagtaaa agttatgatc tttttatg taaaataaat aatgccgggt 40500 
           ttgacataaa ttttaggaaa actagagacg ctacttccta aaaattttct ttctataatc 40560 
           ttcctaaata tttttccata aagtacaaaa taatagaaaa aaattaagag attgagtatc 40620 
           ctttcaggaa gtgatatgac aaatagggtt cgagaactat ttgaattctc accacttttc 40680 
           ataagggcag atctcaagtt aaatttttct attcgaattt aaatgacttt cactggaata 40740 
           ccattacaga aaagcttctg tgtttagatg gcaatatgga gtttcttttc ttggaatatt 40800 
           aattgaagga gaagtcttaa ttttttaagt ctatatctcc gtatatattt gaacctattt 40860 
           tatatgttag tccttctctt tagtaacctt catccacagt gaacaagatt tacccttacc 40920 
           tttaagcagt agcggctact ttatgtgaag tgaacagctg ctttttttat ctgcatctag 40980 
           acatcaagta gtccagagtc ctttctaaca ccctagcaat agaagtaaga atattttgac 41040 
           cattccatga cttgatgata cttctagtaa taatactgta ttattaaaaa caaacaaacc 41100 
           tttgtgcagt ggtaattgaa gcagttcctt gggaacatgt attaagtact ttttagcagt 41160 
           taagtccact ctctgtaggt taaggaatat ttaaataaaa taatgtggca aatgagttca 41220 
           agatgataaa tgcgatgaga actaaaacag ctttaatttt atgtgggaaa taaatagagg 41280 
           aaaagtacat tacagggctc ctggacttat ttctttcttc aaagtgtttc tcctagcgaa 41340 
           tattattact attttttctc ttaagtaaaa aatacacaaa gtatgaatct acacaggata 41400 
           ataatattga agttaaggat gatgtctcct ccttcactct ccaaaatact atttacttgg 41460 
           cttcatggaa atctctctca ctccaattcc accgtgtcaa ctgaggtctt ctgttctttc 41520 
           tctccctata gcatattcct gttacataaa tcctaaactg tgtcgtgtta gtcacacact 41580 
           gtaacctcta gataagcgcc tgtccagagg ttctcaatca gagccttgca aatatgtatt 41640 
           aaatcaatgg gtcatcttca gtgtctcagt gggcccttgg atatgttttg cagactgctg 41700 
           tgagtatgta gggatgtcca gtatcgaggg aagtgtggat ggctttcatt ggttcttata 41760 
           gggctgaaga acacatagag cagtaagcac ttctactgta gggagagatc gagcttctcc 41820 
           catccccact gctggcacca ccaccaccct acaccccatt ttgagttctg aaagtgaatc 41880 
           cttgagaaag aacacacaaa acaaccatca taatagtggg cacagctgtg ggtggtagaa 41940 
           taacattccc aagcttcttt tcctacacat gattaatatt aattcagcaa aatttattc 42000 
           agctcctact tttaaacagg cactattcta ggtactaaag acatagaggc aaagcataca 42060 
           agactctgcc tttgtgaaac aattaagaaa taagtaaaaa gaaaagaaac agaaaaggca 42120 
           atttggatag tgtcaggtgc tataaagaaa acaaaatgcc attttaataa ataataataa 42180 
           tacaatgttt tcatactatg tgctagacac tatgctagta ggtatttata gacataacct 42240 
           caattaatcc tcaaaatggc atgttgatat caatacccca agtttacata tgagacttaa 42300 
           gatgtctgag tatattcccc caggtaacaa ttaatatgca caataaaact ttttgctcat 42360 
           tcatttatta acctatgttg attgagtacc tattttgtgtcaggcatcat tttaaggcac 42420 
           ctggatatag ttatgaacaa acaaataaaa atctctgccc tcaaataatt aatatctcac 42480 
           agaggttagg caaaatataa tcagaaaata agtataacgt ataggatgcc agatcatgaa 42540 
           agaagctatg aatggcatca agaagctgga aaaggcaagg agacagattt tctcctagag 42600 
           tctccaaaac agaacacagt cctgccgaca ccttaacttt aggctagtga gacccctatt 42660 
           ggacttcaga cttacaatcc cacaatgtaa taaatttgtg gtaattcagt agggggaacaa 42720 
           tagaaaacta atacgatatc aaaacaaatt atatcataga acaagaaaat gtaattgtga 42780 
           caaataatac ctacaaaaat gttgtaaatg ctaggcaaat aatgtgttta aagcacttag 42840 
           gccaatgttc aacgtaaagt aattcatgct ataatatcat catcatcatt accaatattt 42900 
           aggggctcta acaaatgatg tacgtgtaag cagatgtaag aaaatttcct tgctgaagag 42960 
           gaggttattaa tagagtatat aacaaagat aacaaattcc aaataaaggc aaactaaatg 43020 
           ttttattgga ttaaatttaa ttttaaaaac tacaagaggc cgggcgcggt ggctcacgcc 43080 
           tataatccca gcactttgga aggctgaggt gggtggatca cgaggtcagg agatcgagac 43140 
           catcctggcc aacatggtga aacgctgtct ctactaaaaa tacaaaaatt agctgggcct 43200 
           ggtggcgcgt gcctgtaatc tcagctattt gggaggctga ggcaagagaa tcacttgaac 43260 
           aaccaaggag tcggaggttg cagtgagcca agattgtgcc actgcactcc agcctggcaa 43320 
           cagagtgaga tcccgtctca acaacaacaa caacaacaac aacaacaaca acaacaacaa 43380 
           caacaaaact gtgagatcca tggtgggctt ttaagaggaa aatgcaagct aaggtttgtt 43440 
           tagactctga gtactgcatg tgtaaaaata aaggcatgat gaaaagatca agagattaga 43500 
           gtgatacttt ttatctacta gtgtcagagt catgaccagg ggattggcta tgagaataca 43560 
           taagctgtgc caggagtaat ccaaggagat tgtttcaatt tggaagagtg tccacagaat 43620 
           gattctcata ctagacgttg ggctattgta aagaaagttg gtaggtactc catcgctagg 43680 
           atcatatcag ggagaaattg aacaggatgg ccctaatgac cctgttgtac ccctagctta 43740 
           tggattaggc aagtcacttc tactcgtata ccctgtttcc ccatttgtaa ataagaggat 43800 
           gtgttactct aaggatctct aagattcttt gcagttgtta aattgcatag ctctccactg 43860 
           attccatggt ggaaatttgc tattctatta caaatattct aaatgtatga gatatcagac 43920 
           atactcattt aaaaaacaaa atacaaaaaa taagtattct acaaataaac acagataatg 43980 
           tttaaattct atatgtcttt gtttctcttc agaagcatcc aaaatacaaa ccatctaaga 44040 
           ggcaagaaaa tgtcgtgatg ttcctagtgc aagttaaaaa gatttgcttt cctcaagtcg 44100 
           gaaagccctt ctcatttttg aggttttttt cttcttttttttttcaagtg aaagcatttt 44160 
           ggaggagtca atatccatct ttaaaggtag ccaggtcaca tgtatacata tgtaactaac 44220 
           ctgcacaatg tgcacatgta ccctaaaact taaagtataa tttaaaaaaa aagaatttaa 44280 
           ataaaaaaag aaaatcagag agaaaaaaaaaaagatgcat gtgcaccctg atactaccat 44340 
           ccatagtgat acggtttggc tttgtgtccc cacccaaatc tcatcttgaa ttgtaacccc 44400 
           catgtgttga gggagggacc ttatgggagg tgattggatc atgggggtag tttctccatg 44460 
           ctgttctcat gatagtgaat gagttctcat aagatctaat ggtttaaaat catggcactt 44520 
           ccttttgctc tctctttctc ctgccatgtg aggtgtgcct tgcttcccct tccccttctg 44580 
           ctatgattgt aagtttcctg aggcctcctc agctatgcag aacggtgagt caattaaact 44640 
           tctttcttta taaaaaaaaaaaaaaaaaaaaaggtagcca ggtaaaaatt acttgtttcc 44700 
           aggacatttt cacctgaaag aagcattgtc atataacata gaagcaagaa atccagtagt 44760 
           ggggggttat taaaaatagc tggaaaattt caatcagcat gagtttgaag caacaattta 44820 
           tcatcacctt ttatggtggg tggggttaag aacatttcag cgggcaaagt ggtggtgatg 44880 
           gggaagagac accaggggag gtgattccca ttgcattgct ttgtaaacag aggcacaggt 44940 
           tcttcatttt tgtcacacaa aatcacagct atgcagaatt tattaattta ttcttctgag 45000 
           acaagaaaaa agccaccaaa ggaaaccaac agcttgctcc tctcacactg ggggaaccat 45060 
           atgagagact tatctatccc tgactttaat tttgacctga ggagagctcc tcttaaggaa 45120 
           aacaaattaa ttcaatgact atactactta atcattgacc tttattaat aagagatttt 45180 
           tccataggat atgctgagct gtctcactta catcagttgtgtctcctgag gtgggtgaca 45240 
           ggagaccaca aatattgcat agcacacaaa tcgttaatag cagctgtata ccaaaccatt 45300 
           acctaaatat gtagagtaca attcattctc actaatgtca gagagcatgc tataaaatgg 45360 
           tgaatccgga cagctgaaga tactgaataa taacctctat tttgaacaag tttacagtgt 45420 
           tccaatcagt aattaaattg atacctgatg aatatatgtg tgtgtatgta ttcatagcag 45480 
           agatggtttt cctgagataa ggattttgtt attcggatag gctgctgctg gaattgtcct 45540 
           tctacccttg tttctttgtc cttagtcatc actcatacct ctttccactc ttctgccatc 45600 
           acttttgtca ccaaagtcat ggtcctttcc ccgccgattg ctgctgcagg tctagggcac 45660 
           caagacttag gcagcactca ccatgtgcca agaactggac cacaggtacc atccagcatt 45720 
           gctcatggag actctgtccc tttctgtagg acaccctcct tttagctagc aacccctcca 45780 
           ccacctagag cctctggacc tctcatttta atattaagaa ctaggaaaac ttaccgctga 45840 
           gaataactag tacaactaga actggtagag aaatctgggt ctcttgggaa tggattttta 45900 
           ggctttattg attagaggtg tattaataat gcagtgttat agtttcatga cataacgaat 45960 
           aaaaaagttc attttggact tgcctttcag ctccctagga gctaaaagac gtatttaatg 46020 
           taacttgtgt ggtggaaata agttcttttt tcaggcaaaa gatgtgcaaa cccatctggg 46080 
           gaagaaacat taaaaactaa ggagacagtg tcctagataa ctatgttctt ttcctgtttt 46140 
           agtctaaaat aatgattagt tttcttatat atcttcattt gtcttggttc cttttagccc 46200 
           aatttaataa tattattgca gatattgatg aaaaccttta ccttcctctt aattcatcaa 46260 
           agtacttgat aaaatttata catagtacat taattgggag gtttttatga gattaattaa 46320 
           tataatgaac tgatgttgaa atttattaaa acctgaatta ttaattgtatt aagtaggaca 46380 
           cttaatacag ttaatcagtt ctgtctttat tcatttgtga gaatttttgg caagctattg 46440 
           tgaatattca gggaagggaa tgtattttta gcaggaatct tatacctcct acatagaaat 46500 
           gaagcattta ctgaaacatc catgaaacaa aatgtttctg aatgtgtact atacacttgt 46560 
           tataagcccc ttttcttctg tagctatatt ttggagaaaa atctttgctt tgacaaaaaa 46620 
           aattatgttg acttacacat atattttata actaagcagt gtttggtttg tgataaagga 46680 
           tacaaaaata taaaaatgtt cagcacacgt aagtaaggcc ttgttgacag tgtgagttat 46740 
           gctactggat actcaaaagg aacattcagt gttctcaggt ggtctctaga ctgtctcaag 46800 
           cctaggaaga tattttataa gcaaaggaat aagagaagga agattcagat ttaatccaag 46860 
           tgaagaattc agttttgtgt gccttatcct gttattttga gaggcagcca aaagatgctg 46920 
           gtcagcaagg agaattgtaa gttgggcagc caactctgat ttctcaacct cttagctgtt 46980 
           ttcttaaact cagaattttt aatgaattta aatgtccata tcaggtagac tttggggatg 47040 
           cttttaccag tgattttcag aatgttactt tctggcattt cttttcacgt agcattatat 47100 
           taaaaatgaa ttcattcatc caccttccct tgtccttact aattttccct cctactccct 47160 
           tcccccttgt tcttgccatg gggacatgca aacactggtg gttgatgtct gagcaaggct 47220 
           gctgacagggg ggaggaagga gatgtcaagc agaggtcaat ggcagtgtgc ccagcagcct 47280 
           aggaagtagg agggaaaaga gagagagaca gagatggtgg atgaaagaga aagccaggat 47340 
           gattatggtg gttatgatac ttgtcatgct gaacacccaa ttgagcaccc aataagcaca 47400 
           taataattta atcatcctct ggcttggatg gcagtgttct atcagtgttg acttcctggt 47460 
           tgtgacagtt ttacagtgtt agtgtagaag agaatccttg ctttagagag gtacttactg 47520 
           aagtacttag ggttaatgca ccattgtgct ggaaaaagat acgcacacac acgcacacac 47580 
           acacacacac acactctcac acacacgcac aaatacatcc atgtgttagg cagagggagc 47640 
           aaatgaggta aaatgttaac aattaggaat tctgggtgaa gtggatagag ggactctttg 47700 
           actgttcttg aaacttctct atacatttga tctgtttcaa attcttcaga aaatcaaact 47760 
           acaaaaactt aattcattta gtgaacatct actgaacatc tgtatattaa atagtgttaa 47820 
           atgaatgtca attaaaatgc tcaaacacag tagaggttga ttctcattca cataagtcca 47880 
           tggtaggtgt ttttggcagg tgggtgagtt tctcccttag ggagattgag gaacccagac 47940 
           tcctcccaag ttgcagcccc accgtcttct gaggggatgc atccataccc acttcgaagt 48000 
           agcatacatt atttcctttc tcattccttt ggataccagc cacaatttat tcaaggtaga 48060 
           cagaaaattg tagtatatag ccatatgccc tgacaaagaa gggagaacag attttggtgg 48120 
           acaactagca aactctgata caatctgtta ttaagcactg tgtgtggata gatgctaact 48180 
           agaaggagat tatcttccct tcagcaaata taaactgaat gccgtttatt tggttgaaac 48240 
           taagctagat catgggagta tagaaatttt ataagaagac atagtcactt ctgtcagtga 48300 
           gctcaagaag aattagtatg cggaatgtaa tcatacctac aggggggcttg tgccacttaa 48360 
           gtaaaatgaa acattatttt gagtacaatt tagcaataaa tgtactacga gatcattaaa 48420 
           aatcatgttt gaatgttatt gtgtcaagga tgggaaaaag acttttgggt tgtagacttg 48480 
           ataattatag ttaaaaacag tttttattct tgtttagtcttattttttat gtttaaacat 48540 
           atttatactt gctaacattt atacttgcta agtaaagact gtttttacaa ccatgacaag 48600 
           aacaaaacat attagtaatg caaatgccac atttcctaca atcaactaat cacactaaca 48660 
           tatttgcatg gaagaatcac tgggattgat ctggccacgt gtgtagtcat gcccaaaatg 48720 
           tgaagtccat ctgttttgca atttttttta accactgtta tccaaatgct ccttggattt 48780 
           tttttattag tggatatatt ttggaggtca gacaccctct tggctagatc atcaccttta 48840 
           taacaaatat atatactatt ctcatggaaa tatatttaga cattgcccta ctgggaattt 48900 
           ttttcaagta attaatgtac agcttgtgca acagcttgat cttggcttca tggaaataat 48960 
           tcactcttag cagcatctaa tgccacaaag catttatgga tgtcagctca gaacttactt 49020 
           ttattattct ctgagttact tttttttttttttttttgag acagagtctc actctgtctt 49080 
           tggcttgtcc ctaacctctt aacagactta atattaagct ccatttcact cagtcgttct 49140 
           gttgtcatat aaatgagaca ttctacaagc atagttttta gtttctgcca gagcatcata 49200 
           caacattgtg agctatgatg aagataaaga cctagagaag atatttaata tgaagttcat 49260 
           tatctaatat ttggtatgtg tggcaaaata gcaatctact gcttggttct gctgtaatct 49320 
           atttacccac ccatcccatc tttctttcaa tttaaaagga taatgatttt agtcacgatt 49380 
           atacataaac ccattaccat aggcaataaa caatggggca aaccattggt cccatagttg 49440 
           gagtgtggtc tgaagtgtgtgtttggtggag agagatctat gtctggagat agctaacatg 49500 
           gatttggatc ccagatctgc tcctacctgt tgctgtgcct gtgaccaaat catgtgatct 49560 
           ctctggtttc agtttacttg tgaataaagt aaataccttc atcaacacct gtttttgaat 49620 
           acaatgtttt tctgtaattt ttgcttctta taatgttata atgatcatcc ttacatctaa 49680 
           atcttggttt aattttcat caattctttt ggaaagattg gagaagtaaa ttttggagat 49740 
           gtatgtcggc tattaaaaat gtttaatttt ttaattaaaa attaaaacgt tgaaaaatcc 49800 
           tgatgcaaaa taaatgcatt atgcttagtg aactcttctc atttcgaagt ttatcacct 49860 
           tcttgttttt gcaagtttcc tgaaaaatgc atataaagtc actaagttag cagaacttta 49920 
           taaaattata taactatata taatcttttg atatcagtga agccagctga tcctatagaa 49980 
           ataatgtagg aattataatc actagcacat aatttaagag tcctgtggtc ttatcatgt 50040 
           tattaccct ctctgaatct tacatatagt aagagggtta ttatacataa tatgtgtaca 50100 
           tgtatacagg taagtaagta tatatgctta tgtgtaaaag cagagttatt gtgagagtca 50160 
           aatggaaatg tgaaagtact ttgtagtttt ttattactat tattaatttt taataaaatg 50220 
           gtaacattca tttaataatc attagtttta acttcagatt gtactggatt tcctctagta 50280 
           tttcttaaga ttagtgaata aagtatttct cctaataaat atattgacta ctgtctttcg 50340 
           atcaaacata ttaggtatat ttttacagta gcatcaggca gtgaaaattt gaagctcttt 50400 
           atagaggact gatttatgat gaaaaggaat aacatgaaca aatggaatta tatgaagctt 50460 
           ccccagaaat atctaagagg ggccaatttt aagaaatatc tgacttcttt ttcatggaca 50520 
           tttcaaaata aacctaactc atatggtaca gtttttaaga gggaaaagaa aaaaccatct 50580 
           gagaatctct ggaattctgc cgaaagtatc acttggcatt ttatctacc ttctggatgc 50640 
           agttgattga cagtagtgtt atgatgccag gggtatagtg actagaaaaa gaaaaccagg 50700 
           gaattcagtg ttcttgctca tgaagaacag cttggttctt taaaaacaat gagattttgc 50760 
           cacccccatct cacaaaccta tgatttgtga gaacaatccc ttttgtgttg caagactttt 50820 
           acatttctct tcccacacta tattagaaga ataaacattg cttcataagt accgattgat 50880 
           agtctcattt catattttta aaatagagtt actttaaggt taaatttttc atgtagatta 50940 
           aaatgactaa gtaaccattc acatatttca aataaaatat attttacta caaaaggaaa 51000 
           ataactagat tcttaagtgt tatagtcaag tgtaattgag taatatgaat tctaaatgaa 51060 
           tttctaagat ctgctcagct ttcactactt taggaaggaa caacttaaga aaaattttaa 51120 
           taaagatatc tcttcacaca catggcagtg ttgtacttag agaacatgac ccaaaatttt 51180 
           ttatgactgc atattgaatt cctgatactc ttgggaagct ccaaaagcac cagtggagtt 51240 
           tccagatgta actgtggctg cagacccgcc agtcccggtg ttggaaggga tcattatagg 51300 
           ctcttgtgtg cagactcatc ttcagaccca gaggaattaa ataacttgcc caaagtcgca 51360 
           caactttctc atggtaggtt gggcactaga ataaatattg ctttttctta agagttttag 51420 
           cctccgtatt atgaaatctt ctatgttctg ctgatgatat ctcctttctt catctgtttt 51480 
           ctatttttaa gcaatggaaa tacaaacttg caactcccca tttccaacac aacttagaaa 51540 
           aaacaatatt taaagaaaaa attacaggca tctcatctcc tttacctgac agatgcttga 51600 
           tagtaatggc ctctagatag ggatgacatc taatataaat gtgtcctttc aagtcaagct 51660 
           ttctctgttc attagtagaa atattgtata tcaagtgtgc aaaaattttc ttcaacaggg 51720 
           agctttgttt ccctcctttt attataacaa tctgagcttt gtggtcccag ggtctcctag 51780 
           tgcctgtctt taggtctgtt tatcacatg aagaaagcat gtcatatagt attatctaag 51840 
           actcaggctg cttatgcatg atgacagaag ggttcccagg cacaaacatt catccatgca 51900 
           ttcatccatc cacctattca tccatgatt tggctgataa ttatgacta ctgttgagtt 51960 
           gccctcagat ttagtttctg tccttctgcc atggggaaat atggggttaa gccacaacat 52020 
           actcttctct tctttttctg caccttctta gtatatttag ttccattttg tctagccctg 52080 
           cctctgactt ctttgttgta cttcaggttt tttatcattg aaagttatt ctggatcata 52140 
           gatcattctc ttggtcactt tgcttgttca cttataaaat taattcagaa aaaatgaccc 52200 
           acagtaatta ccgtaaatca cagaccataa actataatac tgtatattgt attagtac 52260 
           agaaatattt atactttaaa atgttttaaa tatagatatt ataaaaagat atgtctcata 52320 
           taagtaatat aaatactttt ttattaccctc ttctctccct attctccagg ccagtgtttt 52380 
           aaaaatccat ctttatatgt ccatcctgga aaaaactcat gatcataaat gagtttctca 52440 
           atagagttta taagcccaca gttgaaacac aattgtctta gcatccatt agttgtcata 52500 
           cttttaagat ttaatggcaa atattatgtt ttgtttcttc aaaagaaata ttttaaaatt 52560 
           ttagtaaagg cagttagaga aggtagagat aatggactgt ttaatcctac ttttcatccc 52620 
           acaagtgaac aaaaaaatga taaaacattt ttcccaaaat gtagctttaa ctatacttaa 52680 
           atttggacta aaatgggaga tatcttttct actattgaaa agccgtgtct gtagattaat 52740 
           gctaaaatcg ggtgtaaaag caaaatttgt ttggcttgat tgccaatggc ccattcattt 52800 
           ggctacagaa acaatagcac atagcaacag ataatgatgt gagatcacct agctcaagta 52860 
           agagtgtctg atccgtcaaa aatatataca tcaagattca aaagaaatgt gtgttttctc 52920 
           aagtcatctc tgtaaaaata cattaaatag aggaatagaa gtttgacttt gaaaatacat 52980 
           tgcagaccca atccgtcttt cctattttct ggtgaaaagt atcaaatatg tggaacctgg 53040 
           aactgctatt ctccttctta aaaatctttc ttaatattct attgataact ggtgcaagcc 53100 
           taactttttg tcttacccga ttcttctcac accaaagtga taggaccttc aggtagcctt 53160 
           tggatagaag ataaataata atttaactat tgatggaagt tagtattaga attagacttg 53220 
           gaagtctatg gaataaaatg attctacaac aatttgtact tcagacatta gtataaaaa 53280 
           acatgtttgc ccgtgcatgc ggaaacaacc aatttcatgt ggatgcttat attcacaaag 53340 
           gagtaaccac ctggggtttc ccactgttgc tccagagaaa actagcagca ggagaacttc 53400 
           tctgaaggta tcaagacatc tttaaaaaac acttgttaag tgttggttca gctaaagcag 53460 
           ggagttttca gttagtaatg gcttttaaaa attaaaacaa gtttagcatg taggtcatta 53520 
           accttgaatc actgtcatga ttattattaa ccatctgttc tcaaatcgaa agatattttt 53580 
           cttttctaga tcacatttat tctcacattg ctcaatttca ctatatatca agacatgaaa 53640 
           actgtaaaaa tcacaccttc tacatttatta tttttatga aaaattccta atgaaacagt 53700 
           gcgctctggg atagagaaag gaactaactg aattttgct tcttaacttg tttttatgca 53760 
           agttctaagt ggtttctggc catgtacata aaagacaaat atctggaaaa aaaactagca 53820 
           gaagtcagtt atttggctct atctactttg agaattatgt tatataaatg ttaggaaatt 53880 
           ttttgtaata ttcttattta gaaatgaaat ataaaaagtt ttaaaaatat ctaaggacag 53940 
           tatacagtcc taaagtaaag ctgttaggta aatgctacac aatcctctta ttacagagtc 54000 
           acttacctga gaatataaga agagggcctc ttgtttaaga gtaaatgtga gctgcaatca 54060 
           ggattctgca ctcatttgga cacttagttt tgtttttcca tgactggtgt tgcctgttac 54120 
           tgagacacct acctgtcatg tgaccacagc ttatgttaca atgtgtctag tcagacttag 54180 
           agatgtgtga aagagcagta cctagacggg aaactatggg tctataaagg ttttgccttc 54240 
           ttgggcggag ttcaaactag gaagccacaa aacttccagt tgcattttca cagattaatg 54300 
           aaatatattt tacacttttc ctgaaagata ttttatttgt gcaaaccttg ttacaaagta 54360 
           cagccagttg attaatcgat gaagtgattt gtagtggatt cttatatttt gtgtaagggt 54420 
           atatgtgagg ccctatatat gaggctttct atataatgaa gtataattca gttcagcatt 54480 
           tcaattcagc aatcacttat tgggcctcta ctcagttgcc ttcagggctt tataatttaa 54540 
           ttgataaagg gaggttaatt aattaattat aacaacagat cgcttaatag tgtaactact 54600 
           aatttaatta atgacaaata acaatacatt aaaagaaatg cattaataaa aataatatat 54660 
           tggtgttata gacaataatt ttctgattaa ctttaattatt attatttcaa tagcttttgg 54720 
           ggagcaggtg gtttttggtt atatggagaa gttgtttagg tatgatttct gagattttgg 54780 
           tacactcata acctgagcag catacactgc acccaatgtg tagtctttca ttcctcacct 54840 
           tcctccccacc cttcccctca agtctccaga gtccattata tcattcttat gcctttgcat 54900 
           cctttagttt aggtggcagt tataaatgag aacatgtaat gtttggtttt ccactcctga 54960 
           gttacttcac ttagaataat ggtctccaac tctatctacg tagctacaaa tgccattatt 55020 
           ttgttccttt ttatggctga gtagtattcc atagcatcca cacacacccc cctatgcttt 55080 
           atatatatat gtaaatatat cacattttct ttatccactc attggttgat gggtatttag 55140 
           gctggttcca tatttttgca attgtgaatt gtgcagctat aaacatgcat gtgcaagtgt 55200 
           ctttttcata taatgacttc ttttcctctg ggtagatacc taggagtggg atcgctggaa 55260 
           caaatgattg ttctactttt agttctttaa ggaatctcca taacttttcc atggtggttg 55320 
           tactagttta cattcctacc agcagtgtaa aaaaatgttc cctttttacc acttccatgc 55380 
           caacgtttatttttttattttttaattatg gcaattcttg caggagtaag gtggtatcac 55440 
           attgtggttt tgatttgcat ttccctggtc attaaagatg ttgagcattt tttcatatgt 55500 
           ttgttggctg tttgtctatc ttcttttgag aattgtctat tcatgtcctt agcccacttt 55560 
           ttgataggat tatttgttttttcttactga tttgtttgag ttccttgtag attctggata 55620 
           ttagtccttt gtcagatgga tagtttgcag atatttctcc cattctgtgg gttgtctgtt 55680 
           tactctgatg attatttctt ttgctgtgca gaagctttat agttttaggt cccatctatt 55740 
           tatctttttt gttgttgttg catttgcttt tggtttcttg gtcatgaact ctttgcttaa 55800 
           gccagtgtct agaagagttt taccaatgtt atcttctata atttttaagg ttttgggtct 55860 
           tagatttaag tctttgatcc atcttgagtg gatttttgta taagttgaga gatgaggatc 55920 
           cagcttcatt cttctacatg tggcttgcca attatcccaa caccatttgt tgaataggat 55980 
           gtcctttccc caccttatgt ttttgtttgc tttgttgaag atcagttggc tgtaagtatt 56040 
           tagctttatt tctggatttt ctattctgct ccattgatct acatgtctat ttttatagta 56100 
           gtaccatgct gttttcctaa ctatagtctt gtagtatagt ttgaagttgg gtaatctagt 56160 
           gcctccagat ttgttatttt ttgcttagtc ttgctttggc tgtatgggct gttgttttgt 56220 
           tccatgtgaa ttttaagatt ttttttcttg ttctttgaag aatgatggtg gcattttgat 56280 
           gggagtcgca ttgaatttat agattgtttt tggcagtgtg ctcattttca caatattgat 56340 
           tctgccaatc catgaataag ggatgtgttt tcattagttt ctgttgtctg tgatttcttt 56400 
           cagcaatatt ttgtagtttt cctgtagaga tcttccacct ctttggttag gtatattcct 56460 
           aagcattttttttttttgca gctgttgtaa aaaggctcaa gttcttaatt tgattctcag 56520 
           ttttgttgct gttggtgtat agcactggta ctgatttgtg tacattgatt ttgtatctgg 56580 
           aaactttact gaattaactt atcagatcta ggagcttttt ggatgagtct ttaggttttc 56640 
           taggtataca aacatatcat cggcaaagag caacagtttg acttcctctt tagcagtttg 56700 
           gatgctcttt atttctttct cttgtctgat tgctctggct aggatttcca gtactatgtt 56760 
           gaatagaagt ggtgaaagca ggcattcttg tcttattcca gttctcgggg gaaatgcttt 56820 
           caaattttcc cccgttcaat ataatgttgg ctgtgggttt gtcataagtg gcttttatta 56880 
           ccttaaggtg tgtatcttat atgccagttt tgctgagggt tttaatcata aagcaatact 56940 
           gaattttgtc aaatgctttt tctgcatcta ttgagtttat catatgattt ttgtttttac 57000 
           tcctgcttat atggtgtatc aatttattg acttgcatat gttaaagcaa ccctgcatcc 57060 
           ccggtatgaa accccacctga tcatggtgga ttatcttttt gatatgctgc tggattcatt 57120 
           tagctagtat tttattgagg atttttacat ctctgttcat cagggatatt ggtctgtagt 57180 
           tttctttttt tgttatgtcc ttttctggtt ttgatattag ggtaatactg gcttcataga 57240 
           atgatttagg gaggattccc tctgtctcta tcttttggaa cagtttcaat agaatttgta 57300 
           ccaatttttc tttgaatttc tgatagcatt cacctgtgaa tccatctggt cctagacttt 57360 
           ttttgtttcc tgacattttt tctattattg tttcactctc actatgcatt attggtctgt 57420 
           taataatttc tatttcttcc tgttttaatc taggagggttt gtatatatgc aggaatttgt 57480 
           ccatctcttc ttggttttct agtttgtgta cgtaaatgtg ttcacagtag tcttgaataa 57540 
           tcttttttattctgtggta tcagttgtag tatctcccat ttcatttcta attgagcttg 57600 
           tttagatcttttttcttgttttcttggtta atcttgccaa tggtctattg attttgttta 57660 
           tcttttcaaa gaagcaggtt tttgtttcat ttatcttttg tattgtattt tgtgtttcaa 57720 
           ttttatttt ttatttattt atttttattt ttattttttg agatggagtc tcactcttgt 57780 
           tacccaggct ggaatgcaac agtatgatct tggctcactg caacatctgc cttccaggtt 57840 
           caagtgattc tcttgcctca gctgcccgag tagctgggac tacaggtgcc tgccaccaca 57900 
           cctggctaat ttttgtattt ttagtagaga cggggtttca ccatgttggc caggcaggtc 57960 
           tcaaactcct gacttatggt gatccgcctg ccttggcctc ccaaagtgct gcgattacag 58020 
           gtgtgagcca ccacactaag actcaatttt atttatttct attctgatct ttgttatttc 58080 
           ttttcttctg ctgggtttgg gtttgctttg tcttgttttt ccagttccta gaggtgtaag 58140 
           ctcagattgt ctatttgtgc tctttcagac tttttgatgt agatatttaa tgctatgaac 58200 
           tttgctctta acatggcttt tgctgtatcc cagaggttgt gtaggtttt gtcatttatta 58260 
           ttgttgaatt caaatatttt taaaattttc atctttcttg atttcattgt tgacccaaag 58320 
           atcattcagg agcagattat tcgatttcca tgtatttgta tagttttgag ggtttctttt 58380 
           ggagttaatt tttaatttta ttccactgtg gtctgagaga atacttgata taattttgat 58440 
           tttcttaaat ttattgagac ttgttcatat ggtctgtctt ggagaatatt ccatgtgttg 58500 
           atgaaaagga tgtagttgtt gggtaggatt ttttgtaaat atctgttaag tccatttgtt 58560 
           ctagggtata gtttaagtcc atgtttcttt gttgactttc tgtcttgatg acctgtctag 58620 
           tgctgtcagt ggagtactga agtcccccac tattattgtg ttgctgtcta tctcatgtct 58680 
           taggtctagt agtgattgct ttataaattt gggagcccaa gtgttagatg catatacact 58740 
           taagattgta aatttttcct gttgaactaa ttaattttatc attatataat gtctctcttt 58800 
           gtctttttta attgttgttg ctttaaaatc ttttttgtct gatataagaa ttgctattct 58860 
           ttctcacttt gagtttccat ttgcatggaa tatctttttc caccccttta ccttaagttt 58920 
           atgtgagtcc ttacgtgtta ggtgagtctc ttgaagacag cagatacttg gttgatggat 58980 
           ttttatccat tctgccattc tgtatctttt aagtggagca tttaggccat ttacattcaa 59040 
           cattagtatt gaggtatgag gtactgttct attcatcatg atagttgttg cctcaatacc 59100 
           ttcttgttgttgctgttgtt aattgtgtta ttattatttg ggtcctgtta aatttatgct 59160 
           ttaaggaggt tctattttga tgtattcaag ttactgtttc aagattaga gctcctttta 59220 
           gcatttctca gtgctggctt ggtagtggca aattcagcat ttgtttgtct gaaaaagact 59280 
           ttatctctct ttcatttatg aagcttagtt tcactggata caaaattctt ggctgataat 59340 
           tattttgttt aagaggctaa atatagggcc caatctcttc tggctagcag ggtttatgct 59400 
           gagaaatctg ctattaatct gctatgtttt cttttatagg atacctgatg cttttgcctc 59460 
           acagctctta agattctttc cttcatcttg actttagaca acctgatggc tgtgtgccca 59520 
           ggtggtaatc tttttgcatt gaatttccca ggtgttcttt gtgcttctta tatttggata 59580 
           tctagatctc tagcaagact aggaagtttt tcttgattat tccctcaaat aagtccttaa 59640 
           tgaccccact atataacatg aaatatctgt tattggtact gaggtgctgg ccacaaacaa 59700 
           ttctgtgtgt cctgaaaact cttcagaata ttcgtcatct ttagcacttg ttatcttagt 59760 
           gtttgggctt ggcttagagt gatacatctc ataacagggc aacagaaaga accaggaacc 59820 
           aagatttata taacataagt cagtaaaact agaggcacca gaggtttaca tttacattag 59880 
           gttacatttt ctaacaggta gcaaagcaca tgaatgaagt tcagtggaag gccttcctca 59940 
           ggaatccagt aaaaaccaaa catacacaca caacacacgga catccgtgag gcaggaaggg 60000 
           atgtccacta tagtacagac aagcatcctg gaaggccatc aaggagtagg tgggtttcag 60060 
           ttgcctcagg aatgtggcat ggacccaaac taagtgagta cagatacttg tcattgagga 60120 
           gaagattcaa aatagcatcc taggtgtaaa aactgaggca cctggggcag gggaactagg 60180 
           tctctggaat gttggcttaa aagcacccct ctcaggaaag gcctcatatg ccatgcaggg 60240 
           ggttatatat gtgttgtggg acagatgg caaggagata attctatgca ccaggctcca 60300 
           ctactaacag gtaaacagac caacattaac agagacttag gtaaaaaggt aggtgcccag 60360 
           tggtcagttc tcaggcactt ccaagatgca cctaacagaa atgtaacttg gtgtctattg 60420 
           tgtcctaggt ctaacaactg aagagaagtg aattagtacc tcttgtggac agagaaacag 60480 
           gggcagagac ccattacaaa gctgtctcag ataggcattt gaagctgttt aagtatgtag 60540 
           aggcttaagt caggctggtt ctgaaatgtg agagagggtt aagcttcatg ggaaatcagc 60600 
           agggtagttt gctatttttt attataacca atctcacaat agtttgggac atcaaatatc 60660 
           aaattgttgg gaatattat ccatattagt ctttttgcca ctaatatta aaaatagttt 60720 
           acaatataca acaaaaagtt gtaaaatttc catctccact taatcgatct tatgtaaccc 60780 
           atacaataca tcaaatgtcc tttccccact ttatgttttt atttgctttg tcaaagatca 60840 
           cttggctgtt agcatttggg tttatttcta ggttctctat tctgttttat tggtctgtgt 60900 
           gcctattttt ataccagtgc catgctgttt tggtgactat ggccttatag tatagtttga 60960 
           aagcaggtaa tgtgatgcct ccagattttt ctttttgctt aatcttgctt tggctatgtg 61020 
           ggctcttttt tggttccata tgaattttag gattgttttt tctagttctg tgaagaatga 61080 
           tggtggtatt ttgatgggaa ttgcatttaa ttgtagattt ctcttggcag tattacccag 61140 
           gcttttctta ttttggcacc ctgtgctgct gtctcctttt ccttctttct gcttctctta 61200 
           accaactgtt acctacactt caatactttc tgagggcaat tcatcctcca gtaagtctcc 61260 
           ctgaatcttc tcttccttcc ctggcttatt atatatcctt cctcttggtt cccatagcac 61320 
           ctatgcacac ttctgtcatt gcacttgcca atttgtttta taatgatctg ctcatctgtc 61380 
           tcctcactta gactatgagc tcactgagag caatggctgt tgcattcacc ttatatcctc 61440 
           aacaccattc tgaaggcaag agaaagaata cccagaggtg gagctgggaa gctggttgtc 61500 
           caagtagtga atgactctag tttgaattga actctatagc cagtgggcaa tgtggatgtg 61560 
           ttgacagttt tttaacaggg gactagtgaa aacacatttt gggtttagaa aaaattgcaa 61620 
           gtctgatgac atacatagga gaagagatta gagataggaa tttcacttca gaaatttaac 61680 
           cacaagagca agtgacagat cacggaagtc tgaaccagac tataaatgtg agaatagaga 61740 
           aaaaagttaa caatttgggt gtgaaagggc gagggagaga ggtgtgaaga atgactaagt 61800 
           gtggatctgt ttttaaggat tgaatggaaa tttgagcatt ttagctaatc aggcctaata 61860 
           ttgagcaaag caaaactctt gcaaattgtt atttcaagtg tgggctgaga aaatgaaaaa 61920 
           atataaattc tcacgttata acctcttccg tgtgtctgat ttgatagaat ccagccccat 61980 
           tgcctccaaa ttccattgca tcttagacca gcaaacacaa gtgaattcta cttaacccca 62040 
           gaattctgta tgaaaatctt actgcctttt tttttctaat catgtgtcaa agtgtgggaa 62100 
           gaacttttat ttatgtttta ataaattgtc agtataacca tttttacttg aaaatattat 62160 
           aatttttcaa gtaaacaaat tgtttctcta agttgaaaat tttatgatgg aataaaagta 62220 
           tttttcctca aaacacatag aaattttaca acaatatttt agagttaact aaatgtttct 62280 
           ttagtagttt agtcacttaa aaagtgatat gattatgaaa atacttaaac tttgtctttt 62340 
           aactatttct aataatgcta ttggtataat ttcatatttt tatactgatc ttttctccaa 62400 
           actttagtaa aacatacttc tgtaaaccccc tgcccacaaa actgaagtcc acattactt 62460 
           ctgaatgact gataagtttg taaaagtatg catgaatttc gttattaaat taaagttttt 62520 
           attatatttt atgcacaatg gtataaatta ttaaattaat tttcaagctt atagaacatt 62580 
           gataaagatt gtcattagaa aaccctgagt tgattgttat acattacata acctttcatt 62640 
           ggtggattag tgaatatgtt atagggtgac catgaatcca aagaatcaaa gctggctaca 62700 
           gcaaacagag ggtcaaaagg atatggaact atgcatgatc cagcaaaaca ctcaatatct 62760 
           gttttcctgg aatgttaaaa gacaaagaag aaaacttggg gaacactaga tgcatatagt 62820 
           tctggttctt taagaataaa aatatgggcc gggcccggtg gctcatgcct gtaatcccag 62880 
           cactttgtgg gaggccaagg cgggtggatc acaaggttag gagttcaaga ccagccaggc 62940 
           caacatagtg aaaccctgtc tctactaaaa atacaaaaaa aaattacaaa aaaaatacaa 63000 
           aaaaaaaaat agccagggtgt ggtgacaggc acctgtattc ccagctactt gggaggctga 63060 
           ggcaggagaa tcacttgaac ccgggaggca gaggttgcag tgagccaaga tagtgccact 63120 
           gtgctccagc ctgggtgaca tagtgagact ctgtctcaaa aaaaaaaaaa agaataaaaa 63180 
           caagaatggt cagagtccta gtaccttgtc cagtgtagtg ctgccttgag attgcattgc 63240 
           aatctgtctg agagatagta aaagaaagtg ataccttcct tagccctgtt tctctttaga 63300 
           ctatgctttc ccctctccaa gttaatatct ctcagtctaa agcctgggaa aaggtgccaa 63360 
           ttttgttttt ctttcttcct cacacctcct agaagttaca ctgggacact attacktttt 63420 
           tccaggcttt ggccatgtgt attgttttgg agagtcaact tccttttttc tttcattctg 63480 
           caaatagttt tgagctgtca ctctgtacta ggtgctataa aacttacagg tgcattttac 63540 
           atgcctattt cctataggcc acgatttaac aaaatgttca taaatgagaa ttaggagtgc 63600 
           atgtattgaa tcaccacaca ttaactgaac agctttcatt ggccagagac tatattgaca 63660 
           gtggagattc aaagataaac tagagaaatc tcatgcttaa ataactttct ataataaatt 63720 
           atataagaga agtaggttca gggatcttgg gagctcagaa gcaggatgag ttaaacaaaa 63780 
           gttggatttt gcctttagct tggtttcatt atcctgaagg aagagcctga aatatagtgt 63840 
           agggtgcaag tagtatatgt gggtggcaat ctcgggaaac aggagcatgt gatgaataag 63900 
           gagaaaaagc caatataaag gtactgcatt gagggcaatg agggctctaa ttctctgcac 63960 
           cttctcaagc attgtgcaga ttggttttct ggattatcag cctgaaggac aaaacgaaga 64020 
           aacagccatt agctcctgtc tcccattgtc tgagagctgc cactaggata ttaacttcct 64080 
           gaaattctgc agaaatctcc tcttactttg gcactggaga tgcccatacg cagaaagcaa 64140 
           aaaggcacag catatttaag gaagctcata agaaacagtg catccagaag tggcgagaat 64200 
           tggaggaatg gacatgagac tctaagaacc agcgcctttg atgttccttt tgatctgtta 64260 
           tgtagctctt cttgtacaca ggtgagcaaa ggcatgctgg acaaatggat tcacatgtgc 64320 
           taaagcatgg ggcaaaaacc acatattaat tcaggaaaag acaagatgcg tggccctctc 64380 
           tgtctctgtc taagggtgaa ttaaagaggg gatatatgta cagagtggca gggcaggact 64440 
           tgagataaga aggctaggtg ggtgctctca tgctagtagc attatagtac aggtgatgag 64500 
           aagctcctga agaatcatct taacatttgt attttagagc aacagtattg agttctgact 64560 
           tagagacagc aaaactaaag acagaaagac tattttgatt attaatgatg tagatataag 64620 
           aatatcgtca atgtgaacta aagcatgaag ctacttatga tatatcatta aaaggattta 64680 
           actgattgga gacaaacgag agggatgggg aaaagaattc atttgttttt agttgctctt 64740 
           tttttcctac ttattccttt gttccgagtg tgaataaact ttgtaaactt ttatactaaa 64800 
           acattctgct cattcatact tatttctttg atgaaacaag gaaacccttg tatagttata 64860 
           aacgtgtgaa tcaatttaaa tattaggaaa tttttttaaa taaagctagt tttctgaagg 64920 
           ggaaaaactt ggttcaattttttgctggca atctgctttg tgatttttga acatgattc 64980 
           tacatctaga ctcatgtttt gctagctgga attttttttc aaattaacgc taccattatt 65040 
           atatgcttta ctatttagct tttgcagcct tggaaatcta tgattaatac aaataattct 65100 
           ctatggcaat tttaaaaata catgtaaaag ccttcaatct aattgctac tgtgtcgtag 65160 
           cacaaaaaaa gaaaatgtga tcaaatttta ataaaatcta caatttattc ccttctaaat 65220 
           acagtcctag ctcaggagaa aggaagctat ttgtattttt cagaatcaaa tttccctaaa 65280 
           tgaatataga gaaagaatta taactgaaat attgttgaaa cagtggtcat ctcaaatctg 65340 
           aaggtcattc caaaaaagtt tctgagtttt cattgcctca atctaaaagt tggccttttt 65400 
           ggtaatagat gaaagtaaaa taattgaaag ggtctgttgc agttttggaa tatcttgaaa 65460 
           atatagtaga gtgaagcctt cttcccttaa ataaaagaca agttgctgat tgttttcttt 65520 
           ctagccagat aagaataatg ccttctttct cttgttagtc ttaacacctc acttgttact 65580 
           atgtgtcaga aaggcgagac accataaatg gagatactac tgatggaggt catctgacat 65640 
           ggggctggta ggcagtggga agactggtat ggacacaggt ggcttagggg ttggggaatg 65700 
           atatggaact aaggaaatga taattagcag aacccagtgt gcatgtgtgt gcattcgtgt 65760 
           gtccgtgtat gtgtgtactg tagcacaatg caagaaagaa aaaacaaggc agacttttca 65820 
           taatttcagg gataaataaa tcctttatca cttcatgtag aatattggct acttggaggt 65880 
           atatctaaac gtaaatatat aactatataa ctacatgcta attaaaaaca tacaaagaag 65940 
           aagtgcctaa agaattacaa cagaaagtgg catagtgatt attagagtta atataatata 66000 
           aataaggcca ggcatggtgg ctcatgccta taatcccagc acttttggag gtcaagttgc 66060 
           agggatcact tgaggacagg ggatagagac aagcctagcc aacatggtga aacccatctc 66120 
           tactaaaaat acagaaatta gctgggtgtg gtgatgggcg ctggtaatcc cagctactca 66180 
           agaaactgaa gcaggagaat tgcttgaacc cggaagctgg ggctgcagtg agccaagatc 66240 
           gcgcactgca ctccagactg ggtgacagag aaagacccgg tctcaaaaaa ttaaaaaata 66300 
           gtataaataa tatttcaaaa cacaagtctg ttaagataaa aggtacagag gaatggtgag 66360 
           atgacttttt tatttgtgtg ataagggact gttttctgtg attgtgagaa agaccaggag 66420 
           ttaagaaaaa gtggccatca ataaatcagc cacttatggg gaagaaccat aaaccactct 66480 
           cagatgaaat acaaatgcag tcatttatta atattattgg aatatttgta ttagtttttg 66540 
           gtatgtgctg ctagtgctgg tacattttag tagtcaatta atattttgtt aatcttaatt 66600 
           tctaactaaa ttccagagtg aaatggaaat aataatgaaa aaattttatt tacaaaacag 66660 
           attttgtttt tttctgttaa gaatgataca cagttgtcct tcagtagcca taggggattg 66720 
           gtttcaggac ctcccttggg tactaaaatc tgcagatgcc taagcccctg ttataaaatg 66780 
           gcttagtatt tgtatataac ctatgcacat cctctcatat actttcaatc aggggtcccc 66840 
           aacccccaggg ccatgaccag tactggtcca tagcctgtta ggctgttcga taccaggctg 66900 
           cacagcaaga gctgagctcc tcctcctgtc agctcagtgg tggcattaga ttgccatagg 66960 
           agcacgaacc ctattgtgaa ctgcacatgt gagggatcta ggttgtgcgc tccttatgag 67020 
           aatctaatga taaatgtaat gtgcttgaat catcccaaaa ccattcccct tcccctcacc 67080 
           atccctgtcc gtggaaacat ttcttccaga aaaccagtcc ctggtgccag aaaggttggg 67140 
           gactgctgct ttaaataatc tctagattac tgataatgcc caatacaatg taaattctat 67200 
           gtaaatagtt tttatactat attgtttaga gaataatgaa aagaaaaagt ctacatgttc 67260 
           agtttaagtg ttgataagtg tgtagagaaa agggaaccct tgtacattgt tggtggaaat 67320 
           atagattggt gcagtcatta tggacaatag tacggaggtt cctaaagaaa ttaaaattag 67380 
           aattacctaa gacccagcaa tccctcctct ggatgtaccc aaaggaaata aaatcatcac 67440 
           ctcataaaga tatctgcact gctatattca ttgcagcatt atttacagta gccaagatat 67500 
           ggaaaccacc taggtatgtg ttggtgcatg aatggataaa agaaactgtg gtatatgtat 67560 
           atacaatgga atattattca gccttaaaaa aggagaagac cctgtcattt gccacaacat 67620 
           gcatggacct ggaggatatt aagctgtggg aaataagtcc aacacacatc cacacacaaa 67680 
           attgcataat ctcacttata tgtggaatct aaaaagaaaa agttcaaata taaagttaga 67740 
           ataaaacagt ggttaccggc cggatgtggt agctcacgcc tgtaatccta gccctttggg 67800 
           aagccgaggt gggtgaatca cctgaggtca gaggttcaag accagcctga ccaacatggt 67860 
           gaaatcctgt ttctactaaa agtacaaaaa ttagccgggc atagtggcag gtgcctgtaa 67920 
           tcccagctac tcaggcagtt gagaaaggag aatcacttga actcaggagg cataggttgc 67980 
           agtgagccga gatggcgcca cttcactcca gcctgggcaa aagagcaaaa ctctgtctca 68040 
           aaataaaaaa acaaaaaaca cagtccacac actggttacc atgagtgagg tggcagggag 68100 
           gagattggga gatgtagatc taaggataca aagtagcaga tatgtaggag gaactaaaaa 68160 
           gctgacatgc aggatgacaa ctatagttag taatagtgta ttgtattcag gatttttgct 68220 
           aattgagtag attatagctg ctcttgccac aggggaaaaa gtgggtaact acgtgagata 68280 
           gacaatggat gtgttaattt ttgtcactat aataaccttt tcaccatata cattcatctt 68340 
           ataacagcat gttgtttact gtaaatatat acaataaaat ttatttttaa atatctgagt 68400 
           atgatttgat gatttgtgaa aatagagtga attataataa ttttaaatgt aagttaatgt 68460 
           tattagaaaa gaaacagaaa gaacatacca cacagaaagt ctgtctgaag gatctttgtt 68520 
           ttctccacca atacaagtgt tcattgattc agaggtggat tatgagatat gaccataaaa 68580 
           caaaaatttc aagggaaata tattttattc aatgaaaaat tctcaacaca actgttatat 68640 
           gccagtaaac actatatctt ttaaataaca ggtcatatct attatatta aaattcaagg 68700 
           agagactaca ttagagatgc tattagatca acttctaatt tcaaagattt ctaagatatg 68760 
           gaacagttac tccttataca aattaaaaaa gcaaatgctg aagaaattca gctacatgga 68820 
           tacaccatga ggtggaaaga tgctccataa ctcttagtta aactgcacta attacacata 68880 
           aaaggaaaat gtttcatttc actgtaattt ggaaaccaaa gaaagaaaag actgaatttt 68940 
           tacatactgt taaagagatt gcgtatctgt tctaagttta agacagaggc aaaatgtatt 69000 
           ttatcattt gtcctgcacc gtttagaaat aaaattcaac ttccttttaa ttttttttaa 69060 
           gaataaaaaa ctcagtctaa ggaaagtctt aaagttttca ttttaagtga tccactgttc 69120 
           tagaagttta atattttgtt taaaatgttt atgttctgta ttccaccaag tctagtttta 69180 
           aaacaaaaca aacaacaaca aaatacttct ctaacttgga gtttaaggtg aaagaaacca 69240 
           attacgtggt ttggaaatgt cacacttttc atctcttttt taaaaaaatt tttaattcag 69300 
           gacagaaatt gtatggattt agtgtaagtc ttgggatctc acaagtgtca gtatttcact 69360 
           ctcctccata tcttgatagc aataacttga aataggatct cagtagctca agcaatactg 69420 
           ggctctgaga gttggttaaa aattatttgg ctgagcgcct gttgctgagg gaagaactaa 69480 
           tctcgagcat atttttggag ccaaatacca aattgtttgt gcttagcaac acagcaccag 69540 
           gcttgccctt cagaatgatt ctagaccaaa tgccagaaat gctctggttc tgactacaga 69600 
           gttctattca caaatgacag gaggcaagag gtcctcctca ctttcagaag aaaggtcctt 69660 
           tgctttctta gtcaatggta ggaaaaccat tgtggttttc attgcattac ataattttta 69720 
           aggtgattac ttcaataaga agtgctctgt gtatatgtgtgtttatagac gcatttttta 69780 
           aacactggag aatttctgaa agtagtacaa accttgtaat gtcaagtaga tgtgggaaaa 69840 
           agggagttta caacattctc tcctgacatt gctctccttt ggcatctgca tttttaaaat 69900 
           gttaaaaatg tttaaaaacg tgtgcttaac acttaatttg gtgatagttg ctgttaccaa 69960 
           ggcaactctg taactccacc cagataaaaa taaatcttga agatgagttt ctgtgtctct 70020 
           gagcaaatat ttttgtgaat agtagaagca gagaaagtta aagatacctg agcttttgat 70080 
           ctttactagt tttatagata tgtttatagt tatacatttt tattcataca ttttagataa 70140 
           ataactttgt aaagcaattg attcttcttg taaaaatcaa gtatattctt aatagactga 70200 
           taaactttct ttttttgaga cagagtcttg ctctattgcc caggctggaa tacagtgcca 70260 
           tgatcttggc tcactgcaac ctacctctgc ctcctgggtt caagcaattc tcctgcctca 70320 
           gcctcttgag tagctgagat tacaggtgca tggtaccaca ccccactaat ttttgtattc 70380 
           ttagtagaga tggggttttg ccattttggc caggctctga gaaacttttt aaggtctctt 70440 
           ttgcagccag ctatttgtct accttatttc attcttaatc tcactagcca atattttttc 70500 
           tgtttaagtg ctttcagcaa atattaaatg cttgtgcctt cagtcttatc ctgtggaaac 70560 
           actggtaatg acaaaaacac atatttcaac ctaatataca atagaaacag aatgccagtt 70620 
           attcatggag gagaagaata gacttctgta tttaaaataa cattttgctc tgtgttttaa 70680 
           aatcattctt ccttcatcaa ttgtaagcat cttgactata atttatacac ctaaagataa 70740 
           ataattcagt agcaatgata actgaaaaca ggacacatac aatgaactag ctaaattacc 70800 
           atacattctc atccatttca aaaatagctc tgtacttttt tcagattttg ttagaagaat 70860 
           attcaataca aatttttatt caatgaacac ttcagatgtc aagattgtta cccacatgga 70920 
           caacagtaac ctaggtaaag attctgcagc caggcgtggt ggctcacacc tgtaatccca 70980 
           gcactttggg aggctgaggc gggcagatca tgaggtcagg agatcgagac tatcctggct 71040 
           aacatggtga aaccccatct ctactaaaaa tacaaaaaat tagccaggtg tggtgtcatg 71100 
           tgcttgtagt cccagctgct cgggaggcta aggcaggaga atcgcttgaa cccgggaggt 71160 
           ggaggttgcg gtgagccgag attgcaccac tgcactccag cctgggtgac agagcgagac 71220 
           tctgtctcaa aaaaaaaaaa aaaaaatttt atacctgggc tctgtgctca ccagcagaag 71280 
           gggtaacatg gcttcttagg acaaccttac ttgaccattt acttctttga cactaggggt 71340 
           attcttagat cagcaggtcc ttccctccac ttatgcacat gaggctcaca gagagtctgg 71400 
           gaggcaggga atttatgatt ggaaacagta tactttttat ctaagaaatt attaatgtca 71460 
           ctgcattcaa gtgattaaca ccatcaatat cttcaagact aaggggatta catgatgtgt 71520 
           aaaattagaa aactgtcatc tactagtggc taggcacttt aattatatta agcatgcaac 71580 
           aagagaactc ttcaaatgaa tccatctctc ctctgtatta tttccaaccc ttggatcccc 71640 
           atctgtttct gcagacaaca gctatgctgc tgaatgtctt aatggtttgc tgccccaact 71700 
           agcttcaaga tactgcaggt caagcatagc atcttactct tccctgcatc tccagcacct 71760 
           ctcagaatgt tggtcacata gaagatgttt gctgaggagt tgaataagaa tatgtacaag 71820 
           ggacacaatt agcattgttt aaaaaagatg taacaagata gggtaaagga aagctttgga 71880 
           ggataaatct ttagaacaat caataatatc ttctcctctg ttggttagtt gcccttcaat 71940 
           ctcagccact gaatcaaata caacataatt actattctga tatgttcttg aatcgaatat 72000 
           ccaataataa gatattcgga tgcatagcca tgtctaatat caaagcccat gcttttcgct 72060 
           attattgtac tccatacatt agcttccaaa tttatttgca atccaaatat taaaagcaag 72120 
           tcataagctt agtatcgcca atgtgatact aagtatccac ttactaaact ttattttcaa 72180 
           aatgtggttt tatctcagtt taatgaacac ggcatgtttt aatttacact ttcatattat 72240 
           atagtaaggg cgtggttaca gatatgttaa tttcctgtgc tgcttcacaa tgatggaaca 72300 
           taatagcaaa tgaaactgtt aatttgcaga tacccatagg cctttggtgt ctgaatagaa 72360 
           ataaacacac ctacaactga gagaggaagc atgtgaagca ttccagtgaa cagaggccat 72420 
           ttattcagtc acagacacag gagaaaaaca acaattaaaa aaaaatctct gatgaaaagt 72480 
           tcataaaaag ttcactcagt ttaagcatat gtcctataac tacttaaaat agagttcttc 72540 
           ttaaatatca ttctttgctg tttttagatt tcttctgcct gtatcaaatt aatagaacac 72600 
           agcatacttt taatttgctc tggtttctta gtggggcatt tattaaacac attaaaacaa 72660 
           tagtctcagg gttttactgc tgatgttaaa gttctgcttt cctacttacc aactgtgtca 72720 
           tcttaaggca catactttgc ctctctctca aatctcccaa atggagaatg ataagaatac 72780 
           gtacctcaat taaagaagct ataacaagta gaatgtttgg aaaagtgccg ggtacaccat 72840 
           aagcccacta tgagtattgg attgtattac ctctgaaagc tgcagaatgg aattctcaaa 72900 
           gttatatgtc cctaaaatcc tcttaagtga cagaaatgga gaaattagca gtctgtctaa 72960 
           gagagctttt ctagagtctg ggcatatgtt tttaggacaa gacagttcag cttcagctta 73020 
           aaatgagaga gcacgtctgt gtccttactc ctgggtgcca ggtttcttgt ccccatctta 73080 
           agacaaataa ttttggtgga gaagaggcag tctctttgat ttcgctctaa aaaccttttc 73140 
           tggaggaggt agacactctc cacccccgtt ttgagactca tgcagctgag gatgactggc 73200 
           tgagtacaag caattgttcc ttctaagcag tttcaattct tataacttgt ggagatattc 73260 
           ttaagtccag gggattttgt gtatggtgga tttttattac aaagtcctgt acttcatagg 73320 
           aacaaaataa ttcaaagtca ggaaccagat caaagccaca actcagatat ggcaccttga 73380 
           gaagttcatt tgtatttcac ttgcataaaa accctcacca ctgctatctg attttcacaa 73440 
           atcattcaac agctatccat gaagcaccca ctgtgtgtct ggtctctgtg tcagtccctg 73500 
           gcttcatgtg tctttccttc tgtaccctga ctccccaact catgaacaca tgaagtaaaa 73560 
           aaatgaaaat ctttttctga cctctcttca aaatcacttt tttcaaaaca aacacctctc 73620 
           acctgctcat cctccagcca gtaaatcaca ggggcctaga aatgtcactt acaaatattt 73680 
           tctgattctg tccctccctt caagcttgcc aacattatca cagtttaggg cctgctcatc 73740 
           tttcccccaa tctccaatta gatctctcca caatgcaatt ctgcacattc cctgttacaa 73800 
           cccttcaatt atttcccagc ccatccaaaa taaaatctaa gcctcttact aacacattca 73860 
           ggaactctgt ggcctacggt tttctacaga ctaattttcc agcagttgac ttccagtgca 73920 
           agtgaaaacc tagtgtcatg cctgcatgat agataaattt gaagctgaag agcccaaatg 73980 
           tatagaccat gccatgaaag gtttatagtc atgacacagt ggccctatag tacagtgctt 74040 
           gaagctggct ctctactgtc agacagacca cttgccagcc atgagacctg gggcaaaatg 74100 
           ccttaatttt tatgtgcctc aagttctcat gtgagatgag aataaaaatt accccctattt 74160 
           cataagattt gataaagtgt ttagcataat acctcataac aattgcaatt cagtggtggt 74220 
           tattattata aagaaaagat gattaacttt atcttaatgt ttaacttgtt ctgatagtta 74280 
           ttgatctata gctttgatat ggaggtttga gaatgacctg gaaagaattg gccacaatga 74340 
           ttgaagatag tgatacaaga ataaaagatg actgcaaaat gtaaacctgc aataacagaa 74400 
           agaatgaagt cactggtctc atgggaactg atatgggaga aaaaaacaga tcaaaaggct 74460 
           attcatgttt tgggcctctt tgtcaaaatg gaaatgagaa actggggaat aaaaattaaa 74520 
           gcaattctag catctggttt taacataatt cttatcccta aaaagaatct ataagaaact 74580 
           cccaaaatga caggcagccg tgggtagcat tgcatttcaa gtaatctttt aattgttaaa 74640 
           atttaagttt ccaacatgaa cataaaattt tcaacctaaa agaaatgagt tccaaatctg 74700 
           agacaagtga aaaaggataa agcctactag ggggtaaatt ccatctcttt agagatctag 74760 
           tacccaattt agcaatgtcc aatcaagcct ttaactacta catttgaaca cctcatcatt 74820 
           tcaaaatgtt acttaatgat gccaattaac tgtacaatgt ctctgcatag cacatagccc 74880 
           taaaatgatt tgtgcaatgt tactgtcagt aaaactgaac tacagggaat gctcatattc 74940 
           tatgtcatta tatacagaaa tgcaatatca ataaagtgat atctgttggt attagaaaaa 75000 
           agtgaaaatt ttcatatctt tctattttct tttttcctca atgggatgct cttgttaaag 75060 
           atagctctgc atagtaaggt ttgtataaac attatttagc taaagttaaa aggggtaaca 75120 
           tactggttct agcacagata ttaaaacaaa ttagtttgta ggtagggcag caatcaatta 75180 
           tattactaac catagctttg gtccttttat cctttcccat ttgattttac acagtgggat 75240 
           gttaaaggtt gaatgtcttt ggtatctata aacttaattg aaagctgtta tttgtttgtt 75300 
           taagtctgtt gatttttata atcataattt tactcctata gatttcttgt aggagtacta 75360 
           tatgaattta tgttgcactg aattttgtta tgttatacaa attaataggc ttttatttat 75420 
           ggaaagctac tattgatctg tcatttctta aaaaattact aaaaagtgtt aaaactttaa 75480 
           atgttggaga gtttatattt taaaagttac atgctagaaa aacatgatgt ctgagtatat 75540 
           tagaagttat agataattca tctgtcaact ataaaactct ccaacactgc ctttctttaa 75600 
           tgaataatat gaaatttagc agtgaaaatg tgacaatgta caatcctaaa taaatcaaca 75660 
           aatttagaga tgtacctcta aaaccattgt aaattcaaca gtgtaatttt ccattggact 75720 
           ttcacttatt cattcattaa acaaatgttt gtgagtgcct gcaatgtatg agacattgta 75780 
           ctgaagctag gcagtgtgag ttatcatatg ggattatcct ttaaatactt ctgagggcaa 75840 
           aaaaaaaaaa aaaaagaaga gaaaaggtgt gaggaaagat aaagggttaa ttcattaaaa 75900 
           aataacactt gaggactgtt ttctttgcaa ggcataaagt tatcaccctt tcaaacagta 75960 
           gatatttcac atttaggatg cgagactcca gttccaacaa agctcattgc acagctgcta 76020 
           ccctgattaa actgctacat gaactctgag caatgtagca tggtagccgc atgcttctgc 76080 
           ttgcatgatg gttaattcct tccattctca ttagtgattt tctgagcttt gaaattctga 76140 
           tggtacctag gatataaagc atatttatct aactgaaaaa cagataatta gatgtaacat 76200 
           aaaatatgaa tggctttgtc actttatgt agcagagaat gaatgtggga taaattaaag 76260 
           ctgatgctag aacatatgcc tattttttag ctggaaaatt tcaagattta tgtactttgg 76320 
           gcttgagaaa gaaatggagt ttatttttta tgcactgaca tctctttttttttttttttg 76380 
           gaagagctct cttaggaatg aatggtatgt aaatacagta ggaatgtaat tatagatttt 76440 
           cctgacccag ttcctaaata atagatatca tttcagaagt gccccaatac ctgacctttt 76500 
           gctccaagcc atatcaaagc acacatctag tctacttttc actctcattc ctagccacta 76560 
           tgacaatact attcagataa aacttctagt cctctactta tgtgactcat accaacttga 76620 
           ccttacgata gtgactgggg gtgcatatct aggttcatgc tgtttgtcca ttattatggt 76680 
           tttgtgagaa aaggcaaaat ttctaggtaa agtgttatga ggacgaataa tccaccaggc 76740 
           aaccaactga ccctttcatttgccatcttg tcacttcaaa cagctctcca gaacctgcag 76800 
           ccagcacaga ccaaagtcag gtttgtctcc tcttctgttg atgaacaaag gttgattcca 76860 
           tatcgtggct attgtgaata gtggcagtaa acatggcagt attgtatgaa aatatcacag 76920 
           atagccctta aatatgtgca actatgatga tctatcaaaa ttaaaaatta aaatttattt 76980 
           ttaaaagttc agttagaaag cttgtagttc ctggcaaact actacctttc tcggcaaaag 77040 
           aatttgatat ctcttaaata ttttctgcct aatgctgata gattgtattt acatattcca 77100 
           ttaatgcaat aaataaaatt acaccaaaac atcagcatta tttattcca ggggcatctc 77160 
           tcaaaataaa ttcctccaaa attcacaaaa ccaaaaccaa tgtgaaattg tactcaggga 77220 
           tgcaaatgta gcccagtgaa gcatttgccc acttgtttgg tattattgaa gcacaattag 77280 
           aaaaatgtgc aatgtatgcc caaaaattct ataataaggg ccaggcgcgg tggctcacac 77340 
           ctgtaatctc agcattttgg gaggccaagg tgggcaaatc atgaggtcag gagatcgaga 77400 
           ccatcctagc taacaccatg aaacccagtc tttactaaaa atacaaaaaa ttggcccaga 77460 
           cgtggtggcg ggatcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggcatg 77520 
           aacccaggag gcagagtttg cactgagcct actctccagc ctgaacgaca gagcgagacc 77580 
           ccatctcaaa aaaaaaaacc ataataagaa ctttttaata tactatatta taatgtaaaa 77640 
           agactagatg tcaaacaaat taggtgatgg gaaggaattg agggagaatt ttagactaag 77700 
           caattgagca gcacctgttt ttcaccacaa atctgttaca tgtattgctc aattgtgctg 77760 
           aatccatatt gggtcctggt ggctatgtaa tagtctcttt cttggataaa tgtttgtcct 77820 
           ctcttatggt ttactaatgg tgtacagaac agcattgaat agtggttat tcctatgact 77880 
           tcctagatat ctctctcata atcctgaatg ttttaaagat cattcttaga tagagtacag 77940 
           ctagacacga accatagtgg aaatcaggta gacaaaattt aaaaggagtc ttaattgaag 78000 
           gtcattttat tgtcctcagt attaatctta cttaaaacaa acctgtcact gagcagaact 78060 
           caaaacacca gagccctttg ccaaatgtga ttttttacaa caggagcgct ggcagttgag 78120 
           aggagtattc tgtcacactt gagagaattc gagtccctga agattatat gaatgcttag 78180 
           ctattatcga accatctctt cacagatgac ttagtaaatg tctgcctttg catcagataa 78240 
           tggcttacaa gttaatctcc tcttgctccc tgttacacac atatacacct tcttcctaaa 78300 
           cagctcataa ggtgaaagaa agactcagat ttctgactat gtaattgata atatcacacg 78360 
           gactgcctgc tcatcatctg ctagtcacat tggcagagtt gacagttttg gagacactga 78420 
           agacagtgca tatattagga aataagcagt ttcctgatat aaattttctt gtagtttata 78480 
           aattacatatag catttattat tccctcatat tttataacat ttaataatag aactgacaca 78540 
           tatattcatt ttaaactcaa ttgtgtataa taactatcat agcaaccctt cagtgcctaa 78600 
           atatcaaatc ttccattcct cccatgaaca tcttgaatat ataggtactg tggttagctc 78660 
           caacaagctt ttggttagaa ttcattgcac tgatacatag aattgtttt aaaggcaatt 78720 
           tcaaatcaaa gctgtcagct gtgaatcaag cacaccttaa aaagtgacac atttgtcact 78780 
           agattccagc ctctcaaatt actgacacgc atccttttta tgtaaagatg aattgttct 78840 
           ttcctgatat attgcattcc tcatgaattt cttatagtca tagaattttt ataaaccatt 78900 
           tcagaatcgc tgaaataaac atcaatattt ttaacttttt cattctgtca aaaatattgt 78960 
           atgcagagat attgctgtaa gtgtgtatac ctgtgcttaa gagactaggg ctgaagagaa 79020 
           gtaatcaacc gaaccactgg tgtaaatgtg cgtcacattt ttagtgacta gaaattgaaa 79080 
           taattccaac aaatttatgt gctttgggct tgagaattca gactgcctta ggctaagata 79140 
           aaaatctttt cctggtacta tataccttct tttattgaat gactacctgg ctctttctat 79200 
           tatatatgca gattttgtac ctctggtcat ctttgtaaat ggtgcctaaa agatatttga 79260 
           agaataagtg accagcaata agaacaaatg tctatacaaa agcacccttt agttggatgt 79320 
           aattcactac tttgagttgt taataacctc taaggatgac agtagctatt agttgaataa 79380 
           accattatgt ctattattag aacactagat agtttataag tccaaacaat gcataaaata 79440 
           cctatctcat gttaccattg tttaggttac cagataattg ttctgtccaa ttatccact 79500 
           taattttttg cttgcccatt agctaaatgg caagataaaa tttgtcaaac gggggggaat 79560 
           gtattgaaaa tgctagacaa ctacacttaa aatgaaaaca ggccaggcgc ggtggctcag 79620 
           gcctgtaatc ccagcacttt gggaggccaa ggcgggtgga tcacctgagg tcgggagttc 79680 
           aagaccagct tgaccaacat ggagaaactc catctctact aaaaatacaa aattagccgg 79740 
           gcatggtggc acatacctgt aatcccaact actggggagg ctgaggcaga agaatcgttt 79800 
           gaacccagga ggcggtggtt gcagtgagcc gagattgtgc cactgtattc tagcctaggc 79860 
