NL301033I2 - Larotrectinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, in het bijzonder larotrectinibsulfaat, met inbegrip van larotrectinibsulfaat monohydraat - Google Patents

Larotrectinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, in het bijzonder larotrectinibsulfaat, met inbegrip van larotrectinibsulfaat monohydraat Download PDF

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Publication number
NL301033I2
NL301033I2 NL301033C NL301033C NL301033I2 NL 301033 I2 NL301033 I2 NL 301033I2 NL 301033 C NL301033 C NL 301033C NL 301033 C NL301033 C NL 301033C NL 301033 I2 NL301033 I2 NL 301033I2
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larotrectinib
sulfate
optionally
pharmaceutically acceptable
acceptable salt
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NL301033C
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Dutch (nl)
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Array Biopharma Inc
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Publication of NL301033I2 publication Critical patent/NL301033I2/nl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
NL301033C 2008-10-22 2020-03-10 Larotrectinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, in het bijzonder larotrectinibsulfaat, met inbegrip van larotrectinibsulfaat monohydraat NL301033I2 (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10761608P 2008-10-22 2008-10-22
EP13197815.7A EP2725028B1 (en) 2008-10-22 2009-10-21 Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors
EP09740245.7A EP2350071B1 (en) 2008-10-22 2009-10-21 SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS
PCT/US2009/061519 WO2010048314A1 (en) 2008-10-22 2009-10-21 SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
NL301033I2 true NL301033I2 (nl) 2020-04-15

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NL301033C NL301033I2 (nl) 2008-10-22 2020-03-10 Larotrectinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, in het bijzonder larotrectinibsulfaat, met inbegrip van larotrectinibsulfaat monohydraat

Country Status (38)

Country Link
US (11) US8513263B2 (enrdf_load_stackoverflow)
EP (4) EP2350071B1 (enrdf_load_stackoverflow)
JP (5) JP5600111B2 (enrdf_load_stackoverflow)
KR (5) KR101634833B1 (enrdf_load_stackoverflow)
CN (2) CN103509017B (enrdf_load_stackoverflow)
AR (2) AR074052A1 (enrdf_load_stackoverflow)
AU (1) AU2009308465B2 (enrdf_load_stackoverflow)
BR (1) BRPI0919873B8 (enrdf_load_stackoverflow)
CA (1) CA2741313C (enrdf_load_stackoverflow)
CL (1) CL2011000880A1 (enrdf_load_stackoverflow)
CO (1) CO6440551A2 (enrdf_load_stackoverflow)
CR (1) CR20110261A (enrdf_load_stackoverflow)
CY (4) CY1118199T1 (enrdf_load_stackoverflow)
DK (4) DK3372605T3 (enrdf_load_stackoverflow)
ES (4) ES2588504T3 (enrdf_load_stackoverflow)
HR (3) HRP20140309T1 (enrdf_load_stackoverflow)
HU (4) HUE037716T2 (enrdf_load_stackoverflow)
IL (3) IL212341A0 (enrdf_load_stackoverflow)
LT (4) LT2725028T (enrdf_load_stackoverflow)
LU (1) LUC00150I2 (enrdf_load_stackoverflow)
ME (1) ME03010B (enrdf_load_stackoverflow)
MX (1) MX2011004204A (enrdf_load_stackoverflow)
MY (1) MY169791A (enrdf_load_stackoverflow)
NL (1) NL301033I2 (enrdf_load_stackoverflow)
NO (2) NO3106463T3 (enrdf_load_stackoverflow)
NZ (1) NZ592809A (enrdf_load_stackoverflow)
PL (4) PL3372605T3 (enrdf_load_stackoverflow)
PT (4) PT2350071E (enrdf_load_stackoverflow)
RS (3) RS53247B (enrdf_load_stackoverflow)
RU (1) RU2018131134A (enrdf_load_stackoverflow)
SG (3) SG10201914059WA (enrdf_load_stackoverflow)
SI (4) SI2350071T1 (enrdf_load_stackoverflow)
SM (2) SMT201800244T1 (enrdf_load_stackoverflow)
TR (1) TR201807039T4 (enrdf_load_stackoverflow)
TW (4) TWI670272B (enrdf_load_stackoverflow)
UA (1) UA106054C2 (enrdf_load_stackoverflow)
UY (1) UY32192A (enrdf_load_stackoverflow)
WO (1) WO2010048314A1 (enrdf_load_stackoverflow)

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