JP7559059B2 - 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 - Google Patents

免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 Download PDF

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JP7559059B2
JP7559059B2 JP2022520000A JP2022520000A JP7559059B2 JP 7559059 B2 JP7559059 B2 JP 7559059B2 JP 2022520000 A JP2022520000 A JP 2022520000A JP 2022520000 A JP2022520000 A JP 2022520000A JP 7559059 B2 JP7559059 B2 JP 7559059B2
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cancer
methyl
compound
amino
pyrido
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JP2022549375A5 (enExample
JP2022549375A (ja
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リィ，ジンウェイ
ウー，リアンシン
ヤオ，ウェンチン
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022520000A 2019-09-30 2020-09-29 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 Active JP7559059B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
US62/908,317 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Publications (3)

Publication Number Publication Date
JP2022549375A JP2022549375A (ja) 2022-11-24
JP2022549375A5 JP2022549375A5 (enExample) 2023-10-05
JP7559059B2 true JP7559059B2 (ja) 2024-10-01

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JP2022520000A Active JP7559059B2 (ja) 2019-09-30 2020-09-29 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物

Country Status (19)

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US (2) US11401279B2 (enExample)
EP (1) EP4037773A1 (enExample)
JP (1) JP7559059B2 (enExample)
KR (1) KR20220075382A (enExample)
CN (1) CN115175734B (enExample)
AR (1) AR120109A1 (enExample)
AU (1) AU2020357514A1 (enExample)
BR (1) BR112022005826A2 (enExample)
CA (1) CA3155852A1 (enExample)
CL (1) CL2022000787A1 (enExample)
CO (1) CO2022005378A2 (enExample)
CR (1) CR20220190A (enExample)
EC (1) ECSP22034236A (enExample)
IL (1) IL291471B2 (enExample)
MX (1) MX2022003578A (enExample)
PE (1) PE20221038A1 (enExample)
PH (1) PH12022550754A1 (enExample)
TW (1) TWI879811B (enExample)
WO (1) WO2021067217A1 (enExample)

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WO2017205464A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
HUE060256T2 (hu) 2016-06-20 2023-02-28 Incyte Corp Heterociklusos vegyületek mint immunmodulátorok
EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2018044783A1 (en) 2016-08-29 2018-03-08 Incyte Corporation Heterocyclic compounds as immunomodulators
JP7101678B2 (ja) 2016-12-22 2022-07-15 インサイト・コーポレイション 免疫調節剤としての複素環式化合物
ES2874756T3 (es) 2016-12-22 2021-11-05 Incyte Corp Derivados de triazolo[1,5-A]piridina como inmunomoduladores
WO2018119221A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Pyridine derivatives as immunomodulators
US20180179202A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
TWI877770B (zh) 2018-02-27 2025-03-21 美商英塞特公司 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
SMT202500157T1 (it) 2018-03-30 2025-05-12 Incyte Corp Composti eterociclici come immunomodulatori
HUE061503T2 (hu) 2018-05-11 2023-07-28 Incyte Corp Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok
EP3810610A1 (en) 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
WO2020010197A1 (en) 2018-07-05 2020-01-09 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
UA130430C2 (uk) 2019-05-31 2026-02-18 Янссен Фармацевтика Нв НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB
JP7665593B2 (ja) 2019-08-09 2025-04-21 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
PE20221038A1 (es) 2019-09-30 2022-06-17 Incyte Corp Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores
CA3160131A1 (en) 2019-11-11 2021-05-20 Incyte Corporation Salts and crystalline forms of a pd-1/pd-l1 inhibitor
CA3182595A1 (en) 2020-06-17 2021-12-23 Mingming Zhang Immunosuppressant, and preparation method therefor and use thereof
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
CR20230230A (es) 2020-11-06 2023-07-27 Incyte Corp Proceso para hacer un inhibidor de pd-1/pdl1 y sales y formas cristalinas del mismo
WO2023169373A1 (zh) * 2022-03-07 2023-09-14 上海和誉生物医药科技有限公司 一种全对称联苯基衍生物及其制备方法和应用
CN117384088A (zh) * 2023-09-27 2024-01-12 上海凌凯医药科技有限公司 一种3-硝基吡啶甲腈类化合物以及3-氨基-吡啶甲酰胺类化合物的制备方法
TW202523304A (zh) 2023-12-06 2025-06-16 美商英塞特公司 包含ｄｇｋ抑制劑及ｐｄ—１／ｐｄ—ｌ１抑制劑之組合療法
CN120204228B (zh) * 2025-04-17 2026-01-30 重庆医科大学附属第一医院 化合物或其盐在制备癌症治疗药物中的用途

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