           aacatgagcg aaactccatc tcaaaaaaaaaaaaaaaaag aaagaaaaga aaacaaatgc 79920 
           ataatttgca aatattattt ttatattgta tgttatctag ggcttctaaa tgcattcttc 79980 
           ttataagcct aggtttgcaa taacattcat ttagaattga gtaattttaa atataatatt 80040 
           ttataaaata aaatataata atttctctta attctttgaa aatattaaat taaaaggggg 80100 
           ttgcaaactc tgcattccac atttccatcc caacatttaa ttttagcaat tttgtagtct 80160 
           gcctaaaatg caatccatca tttactgttt agaaaatagg gaatgtacac aaaggccttt 80220 
           cagctttccc tgaactccat aaaaatcttt ttgcttcttt actgcccccc tttgtcagga 80280 
           gttctgagga actgtttttt atcttaagtc tcacaaagca tttaggagaa tattaaact 80340 
           taaattcttt taaaacttat gttcaggaca aagtaacatt gtatgcattg gtgtcatatg 80400 
           tattaaatt ttgaaatttt taatactggc aaaatgaggt ttcaatttta atataaatta 80460 
           tttaacaatc ttaaatcatt aaatatatta cttaatatat ttaatatatc taaacagtca 80520 
           caattttccc atactaataa tcataaaaaa tcttacccaa tggtcatata gatatactta 80580 
           atggagtttt ggggggggtat ttttgtatat taaaaaattc atatatttgc cttacttaga 80640 
           agaactgatt aaatgaaagt ataatattaa caaacatatt gttattttat atttgcattt 80700 
           gtgataatta tatttgaaac gttcaagatt ttccaatgaa tttcttttgc atttgcgtat 80760 
           ttgtgccttt ttattataaa aataggtggc tttttagttc cactgcataa gtttcaacat 80820 
           aggtctacaa atagtgcatc tttttgaagt taatcattat aatcacaaat tgaagttgcc 80880 
           tgagctccaa ttggagtcta aatggatgac tgaatcttat tattcgaaac ccactgttgc 80940 
           tacacaatat ggccacacaa gagagtacac aagacccgtc tgattcagcc tcagtgccat 81000 
           aaatatttta atggtttcgt tggaatctgg aaatggagct caccacagga gatgcttctt 81060 
           cctttgactc tcattattat ttcctttaca aattaattaa taaaaactta gatgctaaat 81120 
           tagcacttga tgaaaactta tatagccttg aattttgat tctgtgagtg aataaaaata 81180 
           cttggagaaa taaaaatcct aatcatgttc aggaataccc acaaggtaac aagtacattt 81240 
           ttaaacttta aaaacattta ttaattcatga taaaacatgt tgtgtgattt aaatataaat 81300 
           ttttattatt tgctttaact tatttccgga ttaaaaagta aatgtttacc tagctgttct 81360 
           aaatggtaat cctcatgatt aaaacagcaa tttgtcatat ttcagttaca aatgatcttt 81420 
           tattattagt tatagaacat aagtttcttc attgactgag gcgatgtttc aagtagataa 81480 
           atctgttaaa aaaattgtgg tcatattctg ttaaattctc ataccaggca atttgtttga 81540 
           tattcaggaa aaacctagcc actgaccaaa aactctacct gccttctcag ttgtatcctc 81600 
           ttggacttaa aggggactgg gaaagttata agatggttca tgatagtcca tcaacatccc 81660 
           aagaacaaaa acagatgttg tactgacagc atcatatgat catatgcatg taagagcaca 81720 
           ttcatattgc caaatcagtt ggaatttttc acggttgaaa gttaaatgaa atgcttagat 81780 
           gtatgagtca tcggagttaa agacaattac agccagattt atggctgtgc taaaataaag 81840 
           ctagttagaa aacagaccaa attccatgac gataccaagt ctgactaatg attcacctta 81900 
           aatttcggag caacatttat cctcacttgtttgtttattt gacaatgtgc ccttatccat 81960 
           taagtaacta ggaggaaggg aaaagcacta cgtgggtgag tgacaagaca ctgacactga 82020 
           tttgtgactt tggataattc ctggatgctg ttatctgttt tggcatagag atggatctgt 82080 
           aactgctaat aattgccgac tgtgaccatc ccagaggcca tttacttaac ccaggtattt 82140 
           cagacctgac agcccgagga taaacacgat ttccctccat cactaacttc atctgcaggg 82200 
           cctaagcctc cttcacagtc tctccagtga tttattggca tctccaaggg tatctcacat 82260 
           gtgctgaaga acaaatctgc tcactttcat ctgcttggtt ttcccttttg aaatctgctg 82320 
           ctttaaaatt actaagggag gaatcatgcc tgctgctacc cttgccagtg accttgcagt 82380 
           ttgtgccctg attgttccaa ttaccacaat caaaacagaa gcgtttgcag ttactgcagt 82440 
           gctctctctg tggatgtcag gtctgactca gagagccagg ctggggaaca gccatttcca 82500 
           ctcttgtacc tctgcaaaag gacttccatg ttccgtaaac agactcccac ctctcatttt 82560 
           ccccccaagc aaagcatcat aaattagaga gcatgtaacg ggaaagaaaa tccattagcc 82620 
           attgggttc agtcagacaa gccagctcat ggaaagttta tacaggaagg tcacatttca 82680 
           attgagatca ggagggtgaa agggtccagc tgtgtgatga gagagagaat gttcgggaat 82740 
           gtggaacaga ggtatccaag gcagaacaaa ctcgtatatg aaggctttaa gggtgtgcaa 82800 
           atctagcata ttttatgaca taaaagagtc ctgattagct agaatatgat gaatgtgaga 82860 
           agaggtgaag gctggagata ggaaaaatta ttccagatct tataagctat agtaagaaat 82920 
           ttgcatatta tatatagact tgtgggaagc cattggattt tgtaagaagg agattaacat 82980 
           tatcttattt atgttatttg tgatttataa ccccaaatgt gccagataca aacaaaccaa 83040 
           aaataataat aataataata agaagaagaa caacaacagc aatggaactg tggtgatggt 83100 
           tttggtcaca aaatgcatat atatctattt ttcacaatgc aaaaatattt cattatttca 83160 
           aattttaaca taaatgtggg tatgcatgag cttacaaatc ttgaagttta ttggggaata 83220 
           ttggtgagca tggtttttat tgcatggtca caacttacta atgggaaaca tctgaatacc 83280 
           tattgagtta atgcatgcac atttttattt tcctggaata ctgagaaaaa ggttgctaca 83340 
           taatgtcttg atagcttcta agtcatggct caaaagtgaa tgtggaatct gctaatcgga 83400 
           atggactcag attcagccaa gttctcaaaa aatttgctt tcatagatgt cttcaagaaa 83460 
           caaggagtct tgaatttaaa ttgtgaagtg tctatcttag aatagagaga tttaaaatct 83520 
           gactgtattt tgtttaaaaa agcctatata actgtattat ataaaattat ttatactaca 83580 
           gttaaaaaaa gaatcccatc ctatttgtgc ctaaataagt gcctgcttgt agcatgaaaa 83640 
           ctatttgttg agggtcctta gatcctcaga gcatgctgtg aaagtaggta caattgttct 83700 
           ttctatataa gcctcttaag ataacagata attgccagaa atacagcaca cagtacaaaa 83760 
           ttaccttgtt ttacttttgc cacaaaaaac aatttctttt ggctttgagc aataaagtcc 83820 
           aatgatttttttcctttcaa aatatcttcc tccctctcca taagttttat atttattcac 83880 
           gaaggaatat tccaatatcg gatgtttttg tctgtgtctc ttcctggaac aaatgttaat 83940 
           taatctcttt gggtttgtat gtcaagtgga ggggtgggga ttggggacag gtgatagttg 84000 
           tctagggagt taacttcatc tctataggag agtggataga cgctgtatac gaaaagctct 84060 
           tgaaaaggga aatacagcag ccacttcctc agggcttcca tggtggtcag actccttgat 84120 
           tgctttagat taactctggc ttttgtcctt cggaggccac cagattgggt ggatagacat 84180 
           tgtccttgct gttcttttga cctacctact tgtactttag gggaaaaaaa tgcctgtaat 84240 
           aggttaaatg ctttctcaaa gatcaccaaa gtatataaca catggcaaat agacagagaa 84300 
           atgagacagt ataatcagta taatttataa aagtacctta cagcaggatc ccatgggata 84360 
           tgggtttttt ttaaaaaaaa tctacctaat cttttcattg aactcctatt caggattcat 84420 
           tatattgaat atggctcaga gacctggaaa attgtttcca cctttttaat ttattcacca 84480 
           tcatttatgg aagttttcaa ggacgtttac ttacctacct cagttaacag attgtactac 84540 
           ttgggaagtc tataaatatg agcttaaagc attttctgag ttttaaaata atttagattg 84600 
           tgtagaatgt taaaactaaa agaggaaaaa attattcagt tcctcagttg aacctagcaa 84660 
           tttatctttt cacagtgtgc tcaagtatag tttttgaaaa gtaaagaaga tggtttttat 84720 
           acaaacataa aacacatttca aagattttat tcaactaatt aattagtagt ggagccaata 84780 
           agctggtaag actggtttaa aggaatatct gaggaataaa gatttataga aacagtcaaa 84840 
           gaaattctaa agagaattga ctaaagata taaatctagt aaatatttga ttaataatag 84900 
           cagtaaccta tggaattatg ttttctactg agcataaatg agcatgaatc tctttgggtt 84960 
           tgtatgtcaa gtggaagggt ggggattggg gacaagtgat agttgtcaag ggagttaact 85020 
           tcatctctat aggagagtgg atagatgctg tataagaaaa gctcttgaaa agggaaataa 85080 
           agcagccact gcacatctgc acatataacc tgtagatctg ggggctctaa taaaaaagtt 85140 
           aatggcaatg tcaaaatctg gtgttttatc ttagataact tcatagtcat tgattgagcc 85200 
           ccttaaaaat aacatttaaa ggacatgtag tcattctgtt tctttattgc caagttttca 85260 
           gcaatttttc tcatgagaat gagtgctaag aaacttttgg tggagcgtgg tggctcaagc 85320 
           ctgcagtctt gcactttggg acgccaaggc tggccaatta cttgagatca gtagtttgag 85380 
           accaccctgg ccaacatggt gaaaccttgt ctctactaaa aatacaaaaa aaaaaaaaag 85440 
           tgggatgtgg tggcatgcgc ctgtaatcct ggctactctg gaggctgagg cacgagagtc 85500 
           acttgaaccc gggaggcaga ggttgcagtg agccgagatc ctgccactgc actccagcct 85560 
           gggctacaga gggagactcc atctcaaaca aacaaacaaa caaaaaagaa acttttaaaa 85620 
           tataacaata gagacattac ataggcccac aaaaccacct ccaaaaaagc attctatcac 85680 
           ctgcaagaaa gcatatatat atatctgctt ttgtgtatat atatatatat atatatatct 85740 
           gcttttgtgt atatatatat acacacacac acacacatat gtgtgatatc agcatgtgta 85800 
           tttacacata tattttgtgc atgtatattt ttaactaaaa atgtgctagg agttagatat 85860 
           gaactgattt tggaggaggt gatatgctgt agagagagag aatgggagaa tagcagtatt 85920 
           ataatctctc tccatgtat tcagtttttt tctttgtctg aatttttaat agaagtcagc 85980 
           cagaagatgt tagtttctgg gaaatgtgtt gagatttaca gtcaaatcca gagagaacta 86040 
           gaggcttatg agtaaataag taaaggttat gcagagaaag tattcttttt cctgtgtaaa 86100 
           cttgaatatt ggccaggcgc ggtggacacc tgtaatccag cactttggga ggccaaggcg 86160 
           ggtggatcga ctgaggtcag gagttcatga ccagcctgtc caacatggtg aaacccattc 86220 
           tctaccaaaa atacaaaaat tagtgggtgt ggtggcagga tcctgtaatc ccagctacta 86280 
           cggaggctga ggcaggagaa ttgctttaac ctaggaggcg gaggttgcag tgagctgaga 86340 
           cagcgccatt gcactatagc tacggcgata agagtgagac ttcatctaaaaaaaaaaaag 86400 
           aaaagaaaac cttgaatatt tcttgtactt gtgttcaaat catacagtta tgaaagttta 86460 
           cccctagctg ttacacttaa aatgtacttc tgaaatatac agagagatga tacagactat 86520 
           taatgagttc cactaaactt ttaatggttt agaaaataca aatattttct tatttttctg 86580 
           gaattccagc cattaatgta aaacattggt ttcaacataa ataacacact ggcatgcaca 86640 
           tatgcctaag catgggcccc cacacataca gacattctga aagaccactt tttaaaaata 86700 
           ttcagtaccg tatattgtgc attccttctt tatccacata cttaagctgc tgcaagcatc 86760 
           ccattgataa caccagtaat aaaagatggg accatcagta atgagatttg aaagcccctt 86820 
           ttgcaagaaa gtaaggacta gaaggtggaa atcactctgt cttagagtca tatggattgg 86880 
           ggctttgcta gaagtgtgtg ctctcaggga aagctgcctt tttattttct ccagagaaaa 86940 
           gcctttttgt cagtaaaaga agatgtatca tccaatgcat atgtaaaatt ctaaacagca 87000 
           gataaaacaa cattcactat taatctctgc aaaagaagat atattgaaaa aatcctcaag 87060 
           tgtccctctt tgggtttctt tgttatatat taaagcagtt atctttagat gcatgagaat 87120 
           cacctgaaga ccttattttt aaaattcaga ttcctgtcag ttcactccca aagattccga 87180 
           ttcagtagtt aagagacaaa gcctaggaat gtgaatttac aatcaacacc tcaggtgata 87240 
           gccatgcatg ttcttaatgc tctactacta tctatgcata aaaggaagat aaagttttaa 87300 
           aaacttgaaa tgtggtataa cagtttagta ttgaataata tacattttta cttattgtaa 87360 
           caaattatga tatctacttg gggcaacagt atcttttatt ttggatctga atcctaattt 87420 
           tggctaggta tcactgaggg attcttagtc taaaacaatt aaatggagtt agtggttttt 87480 
           tttagtaact cttgattttc tgtttttttc cattggcatc ttacaaaatt tattcattca 87540 
           tttttccctt tttcacttgg cattatttgt tagacagtgg acaaaagaac tatagaaagt 87600 
           agagaagcat gtgatgttgt cctgctctta gattctcgca actcaggaga ggacattcgc 87660 
           ttacaccaat catctcaaaa catggcagtt tatgctgaac tcagtccaat gggagagcat 87720 
           ttgactgagc acataggggag agaagttagc tctgttgaag gataatcaac gaagaattct 87780 
           taggaaaggt acagtcattc attgaatatt tgctcggcac ttactaggtg catatgtgca 87840 
           ctaagatcta aggatgggct gatgaagaac ccaggtccct tttcttctag tggacatgca 87900 
           gactggccta aaaaaaaaaa ggtaactgga aaatggataa ggaaactgag tcactcggtt 87960 
           tattattat cactcggttt atttgctttt gtttgtattt tcattttgacacagcacagt 88020 
           gtcatcttaa cgcatcctcc aaagtgaagg atggggtgga taacacttta gttggcattt 88080 
           ctgtagccag gagccaggat ctttctccca taattgcatt aacctgggaa ggcaccctct 88140 
           aggtagattt gtatagcacc ctggttaatc aattatcagt ttacttcttg tctcactaag 88200 
           ctttaacacc ttacatttat gaagcagtgt aaatataact ttagcatctt gatcacagca 88260 
           agcacctgat ttgtattttt ttattagctc aagtgaaatc agatcagaga agtacattac 88320 
           aggtcataaa atatgtgcaa atttcataat gacctccttt taaaatgtgc aaaaataaga 88380 
           ttgttaaggc acattccaga gccttggggg gtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt88440 
           gcgtgtgtgtgtgtgcttgt cttttgagaa tatctgtata tcagaaaatt tggctgagaa 88500 
           gcaatcttct tcttagtggt tctttttctc ttttgaaaat aaagtactaa aaatacttaa 88560 
           agatgcagaa cagcaacctg ttcccagtga gactctcgtt taattaatgt ggtgatctat 88620 
           atagagaaaa gggacaattg caaaagtccc tcaataatta tctaaccaca gtctttaggt 88680 
           aattacagca gaaagatttt caagacacaa aacaccctgg aaaatttgac ctcttatttt 88740 
           gattcaggcc tttcatttct taaatatttt ctttaatgtt gatgtttatg cttgacaagg 88800 
           tcagcctaat gccagatgaa tccctggaac tcaaaacatt gctgaattca cagttgaagg 88860 
           attttaatat aatataccag cttttaaaaa tcctacagtg agaataacag gactgaataa 88920 
           aaaaattaag aaatgctcag gtagaaataa atagagaaat ttagaaaaaaaataaaacgt 88980 
           attcaaaata agtattaagc attggcaaag aaaaaatagt agcagacaat tacatgttcc 89040 
           atttgtaaag atgattatta attagtggtc ttgcaaaaca ttggagaaaa tttgctgaac 89100 
           catcacattc ataaatatta aaaccaccca ttagtgaaaa tctttttact aaacttcaca 89160 
           actgatagtc aaataatgtt cagtttttct ccattgcaat aaaaaataaa ggcttttgcc 89220 
           ttcagatcag tctctgggcc ttattaattc agtcagccag aagccacatg gaaatatttt 89280 
           gttttgttaa aagccagctt gccctcatga tcttttaaaa tcttttaaaa atcttccatc 89340 
           agccctctcc ctgacttgaa ttatggcagt gctttctaaa ctggtaaact caatctcctt 89400 
           ggtgtgcctc aagatagagt acataaaccc tccttagaaa ttgagctctc aattctaaat 89460 
           tgcactctcc atgagagcaa gcaagaatgc tttgctttgt attaagtggt cacaatatta 89520 
           aatataacca tagacagcac tgtattttct aaacacctta ttttctttta atgactgaca 89580 
           taaattagat cataagtata caaatgcata tctgttgtat ttttcagcac catgtgtttt 89640 
           tttttcttttttctgagtta ttttcctgct ttcggcagcc ttttctctca ggtgccttgt 89700 
           gatccacagt ggtgtgtgtt cacactaacc aaagcaatag tcttacctgc cagaaatagc 89760 
           tgtgacattt aaagagaggt ccagggggaag gcacagtgct taacatccaa gtctgaagag 89820 
           ctaatagtga aattggggca tcagctacag agagatttag gggaagtaac aggcaggtta 89880 
           aatattttat ggaaatgatt tctgttctgt atatgattgc aattaacaca tgtcaatctg 89940 
           tttcattaat ttgttaactc atctattatg ctatgccatg aagaaaataa aattggagtt 90000 
           ctttattttt ttgagatgga gtctcactct cttgcccagg ctggagtgca gtggcaggat 90060 
           ctcagctcac tgcaatctcc accacccagg ttcaagcgat tcttctgcct cagccacctg 90120 
           agtaactggg actacaggtg cgtgcaacca tgcctggcta atttttgtat ttttagtaga 90180 
           gatggggttt caccatgtgg gccaggctgg tcccaaactc ctgacctcaa gtgatccgcc 90240 
           tgtcttggcc tcccaaggtg ctgggattac aggcgtgagc caccgcgccc cgccacaaaa 90300 
           ctgaagttct aagcttcagt ttagatgctc actaaatgct tgttttgcaa tacctgactg 90360 
           taactggcag gaatatgttt tgaaagtcct cattttccag gtatgcagat gaaatatagg 90420 
           ggcattatct actatgtcaa attataatga tttatcagtg gcacatgaaa gtcgcctcac 90480 
           atttcttaat cagtgatata ccattatgtc atgccacctt ttaatgtaat atgtttacat 90540 
           ctttctttag atgtaagcat tcatttagtt catcacggtg gctttcacac ttactccaag 90600 
           aacgctatga gttcctttga tgtgctcaag tctcctgccc cagggagaaa gggagtggtg 90660 
           agcaggaatc gctttaatct atttacacag atattttctt ttccattatttttaaaggaa 90720 
           ttttttttaa cttaatgagt atgcagtgac ggtggtgatg atgatgatac taaggtttaa 90780 
           atgattagat agtcaaatct gggctggaat tgtaatactg ttttgacttt taatcttaga 90840 
           gaagctccag tctgcttatt ttctgggcat aaacacatga gaacaataac acagttctgt 90900 
           tatctgaatg ttgttatatt ttgtttgaaa cattcagtga ctttcaaata ttgtatttgc 90960 
           ctaagaaaat tcaacagagt cagacattct cttccaggtt aaatttggtg agtctgctag 91020 
           gaaaataaat tttgtgcact ggtcattctg atctagtgga cgttctaata aaagcacctt 91080 
           tgtgctgcct acgtcttcac tttaaagata agatacctgg gtactcgaca ccaaattata 91140 
           gtttgagatc tcaaaaatgg gatagggaaa ccacagctca aaaacaaaaa tactagcact 91200 
           ggaaaagata gaactagtga agatgaatca ttctctagac tttaaattca gagatatcaa 91260 
           aattaagaaa aagtaggagg aataaaaaaa gagggtaagc aaaacaatat aagtttgtat 91320 
           agcaagagggg tataaagcaa atacaatatt tttcagaaaa attaaataaa aatagattta 91380 
           cataacattg tttttaatct caaagatcaa atttcaattt tcatctcatt ttaaaaccca 91440 
           tatgcacagt ctcctttata tacatcagtt gggtgtcaaa gtgacttttt tcttgtttcc 91500 
           aaatacagtt atttttaaaa tttaattgta tgatttagga atttgaaagc aagccagttt 91560 
           gcacacacat atgttattat atgtgtgctt tagacttggt ttttagttaa tgtaacatga 91620 
           cagggccacc tgagttattt gtttacaaac tagctggaaa gccaccctgg aggagaaacc 91680 
           tggcaacaaa atggtctgca gctttgttat tgttatctat aggattggat gccattattg 91740 
           ctgtaaaata gttcacaaga actcagtcta tgggaaagac tcaaaaattc tttgcctgtt 91800 
           aaagaaaaat caggatattg gactggttag tttaactaaa aagtgatgat actcagattc 91860 
           tgcttggatt cactgcttct cagcagttgt tttgtttctt tctaattgat attttatttt 91920 
           tcagagaacc catttataaaa ctcttcttct tcccttaaaa tcacaaccac acaacagcaa 91980 
           ttaaaacatg ctttgacgta agactgatat ggttttaaac ccagcttgac tatcgaattt 92040 
           tttactttag gcaaaacacc tctgacattt atgtcttatc gtcagtaaaa aggggtgatt 92100 
           aacagtttta caagattatt caataaataa atataaattc ctccttttcc ttcctttcct 92160 
           ttcttcatct tcagcatctg catgccataa gctcatttta gttctctgga ctcatgttaa 92220 
           catgtcccac ctttcccaaa ttaaacatca tctctgttat tggctccatt cttttcctct 92280 
           catttgagac aattctttat caaccaacac cctctctgct ctgtattgtg aaactctgct 92340 
           cctactacat taacagtctc ttggtttctt taaaaagaag acaaaacaat taaagaacag 92400 
           aagcaaaaaa tctactcaaa tccccaattg ttaccctcaa aattaattgt cccaccccta 92460 
           gctttctcat tgcacaactc tttgtcaaaa tgttttctac catcacagcc ttcaatgatc 92520 
           tttctggttc ctttatctcc tgaagtctga cttctacctc catctttttc tggactattc 92580 
           aacacacttt gagaaaaaac atacttttgt taaacaggta tgcatccctg aagcataaaa 92640 
           tacatagtac tgaaagtgca catgtgtggt tcttcccatt ttttttacag cacttgaaac 92700 
           tgacaagtag tagtaccaat tacttagtaa aagacctttt tcatttcatt tctgaaatat 92760 
           tgttattttc ctttttcatc ttccatctct gactacacct ccaattttac ctctttgctg 92820 
           ccttccttcc taagaaagtt cttcatgcaa tgccatcttg tttttcttca cttgcctctt 92880 
           tttctcactt taattttatg aactctgatg acttacctct gtagtgtaac tactcaaaat 92940 
           atgtatttct gaagtctcaa ctccaatctc atattttcaa cttatattta tggaggcatc 93000 
           tcagactcaa cctacctaaaaaatggctta tctgccctaa aatctacttt gttctttttt 93060 
           tctctactgc taataattat cttcctagtt ggtcaagctc aaaacctaat catttttact 93120 
           ccttgtccct gtgtcagctg tccacattca agcagcgtat catttctgca catttttcaa 93180 
           gcaagtcagt aactgccttt tgtttgggac tgtcttttca tatagtgaac agccttggaa 93240 
           gatagaaatc atttctcctt ctaaaacaaa aggcaggtgt gcttgcagcc ttggatagag 93300 
           gtagtgcctc tttctaaagc aaagggacat ctttactggc catttataaaa tatccatgtt 93360 
           tcctgagctc tgcgttcctc ttttctaatg caacccactg agcatgtagg tgtcacctga 93420 
           gcttttctgt gggaattgcg gcttgaggaa tcagtgcaag aaaatcatga tactcttgct 93480 
           aatgctatta atgtgagtag taaagttaat tgtctctgac ccagcactat tgtgtctttg 93540 
           cccagcactc aaaagactgg caggcttgca agtaggacaa aatgttagat ttttcacagt 93600 
           tcttctgctt ataagtactt gttaaaacca attaaaacac aacttgtagt ttgcacctat 93660 
           aattttgtag catttgcttc ttatctatgt cactaggatg tgcttagtga cagacccatc 93720 
           tatcatctat tactcaagtt tttggctgta ttcctaggca acagagagaa ggggaacaaa 93780 
           caagaggacc tgtgcacagt ttgagaaagg caaaacaccg agcttaattg cagacttgaa 93840 
           tgtagctagc aaacgaagta aggcaaaagg ttccttttttttttttttag atggagtctc 93900 
           actctgtcgc cagtctggag tgcagtggtg ctgtctcggc tcactgcaac ctccgcctcc 93960 
           tgggttccag cgattcttct gcctcagcct cccgagtagc tgggactaca ggcatgtgcc 94020 
           accatgccca gctaactttt gtatttttag tagagacgga gtttcaccac gttggccagg 94080 
           atggtctcaa tctcttgacc ttgtgatccg cccattcggc ctcccaaagt gctgagatta 94140 
           taggtgtgag cctccgttcc cggccaaaag tttccatttt ttaaatagtt gggtttttag 94200 
           tttcgattct ttccaaaaaa aggttttctt aaaaaaataa aattagcaat aagatgaaat 94260 
           ataacaacaa tataatctta ttaagacaat atatgatata catttatcaa aatacttata 94320 
           ttttcaaaag tgcttaaaat aatctagcac atagtagatg ctcagtaaat atttgatatt 94380 
           atgactgtgc atgggtcatt ataggctact ttatgtatat catttcattt agtacaacat 94440 
           cactctgaaa aatgttttat tgttaccgtt tttcagttga aacatttacg ttgctcaaga 94500 
           tctcactggt accatctact attaggtcag tctgccacca aatctcatgc tcttaaatgc 94560 
           cctttttctc ctgagcttcc aacaaatagt gtactgtata taattgttga aggggagggga 94620 
           ctgtgagaca aaatatttag agtgaatgtg tagccacaat ttcagttcct caacaaagtg 94680 
           ataaaattag gaatcatcct caatatatat tcttccaaca cacacacaca catacacaca 94740 
           cacacacaca caaataccac aagccactt gaatgcaccc cacctacaca ttgcaaccat 94800 
           agagacaatt gcagcattaa atacagaata ttctgtgtgtgttgtttgtttg ttctcccttt 94860 
           gctacaaaaa tcagaatttc tactcaataa acagcaaagg gagatacaaa tgaaccaaat 94920 
           taaagaagga aaaaatgttg aaaaaattat atacagaact atgtattgat ttatgagag 94980 
           ttcagtaatg taatccagaa ataatggatg ccttaaaagt aattaaaaga atgcaaataa 95040 
           acatttagtg ccaattaaag aaaaagaaat acaacattag acaaaataaa agatattcat 95100 
           ttgatgcaat gaggaaataa tcttttattc ctctttaaat tctctgtgga ataaggcatg 95160 
           gttataaata aataaacatc tgccccatgg acttaatgga tcgttatatt ttattgcgat 95220 
           aatcataatg aaattgttgg gagggattag tatctctagt gtaatgctaa gaaagataaa 95280 
           gcctgtgccc aggcaaaagc tttcttggtt ggtcaaaagg tttgaagaca tttcaaacta 95340 
           ttctaaaaca aacaaacaag caaacaaaca aaaaacatac aatgtctttg ccacatattt 95400 
           aggaaacaaa atgaacaatt tatttctgac aacctcatag tctttgttct gtcagaacaa 95460 
           taatggaaag gtctaaacca gaaaatgcta tgcattgaat ttataataaa ctattttttc 95520 
           ctgtaacaaa aaattgataa acttgatatt tgcagattta atgattatgt gtttaaaaaa 95580 
           aatctggttt ttgcccttgc aaaaaatcat atatatacac atagatatgt atgtgtgtgtgt 95640 
           gtgcatagta tatatatatg tatatacata tatatacaca catttatata tataaacatt 95700 
           tcctttaacc tcctatttta ttccaataaa aatattggta ttagagatag ttctgatatt 95760 
           tcatcatgaa tagttaacat tgcatttgga aaggattaat ttttttgaaa cgtaatttta 95820 
           ccttaataag tagcccagcg taatatttta gtaattacac agattttttt ttcaagacat 95880 
           ttgacaacta atattgcata atagttaaga gtgtggggctt tggagccaga cttcctatct 95940 
           ctgttcattc actgataaaa tggagacagt agtaacttcc tcaaagagtt gttttttaag 96000 
           atcaaataat gcatataaaa ctcttgaaat ggtaccaaat acagagtaag caccaaataa 96060 
           acattaactg ttattgttat tccatgtccg aataacacag aaaagtaaga attttaatat 96120 
           ttcatttgaa tgacctttta aggatacacc tagcccatta tctttcttga taatcttgta 96180 
           agatgattcc ttttttatct ccgatctgtt gaggcatgga tagaggtttt cagagaaaac 96240 
           attttctagg taactgaaag aaagtagcaa caacaaactg tgacaaaact taacaatgag 96300 
           agaatttaca agatagaata attgcaactc cttttgaaat caaccactat ggtcctctgg 96360 
           ctgggatagc taagcaaaga tattccagcc tgaaggttga gatctacttg aagagttttc 96420 
           tatccagatt gtgagggccc ctcaaacttc acttagtatc tgtttctatt agtatggaaa 96480 
           cttctggaac cttgtggtat cacattcact tgactacttt attcctgctc tagctatctt 96540 
           aaagcctttc ttaatctttt atcttttaga gaagatactt ctaggtttta aatccaccga 96600 
           tcttgaagct attgccttca ctctctgctt cagagcccat ccttttgtat atgagtagtt 96660 
           tgttttgcct aaagtacttt ctcccagtca gattttaagt ccagtttctc atctgttttt 96720 
           gagagcaaac tcctgggcct tggctcacta acatcttgac agcatatttc ttctttccta 96780 
           tgggcttttc agcattccct gggtttttct aaaatatgaa agcagactct ttatctctta 96840 
           ctttgtcaaa gcctaccctc cccactgatt tctcacccag ttgctagttt taagacctgc 96900 
           ctctggccgg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccaaggtagg 96960 
           tggatcacga ggtcaggaga tcgagaccat cctggctaac acagtgaaac cctgtctcta 97020 
           ctaaaattac aaaaaaatta gccaggcgtg gtggtgagcg cctgtagtcc cagctactcg 97080 
           ggaggctgaa gcaggagaat ggcgtgatcc cgtgaggcag agcttgcagt gagctgagat 97140 
           cgcgccactg cactccagcc tgggcgacag agcgagactc tgtctcaaaa aaaaaaaaaa 97200 
           aaaaaaaaaaaaaaaaagac ctgcctccaa atatcattgt atttgcaaac atgaaatgac 97260 
           ttattgattc tgagctcagc acaagagcaa acctttctca gcttgaccca tcttcacatc 97320 
           gttaatgtct tattcagtca ctacccaagg ggctgacctt caagattcta atccatgaaa 97380 
           gcttaaaata gtaaacaaat ttgaatatag tttaacatac ataataaatt ttatttctag 97440 
           aagaggagga tcagccctta gacatgaaaa gtaaaaatag tttattccca gatttccctt 97500 
           tgtgcattag tatattcaac cgagtctatc caagtaacag gacaaaaaaa gctggcagtt 97560 
           gttgctgcgc tgtgaagtct tattagggtga gtcagctaat tatatggcac taccataaat 97620 
           acagcaggca ctgccctgct tgttaggctt gccaaggaaa ataaggattt aaagcagcat 97680 
           actacctctt tgctatataa tgacattttc ttcttaaaaa tgattttgca ccaattcctg 97740 
           atttatccac caattatttt ttaatttatg gttgaatgta tttaaacctg aattcagaga 97800 
           taaaactagt aaatagctcc ccaaaataac cccaaatata tttaatatat tagctttact 97860 
           ctctcctcca ctgccaaacc tttaaaaact gaaataaatt gtttttattt catcttttct 97920 
           ctttttctct ctctctaagg tgattgccaa gactaaagaa acagctagaa gggcaaaaga 97980 
           caagaaaatc agtaagatag taacagatta tccaaagtag agcacggctc aggtgcagtg 98040 
           gctcatgcct gtaatccccag cactttcgga ggctgacgca ggaggatcac ttgagtccag 98100 
           gagtttgaga ccagcctggg caacataatg aaacttcatc tctataaaaa aaaaaaattt 98160 
           aaatagccga gcatggtggt gtaagcctat agtcccagct atttgggagg ctgaggctgg 98220 
           aggatcactt gggcccagga gttggagact acagtgagct atgattgtat cactgcatta 98280 
           cagcctgggc aatagggcaa gaccctgcct ctaaacaaaa gataaacaaa gtagagcata 98340 
           aatggcttct aaatatatgt tatttatgtg taagactggg ttctctaaag gtatcattta 98400 
           attaaaatag atttgcattc tcaatctgta ggtatggatt atgtataatg tattaagat 98460 
           atgacttaca gcgttcacca atgtgactat tcccaagtga tccagatggc tgatgacata 98520 
           gtaatttgta catttgctga gacctgatct gagtaggtat gtaacataac tgagggagag 98580 
           caagtccatt tgccgaaaga aagcctagca tatgacccag gagccacatc ttcactcagc 98640 
           cttgttgcta ggtttggctt agcatatata atagcatagc atgtataatt tatgacaaaa 98700 
           aattatactt tgcacttttt aattagaaca ttcaaaatga tctcaggaag tggcaccaga 98760 
           gatcatcagt ggtctactgt acttcgtgtg tatgtgtctg tgagtatgta tgtgtttgtg 98820 
           tgtgttccca cattctaagg catgtctttt acaggttagt agaaaatgtt gatagaaaat 98880 
           tatagatttc aacatctaaa acacagtagg tcactacatt gttaaaactt ggaatttttt 98940 
           atcttgttgt aaagtcaggc caaccaaacc taaaatactg ctacattgaa atagtgcaaa 99000 
           atattcaaaa tactatagtt atagatttgg tagtaggact gtaccagacc tgtcactcta 99060 
           tacaagactt atgccttgcc ctttcactta cctgttccct tttacatcta tcttactaga 99120 
           tgtaatgcta taaattatat ttctaatata ttataattta tcatgtatta taatgtatca 99180 
           aatattacaa attatgttgc aactccccctt acctttcgtc tgcatattgc ctcagaaaga 99240 
           acaagatggat ccaacagact tcaaccacag gcccttagtg acaaatagct cttaatgctg 99300 
           ggcttgccac tttgatgcat ttctaaagtt atagaatgtt aaatgcacca agtcctttgg 99360 
           tcattttatt tctaccttag atctaagcca taactatact ttcccaaaaa ttaaagtttg 99420 
           aattttaact taaccatata taattggaaa aggaggttgg gttcgttaag tgtaatttta 99480 
           tcatgcttta ttatcctttg ggcattggat acagcagaac atgccaattt ctatggcttc 99540 
           tcatgtgaca gaatatactt actaggatgc aattaaatac tcctcagagt atgtaaacaa 99600 
           taaatgtaat cattacatta tttttatatt gttctttctt atgcataata gtaagactga 99660 
           aaatatagtg ttatttctga aatatgcata ttgttttgct tttgatgatt aaataacatt 99720 
           gtccaaagtt ttaggttttt tgaaatctta tattttttaa caaaatatct agcctttcca 99780 
           aaacaagacc tcaataattc gtttaagacc cagagttgtt cctctccaca tagatctctt 99840 
           aaaaaggcag aggatttatg acctcaagag aaatcagagt atccaaagtt tgctttaatt 99900 
           caatgtttta aaaataaaat tccttagatt ttatcaaaaa ttgagattag tttgattttg 99960 
           aatcagatgc cctttgctcc ccaccccaaa atggcattat gagcagacta ggaattgata 100020 
           atagaaaatt gaacatatga aatatatctt taccttgctt tttaacaagg tattcatgtc 100080 
           tatcgccttc atttttaagt gcatcaataa aatacatggt aattctctta gtgaaatata 100140 
           ctatctacac tatgtacaca ctcccctgtc tgaggtagag aagtagagaa tattcacatt 100200 
           tttgaaacgt ctatgctatt tttattaaa tacgagttct gggcttgatt tcattttgga 100260 
           acacgggtgt gtgcttaagt tgaacctttt tttccctctta agtcaaagtt cttttttagt 100320 
           ttcttctttt atctttttgg ctactatctc tctccttcat cctcctggtg tgagttgttg 100380 
           agtgaaggta ttaattccat tatttgaggc taagtgacat tgttcaataa tgcagcaaaa 100440 
           caatggttct acccaaaata tcttcaagtg taaaagcagt gggcaaaaga gaaagtgcgc 100500 
           ttctgctgct ttgaatgttt aaggctgtga aagttgatca cacaaattgg gtcattcttg 100560 
           ttatacccaa ctaaaacaat caagaagcct gggaggaaaa gcattcaaga aacatcacat 100620 
           tgctccaaaa gtgtaatttt ctacaagtcc gcatgctgag gctgcctgtt gtaacctggg 100680 
           accaattttt tctgtaactg ctgaaaaaac ttgctgcagc tctaggacta attttgccca 100740 
           ccactgtcac tcaccaattg aagcttacta gctccccaga acctttctag tgccaatgaa 100800 
           ctttctcaaa gagcagcgtg tatcatttct ctttttcaga acacctccaa cctcctcttt 100860 
           gttctttggg tataccaaag accaaccagc cttgaatttc aatttttctt cccacataaa 100920 
           agttttaatt tagaaatgta tctctacatt tctaactttg acaaagcata gataccagat 100980 
           aattgatgaa accttgctat tttaacgatc accatggatt acttcccagt gtcttcagat 101040 
           aaccctcaac atttgccaac atttgatgga cttcaaaatg agcatatctt ttttaaaaaa 101100 
           aattattcac actgacagca agtacattgg tatactctat attaaattat accacagggt 101160 
           ttacaaacaa ttggtgatgt cgggcagtgg tttccaagga acatacttaa caagacactc 101220 
           acaaggccct acaaacctgc atttttaaca agggccctag atgattctag aagagtgtgg 101280 
           tttggaaagc aatttttgcc tttattatgt gtcattttaa atatatttaa aattaaagtt 101340 
           ataagtcata gaattgaata aagataattt ccttacagaa agtattacta ggtatctaaa 101400 
           tacaatatgg ttcaaaacag gaaatttaaa aagattatgt aaattctgta gttgtattcc 101460 
           taaagacagt agctgaaatt ttttcctact tctccttgta tcacttccct tttccttcac 101520 
           tttcacttcc ctggaattgt acttcccaat aagctattag cagtgaagga agcttcgtct 101580 
           catgatctgt tttatagagc acttcagctg ggacgagtac gaaatgataa tcagttatat 101640 
           cagctattca accctacagg tttattaaa aagaacttga ataagctttt tagggagaaa 101700 
           gaggtcagtc tcagccattt ctgtttccta atatagcttt taagtctttc cttattagca 101760 
           atgagggtca ttccattgta attttttgat aaccattttt ctttctgtgt gtcaaatgca 101820 
           gatataagat actgaactga gtctatttca ctgttcgtaa aacaatccca tttgaaaaaa 101880 
           aaaagtctac agctattcca gggatagggc ctagtagaga gagaataaaa ggtattttct 101940 
           tactatgtct ctatatccta ccctgtaggt tctcttatta agcatacagg catataccaa 102000 
           aatccagacg tttttctcat ttatttatt gccctaacat attctgggtt aatataatat 102060 
           cataatgaaa atttgagaaa aaattgattt tttcaaaagt gtttaacatt tgttatattg 102120 
           gtagttttttttcttgtttg tggtaaaaat aaatagaagg tgcacttcac accttcaagt 102180 
           atgattatat tttgaaaaca agtcatgaat actcataaaa tgcaaatttt aatgttcttt 102240 
           ttttgttaca gccaaactat attaggcaca gttgtaaatt ggagttgaaa tttaatattt 102300 
           ctttatagat aacaatgttt ttagaaatag gtttatgaaa cagtaaatat acaggtatag 102360 
           ggataaaatt gtgtctgatg gtcatatgaa gtgtttgttg ttatattctc cttggaatag 102420 
           ctgccaaata ttttagtatg cttaaaatct acgaatgtga tagagtcaac aaatttagat 102480 
           cacatattca gaaaaacata gttagagaac taactattga aatgagcata cagcagtctt 102540 
           cctttatcta cagggataca ttctgaaacc cccactagga cacctgaaat tgcggatagt 102600 
           agcaaaccct acatatactg ttttttccaa tgcttatgta cctatgaaaa agtttaattt 102660 
           ataaactagg cacagtaaga gattaacaac aataactaat aacaaaagag aacaattata 102720 
           ataatatact gtaataaaag ttatgtgggt atggtctcgc tttctctttc cctctctctc 102780 
           tgtctctaaa tatcttagta ttttggggtt gcaattggtg gtgggcaact gaaaccatgg 102840 
           aaaacaaaac cacggataaa aggagactac tgtatatact ttttaaaact gatgaaatat 102900 
           taaactcatg tttcttctat atccaccca tttcccccac ccaaacctag atagatatct 102960 
           tatttgatct gtaaacattt aattaatttg taaaagttaa gaactttttg aagtaaaact 103020 
           gcaatatatc atcacaccta aagaaataaa caataattct taaatatcaa gtcagtgttc 103080 
           aaatttcccc aactacctca tatgtgtttt ccatttgctt atgtagggtt cccaatgaga 103140 
           atgaaataaa gttcttagt tgcaattggc taatgctctc tcacttctac tttaagcggc 103200 
           aggttcccac taacttcttt ttagttgcaa tttacttatt gaaattagac gtattctttg 103260 
           tcttgtgtag tttctcacag tgcaaaattt gctgattgta gccactgttg taagcaatga 103320 
           acatgttttt caccacctta tattgctgt aagttgtcag tgatagttaa atgttaatca 103380 
           aattcaaatt cggatcacgt agggcttttc tttttttgtt ttctttttct atttatatat 103440 
           ttatttattt attttgagac ggagtctcac tccgtcacca ggctggagtg caatggtgtg 103500 
           atctgggctc actgcaatct ccacctcccg ggttcaagtg attcccctgg ctcagtctcc 103560 
           cgagtagctg ggactatagg agaaccacca cgcccggcta actttttgta ttttagtaga 103620 
           gatggggttt caccatgttg gccaggatgc tatagatctc ctgacctcac cgatcatgta 103680 
           ggacttcaat tgtcgaacaa acgaaccttt aatagcagtt acaccattag gatgacctga 103740 
           tccaacatcg aggtcgtaaa ccctattgtc gatttggact ctagaatagg attgtgctgt 103800 
           catccctagt gtagcttgtt cccacttgat gaagttatg gatcagtgaa caatagccca 103860 
           cttaaactag tacagtctta gtttaagatg gtgatgtgta tgtacttcca tcagagggca 103920 
           cataatacag taaatcctca cttaacttca tcaatagttt ctggaaactg tgacttgaag 103980 
           caaaacaaca tataacaaaa ccagttttac cattggctaa ttgatataag caagaattaa 104040 
           gtcctatggc aaatttctgg acacaaaaac accatcaaac tcctaaataa agataaatca 104100 
           cttctgacat taaacattga aattaatgtg agctatatat acgtttaaga aagattaata 104160 
           caaacaagtc aaataactta cctaattatt tcggtggagg ccgcaggtgg ttggagccta 104220 
           tcctggcagc tcagggagca atatgggaac ccaccccgga caggacgctg ttccattact 104280 
           gcagggtgct cttgtacaca cccactcacc caggctggaa ccatgcagac acacacactc 104340 
           acctaaccta cacatctgtg tacatccttc aaagttcagc caaataacat ataaacaaat 104400 
           ccagtaatat ccatcagtct tagttccgtc ataacaactc ctttttgatc atcaaacaac 104460 
           aaacagggta ggtctgccat atttacttgt ctggtccata tcaaaatttt ctaacaaatt 104520 
           atattagaaa atcaaatctc tgtcagtttc aaaatcatgg aaaaaaattt gccttatttc 104580 
           ccttatactt ggatatccta acagtaatct aaatattaat gagaaagtta atgatgtcgt 104640 
           ttccttctcc ctgttgtaaa gaaggttttg ctgtcccgtt tgatcactaa gactaattga 104700 
           cactcagaaa aagcatagga aacttctcag catcacaaaa gctctgtcat ctagagaagc 104760 
           taggacttga gctcaagtcc tgtgacatgg aaggccttgt gcctagccat cctgcagcag 104820 
           aggcgtatct accaagaagt gaaacactac gaaaacagta tgtttactcc aattttaaa 104880 
           gtgaggtagt ttggggtggt tcatatttta tttaatttat atattatttg gatttttttt 104940 
           agtttataaa aagggcattg gcaagggcag aatgatctgt aagcttctct gcccacctac 105000 
           cataagcatg atctttagtg tgaccttttc ttactgttag ccattttctt atacttctgc 105060 
           gtccctgtca gtcacttcca tgtgaagaca tggggaagct tttttacatc agacatgttg 105120 
           ttgaaaatca gccgcgttgg ctgagggatt atttgatctc tttctccaag tccctttagg 105180 
           ctcacattgc ctctctgttc tttgaatttt cacttacctt tatcttctta taattacttt 105240 
           gctgaaataa atgcaaagca acaaaaggta tttagtgaag aataccaaca aagccatgac 105300 
           catttcaggc tgagttttgt agtattcttt gtctaggaag agatacctag aaaaattttc 105360 
           tgaccatgta tttgattatt ttccttcaat atgtatagtc tcagtcttca aatttcagaa 105420 
           aagaatttgtttcttcattg tcatttaaaa ttaatgtgtt aaatatgtat gcttttacat 105480 
           tataagtggt tataaaagtt aaacacttag aaaaaaagtc aaaataacat acatactatc 105540 
           caacaaaata actttcatat tttattgtgttttcttccaa actttttacc tttgcgtctg 105600 
           aattctgtgt aggttgtatc tataatatag acaacacttt atagcctgct aaatattata 105660 
           ccataaatag gtagttgtta cataattctc aggtaatagt aatacaggtc tttatcataa 105720 
           tctactgagt agttgaatga taattttttt taagacaagg tctccctctg tcacccaggc 105780 
           tagaatgcag tggcatgcac atggctcact gtagcctcta cctcccaggc tcaagtgatc 105840 
           ctcctgcctc agcctcccaa gtggctggga ctgtaggcat gtgccaccat gcccagctat 105900 
           ttatttgtat ttttagtaga gatggggttt cattgtaaca gcccaggctg gtcttgaact 105960 
           cctggactca aatgatccac ctgcctcagc ctcccaaagt gctgaaatca caggagtgaa 106020 
           ccactgcacc cagcaataat tttttaactc ttcattattc attgaacatt tagttaacaa 106080 
           ttctaaaaat tttgtttcct gctgtcattg atcttgtgaa aaatatcttt ggactatagc 106140 
           tgtggattat ttcctaaata gtaaattact tgagcaaaaa gtttacatac tttgagggtt 106200 
           gataacccat gttgccgcaa tgtttccccg gaggcattgt ggagtttaga atgccagtag 106260 
           taatattaag gtgtgccatt ttcaagatcc gtggccaaca tccctatatg taagattttt 106320 
           ccaaaacatg gttctgattt ttaaaagtga aaaatgctac ttcatcatgt tctttttgtg 106380 
           cttcttactt taaatattag aatgaagaag gagccccaca ggaaggaatt ctggaagata 106440 
           tgcctgtgga tcctgacaat gaggcttatg aaatgccttc tgaggtagga gtccaagctg 106500 
           aatctttcta acaagacagt accaaaaacc tgtcattgtc aatttctct ttcattagtg 106560 
           cttagtgaga atcatttgct ctctacatgc tcattacgtg gacaacttgc aagttaagaa 106620 
           tagttttac atttttaaag ggtccttaaa aaaaaagagg aggaggaaga tgaagaagag 106680 
           gaagaaagga tgtaaaagaa atcatatgta gtccacatag cttaatatac ttactacttg 106740 
           accctttaca ggaaaagttt actaacccct gcattagaga atatattttt agaaacttta 106800 
           cattctaaaa taaatttcta aatggaaagt tagggaaatc aatggaatgc caaaggaagg 106860 
           ttattatttt ttgccataca tgtccaatgg gatgacgcat agtaaaataa aagttaccca 106920 
           cacaagttat agaataaaaa gataaatgca tgatttgcga caattgatat attccagtat 106980 
           aatgttttaa acaacacaat atgattgtta attttatttt gattgaaaat gaaagtatct 107040 
           ttaatagaaa atgtatcaaa agggaaatta gaaaatactg ttagatgaat aaaactggcc 107100 
           caagaagaaa cagtaaatct gaatagattt gtaacacagc gaatagatta aattagtaat 107160 
           aaaaaaaaaa acctacctgc aaagaaaatc ccaggccgag atggcatcac tggtaaattc 107220 
           taccaaacat ttaaagagga attaatacta attagttaac accaattaat atctcttaca 107280 
           aaacagaaga ggagacattt cccaactaat tttgtgagac caatattacc ctgataatca 107340 
           aaaccaaatg aagatatcac aagaaaagaa actatataat ggctccatta aaaattgagt 107400 
           tcaagtatgt tgtagtttgg ttatgtatta ttcctcacgg catttattaaa aggcatgtcg 107460 
           aggatgggca cagcagttca cacctgtaat cccgcacttt gtgagccaaa gtggccaggt 107520 
           tacttgaggc caggagttgg agaccagtct ggccaacatg gtgaaaccccc atctctacta 107580 
           aaaatacaaa aattagccgg gcatggtggt acacgcctat ggttccagct acttgggagg 107640 
           ctgaggcatg agagtcactt gaacccagga ggcagaggtt gcagtgagct gagatggcac 107700 
           ccctgcactc caatcttggt aacagagcaa gactgtctca cacagacaca cgaaaggcat 107760 
           attgataata attcaactta tagaaattga gattaaattg tttgtttgcc taataagaat 107820 
           ttccaatatt ttggggtctt ttatgcaaga cacagtacta aacacaatgg aaaactatag 107880 
           agtaattgac attaccagga cataaggagt ttacagtctg gtaggtttga tgaaaaaaaa 107940 
           tagaaattca ttcattcatt tcttcattat gattccttta acaaacataa ttgattgtct 108000 
           tcgatgtacc aggcatcaca ggagcaaaaa tatataagac atactaaaaa gtaaaacatt 108060 
           ttaaagatct gtttcaatca atcaggagaa gttttatga ggaggtaatg ttgatctggg 108120 
           tgggaaaagg taagagatat ctagtaggtc aaaacaaaca gaggacattc tggcacaagg 108180 
           gaatatcaga agcaaaggca tgtatgtctg agcatgcaaa tggatatgtc tgagaacagt 108240 
           gaataattat gactcaagct taggaacaag gaaaatggtg atagattgaa tttgcagcta 108300 
           tgggtcaaag acaagttagg ataatcttgt catttcagct tgtattctat 108360 
           tcagaaaaca acttgagtta ttgaagttat gcttatttgt ttgtttttaa gcagaatcct 108420 
           gatattatta gagttgctct ttaggaggaa taatctgatc cctttaatta aatccattaa 108480 
           tatttgtgtt gtggatgcta tccagatact gtatggagag cttgaggttt gaaatacaag 108540 
           taataattga agccatagat gaagacgaaa ttttcaactg ggagagtgaa agtagggaaa 108600 
           atgtatcttg ccttcaaaca tcttaatttc cttctgagaa ttagagcatc ttagtctgga 108660 
           aaaggcttta tagacagctt gattttgttc tcacatttta caggtgaaga aactgagaac 108720 
           cagacagtcc aacttatttg tcctaccaaa ctaggtatat gatcattaaa tggtgcatcc 108780 
           ggatcagaac ctagatattt taactctgac tactactgta attcactttt atatcagaca 108840 
           agaaagacac aactattaaa aataagataa tatttgctgc agaatatttg caaaaacatt 108900 
           gattgtaaat tttagtgtaa gtggggagcc atttcctatc tcattggctg tcagtgctga 108960 
           tgcgtaattg aaacttatac taacagtgtg tgctgtcttt ttgatttttc taatattagg 109020 
           aagggtatca agactacgaa cctgaagcct aa 109052 
            <![CDATA[ <210> 2]]>
           <![CDATA[ <211> 114226]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Sapiens]]>
           <![CDATA[ <400> 2]]> 
           tattttcata tatgtatata tttattatgt cacaaatagc tacatactgg ataagccaga 60 
           aagatgagga aacatgtttg catctcacac tagtgcagag attctgaaaa agaccccact 120 
           tggaatacca aaccacacat tagattgttc tgttcccaat tgtgtgccaa agtgcactct 180 
           gaactgtttt ggtaaagccg accgtggagt catatgaggc tgaataactt gggagaatgt 240 
           aagtctgcaa aataaaccta ggactggatt gatcctcagg ccacttggca ggtgaatgtc 300 
           tcgggagtga atatgagaca agcttcctga aaaggcttat atgacttaaa gaactttttg 360 
           tttaagtgtt tggtcccaaa taaactatta agatatataa agtaattcac tgctcaaaaa 420 
           ttaccgtcag ataaatatta agggaagaaa cactttaaag gagaatttgt atccacataa 480 
           atccttaaat tcatggtcac aactttccta atctcaaatt gttctaggtc actgctatca 540 
           gtctagttct gtcctctatt tcttaattta ataccaatac ttttaaattt ttaaaatatg 600 
           ctgctttagg tagatttaaa atatatccta accgccactt tctaaccttc ctgaaatata 660 
           ctgttcaata acaaatcctt tccttgctta aacataactt aaataaaaca agaaacttac 720 
           catttctctc tagtgtaaga tgacacatgc agcttagcac tctgtagtag tctctcttca 780 
           attaggtaaa aaaggaagtt tctatggtaa ccatccttat agtcactcat tcctccttcc 840 
           ttcctcacca gcgcccaata tatatcacat tactcatgaa tacatataaa ctgctagcat 900 
           gtctagaata ttctgtcttg aaattatact ttctactagt gacttttaga aatgactatg 960 
           ccccagaata attaaaaaga gaaaccaaat aatttttaaa ttaatttata cagagttttt 1020 
           caccatcaag tttattttca gcacccatgg ggagttaata gatcttccct gaaagagaaa 1080 
           aacctttcct aaggaaaaat cctagaattc atatatttgg caacatttaa aggaggccat 1140 
           gaaattttta tcagtctaga gaattgatct cctttaaggt gactctggta gttccaacga 1200 
           tgtttaaagg catttcctgt aaaaaaaaaaaaaaaaagag agcgagagaaaaagagagag 1260 
           agagagagag aatttctgat gattaaaaaa aaaaagtgag gaatgctgag ttaaacaaag 1320 
           ttaaccacat tctctcagag ccttgaatgt gctaatatgt gctaatgtgt cttatggctc 1380 
           tctaaggagg gtgtagtcaa aatcatcttc tacactgctt agttcccgggg aacccacttt 1440 
           ttttttttttttattcatgg tcgaatatta tttatgtca gaaaggtaca gcattcacac 1500 
           caatatcaga caaaatagat tttaactaaa aaattatttc gagacaaaaa taacaatata 1560 
           tgttaataaa aggctcaatt aaaaatgtat aacaattata aacacataca catcaaacaa 1620 
           cagttcccca aaatacgtaa agcaaacatt gacaggattg aagggagaaa tagaccactc 1680 
           tacaatagta gttggggtct tcaacaccccc actttcaata attaatcaca gccacttaag 1740 
           gaaccagtgc ataccaaaac acacttctgg cagtgttgct tcagggaatt ccgagtgtag 1800 
           ggttaatgtt ccattttctc tacctcttct aaaattcctc cttcttcaaa tggctattaa 1860 
           taactttata tttttgtcct ttgtgtcagt tcttaattca tgttgcttat aagcatgatt 1920 
           tttattatta aagtgagatg ggataaaaat aaaatatttttgcaatgaga taacgtttta 1980 
           ttttaattct caccattatatatacaaacac aagtgaataa aacacatcgc aaaatggtaa 2040 
           aatttcatat ttagtattta taggtgcata gtttcatgct cacatatttt taagtattat 2100 
           atatattaac aaatttcaca atacgtcatt attcttagac agtatcatta aaagacacct 2160 
           aaaaatctta taatatatga tagcaaatca ctaacaactt ctgaacaaca gcaacaaaaa 2220 
           aatagtgagg atttagaaat aagtggtagt cacttaggtg tttttaattt gttttaacat 2280 
           cgtagattga agccacaaaa tccacagcac acaaagaccc tgctaccatg tattcacttc 2340 
           agtgaaaggg aagcaccgaa atgctgagtg ggggcaggta cagatacttc aatcactgct 2400 
           gatggaagac ttcgagatac actgtaaaaa ctttgagaaa tgtcatgact gggcacattg 2460 
           gaactgagca cttgtacagg atggaacatc tgtcagcaga tctcaagaaa ctgggagcaa 2520 
           agatatttct taggcttcag gttcgtagtc ttgataccct tcctaatatt agaaaaatca 2580 
           aaaagacagc aacacactgtt agtataagtt tcaattacgc atcagcactg acagccaatg 2640 
           agataggaaa tggctcccca cttacactaa aatttacaat caatgttttt gcaaatattc 2700 
           tgcagcaaat attatcttat ttttaatatagt tgtgtctttc ttgtctgata taaaagtgaa 2760 
           ttacagtagt agtcagagtt aaaatatcta ggttctgatc cggatgcacc atttaatgat 2820 
           catataccta gtttggtagg acaaataagt tggactgtct ggttctcagt ttcttcacct 2880 
           gtaaaatgtg agaacaaaat caagctgtct ataaagcctt ttccagacta agatgctcta 2940 
           attctcagaa ggaaattaag atgtttgaag gcaagataca ttttccctac tttcactctc 3000 
           ccagttgaaa atttcgtctt catctatggc ttcaattatt acttgtattt caaacctcaa 3060 
           gctctccata cagtatctgg atagcatcca caacacaaat attaatggat ttaattaaag 3120 
           ggatcagatt attcctccta aagagcaact ctaataatat caggattctg cttaaaaaca 3180 
           aacaaataag cataacttca ataactcaag ttgttttctg aatagaatac aagctgaaat 3240 
           gacaagatta tcctaatact ctataacttg tctttgaccc atagctgcaa attcaatcta 3300 
           tcaccatttt ccttgttcct aagcttgagt cataattatt cactgttctc agacatatcc 3360 
           atttgcatgc tcagacatac atgcctttgc ttctgatatt cccttgtgcc agaatgtcct 3420 
           ctgtttgttt tgacctacta tatctcttac cttttcccac ccagatcaac attacctcct 3480 
           caataaaact tctcctgatt gattgaaaca gatctttaaa atgttttact ttttagtatg 3540 
           tcttatatat ttttgctcct gtgatgcctg gtacatcgaa gacaatcaat tatgtttgtt 3600 
           aaaggaatca taatgaagaa atgaatgaat gaatttctat tttttttcat caaacctacc 3660 
           agactgtaaa ctccttatgt cctggtaatg tcaattactc tatagttttc cattgtgttt 3720 
           agtactgtgt cttgcataaa agaccccaaa atattggaaa ttcttattag gcaaacaaac 3780 
           aatttaatct caatttctat aagttgaatt attatcaata tgcctttcgt gtgtctgtgt 3840 
           gagacagtct tgctctgtta ccaagattgg agtgcagggg tgccatctca gctcactgca 3900 
           acctctgcct cctgggttca agtgactctc atgcctcagc ctcccaagta gctggaacca 3960 
           taggcgtgta ccaccatgcc cggctaattt ttgtattttt agtagagatg gggtttcacc 4020 
           atgttggcca gactggtctc caactcctgg cctcaagtaa cctggccact ttggctcaca 4080 
           aagtgcggga ttacaggtgt gaactgctgt gcccatcctc gacatgcctt ttaataatgc 4140 
           cgtgaggaat aatacataac caaactacaa catacttgaa ctcaattttt aatggagcca 4200 
           ttatatagtt tcttttcttg tgatatcttc atttggtttt gattatcagg gtaatattgg 4260 
           tctcacaaaa ttagttggga aatgtctcct cttctgtttt gtaagagata ttaattggtg 4320 
           ttaactaatt agtattaatt cctctttaaa tgtttggtag aatttaccag tgatgccatc 4380 
           tcggcctggg attttctttg caggtaggttttttttttta ttactaattt aatctattcg 4440 
           ctgtgttaca aatctattca gatttactgt ttcttcttgg gccagtttta ttcatctaac 4500 
           agtattttct aatttccctt ttgatacatt ttctattaaa gatactttca ttttcaatca 4560 
           aaataaaatt aacaatcata ttgtgttgtt taaaacatta tactggaata tatcaattgt 4620 
           cgcaaatcat gcatttatct ttttattcta taacttgtgt gggtaacttt tattttacta 4680 
           tgcgtcatcc cattggacat gtatggcaaa aaataataac cttcctttgg cattccattg 4740 
           atttccctaa ctttccattt agaaatttat tttagaatgt aaagtttcta aaaatatatt 4800 
           ctctaatgca ggggttagta aacttttcct gtaaagggtc aagtagtaag tatattaagc 4860 
           tatgtggact acatatgatt tcttttacat cctttcttcc tcttcttcat cttcctcctc 4920 
           ctcttttttt ttaaggaccc tttaaaaatg taaaaactat tcttaacttg caagttgtcc 4980 
           acgtaatgag catgtagaga gcaaatgatt ctcactaagc actaatgaaa gagaaatgtg 5040 
           acaatgacag gtttttggta ctgtcttgtt agaaagattc agcttggact cctacctcag 5100 
           aaggcatttc ataagcctca ttgtcaggat ccacaggcat atcttccaga attccttcct 5160 
           gtggggctcc ttcttcattc taatattaa agtaagaagc acaaaaagaa catgatgaag 5220 
           tagcattttt cacttttaaa aatcagaacc atgttttgga aaaatcttac atatagggat 5280 
           gttggccacg gatcttgaaa atggcacacc ttaatattac tactggcatt ctaaactcca 5340 
           caatgcctcc ggggaaacat tgcggcaaca tgggttatca accctcaaag tatgtaaact 5400 
           ttttgctcaa gtaatttact atttaggaaa taatccacag ctatagtcca aagatatttt 5460 
           tcacaagatc aatgacagca ggaaacaaaa tttttagaat tgttaactaa atgttcaatg 5520 
           aataatgaag agttaaaaaa ttattgctgg gtgcagtggt tcactcctgt gatttcagca 5580 
           ctttgggagg ctgaggcagg tggatcattt gagtccagga gttcaagacc agcctggggct 5640 
           gttacaatga aaccccatct ctactaaaaa tacaaataaa tagctgggca tggtggcaca 5700 
           tgcctacagt cccagccact tgggaggctg aggcaggagg atcacttgag cctgggaggt 5760 
           agaggctaca gtgagccatg tgcatgccac tgcattctag cctgggtgac agagggagac 5820 
           cttgtcttaa aaaaaattat cattcaacta ctcagtagat tatgataaag acctgtatta 5880 
           ctattacctg agaattatgt aacaactacc tattatggt aataattta gcaggctata 5940 
           aagtgttgtc tatattatag atacaaccta cacagaattc agacgcaaag gtaaaaagtt 6000 
           tggaagaaaa cacaataaaa tatgaaagtt attttgttgg atagtatgta tgttattttg 6060 
           actttttttc taagtgttta acttttataa ccacttataa tgtaaaagca tacatattta 6120 
           acacattaat tttaaatgac aatgaagaaa caaattcttt tctgaaattt gaagactgag 6180 
           actatacata ttgaaggaaa ataatcaaat acatggtcag aaaatttttc taggtatctc 6240 
           ttcctagaca aagaatacta caaaactcag cctgaaatgg tcatggcttt gttggtattc 6300 
           ttcactaaat accttttgtt gctttgcatt tatttcagca aagtaattat aagaagataa 6360 
           aggtaagtga aaattcaaag aacagagagg caatgtgagc ctaaagggac ttggagaaag 6420 
           agatcaaata atccctcagc caacgcggct gattttcaac aacatgtctg atgtaaaaaa 6480 
           gcttccccat gtcttcacat ggaagtgact gacagggacg cagaagtata agaaaatggc 6540 
           taacagtaag aaaaggtcac actaaagatc atgcttatgg taggtgggca gagaagctta 6600 
           cagatcattc tgcccttgcc aatgcccttt ttataaacta aaaaaaatcc aaataatata 6660 
           taaattaaat aaaatatgaa ccaccccaaa ctacctcact ttaaaatgtg gagtaaacat 6720 
           actgttttcg tagtgtttca cttcttggta gatacgcctc tgctgcagga tggctaggca 6780 
           caaggccttc catgtcacag gacttgagct caagtcctag cttctctaga tgacagagct 6840 
           tttgtgatgc tgagaagttt cctatgcttt ttctgagtgt caattagtct tagtgatcaa 6900 
           acgggacagc aaaaccttct ttacaacagg gagaaggaaa cgacatcatt aactttctca 6960 
           ttaatattta gattactgtt aggatatcca agtataaggg aaataaggca aatttttttc 7020 
           catgattttg aaactgacag agatttgatt ttctaatata atttgttaga aaattttgat 7080 
           atggaccaga caagtaaata tggcagacct accctgtttg ttgtttgatg atcaaaaagg 7140 
           agttgttatg acggaactaa gactgatgga tattactgga tttgtttata tgttatttgg 7200 
           ctgaactttg aaggatgtac aggatgtgt aggttaggtg agtgtgtgtg tctgcatggt 7260 
           tccagcctgg gtgagtgggt gtgtacaaga gcaccctgca gtaatggaac agcgtcctgt 7320 
           ccggggtggg ttcccatatt gctccctgag ctgccaggat aggctccaac cacctgcggc 7380 
           ctccaccgaa ataattaggt aagttaatttg acttgtttgt attaatcttt cttaaacgta 7440 
           tatatagctc acattaattt caatgtttaa tgtcagaagt gatttatctt tattaggag 7500 
           tttgatggtg tttttgtgtc cagaaatttg ccataggact taattcttgc ttatatcaat 7560 
           tagccaatgg taaaactggt tttgttatat gttgttttgc ttcaagtcac agtttccaga 7620 
           aactattgat gaagttaagt gaggatttac tgtattatgt gccctctgat ggaagtacat 7680 
           acacatcacc atcttaaact aagactgtac tagtttaagt gggctattgt tcactgatcc 7740 
           aataacttca tcaagtggga acaagctaca ctagggatga cagcacaatc ctattctaga 7800 
           gtccaaatcg acaatagggt ttacgacctc gatgttggat caggtcatcc taatggtgta 7860 
           actgctatta aaggttcgtt tgttcgacaa ttgaagtcct acatgatcgg tgaggtcagg 7920 
           agatctatag catcctggcc aacatggtga aaccccatct ctactaaaat acaaaaagtt 7980 
           agccgggcgt ggtggttctc ctatagtccc agctactcgg gagactgagc caggggaatc 8040 
           acttgaaccc gggaggtgga gattgcagtg agccccagatc acaccatgc actccagcct 8100 
           ggtgacggag tgagactccg tctcaaaata aataaataaa tatataaata gaaaaagaaa 8160 
           acaaaaaaag aaaagcccta cgtgatccga atttgaattt gattaacatt taactatcac 8220 
           tgacaactta cagcaaatat aaggtggtga aaaacatgtt cattgcttac aacagtggct 8280 
           acaatcagca aattttgcac tgtgagaaac tacacaagac aaagaatacg tctaatttca 8340 
           ataagtaaat tgcaactaaa aagaagttag tgggaacctg ccgcttaaag tagaagtgag 8400 
           agagcattag ccaattgcaa cctaagaact ttatttcatt ctcattggga accctacata 8460 
           agcaaatgga aaacacatat gaggtagttg gggaaatttg aacactgact tgatatttaa 8520 
           gaattattgt ttaatttcttt aggtgtgatg atatattgca gttttacttc aaaaagttct 8580 
           taacttttac aaattaatta aatgtttaca gatcaaataa gatatctatc taggtttggg 8640 
           tgggggaaat gggtgggata tagaagaaac atgagtttaa tatttcatca gttttaaaaa 8700 
           gtatatacag tagtctcctt ttatccgtgg ttttgttttc catggtttca gttgcccacc 8760 
           accaattgca accccaaaat actaagatat ttagagacag agagagagggg aaagagaaag 8820 
           cgagaccata cccacataac ttttattaca gtatattatt ataattgttc tcttttgtta 8880 
           ttagttatg ttgttaatct cttactgtgc ctagtttata aattaaactt tttcataggt 8940 
           acataagcat tggaaaaaac agtatatgta gggtttgcta ctatccgcaa tttcaggtgt 9000 
           cctagtgggg gtttcagaat gtatccctgt agataaagga agactgctgt atgctcattt 9060 
           caatagttag ttctctaact atgtttttct gaatatgtga tctaaatttg ttgactctat 9120 
           cacattcgta gattttaagc atactaaaat atttggcagc tattccaagg agaatataac 9180 
           aacaaacact tcatatgacc atcagacaca attttatccc tatacctgta tattactgt 9240 
           ttcataaacc tatttctaaa aacattgtta tctataaaga aatattaaat ttcaactcca 9300 
           atttacaact gtgcctaata tagtttggct gtaacaaaaa aagaacatta aaatttgcat 9360 
           tttatgagta ttcatgactt gttttcaaaa tataatcata cttgaaggtg tgaagtgcac 9420 
           cttctattta tttttaccac aaacaagaaa aaaaactacc aatataacaa atgttaaaca 9480 
           cttttgaaaa aatcaatttt ttctcaaatt ttcattatga tattatatta accccagaata 9540 
           tgttagggca ataaaataaa tgagaaaaac gtctggattt tggtatatgc ctgtatgctt 9600 
           aataagagaa cctacagggt aggatataga gacatagtaa gaaaatacct tttattctct 9660 
           ctctactagg ccctatccct ggaatagctg tagacttttt tttttcaaat gggattgttt 9720 
           tacgaacagt gaaaagaact cagttcagta tcttatatct gcatttgaca cacagaaaga 9780 
           aaaatggtta tcaaaaaatt acaatggaat gaccctcatt gctaataagg aaagacttaa 9840 
           aagctatatt aggaaacaga aatggctgag actgacctct ttctccctaa aaagcttatt 9900 
           caagttcttt ttaaataaac ctgtaggggtt gaatagctga tataactgat tatcatttcg 9960 
           tactcgtccc agctgaagtg ctctataaaa cagatcatga gacgaagctt ccttcactgc 10020 
           taatagctta ttgggaagta caattccagg gaagtgaaag tgaaggaaaa gggaagtgat 10080 
