KR101044339B1 - 생체적합성 가교된 겔 - Google Patents
생체적합성 가교된 겔 Download PDFInfo
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- KR101044339B1 KR101044339B1 KR1020067015505A KR20067015505A KR101044339B1 KR 101044339 B1 KR101044339 B1 KR 101044339B1 KR 1020067015505 A KR1020067015505 A KR 1020067015505A KR 20067015505 A KR20067015505 A KR 20067015505A KR 101044339 B1 KR101044339 B1 KR 101044339B1
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- crosslinking
- gel
- polymer
- polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/245—Differential crosslinking of one polymer with one crosslinking type, e.g. surface crosslinking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
가교제를 첨가함으로써 용액 중에서 1종 이상의 생체적합성 고분자의 가교를 개시하는 단계,
상기 고분자를 가교하는 단계,
용액 중의 고분자 총 농도를 감소시키기 위하여 반응 혼합물을 희석하면서, 용액중의 500,000 Da보다 큰 분자량의 고분자를 더 첨가하고 가교하는 단계, 및
겔 타입 | F (N/mm2) σ=0.15N/mm2 |
I | 3.56 |
II | 5.86 |
III | 7.40 |
IV | 6.12 |
Claims (12)
- 가교제를 첨가함으로써 용액 중에서 1종 이상의 생체적합성 고분자의 가교를 개시하는 단계,상기 고분자를 가교하는 단계,용액 중의 고분자 총 농도를 감소시키기 위하여 반응 혼합물을 희석하면서, 용액중의 500,000 Da보다 큰 분자량의 고분자를 더 첨가하고 가교하는 단계, 및상기 가교제를 제거함으로써 가교 반응을 종료하는 단계를 포함하는 생체적합성 (biocompatible) 가교된 겔을 제조하는 방법.
- 제1항에 있어서, 상기 가교를 개시하는 단계가 염기성 매체 중에서 이루어지는 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법
- 제1항에 있어서, 상기 가교를 개시하는 단계가 산성 매체 중에서 이루어지는 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제1항에 있어서, 상기 고분자를 더 첨가하는 단계 도중 가교제를 더 첨가하는 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제1항에 있어서, 상기 가교를 종료하는 단계가 투석에 의하여 이루어지는 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제1항에 있어서, 상기 고분자가 천연에서 유래한 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제6항에 있어서, 상기 천연에서 유래한 고분자는: 히알루론산(hyaluronic acid), 콘드로이틴 설페이트(chondroitine sulfate), 케라탄(keratan), 케라탄 설페이트, 헤파린, 헤파린 설페이트, 셀룰로오스 및 그 유도체, 알기네이트류(arginates), 잔탄(xanthane), 카라게닌(carraghenin), 단백질 또는 핵산으로 이루어진 군에서 선택되는 화합물인 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제6항에 있어서, 상기 천연에서 유래한 1종 이상의 고분자는 인체에 본래 존재하지 않는 고분자로서,상기 인체에 본래 존재하지 않는 고분자는, 셀룰로오스 및 그 유도체; 알기네이트류; 잔탄; 카라게닌; 또는 인체에 본래 존재하는 1종 이상의 고분자로 가교된 고분자로 이루어진 군에서 선택된 것이고,상기 인체에 본래 존재하는 1종 이상의 고분자는 히알루론산, 콘드로이틴 설페이트, 케라탄, 케라탄 설페이트, 헤파린, 헤파린 설페이트, 단백질 또는 핵산으로 이루어진 군에서 선택된 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제1항에 있어서, 상기 가교제는 에폭사이드류(epoxids), 에피할로히드린류(epihalohydrins) 및 디비닐설폰(divinylsulfone)으로 이루어진 화합물 군의 성분에서 선택되는 2작용기 또는 다작용기의(bi- or polyfunctional) 분자인 것을 특징으로 하는 생체적합성 가교된 겔을 제조하는 방법.
- 제1항 내지 제9항 중 어느 한 항에 따른 방법에 의하여 제조된 겔.
- 제10항에 있어서, 상기 겔은 1종 이상의 분산된 활성 성분을 포함하는 겔을 구성하는 것을 특징으로 하는 겔.
- 제10항에 있어서, 상기 겔은 생물학적 조직을 분리, 대체 또는 충전하거나 또는 상기 조직의 부피를 증가시키거나 또는 생물학적 유체를 보충 또는 대체하기 위하여 사용되는 겔.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0400987 | 2004-02-03 | ||
FR0400987A FR2865737B1 (fr) | 2004-02-03 | 2004-02-03 | Gel reticule biocompatible |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20070004611A KR20070004611A (ko) | 2007-01-09 |
KR101044339B1 true KR101044339B1 (ko) | 2011-06-29 |
Family
ID=34746373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067015505A KR101044339B1 (ko) | 2004-02-03 | 2005-01-31 | 생체적합성 가교된 겔 |
Country Status (15)
Country | Link |
---|---|
US (1) | US8052990B2 (ko) |
EP (1) | EP1711552B1 (ko) |
JP (1) | JP5105274B2 (ko) |
KR (1) | KR101044339B1 (ko) |
CN (1) | CN100582146C (ko) |
AT (1) | ATE489420T1 (ko) |
AU (1) | AU2005219595B2 (ko) |
BR (1) | BRPI0507294B8 (ko) |
CA (1) | CA2554597C (ko) |
DE (1) | DE602005024919D1 (ko) |
ES (1) | ES2354699T3 (ko) |
FR (1) | FR2865737B1 (ko) |
PL (1) | PL1711552T3 (ko) |
RU (1) | RU2377260C2 (ko) |
WO (1) | WO2005085329A1 (ko) |
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- 2005-01-31 AU AU2005219595A patent/AU2005219595B2/en active Active
- 2005-01-31 CN CN200580003963A patent/CN100582146C/zh active Active
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US20030148995A1 (en) | 2000-07-19 | 2003-08-07 | Estelle Piron | Polysaccharide crosslinking, hydrogel preparation, resulting polysaccharide(s) and hydrogel(s), uses thereof |
Also Published As
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PL1711552T3 (pl) | 2011-04-29 |
CN1918219A (zh) | 2007-02-21 |
US20070196426A1 (en) | 2007-08-23 |
BRPI0507294B1 (pt) | 2019-02-19 |
CA2554597A1 (fr) | 2005-09-15 |
FR2865737B1 (fr) | 2006-03-31 |
RU2006127591A (ru) | 2008-02-10 |
JP5105274B2 (ja) | 2012-12-26 |
DE602005024919D1 (de) | 2011-01-05 |
BRPI0507294A (pt) | 2007-07-03 |
CA2554597C (fr) | 2012-04-24 |
CN100582146C (zh) | 2010-01-20 |
ES2354699T3 (es) | 2011-03-17 |
EP1711552B1 (fr) | 2010-11-24 |
EP1711552A1 (fr) | 2006-10-18 |
US8052990B2 (en) | 2011-11-08 |
AU2005219595A1 (en) | 2005-09-15 |
FR2865737A1 (fr) | 2005-08-05 |
JP2007520612A (ja) | 2007-07-26 |
RU2377260C2 (ru) | 2009-12-27 |
AU2005219595B2 (en) | 2010-07-29 |
BRPI0507294B8 (pt) | 2021-07-27 |
ATE489420T1 (de) | 2010-12-15 |
KR20070004611A (ko) | 2007-01-09 |
WO2005085329A1 (fr) | 2005-09-15 |
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