           acaaggagaa gtaggaaaaa atttcagcta ctgtctttag gaatacaact acagaattta 10140 
           cataatcttt ttaaatttcc tgttttgaac catattgtat ttagatacct agtaatactt 10200 
           tctgtaagga aattatcttt attcaattct atgacttata actttaattt taaatatatt 10260 
           taaaatgaca cataataaag gcaaaaattg ctttccaaac cacactcttc tagaatcatc 10320 
           tagggccctt gttaaaaatg caggtttgta gggccttgtg agtgtcttgt taagtatgtt 10380 
           ccttggaaac cactgcccga catcaccaat tgtttgtaaa ccctgtggta taatttaata 10440 
           tagagtatac caatgtactt gctgtcagtg tgaataattt tttttaaaaa agatatgctc 10500 
           attttgaagt ccatcaaatg ttggcaaatg ttgagggtta tctgaagaca ctgggaagta 10560 
           atccatggtg atcgttaaaa tagcaaggtt tcatcaatta tctggtatct atgctttgtc 10620 
           aaagttagaa atgtagagat aatttctaa attaaaactt ttatgtggga agaaaaattg 10680 
           aaattcaagg ctggttggtc tttggtatac ccaaagaaca aagaggaggt tggaggtgtt 10740 
           ctgaaaaaga gaaatgatac acgctgctct ttgagaaagt tcattggcac tagaaaggtt 10800 
           ctggggagct agtaagcttc aattggtgag tgacagtggt gggcaaaatt agtcctagag 10860 
           ctgcagcaag ttttttcagc agttacagaa aaaattggtc ccaggttaca acaggcagcc 10920 
           tcagcatgcg gacttgtaga aaattacact tttggagcaa tgtgatgttt cttgaatgct 10980 
           tttcctccca ggcttcttga ttgttttagt tgggtataac aagaatgacc caatttgtgt 11040 
           gatcaacttt cacagcctta aacattcaaa gcagcagaag cgcactttct cttttgccca 11100 
           ctgcttttac acttgaagat attttgggta gaaccattgt tttgctgcat tattgaacaa 11160 
           tgtcacttag cctcaaataa tggaattaat accttcactc aacaactcac accaggga 11220 
           tgaaggagag agatagtagc caaaaagata aaagaagaaa ctaaaaaaga actttgactt 11280 
           aagaggaaaa aaaggttcaa cttaagcaca cacccgtgtt ccaaaatgaa atcaagccca 11340 
           gaactcgtat ttaaataaaa atagcataga cgtttcaaaa atgtgaatat tctctacttc 11400 
           tctacctcag acagggggagt gtgtacatag tgtagagagt atatttcact aagagaatta 11460 
           ccatgtattt tattgatgca cttaaaaatg aaggcgatag acatgaatac cttgttaaaa 11520 
           agcaaggtaa agatatattt catatgttca attttctatt atcaattcct agtctgctca 11580 
           taatgccatt ttggggtggg gagcaaaggg catctgattc aaaatcaaac taatctcaat 11640 
           ttttgataaa atctaaggaa ttttattttt aaaacattga attaaagcaa actttggata 11700 
           ctctgatttc tcttgaggtc ataaatcctc tgccttttta agagatctat gtggagagga 11760 
           acaactctgg gtcttaaacg aattattgag gtcttgtttt ggaaaggcta gatattttgt 11820 
           taaaaaatat aagatttcaa aaaacctaaa actttggaca atgttattta atcatcaaaa 11880 
           gcaaaacaat atgcatattt cagaaataac actatatttt cagtcttact attatgcata 11940 
           agaaagaaca atataaaaat aatgtaatga ttacatttat tgtttacata ctctgaggag 12000 
           tatttaattg catcctagta agtatattct gtcacatgag aagccataga aattggcatg 12060 
           ttctgctgta tccaatgccc aaaggataat aaagcatgat aaaattacac ttaacgaacc 12120 
           caacctcctt ttccaattat atatggttaa gttaaaattc aaactttaat ttttgggaaa 12180 
           gttagttat ggcttagatc taaggtagaa ataaaatgac caaaggactt ggtgcattta 12240 
           acattctata actttagaaa tgcatcaaag tggcaagccc agcattaaga gctatttgtc 12300 
           actaagggcc tgtggttgaa gtctgttgga tccatctgtt ctttctgagg caatatgcag 12360 
           acgaaaggta aggggagttg caacataatt tgtaatattt gatacattat aatacatgat 12420 
           aaattataat atattagaaa tataatttat agcattacat ctagtaagat agatgtaaaa 12480 
           gggaacaggt aagtgaaagg gcaaggcata agtcttgtat agagtgacag gtctggtaca 12540 
           gtcctactac caaatctata actatagtat tttgaatatt ttgcactatt tcaatgtagc 12600 
           agtattttag gtttggttgg cctgacttta caacaagata aaaaattcca agttttaaca 12660 
           atgtagtgac ctactgtgtt ttagatgttg aaatctataa ttttctatca aattttcta 12720 
           ctaacctgta aaagacatgc cttagaatgt gggaacacac acaaacacat acatactcac 12780 
           agacacatac acacgaagta cagtagacca ctgatgatct ctggtgccac ttcctgagat 12840 
           cattttgaat gttctaatta aaaagtgcaa agtataattt tttgtcataa attatacatg 12900 
           ctatgctatt atatatgcta agccaaacct agcaacaagg ctgagtgaag atgtggctcc 12960 
           tgggtcatat gctaggcttt ctttcggcaa atggacttgc tctccctcag ttatgttaca 13020 
           tacctactca gatcaggtct cagcaaatgt acaaattact atgtcatcag ccatctggat 13080 
           cacttgggaa tagtcacatt ggtgaacgct gtaagtcata tcttaaatac attatacata 13140 
           atccatacct acagattgag aatgcaaatc tattttaatt aaatgatacc tttagagaac 13200 
           ccagtcttac acataaataa catatatta gaagccattt atgctctact ttgtttatct 13260 
           tttgtttaga ggcagggtct tgccctattg cccaggctgt aatgcagtga tacaatcata 13320 
           gctcactgta gtctccaact cctgggccca agtgatcctc cagcctcagc ctcccaaata 13380 
           gctgggacta taggcttaca ccaccatgct cggctattta aatttttttt ttttatagag 13440 
           atgaagtttc attatgttgc ccaggctggt ctcaaactcc tggactcaag tgatcctcct 13500 
           gcgtcagcct ccgaaagtgc tgggattaca ggcatgagcc actgcacctg agccgtgctc 13560 
           tactttggat aatctgttac tatcttactg attttcttgt cttttgccct tctagctgtt 13620 
           tctttagtct tggcaatcac cttagagaga gagaaaaaga gaaaagatga aataaaaaca 13680 
           atttatttca gtttttaaag gtttggcagt ggaggagaga gtaaagctaa tatattaaat 13740 
           atatttgggg ttattttggg gagctattta ctagttttat ctctgaattc aggtttaaat 13800 
           acattcaacc ataaattaaa aaataattgg tggataaatc aggaattggt gcaaaatcat 13860 
           ttttaagaag aaaatgtcat tatatagcaa agaggtagta tgctgcttta aatccttatt 13920 
           ttccttggca agcctaacaa gcagggcagt gcctgctgta tttatggtag tgccatataa 13980 
           ttagctgact cacctaataa gacttcacag cgcagcaaca actgccagct ttttttgtcc 14040 
           tgttacttgg atagactcgg ttgaatatac taatgcacaa agggaaatct gggaataaac 14100 
           tatttttact tttcatgtct aagggctgat cctcctcttc tagaaataaa atttattatg 14160 
           tatgttaaac tatattcaaa tttgtttact attttaagct ttcatggatt agaatcttga 14220 
           aggtcagccc cttgggtcaagct gactgaataa gacattaacg atgtgaagat gggtcaagct 14280 
           gagaaaggtt tgctcttgtg ctgagctcag aatcaataag tcatttcatg tttgcaaata 14340 
           caatgatatt tggaggcagg tctttttttttttttttttttttttttttttttgagacag 14400 
           agtctcgctc tgtcgcccag gctggagtgc agtggcgcga tctcagctca ctgcaagctc 14460 
           tgcctcacgg gatcacgcca ttctcctgct tcagcctccc gagtagctgg gactacaggc 14520 
           gctcaccacc acgcctggct aatttttttg taattttagt agagacagggg tttcactgtg 14580 
           ttagccagga tggtctcgat ctcctgacct cgtgatccac ctaccttggc ctcccaaagt 14640 
           gctgggatta caggcgtgag ccactgcgcc cggccagagg caggtcttaa aactagcaac 14700 
           tgggtgagaa atcagtgggg agggtaggct ttgacaaagt aagagataaa gagtctgctt 14760 
           tcatatttta gaaaaaccca gggaatgctg aaaagcccat aggaaagaag aaatatgctg 14820 
           tcaagatgtt agtgagccaa ggcccaggag tttgctctca aaaacagatg agaaactgga 14880 
           cttaaaatct gactgggaga aagtacttta ggcaaaacaa actactcata tacaaaagga 14940 
           tgggctctga agcagagagt gaaggcaata gcttcaagat cggtggattt aaaacctaga 15000 
           agtatcttct ctaaaagata aaagattaag aaaggcttta agatagctag agcaggaata 15060 
           aagtagtcaa gtgaatgtga taccacaagg ttccagaagt ttccatacta atagaaacag 15120 
           atactaagtg aagtttgagg ggccctcaca atctggatag aaaactcttc aagtagatct 15180 
           caaccttcag gctggaatat ctttgcttag ctatcccagc cagaggacca tagtggttga 15240 
           tttcaaaagg agttgcaatt attctatctt gtaaattctc tcattgttaa gttttgtcac 15300 
           agtttgttgt tgctactttc tttcagttac ctagaaaatg ttttctctga aaacctctat 15360 
           ccatgcctca acagatcgga gataaaaaag gaatcatctt acaagattat caagaaagat 15420 
           aatgggctag gtgtatccctt aaaaggtcat tcaaatgaaa tattaaaatt cttacttttc 15480 
           tgtgttattc ggacatggaa taacaataac agttaatgtt tatttggtgc ttactctgta 15540 
           tttggtacca tttcaagagt tttatatgca ttatttgatc ttaaaaaaca actctttgag 15600 
           gaagttacta ctgtctccat tttatcagtg aatgaacaga gataggaagt ctggctccaa 15660 
           agcccacact cttaactatt atgcaatatt agttgtcaaa tgtcttgaaa aaaaaatctg 15720 
           tgtaattact aaaatattac gctgggctac ttattaaggt aaaattacgt ttcaaaaaaa 15780 
           ttaatccttt ccaaatgcaa tgttaactat tcatgatgaa atatcagaac tatctctaat 15840 
           accaatattt ttatggaat aaaataggag gttaaaggaa atgtttatat atataaatgt 15900 
           gtgtatatat atgtatatac atatatatat actatgcaca cacacacata catatctatg 15960 
           tgtatatata tgattttttg caagggcaaa aaccagattt tttttaaaca cataatcatt 16020 
           aaatctgcaa atatcaagtt tatcaatttt ttgttacagg aaaaaatagt ttattataaa 16080 
           ttcaatgcat agcattttct ggtttagacc tttccattat tgttctgaca gaacaaagac 16140 
           tatgaggttg tcagaaataa attgttcatt ttgtttccta aatatgtggc aaagacattg 16200 
           tatgtttttt gtttgtttgc ttgtttgttt gttttagaat agtttgaaat gtcttcaaac 16260 
           cttttgacca accaagaaag cttttgcctg ggcacaggct ttatctttct tagcattaca 16320 
           ctagagatac taatccctcc caacaatttc attatgatta tcgcaataaa atataacgat 16380 
           ccattaagtc catggggcag atgtttattt atttataacc atgccttat ccacagagaa 16440 
           tttaaagagg aataaaagat tatttcctca ttgcatcaaa tgaatatctt ttattttgtc 16500 
           taatgttgta tttctttttc tttaattggc actaaatgtt tatttgcatt cttttaatta 16560 
           cttttaaggc atccattatt tctggattac attackgaac tctcaataaa tcaatacata 16620 
           gttctgtata taattttttc aacatttttt ccttctttaa tttggttcat ttgtatctcc 16680 
           ctttgctgtt tattgagtag aaattctgat ttttgtagca aagggagaac aaacaaacaa 16740 
           cacacagaat attctgtatt taatgctgca attgtctcta tggttgcaat gtgtaggtgg 16800 
           ggtgcattca agtgggcttg tggtatttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt 16860 
           gttggaagaa tatatattga ggatgattcc taattttatc actttgttga ggaactgaaa 16920 
           ttgtggctac aattcactc taaatatttt gtctcacagt cccctccctt caacaattat 16980 
           atacagtaca ctatttgttg gaagctcagg agaaaaaggg catttaagag catgagattt 17040 
           ggtggcagac tgacctaata gtagatggta ccagtgagat cttgagcaac gtaaatgttt 17100 
           caactgaaaa acggtaacaa taaaacattt ttcagagtga tgttgtacta aatgaaatga 17160 
           tatacataaa gtagcctata atgacccatg cacagtcata atatcaaata tttactgagc 17220 
           atctactatg tgctagatta ttttaagcac ttttgaaaat ataagtattt tgataaatgt 17280 
           atatcatata ttgtcttaat aagattatat tgttgttata tttcatctta ttgctaattt 17340 
           tattttttta agaaaacctt tttttggaaa gaatcgaaac taaaaaccca actatttaaa 17400 
           aaatggaaac ttttggccgg gaacggaggc tcacacctat aatctcagca ctttgggagg 17460 
           ccgaatgggc ggatcacaag gtcaagagat tgagaccatc ctggccaacg tggtgaaact 17520 
           ccgtctctac taaaaataca aaagttagct gggcatggtg gcacatgcct gtagtcccag 17580 
           ctactcggga ggctgaggca gaagaatcgc tggaacccag gaggcggagg ttgcagtgag 17640 
           ccgagacagc accactgcac tccagactgg cgacagagtg agactccatc taaaaaaaaa 17700 
           aaaaaggaac cttttgcctt acttcgtttg ctagctacat tcaagtctgc aattaagctc 17760 
           ggtgttttgc ctttctcaaa ctgtgcacag gtcctcttgtttgttcccct tctctctgtt 17820 
           gcctaggaat acagccaaaa acttgagtaa tagatgatag atgggtctgt cactaagcac 17880 
           atcctagtga catagataag aagcaaatgc tacaaaatta taggtgcaaa ctacaagttg 17940 
           tgttttaatt ggttttaaca agtacttata agcagaagaa ctgtgaaaaa tctaacattt 18000 
           tgtcctactt gcaagcctgc cagtcttttg agtgctgggc aaagacacaa tagtgctggg 18060 
           tcagagacaa ttaactttac tactcacatt aatagcatta gcaagagtat catgattttc 18120 
           ttgcactgat tcctcaagcc gcaattccca cagaaaagct caggtgacac ctacatgctc 18180 
           agtgggttgc attagaaaag aggaacgcag agctcaggaa acatggatat tttataatgg 18240 
           ccagtaaaga tgtccctttg ctttagaaag aggcactacc tctatccaag gctgcaagca 18300 
           cacctgcctt ttgttttaga aggagaaatg attctatct tccaaggctg ttcactatat 18360 
           gaaaagacag tcccaaacaa aaggcagtta ctgacttgct tgaaaaatgt gcagaaatga 18420 
           tacgctgctt gaatgtggac agctgacaca gggacaagga gtaaaaatga ttaggttttg 18480 
           agcttgacca actaggaaga taattattag cagtagagaa aaaaagaaca aagtagattt 18540 
           tagggcagat aagccatttt ttaggtaggt tgagtctgag atgcctccat aaatataagt 18600 
           tgaaaatatg agattggagt tgagacttca gaaatacata ttttgagtag ttacactaca 18660 
           gaggtaagtc atcagagttc ataaaattaa agtgagaaaa agaggcaagt gaagaaaaac 18720 
           aagatggcat tgcatgaaga actttcttag gaaggaaggc agcaaagagg taaaattgga 18780 
           ggtgtagtca gagatggaag atgaaaaagg aaaataacaa tatttcagaa atgaaatgaa 18840 
           aaaggtcttt tactaagtaa ttggtactac tacttgtcag tttcaagtgc tgtaaaaaaa 18900 
           atgggaagaa ccacacatgt gcactttcag tactatgtat tttatgcttc agggatgcat 18960 
           acctgtttaa caaaagtatg ttttttctca aagtgtgttg aatagtccag aaaaagatgg 19020 
           aggtagaagt cagacttcag gagataaagg aaccagaaag atcattgaag gctgtgatgg 19080 
           tagaaaacat tttgacaaag agttgtgcaa tgagaaagct aggggtggga caattaattt 19140 
           tgagggtaac aattggggat ttgagtagat tttttgcttc tgttctttaa ttgttttgtc 19200 
           ttctttttaa agaaaccaag agactgttaa tgtagtagga gcagagtttc acaatacaga 19260 
           gcagagagggg tgttggttga taaagaattg tctcaaatga gaggaaaaga atggagccaa 19320 
           taacagagat gatgtttaat ttgggaaagg tgggacatgt taacatgagt ccagagaact 19380 
           aaaatgagct tatggcatgc agatgctgaa gatgaagaaa ggaaaggaag gaaaaggagg 19440 
           aatttatatt tattattga ataatcttgt aaaactgtta atcacccctt tttactgacg 19500 
           ataagacata aatgtcagag gtgttttgcc taaagtaaaa aattcgatag tcaagctggg 19560 
           tttaaaacca tatcagtctt acgtcaaagc atgttttaat tgctgttgtg tggttgtgat 19620 
           tttaagggaa gaagaagagt tttataatgg gttctctgaa aaataaaata tcaattagaa 19680 
           agaaacaaaa caactgctga gaagcagtga atccaagcag aatctgagta tcatcacttt 19740 
           ttagttaaac taaccagtcc aatatcctga tttttcttta acaggcaaag aatttttgag 19800 
           tctttcccat agactgagtt cttgtgaact attttacagc aataatggca tccaatccta 19860 
           tagataacaa taacaaagct gcagaccatt ttgttgccag gtttctcctc cagggtggct 19920 
           ttccagctag tttgtaaaca aataactcag gtggccctgt catgttacat taactaaaaa 19980 
           ccaagtctaa agcacacata taataacata tgtgtgtgca aactggcttg ctttcaaatt 20040 
           cctaaatcat acaattaaat tttaaaaata actgtatttg gaaacaagaa aaaagtcact 20100 
           ttgacaccca actgatgtat ataaaggaga ctgtgcatat gggttttaaa atgagatgaa 20160 
           aattgaaatt tgatctttga gattaaaaac aatgttatgt aaatctattt ttattaatt 20220 
           tttctgaaaa atattgtatt tgctttatac cctcttgcta tacaaactta tattgttttg 20280 
           cttaccctct ttttttattc ctcctacttt ttcttaattt tgatatctct gaatttaaag 20340 
           tctagagaat gattcatctt cactagttct atcttttcca gtgctagtat ttttgttttt 20400 
           gagctgtggt ttccctatcc catttttgag atctcaaact ataatttggt gtcgagtacc 20460 
           caggtatctt atctttaaag tgaagacgta ggcagcacaa aggtgctttt attagaacgt 20520 
           ccactagatc agaatgacca gtgcacaaaa tttattttcc tagcagactc accaaattta 20580 
           acctggaaga gaatgtctga ctctgttgaa ttttcttagg caaatacaat atttgaaagt 20640 
           cactgaatgt ttcaaacaaa atataacaac attcagataa cagaactgtg ttaattgttct 20700 
           catgtgttta tgcccagaaa ataagcagac tggagcttct ctaagattaa aagtcaaaac 20760 
           agtattacaa ttccagccca gatttgacta tctaatcatt taaaccttag tatcatcatc 20820 
           atcaccaccg tcactgcata ctcattaagt taaaaaaaat tcctttaaaa taaatggaaa 20880 
           agaaaatatc tgtgtaaata gattaaagcg attcctgctc accactccct ttctccctgg 20940 
           ggcaggagac ttgagcacat caaaggaact catagcgttc ttggagtaag tgtgaaagcc 21000 
           accgtgatga actaaatgaa tgcttacatc taaagaaaga tgtaaacata ttacattaaa 21060 
           aggtggcatg acataatggt atatcactga ttaagaaatg tgaggcgact ttcatgtgcc 21120 
           actgataaat cattataatt tgacatagta gataatgccc ctatatttca tctgcatacc 21180 
           tggaaaatga ggactttcaa aacatattcc tgccagttac agtcaggtat tgcaaaacaa 21240 
           gcatttagtg agcatctaaa ctgaagctta gaacttcagt tttgtggcgg ggcgcggtgg 21300 
           ctcacgcctg taatcccagc accttgggag gccaagacag gcggatcact tgaggtcagg 21360 
           agtttgggac cagcctggcc cacatggtga aaccccatct ctactaaaaa tacaaaaatt 21420 
           agccaggcat ggttgcacgc acctgtagtc ccagttactc aggtggctga ggcagaagaa 21480 
           tcgcttgaac ctgggtggtg gagattgcag tgagctgaga tcctgccact gcactccagc 21540 
           ctgggcaaga gagtgagact ccatctcaaa aaaataaaga actccaattttattttcttc 21600 
           atggcatagc ataatagatg agttaacaaa ttaatgaaac agattgacat gtgttaattg 21660 
           caatcatata cagaacagaa atcatttcca taaaatattt aacctgcctg ttacttcccc 21720 
           taaatctctc tgtagctgat gccccaattt cactattagc tcttcagact tggatgttaa 21780 
           gcactgtgcc ttcccctgga cctctcttta aatgtcacag ctatttctgg caggtaagac 21840 
           tattgctttg gttagtgtga acacacacca ctgtggatca caaggcacct gagagaaaag 21900 
           gctgccgaaa gcaggaaaat aactcagaaa aaagaaaaaa aaacacatgg tgctgaaaaa 21960 
           tacaacagat atgcatttgt atacttatga tctaatttat gtcagtcatt aaaagaaaat 22020 
           aaggtgttta gaaaatacag tgctgtctat ggttatattt aatattgtga ccacttaata 22080 
           caaagcaaag cattcttgct tgctctcatg gagagtgcaa tttagaattg agagctcaat 22140 
           ttctaaggag ggtttatgta ctctatcttg aggcacacca aggagattga gtttaccagt 22200 
           ttagaaagca ctgccataat tcaagtcagg gagagggctg atggaagatt tttaaaagat 22260 
           tttaaaagat catgagggca agctggcttt taacaaaaca aaatatttcc atgtggcttc 22320 
           tggctgactg aattaataag gcccagagac tgatctgaag gcaaaagcct ttatttttta 22380 
           ttgcaatgga gaaaaactga aattatttg actatcagtt gtgaagttta gtaaaaagat 22440 
           tttcactaat gggtggtttt aatatttatg aatgtgatgg ttcagcaaat tttctccaat 22500 
           gttttgcaag accactaatt aataatcatc tttacaaatg gaacatgtaa ttgtctgcta 22560 
           ctattttttc tttgccaatg cttaatactt attttgaata cgttttattt tttttctaaa 22620 
           tttctctatt tatttctacc tgagcatttc ttaatttttt tattcagtcc tgttattctc 22680 
           actgtaggat ttttaaaagc tggtatatta tattaaaatc cttca actgt gaattcagca 22740 
           atgttttgag ttccagggat tcatctggca ttaggctgac cttgtcaagc ataaacatca 22800 
           acattaaaga aaatatttaa gaaatgaaag gcctgaatca aaataagagg tcaaattttc 22860 
           cagggtgttt tgtgtcttga aaatctttct gctgtaatta cctaaagact gtggttagat 22920 
           aattattgag ggacttttgc aattgtccct tttctctata tagatcacca cattaattaa 22980 
           acgagagtct cactgggaac aggttgctgt tctgcatctt taagtatttt tagtacttta 23040 
           ttttcaaaag agaaaaagaa cactaagaa gaagattgct tctcagccaa attttctgat 23100 
           atacagatat tctcaaaaga caagcacaca caacacacgca cacacacaca cacacacaca 23160 
           cacacacacc ccccaaggct ctggaatgtg ccttaacaat cttatttttg cacattttaa 23220 
           aaggaggtca ttatgaaatt tgcacatatt ttatgacctg taatgtactt ctctgatctg 23280 
           atttcacttg agctaataaa aaaatacaaa tcaggtgctt gctgtgatca agatgctaaa 23340 
           gttatatta cactgcttca taaatgtaag gtgttaaagc ttagtgagac aagaagtaaa 23400 
           ctgataattg attaaccagg gtgctataca aatctaccta gagggtgcct tcccaggtta 23460 
           atgcaattat gggagaaaga tcctggctcc tggctacaga aatgccaact aaagtgttat 23520 
           ccacccccatc cttcactttg gaggatgcgt taagatgaca ctgtgctgtg tcaaaatgaa 23580 
           aatacaaaca aaagcaaata aaccgagtga taataaataa accgagtgac tcagtttcct 23640 
           tatccatttt ccagttacct tttttttttt aggccagtct gcatgtccac tagaagaaaa 23700 
           gggacctggg ttcttcatca gcccatcctt agatcttagt gcacatatgc acctagtaag 23760 
           tgccgagcaa atattcaatg aatgactgta cctttcctaa gaattcttcg ttgattatcc 23820 
           ttcaacagag ctaacttctc tccctatgtg ctcagtcaaa tgctctccca ttggactgag 23880 
           ttcagcataa actgccatgt tttgagatga ttggtgtaag cgaatgtcct ctcctgagtt 23940 
           gcgagaatct aagagcagga caacatcaca tgcttctcta ctttctatag ttcttttgtc 24000 
           cactgtctaa caaataatgc caagtgaaaa agggaaaaat gaatgaataa attttgtaag 24060 
           atgccaatgg aaaaaaacag aaaatcaaga gttactaaaa aaaaccacta actccatta 24120 
           attgttttag actaagaatc cctcagtgat acctagccaa aattaggatt cagatccaaa 24180 
           ataaaagata ctgttgcccc aagtagatat cataatttgt tacaataagt aaaaatgtat 24240 
           attattcaat actaaactgt tataccacat ttcaagtttt taaaacttta tcttcctttt 24300 
           atgcatagat agtagtagag cattaagaac atgcatggct atcacctgag gtgttgattg 24360 
           taaattcaca ttcctaggct ttgtctctta actactgaat cggaatcttt gggagtgaac 24420 
           tgacaggaat ctgaatttta aaaataaggt cttcaggtga ttctcatgca tctaaagata 24480 
           actgctttaa tatataacaa agaaacccaa agagggacac ttgaggattt tttcaatata 24540 
           tcttcttttg cagagattaa tagtgaatgt tgttttatct gctgtttaga attttacata 24600 
           tgcattggat gatacatctt cttttactga caaaaaggct tttctctgga gaaaataaaa 24660 
           aggcagcttt ccctgagagc acacacttct agcaaagccc caatccatat gactctaaga 24720 
           cagagtgatt tccaccttct agtccttact ttcttgcaaa aggggctttc aaatctcatt 24780 
           actgatggtc ccatctttta ttactggtgt tatcaatggt atgcttgcag cagcttaagt 24840 
           atgtggataa agaaggaatg cacaatatac ggtactgaat atttttaaaa agtggtcttt 24900 
           cagaatgtct gtatgtgtgg gggcccatgc ttaggcatat gtgcatgcca gtgtgttatt 24960 
           tatgttgaaa ccaatgtttt acattaatgg ctggaattcc agaaaaataa gaaaatattt 25020 
           gtattttcta aaccattaaa agtttagtgg aactcattaa tagtctgtat catctctctg 25080 
           tatatttcag aagtacattt taagtgtaac agctaggggt aaactttcat aactgtatga 25140 
           tttgaacaca agtacaagaa atattcaagg ttttcttttc ttttttttttttagatgaag 25200 
           tctcactctt atcgccgtag ctatagtgca atggcgctgt ctcagctcac tgcaacctcc 25260 
           gcctcctagg ttaaagcaat tctcctgcct cagcctccgt agtagctggg attacaggat 25320 
           cctgccacca cacccactaa tttttgtatt tttggtagag aatgggtttc accatgttgg 25380 
           acaggctggt catgaactcc tgacctcagt cgatccaccc gccttggcct cccaaagtgc 25440 
           tggattacag gtgtccaccg cgcctggcca atattcaagt ttacacagga aaaagaatac 25500 
           tttctctgca taacctttac ttatttactc ataagcctct agttctctct ggatttgact 25560 
           gtaaatctca aacacatttcc cagaaactaa catcttctgg ctgacttcta ttaaaaattc 25620 
           agacaaagaa aaaaactgaa tacaatggag agagattata atactgctat tctcccattc 25680 
           tctctctcta cagcatatca cctcctccaa aatcagttca tatctaactc ctagcacatt 25740 
           tttagttaaa aatatacatg cacaaaatat atgtgtaaat acacatgctg atatcacaca 25800 
           tatgtgtgtg tgtgtgtgtgta tatatatata cacaaaagca gatatatata tatatatata 25860 
           tatacacaaa agcagatata tatatatgct ttcttgcagg tgatagaatg cttttttgga 25920 
           ggtggttttg tgggcctatg taatgtctct attgttatat tttaaaagtt tcttttttgt 25980 
           ttgtttgttt gtttgagatg gagtctccct ctgtagccca ggctggagtg cagtggcagg 26040 
           atctcggctc actgcaacct ctgcctcccg ggttcaagtg actctcgtgc ctcagcctcc 26100 
           agagtagcca ggattacagg cgcatgccac cacatcccac ttttttttttttttgtattt 26160 
           ttagtagaga caaggtttca ccatgttggc cagggtggtc tcaaactact gatctcaagt 26220 
           aattggccag ccttggcgtc ccaaagtgca agactgcagg cttgagccac cacgctccac 26280 
           caaaagtttc ttagcactca ttctcatgag aaaaattgct gaaaacttgg caataaagaa 26340 
           acagaatgac tacatgtcct ttaaatgtta tttttaaggg gctcaatcaa tgactatgaa 26400 
           gttatctaag ataaaacacc agattttgac attgccatta acttttttat tagagccccc 26460 
           agatctacag gttatatgtg cagatgtgca gtggctgctt tattccctt ttcaagagct 26520 
           tttcttatac agcatctatc cactctccta tagagatgaa gttaactccc ttgacaacta 26580 
           tcacttgtcc ccaatcccca cccttccact tgacatacaa acccaaagag attcatgctc 26640 
           atttatgctc agtagaaaac ataattccat aggttactgc tattattaat caaatattta 26700 
           ctagattt atctattagt caattctctt tagaatttct ttgactgttt ctataaatct 26760 
           ttattcctca gatattcctt taaaccagtc ttaccagctt attggctcca ctactaatta 26820 
           attagttgaa taaaatcttt gaaatgtgtt tatgtttgta taaaaaccat cttctttact 26880 
           tttcaaaaac tatacttgag cacactgtga aaagataaat tgctaggttc aactgaggaa 26940 
           ctgaataatt ttttcctctt ttagttttaa cattctacac aatctaaatt attttaaaac 27000 
           tcagaaaatg ctttaagctc atatttatag acttcccaag tagtacaatc tgttaactga 27060 
           ggtaggtaag taaacgtcct tgaaaacttc cataaatgat ggtgaataaa ttaaaaaggt 27120 
           ggaaacaatt ttccaggtct ctgagccata ttcaatataa tgaatcctga ataggagttc 27180 
           aatgaaaaga ttaggtagat tttttttaaa aaaaacccat atcccatggg atcctgctgt 27240 
           aaggtacttt tataaattat actgattata ctgtctcatt tctctgtcta tttgccatgt 27300 
           gttatatact ttggtgatct ttgagaaagc atttaaccta ttacaggcat ttttttcccc 27360 
           taaagtacaa gtaggtaggt caaaagaaca gcaaggacaa tgtctatcca cccaatctgg 27420 
           tggcctccga aggacaaaag ccagagttaa tctaaagcaa tcaaggagtc tgaccaccat 27480 
           ggaagccctg aggaagtggc tgctgtattt cccttttcaa gagcttttcg tatacagcgt 27540 
           ctatccactc tcctatagag atgaagttaa ctccctagac aactatcacc tgtccccaat 27600 
           ccccaccccct ccacttgaca tacaaaccca aagagattaa ttaacatttg ttccaggaag 27660 
           agacacagac aaaaacatcc gatattggaa tattccttcg tgaataaata taaaacttat 27720 
           ggagaggggag gaagatattt tgaaaggaaa aaaatcattg gactttatg ctcaaagcca 27780 
           aaagaaattg ttttttgtgg caaaagtaaa acaaggtaat tttgtactgt gtgctgtatt 27840 
           tctggcaatt atctgttatc ttaagaggct tatatagaaa gaacaattgt acctactttc 27900 
           acagcatgct ctgaggatct aaggaccctc aacaaatagt tttcatgcta caagcaggca 27960 
           cttatttagg cacaaatagg atgggattct ttttttaact gtagtataaa taattttata 28020 
           taatacagtt atataggctt ttttaaacaa aatacagtca gattttaaat ctctctattc 28080 
           taagatagac acttcacaat ttaaattcaa gactccttgt ttcttgaaga catctatgaa 28140 
           agcaaatgtt tttgagaact tggctgaatc tgagtccatt ccgattagca gattccacat 28200 
           tcacttttga gccatgactt agaagctatc aagacattat gtagcaacct ttttctcagt 28260 
           attccaggaa aataaaaatg tgcatgcatt aactcaatag gtattcagat gtttcccatt 28320 
           agtaagttgt gaccatgcaa taaaaaccat gctcaccaat attccccaat aaacttcaag 28380 
           atttgtaagc tcatgcatac ccacatttat gttaaaattt gaaataatga aatatttttg 28440 
           cattgtgaaa aatagatata tatgcatttt gtgaccaaaa ccatcaccac agttccattg 28500 
           ctgttgttgt tcttcttctt atttattatta ttaattatttt tggtttgttt gtatctggca 28560 
           catttggggt tataaatcac aaataacata aataagataa tgttaatctc cttcttacaa 28620 
           aatccaatgg cttcccacaa gtctatatat aatatgcaaa tttcttacta tagcttataa 28680 
           gatctggaat aatttttcct atctccagcc ttcacctctt ctcacattca tcatattcta 28740 
           gctaatcagg actcttttat gtcataaaat atgctagatt tgcacaccct taaagccttc 28800 
           atatacgagt ttgttctgcc ttggatacct ctgttccaca ttcccgaaca ttctctctct 28860 
           catcacacag ctggaccctt tcaccctcct gatctcaatt gaaatgtgac cttcctgtat 28920 
           aaactttcca tgagctggct tgtctgactg aacccaaatg gctaatggat tttctttccc 28980 
           gttacatgct ctctaattta tgatgctttg cttgggggga aaatgagagg tgggagtctg 29040 
           tttacggaac atggaagtcc ttttgcagag gtacaagagt ggaaatggct gttccccagc 29100 
           ctggctctct ggtcagacc tgacatccac agagagagca ctgcagtaac tgcaaacgct 29160 
           tctgttttga ttgtggtaat tggaacaatc agggcacaaa ctgcaaggtc actggcaagg 29220 
           gtagcagcag gcatgattcc tcccttagta attttaaagc agcagatttc aaaagggaaa 29280 
           accaagcaga tgaaagtgag cagatttgtt cttcagcaca tgtgagatac ccttggagat 29340 
           gccaataaat cactggagag actgtgaagg aggcttaggc cctgcagatg aagttagtga 29400 
           tggagggaaa tcgtgtttat cctcgggctg tcaggtctga aatacctggg ttaagtaaat 29460 
           ggcctctggg atggtcacag tcggcaatta ttagcagtta cagatccatc tctatgccaa 29520 
           aacagataac agcatccagg aattatccaa agtcacaaat cagtgtcagt gtcttgtcac 29580 
           tcacccacgt agtgcttttc ccttcctcct agttacttaa tggataaggg cacattgtca 29640 
           aataaacaaa caagtgagga taaatgttgc tccgaaattt aaggtgaatc attagtcaga 29700 
           cttggtatcg tcatggaatt tggtctgttt tctaactagc tttattttag cacagccata 29760 
           aatctggctg taattgtctt taactccgat gactcataca tctaagcatt tcatttaact 29820 
           ttcaaccgtg aaaaattcca actgatttgg caatatgaat gtgctcttac atgcatatga 29880 
           tcatatgatg ctgtcagtac aacatctgtt tttgttcttg ggatgttgat ggactatcat 29940 
           gaaccatctt ataactttcc cagtccccctt taagtccaag aggatacaac tgagaaggca 30000 
           ggtagagttt ttggtcagtg gctaggtttt tcctgaatat caaacaaatt gcctggtatg 30060 
           agaatttaac agaatatgac cacaattttt ttaacagatt tatctacttg aaacatcgcc 30120 
           tcagtcaatg aagaaactta tgttctataa ctaataataa aagatcattt gtaactgaaa 30180 
           tatgacaaat tgctgtttta atcatgagga ttaccatta gaacagctag gtaaacattt 30240 
           actttttaat ccggaaataa gttaaagcaa ataataaaaa tttatattta aatcacacaa 30300 
           catgttttat catgaataat aaatgttttt aaagtttaaa aatgtacttg ttaccttgtg 30360 
           ggtattcctg aacatgatta ggatttttat ttctccaagt attttattc actcacagaa 30420 
           tcaaaatgtc aaggctatat aagttttcat caagtgctaa tttagcatct aagtttttat 30480 
           taattaattt gtaaaggaaa taataatgag agtcaaagga agaagcatct cctgtggtga 30540 
           gctccatttc cagattccaa cgaaaccatt aaaatatta tggcactgag gctgaatcag 30600 
           acgggtcttg tgtactctct tgtgtggcca tattgtgtag caacagtggg tttcgaataa 30660 
           taagattcag tcatccatt agactccaat tggagctcag gcaacttcaa tttgtgatta 30720 
           taatgattaa cttcaaaaag atgcactatt tgtagaccta tgttgaaact tatgcagtgg 30780 
           aactaaaaag ccacctattt ttataataaa aaggcacaaa tacgcaaatg caaaagaaat 30840 
           tcattggaaa atcttgaacg tttcaaatat aattatcaca aatgcaaata taaaataaca 30900 
           atatgtttgt taatattata ctttcattta atcagttctt ctaagtaagg caaatatatg 30960 
           aattttttaa tatacaaaaa taccccccca aaactccat aagtatatct atatgaccat 31020 
           tgggtaagat tttttatgat tattattatg ggaaaattgt gactgtttag atatattaaa 31080 
           tatattaagt aatatatta atgatttaag attgttaaat aatttatatt aaaattgaaa 31140 
           cctcattttg ccagtattaa aaatttcaaa atttaaatac atatgacacc aatgcataca 31200 
           atgttacttt gtcctgaaca taagttttaa aagaatttaa gtttaaatat tctcctaaat 31260 
           gctttgtgag acttaagata aaaaacagtt cctcagaact cctgacaaag gggggcagta 31320 
           aagaagcaaa aagattttta tggagttcag ggaaagctga aaggcctttg tgtacattcc 31380 
           ctattttcta aacagtaaat gatggattgc attttaggca gactacaaaa ttgctaaaat 31440 
           taaatgttgg gatggaaatg tggaatgcag agtttgcaac ccccttttaa tttaatattt 31500 
           tcaaagaatt aagagaaatt attatatttt attttataaa atattatatt taaaattact 31560 
           caattctaaa tgaatgttat tgcaaaccta ggcttataag aagaatgcat ttagaagccc 31620 
           tagataacat acaatataaa aataatattt gcaaattatg catttgtttt cttttctttc 31680 
           tttttttttttttttttgag atggagtttc gctcatgttg cctagctag aatacagtgg 31740 
           cacaatctcg gctcactgca accaccgcct cctgggttca aacgattctt ctgcctcagc 31800 
           ctccccagta gttgggatta caggtatgtg ccaccatgcc cggctaattt tgtattttta 31860 
           gtagagatgg agtttctcca tgttggtcaa gctggtcttg aactcccgac ctcaggtgat 31920 
           ccacccgcct tggcctccca aagtgctggg attacaggcc tgagccaccg cgcctggcct 31980 
           gttttcattt taagtgtagt tgtctagcat tttcaataca ttcccccccg tttgacaaat 32040 
           tttatcttgc catttagcta atgggcaagc aaaaaattaa gtggaataat tggacagaac 32100 
           aattatctgg taacctaaac aatggtaaca tgagataggt attttatgca ttgtttggac 32160 
           ttataaacta tctagtgttc taataataga cataatggtt tattcaacta atagctactg 32220 
           tcatccttag aggttattaa caactcaaag tagtgaatta catccaacta aagggtgctt 32280 
           ttgtatagac atttgttctt attgctggtc acttattctt caaatatctt ttaggcacca 32340 
           tttacaaaga tgaccagagg tacaaaatct gcatatataa tagaaagagc caggtagtca 32400 
           ttcaataaaa gaaggtatat agtaccagga aaagattttt atcttagcct aaggcagtct 32460 
           gaattctcaa gcccaaagca cataaatttg ttggaattat ttcaatttct agtcactaaa 32520 
           aatgtgacgc acatttacac cagtggttcg gttgattact tctcttcagc cctagtctct 32580 
           taagcacagg tatacacact tacagcaata tctctgcata caatattttt gacagaatga 32640 
           aaaagttaaa aatattgatg tttatttcag cgattctgaa atggtttata aaaattctat 32700 
           gactataaga aattcatgag gaatgcaata tatcaggaaa gaacaatgtc atctttacat 32760 
           aaaaaggatg cgtgtcagta atttgagagg ctggaatcta gtgacaaatg tgtcactttt 32820 
           taaggtgtgc ttgattcaca gctgacagct ttgatttgaa attgccttta aaacaatgtc 32880 
           tatgtatcag tgcaatgaat tctaaccaaa agcttgttgg agctaaccac agtacctata 32940 
           tattcaagat gttcatggga ggaatggaag atttgatatt taggcactga agggttgcta 33000 
           tgatagttat tatacacaat tgagtttaaa atgaatatat gtgtcagttc tattattaaa 33060 
           tgttataaaa tatgagggaa taataaatgc tatgtaattt ataaactaca agaaaattta 33120 
           tatcaggaaa ctgcttattt cctaatatat gcactgtctt cagtgtctcc aaaactgtca 33180 
           actctgccaa tgtgactagc agatgatgag caggcagtcc gtgtgatatt atcaattaca 33240 
           tagtcagaaa tctgagtctt tctttcacct tatgagctgt ttaggaagaa ggtgtatatg 33300 
           tgtgtaacag ggagcaagag gagattaact tgtaagccat tatctgatgc aaaggcagac 33360 
           atttactaag tcatctgtga agagatggtt cgataatagc taagcattca tataaatctt 33420 
           cagggactcg aattctctca agtgtgacag aatactcctc tcaactgcca gcgctcctgt 33480 
           tgtaaaaaat cacatttggc aaagggctct ggtgttttga gttctgctca gtgacaggtt 33540 
           tgttttaagt aagattaata ctgaggacaa taaaatgacc ttcaattaag actcctttta 33600 
           aattttgtct acctgatttc cactatggtt cgtgtctagc tgtactctat ctaagaatga 33660 
           tctttaaaac attcaggatt atgagagaga tatctaggaa gtcataggaa ataaccacta 33720 
           ttcaatgctg ttctgtacac cattagtaaa ccataagaga ggacaaacat ttatccaaga 33780 
           aagagactat tacatagcca ccaggaccca atatggattc agcacaattg agcaatacat 33840 
           gtaacagatt tgtggtgaaa aacaggtgct gctcaattgc ttagtctaaa attctccctc 33900 
           aattccttcc catcacctaa tttgtttgac atctagtctt tttacattat aatatagtat 33960 
           attaaaaagt tcttattatg gttttttttt ttgagatggg gtctcgctct gtcgttcagg 34020 
           ctggagagta ggctcagtgc aaactctgcc tcctgggttc atgccattct cctgcctcag 34080 
           cctcccgagt agctgggact acaggatccc gccaccaacgt ctgggccaat tttttgtatt 34140 
           tttagtaaag actgggtttc atggtgttag ctaggatggt ctcgatctcc tgacctcatg 34200 
           atttgcccac cttggcctcc caaaatgctg agattacagg tgtgagccac cgcgcctggc 34260 
           ccttattata gaatttttgg gcatacattg cacatttttc taattgtgct tcaataatac 34320 
           caaacaagtg ggcaaatgct tcactgggct aatttgcat ccctgagtac aatttcacat 34380 
           tggttttggt tttgtgaatt ttggaggaat ttattttgag agatgcccct ggaaataaat 34440 
           aatgctgatg ttttggtgta attttattta ttgcattaat ggaatatgta aatacaatct 34500 
           atcagcatta ggcagaaaat atttaagaga tatcaaattc ttttgccgag aaaggtagta 34560 
           gtttgccagg aactacaagc tttctaactg aacttttaaa aataaatttt aatttttaat 34620 
           tttgatagat catcatagtt gcacatattt aagggctatc tgtgatattt tcatacaata 34680 
           ctgccatgtt tactgccact attcacaata gccacgatat ggaatcaacc tttgttcatc 34740 
           aacagaagag gagacaaacc tgactttggt ctgtgctggc tgcaggttct ggagagctgt 34800 
           ttgaagtgac aagatggcaa atgaaagggt cagttggttg cctggtggat tattcgtcct 34860 
           cataacactt tacctagaaa ttttgccttt tctcacaaaa ccataataat ggacaaacag 34920 
           catgaaccta gatatgcacc cccagtcact atcgtaaggt caagttggta tgagtcacat 34980 
           aagtagagga ctagaagttt tatctgaata gtattgtcat agtggctagg aatgagagtg 35040 
           aaaagtagac tagatgtgtg ctttgatatg gcttggagca aaaggtcagg tattggggca 35100 
           cttctgaaat gatatctatt atttaggaac tgggtcagga aaatctataa ttacattcct 35160 
           actgtattta cataccattc attcctaaga gagctcttcc aaaaaaaaaaaaaaagagat 35220 
           gtcagtgcat aaaaaataaa ctccatttct ttctcaagcc caaagtacat aaatcttgaa 35280 
           attttccagc taaaaaatag gcatatgttc tagcatcagc tttaatttat cccacattca 35340 
           ttctctgcta caataaagtg acaaagccat tcatatttta tgttacatct aattatctgt 35400 
           ttttcagtta gataaatatg ctttatatcc taggtaccat cagaatttca aagctcagaa 35460 
           aatcactaat gagaatggaa ggaattaacc atcatgcaag cagaagcatg cggctaccat 35520 
           gctacattgc tcagagttca tgtagcagtt taatcagggt agcagctgtg caatgagctt 35580 
           tgttggaact ggagtctcgc atcctaaatg tgaaatatct actgtttgaa agggtgataa 35640 
           ctttatgcct tgcaaagaaa acagtcctca agtgttattt tttaatgaat taacccttta 35700 
           tctttcctca caccttttct cttctttttttttttttttttgccctcaga agtatttaaa 35760 
           ggataatccc atatgataac tcacactgcc tagcttcagt acaatgtctc atacattgca 35820 
           ggcactcaca aacatttgtt taatgaatga ataagtgaaa gtccaatgga aaattacact 35880 
           gttgaattta caatggtttt agaggtacat ctctaaattt gttgaatttat ttaggattgt 35940 
           acattgtcac attttcactg ctaaatttca tattattcat taaagaaagg cagtgttgga 36000 
           gagttttata gttgacagat gaattatcta taacttctaa tatactcaga catcatgttt 36060 
           ttctagcatg taacttttaa aatataaact ctccaacatt taaagtttta acacttttta 36120 
           gtaatttttt aagaaatgac agatcaatag tagctttcca taaataaaag cctattaatt 36180 
           tgtataacat aacaaaattc agtgcaacat aaattcatat agtactccta caagaaatct 36240 
           ataggagtaa aattatgatt ataaaaatca acagacttaa acaaacaaat aacagctttc 36300 
           aattaagttt atagatacca aagacattca acctttaaca tcccactgtg taaaatcaaa 36360 
           tgggaaagga taaaaggacc aaagctatgg ttagtaatat aattgattgc tgccctacct 36420 
           acaaactaat ttgttttaat atctgtgcta gaaccagtat gttacccctt ttaactttag 36480 
           ctaaataatg tttatacaaa ccttactatg cagagctatc tttaacaaga gcatcccatt 36540 
           gaggaaaaaa gaaaatagaa agatatgaaa attttcactt ttttctaata ccaacagata 36600 
           tcactttat gatattgcat ttctgtatat aatgacatag aatatgagca ttccctgtag 36660 
           ttcagtttta ctgacagtaa cattgcacaa atcattttag ggctatgtgc tatgcagaga 36720 
           cattgtacag ttaattggca tcattaagta acattttgaa atgatgaggt gttcaaatgt 36780 
           agtagttaaa ggcttgattg gacattgcta aattgggtac tagatctcta aagagatgga 36840 
           atttaccccc tagtaggctt tatccttttt cacttgtctc agatttggaa ctcatttctt 36900 
           ttaggttgaa aattttatgt tcatgttgga aacttaaatt ttaacaatta aaagattact 36960 
           tgaaatgcaa tgctacccac ggctgcctgt cattttggga gtttcttata gattcttttt 37020 
           agggataaga attatgttaa aaccagatgc tagaattgct ttaattttta ttccccagtt 37080 
           tctcatttcc attttgacaa agaggcccaa aacatgaata gccttttgat ctgttttttt 37140 
           ctcccatatc agttcccatg agaccagtga cttcattctt tctgttattg caggtttaca 37200 
           ttttgcagtc atcttttatt cttgtatcac tatcttcaat cattgtggcc aattctttcc 37260 
           aggtcattct caaacctcca tatcaaagct atagatcaat aactatcaga acaagttaaa 37320 
           cattaagata aagttaatca tcttttcttt ataataataa ccaccactga attgcaattg 37380 
           ttatgaggta ttatgctaaa cactttatca aatcttatga aataggggta atttttattc 37440 
           tcatctcaca tgagaacttg aggcacataa aaattaaggc attttgcccc aggtctcatg 37500 
           gctggcaagt ggtctgtctg acagtagaga gccagcttca agcactgtac tatagggcca 37560 
           ctgtgtcatg actataaacc tttcatggca tggtctatac atttgggctc ttcagcttca 37620 
           aatttatcta tcatgcaggc atgacactag gttttcactt gcactggaag tcaactgctg 37680 
           gaaaattagt ctgtagaaaa ccgtaggcca cagagttcct gaatgtgtta gtaagaggct 37740 
           tagattttat tttggatggg ctgggaaata attgaagggt tgtaacaggg aatgtgcaga 37800 
           attgcattgt ggagagatct aattggagat tgggggaaag atgagcaggc cctaaactgt 37860 
           gataatgttg gcaagcttga aggggagggac agaatcagaa aatatttgta agtgacattt 37920 
           ctaggcccct gtgattact ggctggagga tgagcaggtg agaggtgttt gttttgaaaa 37980 
           aagtgatttt gaagagaggt cagaaaaaga ttttcatttttttacttcat gtgttcatga 38040 
           gttggggagt cagggtacag aaggaaagac acatgaagcc agggactgac acagagacca 38100 
           gacacacagt gggtgcttca tggatagctg ttgaatgatt tgtgaaaatc agatagcagt 38160 
           ggtgagggtt tttatgcaag tgaaatacaa atgaacttct caaggtgcca tatctgagtt 38220 
           gtggctttga tctggttcct gactttgaat tattttgttc ctatgaagta caggactttg 38280 
           taataaaaat ccaccataca caaaatcccc tggacttaag aatatctcca caagttataa 38340 
           gaattgaaac tgcttagaag gaacaattgc ttgtactcag ccagtcatcc tcagctgcat 38400 
           gagtctcaaa acgggggtgg agagtgtcta cctcctccag aaaaggtttt tagagcgaaa 38460 
           tcaaagagac tgcctcttct ccaccaaaat tatttgtctt aagatgggga caagaaacct 38520 
           ggcacccagg agtaaggaca cagacgtgct ctctcatttt aagctgaagc tgaactgtct 38580 
           tgtcctaaaa acatatgccc agactctaga aaagctctct tagacagact gctaatttct 38640 
           ccatttctgt cacttaagag gattttaggg acatataact ttgagaattc cattctgcag 38700 
           ctttcagagg taatacaatc caatactcat agtgggctta tggtgtaccc ggcacttttc 38760 
           caaacattct acttgttata gcttctttaa ttgaggtacg tattcttatc attctccatt 38820 
           tggggagattt gagagagagg caaagtatgt gccttaagat gacacagttg gtaagtagga 38880 
           aagcagaact ttaacatcag cagtaaaacc ctgagactat tgttttaatg tgtttaataa 38940 
           atgccccact aagaaaccag agcaaattaa aagtatgctg tgttctatta atttgataca 39000 
           ggcagaagaa atctaaaaac agcaaagaat gatattaag aagaactcta ttttaagtag 39060 
           ttataggaca tatgcttaaa ctgagtgaac tttttatgaa cttttcatca gagatttttt 39120 
           tttaattgtt gtttttctcc tgtgtctgtg actgaataaa tggcctctgt tcactggaat 39180 
           gcttcacatg cttcctctct cagttgtagg tgtgtttatt tctattcaga caccaaaggc 39240 
           ctatgggtat ctgcaaatta acagtttcat ttgctattat gttccatcat tgtgaagcag 39300 
           cacaggaaat taacatatct gtaaccacgc ccttactata taatatgaaa gtgtaaatta 39360 
           aaacatgccg tgttcattaa actgagataa aaccacattt tgaaaataaa gtttagtaag 39420 
           tggatactta gtatcacatt ggcgatacta agcttatgac ttgcttttaa tatttggatt 39480 
           gcaaataaat ttggaagcta atgtatggag tacaataata gcgaaaagca tgggctttga 39540 
           tattagacat ggctatgcat ccgaatatct tattattgga tattcgattc aagaacatat 39600 
           cagaatagta attatgttgt atttgattca gtggctgaga ttgaagggca actaaccaac 39660 
           agaggagaag atattattga ttgttctaaa gatttatcct ccaaagcttt cctttaccct 39720 
           atcttgttac atctttttta aacaatgcta attgtgtccc ttgtacatat tcttattcaa 39780 
           ctcctcagca aacatcttct atgtgaccaa cattctgaga ggtgctggag atgcagggaa 39840 
           gagtaagatg ctatgcttga cctgcagtat cttgaagcta gttggggcag caaaccatta 39900 
           agacattcag cagcatagct gttgtctgca gaaacagatg gggatccaag ggttggaaat 39960 
           aatacagagg agagatggat tcatttgaag agttctcttg ttgcatgctt aatataatta 40020 
           aagtgcctag ccactagtag atgacagttt tctaatttta cacatcatgt aatcccctta 40080 
           gtcttgaaga tattgatggt gttaatcact tgaatgcagt gacattaata atttcttaga 40140 
           taaaaagtat actgtttcca atcataaatt ccctgcctcc cagactctct gtgagcctca 40200 
           tgtgcataag tggagggaag gacctgctga tctaagaata cccctagtgt caaagaagta 40260 
           aatggtcaag taaggttgtc ctaagaagcc atgttacccc ttctgctggt gagcacagag 40320 
           cccaggtata aaattttttttttttttttttgagacagag tctcgctctg tcacccaggc 40380 
           tggagtgcag tggtgcaatc tcggctcacc gcaacctcca cctcccgggt tcaagcgatt 40440 
           ctcctgcctt agcctcccga gcagctggga ctacaagcac atgacaccac acctggctaa 40500 
           ttttttgtat ttttagtaga gatggggttt caccatgtta gccaggatag tctcgatctc 40560 
           ctgacctcat gatctgcccg cctcagcctc ccaaagtgct gggattacag gtgtgagcca 40620 
           ccacgcctgg ctgcagaatc tttacctagg ttactgttgt ccatgtgggt aacaatcttg 40680 
           acatctgaag tgttcattga ataaaaattt gtattgaata ttcttctaac aaaatctgaa 40740 
           aaaagtacag agctattttt gaaatggatg agaatgtatg gtaatttagc tagttcattg 40800 
           tatgtgtcct gttttcagtt atcattgcta ctgaattatt tatctttagg tgtataaatt 40860 
           atagtcaaga tgcttacaat tgatgaagga agaatgattt taaaacacag agcaaaatgt 40920 
           tattttaaat acagaagtct attcttctcc tccatgaata actggcattc tgtttctatt 40980 
           gtatattagg ttgaaatatg tgtttttgtc attaccagtg tttccacagg ataagactga 41040 
           aggcacaagc atttaatatt tgctgaaagc acttaaacag aaaaaatatt ggctagtgag 41100 
           attaagaatg aaataaggta gacaaatagc tggctgcaaa agagacctta aaaagtttct 41160 
           cagagcctgg ccaaaatggc aaaaccccat ctctactaag aatacaaaaa ttagtggggt 41220 
           gtggtaccat gcacctgtaa tctcagctac tcaagaggct gaggcaggag aattgcttga 41280 
           acccaggagg cagaggtagg ttgcagtgag ccaagatcat ggcactgtat tccagcctgg 41340 
           gcaatagagc aagactctgt ctcaaaaaaa gaaagtttat cagtctatta agaatatact 41400 
           tgatttttac aagaagaatc aattgcttta caaagttat tatctaaaat gtatgaataa 41460 
           aaatgtataa ctataaacat atctataaaa ctagtaaaga tcaaaagctc aggtatcttt 41520 
           aactttctct gcttctacta ttcacaaaaa tatttgctca gagacacaga aactcatctt 41580 
           caagatttat ttttatctgg gtggagttac agagttgcct tggtaacagc aactatcacc 41640 
           aaattaagtg ttaagcacac gtttttaaac atttttaaca ttttaaaaat gcagatgcca 41700 
           aaggagagca atgtcaggag agaatgttgt aaactccctt tttcccacat ctacttgaca 41760 
           ttacaaggtt tgtactactt tcagaaattc tccagtgttt aaaaaatgcg tctataaaca 41820 
           cacatataca cagagcactt cttattgaag taatcacctt aaaaattatg taatgcaatg 41880 
           aaaaccacaa tggttttcct accattgact aagaaagcaa aggacctttc ttctgaaagt 41940 
           gaggaggacc tcttgcctcc tgtcatttgt gaatagaact ctgtagtcag aaccagagca 42000 
           tttctggcat ttggtctaga atcattctga agggcaagcc tggtgctgtg ttgctaagca 42060 
           caaacaattt ggtatttggc tccaaaaata tgctcgagat tagttcttcc ctcagcaaca 42120 
           ggcgctcagc caaataattt ttaaccaact ctcagagccc agtattgctt gagctactga 42180 
           gatcctattt caagttattg ctatcaagat atggaggaga gtgaaatact gacacttgtg 42240 
           agatcccaag acttacacta aatccataca atttctgtcc tgaattaaaa atttttttaa 42300 
           aaaagagatg aaaagtgtga catttccaaa ccacgtaatt ggtttctttc accttaaact 42360 
           ccaagttaga gaagtatttt gttgttgttt gttttgtttt aaaactagac ttggtggaat 42420 
           acagaacata aacattttaa acaaaatatt aaacttctag aacagtggat cacttaaaat 42480 
           gaaaacttta agactttcct tagactgagt tttttattct taaaaaaaat taaaaggaag 42540 
           ttgaatttta tttctaaacg gtgcaggaca aatgaataaa atacattttg cctctgtctt 42600 
           aaacttagaa cagatacgca atctctttaa cagtatgtaa aaattcagtc ttttctttct 42660 
           ttggtttcca aattacagtg aaatgaaaca ttttcctttt atgtgtaatt agtgcagttt 42720 
           aactaagagt tatggagcat ctttccacct catggtgtat ccatgtagct gaatttcttc 42780 
           agcatttgct tttttaattt gtataaggag taactgttcc atatcttaga aatctttgaa 42840 
           attagaagtt gatctaatag catctctaat gtagtctctc cttgaatttt aaatataata 42900 
           gatatgacct gttatttaaa agatatagtg tttactggca tataacagtt gtgttgagaa 42960 
           tttttcattg aataaaatat atttcccttg aaatttttgt tttatggtca tatctcataa 43020 
           tccacctctg aatcaatgaa cacttgtatt ggtggagaaa acaaagatcc ttcagacaga 43080 
           ctttctgtgt ggtatgttct ttctgtttct tttctaataa cattaactta catttaaaat 43140 
           tattataatt cactctattt tcacaaatca tcaaatcata ctcagatatt taaaaataaa 43200 
           ttttattgta tatatttaca gtaaacaaca tgctgttata agatgaatgt atatggtgaa 43260 
           aaggttatta tagtgacaaa aattaacaca tccatgtct atctcacgta gttacccact 43320 
           ttttcccctg tggcaagagc agctataatc tactcaatta gcaaaaatcc tgaatacaat 43380 
           acactattac taactatagt tgtcatcctg catgtcagct ttttagttcc tcctacatat 43440 
           ctgctacttt gtatccttag atctacatct cccaatctcc tccctgccac ctcactcatg 43500 
           gtaaccagtg tgtggactgt gttttttgtttttttatttt gagacagagttttgctcttt 43560 
           tgcccaggct ggagtgaagt ggcgccatct cggctcactg caacctatgc ctcctgagtt 43620 
           caagtgattc tcctttctca actgcctgag tagctgggat tacaggcacc tgccactatg 43680 
           cccggctaat ttttgtactt ttagtagaaa caggatttca ccatgttggt caggctggtc 43740 
           ttgaactcct gacctcaggt gattcaccca cctcggcttc ccaaagggct aggattacag 43800 
           gcgtgagcta ccacatccgg ccggtaacca ctgttttat ctaactttat atttgaactt 43860 
           tttcttttta gattccacat ataagtgaga ttatgcaatt ttgtgtgtgg atgtgtgttg 43920 
           gacttatttc ccacagctta atatcctcca ggtccatgca tgttgtggca aatgacaggg 43980 
           tcttctcctt ttttaaggct gaataatatt ccattgtata tacatatacc acagtttctt 44040 
           ttatccattc atgcaccaac acatacctag gtggtttcca tatcttggct actgtaaata 44100 
           atgctgcaat gaatatagca gtgcagatat ctttatgagg tgatgatttt atttcctttg 44160 
           ggtacatcca gaggagggat tgctgggtct taggtaattc taattttaat ttctttagga 44220 
           acctccgtac tattgtccat aatgactgca ccaatctata tttccaccaa caatgtacaa 44280 
           gggttccctt ttctctacac acttatcaac acttaaactg aacatgtaga ctttttcttt 44340 
           tcattattct ctaaacaata tagtataaaa actatttca tagaatttac attgtattgg 44400 
           gcatttatcag taatctagag atttattaaa gcagcagtcc ccaacctttc tggcaccagg 44460 
           gactggtttt ctggaagaaa tgtttccacg gacagggatg gtgaggggaa ggggaatggt 44520 
           tttgggatga ttcaagcaca ttacatttat cattagattc tcataaggag cgcacaacct 44580 
           agatccctca catgtgcagt tcacaatagg gttcgtgctc ctatggcaat ctaatgccac 44640 
           cactgagctg acaggagggag gagctcagct cttgctgtgc agcctggtat cgaacagcct 44700 
           aacaggctat ggaccagtac tggtcatggc cctggggttg gggacccctg attgaaagta 44760 
           tatgagagga tgtgcatagg ttatatacaa atactaagcc attttataac aggggcttag 44820 
           gcatctgcag attttagtac ccaagggagg tcctgaaacc aatcccctat ggctactgaa 44880 
           ggacaactgt gtatcattct taacagaaaa aaacaaaatc tgttttgtaa ataaaatttt 44940 
           ttcatttatta tttccatttc actctggaat ttagttagaa attaagatta acaaaatatt 45000 
           aattgactac taaaatgtac cagcactagc agcacatacc aaaaactaat acaaatattc 45060 
           caataatatt aaataatgac tgcatttgta tttcatctga gagtggttta tggttcttcc 45120 
           ccataagtgg ctgattatt gatggccact ttttcttaac tcctggtctt tctcacaatc 45180 
           acagaaaaca gtcccttatc acacaaataa aaaagtcatc tcaccatcc tctgtacctt 45240 
           ttatcttaac agacttgtgt tttgaaatat tattatact attttttaat tttttgagac 45300 
           cgggtctttc tctgtcaccc agtctggagt gcagtgcgcg atcttggctc actgcagccc 45360 
           cagcttccgg gttcaagcaa ttctcctgct tcagtttctt gagtagctgg gattaccagc 45420 
           gcccatcacc accacccagct aatttctgta tttttagtag agatgggttt caccatgttg 45480 
           gctaggcttg tctctatccc ctgtcctcaa gtgatccctg caacttgacc tccaaaagtg 45540 
           ctgggattat aggcatgagc caccatgcct ggccttatt atattatatt aactctaata 45600 
           atcactatgc cactttctgt tgtaattctt taggcacttc ttctttgtat gtttttaatt 45660 
           agcatgtagt tatatagtta tatatttacg tttagatata cctccaagta gccaatattc 45720 
           tacatgaagt gataaaggat ttattattcc ctgaaattat gaaaagtctg ccttgttttt 45780 
           tctttcttgc attgtgctac agtacacaca tacacggaca cacgaatgca cacacatgca 45840 
           cactgggttc tgctaattat catttcctta gttccatatc attccccaac ccctaagcca 45900 
           cctgtgtcca taccagtctt cccactgcct accagcccca tgtcagatga cctccatcag 45960 
           tagtatctcc atttatggtg tctcgccttt ctgacacata gtaacaagtg aggtgttaag 46020 
           actaacaaga gaaagaaggc attattctta tctggctaga aagaaaacaa tcagcaactt 46080 
           gtcttttatt taagggaaga aggcttcact ctactatatt ttcaagatat tccaaaactg 46140 
           caacagaccc tttcaattat tttactttca tctattacca aaaaggccaa cttttagatt 46200 
           gaggcaatga aaactcagaa acttttttgg aatgaccttc agattgaga tgaccactgt 46260 
           ttcaacaata tttcagttat aattctttct ctatattcat ttagggaaat ttgattctga 46320 
           aaaatacaaa tagcttcctt tctcctgagc taggactgta tttagaaggg aataaattgt 46380 
           agattttatt aaaatttgat cacattttct ttttttgtgc tacgacacag tagcaatgta 46440 
           gattgaaggc ttttacatgt atttttaaaa ttgccataga gaattatttg tattaatcat 46500 
           agatttccaa ggctgcaaaa gctaaatagt aaagcatata ataatggtag cgttaatttg 46560 
           aaaaaaaatt ccagctagca aaacatgagt ctagatgtag atatcatgtt caaaaatcac 46620 
           aaagcagatt gccagcaaaa aattgaacca agtttttccc cttcagaaaa ctagctttat 46680 
           ttaaaaaaat ttcctaatat ttaaattgat tcacacgttt ataactatac aagggtttcc 46740 
           ttgtttcatc aaagaaataa gtatgaatga gcagaatgtt ttagtataaa agtttacaaa 46800 
           gtttattcac actcggaaca aaggaataag taggaaaaaa agagcaacta aaaacaaatg 46860 
           aattcttttc cccatccctc tcgtttgtct ccaatcagtt aaatcctttt aatgatatat 46920 
           cataagtagc ttcatgcttt agttcacatt gacgatattc ttatatctac atcattaata 46980 
           atcaaaatag tctttctgtc tttagttttg ctgtctctaa gtcagaactc aatactgttg 47040 
           ctctaaaata caaatgttaa gatgattctt caggagcttc tcatcacctg tactataatg 47100 
           cctactagcat gagagcaccc acctagcctt cttatctcaa gtcctgccct gccactctgt 47160 
           acatatatcc cctctttaat tcacccttag acagagacag agagggccac gcatcttgtc 47220 
           ttttcctgaa ttaatatgtg gtttttgccc catgctttag cacatgtgaa tccatttgtc 47280 
           cagcatgcct ttgctcacct gtgtacaaga agagctacat aacagatcaa aaggaacatc 47340 
           aaaggcgctg gttcttagag tctcatgtcc attcctccaa ttctcgccac ttctggatgc 47400 
           actgtttctt atgagcttcc ttaaatatgc tgtgcctttttgctttctgc gtatgggcat 47460 
           ctccagtgcc aaagtaagag gagatttctg cagaatttca ggaagttaat atcctagtgg 47520 
           cagctctcag acaatggggag acaggagcta atggctgttt cttcgttttg tccttcaggc 47580 
           tgataatcca gaaaaccaat ctgcacaatg cttgagaagg tgcagagaat tagagccctc 47640 
           attgccctca atgcagtacc tttatattgg ctttttctcc ttaattcatca catgctcctg 47700 
           tttcccgaga ttgccaccca catatactac ttgcacccta cactatattt caggctcttc 47760 
           cttcaggata atgaaaccaa gctaaaggca aaatccaact tttgtttaac tcatcctgct 47820 
           tctgagctcc caagatccct gaacctactt ctcttatata atttattata gaaagttatt 47880 
           taagcatgag atttctctag tttatctttg aatctccact gtcaatatag tctctggcca 47940 
           atgaaagctg ttcagttaat gtgtggtgat tcaatacatg cactcctaat tctcatttat 48000 
           gaacattttg ttaaatcgtg gcctatagga aataggcatg taaaatgcac ctgtaagttt 48060 
           tatagcacct agtacagagt gacagctcaa aactatttgc agaatgaaag aaaaaaggaa 48120 
           gttgactctc caaaacaata cacatggcca aagcctggaa aaaagtaata gtgtcccagt 48180 
           gtaacttcta ggaggtgtga ggaagaaaga aaaacaaaat tggcaccttt tcccaggctt 48240 
           tagactgaga gatattaact tggagagggg aaagcatagt ctaaagagaa acagggctaa 48300 
           ggaaggtatc actttctttt actatctctc aagacagattg caatgcaatc tcaaggcagc 48360 
           actacactgg acaaggtact aggactctga ccattcttgt ttttattctt tttttttttt 48420 
           ttgagacaga gtctcactat gtcacccagg ctggagcaca gtggcactat cttggctcac 48480 
           tgcaacctct gcctcccggg ttcaagtgat tctcctgcct cagcctccca agtagctggg 48540 
           aatacaggtg cctgtcacca cacctggcta tttttttttttgtattttttttgtaatttt 48600 
           tttttgtatt tttagtagag acagggtttc actatgttgg cctggctggt cttgaactcc 48660 
           taaccttgtg atccaccgc cttggcctcc cacaaagtgc tgggattaca ggcatgagcc 48720 
           accgggcccg gcccatattt ttattcttaa agaaccagaa ctatatgcat ctagtgttcc 48780 
           ccaagttttc ttctttgtct tttaacattc caggaaaaca gatattgagt gttttgctgg 48840 
           atcatgcata gttccatatc cttttgaccc tctgtttgct gtagccagct ttgattcttt 48900 
           ggattcatgg tcaccctata acatattcac taatccacca atgaaaggtt atgtaatgta 48960 
           taacaatcaa ctcagggttt tctaatgaca atctttatca atgttctata agcttgaaaa 49020 
           ttaatttaat aatttatacc attgtgcata aaatataata aaaactttaa tttaataacg 49080 
           aaattcatgc atacttttac aaacttatca gtcattcaga agtaaatgtg gacttcagtt 49140 
           ttgtgggcag gggtttacag aagtatgttt tactaaagtt tggagaaaag atcagtataa 49200 
           aaatatgaaa ttataccaat agcatttatta gaaatagtta aaagacaaag ttataagtatt 49260 
           ttcataatca tatcactttt taagtgacta aactactaaa gaaacattta gttaactcta 49320 
           aaatattgtt gtaaaatttc tatgtgtttt gaggaaaaat acttttattc catcataaaa 49380 
           ttttcaactt agagaaacaa tttgtttact tgaaaaatta taatattttc aagtaaaaat 49440 
           ggttatactg acaatttatt aaaacataaa taaaagttct tccccacactt tgacacatga 49500 
           ttagaaaaaa aaaggcagta agattttcat acagaattct ggggttaagt agaattcact 49560 
           tgtgtttgct ggtctaagat gcaatggaat ttggaggcaa tggggctgga ttctatcaaa 49620 
           tcagacacac ggaagaggtt ataacgtgag aatttatatt ttttcatttt ctcagcccac 49680 
           acttgaaata acaatttgca agagttttgc tttgctcaat attaggcctg attagctaaa 49740 
           atgctcaaat ttccattcaa tccttaaaaa cagatccaca cttagtcatt cttcacacct 49800 
           ctctccctcg ccctttcaca cccaaattgt taactttttt ctctattctc aatttatag 49860 
           tctggttcag acttccgtga tctgtcactt gctcttgtgg ttaaatttct gaagtgaaat 49920 
           tcctatctct aatctcttct cctatgtatg tcatcagact tgcaattttt tctaaaccca 49980 
           aaatgtgttt tcactagtcc cctgttaaaa aactgtcaac acatccacat tgcccactgg 50040 
           ctatagagtt caattcaaac tagagtcatt cactacttgg acaaccagct tcccagctcc 50100 
           acctctgggt attctttctc ttgccttcag aatggtgttg aggatataag gtgaatgcaa 50160 
           cagccattgc tctcagtgag ctcatagtct aagtgaggag acagatgagc agatcattat 50220 
           aaaacaaatt ggcaagtgca atgacagaag tgtgcatagg tgctatggga accaagagga 50280 
           aggatatata ataagccagg gaaggaagag aagattcagg gagacttact ggaggatgaa 50340 
           ttgccctcag aaagtattga agtgtaggta acagttggtt aagagaagca gaaagaagga 50400 
           aaaggagaca gcagcacagg gtgccaaaat aagaaaagcc tgggtaatac tgccaagaga 50460 
           aatctacaat taaatgcaat tcccatcaaa ataccaccat cattcttcac agaactagaa 50520 
           aaaacaatcc taaaattcat atggaaccaa aaaagagccc acatagccaa agcaagatta 50580 
           agcaaaaaga aaaatctgga ggcatcacat tacctgcttt caaactatac tataaggcca 50640 
           tagtcaccaa aacagcatgg cactggtata aaaataggca cacagaccaa taaaacagaa 50700 
           tagagaacct agaaataaac ccaaatgcta acagccaagt gatctttgac aaagcaaata 50760 
           aaaacataaa gtggggaaag gacatttgat gtattgtatg ggttacataa gatcgattaa 50820 
           gtggagatgg aaattttaca actttttgtt gtatattgta aactattttt aaatattagt 50880 
           ggcaaaaaga ctaatatgga taaatattcc caacaatttg atatttgatg tcccaaacta 50940 
           ttgtgagatt ggttataata aaaaatagca aactaccctg ctgatttccc atgaagctta 51000 
           accctctctc aatttcaga accagcctga cttaagcctc tacatactta aacagcttca 51060 
           aatgcctatc tgagacagct ttgtaatggg tctctgcccc tgtttctctg tccacaagag 51120 
           gtactaattc acttctcttc agttgttaga cctaggacac aatagacacc aagttacatt 51180 
           tctgttaggt gcatcttgga agtgcctgag aactgaccac tgggcaccta cctttttacc 51240 
           taagtctctg ttaatgttgg tctgtttacc tgttagtagt ggagcctggt gcatagaatt 51300 
           atctccttgc catctgtgtc ccacaacaca tatataaccc cctgcatggc atatgaggcc 51360 
           tttcctgaga ggggtgcttt taagccaaca ttccagagac ctagttcccc tgccccaggt 51420 
           gcctcagttt ttacacctag gatgctattt tgaatcttct cctcaatgac aagtatctgt 51480 
           actcacttag tttgggtcca tgccacattc ctgaggcaac tgaaacccac ctactccttg 51540 
           atggccttcc aggatgcttg tctgtactat agtggacatc ccttcctgcc tcacggatgt 51600 
           ccgtgtgtgt gtgtgtatgt ttggttttta ctggattcct gaggaaggcc ttccactgaa 51660 
           cttcattcat gtgctttgct acctgttaga aaatgtaacc taatgtaaat gtaaacctct 51720 
           ggtgcctcta gttttactga cttatgttat ataaatcttg gttcctggtt ctttctgttg 51780 
           ccctgttatg agatgtatca ctctaagcca agcccaaaca ctaagataac aagtgctaaa 51840 
           gatgacgaat attctgaaga gttttcagga cacacagaat tgtttgtggc cagcacctca 51900 
           gtaccaataa cagatatttc atgttatata gtggggtcat taaggactta tttgagggaa 51960 
           taatcaagaa aaacttccta gtcttgctag agatctagat atccaaatat aagaagcaca 52020 
           aagaacacct gggaaattca atgcaaaaag attaccacct gggcacacag ccatcaggtt 52080 
           gtctaaagtc aagatgaagg aaagaatctt aagagctgtg aggcaaaagc atcaggtatc 52140 
           ctataaaaga aaacatagca gattaatagc agatttctca gcataaaccc tgctagccag 52200 
           aagagattgg gccctatatt tagcctctta aacaaaataa ttatcagcca agaattttgt 52260 
           atccagtgaa actaagcttc ataaatgaaa gagagataaa gtctttttca gacaaacaaa 52320 
           tgctgaattt gccactacca agccagcact gagaaatgct aaaaggagct ctaaatcttg 52380 
           aaacagtaac ttgaatacat caaaatagaa cctccttaaa gcataaattt aacaggaccc 52440 
           ataaaataat aacacaatta acaacagcaa caacaagaag gtattgaggc aacaactatc 52500 
           atgatgaata gaacagtacc tcatacctca atactaatgt tgaatgtaaa tggcctaaat 52560 
           gctccactta aaagatacag aatggcagaa tggataaaaa tccatcaacc aagtatctgc 52620 
           tgtcttcaag agactcacct aacacgtaag gactcacata aacttaaggt aaaggggtgg 52680 
           aaaaagatat tccatgcaaa tggaaactca aagtgagaaa gaatagcaat tcttatatca 52740 
           gacaaaaaag attttaaagc aacaacaatt aaaaaagaca aagagagaca ttatataatg 52800 
           ataaaataat tagttcaaca ggaaaaattt acaatcttaa gtgtatatgc atctaacact 52860 
           tgggctccca aatttataaa gcaatcacta ctagacctaa gacatgagat agacagcaac 52920 
           acaataatag tgggggactt cagtactcca ctgacagcac tagacaggtc atcaagacag 52980 
           aaagtcaaca aagaaacatg gacttaaact ataccctaga acaaatggac ttaacagata 53040 
           tttacaaaaa atcctaccca acaactacat ccttttcatc aacacatgga atattctcca 53100 
           agacagacca tatgaacaag tctcaataaa tttaagaaaa tcaaaattat atcaagtatt 53160 
           ctctcagacc acagtggaat aaaattaaaa attaactcca aaagaaaccc tcaaaactat 53220 
           acaaatacat ggaaatcgaa taatctgctc ctgaatgatc tttgggtcaa caatgaaatc 53280 
           aagaaagatg aaaattttaa aaatatttga attcaacaat aataatgaca aaacctatca 53340 
           caacctctgg gatacagcaa aagccatgtt aagagcaaag ttcatagcat taaatatcta 53400 
           catcaaaaag tctgaaagag cacaaataga caatctgagc ttacaccctct aggaactgga 53460 
           aaaacaagac aaagcaaacc caaacccagc agaagaaaag aaataacaaa gatcagaata 53520 
           gaaataaata aaattgagtc ttagtgtggt ggctcacacc tgtaatcgca gcactttggg 53580 
           aggccaaggc aggcggatca ccataagtca ggagtttgag acctgcctgg ccaacatggt 53640 
           gaaacccccgt ctctactaaa aatacaaaaa ttagccaggt gtggtggcag gcacctgtag 53700 
           tcccagctac tcgggcagct gaggcaagag aatcacttga acctggaagg cagatgttgc 53760 
           agtgagccaa gatcatactg ttgcattcca gcctgggtaa caagagtgag actccatctc 53820 
           aaaaaataaa aataaaaata aataaataaa taaataaaat tgaaacacaa aatacaatac 53880 
           aaaagataaa tgaaacaaaa acctgcttct ttgaaaagat aaacaaaatc aatagaccat 53940 
           tggcaagatt aaccaagaaa acaagaaaaa agatctaaac aagctcaatt agaaatgaaa 54000 
           tgggagatac tacaactgat accacagaaa taaaaaagat tattcaagac tactgtgaac 54060 
           acatttacgt acacaaacta gaaaaccaag aagagatgga caaattcctg catatataca 54120 
           aacctcctag attaaaacag gaagaaatag aaattattaa cagaccaata atgcatagtg 54180 
           agagtgaaac aataatagaa aaaatgtcag gaaacaaaaa aagtctagga ccagatggat 54240 
           tcacaggtga atgctatcag aaattcaaag aaaaattggt acaaattcta ttgaaactgt 54300 
           tccaaaagat agagacagag ggaatcctcc ctaaatcatt ctatgaagcc agtattaccc 54360 
           taatatcaaa accagaaaag gacataacaa aaaaagaaaa ctacagacca atatccctga 54420 
           tgaacagaga tgtaaaaatc ctcaataaaa tactagctaa atgaatccag cagcatatca 54480 
           aaaagataat ccaccatgat caggtgggtt tcataccggg gatgcagggt tgctttaaca 54540 
           tatgcaagtc aataaatgtg atacaccata taagcaggag taaaaacaaa aatcatatga 54600 
           taaactcaat agatgcagaa aaagcatttg acaaaattca gtattgcttt atgattaaaa 54660 
           ccctcagcaa aactggcata taagatacac accttaaggt aataaaagcc acttatgaca 54720 
           aacccacagc caacattata ttgaacgggg gaaaatttga aagcattcc cccgagaact 54780 
           ggaataagac aagaatgcct gctttcacca cttctattca acatagtact ggaaatccta 54840 
           gccagagcaa tcagacaaga gaaagaaata aagagcatcc aaactgctaa agaggaagtc 54900 
           aaactgttgc tctttgccga tgatatgttt gtatacctag aaaacctaaa gactcatcca 54960 
           aaaagctcct agatctgata agttaattca gtaaagtttc cagatacaaa atcaatgtac 55020 
           acaaatcagt accagtgcta tacaccaaca gcaacaaaac tgagaatcaa attaagaact 55080 
           tgagcctttt tacaacagct gcaaaaaaaa aaaatgctta ggaatatacc taaccaaaga 55140 
           ggtggaagat ctctacagga aaactacaaa atattgctga aagaaatcac agacaacaga 55200 
           aactaatgaa aacacatccc ttatcatgg attggcagaa tcaatattgt gaaaatgagc 55260 
           acactgccaa aaacaatcta taaattcaat gcgactccca tcaaaatgcc accatcattc 55320 
           ttcaaagaac aagaaaaaaa atcttaaaat tcacatggaa caaaacaaca gcccatacag 55380 
           ccaaagcaag actaagcaaa aaataacaaa tctggaggca ctagattacc caacttcaaa 55440 
           ctatactaca agactatagt taggaaaaca gcatggtact actataaaaa tagacatgta 55500 
           gatcaatgga gcagaataga aaatccagaa ataaagctaa atacttacag ccaactgatc 55560 
           ttcaacaaag caaacaaaaa cataaggtgg ggaaaggaca tcctattcaa caaatggtgt 55620 
           tgggataatt ggcaagccac atgtagaaga atgaagctgg atcctcatct ctcaacttat 55680 
           acaaaaatcc actcaagatg gatcaaagac ttaaatctaa gacccaaaac cttaaaaatt 55740 
           atagaagata aacttggtaa aactcttcta gacactggct taagcaaaga gttcatgacc 55800 
           aagaaaccaa aagcaaatgc aacaacaaca aaaaagataa atagatggga cctaaaacta 55860 
           taaagcttct gcacagcaaa agaaataatc atcagagtaa acagacaacc cacagaatgg 55920 
           gagaaatatc tgcaaactat ccatctgaca aaggactaat atccagaatc tacaaggaac 55980 
           tcaaacaaat cagtaagaaa aaacaaataa tcctatcaaa aagtgggcta aggacatgaa 56040 
           tagacaattc tcaaaagaag atagacaaac agccaacaaa catatgaaaa aatgctcaac 56100 
           atctttaatg accagggaaa tgcaaatcaa aaccacaatg tgataccacc ttactcctgc 56160 
           aagaattgcc ataattaaaa aataaaaaaa taaacgttgg catggaagtg gtaaaaaggg 56220 
           aacatttttt tacactgctg gtaggaatgt aaactagtac aaccaccatg gaaaagttat 56280 
           ggagattcct taaagaacta aaagtagaac aatcatttgt tccagcgatc ccactcctag 56340 
           gtatctaccc agaggaaaag aagtcattat atgaaaaaga cacttgcaca tgcatgttta 56400 
           tagctgcaca attcacaatt gcaaaaatat ggaaccagcc taaataccca tcaaccaatg 56460 
           agtggataaa gaaaatgtga tatatttaca tatatatata aagcatagggg gggtgtgtgt 56520 
           ggatgctatg gaatactact cagccataaa aaggaacaaa ataatggcat ttgtagctac 56580 
           gtagagag ttggagacca ttattctaag tgaagtaact caggagtgga aaaccaaaca 56640 
           ttacatgttc tcatttataa ctgccaccta aactaaagga tgcaaaggca taagaatgat 56700 
           ataatggact ctggagactt gaggggaagg gtgggaggaa ggtgaggaat gaaagactac 56760 
           acattgggtg cagtgtatgc tgctcaggtt atgagtgtac caaaatctca gaaatcatac 56820 
           ctaaacaact tctccatata accaaaaacc acctgctccc caaaagctat tgaaataata 56880 
           ataataaagt taatcagaaa attattgtct ataacaccaa tatattattt ttattaatgc 56940 
           atttctttta atgtattgtt atttgtcatt aattaaatta gtagttacac tattaagcga 57000 
           tctgttgtta taattaatta attaacctcc ctttatcaat taaattataa agccctgaag 57060 
           gcaactgagt agaggcccaa taagtgattg ctgaattgaa atgctgaact gaattatact 57120 
           tcatttatata gaaagcctca tatatagggc ctcacatata cccttacaca aaatataaga 57180 
           atccactaca aatcacttca tcgattaatc aactggctgt actttgtaac aaggtttgca 57240 
           caaataaaat atctttcagg aaaagtgtaa aatatatttc attaatctgt gaaaatgcaa 57300 
           ctggaagttt tgtggcttcc tagtttgaac tccgcccaag aaggcaaaac ctttatagac 57360 
           ccatagtttc ccgtctaggt actgctcttt cacacatctc taagtctgac tagacacatt 57420 
           gtaacataag ctgtggtcac atgacaggta ggtgtctcag taacaggcaa caccagtcat 57480 
           ggaaaaacaa aactaagtgt ccaaatgagt gcagaatcct gattgcagct cacatttact 57540 
           cttaaacaag aggccctctt cttatattct caggtaagtg actctgtaat aagaggattg 57600 
           tgtagcattt acctaacagc tttactttag gactgtatac tgtccttaga tatttttaaa 57660 
           actttttata tttcatttct aaataagaat attacaaaaa atttcctaac atttatataa 57720 
           cataattctc aaagtagata gagccaaata actgacttct gctagttttt tttccagata 57780 
           tttgtctttt atgtacatgg ccagaaacca cttagaactt gcataaaaac aagttaagaa 57840 
           gcaaaatgtc agttagttcc tttctctatc ccagagcgca ctgtttcatt aggaattttt 57900 
           caataaaaat aataatgtag aaggtgtgat ttttacagtt ttcatgtctt gatatatagt 57960 
           gaaattgagc aatgtgagaa taaatgtgat ctagaaaaga aaaatatctt tcgatttgag 58020 
           aacagatggt taataataat catgacagtg attcaaggtt aatgacctac atgctaaact 58080 
           tgttttaatt tttaaaagcc attackaact gaaaactccc tgctttagct gaaccaacac 58140 
           ttaacaagtg ttttttaaag atgtcttgat accttcagag aagttctcct gctgctagtt 58200 
           ttctctggag caacagtggg aaaccccagg tggttactcc tttgtgaata taagcatcca 58260 
           catgaaattg gttgtttccg catgcacggg caaacatgtt ttgttatact aatgtctgaa 58320 
           gtacaaattg ttgtagaatc attttattcc atagacttcc aagtctaatt ctaatactaa 58380 
           cttccatcaa tagttaaatt attattatc ttctatccaa aggctacctg aaggtcctat 58440 
           cactttggtg tgagaagaat cgggtaagac aaaaagttag gcttgcacca gttatcaata 58500 
           gaatattaag aaagattttt aagaaggaga atagcagttc caggttccac atatttgata 58560 
           cttttcacca gaaaatagga aagacggatt gggtctgcaa tgtattttca aagtcaaact 58620 
           tctattcctc tatttaatgt attttacag agatgacttg agaaaacaca catttctttt 58680 
           gaatcttgat gtatatattt ttgacggatc agacactctt acttgagcta ggtgatctca 58740 
           catcattatc tgttgctatg tgctattgtt tctgtagcca aatgaatggg ccattggcaa 58800 
           tcaagccaaa caaattttgc ttttacaccc gattttagca ttaatctaca gacacggctt 58860 
           ttcaatagta gaaaagatat ctcccatttt agtccaaatt taagtatagt taaagctaca 58920 
           ttttgggaaa aatgttttat catttttttg ttcacttgtg ggatgaaaag taggattaaa 58980 
           cagtccatta tctctacctt ctctaactgc ctttactaaa attttaaaat atttcttttg 59040 
           aagaaacaaa acataatatt tgccattaaa tcttaaaagt atgacaacta aatggatgct 59100 
           aagacaattg tgtttcaact gtgggcttat aaactctatt gagaaactca tttatgatca 59160 
           tgagtttttt ccaggatgga catataaaga tggattttta aaacactggc ctggagaata 59220 
           gggagagaag aggtaataaa aaagtattta tattacttat atgagacata tctttttata 59280 
           atatctatat ttaaaacatt ttaaagtata aatatttctg tactataata caatatacag 59340 
           tattatagtt tatggtctgt gatttacggt aattactgtg ggtcattttt tctgaattaa 59400 
           ttttataagt gaacaagcaa agtgaccaag agaatgatct atgatccaga aataactttc 59460 
           aatgataaaa aacctgaagt acaacaaaga agtcagaggc agggctagac aaaatggaac 59520 
           taaatatact aagaaggtgc agaaaaagaa gagaagagta tgttgtggct taaccccata 59580 
           tttccccatg gcagaaggac agaaactaaa tctgagggca actcaacagt agtcaataat 59640 
           tatcagccaa atcaatggat gaataggtgg atggatgaat gcatggatga atgtttgtgc 59700 
           ctgggaaccc ttctgtcatc atgcataagc agcctgagtc ttagataata ctatatgaca 59760 
           tgctttcttc atgtgaataa acagacctaa agacaggcac taggagaccc tgggaccaca 59820 
           aagctcagat tgttataata aaaggaggga aacaaagctc cctgttgaag aaaatttttg 59880 
           cacacttgat atacaatatt tctactaatg aacagagaaa gcttgacttg aaaggacaca 59940 
           tttatattag atgtcatccc tatctagagg ccattactat caagcatctg tcaggtaaag 60000 
           gagatgagat gcctgtaatt ttttctttaa atattgtttt ttctaagttg tgttggaaat 60060 
           ggggagttgc aagtttgtat ttccattgct taaaaataga aaacagatga agaaaggaga 60120 
           tatcatcagc agaacataga agattcata atacggaggc taaaactctt aagaaaaagc 60180 
           aatatttatt ctagtgccca acctaccatg agaaagttgt gcgactttgg gcaagttat 60240 
           taattcctct gggtctgaag atgagtctgc acacaagagc ctataatgat cccttccaac 60300 
           accgggactg gcgggtctgc agccacagtt acatctggaa actccactgg tgcttttgga 60360 
           gcttcccaag agtatcagga attcaatatg cagtcataaa aaattttggg tcatgttctc 60420 
           taagtacaac actgccatgt gtgtgaagag atatctttat taaaattttt cttaagttgt 60480 
           tccttcctaa agtagtgaaa gctgagcaga tcttagaaat tcatttagaa ttcatattac 60540 
           tcaattacac ttgactataa cacttaagaa tctagttatttccttttgt agtaaaaata 60600 
           tattttattt gaaatatgtg aatggttatact tagtcatttt aatctacatg aaaaatttaa 60660 
           ccttaaagta actctatttt aaaaatatga aatgagacta tcaatcggta cttatgaagc 60720 
           aatgtttatt cttctaatat agtgtgggaa gagaaatgta aaagtcttgc aacacaaaag 60780 
           ggattgttct cacaaatcat aggtttgtga gatggggtgg caaaatctca ttgtttttaa 60840 
           agaaccaagc tgttcttcat gagcaagaac actgaattcc ctggttttct ttttctagtc 60900 
           actatacccc tggcatacata acactactgt caatcaactg catccagaag gtagaataaa 60960 
           atgccaagtg atactttcgg cagaattcca gagattctca gatggttttttcttttccct 61020 
           cttaaaaact gtaccatatg agttaggttt attttgaaat gtccatgaaa aagaagtcag 61080 
           atatttctta aaattggccc ctcttagata tttctgggga agcttcatat aattccattt 61140 
           gttcatgtta ttccttttca tcataaatca gtcctctata aagagcttca aattttcact 61200 
           gcctgatgct actgtaaaaa tatacctaat atgtttgatc gaaagacagt agtcaatata 61260 
           tttattagga gaaatacttt attcactaat cttaagaaat actagagga atccagtaca 61320 
           atctgaagtt aaaactaatg atttattaaat gaatgttacc attttattaa aaattaataa 61380 
           tagtaataaa aaactacaaa gtactttcac atttccattt gactctcaca ataactctgc 61440 
           ttttacacat aagcatatat acttacttac ctgtatacat gtacacatat tatgtataat 61500 
           aaccctctta ctatatgtaa gattcagaga gggtaaataa catgaataag accacaggac 61560 
           tcttaaatta tgtgctagtg attataattc ctacattatt tctataggat cagctggctt 61620 
           cactgatatc aaaagattat atatagttat ataattttat aaagttctgc taacttagtg 61680 
           actttatatg catttttcag gaaacttgca aaaacaagaa ggtgaataaa cttcgaaatg 61740 
           agaagagttc actaagcata atgcatttat tttgcatcag gatttttcaa cgttttaatt 61800 
           tttaattaaa aaattaaaca tttttaatag ccgacataca tctccaaaat ttacttctcc 61860 
           aatctttcca aaagaattga tgaaaatgta aaccaagatt tagatgtaag gatgatcatt 61920 
           ataacattat aagaagcaaa aattacagaa aaacattgta ttcaaaaaca ggtgttgatg 61980 
           aaggtattta ctttattcac aagtaaactg aaaccagaga gatcacatga tttggtcaca 62040 
           ggcacagcaa caggtaggag cagatctggg atccaaatcc atgttagcta tctccagaca 62100 
           tagatctctc tccaccaaaa cacacttcag accacactcc aactatggga ccaatggttt 62160 
           gccccattgt ttatgccta tggtaatggg tttatgtata atcgtgacta aaatcattat 62220 
           ccttttaaat tgaaagaaag atgggatggg tgggtaaata gattacagca gaaccaagca 62280 
           gtagattgct attttgccac acataccaaa tattagataa tgaacttcat attaaatatc 62340 
           ttctctaggt ctttatcttc atcatagctc acaatgttgt atgatgctct ggcagaaact 62400 
           aaaaactatg cttgtagaat gtctcattta tatgacaaca gaacgactga gtgaaatgga 62460 
           gcttaatatt aagtctgtta agaggttagg gacaagccaa aagacagagtg agactctgtc 62520 
           tcaaaaaaaa aaaaaaaaaa gtaactcaga gataaataaa agtaagttct gagctgacat 62580 
           ccataaatgc tttgtggcat tagatgctgc taagagtgaa ttatttccat gaagccaaga 62640 
           tcaagctgtt gcacaagctg tacattaatt acttgaaaaa aattcccagt agggcaatgt 62700 
           ctaaatatat ttccatgaga atagtatata tatttgttat aaaggtgatg atctagccaa 62760 
           gagggtgtct gacctccaaa atatatccac taataaaaaa aatccaagga gcatttggat 62820 
           aacagtggtt aaaaaaaatt gcaaaacaga tggacttcac attttgggca tgactacaca 62880 
           cgtggccaga tcaatcccag tgattcttcc atgcaaatat gttagtgtga ttagttgatt 62940 
           gtaggaaatg tggcatttgc attackaata tgttttgttc ttgtcatggt tgtaaaaaca 63000 
           gtctttactt agcaagtata aatgttagca agtataaata tgtttaaaca taaaaaataa 63060 
           gactaaacaa gaataaaaac tgtttttaac tataattatc aagtctacaa cccaaaagtc 63120 
           tttttcccat ccttgacaca ataacattca aacatgattt ttaatgatct cgtagtacat 63180 
           ttattgctaa attgtactca aaataatgtt tcattttact taagtggcac aagccccctg 63240 
           taggtatgat tacattccgc atactaattc ttcttgagct cactgacaga agtgactatg 63300 
           tcttcttata aaatttctat actcccatga tctagcttag tttcaaccaa ataaacggca 63360 
           ttcagtttat atttgctgaa gggaagataa tctccttcta gttagcatct atccaacacac 63420 
           agtgcttaat aacagattgt atcagagttt gctagttgtc caccaaaatc tgttctccct 63480 
           tctttgtcag ggcatatggc tatatactac aattttctgt ctaccttgaa taaattgtgg 63540 
           ctggtatcca aaggaatgag aaaggaaata atgtatgcta cttcgaagtg ggtatggatg 63600 
           catcccctca gaagacggtg gggctgcaac ttgggaggag tctgggttcc tcaatctccc 63660 
           taagggagaa actcacccac ctgccaaaaa cacctaccat ggacttatgt gaatgagaat 63720 
           caacctctac tgtgtttgag cattttaatt gacattcatt taacactatt taatatacag 63780 
           atgttcagta gatgttcact aaatgaatta agtttttgta gtttgatttt ctgaagaatt 63840 
           tgaaacagat caaatgtata gagaagtttc aagaacagtc aaagagtccc tctatccact 63900 
           tcacccagaa ttcctaattg ttaacatttt acctcatttg ctccctctgc ctaacacatg 63960 
           gatgtatttg tgcgtgtgtg tgagagtgtg tgtgtgtgtg tgtgtgcgtg tgtgtgcgta 64020 
           tctttttcca gcacaatggt gcattaaccc taagtacttc agtaagtacc tctctaaagc 64080 
           aaggattctc ttctacacta acactgtaaa actgtcacaa ccaggaagtc aacactgata 64140 
           gaacactgcc atccaagcca gaggatgatt aaattattat gtgcttattg ggtgctcaat 64200 
           tgggtgttca gcatgacaag tatcataacc accataatca tcctggcttt ctctttcatc 64260 
           caccatctct gtctctctct cttttccctc ctacttccta ggctgctggg cacactgcca 64320 
           ttgacctctg cttgacatct ccttcctccc cctgtcagca gccttgctca gacatcaacc 64380 
           accagtgttt gcatgtcccc atggcaagaa caagggggaa gggagtagga gggaaaatta 64440 
           gtaaggacaa gggaaggtgg atgaatgaat tcatttttaa tataatgcta cgtgaaaaga 64500 
           aatgccagaa agtaacattc tgaaaatcac tggtaaaagc atccccaaag tctacctgat 64560 
           atggacattt aaattcatta aaaattctga gtttaagaaa acagctaaga ggttgagaaa 64620 
           tcagagttgg ctgcccaact tacaattctc cttgctgacc agcatctttt ggctgcctct 64680 
           caaaataaca ggataaggca cacaaaactg aattcttcac ttggattaaa tctgaatctt 64740 
           ccttctctta ttcctttgct tataaaatat cttcctaggc ttgagacagt ctagagacca 64800 
           cctgagaaca ctgaatgttc cttttgagta tccagtagca taactcacac tgtcaacaag 64860 
           gccttactta cgtgtgctga aatttttat atttttgtat cctttatcac aaaccaaaca 64920 
           ctgcttagtt ataaaatata tgtgtaagtc aacataattt tttttgtcaa agcaaagatt 64980 
           tttctccaaa atatagctac agaagaaaag gggcttataa caagtgtata gtacacattc 65040 
           agaaacattt tgtttcatgg atgtttcagt aaatgcttca tttctatgta ggaggtataa 65100 
           gattcctgct aaaaatacat tcccttccct gaatattcac aatagcttgc caaaaattct 65160 
           cacaaatgaa taaagacaga actgattaac tgtattaagt gtcctactta atacaataat 65220 
           aattcaggtt ttaaataatt tcaacatcag ttcatttat taattaatct cataaaaacc 65280 
           tcccaattaa tgtactatgt ataaatttta tcaagtactt tgatgaatta agaggaaggt 65340 
           aaaggttttc atcaatatct gcaataatat tattaaattg ggctaaaagg aaccaagaca 65400 
           aatgaagata tataagaaaa ctaatcatta ttttagacta aaacaggaaa agaacatagt 65460 
           tatctaggac actgtctcct tagtttttaa tgtttcttcc ccagatgggt ttgcacatct 65520 
           tttgcctgaa aaaagaactt atttccacca cacaagttac attaaatacg tcttttagct 65580 
           cctagggagc tgaaaggcaa gtccaaaatg aactttttta ttcgttatgt catgaaacta 65640 
           taacactgca ttattaatac acctctaatc aataaagcct aaaaatccat tcccaagaga 65700 
           cccagatttc tctaccagtt ctagttgtac tagttatct cagcggtaag ttttcctagt 65760 
           tcttaatatt aaaatgagag gtccagaggc tctaggtggt ggaggggttg ctagctaaaa 65820 
           ggagggtgtc ctacagaaag ggacagagtc tccatgagca atgctggatg gtacctgtgg 65880 
           tccagttctt ggcacatggt gagtgctgcc taagtcttgg tgccctagac ctgcagcagc 65940 
           aatcggcggg gaaaggacca tgactttggt gacaaaagtg atggcagaag agtggaaaga 66000 
           ggtatgagtg atgactaagg acaaagaaac aagggtagaa ggacaattcc agcagcagcc 66060 
           tatccgaata acaaaatcct tatctcagga aaaccatctc tgctatgaat acatacacac 66120 
           acatatattc atcaggtatc aatttaatta ctgattggaa cactgtaaac ttgttcaaaa 66180 
           tagagggttat tatcagtat cttcagctgt ccggattcac cattttatag catgctctct 66240 
           gacattagtg agaatgaatt gtactctaca tattaggta atggtttggt atacagctgc 66300 
           tattaacgat ttgtgtgcta tgcaatattt gtggtctcct gtcacccacc tcaggagaca 66360 
           caactgatgt aagtgagaca gctcagcata tcctatggaa aaatctctta ttaaataaag 66420 
           gtcaatgatt aagtagtata gtcattgaat taatttgttt tccttaagag gagctctcct 66480 
           caggtcaaaa ttaaagtcag ggatagataa gtctctcata tggttccccc agtgtgagag 66540 
           gagcaagctg ttggtttcct ttggtggctt ttttcttgtc tcagaagaat aaattaataa 66600 
           attctgcata gctgtgattt tgtgtgacaa aaatgaagaa cctgtgcctc tgtttacaaa 66660 
           gcaatgcaat gggaatcacc tcccctggtg tctcttcccc atcaccacca ctttgcccgc 66720 
           tgaaatgttc ttaaccccac ccaccataaa aggtgatgat aaattgttgc ttcaaactca 66780 
           tgctgattga aattttccag ctatttttaa ataaccccca ctactggatt tcttgcttct 66840 
           atgttatatg acaatgcttc tttcaggtga aaatgtcctg gaaacaagta atttttacct 66900 
           ggctacctttttttttttttttttttttat aaagaaagaa gtttaattga ctcaccgttc 66960 
           tgcatagctg aggaggcctc aggaaactta caatcatagc agaaggggaa ggggaagcaa 67020 
           ggcacacctc acatggcagg agaaagagag agcaaaagga agtgccatga ttttaaacca 67080 
           ttagatctta tgagaactca ttcactatca tgagaacagc atggagaaac tacccccatg 67140 
           atccaatcac ctcccataag gtccctccct caacacatgg gggttacaat tcaagatgag 67200 
           attgggtgg ggacacaaag ccaaaccgta tcactatgga tggtagtatc agggtgcaca 67260 
           tgcatctttt tttttttctc tctgattttc tttttttatt taaattcttt ttttttaaat 67320 
           tatactttaa gttttagggt acatgtgcac attgtgcagg ttagttacat atgtatacat 67380 
           gtgacctggc tacctttaaa gatggatatt gactcctcca aaatgctttc acttgaaaaa 67440 
           aaaaagaaga aaaaaacctc aaaaatgaga agggctttcc gacttgagga aagcaaatct 67500 
           ttttaacttg cactaggaac atcacgacat tttcttgcct cttagatggt ttgtattttg 67560 
           gatgcttctg aagagaaaca aagacatata gaatttaaac attatctgtg tttatttgta 67620 
           gaatacttat tttttgtatt ttgtttttta aatgagtatg tctgatatct catacattta 67680 
           gaatatttgt aatagaatag caaatttcca ccatggaatc agtggagagc tatgcaattt 67740 
           aacaactgca aagaatctta gagatcctta gagtaacaca tcctcttatt tacaaatggg 67800 
           gaaacagggt atacgagtag aagtgacttg cctaatccat aagctagggg tacaacaggg 67860 
           tcattagggc catcctgttc aatttctccc tgatatgatc ctagcgatgg agtacctacc 67920 
           aactttcttt acaatagccc aacgtctagt atgagaatca ttctgtggac actcttccaa 67980 
           attgaaacaa tctccttgga ttactcctgg cacagcttat gtattctcat agccaatccc 68040 
           ctggtcatga ctctgacact agtagataaa aagtatcact ctaatctctt gatcttttca 68100 
           tcatgccttt atttttacac atgcagtact cagagtctaa acaaacctta gcttgcattt 68160 
           tcctcttaaa agccccaccat ggatctcaca gttttgttgt tgttgttgtt gttgttgttg 68220 
           ttgttgttgt tgttgttgtt gagacgggat ctcactctgt tgccaggctg gagtgcagtg 68280 
           gcacaatctt ggctcactgc aacctccgac tccttggttg ttcaagtgat tctcttgcct 68340 
           cagcctccca aatagctgag attacaggca cgcgccacca ggcccagcta atttttgtat 68400 
           ttttagtaga gacagcgttt caccatgttg gccaggatgg tctcgatctc ctgacctcgt 68460 
           gatccaccca cctcagcctt ccaaagtgct gggattatag gcgtgagcca ccgcgcccgg 68520 
           cctcttgtag tttttaaaat taaatttaat ccaataaaac atttagtttg cctttatttg 68580 
           gaatttgtta tctattgtta tatactctat taatacctcc tcttcagcaa ggaaattttc 68640 
           ttacatctgc ttacacgtac atcatttgtt agagccccta aatattggta atgatgatga 68700 
           tgatattata gcatgaatta ctttacgttg aacattggcc taagtgcttt aaacacatta 68760 
           tttgcctagc atttacaaca tttttgtagg tattatttgt cacaattaca ttttcttgtt 68820 
           ctatgatata atttgttttg atatcgtatt agttttctat tgttccccta ctgaattacc 68880 
           acaaatttat tacattgtgg gattgtaagt ctgaagtcca ataggggtct cactagccta 68940 
           aagttaaggt gtcggcagga ctgtgttctg ttttggagac tctaggagaa aatctgtctc 69000 
           cttgcctttt ccagcttctt gatgccattc atagcttctt tcatgatctg gcatcctata 69060 
           cgttatactt attttctgat tatattttgc ctaacctctg tgagatatta attatttgag 69120 
           ggcagagatt tttatttgtt tgttcataac tatatccagg tgccttaaaa tgatgcctga 69180 
           cacaaaatag gtactcaatc aacataggtt aataaatgaa tgagcaaaaa gttttattgt 69240 
           gcatattaat tgttacctgg gggaatatac tcagacatct taagtctcat atgtaaactt 69300 
           ggggtattga tatcaacatg ccattttgag gattaattga ggttatgtct ataaatacct 69360 
           actagcatag tgtctagcac atagtatgaa aacattgtat tattaaaatg 69420 
           gcattttgtt ttctttatag cacctgacac tatccaaatt gccttttctg tttcttttct 69480 
           ttttacttat ttcttaattg tttcacaaag gcagagtctt gtatgctttg cctctatgtc 69540 
           tttagtacct agaatagtgc ctgtttaaaa gtaggagctg aataaatgtt tgctgaatta 69600 
           atattaatca tgtgtaggaa aagaagcttg ggaatgttat tctaccaccc acagctgtgc 69660 
           ccactattat gatggttgtt ttgtgtgttc tttctcaagg attcactttc agaactcaaa 69720 
           atggggtgta gggtggtggt ggtgccagca gtggggatgg gagaagctcg atctctccct 69780 
           acagtagaag tgcttactgc tctatgtgtt cttcagccct ataagaacca atgaaagcca 69840 
           tccaacacttc cctcgatact ggacatccct acatactcac agcagtctgc aaaacatatc 69900 
           caagggccca ctgagacact gaagatgacc cattgatta atacatattt gcaaggctct 69960 
           gattgagaac ctctggacag gcgcttatct agaggttaca gtgtgtgact aacacgacac 70020 
           agtttaggat ttatgtaaca ggaatatgct atagggagag aaagaacaga agacctcagt 70080 
           tgacacggtg gaattggagt gagagagatt tccatgaagc caagtaaata gtattttgga 70140 
           gagtgaagga ggagacatca tccttaactt caatattatt atcctgtgta gattcatact 70200 
           ttgtgtattt tttacttaag agaaaaaata gtaataatat tcgctaggag aaacactttg 70260 
           aagaaagaaa taagtccagg agccctgtaa tgtacttttc ctctatttat ttcccacata 70320 
           aaattaaagc tgttttagtt ctcatcgcat ttatcatctt gaactcattt gccacattat 70380 
           tttatttaaa tattccttaa cctacagaga gtggacttaa ctgctaaaaa gtacttaata 70440 
           catgttccca aggaactgct tcaattacca ctgcacaaag gtttgtttgt ttttaataat 70500 
           acagtattat tactagaagt atcatcaagt catggaatgg tcaaaatatt cttacttcta 70560 
           ttgctagggt gttagaaagg actctggact acttgatgtc tagatgcaga taaaaaaagc 70620 
           agctgttcac ttcacataaa gtagccgcta ctgcttaaag gtaagggtaa atcttgttca 70680 
           ctgtggatga aggttactaa agagaaggac taacatataa aataggttca aatatatacg 70740 
           gagatataga cttaaaaaat taagacttct ccttcaatta atattccaag aaaagaaact 70800 
           ccatattgcc atctaaacac agaagctttt ctgtaatggt attccagtga aagtcattta 70860 
           aattcgaata gaaaaattta acttgagatc tgcccttatg aaaagtggtg agaattcaaa 70920 
           tagttctcga accctatttg tcatatcact tcctgaaagg atactcaatc tcttaatttt 70980 
           tttctattat tttgtacttt atggaaaaat atttaggaag attatagaaa gaaaattttt 71040 
           aggaagtagc gtctctagtt ttcctaaaat ttatgtcaaa cccggcatta tttattttac 71100 
           atataaaaag atcataactt ttactctttg ttaaaactat attaaaacaa aagagaagca 71160 
           accactaaa taataattga ttaatttcat ttggaggtct tctatgttta gtatgtttat 71220 
           ggacttttta aacactgagg attcactaat tttttttttttttttttttgagacaggatc 71280 
           ttactttttt gcccaggctg gagtgcagtg atacaatcac agctcactgc aacctcaacc 71340 
           atccaggctc aagtgatcct ctcacctcag ctaccagact agctgagact acgggggtgt 71400 
           gccaccatgc caggctaatt ttcgtatata tttttttttt ggtctaactg tgttgcccag 71460 
           gctggtcatg aactcctagg ctcaagtgat ctgtccacct tagcctccca aagtgtggga 71520 
           ttacaggcat gagccaccat gccaggcgag aatttgcttt taaatgagaaagacacaata 71580 
           cctgccttcg gaaagttccc tgtcaaattt tagaaataaa taattaaaca aagtttatag 71640 
           gcataataag tcataatatt cttgaaaaga tatgcagagg gttccaaagg agcaccaacc 71700 
           aaccagagggg gaaaatatgg gggcaacaga gaggcaagag gtgatatgag agagaaagcc 71760 
           tgagctagaa cacagagcca ggtcatgaat ctgaaggcag gaacaactct gtcagctgtg 71820 
           agacatgaat ttggaaggct gctgggagag aaaagcagag attagtcgtg caattatcta 71880 
           cttaagatat tttgggctgg aagcagtggc tcacacctgt aattccagca ctttgggagg 71940 
           ctgacgcggg tggatcacct gaggtcagga gttcgagatc agcctggcca acatggcgaa 72000 
           accccatctc tactgaaaat acaaaaatta accaggcgtg gtggcagatg cctgtaatcc 72060 
           cagctactca ggaggctgaa ctaggagaat cgcttgaacc tgggtggcag aggctgctgt 72120 
           gagctgagat tgcaccacgg cactccagcc tgggcaacag agcgagactc catctcaaaa 72180 
           aaaaaaatat atatatatat attttgaagt ctagagatga attccagaaa taaggtatac 72240 
           agaaagtgaa actgtaggac tttgtgattg actagaactg agggacaagg gagagggaaa 72300 
           gggaagagtt gaagatgatg gaaacaatag attacaggaa gaggatcaaa tttaggggga 72360 
           agaagatcag atcataatca atacaactta attccacatg ttctgaaagt taaatatctc 72420 
           ctctagccaa aagacccttc ctattttact tctctggacc tcttaatgtt tctttgatgt 72480 
           ttatcccct gcacaaataa tttaacccct ttacagatcc aaaattttat agtaggcaaa 72540 
           tattgtaacc cccttgaaaa tgtatgttat gaatagcctt tgtaggtgat atttttgcag 72600 
           tttggtaact taggacaagg tccattttcc tgtcccttgt taaatgtcac aagacttcat 72660 
           cttctctacc tatatatcac aaagtacctt ctgctctgct gatcacaagg taattaagtt 72720 
           ttggagtgga ggagtgtctt aggtttatgt tcatgcatta aatataaaga aatctatgat 72780 
           ttttaaaaaa ttaactatat tgaggtataa ttcacttaca atcatatgca ctcattttaa 72840 
           atgtacattt cttgagtttt gatgcattaa taaacccatg taacgaccac cacaattgag 72900 
           aaatcatata tcttcattat tttccccaat tttcctttgt gcctttttct agttaattcc 72960 
           ttctccttct cctccacctc caccccagcc ccatgggggt agccatgaag gtacacctct 73020 
           tggatctttt ctctccaatt agctgccagg agtgctattg gcctcctgct gcagcagcaa 73080 
           tgggatccac cacagcacag gaacccagac tggcctccag ccaatgactg ggagcagcaa 73140 
           ggaaactaca gcccagacat gtctgcctaa tgcatgactc ctcaacaagt aacctttgtt 73200 
           ggaagccaag actttcttgt aactgcactg taatctgtgg ctattcctac ccaattctcc 73260 
           ttccttctgc ctccctttga agtgatatca caactacatt gtggtttttc cttgcctggt 73320 
           ttttctcctg ttctctttct acctttcata gctattgcct gcaataaatc tcttgtggat 73380 
           ggttgtaatt ctaacaccat cttggaatca gcttcctgaa tgactgaact gatgcctcta 73440 
           cctccagcaa gcatggatct tgttgttacc atggatgaca tttgtctttt ctggaattat 73500 
           agtatgtact gatttgtgcc tggcatcaca cagcatgata gttttgagat tcatccatgt 73560 
           tgttgaggtt atcagtagtc cattccattt ttgttgctaa gtagtattct gctgtatgaa 73620 
           tacagcacaa ttgttgattg attattgtgt tgttaccagt tagagctatt aagagtaatg 73680 
           ctatcgtgaa taattctgta caagtcattg tatgaacata tgcttccatt aatcttaagt 73740 
           aaatacctag gggtagaact tacagatgaa gaaacagaag tacagcatgt aagtgacttt 73800 
           gcacaagtag gcagcacagg ttttctgact ttaaatctat gctcttaact cctatgccgt 73860 
           attgttcttc atgggaagaa aagctatttt tcttgaccca tttaaacttt ccataatgtt 73920 
           taatcaaaat attcaatatt taagttaaaa acagcaaaat ctgggataca aggtgtacca 73980 
           acctcaagta aacatgccag gtgtttggaa aagtagaaga ataatgaacc ttactacatg 74040 
           caaactgtgc aatagttaca tgtagaatgc atctcaaaaa aaaaaaggtt cctggaaacc 74100 
           acagtgctat gaaaagataa tcatagaaaa caaggataaa tttgaatacc acatactcat 74160 
           tttaagaaaa attttcactg agagaaaaaa tttaaagcaa gttgatggca tataaacatc 74220 
           cttgaaattc ttcaagtgaa tacaaattag ttgagttaag cattcagata atttgggtcc 74280 
           ttctcaggtg gcctagcaag ttagtcaaaa gataagacct gtaatcaagc tgccctctct 74340 
           cattaccgtc gttaaactgc ataggtagac ataataatcg acttgaataa tgtaccatca 74400 
           aacaacatta aatagtctat cagatcacac tgcttatagt acacattaac tactcatatg 74460 
           ctttactatc taaagcaggg ttgtccagtc ttttggcttc cctgggccat atttgaagaa 74520 
           gaattaattg tcttgagcca tgcataaaat acactaacac tcatgatagc tgatgagaaa 74580 
           aaaacaaaaa caaaacaaac aaaaaattca taatgtttta aggaagttca cacatttgtg 74640 
           ttggatctca ttcaaaacca tcctgggccg cttgtggccc atgggccacg ggttagacaa 74700 
           acttgatcta aagcaatacc atccattata attattctgt gagccaatta tgtaatttta 74760 
           aattttctag ccaccacatt taacaaatta aaaagaaccg ggtgaatttt atattttatt 74820 
           tgatacaact tattcaaaat gttatagttt ctacatgtaa tctataaaaa aattactgag 74880 
           aaattttatg ggtttttttc ataatatgtc ttgaaatctg ttgtgtattt tacccctata 74940 
           tctcaactca ggctagctac ttttgaaatg cttgatagca acatgtgtct agtcactatg 75000 
           gtattgtaca gagtaggtgtagagatcaac aggaaacatt tattgagtac ctatataaga 75060 
           aattatacta gataccaggg aaaccaaaaa gaaaaaaagt catctgtaag aagtttagca 75120 
           ggagcaacac agtgaacaga ttccagcaga gattatggca gagattactg tgatcttggg 75180 
           caaaagtgtg tatcttagga atttaagatt taagaaagaa ttttaggcat gaactatatg 75240 
           acaaacatac ataaaggcag gagaagcctg ctatgctctg gtgacaatgg atcaaccagt 75300 
           attagagaat tcacatgata gatactgaat ttcctggatg ctcagtggtt agctaagtct 75360 
           taagtttatg aatgaacaaa tgacacaaga tacaacatta gaacgaggat ggagaaaaaa 75420 
           tataaaatct ttaaaatatc agtcaaacga caaattccag cttcttatga atgaagagcc 75480 
           agttaaatac gtttgaatga aaaatgacgt gtgaagtgat atatgtggca gttaaagtta 75540 
           accaggagag aaagctaaac taccgctgca caggctcagc atctattgca ctaatctagg 75600 
           catgagttgt gtcctatcca aaccttcata atggaagaga tggggggagag aatgaaagag 75660 
           agattggaaaaaacaaggat cctaaaatca tcttatggct aaatttgaga gggagggaac 75720 
           tatggaggca tcagtgattt atatggttta tatgtaggt catgggaagt cataagaaaa 75780 
           attctggtgc caatggtgat aactgatatg aagggactcc ttgcttgaag gaaaaattaa 75840 
           gttaaactga gacctgttga aatcaaagta gtagtgtgat atctaaataa aaatgtgtag 75900 
           cgtgcaaaga gaaatatgag agtgtgtatc aggcaagaga tctggctaga aatgtaggca 75960 
           aagggataaa tagtcataag actataaggc attgcggagg gaagaggaaa agcttggaga 76020 
           atgagtcaga aatccacaca atagattaaa gatttaagtt gtgagaaagt ttttatggag 76080 
           agtgttctgg ggaataaatt agagattaat aaaagaataa aaaatcaacc aggtagaaag 76140 
           ggcatgcatc ctggtgtgtg caaacatgta tagctgcatg aatgtcaagt ttactatctt 76200 
           acgtggctat atcactatgc aaactatagc ctttcatagt acgtaagtga aagcattaga 76260 
           ggattatctg tgtagtccta aaatcctttg tgaatacatc aattgtcct attacattct 76320 
           tgcccatgtt ttacataacc agactgactg taatatgagt attgtgtgtg ccctttgtta 76380 
           ataaatcctt gtataaaccc cacaaggatt tctctaaaga caaacctggc ttgctaaata 76440 
           ttactcactc caggctaaat tttaataaat tccataaaac actatcagat atattcctga 76500 
           gacttttgta ttttaagtgc tgtcttttcc tatttggtat ttgcattggt tacttttgtg 76560 
           gggtgtgctg gtttcttcct tcttccccctt cagacactcc accccactcc tgcactgtgc 76620 
           ctggagaaga tgaattgtac tgactacacc acggtttttc aaccttggca gtaatgacat 76680 
           tttttaactg gatactttgttgtggaagga tgtcctgtgc attgtagatg tttaaaaaaa 76740 
           tccctcagtg aatcatagta gcactccact cctctccctt cctcccctga gctgtgataa 76800 
           ccactaatgt tccctgggag cacaattggc cctggattag aaccactgct acatcaatgc 76860 
           actccttttg tctacgctgt gagtttggcc agtggaaaca ccacaaagag gaaacaggga 76920 
           gggaggaaag taaggtcagg tgatccattt tccagatatt gactattctc gccctgctag 76980 
           gccagtgcag gcaggtggta tcagtccaaa gatcacacag ctcaagtcag gcagccgtct 77040 
           tcacatagga cttgcttggt catctctcct tcctttctcc ctctttttct gataaatggt 77100 
           aatctccctg ttcatttagt tcattttggc ctagtggtta taacggtgct cgctgttgcc 77160 
           atcctaaagt attgcactat tccgtgtgtt tttcctaacc cggtctaaac cttcgtaatt 77220 
           agtcccttta taaagtctcc tccaactacc aaatttgtgt gcactgtttg ttttcagcag 77280 
           gagttataat tgatatgatg taagtacata tcaaagtatt tacagaaaag caaaattcca 77340 
           aatattgaga tgttttctct gtattggccc caatcattgg aatgttttgt gcatacaact 77400 
           ttataataat cactgacacc tatattattt tcatactttg atttgctcaa tgaatgctag 77460 
           ttataaaaaa caagatcatt taaaatactt ccttgccttt attattctca ggtgaaatgg 77520 
           agatatgaat ttataataaa gagtgacaag ttagtggaat tgtaaaataa catttatactc 77580 
           aaaaaagaag aatagagatt gtaaagaaat gagattgagt ccgtaagtaa tgtataactg 77640 
           tctcagtatt tcattgtcat accttataag taagcaggga agtacaaata gatgtgtact 77700 
           tattaattta gtctttcagt cactcattga gtcaatcaat tcttgaggcc aattgttttt 77760 
           gaaggcactg attgtgctag atactgtgga tgttacaaag gtgaataaaa tgtcttaatc 77820 
           tgaggaagaa tttacaatct acacaggcat gaaaaaacaa ggaagagtgt aggtgaaagg 77880 
           gaaatttgaa tgtgaaatca ccaaggtcac aaagcatgtc tcctcagtgc tagcgaagga 77940 
           ctatataata ggctcacaaa aatatttgtt taaaatgtaa ttaaatgaaa tttgaagaaa 78000 
           gcagaaaatg tctcacaatg ctatgtggaa gttattagaa taacaccccc ttcccagttc 78060 
           ctaattgcat tcctggcata tcttatgtac attaatctat aattaaatga aacattaact 78120 
           gctttattaa tggctacttt agaaggagtg cattcattaa ggattatttt gaaatacaaa 78180 
           taatttcccc ataaatctta cattcacata tttggattct gagttttacc caagtggcac 78240 
           acaaccataa tttgtaggac aggtgaaata aagttcctac tattctggta ctgtatctag 78300 
           actgagcttt acatattttt aatagctttttttttttttttttgagacag agccttgctc 78360 
           tgtcacccag gctggagtgc agtggcgtaa tctcacccta ctgcaacctc caccttctga 78420 
           gttcaggcga ttctcatgcc tcagtctccc gagtagttgt gattacaagc atgagcaacc 78480 
           gcatctgtct ttcttttctt tctttctttc tttctttctt tttctttctt tctttctctc 78540 
           tttctgtttc tttctttcct tctttctttc tctctttctc tttctttctt ttcttctttc 78600 
           tttctttcct ttctttcttt tatttcttct gttctttctt tcttttcttt ctttcttttt 78660 
           ttttttttgt atttttagta gagacaggat ttcaccatgt tggccaggct ggtctcgaac 78720 
           tcctggcctc aagtgatctg agggtcttga cttcccaaag tgctgagatt actggtataa 78780 
           gccatcacac ctgaccaata gcttgtattt ttgaaagaag ttttaggttt gtggaataat 78840 
           tgtactgaga ttacagtgca ttcccatata ctccattacc cttcccccaa ttcccctatt 78900 
           attataattt tgcattagtg tggtacatta ttaaaactta tgaaataaca ttgatacctt 78960 
           attacaacta aagtccatag tttatattag aattcactct gtattgtaaa attctgagtt 79020 
           ttaacaaagg tataaggtca tgtatccacc atgacagtat catagagaat agtttcactg 79080 
           tcctaaacat gccatgtgct tcacccattc atccctctgc actttctcag agccccaggc 79140 
           aatcactgat ctttttactg tctccagaat tttgtctctt tcagaatgtc atatattgga 79200 
           atcatataga atgcaacctt tcaaactggc ttacgtacct aagttttctc catgtgtttt 79260 
           tgtggcttga tagctcattt ctttttatca ctgaataata ttccattgag tacatgtgcc 79320 
           agtctttttg ttcattcacc tattgaggaa catcttggtt gcttccaagt tttggcaatt 79380 
           atgaataaag ctgctataaa cgtgcatgtg caggttttgg tgtggacaca gtttacattt 79440 
           cctttgggtg aatatcatgt agcatgattt tggatcatat ggtgatatgg ttaggctttg 79500 
           tgtccccacc caaatctcat cttgaattat aatccccata atccccacat gtcaagggag 79560 
           agaccaggtg gaggtaacta gatcatgaga gctgtttccc ccatgctgtt ctcatgatag 79620 
           cgagtgagtt ctcacgagag ctaatggttt tatgtgtttg gtagttcctc ctgcattcat 79680 
           tctccttcct gtcaccttgt gaagtaggtg ccttgcttcc ccttctcctt ccaccatgat 79740 
           tataagcttt ctgaggcctc ctcagccatg ctgagctgtg agtcaattaa ataaacctct 79800 
           ttcctttata aatttccccag tctcgggaac ttctttttag cactgtgaaa atggacaaat 79860 
           atatatgtta agtatagttt agcttcgtaa gaaattgtca acctatcttc caaagttact 79920 
           gtaccatttt gtattgccag cattagtgaa tgaatgaaag ttcttgttgc tccacatctc 79980 
           accagcatgc tgtgctcttg gtgttttgga ttttagtcat tttaataagt gttttgtgag 80040 
           ctttactgtt tgatagctga gttacaaact ggcaagtatc caagcaaaga acagagaact 80100 
           ggaggtttgc ttttctaccg aaggaaatat gttgagaata caggaaagtt tcacgctaaa 80160 
           tgtaaataat tttttacagt taaactaata atgagtgatt gaaaaaagtt gacttgtgac 80220 
           atacaaatga tacaaacctt tcattgtcct ctctttcatg ggtattaata tttcatttga 80280 
           taaagatta agtactaatg actatcagta tctgttgatt gctagcaatt ttgagtagaa 80340 
           cactttttct gatatgtatg aatatataga caagaatcat atgatacacc tggattgtgt 80400 
           aatagccttt atgatgcagt aaggcaacca ctgaacttgg aatcagtgaa ttacaatttg 80460 
           tttcttctgg gtccctcact agccctgtga ctttggtcta tttgacttct gtgagcctca 80520 
           aaagtgcatt tgtaaaatgg aaattaaatt tttttctgcc catcttactg tgaagctgtt 80580 
           gtaataataa tattgacaat agcaataatt atactaataa aaagcaattt actgtgtatt 80640 
           tgaaattatg caaacaattt gaaaatcata gcactatata aaatgtaacg tcacattagt 80700 
           gttggagttt acaatttggc agggaagctg tacaactaac cacggcacaa tttgataagc 80760 
           aataaacttc ctttagagta tacggagaaa tggggaggat tataaatatt aagccctttt 80820 
           gtgccaggct ctgggaccac aattatccca tgtgatctcc atcacacctt gcagatgtaa 80880 
           attttcttat tcttatttta tacagatgat gcaactgaag aacgaagcaa gttgtccatg 80940 
           gtcacacagc taataatgat agtattttcc tattcctcat agaaaactgg agacggccac 81000 
           attatatatc cttaactaca gggaccattt ctagaaatca aatttctaga attcaagcca 81060 
           caccacatac aatatattac cccatagctt attgataatg ctaaaatatg ggatatcttt 81120 
           gcatagagat ccttaaattg tgctagaata tgagatcttt ttgcatagag atcctctcgc 81180 
           atagagaatt cctgctactc aagaatcaat gttagacatt cactctgtgc tcacagtgtt 81240 
           cttttctctt ctgtcaaaaa aaaaaaaaca aacaaaaaac aaccacctta ttttacttgt 81300 
           gaccttcagt accaagtaag actggataga atatcaagat aaatttgcga cagattagt 81360 
           gtcctttctg tcgcattatc atggttgccc agaagttaag aggtttggaa tgattccagt 81420 
           ctgataagga gaacaagaca ttgaagtaag tgtctggagt ctaaaataga tctgggatag 81480 
           ctattacttt agcttttctg agattaata tgggaatgag gtgtaaaaga agagttgaaa 81540 
           taactattac acagagatgc ttgttccttc ttcctaaggc ctaagaacat ttctcactca 81600 
           ttcttctatc ctagaattca taatggtata tggcactgca cagaaattca ttaaatgtta 81660 
           gtgaaatatt acatgtgaaa gaaggtagta atgtaaatag aacctaatat aattttttat 81720 
           gggctcattt atgttctgca ttttcttata aaattacttt ttagattgtt ttgctgctcg 81780 
           aatcattact ggttgctatc tagggatcac cttcaaaccc ctttcaaaat acaatgttca 81840 
           aaaaaaataa aaacaagggc ctggcacaat ggctcacacc tgtatcccag cactgttggg 81900 
           aggccgaggc aggagaattg cttgagccca ggagttcgag gccagcctgg gcaacataga 81960 
           gagacgctat ctctataata aataaataaa taaatatttt tggaaaaaca aatgctgtta 82020 
           aaatgcattt ctagcttagg tcacataaag gatctgaaat gggcatgtaa acaatggcaa 82080 
           gtttttat atatcaatta acaggtcttg aaaaaagtat tgactctact ggcttgtgtg 82140 
           aaatttccct gaatgaaatc agacaatggt gttctcagaa acaatgcatc ttagaagagt 82200 
           taatatcagc caaagacatt atatcatact aacttctctc ccaataaaat gcctagaaaa 82260 
           caatgtatct ctaacaagaa aaagttcaat gctgtgttaa ctggcaattc catttaaaat 82320 
           attttcaaac attcccta aggtaacaaa tataattatt aaaagcctaa taaatctttt 82380 
           aataatccag aaagaaacat ttagaagaca ttaagaaaga catattcaga attcagacag 82440 
           aagctcataa aagctaacat aaaaagcagg ttaaaaatca atttctacaa gaaaaatata 82500 
           gacatataat caaacaaaag ggggaaatac ataacaaaca ctagacgaat gcaaattttc 82560 
           aaagctatat tttaccaaat tttaaaagtt aactttaaaa gaagaattaa ccttggtggc 82620 
           agcaaaatcc atgtctgtgtgtctggctga tttgggttca attaaaatct tgggtagaga 82680 
           acacttaagt gaaaatatag ggcaaaaata attccataca aaatataatg aataaataga 82740 
           gcaaaatttc gcatataacc aaattccaac attttaagga aggtattaat ttcaagctaa 82800 
           tatccaaatt tgtctggtaa gaaaaaggtg agcatgatcc ctatgatagt ggttgccatt 82860 
           acttctactt ttgtgaggca gaataggtgg gacagctcta gggctcttct gattttattc 82920 
           tatcaattat aagaggtctg agaacaggaa atgaaaaaag ctatgaccct caagccatct 82980 
           agctcaaacg atttcactgg catctaggat ctgatatatt ttggattggg gaagagtaaa 83040 
           cacaggcaaa atttgcattg gatgtgaagc taatggccct tccacataat tttgctgtag 83100 
           gatatcaatt gattccctgt ttcagaggaa ggattgttaa gctaaaatgg tttcaaccag 83160 
           atcaaacatt aaagtaagca ggtttttca gtagatttga ctagattctt catttactat 83220 
           aaagatctgc cacacccgaa ataccacctg aaattagttt tctagttaaa tcagtataga 83280 
           ctatggataa aagaagttac gaagacaacc ctcttaatct tgatcaatat tcagagatga 83340 
           ctactcccca tcacaaaagc taattcgttt ttcacatttt tctctgctcc taatgaaatc 83400 
           ttttttgctg aagtttctga agaaataaat aaagaagcct ggtgcctctc agagttccac 83460 
           acagctgatg agtctaggca gtgacaaatg acactatatt cctcagcgtg caacctttct 83520 
           ctccctctca tcttcttgca atggaacact gctacattcc ttgcagagga aacgtactgt 83580 
           acatttcata gctgtcacct tggcataaaa ggcagaggga gggggaaatt cttcttttgg 83640 
           tctgcctaaa cattttactttattttttat atatcaataa ccatgagaaa ctattgagta 83700 
           agtttagata taaaacagag aactttgttt tggaaggcat tacttttcaa aggaaatgca 83760 
           tcgtggagag tgaggagtga agggtcaatg ttttcaagag cgatcggaag ctccctgcct 83820 
           tgatattcct aatcttcttt ctggcatctt atgctcacca actgcctaat agtggatgca 83880 
           tgtggttctg cccatctgtc caattgccat tctaaattat gtggtttact aagaaaatac 83940 
           ttaacattat atgaataatg tataattaat tataagtagt ttttaaatct tcaagattat 84000 
           tctcatgagt gaaatggttg ctttgttctt aaggagaaaa ttaatttatt tcccacgtat 84060 
           ccatgtacaa taagtagtgc tgttataaac atataagaaa atgagctatc atgataagta 84120 
           tacagcatag agttaagttt attagaatac cctcatattc tataatatac aaaattacta 84180 
           acgtgcagtg aaatcatata gaattctgaa gtagtgaatt gtttccttac tgtttaacac 84240 
           attcttgcag tttgtctttt taaaattaaa atcaggaatt ctgggcagtt agttgttttt 84300 
           gaagacaatg tcatttatct ttgctttaag aaggaaacag tctacattta acaaacaatt 84360 
           cattttctac atattaattg agcagtgaaa atatggttgg caggtctgaa gaacagggaa 84420 
           aaagacagtg tagttagagt gtagttggag ggtggcatac aaggagaaaa gggataggaa 84480 
           gtaagaagtt actgaggtcc agataatgta gggcctttaa aacacagtaa agatttgcat 84540 
           ttcattctat gtatgataag aggtcactgg atggttggga gcagagggggg atgtgatctg 84600 
           gtttctttct taaaagaatt attccgactg ctcaagaatg gactaggttg ggtgtctaag 84660 
           tggaagcagg cagatcagtt cagaggttag ggaaggagtc caggtgagaa atgatgaagg 84720 
           cctagcctag ggtggtaaca gtagagaagg gagacatggt aagactgggg atacattttg 84780 
           aattacagtg taggtaaaat tattagctta agggttagat ataaaaggta tgaaaggaaa 84840 
           aggatcaagg atatgtatgg tatatctgca aatgctagga gaccaaagtg aaatttcaca 84900 
           tagtgaaatt actgtgtttc agcagttagg gataactttt tggagttctg gaggcttggg 84960 
           ctggactttt ttgcatggat aaaattcaga caggagacat aaaagccttc ttagtggtaa 85020 
           gacagttatt agataattgg gaagtatttt gaagatactt gtctacctag aatgaagaat 85080 
           tttgttgagt atttgagagc tatatggctg aaaagaaaga ggccagataa aacaaggccc 85140 
           tgagtaacaa gagtaggcct tgggccttga ttctatagag agtgcaaaac cactggctaa 85200 
           ttttttgtaa ctaatctggc tagaaatttc cagatttcca gcacactata ttaaaggaag 85260 
           tactgccaaa aaacatttca tggattccaa aaatagagat caatgtagat gaatttataa 85320 
           gatgaatgaa ctctgggaag accaagcaga tttctgaaac aacactacca tatatttcat 85380 
           tatatacaca cacagctaca cacacacaca cacacacaca cacacacaca caccataccc 85440 
           tgaacatacc ctacacccta cataatactt atatatacac gttagtgctc tgcagttaat 85500 
           ttttataaag gcaccaatta gtttctaata agaaaaagaa atgtgtaaag aagagaagaa 85560 
           atttcattct ctccatgaag aataaaaaac acaaatattt gttagctgta acaaatatac 85620 
           atttttttct caaatcattt catgatattt atcacatgaa aaatgggtac tttggggaga 85680 
           ttttctccta aagccttcat tttttcatat atagtgagat ctaaacaacc aatttctatt 85740 
           tacagttgaa ttctacttcc aaaaacatac aactatgact caatccttgt tacctttcaa 85800 
           taaactgtta agcccaaaga tataacttat tttaaaatgt gaacctagac atttgggatg 85860 
           atcaggcatg ctagttacta ttaagaatag cagtatgtac taataaaatg gtattcagag 85920 
           attataaggg aagcactaat gaataaaaat gacccaaact atatataaag tctttgttca 85980 
           tacacaaaat aaacacatgc actatggatg gggttctcta acgacagtag aagtaaacgg 86040 
           gcagctaaag agtgtatcaa aaactgcact tttacagttt cctatatatc gtcagacagg 86100 
           ttaacaaaag tatcgaaaag ttggcatact gtggataaag tacattaaaa tgagaaaggc 86160 
           aaagttttaa ggatatatga aaatgaaagg atggcaacta gtatggtcga aattcatgtg 86220 
           ataaatcgta ataaccaacg tgatagtatt aagtggtggg gccttgcaga ggtaataaag 86280 
           tcacgggggc agagccctga caagtggaat tggtaacatt atgaaaggcc ttgagggagt 86340 
           gagttggccc tttctatctc tctaccatgt gagaacacag catttggccc tctggaggat 86400 
           acagtgacaa gacaccatct tgggagtaga gaaccggccc tcgccagata ctgaacctga 86460 
           agacaaatgc cttgatcttg gagttcccag cctccagagc tatgagaaat aaatttctgt 86520 
           tgtttgtaaa ttacccagtc tcatgtattt tgttataaca gcacaaacag attaagacaa 86580 
           cagctttctc agagcccaaa acatttataa tagtaagaat ttgcaaaatc aaacaatgag 86640 
           taaggcctca aatgatcagc tgtacttgct aaaaatgaaa gaacaactaa atcactcaat 86700 
           tcacttgggc aagacaatcc attattcgtc taaaattttt gttaataatt ttctgatta 86760 
           ctatctaata gtactggata ccatacaacc aattactcct acaaattttt ttgttaatag 86820 
           ttctctgttt tgctttttaa taatactgga taccaatact ggatatccaa aatggtttga 86880 
           tagttgggaa caaaggggat aaaggaaaga aatgtactat aaccagagat ttttgaaaaa 86940 
           taatgagact gtatgtacta tgatacttca ctcagaaaac ctcacttcaa acttaatggg 87000 
           aagagaaaaa gattggggaa gaagtcttca agcacagtcc ataatattga tagtagact 87060 
           cctacacata ttaatggttg acagctagat gtcaatgcct agagcacaac aaataggtct 87120 
           tatatatcac tatatttttt atgatgcttg gcattgtatt ttttttgttt gtttttgaga 87180 
           cggagtcttg ctctgtcacc caggctggag tgtattggca tgatctcagc tcactgcaaa 87240 
           ctccatctcc tgggttcgag cgattctcct ggttcagcct cctaagtagc tgggattaga 87300 
           gtcgtctgcc accatgcctg gctaattttt gtatttttag tagagacagg gtttttccac 87360 
           gttggccagg ctggtctcaa acacctgact tcaggtgatc cacccgcctt ggcctcccaa 87420 
           agtcctggaa ttacaggcgt gagccaccgc accaggctgg tgtagtattt tatacacagc 87480 
           atgcatcaac aaaatggatc agatggatgg gtggacaaat ggataattga aagaataaat 87540 
           agcagaaatg ataactctaa cttttaagag tctatcaagc taaaatgact tttgaatcag 87600 
           tcgaatgaat gtacgtggga actgggaact taagaaagag aaggagcata aattgcaatt 87660 
           gtggctaaag cagcagaatg cttatttaca taagttttaa ccagtgcgga atattgtaat 87720 
           taccattat gttgtttttt tatgaatcca gtacatgctt attaaaggga attggagaaa 87780 
           ataaaaataa gaaaggaacg caataatcca gactgtaatc taggacccag taatagttac 87840 
           ttagttgcaa aatttcctca agggcaatat gagagagacc attttgtgct tgttgccatg 87900 
           ctgggggtgc ctactggcgt taaagaggta aggcccaggg cttgtaaaca tcctacaatg 87960 
           aatgagagtt ctccacagcg aagaattacc cagcccaaaa tgcaaaatgg gcttcactga 88020 
           gaaaaactga gtaccttgtg catttatcc acgtctttat atgtacataa gccacataca 88080 
           ggtttttaaa aaataaaaat attatgctgc acaaactgct ttgtaatttg ttcttttcac 88140 
           atactgcaac aatagcatcc ttccacacca ttaataatta ttctacaaca ttttaatggc 88200 
           tgttcagcaa accactgcat ggatcaacca taatgcattt aatgaggtcc ctatgatcaa 88260 
           acttctagca ctattttttt caattttgtt ttataatcaa ttctgtgata aacatcttca 88320 
           tattaaact tatgatcata tttaaattct tagacatgcg actggtcaga gcatgcataa 88380 
           tttcaatgct tttgatagac ttccaacatg tcctcaaaaa tgacttttat tagtttattc 88440 
           tctaaccata ttgttctgat tgatggacat ctctaacata aagttgctga aaatatgaaa 88500 
           catcagctga ggcactgtga ccctgggaac tggctggtcc cttcctagcc cacatcttag 88560 
           tagaagatgc aagggttat gtggaatacg tccgcgggtt aaaaaccatg tatcaattct 88620 
           aaattccaag tgccagaccc tttcattacc tttcattagc gaagtataaa aagaaagagg 88680 
           gagaagggat tttcaaggaa agtaataaga agggaagtat tagtggaaca ttagagtttg 88740 
           tctctggtcc ttcctctgag tggggactca tgaggcttgg tgttgtctga aagcaggaag 88800 
           gacttgggtc ttactccctg gtaggatgca gcctgaggag caaggccggc agtcacagtg 88860 
           tgagcaaaca ttcatacaga cgtgggggct gacatatcaa gttggagaat gtatgctcac 88920 
           ttcctgtcac ccccataacac cctgattccc aagagttgag gcagttgtgg taggggttct 88980 
           taggtttccc atgggctcag attaggcctc ggacggaagt gaaggcagtg gctggctggg 89040 
           tgaaatatgg cggacagagt cggtgagtaa caggagagca tgttatccct tttagacccc 89100 
           tgaagtatta gagaggatca gccaggcacg tttagaccat atgatgtatc atattgtaga 89160 
           ttcaccccaa ggcatttgtg gctgtgcagt aaaagtgcag gatgaaacca gactctctga 89220 
           agggtaggga tattcccgtc cctatccctc atcttttccc cctttgcaga taaaccatcc 89280 
           cactttcaaa tgaacttggg aggagggggc tttgaactgt gcttggggtt gtttctcctc 89340 
           tggaaatgct tccattctaa aaagttctgg catagggaat tggcctaagg aaaaactctg 89400 
           ccctccttcc ccttaatgga ctgtcctgcc tttgagtgtg agtaaaaggg gctgagatca 89460 
           ttcatcagcc aattttacag ctgcaatcta cttagacctg cccccatcta ggtcaccaag 89520 
           gatctttgtc agcatttggt acaaagccta tgtgaatgaa gatggtcatt tctttggtgt 89580 
           tgtcccaaga aatgtaacag aaaatgacta taaaagaatg gattctgata tgggatgctg 89640 
           agtcctgata atctctctaa atgtctttca tctaggacct gcaatcagcc atttattaaga 89700 
           aaaagagaaa aggattgcag gggacagttc caattaacct gtggcatccc aaatctgtgt 89760 
           tttactgaac accttagaact attctccatg ggtttggcgt caaagaggca ttaggaaaga 89820 
           tggtaactat tcctcttaca tacaatatta aggcctttga gatttgcttc agcttaacag 89880 
           agatactttt aaactttgtt aatttaaatg tttcccaaaa ttatttgagc agagaatcca 89940 
           ttctaattat accatgtgca taatactcaa tggaatcaca tgactttggg gaaatcagag 90000 
           gaaaactaat agtgattaca ttttatttag ctaaataaaa cggcatgttc agtgatgctt 90060 
           ttccctcttt gtgttataca atttacttac ttaatatcat caaactacaa aggaatatgg 90120 
           aaaagatttt ctgtgatcat gtatcgacac acttcttaga gaaaatgtaa gttcttggca 90180 
           aaatattaca actgtataat gcactacaat ttttaaaaat cttttgtctg cattatctta 90240 
           tttcattcac actccaaccc tgggcagttg gctggccagt tacagatgag tagctatggt 90300 
           ttagaaaggt tacatgagtt gccagggatc tggcaacgca taattgaata cattgtctta 90360 
           agattcaagc tattaaacac agactgaaag cattttgaac tcatttaatt caacattttt 90420 
           atttcacaga taagaaaact catgcttaga gaggggagat gacatcatcc agtagagtga 90480 
           gagagagaag accaactctc tgttccctga attcaagccc atgccctcca caccatgcca 90540 
           tgttttccct gtatatgacc aaacaaaatg gtgcagttaa accacgagcc gtcatgcaca 90600 
           ggagggccag ctggccatca tgctggatca aacagcagat atagaccatc tctagcagaa 90660 
           cacttgtgaa ttgcctttgt ttcaaactca taaatgttag tatacctttg taggaggact 90720 
           accatgaaag atgaattgcc actataagca gtcattagta tttagtggag attaactttt 90780 
           aaaggtgcct actttagata tgtcataata ttagaaatta aggatgaagt atttctatct 90840 
           atctatgctt tgtaggacaa ttatattaat cccaaagtta cctgacataa gtaggaagca 90900 
           catgcctctt ctgatatata gcaaataata tatactcaat ccactgagca aaaattggaa 90960 
           cctcaaggca aagctgtatg tacaacctca gaaaatctgt gtggcatgaa ataccgtaac 91020 
           gtacactgaa agggcaattt tcgatttttg tgaggattcc caatagccaa atagaaaaaa 91080 
           agtgtgtata catgtgaatt ggagatgact tgatattaag gattgtcaga cttatgtcac 91140 
           cccattgtaa gcatagatag ttaaaatcta tttgatttca ttaaattaaa agtgtacatt 91200 
           attcatcaca atccataatg taactgaatt cattcctatg aactgaattc caattagatt 91260 
           tatcatattg ttgttgtgaa caccagagaa aagtaggaca gtcccacatc taagcaggaa 91320 
           gataaaatat atatccgttc tttatttcca ttttttcact tacttgttca ataaataatc 91380 
           tatttattca acaagcataa tttctggctc agtattcttt gcattagtat tcactatgac 91440 
           attaataaga attaaatgct actttggaat tttcacaagt aactgcttag tgattccaga 91500 
           atcacctggt agaaggggat atttaaattg caacttaaaa atccaaatgt tgttaaaagt 91560 
           tttaataaaa tttcttataa aaattacttc atatacgagt tgacaaattg ttcattttct 91620 
           ccttgtagaa gaacaattaa attgatgaga tgtatcatct aactctcata cacgtaatta 91680 
           tatatttgca tgacaaatac aattggcatc tcatttacct catttctgta cccttgaata 91740 
           tcacgtaaac atattttgtc ctgattttta aatactttga atagtttgag aaccaaaaga 91800 
           cctcttttga caatttcctc ttgataaagc aaatagcatc atcaatgtct ccctaaaact 91860 
           taaaagctaa cagcctatgc ttgaaggggc agaaaagtca agttatttct tactttttag 91920 
           ggacaaacag gttgtttatc attgtagttg gagacaagat atatggaata atatataaac 91980 
           acatcttatc ctatttatgc ccgtcaccta aacatataag tgctattttt ccaagtttat 92040 
           tatcaaatta caaagtggaa atatggctca gatggtagta gaggtaaaaa caaacctaag 92100 
           tcatgtaaga tgagtaagtc taaagatcta atgtacaaca tgaagattat tgttaataat 92160 
           attgtagtgc atactggtaa tttttcaaga aagtagattt taggcactga tagtaaaaaa 92220 
           gcaaagataa ccatatgatg atgggtatgt taatttgctt caatgtagga atcactttta 92280 
           tatacgtgtg tatattatat atatatataa ataaagataa gtatctcaaa acatcatgct 92340 
           gtacaactta aatgtataca attaaaaata attttacaat acaactaagt ttgaagtcat 92400 
           cctacattta acagtatctc attaatgaaa ccagcaaaat tatcatgcca tctttgcaag 92460 
           tgaaggaata ctaacaatag acgttagcac atgcacagta aaaatgggtt cacagaagtg 92520 
           tggtcattgc tctcacgttg cagtccacag aattttaagc tatgttaaac atttatgaag 92580 
           gaacaaggga agtgcacaaa tatgatttaa acctatttgt tggtgtaacg tgatgcagtt 92640 
           ctatcccact catcctataa tacatttctt tgacaaacaa aactatcatc gcaatcagtt 92700 
           ctttgaatat taaaattgga tgtatagtca tgcatatgtt gtggggattgt aatgcttaca 92760 
           gactattaac cactgatcct aagatttggg tggaagtatt tgtctctata tctaagcagc 92820 
           taaaatatca tggctactat ctgtgcgtgt atgtgaggta atttcagtct actgacaaaa 92880 
           acacaattta atgtatgata tttatgaga gcatcagcct ctctcatttc taagataaat 92940 
           ctcttttttt ccatgatgga tatatacttg taacaaacca tattgttctc agagaccaca 93000 
           gctgctccct ttttcccagg gtaaatatgt cagtctcccg gcctgaactg cccatttctt 93060 
           gaaggcagga gccacccata tgttactcag ttttgtattt ctcatggtgc ccagctgagt 93120 
           gtctggcaca tattaagtac tcagttaatg atttttaatg aaaacatagc agtaagccta 93180 
           ttttccttat aattttatac ataattacag agtactttcc cacctagaac cttacaggat 93240 
           taagggtcat tagaattcac tattcatcca tcttgaaccc agtgaaattt tgtcagatac 93300 
           aaagaaaggc cataataatt gtgtttctaa gtggggacag tttatgtacc attagtgggc 93360 
           tctcatatga gtgagaaata ccaactttta cataccacat tgcaaaatgt cactgttaca 93420 
           tacctttaga aacaaatcaa tcttaaattt ttctttaata atcacagtat gctttaatct 93480 
           aagattatag tgccagtaat agtatatgcc actcgaaaca caaatacaaa tcaggcaatt 93540 
           cattgtgtct caaagctttt aatttaggtc taaatatacc taatagtcat ctggttatct 93600 
           tctgaagtca agcacaagga caagaaccaa acttttaatt atttgaggca atgtattata 93660 
           ttaacaatta ttagacactt aaggggaaag cttactataa attaaaatat ttctccagtc 93720 
           ctgacatctc ttaattactac cttgttataa aattatttta agattatgcc tgtgacctgt 93780 
           gtgtgcttct tcaaagaaat ctgaaatgtt gcctgtgacc tgtgcttgtt tgtgaaatca 93840 
           acattaaatg attcagctga tggcaacata catcatctga ttaatcattt aatcagaggg 93900 
           tccataacac tcaagtgttt aaaaataaat tttcatgaag cccaacatga cagccatagt 93960 
           aagtcaaagg aaatgagtaa aaggatactt agatattata ttcacaatgt caaacctgac 94020 
           attttaaaac ctgcttttttttattcatc tagcacacaa ctggctagct atccttttat 94080 
           gaattaagtc aggattatta cagaatatac acgtgtcaat ccatttgaaa tcaagattatta 94140 
           aaaaaagttg ttcataatat attgatgtaa tttttccaaa atggcattgc ttaggaactt 94200 
           cattctgatt ttgaacaaca ataaataaca tcgctgaacc tggatgtttt aagtatccaa 94260 
           ggcaacagac atttcaagct tatttcttgc gtgaaaacta ttaatcatca tgtagataag 94320 
           tcgtgtctca atgggatatg ataacgaagc tgactgctgt attatttgtc aggcagtggc 94380 
           ttcacagttt attcaggact tttgctctct aaaactccag aaaattacaa aaatataaaa 94440 
           acttcaggat ccaactcttt tagagcattc catgtggcat gaaagagatg ctcattagtt 94500 
           cagcaaggat ttatttgagc accagccaca agcaagacac tgttgaggag ctgggataga 94560 
           ccaagtgttc tagtggctac tccaacactgc acgcatagta gcattacaga ataacgctga 94620 
           ttcaagtcac tttctttgta caatattctt agaacaagca gatctttctt cttcaataga 94680 
           agtaggaaat ataaattttc tctatataac atcactgttg ctttgcactt aaaatttctg 94740 
           cctgtgcact tttaacctgt ttctactctg ccaatgaaag gtatgaactt caagaaatga 94800 
           attgtatgac tgataacttc ttatgtgcac atgagtaaaa atatggatca aaagatctat 94860 
           tattctaatg tactaaacac aagagttaat attgttctgt aaaacaaaat cttataattc 94920 
           aagataactc atttgtccctt taactagtct tatacttaga aattattact aagggcagct 94980 
           acattcatat gatcaaatta acaaaacagg tatctgcttt gatttactct cgattattg 95040 
           gttgttcaga attatgtcat ttaatttcca cctatttgtg aagggagagg gaactttccc 95100 
           tccctcatca actagagggt gatggaccag ataccctcaa agggcatgaa aggtgaaaac 95160 
           cggtgccatt actccctttc agtgttcctg atcttaaaag cagagccatt aatccacttc 95220 
           tacaagctag acatccagta cccctacttg tcacatccct cttcctccaa gtttctggca 95280 
           cagtgtgagc aaacattctt tcttgaatga tgaatgagtg tctcaatgca gtcattaata 95340 
           agcatttcaa gcaaaaagag tttgcttatt tctatttacc agggtcattt tgatcaaagt 95400 
           ttaaaaaatg aaataaatta tttcaaagtt cataatgaac aaattaaata ctttcattga 95460 
           aaccatccag attttttagc atcccataga tgtgaccaca attgcagaca tttattatagag 95520 
           tattctttga atttattatag aaactcagaa ctttatgct aaattagact tcaacaattt 95580 
           tctagtagag cttcctcatt ttatgagaaa gacttttagg agatctgcga aaggttatcc 95640 
           agtcaggtgg tgtatgagca gagaggaaga ctagccattt tcactctcag tccaatgttt 95700 
           atttccacaa ctatgctgca atttctaggt tctatggctt cattttcata ttagaaatca 95760 
           gtaagaaact atactaccta taagggaaat atctccaaat gattaatttt gtcacatcac 95820 
           ttagatttct gctttaaata ttaaaataaa tagaagtatt ttagatggg tggaaagcaa 95880 
           accccagtttt gtaaaagatt aagcactttc atgctccatt tgcaatttt attgtatgcc 95940 
           ttaaatgcag gtgaataaaa gacggtacat gtttccctgt tgcttaatat tctgaagcaa 96000 
           taaaatcctc tagttaaatc tagttgtcca taactgaatg tataaagacc caaaggaagg 96060 
           taagttttga ggaagtgctt ggggaagtga tatagtggct ggaaaagtac tactggtgtc 96120 
           cagtctattc caaatgactg tgcaatcttg gactacccac ttcctctgta gatttctgtt 96180 
           tcctcatctc tacaatcaga agattgatct gaacagaggg tctgtcaatg gacttcccat 96240 
           taagctcttt gatgtgcgta tgtgagtgcg catttttctg aagctaagag ggtctatagc 96300 
           ttctattagc ccgtgaaaag ggtcggagac acaaaactga ttaattgcct gtgtactaat 96360 
           ttaatctgag gtccctctta acttgtgaaa tcttacgaag ctataaatag aattaaaatt 96420 
           ttagatggaa accaggaatt aatataatta ttatccctaa taagattatt tgaaaagcat 96480 
           attttgtaca aaggggtacc accatgacca accatgcatt caaacattag ctgaagaact 96540 
           tcactagaag cccagtaagg atttgccatc attagcatcc attgcaccag acactagaca 96600 
           tgtaagtaca tgtagtaaat ctaaatatat cacagatatt tttgttctgc ctttttatta 96660 
           tcagagtttt aatgggctat caaggtaagg ctgctactta ggattacatg aagtggaaac 96720 
           aacccagaat agtttgccag caaataaaac ttctttctca caattttcaa gatattcatc 96780 
           caaaatcatt ttgattgtaa cttttggata gctgaatagc actgttctta tactaagcat 96840 
           atgattataa aagaccccaga aatgaaagtt gttgtgctta ctcacttcct tccctcctta 96900 
           atttaataaa tgtttgttaa ttgtctactg taagttggaa actctcccag acacttgtga 96960 
           aatatcaatg aacaaaataa atatatttca ctctcatggt gcctacattc tagaagggag 97020 
           aaataaaata aaaatcatac attaaagtaa gcacattatg tattatattt aaaggtgaat 97080 
           aacactttgg caaagaaagg aaaaagaaag aaaaggaaag aaggaaggaa ggaagcaaga 97140 
           aagaaaaaag agaaagaaag aaagggagga aggaagggag ggagagagggg aggaaggaag 97200 
           gaagggagaa aggaaggaag gaagggaaaa gaaagaaagg aaagagagaa agaaggaaag 97260 
           aaagaaagaa aaagaaaaag aaagaaagaa ggaaaaaaag tagggagact gggaatacca 97320 
           gaggtgagaa gaatggctcc aattttatat agattagggc aggcctcccc aagaacgtgt 97380 
           cagggcaagg gtatgcttga tttattcaag aaatagcaag gaggtcattg tggcagggaa 97440 
           aaagcaaaaa ttattttgct gttgtagtgg tgatgtttgt gaaacttcaa cgttgttgac 97500 
           acctcatact gtattagttc catatttaaa atgaaagtta taatatcttt ggtataatct 97560 
           tattcgtgtc ccatgtttgt caaaaaaatt cagtcaaaat tcttctcaga attttaaaat 97620 
           ctacctcaaa actatatctc tggttggtat gtattttaag tctctcattt cccacaaata 97680 
           tgtatttggc aatgaactgt tatgtaatat gcagatatgc catttaataa gagatgatgt 97740 
           cactataaag aaataagtaa aagaacttta ttttggaaat taggaaatta ggcacaaagg 97800 
           gatttgttac tccaaggaag agaaattcca agacttacaa ttaacatgaa agccctcatt 97860 
           ctttctgaaa tgtcactgtt cctttggcat tttaactacat tttttgtttc attaactttc 97920 
           ttccagaaat tgaaacaatc ataataatta taaaatttgc atggcattta tctgggttaa 97980 
           tgcctgaaac aagcaagacc aatataaagg tagcactttt tcacaagggg agggtcaggt 98040 
           agccgttccc cacagtaagt atcttgctcc tgcctccagg cctcacatga aaatgaaccg 98100 
           taatctcacc agcttataaa tgtaacacaa aacgtacaca gccatacctt gcccaactgg 98160 
           tcctttttga caaagccagt ggctgctgca atgctccctg ctccctccac tgtcttctgg 98220 
           gctactgctg tcacacccgt caccactgct cctccaacat ttgtcacttg ctctttggtc 98280 
           ttctcagcca ctggtacaaa taaagagcaa caacagatta aagggtggta gaataacagt 98340 
           gacttaaaat cattccactt ccctagcca tcggcttcca taacacctgta tctacacatg 98400 
           ccatagataa ctgagtggtc agaagaaaca aaagccacca agatgtccaa gtgagtgtgg 98460 
           ttcaaccaaa cattgaatct tggctaagat attttggcta aagtcatgca gttattaaaaa 98520 
           gtgcttcaag tttaacgatc aggaatgtaa agccatgagt gatttggatt tggtttatac 98580 
           tatggaaagt ttacagaaag caattcttac aggtgcagtt atatttgaac cagactcagc 98640 
           atgaatattt ctttatttca attcagtgcc aatcctttga tctcactcag caagttaatt 98700 
           tccaccacac cttctaagca acacaataca tacttctatt tattattatta tttgagatgg 98760 
           agtttcattc ttgttgttca ggctggaatg caatggcaca atctcagctc acagcaacct 98820 
           ccgcctcctg agttcaagct attctcctgc ctcagtctcc cgagtagctg ggattacagg 98880 
           tgcccacaac cacacctggc taattattat tattattatt atttgtattt ttagtagaaa 98940 
           cagggtttca tcatgttggc caggccggtc tcgaactcct aacctcaggt gatccacccg 99000 
           ccttagcctc ccaaagtgct aggattatag gcatgatcca ccgcacccag cccctactta 99060 
           ttatctacgt gttcagacgt ggtattatca catatgtacg aataacagca taagaaacgg 99120 
           ttgtgaagga acttggatct ttttatagaa cttcaggtag tgaaacaaag ggttcttaaa 99180 
           aagctaaatt tgcagtaatt ttaataggag cacaggagct agacagtatg aaaatgaaga 99240 
           ggctattgag cacccttaca atttcttttc ataaaacaaa atgagatacg gtcattcagt 99300 
           agattattatta aaataagtta aatttttga gaagacagtg taaatagttt gaattgagtt 99360 
           tacaagcaga agtttaattt catgtcaaaa actttcttgt tcagttaaat aagccagaaa 99420 
           cagaaaggca aacaaccaca tgatctcact catgtggaat ctaaagaaaa agaaaagttg 99480 
           atatcataga agcagagagg agaacagtgg aggagagtgg aggatggggga cactcatcta 99540 
           aggaaatgaa ggcacatttt cttgacatgc tttgtactcc ccagataagc ctcagtctga 99600 
           gaggagttac accatgtcag ctgtttagtg ctattcacat gactattgta taggtttcat 99660 
           ctcaccagtt gaagaagcca atatttactt atttattatt ttattattt attttgagac 99720 
           ggagtcttgc tctgtcaccc aggctggagt gcagtggcac gatgtcggct cactgcaaac 99780 
           tccgactccc gggttcaggc cattctcctg cctcagcctc cccagcagct gggactacag 99840 
           gtgcgcgcca ccacacccgg ctaatttttt tatattttta gtagagacag ggtttcaccg 99900 
           tgttagccag gatggtctcg atctcctgac ctcgtgatct gcccgcctca gcctcccaaa 99960 
           gtgctgggat aacaggcgtg agccaccgcg cctggcctga agccaatatt taaatggtgt 100020 
           ggacaaagca atttgttttc aaatagacta tgtaagctaa gggggtctgt aaggacaaga 100080 
           ggctttctcc ttagtacagg caatgtgggc aagcctgaca tagccacaca gcccaagacc 100140 
           agaaacggtc cacagtagtg ttgctcccta tttgtctttt aggctagaat tttgtacaac 100200 
           tacctaacaa ctccgtgcca cttctaagga tatggctgat gtctccttaa gagcaagagc 100260 
           tattacaat tcaaagttcg atttaaatgc cagcgaaaag ctgtactgaa aatcttatgt 100320 
           tttaaaacat ttctgaaatg ttgatccttt aaaaatagtc aattatgtgt ttcaagttgt 100380 
           catttttttc cttttcaagg acgtgaattg aaaattttgc ttgaaacgaa cattttcttg 100440 
           ttataaaatc tcaaagcgag attaaaaata ggttttgaat tttttacaga tccagccata 100500 
           aattttataa tatctagata gccttttata tatgtataaa ttttaatcta gttttaatgc 100560 
           aatacactgc acagtaaaat gtactctaca cattattata attttgttgt tttattatta 100620 
           taatcataaa taaaatggct acattacaaa atgacagagt gtacatgtag caataatcga 100680 
           cacatttaaa aacatttctg tagaactgat ttctctagta gggtctctgc tgacctttaa 100740 
           cctctatttt tccccttgag ggcctttcac actatctctc tactcactga cattccaaat 100800 
           gacgggtgac aaaacaaaag gaaaagagac acactcatat tagtacattt tgggtctaat 100860 
           aaatggtaac tgtttttcgg caattgagtt ctttgaaatc agggattctg ctttattttt 100920 
           ctttatatta tttcatagta gataataaat aatttagaat atactaaaat gaatttagtg 100980 
           tctacctcta atgtctgcat taatataaat aataggttta tatttgactt tagctacttt 101040 
           aaaaataaaa ttccaaaaag gaaatgtgat accaactttt agaaagata tagccaaatc 101100 
           taacctttga cattaaacaa aattataaaa ttaatatatg gttttgaatt gttatacaag 101160 
           taaatatgta tatttaaata tacatatgta aatatggatt taaagaaaat aaatttgaaa 101220 
           caatttacta aggaaattta aatcataata tgttgaaaat tagttttgtt catttatgatg 101280 
           taataaattt ataagaatca aaaccttcag aaaatctcca gtgttagaaa tttctttata 101340 
           ctatacttgc atgaaaaata ggtaacttta tatcatagtttatttttaaa gtacctgaaa 101400 
           aaacatatca ttcagtaagt ttaattaaac aattttcat atatttctat aatatgatgc 101460 
           attaagttga taactgaaat aatttcctga gatcaaacag ccaggattta agttggtgga 101520 
           tttttcattg atattatcta actaggataa tttattttat ttgaactttg taggtagaaa 101580 
           gttcccagcc caagtttact gaagtctgta tttctcccct gccccaccga aaaaaaaaaa 101640 
           gctaatggga tgaatttagg ggaaattgtt tctttaatat tagaagataa tattaggtac 101700 
           tatgtaataa tttcttgttt ccctgcatta agacttgtag caagaacaat taacaattag 101760 
           ttagcactta atatgtaccc ataataaaca ttttacatca ggcataatat gcaaattatt 101820 
           ctccctctct ttaaccattg aagtgtaatt atcttatttc ttctcataat tagacttaag 101880 
           cactttatat taaataaccc tattcaaaaa gttaattcat ttatctgatg tgggagagga 101940 
           atgattatga tagcagccga tttatcccaa tgtgtttctc atagccatac tagttatgac 102000 
           agcatttttg gttatttcac tactgccagg gtggtccatg ggtgcaatcg ctgtaaatat 102060 
           tgcacatgct gaaatcacca tgtccttact gcctagcaac atttcccata gttttctgtg 102120 
           gaacactagt ttcattcaac cctagtaact aatgaagaaa gttttcaata atcaaaaagt 102180 
           ttgaataacc ctgattttaa ctatgtaatg caaatttctt tactgtagga catctcagat 102240 
           tccttaatac gctaaagaga aaataaagta tacaaagtct cccaacattg tacaatgtta 102300 
           gaaacttaag attgtgagcc actgtccttc agaaaacatt ttataaaatg tctaattgta 102360 
           caaacttcag tctctctctc tctctcacac acacgcacac acacacacac acacacacac 102420 
           acacagatat gtgtttacat tttggcattc tggaaaagac taaaaaaatg cagcccatct 102480 
           ccacagtctc cattagatca tcaggtgaca gtaatagttg ggttctttaa tttttaccac 102540 
           tgactccaga acttgccaca tgcttgtctg ctttctaaac ctcatgggtt cttcctcaac 102600 
           tactaaatgg aacaccattc atctaggttg accgtcttca gatagtggag tctccacctg 102660 
           tctgttatct agttcttatt ataatcatgc ttcacaatat catatttata ggaggtccct 102720 
           agaaggcatc atagtccact tacttaacta cttctctgtt ggattgcaac agagcccatt 102780 
           aaaggtgcac aattaacttc taacagaact agtttcaaag gagtctgttttatttttaca 102840 
           ctctgatttt taaatcaaaa gtattcattt aaagaaatat ttttctccac tagttgtaaa 102900 
           aatgttgcac aagaaagttc actataaaac tataagtaac acttataaaa tacatattgt 102960 
           ttgcttttgt tttccagatg ttttgtgtac attaattcac tgaattattt tatagatgag 103020 
           gaagctaaat cacacagagg tgaagaatct tgcaaaaaac acacagctgg taaggagtaa 103080 
           gcaggaagtt gaaccaagaa gatctgactc ctgtgttttt agtcatatcc acaacactgt 103140 
           attaagattc ccatatcatt gtcctcattt ccattttaga agtcagtgat aggaacattt 103200 
           tatttgtata ggcactattg tgtttaatgc tttccgatta tataaattat atttctgatt 103260 
           atatcttttg cttcaccaca tctgccagga aacgtggagt acttacaaca gaaaacttaa 103320 
           ttacagcaag tctgtgggct tttaatttgt taaattttgg ttctcctttg atttctctat 103380 
           ttctggcact ctcatcctca tcttcctcaa catctgatga tgattatcat ccttttcatc 103440 
           atttttgata tttcttgatt gtaaacctaa ttgacttgtt caaattctcg gtaaatttag 103500 
           gccaaatgaa taatataatc agaaatgtaa taattgcaca ataatatttg tacaaatagc 103560 
           tataccataa caatacaaag ataaatacaa taaacatttt actgactgtc caagggtgtt 103620 
           tcctgaaatg cactctgaat tatcaaagga atattgtaat caacataatt taaggtcaaa 103680 
           atattttact gtaatcaaca gaaattttac tttttttaaa attatggcaa tattcacatt 103740 
           ttatttttgt cagcagtttg tcaatacatt tttggtcaga atatttaaat gcccacttac 103800 
           tataaattaa acatagctta tcaattcaaa gccctcatta ttcttggcaa gtatattttt 103860 
           tatttataat caatatttac ctatttaaaa atactttata aagaattcag tttcaataag 103920 
           actgatatgt tcttgaatg ctcagtgatt gttttacaat ttcataggaa tcttgaatac 103980 
           tgggccacac taatcactag atactttaaa tatcatcttt ggatataagc acaatggagc 104040 
           ttacctgttg ccacaccatg caccactccc tccttggttt tggagcctac aaaaacaaat 104100 
           tcaagacata agtctcaagc tagccttaaa ttgctgatta gctagttttc aatacaacta 104160 
           atttaaaaat ctcaatcttc agaagtatat atattattat atcttcaggg aaagaaaaaa 104220 
           atatatatat atatcctaaa actagaagaa ggaactccag taaccaccac aataaataga 104280 
           agaaagccca gctaacagga ggtcctctcc aattacgatt ttagcacaaa ataatgactt 104340 
           tatccccttt gttcccacat cacatgtcaa cttacagagg agaaaaaaga atgagataac 104400 
           accggggccc agtgagaaga taattttgaa ttcagaactg tagaagcttt aaaagtacag 104460 
           cactagagac agatcagtca acccatgaaa caaaagggaa gaaggatgga gagaaggctt 104520 
           taacatgtgc tgaacaccca ttatgtaaaa aaaacatttt aggctgggcg cagtggctca 104580 
           tgcctgtaat cccagcaatt tgggaggccg aggtgggcag atcacgaggt caggagatcg 104640 
           agaccatcct ggctaatatg gtgaaaccccc atctctacca aaaatacaaa aaattagcca 104700 
           ggcgtggtgg cgggtgcctg tagtcccagc tacttgggag gggctgaggc aggagaatgg 104760 
           catgaactcg ggaggcagaa cttgcagtga gccaagattg tgccactgca ctccagcctg 104820 
           ggtaacagag caagactctg tctcaaaaaa acaaacagac aaacaaacaa acaaacaaaa 104880 
           aacacatttt acatatcatc ttattatc ttcataacag ccatttaata tagttatatt 104940 
           atgcccattt taaatagctg atgaaattaa aaatccgagt taagtaattt atgtaacatt 105000 
           acacatgtaa taataggcta taagcacatt caaactaggg tctctacaca ggatcagaat 105060 
           ttcttccaaa ccttgaacat tactaaactt gaatacaaat aattattatg tgtatttatta 105120 
           aaattatgct tgtaaaaaat tgtattcata tcctctctaa tgttggattt ttcagtgtaa 105180 
           ttcacactgt ataatttatg gaatcggcat gatttttatg ttttacagaa ttatcatact 105240 
           cctttttaag tttggatcag tttacaaaat gttatcattt gcactttaat gtcatgatat 105300 
           actgacagtg tattaacat aaggtgtatt tttcagcaac acttcctctg ggacaccttc 105360 
           actctttatc acaacctctt tccccattat acggatacct tcacctcact acgttcctct 105420 
           gactgcatat ttagagtctc ctgaattgca gcagtgacaa catcctcagg gtagctactt 105480 
           cctgtataca tcaacttatg tttgattcaa attttacttc cagaatgttt cacttccttt 105540 
           gtttgctact ctttcatctt tgctggccag tttcctcttt tgattgcgca ttttcgtgaa 105600 
           acatcacatg ggctcaccac tgggagacaa tgtggccaca caagtccggg cattgctgtc 105660 
           tgtatgaact gcataacaga tgtgaagcaa ccaatctcca aaaagctttg aaagaagtgc 105720 
           tgtggttttg tcactgatta taatgggttt ctgttattta tgtaatgatt tgaaggctga 105780 
           agagttagca gcaaagtttg tactttatgc aatgactttc ggtatactgt ggtaacagaa 105840 
           atttgaattg tgttgttagt ggctggtgtt atttaactaa ccatagtacc tggaatttgt 105900 
           ttgtgctgga actatgcaga gtgagaacag ctgatattta agagaatatg tttcaatctc 105960 
           tatctctcat cctcaccacc tgcacccccat gttgtcttaa aaatgactag tagtaagaaa 106020 
           tgtctaacag ctggaatgcg atctttgttc tttgccttag cagtacctaa gaatttgacc 106080 
           tttggttaaa ttatgaaaca tattctaaat caaagacaat gagatagaag tagagagtag 106140 
           aattatgatt attagaggct gacaacggta agaggggaggg gaggatatgg agaggttggt 106200 
           taaagaatat gaaattggag ccaaatatga ggaatgagtt ctagcattct gtagtactgt 106260 
           agggtgatat acttaacaat agtttattgc atatgttcaa aaatctagaa gagagaattt 106320 
           ttaattttta ctgttcccac cacaaaggaa tgataaatgt ttcaggtaat ggatatgtta 106380 
           attaccctaa tttgattatc acacattgta tacatgtatg gaaatataat tctggatccc 106440 
           acaattatat acaattatta catattcact aaaaataaaa gaaaaattaa aaatagagta 106500 
           gcatatgacc cagcaatccc tcttctgggt gtagatccac aagaaaagat ttcagcatat 106560 
           ctgtttccaa gggccccaac acagtggctc ttgcttggaa tcccagtgct ttgggaggct 106620 
           gaggcaggaa gatcacttat aactatataa ggaattttaa aaacactaaa actaatattt 106680 
           atttatttag caaaccagaa tttaaaacat tagaaattaa agtgttttat ttctttgtaa 106740 
           aaaacttatc aagagtaatg taaatagtgt ttgtcttctt ctcattgtat aacttcctat 106800 
           acggagtgga catgtttttt atattttaca gaattgtcat actctattct aaatttgaat 106860 
           taggagtttg agaccagtct gggcaacaga gtgagatgct atatctacaa aaaatattaa 106920 
           aaattagcca ggcatggtaa tgtatgcctg tagtctcagc tacttgggag gccaaggcag 106980 
           gaggatctct tgagcccaga agtttgaggt tacagtgagc tatgataaca ccactccatt 107040 
           gcagcctggg tgacagcaag accctgtctc caaaaaagaa aaaaagaaaa acataatagc 107100 
           cacaactaaa gtgtctactg atagataggt agataaaaag attgtggtac atagatacaa 107160 
           tggaatatca gtcagcccta aaaaaacaag atcctaccat ttacaacatg gatgaaccca 107220 
           gacaaaatta tgctaagtga aataagccaa aacacagaaag aaaaatatta cattatctca 107280 
           catatatgtg gaagcttgaa acaaaattca aatatacaga gactacgtaa aaaacagggt 107340 
           taataggggt ggaaaagtag gtagaaaata gggacatata ggccataggga tccaagcaag 107400 
           tagcagatgt gtaagatgaa aaagtgtaca gatctaatgt atgaggactg taggtgataa 107460 
           aattgtacta tatttgagat tcatgataaa taagtggatt ttagctgccc ttgccacaaa 107520 
           aacaacaaaa aaggtaacta tgagagatta tgaatatatt aatttgcttc aatatagtaa 107580 
           ttttttagtg tctaatgtat ctgatagcat catgttgcat accctaaata tacacaatta 107640 
           aatttatttt taaaaaagaa tgccactagg ccgggtgcaa tggctcacgc ctgtaatccc 107700 
           agcattttgg gaggccgagg tcggggatga tgagatcagg agttcgagac catcctggct 107760 
           aacatggtga aaccccatct ctactaaaaa tacaaaaatt agccgggcat ggtggtgcat 107820 
           gcctgtaatt tcagctactc aggaggctga gtcaggagaa taacttgaac ccaggaggcg 107880 
           gaggttgcag tgagccgaga tcacaccact gcacttcagc ctggagtgaa atgacagatt 107940 
           gagaccctat ctcagaaaaa aagaaaaaaa aaagaatgcc actaaaccac accattagaa 108000 
           cttataatta attatttttt ataaatatct tatgcaacat attttatatt tttgtagtgc 108060 
           aaccccaaag agataggtat ataacttaaa aaaacgagat aaatgagagt cctcataagg 108120 
           ttaccatgta tcaaaccaat cagttgttct ttgaggtcat aattatttac taataatctg 108180 
           taattgatgg ttagccttta atttatgagt aatctgtaat tgataacgta cacctacaaa 108240 
           ataggtgcca agtggttatg tgactagcaa ggtataaatg ctgtagggac accagagctg 108300 
           atggcttccc tgagcggagg tgtcccacac acaccctatc ttgtcttccc aacctcaaaa 108360 
           gagcacagag tggagaagaa ggtcagaagt aatacctgag agttttgaga actcagttat 108420 
           ccctgttgtg catgttatgt tgactttgtc agcttagtga ggtgaagcac attttgactt 108480 
           gagaatttgc tatcaatttc actgatggcc actgctgctt attgagcaga gtggcattgg 108540 
           aagacactca aagatcatca ttttcttgta tttattgcat ttatattact gagcattata 108600 
           taaagataat taaatctttc tgcttttgga tttagatcta attaatttct gagtcatttg 108660 
           aagaaatttt tgtctattaa attgaagtat gttgattgaa aattggtgta cgcagataac 108720 
           aaaaatggag ggaacaaaac ccataaaaat aacactgatc attaaggtag ttcttcaatg 108780 
           agttaaaaag tagttgttaa aagtatattc ttataaagga atgagattac ttttcttatg 108840 
           aggcttctac caaacatctt cagccataag tgaaattata aaatggtctt tggtcgcctc 108900 
           caatctttca aactagttat gtaatgaagg ataaaagaat aaatggaaaa cgtgttggca 108960 
           aagtaattat tccgttggag agtttatttg ataataataa ccatggttcc tatatataaa 109020 
           agtgtgctca attattcata tgtcctgtct tattatgaca ttcccacaaa aactgcaagg 109080 
           tagttgcagt tttctaaatc atatttttta ctaatcaggg aagtgatgct cagagatgtt 109140 
           aagtacgctt ccccaagacc ctaaaggtga taagtgatgt agtctcaact aaaactttgg 109200 
           tttgtgtgat tagtgcatgt tctttccact ctatcagtag tcagcaagct acaacataca 109260 
           agacaattcc agcccaccac ctgttttgat aaatgaagtt ttatgggac acagccacac 109320 
           tagttatgtgt ttatgactac cttcacactt caacagcaga attgagacat agattttttt 109380 
           ttcttttttt tagacagggt atcactctgc cacccaggct ggagtgcagt ggctcgatct 109440 
           cagctcactg caacctctgc agtgagctgt atggctcaag ccatcctcct acctcagcct 109500 
           cctgggtagc tggcaataca catgcatgct accatacccg gctaattttt gcgttgtttg 109560 
           tagacacagg gtttcaccat gtggcccagg ctggtctcaa acccctgggc tcaagtgatc 109620 
           caccagcctc gggctctcaa agtgctggga ttaaagacct gagccacggc acctggccaa 109680 
           gacatagatc tcatggctta aaatacgtgc tatctgattc cttacccaaa attttgccaa 109740 
           tccctggact atactattgt gtcttcacat ggtcattttt tatcttaaat tctgtgtgta 109800 
           agttcaactc tcaattagaa ctcagaatgt aaccaataaa aaatttatag aatgtgctat 109860 
           gtgttaaatg ccatgagaga cattgaaaat gatttcaatg aacagttaaa aggtaactaa 109920 
           gtcaaagaaa cttgtgcttg cagaacttgg aaatctgagg acaaacggaa agatattgat 109980 
           aaactgcatg tcactgattc agtattccaa attccatcta aaaaggtata attcacactt 110040 
           cataaaatat ttaaaattaa ctcatcaatt ttttcctctt gtaacaccct atttcaatga 110100 
           ctttctgaaa atatgtttta aggtagaaaa aaagtaattt aattgaagat ttgtgggaag 110160 
           attaagtcaa cataagaaaa gtctaaataa tgaggcagtg gcacatgcct ataatcctgg 110220 
           ctactcagga ggctgaggtg ggggcatgac ttgagcccag gaattcaagg atgcagtgag 110280 
           ctatgatagc atcactgcag tccagcctgg gcgacagagc aaggccctga ctctaaaaac 110340 
           tgaaaataaa aaactgaaaa aaaaatgtgt tgtgaacttt gatgagatgc attcatataa 110400 
           atcatcccaa gtataaaatt tcccccactg atctatgttg aagagatagt gtagctttct 110460 
           ttcactttgc agacatagac ggagcacatg tttcagctag gcaactcaat gtggtcatcc 110520 
           tccacctgac tgttcatcct gtgactctta ctgctatagt tgccaccaga gaatgtgaaa 110580 
           aagctcagag gagaaagaag agaggaagaa tgggcaatgt gtctgtgttg agtgtgtgtg 110640 
           tctatgcctg tggatgagag tgtgtgtcta ttcttttcca aggaattcaa agtggtttgt 110700 
           aaaataacac tcaattgaat acagttcaag ttacagaaaa gagagtcaga gtttgggtgt 110760 
           ataccccaag gtggaacttt aggaacaagt aggtaataag catcaatttc tttattcttt 110820 
           tagtatgtgtgtcatttgat ggatgaacta tacaaatgtt tctgagagat tagtagcagc 110880 
           cctcaagcac ttttctctgt cctcagtgtt cacagagacc aaatgatcac atgaagtaac 110940 
           tctatcaaag actaatctgt tctttccatt ttagggccac aaataggtct ctttatacac 111000 
           atcacagggg catatcaaag tcatatttta aaaatcagaa tggattaaaa ttgacaaaca 111060 
           tttttcatga tggtaaaaga aatcacagat ccatcaatga ttttgattct taagaatatt 111120 
           cttgattatt ttttaaaaga ctatgagttt ttaaaactgt tctctgaaat agaattatgt 111180 
           aggtacagaa acattcatt ttaaaaagtc ataaatatta gggcaaaatt aaaaatctgg 111240 
           aaaagcaaac agtcgcattt tttactatta gctcaaatac acacgttcac attcacctac 111300 
           ctacacatac ctctgactca gtccaccttt ttgacaagca atgatgcaaa aatgaatcaa 111360 
           gagagagaac taccagcatt tagagtattg attatcctaa cccatcactc atgaacaagc 111420 
           accaaactga catttggggt ttacctacct acatagagaa caccctcttt tgtctttcct 111480 
           gctgcttctg ccacaccctg tttggttttc tcagcagcag ccacaactcc ctccttggcc 111540 
           tttgaaagtc ctttcatgaa tacatccatg gctaatgaat tcctttacac cacactggaa 111600 
           aacataaaat acactttgaa tgagaacttt cggggaaaaa taaacaaaaa acactgaaaa 111660 
           atcatgagaa accctccaaa gtgtgagact cttttaagtg tacactcatt taaccattgg 111720 
           acaaagcaga catttttagc tctggcatta aaaatttagc atctcccatc catcttggct 111780 
           agtaaaagtc tagccaccta accacggatt aggatgaatc ctctgagttg ttaattactgc 111840 
           atttcagaag tggagttgca tgaaaagatt aacccctttt ttaaattccc ggggtctaaa 111900 
           gggtaacagt atgagttaga agcatggaag ctggaggctt agggtcaggg gtatccttaa 111960 
           catgaatccc agaagaaggc taacaggttg atggtggaaa ggcgtaggca acagaactaa 112020 
           ctgctcactc ggggtgtggt tcaaactcag gcaaacagca ggcccaagtg tgatggttct 112080 
           aatccatcca acatccacccc ccgccctcag ctatctaccc tgagcaggcg ccgctcacac 112140 
           tcgcgggccg tctccaaccc cgcgccagcc acccgagggg gcgttctcag cctccaccct 112200 
           agcggaccccc gcgccagcac ttgttaaccc gttaccacct gttgacttgg cctccttgca 112260 
           cttccatttc attatttgcc aaacgcagct tgcttacttt acagagaaaa accaagagag 112320 
           cgggcagaca gattttatgt gagagaaaag ttggatgctc acgctccatg gagcatcctc 112380 
           gcgtttcccg gggaaaagcg gatcccggag aagcagccta atctctcagc ccttgtggag 112440 
           aagggaatat cagaagcagg acgaaagcca ggtcaagtct ctttccttag gctccccaaa 112500 
           gggacaagta ctcacctccc agagacctgg cccagcgggt cctcatggca gcaccacccc 112560 
           ctcccggtgc ccacgaccat tcgtctccca tccggcgttc tccaggattt ccaaagacgc 112620 
           ccgtttagat ccacaggtac ttacctgagt ccctctgctt ctccacaact ccgactcctc 112680 
           cccgcctctc tcttttttta aaaaaaaaat ttaaacaatt cccaaataat atttaatagg 112740 
           aaagaagaag gaaaaggagc gcacaggaag ggcggaggcg gcacccgggg gggactgtcc 112800 
           ccagaggagg ccgctgtgag ccggcgacgc gaggctgggg gagtgggagg caaacccgct 112860 
           aacctgtcgt cgaatggcca ctcccagttc tccgctcacg agggtggaaa ggcagaaggc 112920 
           ttgaaggcaa ggcgtgaggg agcgcccagg acgctctcgg aggggccggg ccggggtctg 112980 
           cgctgcagcc cgcacgcacc tcacttccgc gtcgcggcgc tcggtcgctc gccccctctc 113040 
           ttgggcccct tctggtcgtc gccgtcctcc tcctcctagt cctcctcctt ctccttctcc 113100 
           tcggctctcc gcccccaccg ctgatttgtc agcgcttctg cccgcccctc tcccggcgct 113160 
           cgctgctttc cctgcagcgt gctcctcgtc cctatctcgg atggggatgg ggcaggggggc 113220 
           gcggggtgag ccatcaactc cagccgcctg cctggccgcg caaggcggga aagtgggggc 113280 
           gcttttgcgc ctcacgttaa gtttagggtc acgagcactc ttgtggagat cgggagcggt 113340 
           tgggctaggg atgatgcctc ttcctctttc cccttcccct cccttcttgt ccccgccttt 113400 
           cctctgggtc ctcccgggga ccaccccccta cccctcgtca gagtcgccct gggagagccg 113460 
           agggcctgag ggtcgaccac caagggcaga gcctatccct tggggagctg ctggaggaga 113520 
           caggcagcgc cgggaggtgg ctcacaccgc accgccgaga gcgctttgcc ctcgcatcgc 113580 
           tgaaatttaa tcacggtcac aggttacaac gttaggggtc gctttagttc aaatatcttc 113640 
           aaggttttcg tttgctctta atctaggaag agccggaaag ggtcctgagg gtgaaaggga 113700 
           gactactaag gaagagtcac aggttgagga ggcaggagaa ggctcagcaa atcctctttc 113760 
           cacgccacta tcaccatttt cctttccacc aatcagcgcc tgccagacgc tgattttccc 113820 
           atcagtggaa caaggaataa atattcccca gccgtctaaa acaagcggtc ctaaggcttt 113880 
           tcgctctaga aatgggactt actttgcaga cctcccttta tctgggagac aaatccagcg 113940 
           tgatttagcc taccggacca tcatatccaa tttcttcttc agccccttct gaaagggaga 114000 
           tgctacacac cactcacctt tctgacttct gattctcgtt gccctcagaa ttgacacccc 114060 
           cttttctctc cccccaccca ccacacgcac atgcacacag acatacacac gcgaacttca 114120 
           agacaatttt tgcatcgctt aacacatttt cacctctttc agagctggaa gacagctgtt 114180 
           cctggatcac accagaatgg agaagcaagc tcctcccact agcaga 114226 
            <![CDATA[ <210> 3]]>
           <![CDATA[ <211> 423]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Sapiens]]>
           <![CDATA[ <400> 3]]>
          atggatgtat tcatgaaagg actttcaaag gccaaggagg gagttgtggc tgctgctgag 60
          aaaaccaaac agggtgtggc agaagcagca ggaaagacaa aagagggtgt tctctatgta 120
          ggctccaaaa ccaaggaggg agtggtgcat ggtgtggcaa cagtggctga gaagaccaaa 180
          gagcaagtga caaatgttgg aggagcagtg gtgacgggtg tgacagcagt agcccagaag 240
          acagtgggagg gagcagggag cattgcagca gccactggct ttgtcaaaaa ggaccagttg 300
          ggcaagaatg aagaaggagc cccacaggaa ggaattctgg aagatatgcc tgtggatcct 360
          gacaatgagg cttatgaaat gccttctgag gaagggtatc aagactacga acctgaagcc 420
          taa 423
           <![CDATA[ <210> 4]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 4]]>
          gcagttctat cccactcatc 20
           <![CDATA[ <210> 5]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 5]]>
          aatagcatcc ttccacacca 20
           <![CDATA[ <210> 6]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 6]]>
          atcaccttca aacccctttc 20
           <![CDATA[ <210> 7]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> DN]]>A
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 7]]>
          ccggtgccat tactcccttt 20
           <![CDATA[ <210> 8]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 8]]>
          ttgcagataa accatcccac 20
           <![CDATA[ <210> 9]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 9]]>
          agtgccagac cctttcatta 20
           <![CDATA[ <210> 10]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 10]]>
          ccaagtgcca gaccctttca 20
           <![CDATA[ <210> 11]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 11]]>
          gcagataaac catcccactt 20
           <![CDATA[ <210> 12]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 12]]>
          gaactgatgc ctctacctcc 20
           <![CDATA[ <210> 13]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 13]]>
          actga actga tgcctctacc 20
           <![CDATA[ <210> 14]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 14]]>
          tacatggcca gaaaccactt 20
           <![CDATA[ <210> 15]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 15]]>
          aagccaagcc caaacactaa 20
           <![CDATA[ <210> 16]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 16]]>
          tccaaaggag caccaaccaa 20
           <![CDATA[ <210> 17]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 17]]>
          cggtgccatt actccctttc 20
           <![CDATA[ <210> 18]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feat]]>ure
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <400> 18]]>
          gcagttctat cccactcatc 20
           <![CDATA[ <210> 19]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <22]]>3> Phosphodiester internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(18)..(18)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-MOE modified ribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(18)..(19)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(19)..(19)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 5-methylcytosine BNA]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(19)..(20)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(20)..(20)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;BNA]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;400&gt;19]]&gt;
           <br/> <![CDATA[aatagcatcc ttccacacca 20
           <![CDATA[ <210> 20]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-]]>deoxyribose
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc]]>_feature
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> phosphate]]> diester internucleoside linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <400> 20]]>
          atcaccttca aacccctttc 20
           <![CDATA[ <210> 21]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..]]>(2)
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223]]>> phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(10)..(10)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(10)..(11)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(11)..(11)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(11)..(12)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(12)..(12)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(12)..(13)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;]]&gt; <![CDATA[ phosphorothioate internucleoside linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 21]]>
          ccggtgccat tactcccttt 20
           <![CDATA[ <210> 22]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223>phosphorothioate]]>ester internucleoside linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> mis]]>c_feature
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <400> 22]]>
          ttgcagataa accatcccac 20
           <![CDATA[ <210> 23]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (]]>13)..(13)
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> ]]>2'-deoxyribose
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 23]]>
          agtgccagac cctttcatta 20
           <![CDATA[ <210> 24]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 24]]>
          ccaagtgcca gaccctttca 20
           <![CDATA[ <210> 25]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> mis]]>c_feature
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> phosphorothioate]]> ester internucleoside linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_featur]]>e
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 25]]>
          gcagataaac catcccactt 20
           <![CDATA[ <210> 26]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2']]>-MOE modified ribose
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223>]]> Phosphorothioate internucleoside linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feat]]>ure
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_f]]>eature
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <400> 26]]>
          cggtgccatt actccctttc 20
           <![CDATA[ <210> 27]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc]]>_feature
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15).]]>.(15)
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5]]>-Methylcytosine BNA
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <400> 27]]>
          gaactgatgc ctctacctcc 20
           <![CDATA[ <210> 28]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_]]>feature
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> ]]>2'-Deoxyribose 5-methylcytosine
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <400> 28]]>
          actga actga tgcctctacc 20
           <![CDATA[ <210> 29]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_fe]]>ature
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 29]]>
          tacatggcca gaaaccactt 20
           <![CDATA[ <210> 30]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_fea]]>ture
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> ]]>(4)..(4)
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)]]>..(8)
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <22]]>3> 2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(13)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(1]]&gt; <![CDATA[5)
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 30]]>
          aagccaagcc caaacactaa 20
           <![CDATA[ <210> 31]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> ]]>(3)..(4)
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9]]>)..(10)
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> BNA]]>
           <![CDATA[ <400> 31]]>
          tccaaaggag caccaaccaa 20
           <![CDATA[ <210> 32]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> mis]]>c_feature
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <400> 32]]>
          gcagttctat cccactcatc 20
           <![CDATA[ <210> 33]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223>]]> 5-Methylcytosine LNA
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 33]]>
          aatagcatcc ttccacacca 20
           <![CDATA[ <210> 34]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_f]]>eature
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxy]]>ribose 5-methylcytosine
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <400> 34]]>
          atcaccttca aacccctttc 20
           <![CDATA[ <210> 35]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc]]>_feature
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 35]]>
          ccggtgccat tactcccttt 20
           <![CDATA[ <210> 36]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17]]>)..(18)
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <400> 36]]>
          ttgcagataa accatcccac 20
           <![CDATA[ <210> 37]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)]]>..(8)
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223]]>> phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(15)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(15)..(15)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(15)..(16)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(16)..(16)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-]]&gt; <![CDATA[MOE modified ribose 5-methylcytosine
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 37]]>
          agtgccagac cctttcatta 20
           <![CDATA[ <210> 38]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxy]]>ribose
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-Deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 38]]>
          ccaagtgcca gaccctttca 20
           <![CDATA[ <210> 39]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223>phosphorothioate]]>ester internucleoside linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <22]]>1> mis]]&gt; <![CDATA[c_feature
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 39]]>
          gcagataaac catcccactt 20
           <![CDATA[ <210> 40]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> ]]>(1)..(1)
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> phosphorothioate internucleoside bond]]> link
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13]]>)
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_]]>feature
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <400> 40]]>
          cggtgccatt actccctttc 20
           <![CDATA[ <210> 41]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2']]>-deoxyribose
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_fea]]>ture
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <400> 41]]>
          gaactgatgc ctctacctcc 20
           <![CDATA[ <210> 42]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> person]]> work sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220]]>>]]>
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(7)..(7)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-Deoxyribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(7)..(8)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(8)..(8)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(8)..(9)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(9)..(9)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(9)..(10)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(10)..(10)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(10)..(11)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(11)..(11)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(11)..(12)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(12)..(12)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(12)..(13)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(13)..(13)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-Deoxyribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(13)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-Deoxyribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(15)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(15)..(15)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(15)..(16)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(16)..(16)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-MOE modified ribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(16)..(17)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphodiester internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(17)..(17)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2']]&gt; <![CDATA[-MOE Modified Ribose
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <400> 42]]>
          actga actga tgcctctacc 20
           <![CDATA[ <210> 43]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> phosphorothioate internucleoside]]> linkage
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222]]>> (12)..(13)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(13)..(13)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(13)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(14)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;2'-deoxyribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(14)..(15)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(15)..(15)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-Deoxyribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(15)..(16)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(16)..(16)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-MOE modified ribose 5-methylcytosine]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(16)..(17)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphodiester internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(17)..(17)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 2'-MOE modified ribose]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(17)..(18)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(18)..(18)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; 5-methylcytosine LNA]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(18)..(19)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphodiester internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(19)..(19)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;LNA]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(19)..(20)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Phosphorothioate internucleoside linkage]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;221&gt;misc_feature]]&gt;
           <br/> &lt;![CDATA[ &lt;222&gt;(20)..(20)]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt;LNA]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;400&gt;43]]&gt;
           <br/> <![CDATA[tacatggcca gaaaccactt 20
           <![CDATA[ <210> 44]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 44]]>
          aagccaagcc caaacactaa 20
           <![CDATA[ <210> 45]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (4)..(5)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (5)..(6)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (6)..(7)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (8)..(9)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(9)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (9)..(10)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(10)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (10)..(11)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(11)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (11)..(12)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(12)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (12)..(13)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(13)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (13)..(14)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(14)]]>
           <![CDATA[ <223> 2'-deoxyribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (14)..(15)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(15)]]>
           <![CDATA[ <223> 2'-deoxyribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (15)..(16)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(16)]]>
           <![CDATA[ <223> 2'-MOE modified ribose]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (16)..(17)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(17)]]>
           <![CDATA[ <223> 2'-MOE modified ribose 5-methylcytosine]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (17)..(18)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(18)]]>
           <![CDATA[ <223> 5-Methylcytosine LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (18)..(19)]]>
           <![CDATA[ <223> Phosphodiester internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(19)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (19)..(20)]]>
           <![CDATA[ <223> Phosphorothioate internucleoside linkage]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> misc_feature]]>
           <![CDATA[ <222> (20)..(20)]]>
           <![CDATA[ <223> LNA]]>
           <![CDATA[ <400> 45]]>
          tccaaaggag caccaaccaa 20
           <![CDATA[ <210> 46]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequences: Synthetic Peptides]]>
           <![CDATA[ <400> 46]]>
          Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys
          1 5 10 15
           <![CDATA[ <210> 47]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequences: Synthetic Peptides]]>
           <![CDATA[ <400> 47]]>
          Thr Val Glu Gly Ala Gly Asn Ile Ala Ala Ala Thr Gly Phe Val Lys
          1 5 10 15
           <![CDATA[ <210> 48]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequences: Synthetic Peptides]]>
           <![CDATA[ <400> 48]]>
          Val Gly Val Asn Gly Phe Gly Arg
          1 5
           <![CDATA[ <210> 49]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 49]]>
          cgtagtcttg atacccttcc 20
           <![CDATA[ <210> 50]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 50]]>
          gttcgtagtc ttgataccct 20
           <![CDATA[ <210> 51]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 51]]>
          ggttcgtagt cttgataccc 20
           <![CDATA[ <210> 52]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 52]]>
          aggttcgtag tcttgatacc 20
           <![CDATA[ <210> 53]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 53]]>
          caggttcgta gtcttgatac 20
           <![CDATA[ <210> 54]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 54]]>
          ttcaggttcg tagtcttgat 20
           <![CDATA[ <210> 55]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <21]]>3> Artificial sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 55]]>
          gctatgaccc tcaagccatc 20
           <![CDATA[ <210> 56]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 56]]>
          caactaacca cggcacaatt 20
           <![CDATA[ <210> 57]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 57]]>
          tagccgacat acatctccaa 20
           <![CDATA[ <210> 58]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 58]]>
          gtaaatatgt cagtctcccg 20
           <![CDATA[ <210> 59]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 59]]>
          gggttctcta acgacagtag 20
           <![CDATA[ <210> 60]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 60]]>
          ggggttctct aacgacagta 20
           <![CDATA[ <210> 61]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 61]]>
          ggatggggtt ctctaacgac 20
           <![CDATA[ <210> 62]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 62]]>
          gagcgatcgg aagctccctg 20
           <![CDATA[ <210> 63]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 63]]>
          agagcgatcggaagctccct 20
           <![CDATA[ <210> 64]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 64]]>
          gttgctatct agggatcacc 20
           <![CDATA[ <210> 65]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 65]]>
          gcgaaggact atataatagg 20
           <![CDATA[ <210> 66]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 66]]>
          ggta acttag gacaaggtcc 20
           <![CDATA[ <210> 67]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 67]]>
          ttcacataaa gtagccgcta 20
           <![CDATA[ <210> 68]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 68]]>
          acttcacata aagtagccgc 20
           <![CDATA[ <210> 69]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 69]]>
          atagccgaca tacatctcca 20
           <![CDATA[ <210> 70]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 70]]>
          gacggatcagacactcttac 20
           <![CDATA[ <210> 71]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 71]]>
          tgcctcacgg atgtccgtgt 20
           <![CDATA[ <210> 72]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 72]]>
          gctcgagatt agttcttccc 20
           <![CDATA[ <210> 73]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 73]]>
          gccactagta gatgacagtt 20
           <![CDATA[ <210> 74]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 74]]>
          gatggaattt accccctagt 20
           <![CDATA[ <210> 75]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 75]]>
          agcagaagca tgcggctacc 20
           <![CDATA[ <210> 76]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 76]]>
          ggtatcgtca tggaatttgg 20
           <![CDATA[ <210> 77]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 77]]>
          gatctaagga ccctcaacaa 20
           <![CDATA[ <210> 78]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 78]]>
          ggatctaagg acccctcaaca 20
           <![CDATA[ <210> 79]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 79]]>
          actctatctt gaggcacacc 20
           <![CDATA[ <210> 80]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 80]]>
          ctgttaatgt agtaggagca 20
           <![CDATA[ <210> 81]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 81]]>
          actgttaatg tagtaggagc 20
           <![CDATA[ <210> 82]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 82]]>
          tttggggttt acctacctac 20
           <![CDATA[ <210> 83]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 83]]>
          tactgactgt ccaagggtgt 20
           <![CDATA[ <210> 84]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 84]]>
          tcagggcaag ggtatgcttg 20
           <![CDATA[ <210> 85]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 85]]>
          tccagtcagg tggtgtatga 20
           <![CDATA[ <210> 86]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 86]]>
          atggggttct ctaacgacag 20
           <![CDATA[ <210> 87]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 87]]>
          tggatggggt tctctaacga 20
           <![CDATA[ <210> 88]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 88]]>
          aagagcgatc ggaagctccc 20
           <![CDATA[ <210> 89]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 89]]>
          ttttcaagag cgatcggaag 20
           <![CDATA[ <210> 90]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 90]]>
          ctagcgaagg actatataat 20
           <![CDATA[ <210> 91]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 91]]>
          ctatcttacg tggctatatc 20
           <![CDATA[ <210> 92]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 92]]>
          aagtagccgc tactgcttaa 20
           <![CDATA[ <210> 93]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 93]]>
          tctggacagg cgcttatcta 20
           <![CDATA[ <210> 94]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 94]]>
          gatggagtac ctacca actt 20
           <![CDATA[ <210> 95]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 95]]>
          acacgtggcc agatcaatcc 20
           <![CDATA[ <210> 96]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 96]]>
          ctacacacgt ggccagatca 20
           <![CDATA[ <210> 97]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 97]]>
          actacacacg tggccagatc 20
           <![CDATA[ <210> 98]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 98]]>
          tttgggcatg actacacacg 20
           <![CDATA[ <210> 99]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 99]]>
          atgggccatt ggcaatcaag 20
           <![CDATA[ <210> 100]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 100]]>
          cctgcctcac ggatgtccgt 20
           <![CDATA[ <210> 101]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 101]]>
          tcctgcctca cggatgtccg 20
           <![CDATA[ <210> 102]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 102]]>
          cataagatcg attaagtgga 20
           <![CDATA[ <210> 103]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> ]]> Description of Artificial Sequence: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 103]]>
          acataagatc gattaagtgg 20
           <![CDATA[ <210> 104]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 104]]>
          tacataagat cgattaagtg 20
           <![CDATA[ <210> 105]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 105]]>
          attaggcctg attagctaaa 20
           <![CDATA[ <210> 106]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 106]]>
          tatctgtaac cacgccctta 20
           <![CDATA[ <210> 107]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 107]]>
          gaagcatgcg gctaccatgc 20
           <![CDATA[ <210> 108]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 108]]>
          aagcagaagc atgcggctac 20
           <![CDATA[ <210> 109]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 109]]>
          tataaatctt cagggactcg 20
           <![CDATA[ <210> 110]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 110]]>
          tggttcgata atagctaagc 20
           <![CDATA[ <210> 111]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 111]]>
          cgtcatggaa tttggtctgt 20
           <![CDATA[ <210> 112]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 112]]>
          gggattcatc tggcattagg 20
           <![CDATA[ <210> 113]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 113]]>
          atgctaagcc aaacctagca 20
           <![CDATA[ <210> 114]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 114]]>
          cagtagacca ctgatgatct 20
           <![CDATA[ <210> 115]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 115]]>
          tagagtgaca ggtctggtac 20
           <![CDATA[ <210> 116]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 116]]>
          gggagtgtgt acatagtgta 20
           <![CDATA[ <210> 117]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 117]]>
          gccatactag ttatgaca 18
           <![CDATA[ <210> 118]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 118]]>
          aaccggtgcc attackcc 18
           <![CDATA[ <210> 119]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 119]]>
          cttcatatac gagttgac 18
           <![CDATA[ <210> 120]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 120]]>
          ggatggggtt ctctaacg 18
           <![CDATA[ <210> 121]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 121]]>
          gtagttagag tgtagttg 18
           <![CDATA[ <210> 122]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 122]]>
          agcgatcgga agctccct 18
           <![CDATA[ <210> 123]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 123]]>
          ttttcaagag cgatcgga 18
           <![CDATA[ <210> 124]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 124]]>
          gttttcaaga gcgatcgg 18
           <![CDATA[ <210> 125]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 125]]>
          tgttttcaag agcgatcg 18
           <![CDATA[ <210> 126]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 126]]>
          gaccctcaag ccatctag 18
           <![CDATA[ <210> 127]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 127]]>
          gctatgaccc tcaagcca 18
           <![CDATA[ <210> 128]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 128]]>
          atggttgccc agaagtta 18
           <![CDATA[ <210> 129]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 129]]>
          aactaaccac ggcacaat 18
           <![CDATA[ <210> 130]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 130]]>
          gactatataa taggctca 18
           <![CDATA[ <210> 131]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 131]]>
          ctagcgaagg actatata 18
           <![CDATA[ <210> 132]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 132]]>
          gctagcgaag gactatat 18
           <![CDATA[ <210> 133]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 133]]>
          tgctagcgaa ggactata 18
           <![CDATA[ <210> 134]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 134]]>
          tgaatagcct ttgtaggt 18
           <![CDATA[ <210> 135]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 135]]>
          taacccctttacagatcc 18
           <![CDATA[ <210> 136]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 136]]>
          actgtggatg aaggttac 18
           <![CDATA[ <210> 137]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 137]]>
          tggacaggcg cttatcta 18
           <![CDATA[ <210> 138]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 138]]>
          ctggacaggc gcttatct 18
           <![CDATA[ <210> 139]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 139]]>
          ctaggggtac aacagggt 18
           <![CDATA[ <210> 140]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 140]]>
          gttggctgcc caacttac 18
           <![CDATA[ <210> 141]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 141]]>
          taatagccga catacatc 18
           <![CDATA[ <210> 142]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 142]]>
          ttttaatagc cgacatac 18
           <![CDATA[ <210> 143]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 143]]>
          tatacccctg gcatacata 18
           <![CDATA[ <210> 144]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 144]]>
          atctacagac acggcttt 18
           <![CDATA[ <210> 145]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 145]]>
          atttttgacg gatcagac 18
           <![CDATA[ <210> 146]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 146]]>
          tagtttgggt ccatgcca 18
           <![CDATA[ <210> 147]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400>]]> 147
          gaggggtgct tttaagcc 18
           <![CDATA[ <210> 148]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 148]]>
          atgctcgaga ttagttct 18
           <![CDATA[ <210> 149]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 149]]>
          gaagcatgcg gctaccat 18
           <![CDATA[ <210> 150]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 150]]>
          gttcgataat agctaagc 18
           <![CDATA[ <210> 151]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 151]]>
          aacatcgcct cagtcaat 18
           <![CDATA[ <210> 152]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 152]]>
          ggtatcgtca tggaattt 18
           <![CDATA[ <210> 153]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 153]]>
          cttaagaggc ttatatag 18
           <![CDATA[ <210> 154]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 154]]>
          aattaaacga gagtctca 18
           <![CDATA[ <210> 155]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 155]]>
          taattgcatc ctagtaag 18
           <![CDATA[ <210> 156]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 156]]>
          acctgtaggg ttgaatag 18
           <![CDATA[ <210> 157]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 157]]>
          aatccacagc tatagtcc 18
           <![CDATA[ <210> 158]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 158]]>
          ggggaaacat tgcggcaa 18
           <![CDATA[ <210> 159]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 159]]>
          cgtagtcttg ataccctt 18
           <![CDATA[ <210> 160]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 160]]>
          ttcgtagtct tgataccc 18
           <![CDATA[ <210> 161]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 161]]>
          gttcgtagtc ttgatacc 18
           <![CDATA[ <210> 162]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 162]]>
          tcatatacga gttgac 16
           <![CDATA[ <210> 163]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 163]]>
          ggggttctct aacgac 16
           <![CDATA[ <210> 164]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 164]]>
          tggggttctc taacga 16
           <![CDATA[ <210> 165]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 165]]>
          atggggttct ctaacg 16
           <![CDATA[ <210> 166]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 166]]>
          cgatcggaag ctccct 16
           <![CDATA[ <210> 167]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 167]]>
          gcgatcggaa gctccc 16
           <![CDATA[ <210> 168]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 168]]>
          gagcgatcgg aagctc 16
           <![CDATA[ <210> 169]]>
           <![CDATA[ <211> ]]>16
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 169]]>
          ttcaagagcg atcgga 16
           <![CDATA[ <210> 170]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 170]]>
          tttcaagagc gatcgg 16
           <![CDATA[ <210> 171]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 171]]>
          ctttagagta tacgga 16
           <![CDATA[ <210> 172]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 172]]>
          cctttagagt atacgg 16
           <![CDATA[ <210> 173]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 173]]>
          ccacggcaca atttga 16
           <![CDATA[ <210> 174]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 174]]>
          tacaactaac cacggc 16
           <![CDATA[ <210> 175]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 175]]>
          ctagcgaagg actata 16
           <![CDATA[ <210> 176]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 176]]>
          gctagcgaag gactat 16
           <![CDATA[ <210> 177]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 177]]>
          tgctagcgaa ggacta 16
           <![CDATA[ <210> 178]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 178]]>
          cgtggctata tcacta 16
           <![CDATA[ <210> 179]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 179]]>
          tactatctta cgtggc 16
           <![CDATA[ <210> 180]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 180]]>
          agccgctact gcttaa 16
           <![CDATA[ <210> 181]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 181]]>
          tagccgctac tgctta 16
           <![CDATA[ <210> 182]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> person]]> work sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 182]]>
          cacataaagt agccgc 16
           <![CDATA[ <210> 183]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 183]]>
          tggacaggcg cttatc 16
           <![CDATA[ <210> 184]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 184]]>
          ttaatagccg acatac 16
           <![CDATA[ <210> 185]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 185]]>
          cgattaatca actggc 16
           <![CDATA[ <210> 186]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> ]]>186
          cggatgtccg tgtgtg 16
           <![CDATA[ <210> 187]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 187]]>
          gatcgattaa gtggag 16
           <![CDATA[ <210> 188]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 188]]>
          aagatcgatt aagtgg 16
           <![CDATA[ <210> 189]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 189]]>
          gctcgagatt agttct 16
           <![CDATA[ <210> 190]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 190]]>
          tgctcgagat tagttc 16
           <![CDATA[ <210> 191]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 191]]>
          atatgctcgagattag 16
           <![CDATA[ <210> 192]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 192]]>
          tgtaaccacg ccctta 16
           <![CDATA[ <210> 193]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 193]]>
          gaagcatgcg gctacc 16
           <![CDATA[ <210> 194]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 194]]>
          tcgataatag ctaagc 16
           <![CDATA[ <210> 195]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 195]]>
          ggttcgataa tagcta 16
           <![CDATA[ <210> 196]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 196]]>
          gcggcaacat gggtta 16
           <![CDATA[ <210> 197]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 197]]>
          acattgcggc aacatg 16
           <![CDATA[ <210> 198]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 198]]>
          gaaacattgc ggcaac 16
           <![CDATA[ <210> 199]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 199]]>
          cgtagtcttg ataccc 16
           <![CDATA[ <210> 200]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 200]]>
          tcgtagtctt gatacc 16
           <![CDATA[ <210> 201]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 201]]>
          gcttcaggtt cgtagt 16
           <![CDATA[ <210> 202]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 202]]>
          gatacggtca ttcagta 17
           <![CDATA[ <210> 203]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 203]]>
          cttcatatac gagttga 17
           <![CDATA[ <210> 204]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212> D]]>NA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223>]]> Description of Artificial Sequence: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 204]]>
          gggttctcta acgacag 17
           <![CDATA[ <210> 205]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 205]]>
          tggggttctc taacgac 17
           <![CDATA[ <210> 206]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 206]]>
          atggggttct ctaacga 17
           <![CDATA[ <210> 207]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 207]]>
          gcgatcggaa gctccct 17
           <![CDATA[ <210> 208]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 208]]>
          agcgatcgga agctccc 17
           <![CDATA[ <210> 209]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 209]]>
          gagcgatcgg aagctcc 17
           <![CDATA[ <210> 210]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 210]]>
          ttcaagagcg atcggaa 17
           <![CDATA[ <210> 211]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 211]]>
          ttttcaagag cgatcgg 17
           <![CDATA[ <210> 212]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 212]]>
          gttttcaaga gcgatcg 17
           <![CDATA[ <210> 213]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 213]]>
          gttgctatct agggatc 17
           <![CDATA[ <210> 214]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 214]]>
          accacggcac aatttga 17
           <![CDATA[ <210> 215]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 215]]>
          ctagcgaagg actatat 17
           <![CDATA[ <210> 216]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 216]]>
          gctagcgaag gactata 17
           <![CDATA[ <210> 217]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 217]]>
          tgctagcgaa ggactat 17
           <![CDATA[ <210> 218]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 218]]>
          acgtggctat atcacta 17
           <![CDATA[ <210> 219]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 219]]>
          gccaggcgag aatttgc 17
           <![CDATA[ <210> 220]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 220]]>
          ctggacaggc gcttatc 17
           <![CDATA[ <210> 221]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 221]]>
          tctggacagg cgcttat 17
           <![CDATA[ <210> 222]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 222]]>
          acgtggccag atcaatc 17
           <![CDATA[ <210> 223]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 223]]>
          atctacagac acggctt 17
           <![CDATA[ <210> 224]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 224]]>
          gcctcacgga tgtccgt 17
           <![CDATA[ <210> 225]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 225]]>
          agatcgatta agtggag 17
           <![CDATA[ <210> 226]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 226]]>
          ataagatcga ttaagtg 17
           <![CDATA[ <210> 227]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 227]]>
          gcgtatgggc atctcca 17
           <![CDATA[ <210> 228]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 228]]>
          tgcgtatggg catctcc 17
           <![CDATA[ <210> 229]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 229]]>
          ctttctgcgt atgggca 17
           <![CDATA[ <210> 230]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 230]]>
          gctttctgcg tatgggc 17
           <![CDATA[ <210> 231]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 231]]>
          gacctccatc agtagta 17
           <![CDATA[ <210> 232]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 232]]>
          tcgagattag ttcttcc 17
           <![CDATA[ <210> 233]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 233]]>
          ctcgagatta gttcttc 17
           <![CDATA[ <210> 234]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 234]]>
          gctcgagatt agttctt 17
           <![CDATA[ <210> 235]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 235]]>
          tgctcgagat tagttct 17
           <![CDATA[ <210> 236]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 236]]>
          tatctgtaac cacgccc 17
           <![CDATA[ <210> 237]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 237]]>
          tgcggctacc atgctac 17
           <![CDATA[ <210> 238]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 238]]>
          gcatgcggct accatgc 17
           <![CDATA[ <210> 239]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> ]]>Artificial sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 239]]>
          gttcgataat agctaag 17
           <![CDATA[ <210> 240]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 240]]>
          ggttcgataa tagctaa 17
           <![CDATA[ <210> 241]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 241]]>
          gaagagatgg ttcgata 17
           <![CDATA[ <210> 242]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 242]]>
          aatcgtgttt atcctcg 17
           <![CDATA[ <210> 243]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 243]]>
          ggaaacattg cggcaac 17
           <![CDATA[ <210> 244]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 244]]>
          cgtagtcttg ataccct 17
           <![CDATA[ <210> 245]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 245]]>
          tcgtagtctt gataccc 17
           <![CDATA[ <210> 246]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 246]]>
          gcttcaggtt cgtagtc 17
           <![CDATA[ <210> 247]]>
           <![CDATA[ <211> 17]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 247]]>
          taggcttcag gttcgta 17
           <![CDATA[ <210> 248]]>
           <![CDATA[ <211]]>> 25]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[probe
           <![CDATA[ <400> 248]]>
          tggcaacagt ggctgagaag accaa 25
           <![CDATA[ <210> 249]]>
           <![CDATA[ <211> 25]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                probe
           <![CDATA[ <400> 249]]>
          ccaagactga atggctggat ggcaa 25
           <![CDATA[ <210> 250]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 250]]>
          tccttggcct ttgaaagtcc 20
           <![CDATA[ <210> 251]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 251]]>
          ccaacatttg tcacttgctc 20
           <![CDATA[ <210> 252]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 252]]>
          cctttcatga atacatccat 20
           <![CDATA[ <210> 253]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 253]]>
          tcctttcatg aatacatcca 20
           <![CDATA[ <210> 254]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 254]]>
          gtcctttcat gaatacatcc 20
           <![CDATA[ <210> 255]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212]]>> DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 255]]>
          agtcctttca tgaatacatc 20
           <![CDATA[ <210> 256]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 256]]>
          aagtcctttc atgaatacat 20
           <![CDATA[ <210> 257]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 257]]>
          cttggccttt gaaagtcctt 20
           <![CDATA[ <210> 258]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 258]]>
          ccttggcctt tgaaagtcct 20
           <![CDATA[ <210> 259]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 259]]>
          ctccttggcc tttgaaagtc 20
           <![CDATA[ <210> 260]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 260]]>
          cctccttggc ctttgaaagt 20
           <![CDATA[ <210> 261]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <21]]>3> Artificial sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 261]]>
          ccctccttgg cctttgaaag 20
           <![CDATA[ <210> 262]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 262]]>
          tccctccttg gcctttgaaa 20
           <![CDATA[ <210> 263]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 263]]>
          ctccctcctt ggcctttgaa 20
           <![CDATA[ <210> 264]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 264]]>
          actccctccttggcctttga 20
           <![CDATA[ <210> 265]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 265]]>
          aactccctcc ttggcctttg 20
           <![CDATA[ <210> 266]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 266]]>
          caactccctc cttggccttt 20
           <![CDATA[ <210> 267]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 267]]>
          acaactccctccttggcctt 20
           <![CDATA[ <210> 268]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 268]]>
          cacaactccc tccttggcct 20
           <![CDATA[ <210> 269]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 269]]>
          ccacaactcc ctccttggcc 20
           <![CDATA[ <210> 270]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 270]]>
          gccacaactc cctccttggc 20
           <![CDATA[ <210> 271]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 271]]>
          agccacaact ccctcccttgg 20
           <![CDATA[ <210> 272]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 272]]>
          cagccacaac tccctccttg 20
           <![CDATA[ <210> 273]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 273]]>
          gcagccacaa ctccctcctt 20
           <![CDATA[ <210> 274]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 274]]>
          tcagcagcag ccacaactcc 20
           <![CDATA[ <210> 275]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 275]]>
          ctcagcagca gccacaactc 20
           <![CDATA[ <210> 276]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 276]]>
          tctcagcagc agccacaact 20
           <![CDATA[ <210> 277]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 277]]>
          ttctcagcag cagccacaac 20
           <![CDATA[ <210> 278]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 278]]>
          tttctcagca gcagccacaa 20
           <![CDATA[ <210> 279]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 279]]>
          ttttctcagc agcagccaca 20
           <![CDATA[ <210> 280]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 280]]>
          gttttctcag cagcagccac 20
           <![CDATA[ <210> 281]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 281]]>
          ggttttctca gcagcagcca 20
           <![CDATA[ <210> 282]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 282]]>
          tggttttctc agcagcagcc 20
           <![CDATA[ <210> 283]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 283]]>
          ttggttttct cagcagcagc 20
           <![CDATA[ <210> 284]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 284]]>
          tttggttttc tcagcagcag 20
           <![CDATA[ <210> 285]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 285]]>
          gtttggtttt ctcagcagca 20
           <![CDATA[ <210> 286]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 286]]>
          tgtttggttttctcagcagc 20
           <![CDATA[ <210>]]> 287
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 287]]>
          ctgtttggtt ttctcagcag 20
           <![CDATA[ <210> 288]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 288]]>
          cctgtttggt tttctcagca 20
           <![CDATA[ <210> 289]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 289]]>
          ccctgtttgg ttttctcagc 20
           <![CDATA[ <210> 290]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 290]]>
          accctgtttggttttctcag 20
           <![CDATA[ <210> 291]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 291]]>
          caccctgttt ggttttctca 20
           <![CDATA[ <210> 292]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 292]]>
          acaccctgtt tggttttctc 20
           <![CDATA[ <210> 293]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 293]]>
          cacaccctgt ttggttttct 20
           <![CDATA[ <210> 294]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 294]]>
          ccacaccctg tttggttttc 20
           <![CDATA[ <210> 295]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 295]]>
          gccacaccct gtttggtttt 20
           <![CDATA[ <210> 296]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 296]]>
          tgccacaccc tgtttggttt 20
           <![CDATA[ <210> 297]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 297]]>
          ctgccacacc ctgtttggtt 20
           <![CDATA[ <210> 298]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 298]]>
          tctgccacac cctgtttggt 20
           <![CDATA[ <210> 299]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 299]]>
          ttctgccaca ccctgtttgg 20
           <![CDATA[ <210> 300]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 300]]>
          cttctgccac accctgtttg 20
           <![CDATA[ <210> 301]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 301]]>
          gcttctgcca caccctgttt 20
           <![CDATA[ <210> 302]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 302]]>
          tgcttctgcc acaccctgtt 20
           <![CDATA[ <210> 303]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 303]]>
          ctgcttctgc cacaccctgt 20
           <![CDATA[ <210> 304]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 304]]>
          gctgcttctg ccacaccctg 20
           <![CDATA[ <210> 305]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> D]]>NA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 305]]>
          tgctgcttct gccacaccct 20
           <![CDATA[ <210> 306]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 306]]>
          ctgctgcttc tgccacaccc 20
           <![CDATA[ <210> 307]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 307]]>
          cctgctgctt ctgccacacc 20
           <![CDATA[ <210> 308]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 308]]>
          tcctgctgct tctgccacac 20
           <![CDATA[ <210> 309]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 309]]>
          ttcctgctgc ttctgccaca 20
           <![CDATA[ <210> 310]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 310]]>
          tttcctgctg cttctgccac 20
           <![CDATA[ <210> 311]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 311]]>
          ctttcctgct gcttctgcca 20
           <![CDATA[ <210> 312]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 312]]>
          tctttcctgc tgcttctgcc 20
           <![CDATA[ <210> 313]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 313]]>
          gtctttcctg ctgcttctgc 20
           <![CDATA[ <210> 314]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 314]]>
          tgtctttcct gctgcttctg 20
           <![CDATA[ <210> 315]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 315]]>
          ttgtctttcc tgctgcttct 20
           <![CDATA[ <210> 316]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 316]]>
          tttgtctttc ctgctgcttc 20
           <![CDATA[ <210> 317]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 317]]>
          ttttgtcttt cctgctgctt 20
           <![CDATA[ <210> 318]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 318]]>
          cttttgtctt tcctgctgct 20
           <![CDATA[ <210> 319]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 319]]>
          tcttttgtct ttcctgctgc 20
           <![CDATA[ <210> 320]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 320]]>
          ctcttttgtc tttcctgctg 20
           <![CDATA[ <210> 321]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 321]]>
          cctcttttgt ctttcctgct 20
           <![CDATA[ <210> 322]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 322]]>
          ccctcttttg tctttcctgc 20
           <![CDATA[ <210> 323]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 323]]>
          accctcttttgtctttcctg 20
           <![CDATA[ <210> 324]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 324]]>
          caccctcttttgtctttcct 20
           <![CDATA[ <210> 325]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 325]]>
          acaccctcttttgtctttcc 20
           <![CDATA[ <210> 326]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 326]]>
          aacaccctct tttgtctttc 20
           <![CDATA[ <210> 327]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 327]]>
          gaacaccctc ttttgtcttt 20
           <![CDATA[ <210> 328]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 328]]>
          agaacaccct cttttgtctt 20
           <![CDATA[ <210> 329]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 329]]>
          gagaacaccc tcttttgtct 20
           <![CDATA[ <210> 330]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 330]]>
          cctacataga gaacaccctc 20
           <![CDATA[ <210> 331]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223>]]> Description of Artificial Sequence: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 331]]>
          gcctacatatag agaacaccct 20
           <![CDATA[ <210> 332]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 332]]>
          agcctacata gagaacaccc 20
           <![CDATA[ <210> 333]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 333]]>
          gagcctacat agagaacacc 20
           <![CDATA[ <210> 334]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 334]]>
          ggagcctaca tagagaacac 20
           <![CDATA[ <210> 335]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 335]]>
          tggagcctac atagagaaca 20
           <![CDATA[ <210> 336]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 336]]>
          ttggagccta catagagaac 20
           <![CDATA[ <210> 337]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 337]]>
          tttggagcct acatagagaa 20
           <![CDATA[ <210> 338]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 338]]>
          ttttggagcc tacatagaga 20
           <![CDATA[ <210> 339]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 339]]>
          gttttggagc ctacatagag 20
           <![CDATA[ <210> 340]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> D]]>NA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 340]]>
          ggttttggag cctacataga 20
           <![CDATA[ <210> 341]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 341]]>
          tggttttgga gcctacatatag 20
           <![CDATA[ <210> 342]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 342]]>
          ttggttttgg agcctacata 20
           <![CDATA[ <210> 343]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 343]]>
          cttggttttg gagcctacat 20
           <![CDATA[ <210> 344]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 344]]>
          ccttggtttt ggagcctaca 20
           <![CDATA[ <210> 345]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 345]]>
          tccttggttt tggagcctac 20
           <![CDATA[ <210> 346]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 346]]>
          actccctccttggttttgga 20
           <![CDATA[ <210> 347]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 347]]>
          cactccctcc ttggttttgg 20
           <![CDATA[ <210> 348]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 348]]>
          ccactccctc cttggttttg 20
           <![CDATA[ <210> 349]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 349]]>
          tcagccactg ttgccacacc 20
           <![CDATA[ <210> 350]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 350]]>
          ctcagccact gttgccaacac 20
           <![CDATA[ <210> 351]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 351]]>
          tctcagccac tgttgccaca 20
           <![CDATA[ <210> 352]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 352]]>
          ttctcagcca ctgttgccac 20
           <![CDATA[ <210> 353]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 353]]>
          cttctcagcc actgttgcca 20
           <![CDATA[ <210> 354]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 354]]>
          tcttctcagc cactgttgcc 20
           <![CDATA[ <210> 355]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 355]]>
          gtcttctcag ccactgttgc 20
           <![CDATA[ <210> 356]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 356]]>
          ggtcttctca gccactgttg 20
           <![CDATA[ <210> 357]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400]]>> 357]]>
           <br/> <![CDATA[tggtcttctc agccactgtt 20
           <![CDATA[ <210> 358]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 358]]>
          ttggtcttct cagccactgt 20
           <![CDATA[ <210> 359]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 359]]>
          tttggtcttc tcagccactg 20
           <![CDATA[ <210> 360]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 360]]>
          cttgctcttt ggtcttctca 20
           <![CDATA[ <210> 361]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 361]]>
          acttgctctt tggtcttctc 20
           <![CDATA[ <210>]]> 362
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 362]]>
          tgtcacttgc tctttggtct 20
           <![CDATA[ <210> 363]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 363]]>
          ttgtcacttg ctctttggtc 20
           <![CDATA[ <210> 364]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 364]]>
          tttgtcactt gctctttggt 20
           <![CDATA[ <210> 365]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 365]]>
          atttgtcact tgctctttgg 20
           <![CDATA[ <210> 366]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 366]]>
          catttgtcac ttgctctttg 20
           <![CDATA[ <210> 367]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 367]]>
          acatttgtca cttgctcttt 20
           <![CDATA[ <210> 368]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 368]]>
          aacatttgtc acttgctctt 20
           <![CDATA[ <210> 369]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 369]]>
          caacatttgt cacttgctct 20
           <![CDATA[ <210> 370]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 370]]>
          tccaacattt gtcacttgct 20
           <![CDATA[ <210> 371]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 371]]>
          ctccaacatt tgtcacttgc 20
           <![CDATA[ <210> 372]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 372]]>
          ctcctccaac atttgtcact 20
           <![CDATA[ <210> 373]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 373]]>
          gctcctccaa catttgtcac 20
           <![CDATA[ <210> 374]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400>]]> 374
          gctgtcacac ccgtcaccac 20
           <![CDATA[ <210> 375]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> ]]>DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 375]]>
          tgctgtcacca cccgtcacca 20
           <![CDATA[ <210> 376]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 376]]>
          ctgctgtcac acccgtcacc 20
           <![CDATA[ <210> 377]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 377]]>
          actgctgtca cacccgtcac 20
           <![CDATA[ <210> 378]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 378]]>
          tactgctgtc acacccgtca 20
           <![CDATA[ <210> 379]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 379]]>
          ctactgctgt cacacccgtc 20
           <![CDATA[ <210> 380]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 380]]>
          gctactgctg tcacacccgt 20
           <![CDATA[ <210> 381]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 381]]>
          ggctactgct gtcacacccg 20
           <![CDATA[ <210> 382]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 382]]>
          gggctactgc tgtcacaccc 20
           <![CDATA[ <210> 383]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 383]]>
          tgggctactg ctgtcacacc 20
           <![CDATA[ <210> 384]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 384]]>
          ctgggctact gctgtcacac 20
           <![CDATA[ <210> 385]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 385]]>
          tctgggctac tgctgtcaca 20
           <![CDATA[ <210> 386]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 386]]>
          ttctgggcta ctgctgtcac 20
           <![CDATA[ <210> 387]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 387]]>
          cttctgggct actgctgtca 20
           <![CDATA[ <210> 388]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 388]]>
          tcttctgggc tactgctgtc 20
           <![CDATA[ <210> 389]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 389]]>
          gtcttctggg ctactgctgt 20
           <![CDATA[ <210> 390]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 390]]>
          tgtcttctgg gctactgctg 20
           <![CDATA[ <210> 391]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 391]]>
          ctgtcttctg ggctactgct 20
           <![CDATA[ <210> 392]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 392]]>
          actgtcttct gggctactgc 20
           <![CDATA[ <210> 393]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 393]]>
          cactgtcttc tgggctactg 20
           <![CDATA[ <210> 394]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 394]]>
          ccactgtctt ctggggctact 20
           <![CDATA[ <210> 395]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 395]]>
          tccactgtct tctgggctac 20
           <![CDATA[ <210> 396]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 396]]>
          ctccactgtc ttctgggcta 20
           <![CDATA[ <210> 397]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 397]]>
          cctccactgt cttctgggct 20
           <![CDATA[ <210> 398]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 398]]>
          ccctccactg tcttctgggc 20
           <![CDATA[ <210> 399]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 399]]>
          tccctccact gtcttctggg 20
           <![CDATA[ <210> 400]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 400]]>
          ctccctccac tgtcttctgg 20
           <![CDATA[ <210> 401]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 401]]>
          gctccctcca ctgtcttctg 20
           <![CDATA[ <210> 402]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 402]]>
          tgctccctcc actgtcttct 20
           <![CDATA[ <210> 403]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 403]]>
          ctgctccctc cactgtcttc 20
           <![CDATA[ <210> 404]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 404]]>
          ccctgctccc tccactgtct 20
           <![CDATA[ <210> 405]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 405]]>
          tccctgctcc ctccactgtc 20
           <![CDATA[ <210> 406]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 406]]>
          ctccctgctc cctccactgt 20
           <![CDATA[ <210> 407]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 407]]>
          gctccctgct ccctccactg 20
           <![CDATA[ <210> 408]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 408]]>
          tgctccctgc tccctccact 20
           <![CDATA[ <210> 409]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 409]]>
          atgctccctg ctccctccac 20
           <![CDATA[ <210> 410]]>
           <![CDATA[ <211>]]> 20
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 410]]>
          aatgctccct gctccctcca 20
           <![CDATA[ <210> 411]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 411]]>
          caatgctccc tgctccctcc 20
           <![CDATA[ <210> 412]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 412]]>
          gcaatgctcc ctgctccctc 20
           <![CDATA[ <210> 413]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 413]]>
          tgcaatgctc cctgctccct 20
           <![CDATA[ <210> 414]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 414]]>
          ctgcaatgct ccctgctccc 20
           <![CDATA[ <210> 415]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 415]]>
          gctgcaatgc tccctgctcc 20
           <![CDATA[ <210> 416]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 416]]>
          tgctgcaatg ctccctgctc 20
           <![CDATA[ <210> 417]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 417]]>
          ctgctgcaat gctccctgct 20
           <![CDATA[ <210> 418]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 418]]>
          gctgctgcaa tgctccctgc 20
           <![CDATA[ <210> 419]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 419]]>
          ggctgctgca atgctccctg 20
           <![CDATA[ <210> 420]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 420]]>
          tggctgctgc aatgctccct 20
           <![CDATA[ <210> 421]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 421]]>
          gtggctgctg caatgctccc 20
           <![CDATA[ <210> 422]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 422]]>
          agtggctgct gcaatgctcc 20
           <![CDATA[ <210> 423]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 423]]>
          cagtggctgc tgcaatgctc 20
           <![CDATA[ <210> 424]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 424]]>
          ccagtggctg ctgcaatgct 20
           <![CDATA[ <210> 425]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 425]]>
          gccagtggct gctgcaatgc 20
           <![CDATA[ <210> 426]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 426]]>
          gcccaactgg tcctttttga 20
           <![CDATA[ <210> 427]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 427]]>
          tgcccaactg gtcctttttg 20
           <![CDATA[ <210> 428]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 428]]>
          ttgcccaact ggtccttttt 20
           <![CDATA[ <210> 429]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 429]]>
          cttgcccaac tggtcctttt 20
           <![CDATA[ <210> 430]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 430]]>
          tcttgcccaa ctggtccttt 20
           <![CDATA[ <210> 431]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 431]]>
          ttcttgccca actggtcctt 20
           <![CDATA[ <210> 432]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 432]]>
          attcttgccc aactggtcct 20
           <![CDATA[ <210> 433]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 433]]>
          cattcttgcc caactggtcc 20
           <![CDATA[ <210> 434]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 434]]>
          tcattcttgc ccaactggtc 20
           <![CDATA[ <210> 435]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 435]]>
          ttcattcttg cccaactggt 20
           <![CDATA[ <210> 436]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 436]]>
          cttcattctt gcccaactgg 20
           <![CDATA[ <210> 437]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 437]]>
          tcttcattcttgcccaactg 20
           <![CDATA[ <210> 438]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 438]]>
          ttcttcattc ttgcccaact 20
           <![CDATA[ <210> 439]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 439]]>
          cttcttcatt cttgcccaac 20
           <![CDATA[ <210> 440]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 440]]>
          ccttcttcat tcttgcccaa 20
           <![CDATA[ <210>]]> 441
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 441]]>
          tccttcttca ttcttgccca 20
           <![CDATA[ <210> 442]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 442]]>
          ctccttcttc attcttgccc 20
           <![CDATA[ <210> 443]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 443]]>
          gctccttctt cattcttgcc 20
           <![CDATA[ <210> 444]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 444]]>
          ggctccttct tcattcttgc 20
           <![CDATA[ <210> 445]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 445]]>
          gggctccttc ttcattcttg 20
           <![CDATA[ <210> 446]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 446]]>
          ggggctcctt cttcattctt 20
           <![CDATA[ <210> 447]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 447]]>
          tggggctcct tcttcattct 20
           <![CDATA[ <210> 448]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 448]]>
          gtggggctcc ttcttcattc 20
           <![CDATA[ <210> 449]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 449]]>
          tgtggggctc cttcttcatt 20
           <![CDATA[ <210> 450]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 450]]>
          ctgtggggct ccttcttcat 20
           <![CDATA[ <210> 451]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 451]]>
          cctgtggggc tccttcttca 20
           <![CDATA[ <210> 452]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 452]]>
          tcctgtgggg ctccttcttc 20
           <![CDATA[ <210> 453]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 453]]>
          ttcctgtggg gctccttctt 20
           <![CDATA[ <210> 454]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 454]]>
          cttcctgtgg ggctccttct 20
           <![CDATA[ <210> 455]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 455]]>
          ccttcctgtg gggctccttc 20
           <![CDATA[ <210> 456]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 456]]>
          tccttcctgt ggggctcctt 20
           <![CDATA[ <210> 457]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 457]]>
          ttccttcctg tggggctcct 20
           <![CDATA[ <210> 458]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 458]]>
          attccttcct gtggggctcc 20
           <![CDATA[ <210> 459]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 459]]>
          aattccttcc tgtggggctc 20
           <![CDATA[ <210> 460]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 460]]>
          gaattccttc ctgtggggct 20
           <![CDATA[ <210> 461]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 461]]>
          agaattcctt cctgtggggc 20
           <![CDATA[ <210> 462]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 462]]>
          aggatccaca ggcatatctt 20
           <![CDATA[ <210> 463]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 463]]>
          caggatccac aggcatatct 20
           <![CDATA[ <210> 464]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 464]]>
          tcaggatcca caggcatac 20
           <![CDATA[ <210> 465]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 465]]>
          gtcaggatcc acaggcatat 20
           <![CDATA[ <210> 466]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> ]]>Artificial sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 466]]>
          tgtcaggatc cacaggcata 20
           <![CDATA[ <210> 467]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 467]]>
          ttgtcaggat ccacaggcat 20
           <![CDATA[ <210> 468]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 468]]>
          agcctcattg tcaggatcca 20
           <![CDATA[ <210> 469]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 469]]>
          aagcctcatt gtcaggatcc 20
           <![CDATA[ <210> 470]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 470]]>
          taagcctcat tgtcaggatc 20
           <![CDATA[ <210> 471]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 471]]>
          ataagcctca ttgtcaggat 20
           <![CDATA[ <210> 472]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 472]]>
          cataagcctc attgtcagga 20
           <![CDATA[ <210> 473]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 473]]>
          gcatttcata agcctcattg 20
           <![CDATA[ <210> 474]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 474]]>
          ggcatttcat aagcctcatt 20
           <![CDATA[ <210> 475]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 475]]>
          cagaaggcat ttcataagcc 20
           <![CDATA[ <210> 476]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 476]]>
          tcagaaggca tttcataagc 20
           <![CDATA[ <210> 477]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 477]]>
          ctcagaaggc atttcataag 20
           <![CDATA[ <210> 478]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 478]]>
          cctcagaagg catttcataa 20
           <![CDATA[ <210> 479]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 479]]>
          tcctcagaag gcatttcata 20
           <![CDATA[ <210> 480]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> D]]>NA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 480]]>
          ttcctcagaa ggcatttcat 20
           <![CDATA[ <210> 481]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 481]]>
          cttgataccc ttccctcagaa 20
           <![CDATA[ <210> 482]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>]]> DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 482]]>
          tcttgatacc cttccctcaga 20
           <![CDATA[ <210> 483]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 483]]>
          gtcttgatac ccttccctcag 20
           <![CDATA[ <210> 484]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 484]]>
          agtcttgata cccttcctca 20
           <![CDATA[ <210> 485]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 485]]>
          tagtcttgat acccttcctc 20
           <![CDATA[ <210> 486]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 486]]>
          gtagtcttga tacccttcct 20
           <![CDATA[ <210> 487]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 487]]>
          tcgtagtctt gatacccttc 20
           <![CDATA[ <210> 488]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 488]]>
          ttcgtagtct tgataccctt 20
           <![CDATA[ <210> 489]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 489]]>
          tcaggttcgt agtcttgata 20
           <![CDATA[ <210> 490]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 490]]>
          cttcaggttc gtagtcttga 20
           <![CDATA[ <210> 491]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 491]]>
          gcttcaggtt cgtagtcttg 20
           <![CDATA[ <210> 492]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 492]]>
          ggcttcaggt tcgtagtctt 20
           <![CDATA[ <210> 493]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 493]]>
          aggcttcagg ttcgtaggtct 20
           <![CDATA[ <210> 494]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 494]]>
          taggcttcag gttcgtagtc 20
           <![CDATA[ <210> 495]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 495]]>
          ttaggcttca ggttcgtagt 20
           <![CDATA[ <210> 496]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 496]]>
          taccctctgac tcagtccacc 20
           <![CDATA[ <210> 497]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 497]]>
          atacctctga ctcagtccac 20
           <![CDATA[ <210> 498]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 498]]>
          acaggggcat atcaaagtca 20
           <![CDATA[ <210> 499]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 499]]>
          ccctcaagca cttttctctg 20
           <![CDATA[ <210> 500]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 500]]>
          cagccctcaa gcacttttct 20
           <![CDATA[ <210> 501]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 501]]>
          tcagctaggc aactcaatgt 20
           <![CDATA[ <210> 502]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 502]]>
          tgtttcagct aggcaactca 20
           <![CDATA[ <210> 503]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 503]]>
          acaagacaat tccagcccac 20
           <![CDATA[ <210> 504]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 504]]>
          tggtttgtgtgattagtgca 20
           <![CDATA[ <210> 505]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 505]]>
          gggaagtgat gctcagagat 20
           <![CDATA[ <210> 506]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Artificial Sequence of]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 506]]>
          gagtggagaa gaaggtcaga 20
           <![CDATA[ <210> 507]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 507]]>
          aaaagagcac agagtggaga 20
           <![CDATA[ <210> 508]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 508]]>
          cccaacctca aaagagcaca 20
           <![CDATA[ <210> 509]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 509]]>
          tcccaacctc aaaagagcac 20
           <![CDATA[ <210> 510]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 510]]>
          ttcccaacct caaaagagca 20
           <![CDATA[ <210> 511]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213>]]> Artificial Sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 511]]>
          cttcccaacc tcaaaagagc 20
           <![CDATA[ <210> 512]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 512]]>
          cttgtcttcc caacctcaaa 20
           <![CDATA[ <210> 513]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 513]]>
          atcttgtctt cccaacctca 20
           <![CDATA[ <210>]]> 514
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 514]]>
          cccttgccac aaaaacaaca 20
           <![CDATA[ <210> 515]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 515]]>
          gcccttgcca caaaaacaac 20
           <![CDATA[ <210> 516]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 516]]>
          tgcccttgcc acaaaaacaa 20
           <![CDATA[ <210> 517]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 517]]>
          gctgcccttg ccacaaaaac 20
           <![CDATA[ <210> 518]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 518]]>
          tggattttag ctgcccttgc 20
           <![CDATA[ <210> 519]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 519]]>
          tgcttggaat cccagtgctt 20
           <![CDATA[ <210>]]> 520
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 520]]>
          ttgcttggaa tcccagtgct 20
           <![CDATA[ <210> 521]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 521]]>
          cttgcttgga atcccagtgc 20
           <![CDATA[ <210> 522]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 522]]>
          agaggctgac aagggtaaga 20
           <![CDATA[ <210> 523]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 523]]>
          gggcattgct gtctgtatga 20
           <![CDATA[ <210> 524]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 524]]>
          gcagtgacaa catcctcagg 20
           <![CDATA[ <210> 525]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 525]]>
          cagcagtgac aacatcctca 20
           <![CDATA[ <210> 526]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 526]]>
          aattgcagca gtgacaacat 20
           <![CDATA[ <210> 527]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 527]]>
          tgaattgcag cagtgacaac 20
           <![CDATA[ <210> 528]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 528]]>
          ctgggacacc ttcactcttt 20
           <![CDATA[ <210> 529]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 529]]>
          ccctttgttc ccacatcaca 20
           <![CDATA[ <210> 530]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 530]]>
          cccctttgtt cccacatcac 20
           <![CDATA[ <210> 531]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 531]]>
          tcccctttgt tcccacatca 20
           <![CDATA[ <210> 532]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 532]]>
          atcccctttg ttcccacatc 20
           <![CDATA[ <210> 533]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 533]]>
          tatccccttt gttcccacat 20
           <![CDATA[ <210> 534]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 534]]>
          ttatcccctt tgttcccaca 20
           <![CDATA[ <210> 535]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 535]]>
          agcttacctg ttgccacacc 20
           <![CDATA[ <210> 536]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 536]]>
          gagcttacct gttgccacac 20
           <![CDATA[ <210> 537]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 537]]>
          ggagcttacc tgttgccaca 20
           <![CDATA[ <210> 538]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 538]]>
          tggagcttac ctgttgccac 20
           <![CDATA[ <210> 539]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 539]]>
          tgggccacac taatcactag 20
           <![CDATA[ <210> 540]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 540]]>
          actgggccac actaatcact 20
           <![CDATA[ <210> 541]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 541]]>
          atactgggccacactaatca 20
           <![CDATA[ <210> 542]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 542]]>
          tttctggcac tctcatcctc 20
           <![CDATA[ <210> 543]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 543]]>
          cagagcccat taaaggtgca 20
           <![CDATA[ <210> 544]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 544]]>
          acagagccca ttaaaggtgc 20
           <![CDATA[ <210> 545]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 545]]>
          aacagagccc attaaaggtg 20
           <![CDATA[ <210> 546]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 546]]>
          caacagagcc cattaaaggt 20
           <![CDATA[ <210> 547]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 547]]>
          gcaacagagc ccattaaagg 20
           <![CDATA[ <210> 548]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 548]]>
          tgcaacagag cccattaaag 20
           <![CDATA[ <210> 549]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 549]]>
          ttgcaacaga gcccattaaa 20
           <![CDATA[ <210> 550]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 550]]>
          attgcaacag agcccattaa 20
           <![CDATA[ <210> 551]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 551]]>
          gattgcaaca gagcccatta 20
           <![CDATA[ <210> 552]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 552]]>
          ggattgcaac agagcccatt 20
           <![CDATA[ <210> 553]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 553]]>
          tggattgcaa cagagcccat 20
           <![CDATA[ <210> 554]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 554]]>
          ttggattgca acagagccca 20
           <![CDATA[ <210> 555]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 555]]>
          ctcatgggtt cttcctcaac 20
           <![CDATA[ <210> 556]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 556]]>
          acctcatggg ttcttcctca 20
           <![CDATA[ <210> 557]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 557]]>
          ttcactactg ccagggtggt 20
           <![CDATA[ <210> 558]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 558]]>
          actccccaga taagcctcag 20
           <![CDATA[ <210> 559]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 559]]>
          tggggacact catctaagga 20
           <![CDATA[ <210> 560]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 560]]>
          gagagtggag gatggggaca 20
           <![CDATA[ <210> 561]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 561]]>
          gaacagtgga ggagagtgga 20
           <![CDATA[ <210> 562]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 562]]>
          gagaacagtg gaggagagtg 20
           <![CDATA[ <210> 563]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 563]]>
          tctcagccac tggtacaaat 20
           <![CDATA[ <210> 564]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 564]]>
          ttctcagcca ctggtacaaa 20
           <![CDATA[ <210> 565]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 565]]>
          caaggggagg gtcaggtagc 20
           <![CDATA[ <210> 566]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 566]]>
          acaagggggagggtcaggtag 20
           <![CDATA[ <210> 567]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 567]]>
          cacaagggga gggtcaggta 20
           <![CDATA[ <210> 568]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 568]]>
          gtcagggcaa gggtatgctt 20
           <![CDATA[ <210> 569]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 569]]>
          tgtcagggca agggtatgct 20
           <![CDATA[ <210> 570]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 570]]>
          cactctcatg gtgcctacat 20
           <![CDATA[ <210> 571]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 571]]>
          ttcactctca tggtgcctac 20
           <![CDATA[ <210> 572]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 572]]>
          tttcactctc atggtgccta 20
           <![CDATA[ <210> 573]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 573]]>
          atttcactct catggtgcct 20
           <![CDATA[ <210> 574]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 574]]>
          ggaaactctc ccagacactt 20
           <![CDATA[ <210> 575]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 575]]>
          tggaaactct cccagacact 20
           <![CDATA[ <210> 576]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223>]]> Description of Artificial Sequence: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 576]]>
          tcttggacta cccacttcct 20
           <![CDATA[ <210> 577]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 577]]>
          ggggaagtga tatagtggct 20
           <![CDATA[ <210> 578]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 578]]>
          tggggaagtg atatagtggc 20
           <![CDATA[ <210> 579]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 579]]>
          agacccaaag gaaggtaagt 20
           <![CDATA[ <210> 580]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 580]]>
          gtacatgttt ccctgttgct 20
           <![CDATA[ <210> 581]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 581]]>
          aggtggtgta tgagcagaga 20
           <![CDATA[ <210> 582]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 582]]>
          caggtggtgt atgagcagag 20
           <![CDATA[ <210> 583]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 583]]>
          gtcaggtggt gtatgagcag 20
           <![CDATA[ <210> 584]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 584]]>
          agtcaggtgg tgtatgagca 20
           <![CDATA[ <210> 585]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> D]]>NA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 585]]>
          cagtcaggtg gtgtatgagc 20
           <![CDATA[ <210> 586]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 586]]>
          ccagtcaggtggtgtatgag 20
           <![CDATA[ <210> 587]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 587]]>
          tgggatagac caagtgttct 20
           <![CDATA[ <210> 588]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 588]]>
          gcaagacact gttgaggagc 20
           <![CDATA[ <210> 589]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 589]]>
          acaactggct agctatcctt 20
           <![CDATA[ <210> 590]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 590]]>
          cacaactggc tagctatcct 20
           <![CDATA[ <210> 591]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 591]]>
          acacaactgg ctagctatcc 20
           <![CDATA[ <210> 592]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 592]]>
          cacacaactg gctagctatc 20
           <![CDATA[ <210> 593]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 593]]>
          cagagggtcc ataacactca 20
           <![CDATA[ <210> 594]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 594]]>
          tcagagggtc cataacactc 20
           <![CDATA[ <210> 595]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 595]]>
          tgtgacctgt gcttgtttgt 20
           <![CDATA[ <210> 596]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 596]]>
          ttgcctgtga cctgtgcttg 20
           <![CDATA[ <210> 597]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 597]]>
          gtcaagcaca aggacaagaa 20
           <![CDATA[ <210> 598]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 598]]>
          agtcaagcac aaggacaaga 20
           <![CDATA[ <210> 599]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 599]]>
          aagtcaagca caaggacaag 20
           <![CDATA[ <210> 600]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 600]]>
          gaagtcaagc acaaggacaa 20
           <![CDATA[ <210> 601]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400>]]> 601
          tgaagtcaag cacaaggaca 20
           <![CDATA[ <210> 602]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 602]]>
          tctgaagtca agcacaagga 20
           <![CDATA[ <210> 603]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 603]]>
          atgcagttct atcccactca 20
           <![CDATA[ <210> 604]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 604]]>
          aaggaacaag ggaagtgcac 20
           <![CDATA[ <210> 605]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 605]]>
          gaaggaacaa gggaagtgca 20
           <![CDATA[ <210> 606]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 606]]>
          tgaaggaaca agggaagtgc 20
           <![CDATA[ <210> 607]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 607]]>
          tctggctcag tattctttgc 20
           <![CDATA[ <210> 608]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 608]]>
          cccacatcta agcaggaaga 20
           <![CDATA[ <210> 609]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 609]]>
          ccatcatgct ggatcaaaca 20
           <![CDATA[ <210> 610]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 610]]>
          gccatcatgc tggatcaaac 20
           <![CDATA[ <210> 611]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 611]]>
          ctggccatca tgctggatca 20
           <![CDATA[ <210>]]> 612
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 612]]>
          tcacactcca accctgggca 20
           <![CDATA[ <210> 613]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 613]]>
          ttcacactcc aaccctgggc 20
           <![CDATA[ <210> 614]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 614]]>
          cattcacact ccaaccctgg 20
           <![CDATA[ <210> 615]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 615]]>
          tcattcacac tccaaccctg 20
           <![CDATA[ <210> 616]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 616]]>
          tgcagataaa ccatcccact 20
           <![CDATA[ <210> 617]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 617]]>
          aggcagttgt ggtaggggtt 20
           <![CDATA[ <210> 618]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 618]]>
          ggtgttgtct gaaagcagga 20
           <![CDATA[ <210> 619]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 619]]>
          tggtgttgtc tgaaagcagg 20
           <![CDATA[ <210> 620]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 620]]>
          ttggtgttgt ctgaaagcag 20
           <![CDATA[ <210> 621]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 621]]>
          gggagaaggg attttcaagg 20
           <![CDATA[ <210> 622]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 622]]>
          tagcatcctt ccacaccatt 20
           <![CDATA[ <210> 623]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 623]]>
          caatagcatc cttccacacc 20
           <![CDATA[ <210> 624]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 624]]>
          aaatgcaaaa tgggcttcac 20
           <![CDATA[ <210> 625]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 625]]>
          tgcttgttgc catgctgggg 20
           <![CDATA[ <210> 626]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 626]]>
          tgtgcttgtt gccatgctgg 20
           <![CDATA[ <210> 627]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 627]]>
          ttgtgcttgttgccatgctg 20
           <![CDATA[ <210> 628]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 628]]>
          tttgtgcttg ttgccatgct 20
           <![CDATA[ <210> 629]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 629]]>
          ttttgtgcttgttgccatgc 20
           <![CDATA[ <210> 630]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 630]]>
          attttgtgct tgttgccatg 20
           <![CDATA[ <210> 631]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 631]]>
          atggatgggt ggacaaatgg 20
           <![CDATA[ <210> 632]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 632]]>
          tggatcagat ggatgggtgg 20
           <![CDATA[ <210> 633]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 633]]>
          atggatcaga tggatgggtg 20
           <![CDATA[ <210> 634]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 634]]>
          aatggatcag atggatgggt 20
           <![CDATA[ <210> 635]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 635]]>
          cttgggctgg acttttttgc 20
           <![CDATA[ <210> 636]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 636]]>
          gtcactggat ggttgggagc 20
           <![CDATA[ <210> 637]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 637]]>
          ggtcactgga tggttgggag 20
           <![CDATA[ <210> 638]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 638]]>
          aggtcactgg atggttggga 20
           <![CDATA[ <210> 639]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 639]]>
          gaggtcactg gatggttggg 20
           <![CDATA[ <210> 640]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 640]]>
          agaggtcact ggatggttgg 20
           <![CDATA[ <210> 641]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 641]]>
          taagaggtca ctggatggtt 20
           <![CDATA[ <210> 642]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 642]]>
          gcaatggaac actgctacat 20
           <![CDATA[ <210> 643]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 643]]>
          tgcaatggaa cactgctaca 20
           <![CDATA[ <210> 644]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 644]]>
          ttgcaatgga acactgctac 20
           <![CDATA[ <210> 645]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 645]]>
          cttgcaatgg aacactgcta 20
           <![CDATA[ <210> 646]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 646]]>
          tcttgcaatg gaacactgct 20
           <![CDATA[ <210> 647]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 647]]>
          ttcttgcaat ggaacactgc 20
           <![CDATA[ <210> 648]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 648]]>
          cttcttgcaa tggaacactg 20
           <![CDATA[ <210> 649]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 649]]>
          cctcaagcca tctagctcaa 20
           <![CDATA[ <210> 650]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 650]]>
          ccctcaagcc atctagctca 20
           <![CDATA[ <210> 651]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 651]]>
          accctcaagc catctagctc 20
           <![CDATA[ <210> 652]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 652]]>
          gaccctcaag ccatctagct 20
           <![CDATA[ <210> 653]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 653]]>
          tgaccctcaa gccatctagc 20
           <![CDATA[ <210> 654]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 654]]>
          atgaccctca agccatctag 20
           <![CDATA[ <210> 655]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> ]]>Artificial sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 655]]>
          ctatgaccct caagccatct 20
           <![CDATA[ <210> 656]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 656]]>
          caccttcaaa cccctttcaa 20
           <![CDATA[ <210> 657]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 657]]>
          tcaccttcaa acccctttca 20
           <![CDATA[ <210> 658]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 658]]>
          agggatcacc ttcaaaccccc 20
           <![CDATA[ <210> 659]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400>]]> 659
          tgttttgctg ctcgaatcat 20
           <![CDATA[ <210> 660]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 660]]>
          tgaagaacga agcaagttgt 20
           <![CDATA[ <210> 661]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 661]]>
          ctgaagaacg aagcaagttg 20
           <![CDATA[ <210> 662]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 662]]>
          aactgaagaa cgaagcaagt 20
           <![CDATA[ <210> 663]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 663]]>
          acaactaacc acggcacaat 20
           <![CDATA[ <210> 664]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 664]]>
          tacaactaac cacggcacaa 20
           <![CDATA[ <210> 665]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 665]]>
          gagttttacc caagtggcac 20
           <![CDATA[ <210> 666]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 666]]>
          ggaggaaagt aaggtcaggt 20
           <![CDATA[ <210> 667]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 667]]>
          ggggaggaaag taaggtcagg 20
           <![CDATA[ <210> 668]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223>]]> Description of Artificial Sequence: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 668]]>
          aggggaggaaa gtaaggtcag 20
           <![CDATA[ <210> 669]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 669]]>
          gagggaggaa agtaaggtca 20
           <![CDATA[ <210> 670]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 670]]>
          gggagggagga aagtaaggtc 20
           <![CDATA[ <210> 671]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 671]]>
          gagtattgtg tgtgcccttt 20
           <![CDATA[ <210> 672]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 672]]>
          tgagtattgtgtgtgccctt 20
           <![CDATA[ <210> 673]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 673]]>
          gggaagagga aaagcttgga 20
           <![CDATA[ <210> 674]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 674]]>
          agcagagatt atggcagaga 20
           <![CDATA[ <210> 675]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 675]]>
          cacaagtagg cagcacaggt 20
           <![CDATA[ <210> 676]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 676]]>
          gcacaagtag gcagcacagg 20
           <![CDATA[ <210> 677]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 677]]>
          tgcacaagta ggcagcacag 20
           <![CDATA[ <210> 678]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 678]]>
          agcaaggaaa cctacagccca 20
           <![CDATA[ <210> 679]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 679]]>
          gcaatgggat ccaccacagc 20
           <![CDATA[ <210> 680]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 680]]>
          agcaatggga tccaccacag 20
           <![CDATA[ <210> 681]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 681]]>
          cagcaatggg atccaccaca 20
           <![CDATA[ <210> 682]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213>]]> Artificial Sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 682]]>
          gcagcaatgg gatccaccac 20
           <![CDATA[ <210> 683]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 683]]>
          aagttttgga gtggaggagt 20
           <![CDATA[ <210> 684]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 684]]>
          ggaaaatatg ggggcaacag 20
           <![CDATA[ <210> 685]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 685]]>
          gggaaaatat gggggcaaca 20
           <![CDATA[ <210> 686]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400]]>> 686]]>
           <br/> <![CDATA[ggggaaaata tgggggcaac 20
           <![CDATA[ <210> 687]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 687]]>
          aggggaaaat atgggggcaa 20
           <![CDATA[ <210> 688]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 688]]>
          gaggggaaaa tatgggggca 20
           <![CDATA[ <210> 689]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 689]]>
          caccaaccaa ccagaggggga 20
           <![CDATA[ <210> 690]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 690]]>
          gcaccaacca accagagggg 20
           <![CDATA[ <210> 691]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 691]]>
          agcaccaacc aaccagaggg 20
           <![CDATA[ <210> 692]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 692]]>
          gagcaccaac caaccagagg 20
           <![CDATA[ <210> 693]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> ]]>Artificial sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 693]]>
          caaaagagaa gcaacccact 20
           <![CDATA[ <210> 694]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 694]]>
          gggtctcact agcctaaagt 20
           <![CDATA[ <210> 695]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 695]]>
          ggggtctcac tagcctaaag 20
           <![CDATA[ <210> 696]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 696]]>
          agtgtgagag gagcaagctg 20
           <![CDATA[ <210> 697]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 697]]>
          gagtctccat gagcaatgct 20
           <![CDATA[ <210> 698]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 698]]>
          cattcccaag agaccccagat 20
           <![CDATA[ <210> 699]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 699]]>
          ccattcccaa gagacccaga 20
           <![CDATA[ <210> 700]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 700]]>
          accacctgag aacactgaat 20
           <![CDATA[ <210> 701]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 701]]>
          gaccacctga gaacactgaa 20
           <![CDATA[ <210> 702]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 702]]>
          agaccacctg agaacactga 20
           <![CDATA[ <210> 703]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 703]]>
          gagaccacct gagaacactg 20
           <![CDATA[ <210> 704]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 704]]>
          agagaccacc tgagaacact 20
           <![CDATA[ <210> 705]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 705]]>
          tagagaccac ctgagaacac 20
           <![CDATA[ <210> 706]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 706]]>
          cctagagacca cctgagaaca 20
           <![CDATA[ <210> 707]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 707]]>
          tgcccaactt acaattctcc 20
           <![CDATA[ <210> 708]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 708]]>
          actgccattg acctctgctt 20
           <![CDATA[ <210> 709]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>]]> DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 709]]>
          cactgccatt gacctctgct 20
           <![CDATA[ <210> 710]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 710]]>
          acactgccat tgacctctgc 20
           <![CDATA[ <210> 711]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 711]]>
          ccacttcacc cagaattcct 20
           <![CDATA[ <210> 712]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 712]]>
          aaacacactt cagaccacac 20
           <![CDATA[ <210> 713]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 713]]>
          agccgacata catctccaaa 20
           <![CDATA[ <210> 714]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 714]]>
          gtcaatcaac tgcatccaga 20
           <![CDATA[ <210> 715]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 715]]>
          ctgtcaatca actgcatcca 20
           <![CDATA[ <210> 716]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 716]]>
          ggcactagga gaccctggga 20
           <![CDATA[ <210> 717]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 717]]>
          catgcataag cagcctgagt 20
           <![CDATA[ <210> 718]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 718]]>
          gtcatcatgc ataagcagcc 20
           <![CDATA[ <210> 719]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 719]]>
          aacccttctg tcatcatgca 20
           <![CDATA[ <210> 720]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 720]]>
          tgggaaccct tctgtcatca 20
           <![CDATA[ <210>]]> 721
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 721]]>
          aggcagggct agacaaaatg 20
           <![CDATA[ <210> 722]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 722]]>
          gaggcagggc tagacaaaat 20
           <![CDATA[ <210> 723]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 723]]>
          agaggcaggg ctagacaaaa 20
           <![CDATA[ <210> 724]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 724]]>
          cagaggcagg gctagacaaa 20
           <![CDATA[ <210> 725]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 725]]>
          ggcaatcaag ccaaacaaat 20
           <![CDATA[ <210> 726]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 726]]>
          accctgctag ccagaagaga 20
           <![CDATA[ <210> 727]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 727]]>
          aaccctgcta gccagaagag 20
           <![CDATA[ <210> 728]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 728]]>
          aaaccctgct agccagaaga 20
           <![CDATA[ <210> 729]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 729]]>
          agacctagtt cccctgcccc 20
           <![CDATA[ <210> 730]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 730]]>
          gagacctagt tcccctgccc 20
           <![CDATA[ <210> 731]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 731]]>
          ctgagagggg tgcttttaag 20
           <![CDATA[ <210> 732]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 732]]>
          ttcctgagag gggtgctttt 20
           <![CDATA[ <210> 733]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 733]]>
          tttcctgagaggggtgcttt 20
           <![CDATA[ <210> 734]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 734]]>
          ccatgaagct taaccctctc 20
           <![CDATA[ <210> 735]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 735]]>
          cccatgaagc ttaaccctct 20
           <![CDATA[ <210> 736]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 736]]>
          tcccatgaag cttaaccctc 20
           <![CDATA[ <210> 737]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 737]]>
          ttcccatgaa gcttaaccct 20
           <![CDATA[ <210> 738]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 738]]>
          accctgctga tttcccatga 20
           <![CDATA[ <210> 739]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 739]]>
          ctaccctgct gatttcccat 20
           <![CDATA[ <210> 740]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 740]]>
          actaccctgc tgatttccca 20
           <![CDATA[ <210>]]> 741
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 741]]>
          aactaccctg ctgatttccc 20
           <![CDATA[ <210> 742]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 742]]>
          ccttttgacc ctctgtttgc 20
           <![CDATA[ <210> 743]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 743]]>
          gcacaatgct tgagaaggtg 20
           <![CDATA[ <210> 744]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 744]]>
          caatggggaga caggagctaa 20
           <![CDATA[ <210> 745]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 745]]>
          acaatggggag acaggagcta 20
           <![CDATA[ <210> 746]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 746]]>
          gacaatggga gacaggagct 20
           <![CDATA[ <210> 747]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 747]]>
          agacaatgggagacaggagc 20
           <![CDATA[ <210> 748]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 748]]>
          cagacaatgg gagacaggag 20
           <![CDATA[ <210> 749]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 749]]>
          tcagacaatg ggagacagga 20
           <![CDATA[ <210> 750]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 750]]>
          ctcagacaat gggagacagg 20
           <![CDATA[ <210> 751]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 751]]>
          cagctctcag acaatggggag 20
           <![CDATA[ <210> 752]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Artificial Sequence of]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 752]]>
          gcagctctca gacaatggga 20
           <![CDATA[ <210> 753]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 753]]>
          ggcagctctc agacaatggg 20
           <![CDATA[ <210> 754]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 754]]>
          atatcctagt ggcagctctc 20
           <![CDATA[ <210> 755]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 755]]>
          cccacctagc cttcttatct 20
           <![CDATA[ <210> 756]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 756]]>
          accccacctag ccttcttatc 20
           <![CDATA[ <210> 757]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 757]]>
          cacccaccta gccttcttat 20
           <![CDATA[ <210> 758]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 758]]>
          gcacccacct agccttctta 20
           <![CDATA[ <210> 759]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 759]]>
          agcacccacc tagccttctt 20
           <![CDATA[ <210> 760]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 760]]>
          gagcacccac ctagcccttct 20
           <![CDATA[ <210> 761]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 761]]>
          agagcaccca cctagccttc 20
           <![CDATA[ <210> 762]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 762]]>
          gagagcaccc acctagcctt 20
           <![CDATA[ <210> 763]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 763]]>
          cacaaagcag attgccagca 20
           <![CDATA[ <210> 764]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 764]]>
          tcatagattt ccaaggctgc 20
           <![CDATA[ <210> 765]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 765]]>
          ccaaaactgc aacagaccct 20
           <![CDATA[ <210> 766]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 766]]>
          tccaaaactg caacagaccc 20
           <![CDATA[ <210> 767]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 767]]>
          ttccaaaact gcaacagacc 20
           <![CDATA[ <210> 768]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 768]]>
          ttcccactgc ctaccagccc 20
           <![CDATA[ <210> 769]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 769]]>
          cttcccactg cctaccagcc 20
           <![CDATA[ <210> ]]>770
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 770]]>
          cacacgaatg cacacacatg 20
           <![CDATA[ <210> 771]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 771]]>
          acacacgaat gcacacacat 20
           <![CDATA[ <210> 772]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 772]]>
          gacacacgaa tgcacacaca 20
           <![CDATA[ <210> 773]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 773]]>
          ggacacacga atgcaacacac 20
           <![CDATA[ <210> 774]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 774]]>
          ctcaccattc ctctgtacct 20
           <![CDATA[ <210> 775]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 775]]>
          aagggaggtc ctgaaaccaa 20
           <![CDATA[ <210> 776]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 776]]>
          caagggaggt cctgaaacca 20
           <![CDATA[ <210> 777]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 777]]>
          taaccaactc tcagagccca 20
           <![CDATA[ <210> 778]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 778]]>
          ttaaccaact ctcagagccc 20
           <![CDATA[ <210> 779]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 779]]>
          cttccctcag caacaggcgc 20
           <![CDATA[ <210> 780]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 780]]>
          cctcttgcct cctgtcattt 20
           <![CDATA[ <210> 781]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 781]]>
          ggaaggacct gctgatctaa 20
           <![CDATA[ <210> 782]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 782]]>
          gggaaggacc tgctgatcta 20
           <![CDATA[ <210> 783]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> D]]>NA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 783]]>
          agggaaggac ctgctgatct 20
           <![CDATA[ <210> 784]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 784]]>
          gagggaagga cctgctgatc 20
           <![CDATA[ <210> 785]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 785]]>
          ggagggaagg acctgctgat 20
           <![CDATA[ <210> 786]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 786]]>
          tggagggaag gacctgctga 20
           <![CDATA[ <210> 787]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 787]]>
          ggagatgcag ggaagagtaa 20
           <![CDATA[ <210> 788]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 788]]>
          tggagatgca gggaagagta 20
           <![CDATA[ <210> 789]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 789]]>
          aagggcaact aaccaacaga 20
           <![CDATA[ <210> 790]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 790]]>
          atatctgtaa ccacgccctt 20
           <![CDATA[ <210> 791]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 791]]>
          catatctgta accacgccct 20
           <![CDATA[ <210> 792]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 792]]>
          acatatctgt aaccacgccc 20
           <![CDATA[ <210> 793]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 793]]>
          aacatatctg taaccacgcc 20
           <![CDATA[ <210> 794]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 794]]>
          aatgccccac taagaaacca 20
           <![CDATA[ <210> 795]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 795]]>
          aaatgcccca ctaagaaacc 20
           <![CDATA[ <210> 796]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 796]]>
          gttgtggctt tgatctggtt 20
           <![CDATA[ <210> 797]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 797]]>
          agttgtggct ttgatctggt 20
           <![CDATA[ <210> 798]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 798]]>
          ctcaaggtgc catatctgag 20
           <![CDATA[ <210> 799]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 799]]>
          tctcaaggtg ccatatctga 20
           <![CDATA[ <210> 800]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400]]>> 800]]>
           <br/> <![CDATA[cagggactga cacagagacc 20
           <![CDATA[ <210> 801]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 801]]>
          ccagggactgacacagagac 20
           <![CDATA[ <210> 802]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 802]]>
          gccagggact gacacagaga 20
           <![CDATA[ <210> 803]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 803]]>
          agccagggac tgacacagag 20
           <![CDATA[ <210> 804]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 804]]>
          ggaagtcaac tgctggaaaa 20
           <![CDATA[ <210> 805]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 805]]>
          tggaagtcaa ctgctggaaa 20
           <![CDATA[ <210> 806]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 806]]>
          ctggaagtca actgctggaa 20
           <![CDATA[ <210> 807]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 807]]>
          actggaagtc aactgctgga 20
           <![CDATA[ <210> 808]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 808]]>
          cactggaagt caactgctgg 20
           <![CDATA[ <210> 809]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 809]]>
          gcactggaag tcaactgctg 20
           <![CDATA[ <210> 810]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 810]]>
          tgcactggaa gtcaactgct 20
           <![CDATA[ <210> 811]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 811]]>
          ttgcactgga agtcaactgc 20
           <![CDATA[ <210> 812]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 812]]>
          gctaccatgc tacattgctc 20
           <![CDATA[ <210> 813]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 813]]>
          ggctaccatg ctacattgct 20
           <![CDATA[ <210> 814]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 814]]>
          tgtgtgcttt gatatggctt 20
           <![CDATA[ <210> 815]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 815]]>
          ctttggtctg tgctggctgc 20
           <![CDATA[ <210> 816]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 816]]>
          actttggtct gtgctggctg 20
           <![CDATA[ <210> 817]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 817]]>
          caaaactgtc aactctgcca 20
           <![CDATA[ <210> 818]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 818]]>
          ccaaaactgt caactctgcc 20
           <![CDATA[ <210> 819]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 819]]>
          ctcttcagcc ctagtctctt 20
           <![CDATA[ <210> 820]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 820]]>
          tctcttcagc cctagtctct 20
           <![CDATA[ <210> 821]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 821]]>
          gctaatgggc aagcaaaaaa 20
           <![CDATA[ <210> 822]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 822]]>
          agctaatggg caagcaaaaa 20
           <![CDATA[ <210> 823]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 823]]>
          ggggagggtag gctttgacaa 20
           <![CDATA[ <210> 824]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 824]]>
          ggggagggta ggctttgaca 20
           <![CDATA[ <210> 825]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 825]]>
          tggggagggt aggctttgac 20
           <![CDATA[ <210> 826]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 826]]>
          gtggggaggg taggctttga 20
           <![CDATA[ <210> 827]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 827]]>
          agtgggggagg gtaggctttg 20
           <![CDATA[ <210> 828]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400>]]> 828
          cagtggggag ggtaggcttt 20
           <![CDATA[ <210> 829]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 829]]>
          tcagtgggggagggtaggctt 20
           <![CDATA[ <210> 830]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 830]]>
          aatcagtggg gagggtaggc 20
           <![CDATA[ <210> 831]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 831]]>
          aaatcagtgg ggagggtagg 20
           <![CDATA[ <210> 832]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 832]]>
          gaaatcagtgggggagggtag 20
           <![CDATA[ <210> 833]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 833]]>
          agaaatcagt ggggagggta 20
           <![CDATA[ <210> 834]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 834]]>
          gagaaatcag tggggagggt 20
           <![CDATA[ <210> 835]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 835]]>
          tgagaaatca gtggggaggg 20
           <![CDATA[ <210> 836]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 836]]>
          gtgagaaatc agtgggggagg 20
           <![CDATA[ <210> 837]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 837]]>
          ggtgagaaat cagtggggag 20
           <![CDATA[ <210> 838]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 838]]>
          gggtgagaaa tcagtggggga 20
           <![CDATA[ <210> 839]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 839]]>
          agatgggtca agctgagaaa 20
           <![CDATA[ <210> 840]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 840]]>
          aagatgggtc aagctgagaa 20
           <![CDATA[ <210> 841]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 841]]>
          gaagatgggt caagctgaga 20
           <![CDATA[ <210> 842]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 842]]>
          tgaagatggg tcaagctgag 20
           <![CDATA[ <210> 843]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 843]]>
          gcaacaaggc tgagtgaaga 20
           <![CDATA[ <210> 844]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Artificial Sequence of]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 844]]>
          aacctagcaa caaggctgag 20
           <![CDATA[ <210> 845]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 845]]>
          aaacctagca acaaggctga 20
           <![CDATA[ <210> 846]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 846]]>
          caaacctagc aacaaggctg 20
           <![CDATA[ <210> 847]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 847]]>
          ccaaacctag caacaaggct 20
           <![CDATA[ <210> 848]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 848]]>
          gccaaaccta gcaacaaggc 20
           <![CDATA[ <210> 849]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 849]]>
          agccaaacct agcaacaagg 20
           <![CDATA[ <210> 850]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 850]]>
          aagccaaacc tagcaacaag 20
           <![CDATA[ <210> 851]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 851]]>
          gtttggttgg cctgacttta 20
           <![CDATA[ <210> 852]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 852]]>
          ggtttggttg gcctgacttt 20
           <![CDATA[ <210> 853]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 853]]>
          aggtttggtt ggcctgactt 20
           <![CDATA[ <210> 854]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 854]]>
          taggtttggt tggcctgact 20
           <![CDATA[ <210> 855]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 855]]>
          ttaggtttgg ttggcctgac 20
           <![CDATA[ <210> 856]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400]]>> 856]]>
           <br/> <![CDATA[tttaggtttg gttggcctga 20
           <![CDATA[ <210> 857]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 857]]>
          ttttaggtttggttggcctg 20
           <![CDATA[ <210> 858]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 858]]>
          ggggagtgtg tacatagtgt20
           <![CDATA[ <210> 859]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 859]]>
          aggggaggtgt gtacatagtg 20
           <![CDATA[ <210> 860]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 860]]>
          ggctggttgg tctttggtat 20
           <![CDATA[ <210> 861]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 861]]>
          aggctggttggtctttggta 20
           <![CDATA[ <210> 862]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 862]]>
          cagggaagtg aaagtgaagg 20
           <![CDATA[ <210> 863]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 863]]>
          ggaaacagaa atggctgaga 20
           <![CDATA[ <210> 864]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 864]]>
          aggaaacaga aatggctgag 20
           <![CDATA[ <210> 865]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 865]]>
          tctgcccttg ccaatgccct 20
           <![CDATA[ <210> 866]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 866]]>
          ttctgccctt gccaatgccc 20
           <![CDATA[ <210> 867]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 867]]>
          atcattctgcccttgccaat 20
           <![CDATA[ <210> 868]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 868]]>
          atggtaggtgggcagagaag 20
           <![CDATA[ <210> 869]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 869]]>
          tatggtaggtgggcagagaa 20
           <![CDATA[ <210> 870]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 870]]>
          ttatggtagg tgggcagaga 20
           <![CDATA[ <210> 871]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 871]]>
          ttgctcctgt gatgcctggt 20
           <![CDATA[ <210> 872]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 872]]>
          tttgctcctg tgatgcctgg 20
           <![CDATA[ <210> 873]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 873]]>
          ttcccaccca gatcaacatt 20
           <![CDATA[ <210> 874]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212> ]]>DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 874]]>
          tttcccaccc agatcaacat 20
           <![CDATA[ <210> 875]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 875]]>
          ttttccccacc cagatcaaca 20
           <![CDATA[ <210> 876]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 876]]>
          gtttcagcta ggcaactcaa 20
           <![CDATA[ <210> 877]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 877]]>
          ctgggccaca ctaatcacta 20
           <![CDATA[ <210> 878]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 878]]>
          gggccacact aatcactaga 20
           <![CDATA[ <210> 879]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 879]]>
          cagctaggca actcaatgtg 20
           <![CDATA[ <210> 880]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 880]]>
          ttcagctagg caactcaatg 20
           <![CDATA[ <210> 881]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 881]]>
          ggagaacagt ggaggagagt 20
           <![CDATA[ <210> 882]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 882]]>
          ggggacactc atctaaggaa 20
           <![CDATA[ <210> 883]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 883]]>
          tacaagacaa ttccagccca 20
           <![CDATA[ <210> 884]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 884]]>
          tactgggcca cactaatcac 20
           <![CDATA[ <210> 885]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 885]]>
          agaacagtgg aggagagtgg 20
           <![CDATA[ <210> 886]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 886]]>
          agagaggatc agccaggcac 20
           <![CDATA[ <210> 887]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 887]]>
          agagtggagg atggggacac 20
           <![CDATA[ <210> 888]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 888]]>
          tcactggatg gttgggagca 20
           <![CDATA[ <210> 889]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 889]]>
          cacaggggca tatcaaagtc 20
           <![CDATA[ <210> 890]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 890]]>
          tactccccag ataagcctca 20
           <![CDATA[ <210> 891]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 891]]>
          gcttgggctg gacttttttg 20
           <![CDATA[ <210> 892]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 892]]>
          ccccagataa gcctcagtct 20
           <![CDATA[ <210> 893]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 893]]>
          cactggatgg ttgggagcag 20
           <![CDATA[ <210> 894]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 894]]>
          caagtgccag accctttcat 20
           <![CDATA[ <210> 895]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 895]]>
          ttgttttgct gctcgaatca 20
           <![CDATA[ <210> 896]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 896]]>
          tgtgtctatg cctgtggatg 20
           <![CDATA[ <210> 897]]>
           <![CDATA[ <211> ]]>20
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 897]]>
          gtgcatgttc tttccactct 20
           <![CDATA[ <210> 898]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 898]]>
          tccccagata agcctcagtc 20
           <![CDATA[ <210> 899]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 899]]>
          ggagcaccaa ccaaccagag 20
           <![CDATA[ <210> 900]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 900]]>
          aagacacaat acctgccttc 20
           <![CDATA[ <210> 901]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 901]]>
          agagggttcc aaaggagcac 20
           <![CDATA[ <210> 902]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 902]]>
          aagtgccaga ccctttcatt 20
           <![CDATA[ <210> 903]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 903]]>
          tccaagtgcc agaccctttc 20
           <![CDATA[ <210> 904]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 904]]>
          gattgttttg ctgctcgaat 20
           <![CDATA[ <210> 905]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 905]]>
          gtgtctatgc ctgtggatga 20
           <![CDATA[ <210> 906]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 906]]>
          tagttgccac cagagaatgt 20
           <![CDATA[ <210> 907]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 907]]>
          cttggtgttg tctgaaagca 20
           <![CDATA[ <210> 908]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 908]]>
          gccagataaa acaaggccct 20
           <![CDATA[ <210> 909]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213>]]> Artificial Sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 909]]>
          cagcagcaat gggatccacc 20
           <![CDATA[ <210> 910]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 910]]>
          tgaactgtgc ttgggggttgt 20
           <![CDATA[ <210> 911]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 911]]>
          tgtactgatt tgtgcctggc 20
           <![CDATA[ <210> 912]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 912]]>
          gatcaccttc aaaccccttt 20
           <![CDATA[ <210> 913]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400]]>> 913]]>
           <br/> <![CDATA[aagaggtcac tggatggttg 20
           <![CDATA[ <210> 914]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 914]]>
          attgttttgc tgctcgaatc 20
           <![CDATA[ <210> 915]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 915]]>
          tagggatcac cttcaaaccc 20
           <![CDATA[ <210> 916]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 916]]>
          ttgcacaagt aggcagcaca 20
           <![CDATA[ <210> 917]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 917]]>
          cagagggttc caaaggagca 20
           <![CDATA[ <210> 918]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 918]]>
          ggcagttgtg gtagggggttc 20
           <![CDATA[ <210> 919]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 919]]>
          ttgaactgtg cttgggggttg 20
           <![CDATA[ <210> 920]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> ]]>Artificial sequence
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 920]]>
          gaggaagaat gggcaatgtg 20
           <![CDATA[ <210> 921]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 921]]>
          ttgggctgga cttttttgca 20
           <![CDATA[ <210> 922]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 922]]>
          ttccaagtgc cagacccttt 20
           <![CDATA[ <210> 923]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223>]]> Description of Artificial Sequence: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 923]]>
          tgggctggac ttttttgcat 20
           <![CDATA[ <210> 924]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 924]]>
          cccttttaga cccctgaagt 20
           <![CDATA[ <210> 925]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 925]]>
          agcagcaatg ggatccacca 20
           <![CDATA[ <210> 926]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 926]]>
          tcccttttag accccctgaag 20
           <![CDATA[ <210> 927]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 927]]>
          agagggggaaa atatgggggc 20
           <![CDATA[ <210> 928]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 928]]>
          gcagagagga gaacagtgga 20
           <![CDATA[ <210> 929]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 929]]>
          gaaaatatgg gggcaacaga 20
           <![CDATA[ <210> 930]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 930]]>
          gggatcacct tcaaacccct 20
           <![CDATA[ <210> 931]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 931]]>
          tagaggctga caagggtaag 20
           <![CDATA[ <210> 932]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 932]]>
          acaagtaggc agcacaggtt 20
           <![CDATA[ <210> 933]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 933]]>
          gtctatgcctgtggatgaga 20
           <![CDATA[ <210> 934]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 934]]>
          ggctgacaag ggtaagaggg 20
           <![CDATA[ <210> 935]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 935]]>
          atggggacac tcatctaagg 20
           <![CDATA[ <210> 936]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>]]> DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 936]]>
          ggatcacctt caaacccctt 20
           <![CDATA[ <210> 937]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 937]]>
          agggttccaa aggagcacca 20
           <![CDATA[ <210> 938]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 938]]>
          aggcactagg agaccctggg 20
           <![CDATA[ <210> 939]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 939]]>
          agtgaacaga ttccagcaga 20
           <![CDATA[ <210> 940]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 940]]>
          actgtgcttg gggttgtttc 20
           <![CDATA[ <210> 941]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 941]]>
          gggttccaaa ggagcaccaa 20
           <![CDATA[ <210> 942]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 942]]>
          gcagcagcaa tgggatccac 20
           <![CDATA[ <210> 943]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 943]]>
          gggaacccctt ctgtcatcat 20
           <![CDATA[ <210> 944]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 944]]>
          ggaagaggaa aagcttggag 20
           <![CDATA[ <210> 945]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 945]]>
          ctgggaaccc ttctgtcatc 20
           <![CDATA[ <210> 946]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 946]]>
          ggcagggcta gacaaaatgg 20
           <![CDATA[ <210> 947]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 947]]>
          acccttctgt catcat gcat 20
           <![CDATA[ <210> 948]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 948]]>
          ctccccagat aagcctcagt 20
           <![CDATA[ <210> 949]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 949]]>
          cagataaaac aaggccctga 20
           <![CDATA[ <210> 950]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 950]]>
          gggctggact tttttgcatg 20
           <![CDATA[ <210> 951]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 951]]>
          tttgcacaag taggcagcac 20
           <![CDATA[ <210> 952]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 952]]>
          ctttgaactg tgcttggggt 20
           <![CDATA[ <210> 953]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 953]]>
          aaggacaaga ggctttctcc 20
           <![CDATA[ <210> 954]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 954]]>
          gaactgtgct tggggttgtt 20
           <![CDATA[ <210> 955]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 955]]>
          ctttgcacaa gtaggcagca 20
           <![CDATA[ <210> 956]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 956]]>
          gtctgagaggagttacacca 20
           <![CDATA[ <210> 957]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 957]]>
          aggacaagag gctttctcct 20
           <![CDATA[ <210> 958]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 958]]>
          aggaagaatg ggcaatgtgt 20
           <![CDATA[ <210> 959]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 959]]>
          agtctgagag gagttacacc 20
           <![CDATA[ <210> 960]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 960]]>
          gagggttcca aaggagcacc 20
           <![CDATA[ <210> 961]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 961]]>
          ccagataaaa caaggccctg 20
           <![CDATA[ <210> 962]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 962]]>
          gctgggagag aaaagcagag 20
           <![CDATA[ <210> 963]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 963]]>
          gtactgattt gtgcctggca 20
           <![CDATA[ <210> 964]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 964]]>
          gcactaggag accctgggac 20
           <![CDATA[ <210> 965]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 965]]>
          gtactcccca gataagcctc 20
           <![CDATA[ <210> 966]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 966]]>
          cagagggga aatatggggg 20
           <![CDATA[ <210> 967]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 967]]>
          tgtgctgaac accattatg 20
           <![CDATA[ <210>]]> 968
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 968]]>
          tcaaacgaca aattccagct 20
           <![CDATA[ <210> 969]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 969]]>
          gctgacaagg gtaagaggga 20
           <![CDATA[ <210> 970]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 970]]>
          tcatcatgca taagcagcct 20
           <![CDATA[ <210> 971]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 971]]>
          agcagagagg agaacagtgg 20
           <![CDATA[ <210> 972]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 972]]>
          atcatgcata agcagcctga 20
           <![CDATA[ <210> 973]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 973]]>
          ttgtaggtca tgggaagtca 20
           <![CDATA[ <210> 974]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 974]]>
          tgtcatcatg cataagcagc 20
           <![CDATA[ <210> 975]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 975]]>
          gaacccttct gtcatcatgc 20
           <![CDATA[ <210> 976]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 976]]>
          tgtaggtcat gggaagtcat 20
           <![CDATA[ <210> 977]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 977]]>
          catcatgcat aagcagcctg 20
           <![CDATA[ <210> 978]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 978]]>
          tttgaactgt gcttgggggtt 20
           <![CDATA[ <210> 979]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 979]]>
          tactgatttg tgcctggcat 20
           <![CDATA[ <210> 980]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 980]]>
          gtggaggatggggacactca 20
           <![CDATA[ <210> 981]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 981]]>
          aattccaagt gccagaccct 20
           <![CDATA[ <210> 982]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 982]]>
          tcatgcataa gcagcctgag 20
           <![CDATA[ <210> 983]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 983]]>
          atgcataagc agcctgagtc 20
           <![CDATA[ <210> 984]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 984]]>
          ctgacaaggg taagaggggag 20
           <![CDATA[ <210> 985]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 985]]>
          aagcctgaca tagccacaca 20
           <![CDATA[ <210> 986]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 986]]>
          tgcataagca gcctgagtct 20
           <![CDATA[ <210> 987]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 987]]>
          aagaggctat tgagcaccct 20
           <![CDATA[ <210> 988]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 988]]>
          aagcagcctg agtcttagat 20
           <![CDATA[ <210> 989]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 989]]>
          aggctttaac atgtgctgaa 20
           <![CDATA[ <210> 990]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 990]]>
          agaggaagaa tgggcaatgt 20
           <![CDATA[ <210> 991]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 991]]>
          ggaaggactt gggtcttact 20
           <![CDATA[ <210> 992]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 992]]>
          gaagaatggg caatgtgtct 20
           <![CDATA[ <210> 993]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 993]]>
          agacaggcac taggagaccc 20
           <![CDATA[ <210> 994]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 994]]>
          actgatttgt gcctggcatc 20
           <![CDATA[ <210> 995]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 995]]>
          cagcagagat tatggcagag 20
           <![CDATA[ <210> 996]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 996]]>
          attccaagtg ccagaccctt 20
           <![CDATA[ <210> 997]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 997]]>
          aagtaggcag cacaggtttt 20
           <![CDATA[ <210> 998]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 998]]>
          ctcaactcag gctagctact 20
           <![CDATA[ <210> 999]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 999]]>
          ggctggacttttttgcatgg 20
           <![CDATA[ <210> 1000]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1000]]>
          aaaatatggg ggcaacagag 20
           <![CDATA[ <210> 1001]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1001]]>
          ggaagaatgg gcaatgtgtc 20
           <![CDATA[ <210> 1002]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Artificial Sequence of]]> Description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 1002]]>
          tgtgaatcca tttgtccagc 20
           <![CDATA[ <210> 1003]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1003]]>
          gcataagcag cctgagtctt 20
           <![CDATA[ <210> 1004]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1004]]>
          gttccaaagg agcaccaacc 20
           <![CDATA[ <210> 1005]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1005]]>
          ccaaccaacc agggggaaa 20
           <![CDATA[ <210> 1006]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1006]]>
          ggcctggaga atagggagag 20
           <![CDATA[ <210> 1007]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1007]]>
          ggaacccttc tgtcatcatg 20
           <![CDATA[ <210> 1008]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1008]]>
          cctggtgtgt gcaaacatgt 20
           <![CDATA[ <210> 1009]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1009]]>
          cctttgttcc cacatcacat 20
           <![CDATA[ <210> 1010]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1010]]>
          caaggaaact acagcccaga 20
           <![CDATA[ <210> 1011]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1011]]>
          cagttgtggt aggggttctt 20
           <![CDATA[ <210> 1012]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1012]]>
          gaggctgaca agggtaagag 20
           <![CDATA[ <210> 1013]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1013]]>
          agaggctatt gagcaccctt 20
           <![CDATA[ <210> 1014]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1014]]>
          aaggaaacta cagcccagac 20
           <![CDATA[ <210> 1015]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1015]]>
          ggggctttga actgtgcttg 20
           <![CDATA[ <210> 1016]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1016]]>
          agcctgacat agccacacag 20
           <![CDATA[ <210> 1017]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1017]]>
          tagattgttttgctgctcga 20
           <![CDATA[ <210> 1018]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1018]]>
          aggaaggact tgggtcttac 20
           <![CDATA[ <210> 1019]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1019]]>
          tctggctaga aatgtaggca 20
           <![CDATA[ <210> 1020]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1020]]>
          caatgggatc caccacagca 20
           <![CDATA[ <210> 1021]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1021]]>
          agggccacaa ataggtctct 20
           <![CDATA[ <210> 1022]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1022]]>
          gcagttgtgg taggggttct 20
           <![CDATA[ <210> 1023]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1023]]>
          cctctggtgc ctctagtttt 20
           <![CDATA[ <210> 1024]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1024]]>
          ggctttaaca tgtgctgaac 20
           <![CDATA[ <210> 1025]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1025]]>
          aggagggggc tttgaactgt 20
           <![CDATA[ <210> 1026]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1026]]>
          taaaccctgc tagccagaag 20
           <![CDATA[ <210> 1027]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1027]]>
          accaaccaac cagaggggaa 20
           <![CDATA[ <210> 1028]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1028]]>
          tcaactcagg ctagctactt 20
           <![CDATA[ <210> 1029]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1029]]>
          gccaggcgag aatttgcttt 20
           <![CDATA[ <210> 1030]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1030]]>
          ccctgctagc cagaagagat 20
           <![CDATA[ <210> 1031]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1031]]>
          cagagaggag aacagtggag 20
           <![CDATA[ <210> 1032]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1032]]>
          gcaaggaaac tacagcccag 20
           <![CDATA[ <210> 1033]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1033]]>
          gttgccacca gagaatgtga 20
           <![CDATA[ <210> 1034]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1034]]>
          gaggctattg agcaccctta 20
           <![CDATA[ <210> 1035]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1035]]>
          gggggctttg aactgtgctt 20
           <![CDATA[ <210> 1036]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1036]]>
          aactgatgcc tctacctcca 20
           <![CDATA[ <210> 1037]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1037]]>
          ggagggggct ttgaactgtg 20
           <![CDATA[ <210> 1038]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1038]]>
          ggccagaaac cacttagaac 20
           <![CDATA[ <210> 1039]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1039]]>
          agttgccacc agagaatgtg 20
           <![CDATA[ <210> 1040]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Human process]]> column description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 1040]]>
          ttgccaccag agaatgtgaa 20
           <![CDATA[ <210> 1041]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1041]]>
          taaattccaa gtgccagacc 20
           <![CDATA[ <210> 1042]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1042]]>
          atgtactgat ttgtgcctgg 20
           <![CDATA[ <210> 1043]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1043]]>
          ggttccaaag gagcaccaac 20
           <![CDATA[ <210> 1044]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1044]]>
          actagcatga gagcacccac 20
           <![CDATA[ <210> 1045]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1045]]>
          ggacaagagg ctttctcctt 20
           <![CDATA[ <210> 1046]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1046]]>
          caagtaggca gcacaggttt 20
           <![CDATA[ <210> 1047]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1047]]>
          ctgacatagc cacacagccc 20
           <![CDATA[ <210> 1048]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1048]]>
          cctgacatag ccacacagcc 20
           <![CDATA[ <210> 1049]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>]]> DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1049]]>
          gtgttgtctg aaagcaggaa 20
           <![CDATA[ <210> 1050]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1050]]>
          aggagagcat gttatccctt 20
           <![CDATA[ <210> 1051]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1051]]>
          agattgtttt gctgctcgaa 20
           <![CDATA[ <210> 1052]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1052]]>
          aaattccaag tgccagaccc 20
           <![CDATA[ <210> 1053]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1053]]>
          ttccaaagga gcaccaacca 20
           <![CDATA[ <210> 1054]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1054]]>
          actccagtaa ccaccacaat 20
           <![CDATA[ <210> 1055]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1055]]>
          gctttgaact gtgcttgggg 20
           <![CDATA[ <210> 1056]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1056]]>
          catagatttc caaggctgca 20
           <![CDATA[ <210> 1057]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1057]]>
          tagggccaca aataggtctc 20
           <![CDATA[ <210> 1058]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1058]]>
          gggccacaaa taggtctctt 20
           <![CDATA[ <210> 1059]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1059]]>
          gccaccagag aatgtgaaaa 20
           <![CDATA[ <210> 1060]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1060]]>
          tccaaggctg caaaagctaa 20
           <![CDATA[ <210> 1061]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1061]]>
          caggcaagag atctggctag 20
           <![CDATA[ <210> 1062]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213]]>> Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1062]]>
          ttagggccac aaataggtct 20
           <![CDATA[ <210> 1063]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220]]>>]]>
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1063]]>
          agcatgagag cacccaccta 20
           <![CDATA[ <210> 1064]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1064]]>
          acatggccag aaaccactta 20
           <![CDATA[ <210> 1065]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1065]]>
          aacatgtgct gaacacccat 20
           <![CDATA[ <210> 1066]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1066]]>
          aggctgacaa gggtaagagg 20
           <![CDATA[ <210> 1067]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1067]]>
          gatctgtcca ccttagcctc 20
           <![CDATA[ <210> 1068]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1068]]>
          tgtactcccc agataagcct 20
           <![CDATA[ <210> 1069]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1069]]>
          aagcagagag gagaacagtg 20
           <![CDATA[ <210> 1070]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1070]]>
          aggaaactac agcccagaca 20
           <![CDATA[ <210> 1071]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1071]]>
          ccagcagaga ttatggcaga 20
           <![CDATA[ <210> 1072]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1072]]>
          acaagcaaag tgaccaagag 20
           <![CDATA[ <210> 1073]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1073]]>
          aactccagta accaccacaa 20
           <![CDATA[ <210> 1074]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1074]]>
          ttgtactccc cagataagcc 20
           <![CDATA[ <210> 1075]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1075]]>
          caagcaaagt gaccaagaga 20
           <![CDATA[ <210> 1076]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1076]]>
          agaggagtta caccatgtca 20
           <![CDATA[ <210> 1077]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1077]]>
          aacaagcaaa gtgaccaaga 20
           <![CDATA[ <210> 1078]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1078]]>
          ataaaccctg ctagccagaa 20
           <![CDATA[ <210> 1079]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1079]]>
          aactgtgcttggggttgttt 20
           <![CDATA[ <210> 1080]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1080]]>
          cttgggtctt actccctggt 20
           <![CDATA[ <210> 1081]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1081]]>
          ttagaggctg acaagggtaa 20
           <![CDATA[ <210> 1082]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1082]]>
          ggctttgaac tgtgcttggg 20
           <![CDATA[ <210> 1083]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1083]]>
          caggaaggac ttgggtctta 20
           <![CDATA[ <210> 1084]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1084]]>
          gctgaggcac tgtgaccctg 20
           <![CDATA[ <210> 1085]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1085]]>
          tgccaggcga gaatttgctt 20
           <![CDATA[ <210> 1086]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1086]]>
          tctatgcctg tggatgagag 20
           <![CDATA[ <210> 1087]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1087]]>
          gcatgagagc accccacctag 20
           <![CDATA[ <210> 1088]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Human process]]> column description: Synthesis
                Oligonucleotides
           <![CDATA[ <400> 1088]]>
          ccttgcccaa ctggtccttt 20
           <![CDATA[ <210> 1089]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1089]]>
          tccagcagag attatggcag 20
           <![CDATA[ <210> 1090]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1090]]>
          ccaggcgaga atttgctttt 20
           <![CDATA[ <210> 1091]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1091]]>
          atgggagaca ggagctaatg 20
           <![CDATA[ <210> 1092]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1092]]>
          ttctgcgtat gggcatctcc 20
           <![CDATA[ <210> 1093]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1093]]>
          acatgtgctg aacacccatt 20
           <![CDATA[ <210> 1094]]>
           <![CDATA[ <211]]>> 20]]>
           <br/> &lt;![CDATA[ &lt;212&gt;DNA]]&gt;
           <br/> &lt;![CDATA[ &lt;213&gt; Artificial Sequence]]&gt;
           <br/>
           <br/> &lt;![CDATA[ &lt;220&gt;]]&gt;
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1094]]>
          tgcctctacc tccagcaagc 20
           <![CDATA[ <210> 1095]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1095]]>
          tttctgcgta tgggcatctc 20
           <![CDATA[ <210> 1096]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1096]]>
          tgaacagatt ccagcagaga 20
           <![CDATA[ <210> 1097]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>]]> DNA
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1097]]>
          tgtgtttcaa ctgtggggctt 20
           <![CDATA[ <210> 1098]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1098]]>
          catgccaggc gagaatttgc 20
           <![CDATA[ <210> 1099]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1099]]>
          gagaggaaga atgggcaatg 20
           <![CDATA[ <210> 1100]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1100]]>
          aggacttggg tcttactccc 20
           <![CDATA[ <210> 1101]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1101]]>
          gctactagca tgagagcacc 20
           <![CDATA[ <210> 1102]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1102]]>
          atgccaggcg agaatttgct 20
           <![CDATA[ <210> 1103]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1103]]>
          aagacaggca ctaggagacc 20
           <![CDATA[ <210> 1104]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1104]]>
          gacatagcca cacagcccaa 20
           <![CDATA[ <210> 1105]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1105]]>
          tctcaactca ggctagctac 20
           <![CDATA[ <210> 1106]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1106]]>
          ggaaaccaca gtgctatgaa 20
           <![CDATA[ <210> 1107]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1107]]>
          acatagccacacagcccaag 20
           <![CDATA[ <210> 1108]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1108]]>
          aggggggcttt gaactgtgct 20
           <![CDATA[ <210> 1109]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1109]]>
          aggagttaca ccatgtcagc 20
           <![CDATA[ <210> 1110]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1110]]>
          atggccagaa accacttaga 20
           <![CDATA[ <210> 1111]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1111]]>
          caggagagca tgttatccct 20
           <![CDATA[ <210> 1112]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1112]]>
          tggcagctct cagacaatgg 20
           <![CDATA[ <210> 1113]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1113]]>
          gaaggaactc cagtaaccac 20
           <![CDATA[ <210> 1114]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1]]>114
          aggcaagaga tctggctaga 20
           <![CDATA[ <210> 1115]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1115]]>
          gtaggcagca caggttttct 20
           <![CDATA[ <210> 1116]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1116]]>
          gggctttgaa ctgtgcttgg 20
           <![CDATA[ <210> 1117]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1117]]>
          gtgaacagat tccagcagag 20
           <![CDATA[ <210> 1118]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1118]]>
          gcttcccaag agtatcagga 20
           <![CDATA[ <210> 1119]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1119]]>
          ggagcttccc aagagtatca 20
           <![CDATA[ <210> 1120]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1120]]>
          ggcaagagat ctggctagaa 20
           <![CDATA[ <210> 1121]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1121]]>
          catgtgctga accacccatta 20
           <![CDATA[ <210> 1122]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1122]]>
          ctgggagaga aaagcagaga 20
           <![CDATA[ <210> 1123]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1123]]>
          agcttcccaa gagtatcagg 20
           <![CDATA[ <210> 1124]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1124]]>
          ggacttgggt cttactccct 20
           <![CDATA[ <210> 1125]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1125]]>
          gtggcagctc tcagacaatg 20
           <![CDATA[ <210> 1126]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1126]]>
          tgtctatgcc tgtggatgag 20
           <![CDATA[ <210> 1127]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1127]]>
          ggagttacac catgtcagct 20
           <![CDATA[ <210> 1128]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1128]]>
          gacaggcact aggagaccct 20
           <![CDATA[ <210> 1129]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1129]]>
          ccaaggctgc aaaagctaaa 20
           <![CDATA[ <210> 1130]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1130]]>
          catggccaga aaccacttag 20
           <![CDATA[ <210> 1131]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1131]]>
          agtaggcagcacaggttttc 20
           <![CDATA[ <210> 1132]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1132]]>
          cctgctagcc agaagagatt 20
           <![CDATA[ <210> 1133]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1133]]>
          gcatgccttt gctcacctgt 20
           <![CDATA[ <210> 1134]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1134]]>
          tgagaggagt tacaccatgt 20
           <![CDATA[ <210> 1135]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1135]]>
          atgagagcac ccacctagcc 20
           <![CDATA[ <210> 1136]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1136]]>
          tgggagagaa aagcagagat 20
           <![CDATA[ <210> 1137]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1137]]>
          gcctgacata gccacacagc 20
           <![CDATA[ <210> 1138]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1138]]>
          tagccacaca gcccaagacc 20
           <![CDATA[ <210> 1139]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1139]]>
          agcacaggttttctgacttt 20
           <![CDATA[ <210> 1140]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1140]]>
          aatgggagac aggagctaat 20
           <![CDATA[ <210> 1141]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1141]]>
          tgccaccaga gaatgtgaaa 20
           <![CDATA[ <210> 1142]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1142]]>
          tagcatgaga gcacccacct 20
           <![CDATA[ <210> 1143]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1143]]>
          actgatgcct ctacctccag 20
           <![CDATA[ <210> 1144]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1144]]>
          catgagagca cccacctagc 20
           <![CDATA[ <210> 1145]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1145]]>
          ctagcatgag agcacccacc 20
           <![CDATA[ <210> 1146]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1146]]>
          ccagaggggga aaatatgggg 20
           <![CDATA[ <210> 1147]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1147]]>
          gccaagccca aacactaaga 20
           <![CDATA[ <210> 1148]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1148]]>
          ggcttggggct ggactttttt 20
           <![CDATA[ <210> 1149]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1149]]>
          tactagcatg agagcaccca 20
           <![CDATA[ <210> 1150]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1150]]>
          tccaattagc tgccaggagt 20
           <![CDATA[ <210> 1151]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1151]]>
          agccaagccc aaacactaag 20
           <![CDATA[ <210> 1152]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1152]]>
          tgaggcactg tgaccctggg 20
           <![CDATA[ <210> 1153]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1153]]>
          ctactagcat gagagcaccc 20
           <![CDATA[ <210> 1154]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1154]]>
          tgagagcacc cacctagcct 20
           <![CDATA[ <210> 1155]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1155]]>
          tggaaaccac agtgctatga 20
           <![CDATA[ <210> 1156]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1156]]>
          gttgtctgaa agcaggaagg 20
           <![CDATA[ <210> 1157]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1157]]>
          gtgtttcaac tgtggggctta 20
           <![CDATA[ <210> 1158]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1158]]>
          tgacatagcc acacagccca 20
           <![CDATA[ <210> 1159]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1159]]>
          ctgaactgat gcctctacct 20
           <![CDATA[ <210> 1160]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1160]]>
          tgaactgatg cctctacctc 20
           <![CDATA[ <210> 1161]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1161]]>
          cagcacaggt tttctgactt 20
           <![CDATA[ <210> 1162]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1162]]>
          ccagtgccaa agtaagagga 20
           <![CDATA[ <210> 1163]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1163]]>
          ctttttggag ttctggaggc 20
           <![CDATA[ <210> 1164]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1164]]>
          atcagctgag gcactgtgac 20
           <![CDATA[ <210> 1165]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1165]]>
          tctgtagcca aatgaatggg 20
           <![CDATA[ <210> 1166]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1166]]>
          taacatgtgc tgaacaccca 20
           <![CDATA[ <210> 1167]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1167]]>
          accagagggg aaaatatggg 20
           <![CDATA[ <210> 1168]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1168]]>
          ctgatgcctc tacctccagc 20
           <![CDATA[ <210> 1169]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1169]]>
          aacgacaaat tccagcttct 20
           <![CDATA[ <210> 1170]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223]]>> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1170]]>
          catagccaca cagcccaaga 20
           <![CDATA[ <210> 1171]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1171]]>
          ttcctggaaa ccacagtgct 20
           <![CDATA[ <210> 1172]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1172]]>
          tggaggatgg ggacactcat 20
           <![CDATA[ <210> 1173]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1173]]>
          tagctaatgg gcaagcaaaa 20
           <![CDATA[ <210> 1174]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1174]]>
          cctagtggca gctctcagac 20
           <![CDATA[ <210> 1175]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1175]]>
          tggcctggag aatagggaga 20
           <![CDATA[ <210> 1176]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1176]]>
          tcagctgagg cactgtgacc 20
           <![CDATA[ <210> 1177]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1177]]>
          aaccaaccag aggggaaaat 20
           <![CDATA[ <210> 1178]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220]]>>]]>
           <br/> &lt;![CDATA[ &lt;223&gt; Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1178]]>
          acaggagagc atgttatccc 20
           <![CDATA[ <210> 1179]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1179]]>
          cattatcatg gttgccccaga 20
           <![CDATA[ <210> 1180]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1180]]>
          ctttctgcgt atgggcatct 20
           <![CDATA[ <210> 1181]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1181]]>
          ttgacggatcagacactctt 20
           <![CDATA[ <210> 1182]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1182]]>
          tttgacggat cagacactct 20
           <![CDATA[ <210> 1183]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1183]]>
          aactacagcc cagacatgtc 20
           <![CDATA[ <210> 1184]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1184]]>
          tggtgtgtgc aaacatgtat 20
           <![CDATA[ <210> 1185]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1185]]>
          agtgccaaag taagaggaga 20
           <![CDATA[ <210> 1186]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1186]]>
          accaaccaga ggggaaaata 20
           <![CDATA[ <210> 1187]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1187]]>
          ctccaattag ctgccaggag 20
           <![CDATA[ <210> 1188]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1188]]>
          gctggacttttttgcatgga 20
           <![CDATA[ <210> 1189]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1189]]>
          tggagcttcc caagagtatc 20
           <![CDATA[ <210> 1190]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1190]]>
          taccttgccc aactggtcct 20
           <![CDATA[ <210> 1191]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1191]]>
          tggccagaaa ccacttagaa 20
           <![CDATA[ <210> 1192]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1192]]>
          tttgctttct gcgtatgggc 20
           <![CDATA[ <210> 1193]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1193]]>
          ttttgacgga tcagacactc 20
           <![CDATA[ <210> 1194]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1194]]>
          tatcctagtg gcagctctca 20
           <![CDATA[ <210> 1195]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1195]]>
          tcctggaaac cacagtgcta 20
           <![CDATA[ <210> 1196]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1196]]>
          atagccaacac agcccaagac 20
           <![CDATA[ <210> 1197]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1197]]>
          tgttgtctga aagcaggaag 20
           <![CDATA[ <210> 1198]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1198]]>
          ttccagcaga gattatggca 20
           <![CDATA[ <210> 1199]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1199]]>
          ttaacatgtg ctgaacaccc 20
           <![CDATA[ <210> 1200]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1200]]>
          tgacaagggt aagagggagg 20
           <![CDATA[ <210> 1201]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1201]]>
          cctggaaacc acagtgctat 20
           <![CDATA[ <210> 1202]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1202]]>
          ggaaactaca gcccagacat 20
           <![CDATA[ <210> 1203]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1203]]>
          ccttcctgcc tcacggatgt 20
           <![CDATA[ <210> 1204]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1204]]>
          ccaattagct gccaggaggtg 20
           <![CDATA[ <210> 1205]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1205]]>
          aaaaggaaca tcaaaggcgc 20
           <![CDATA[ <210> 1206]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1206]]>
          ctgctagcca gaagagattg 20
           <![CDATA[ <210> 1207]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1207]]>
          tgatcttggg caaaagtgtg 20
           <![CDATA[ <210> 1208]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1208]]>
          gttagtgagc caaggcccag 20
           <![CDATA[ <210> 1209]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1209]]>
          gacttgggtc ttactccctg 20
           <![CDATA[ <210> 1210]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1210]]>
          aaggacttgg gtcttactcc 20
           <![CDATA[ <210> 1211]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1211]]>
          gagggggctt tgaactgtgc 20
           <![CDATA[ <210> 1212]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1212]]>
          gaaactacag cccagacatg 20
           <![CDATA[ <210> 1213]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1213]]>
          gcctctacct ccagcaagca 20
           <![CDATA[ <210> 1214]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1214]]>
          agacattcac tctgtgctca 20
           <![CDATA[ <210> 1215]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1215]]>
          agctgaggca ctgtgaccct 20
           <![CDATA[ <210> 1216]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1216]]>
          cttcctgcct cacggatgtc 20
           <![CDATA[ <210> 1217]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1217]]>
          gtgaagatgg gtcaagctga 20
           <![CDATA[ <210> 1218]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1218]]>
          acttgtgacc ttcagtacca 20
           <![CDATA[ <210> 1219]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1219]]>
          aacaaggccc tgagtaacaa 20
           <![CDATA[ <210> 1220]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1220]]>
          aaacaaggcc ctgagtaaca 20
           <![CDATA[ <210> 1221]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1221]]>
          ctggcctgga gaataggggag 20
           <![CDATA[ <210> 1222]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1222]]>
          caaaaggaac atcaaaggcg 20
           <![CDATA[ <210> 1223]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1223]]>
          gcagcacagg ttttctgact 20
           <![CDATA[ <210> 1224]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1224]]>
          ctggaaacca cagtgctatg 20
           <![CDATA[ <210> 1225]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1225]]>
          aaaatgcagg tttgtagggc 20
           <![CDATA[ <210> 1226]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1226]]>
          accttgccca actggtcctt 20
           <![CDATA[ <210> 1227]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1227]]>
          tctgcgtatg ggcatctcca 20
           <![CDATA[ <210> 1228]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1228]]>
          ttcctgcctc acggatgtcc 20
           <![CDATA[ <210> 1229]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1229]]>
          ttatcatggt tgccccagaag 20
           <![CDATA[ <210> 1230]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1230]]>
          gcctggagaa tagggagaga 20
           <![CDATA[ <210> 1231]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1231]]>
          ctagtggcag ctctcagaca 20
           <![CDATA[ <210> 1232]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1232]]>
          gatcttgggc aaaagtgtgtgt 20
           <![CDATA[ <210> 1233]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1233]]>
          aaactacagc ccagacatgt 20
           <![CDATA[ <210> 1234]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1234]]>
          atgtacatgg ccagaaacca 20
           <![CDATA[ <210> 1235]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1235]]>
          ttttgctttc tgcgtatggg 20
           <![CDATA[ <210> 1236]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1236]]>
          ctggtgtgtg caaacatgta 20
           <![CDATA[ <210> 1237]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1237]]>
          ggcagcacag gttttctgac 20
           <![CDATA[ <210> 1238]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1238]]>
          atcctagtgg cagctctcag 20
           <![CDATA[ <210> 1239]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1239]]>
          tgtacatggc cagaaaccac 20
           <![CDATA[ <210> 1240]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1240]]>
          tatgctgtgc ctttttgctt 20
           <![CDATA[ <210> 1241]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1241]]>
          taagccagaa acagaaaggc 20
           <![CDATA[ <210> 1242]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1242]]>
          tgatgcctct acctccagca 20
           <![CDATA[ <210> 1243]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1243]]>
          ggagggtagg ctttgacaaa 20
           <![CDATA[ <210> 1244]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1244]]>
          ggatggatga atgcatggat 20
           <![CDATA[ <210> 1245]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1245]]>
          aaagacaggc actaggagac 20
           <![CDATA[ <210> 1246]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1246]]>
          caattagctg ccaggagtgc 20
           <![CDATA[ <210> 1247]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1247]]>
          cagctgaggc actgtgaccc 20
           <![CDATA[ <210> 1248]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1248]]>
          actggcctgg agaataggga 20
           <![CDATA[ <210> 1249]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1249]]>
          gctttctgcg tatgggcatc 20
           <![CDATA[ <210> 1250]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1250]]>
          tcctagtggc agctctcaga 20
           <![CDATA[ <210> 1251]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1251]]>
          gatgcctcta cctccagcaa 20
           <![CDATA[ <210> 1252]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1252]]>
          acaaggccct gagtaacaag 20
           <![CDATA[ <210> 1253]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1253]]>
          atgcctctac ctccagcaag 20
           <![CDATA[ <210> 1254]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1254]]>
          ctgtagccaa atgaatgggc 20
           <![CDATA[ <210> 1255]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1255]]>
          tgggtgagaa atcagtgggg 20
           <![CDATA[ <210> 1256]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1256]]>
          ctgaggcact gtgaccctgg 20
           <![CDATA[ <210> 1257]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1257]]>
          caagtcctgc cctgccactc 20
           <![CDATA[ <210> 1258]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1258]]>
          cagtgccaaa gtaagaggag 20
           <![CDATA[ <210> 1259]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1259]]>
          aaaacaaggc cctgagtaac 20
           <![CDATA[ <210> 1260]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1260]]>
          aagtcctgcc ctgccactct 20
           <![CDATA[ <210> 1261]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1261]]>
          aagattacca cctggggcaca 20
           <![CDATA[ <210> 1262]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1262]]>
          gcaggtttgt agggccttgt 20
           <![CDATA[ <210> 1263]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Description of Artificial Sequence: Synthesis]]>
                Oligonucleotides
           <![CDATA[ <400> 1263]]>
          attccttac accacact 18
           <![CDATA[ <210> 1264]]>
           <![CDATA[ <211> 20]]>
           <![CDATA[ <212>DNA]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <22]]>3> Description of Artificial Sequence: Synthesis]]&gt;
           <br/> <![CDATA[ oligo
           <![CDATA[ <400> 1264]]>
          gttttcatca atatctgcaa 20
          
      

Claims (28)

An oligonucleotide comprising a nucleotide sequence of 15 to 30 contiguous nucleotides, wherein the nucleotide sequence is complementary to a region of the same length as the following nucleotides appearing in SEQ ID NO: 1: a) 16350 to 16450, b) 18926 to 19030, c) 22250 to 22471, d) 22933 to 23079, e) 23408 to 23700, f) 29753 to 29819, g) 38128 to 38158, h) 39852 to 39906, i) 53762 to 53799 or j) 59754 to 59865, Optionally wherein the nucleotide sequence contains no more than 3 mismatches with the region. The oligonucleotide according to claim 1, wherein the nucleotide sequence is 16 to 20 consecutive nucleotides in length. The oligonucleotide according to claim 1 or 2, wherein the nucleotide sequence contains 0, 1 or 2 mismatches with the region. The oligonucleotide according to any one of the preceding claims, wherein the oligonucleotide is single-stranded. The oligonucleotide according to any one of the preceding claims, wherein the nucleotide sequence is selected from SEQ ID NO: 18-40. The oligonucleotide according to any one of the preceding claims, comprising one or more ribonucleotides, one or more deoxyribonucleotides, or a combination of both. The oligonucleotide according to any one of the preceding claims, wherein the oligonucleotide comprises one or more modified nucleotides. The oligonucleotide according to any one of the preceding claims, wherein the one or more modified nucleotides comprise 2'-O-methoxyethyl (2'-MOE) nucleotides, locked nucleic acid ( LNA) nucleotides, bridging nucleic acid (BNA) nucleotides, or any combination thereof. The oligonucleotide according to any one of the preceding claims, wherein all cytosines in the oligonucleotide are 5-methylcytosines. The oligonucleotide of any one of the preceding claims comprising at least 1, 2, 3, 4 or 5 phosphodiester internucleoside linkages. The oligonucleotide of any one of the preceding claims, wherein at least 1, 2, 3, 4 or 5, or all, of the internucleoside linkages are phosphorothioate internucleoside linkages. The oligonucleotide according to any one of claims 7 to 11, wherein the oligonucleotide comprises: i) 5-10-5 MOE spacer; ii) 4-10-4 MOE spacer; iii) 3-10-3 LNA spacer; iv) 3-11-3 LNA spacer; v) 3-2-10-2-3 LNA/MOE spacer; vi) 2-3-10-3-2 BNA/MOE spacer; vii) 3-2-10-2-3 BNA/MOE spacer; or viii) 2-3-10-3-2 LNA/MOE spacer. The oligonucleotide of claim 12, wherein the oligonucleotide comprises: i) 3-2-10-2-3 LNA/MOE spacer; ii) 2-3-10-3-2 BNA/MOE spacer; iii) 3-2-10-2-3 BNA/MOE spacer; or iv) 2-3-10-3-2 LNA/MOE spacer; and wherein the internucleoside linkage between the following nucleosides is associated with a phosphodiester internucleoside linkage: v) 2 and 3, 4 and 5, 16 and 17, and 18 and 19; vi) 2 and 3, 4 and 5, and 16 and 17; vii) 2 and 3, 3 and 4, 4 and 5, 16 and 17, and 17 and 18; or viii) 3 and 4, 4 and 5, 16 and 17, and 17 and 18; And the remainder of the internucleoside linkages are phosphorothioate internucleoside linkages. An oligonucleotide comprising the formula: i) Als Tlo mCls Aeo mCes mCds Tds Tds mCds Ads Ads Ads mCds mCds mCds mCeo Tes Tlo Tls mCl (SEQ ID NO: 34), ii) Abs Tbs mCeo Aeo mCes mCds Tds Tds mCds Ads Ads Ads mCds mCds mCds mCeo Teo Tes Tbs mCb (SEQ ID NO: 20), iii) Als Alo Tls Aeo Ges mCds Ads Tds mCds mCds Tds Tds mCds mCds Ads mCeo Aes mClo mCls Al (SEQ ID NO: 33), iv) Abs Abs Teo Aeo Ges mCds Ads Tds mCds mCds Tds Tds mCds mCds Ads mCeo Aeo mCes mCbs Ab (SEQ ID NO: 19), v) Gbs mCbs Aeo Geo Tes Tds mCds Tds Ads Tds mCds mCds mCds Ads mCds Teo mCeo Aes Tbs mCb (SEQ ID NO: 18), vi) mCbs mCbs Geo Geo Tes Gds mCds mCds Ads Tds Tds Ads mCds Tds mCds mCeo mCeo Tes Tbs Tb (SEQ ID NO: 21), vii) Tbs Tbs Geo mCeo Aes Gds Ads Tds Ads Ads Ads mCds mCds Ads Tds mCeo mCeo mCes Abs mCb (SEQ ID NO: 22), viii) Abs Gbs Teo Geo mCes mCds Ads Gds Ads mCds mCds mCds Tds Tds Tds mCeo Aeo Tes Tbs Ab (SEQ ID NO: 23), ix) mCbs mCbs Aeo Aeo Ges Tds Gds mCds mCds Ads Gds Ads mCds mCds mCds Teo Teo Tes mCbs Ab (SEQ ID NO: 24), x) Gbs mCbs Aeo Geo Aes Tds Ads Ads Ads Ads mCds mCds Ads Tds mCds mCds mCeo Aeo mCes Tbs Tb (SEQ ID NO: 25), xi) mCbs Gbs Geo Teo Ges mCds mCds Ads Tds Tds Ads mCds Tds mCds mCds mCeo Teo Tes Tbs mCb (SEQ ID NO: 26), xii) Gbs Abs Aeo mCeo Tes Gds Ads Tds Gds mCds mCds Tds mCds Tds Ads mCeo mCeo Tes mCbs mCb (SEQ ID NO: 27), xiii) Abs mCbs Teo Geo Aes Ads mCds Tds Gds Ads Tds Gds mCds mCds Tds mCeo Teo Aes mCbs mCb (SEQ ID NO: 28), xiv) Tbs Abs mCeo Aeo Tes Gds Gds mCds mCds Ads Gds Ads Ads Ads mCds mCeo Aeo mCes Tbs Tb (SEQ ID NO: 29), xv) Abs Abs Geo mCeo mCes Ads Ads Gds mCds mCds mCds Ads Ads Ads Ads mCds Aeo mCeo Tes Abs Ab (SEQ ID NO: 30), xvi) Tbs mCbs mCeo Aeo Aes Ads Gds Gds Ads Gds mCds Ads mCds mCds Ads Aeo mCeo mCes Abs Ab (SEQ ID NO: 31), xvii) Gls mClo Als Geo Tes Tds mCds Tds Ads Tds mCds mCds mCds Ads mCds Teo mCes Alo Tls mCl (SEQ ID NO: 32), xviii) mCls mClo Gls Geo Tes Gds mCds mCds Ads Tds Tds Ads mCds Tds mCds mCeo mCes Tlo Tls Tl (SEQ ID NO: 35), xix) Tls Tlo Gls mCeo Aes Gds Ads Tds Ads Ads Ads Ads mCds mCds Ads Tds mCeo mCes mClo Als mCl (SEQ ID NO: 36), xx) Als Glo Tls Geo mCes mCds Ads Gds Ads mCds mCds mCds Tds Tds Tds mCeo Aes Tlo Tls Al (SEQ ID NO: 37), xxi) mCls mClo Als Aeo Ges Tds Gds mCds mCds Ads Gds Ads mCds mCds mCds Teo Tes Tlo mCls Al (SEQ ID NO: 38), xxii) Gls mClo Als Geo Aes Tds Ads Ads Ads Ads mCds mCds Ads Tds mCds mCds mCeo Aes mClo Tls Tl (SEQ ID NO: 39), xxiii) mCls Glo Gls Teo Ges mCds mCds Ads Tds Tds Ads mCds Tds mCds mCds mCeo Tes Tlo Tls mCl (SEQ ID NO: 40), xxiv) Gls Alo Als mCeo Tes Gds Ads Tds Gds mCds mCds Tds mCds Tds Ads mCeo mCes Tlo mCls mCl (SEQ ID NO: 41), xxv) Als mClo Tls Geo Aes Ads mCds Tds Gds Ads Tds Gds mCds mCds Tds mCeo Tes Alo mCls mCl (SEQ ID NO: 42), xxvi) Tls Alo mCls Aeo Tes Gds Gds mCds mCds Ads Gds Ads Ads Ads mCds mCeo Aes mClo Tls Tl (SEQ ID NO: 43), xxvii) Als Alo Gls mCeo mCes Ads Ads Gds mCds mCds mCds Ads Ads Ads Ads mCds Aeo mCes Tlo Als Al (SEQ ID NO: 44), xxviii) Tls mClo mCls Aeo Aes Ads Gds Gds Ads Gds mCds Ads mCds mCds Ads Aeo mCes mClo Als Al (SEQ ID NO: 45), in A series adenine, mC is 5-methylcytosine, G series guanine, T series thymine, e is 2'-MOE modified ribose, d series 2'-deoxyribose, b-series BNA, L series LNA, o is a phosphodiester internucleoside linkage, and S is a phosphorothioate internucleoside linkage. An oligonucleotide comprising the following structural formula:

. An oligonucleotide comprising the following structural formula:

. An oligonucleotide comprising the following structural formula:

. An oligonucleotide comprising the following structural formula:

. An oligonucleotide conjugate comprising the oligonucleotide according to any one of the preceding claims. A pharmaceutical composition comprising the oligonucleotide according to any one of claims 1 to 18 or the oligonucleotide conjugate according to claim 19, and a pharmaceutically acceptable excipient. A method for reducing the expression of α-synuclein in mammalian cells, which comprises making the cells with the oligonucleotide as claimed in any one of items 1 to 18, the oligonucleotide conjugate as claimed in item 19, Or contact with the pharmaceutical composition according to claim 20, thereby reducing the expression of α-synuclein in the cells. The method according to claim 21, wherein the cells are cells in the central nervous system, optionally cells in the human brain. A method for treating a synucleinopathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an oligonucleotide according to any one of claims 1 to 18, an oligonucleotide according to claim 19 Nucleotide conjugates, or the pharmaceutical composition according to claim 20. The method according to any one of claims 21 to 23, wherein the oligonucleotide reduces the amount of SNCA mRNA by at least 25, 50 in murine primary cortical neurons engineered to express human α-synuclein , 75 or 80%. The method of claim 23 or 24, wherein the oligonucleotide is injected intrathecally or intracranially into the individual. A use of an oligonucleotide as claimed in any one of claims 1 to 18 or an oligonucleotide conjugate as claimed in claim 19 for the manufacture of a treatment in a method according to any one of claims 23 to 25 There is an agent for a synucleinopathy in a subject in need thereof. The oligonucleotide of any one of claims 1 to 18, the oligonucleotide conjugate of claim 19, or the pharmaceutical composition of claim 20, which is used in any of claims 23 to 25 In one method is treating a synucleinopathy in an individual in need thereof. The method, use, oligonucleotide used, oligonucleotide conjugate used, or pharmaceutical composition used according to any one of claims 23 to 27, wherein the synucleinopathy is Parkinson's disease (Parkinson's disease), Lewy body dementia, Alzheimer's disease or multiple system atrophy.

Images