JP4190579B2 - 非分裂細胞への核酸運搬のためのベクターおよび使用方法 - Google Patents
非分裂細胞への核酸運搬のためのベクターおよび使用方法 Download PDFInfo
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- JP4190579B2 JP4190579B2 JP51431997A JP51431997A JP4190579B2 JP 4190579 B2 JP4190579 B2 JP 4190579B2 JP 51431997 A JP51431997 A JP 51431997A JP 51431997 A JP51431997 A JP 51431997A JP 4190579 B2 JP4190579 B2 JP 4190579B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16061—Methods of inactivation or attenuation
- C12N2740/16062—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/540,259 | 1995-10-06 | ||
| US08/540,259 US6013516A (en) | 1995-10-06 | 1995-10-06 | Vector and method of use for nucleic acid delivery to non-dividing cells |
| PCT/US1996/015406 WO1997012622A1 (en) | 1995-10-06 | 1996-09-26 | Vector and method of use for nucleic acid delivery to non-dividing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11512615A JPH11512615A (ja) | 1999-11-02 |
| JPH11512615A5 JPH11512615A5 (enExample) | 2004-09-30 |
| JP4190579B2 true JP4190579B2 (ja) | 2008-12-03 |
Family
ID=24154683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51431997A Expired - Lifetime JP4190579B2 (ja) | 1995-10-06 | 1996-09-26 | 非分裂細胞への核酸運搬のためのベクターおよび使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6013516A (enExample) |
| EP (1) | EP0871459B1 (enExample) |
| JP (1) | JP4190579B2 (enExample) |
| AT (1) | ATE260981T1 (enExample) |
| AU (1) | AU720993B2 (enExample) |
| DE (1) | DE69631795T2 (enExample) |
| IL (1) | IL123833A0 (enExample) |
| WO (1) | WO1997012622A1 (enExample) |
| ZA (1) | ZA968382B (enExample) |
Families Citing this family (803)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| PT904392E (pt) * | 1996-10-17 | 2001-06-29 | Oxford Biomedica Ltd | Vectores retrovirais |
| US7198784B2 (en) * | 1996-10-17 | 2007-04-03 | Oxford Biomedica (Uk) Limited | Retroviral vectors |
| US20070213290A1 (en) * | 1996-10-17 | 2007-09-13 | Kingsman Alan J | Neurite regeneration |
| WO1999032646A1 (en) * | 1997-12-22 | 1999-07-01 | Oxford Biomedica (Uk) Limited | Equine infectious anaemia virus (eiav) based |
| JP2001513643A (ja) * | 1997-03-06 | 2001-09-04 | ウーベルラ、クラウス | レンチウイルスをベースとするベクター及びベクター系 |
| CN1247788C (zh) * | 1997-05-13 | 2006-03-29 | 北卡罗来纳-查佩尔山大学 | 基于慢病毒的基因转移载体 |
| EP1003894A2 (en) * | 1997-07-18 | 2000-05-31 | Chiron Corporation | Lentiviral vectors |
| ATE298371T1 (de) | 1997-09-24 | 2005-07-15 | Univ California | Nicht-primaten lentivirale vektoren und verpackungssysteme |
| DE69836092T2 (de) * | 1997-10-24 | 2007-05-10 | Invitrogen Corp., Carlsbad | Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen |
| ES2245052T3 (es) * | 1997-12-01 | 2005-12-16 | Fang Fang | Anticuerpos de recombinacion multivalentes destinados para el tratamiento de infecciones debidas al rinovirus humano (hrv). |
| JP2002508338A (ja) * | 1997-12-12 | 2002-03-19 | ナルディニ,ルイジ | レンチウィルスベクターの治療使用 |
| US5994136A (en) * | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| US6451304B1 (en) * | 1998-03-09 | 2002-09-17 | The Regents Of The University Of California | Method for retrovirus vector production by separated gag and pol expression |
| US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| AU2003271326B2 (en) * | 1998-04-24 | 2007-06-28 | Centre National De La Recherche Scientifique | Use of triplex structure DNA sequences for transferring nucleotide sequences |
| AU2007216712B2 (en) * | 1998-04-24 | 2010-05-27 | Centre National De La Recherche Scientifique | Use of Triplex Structure DNA Sequences for Transferring Nucleotide Sequences |
| FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
| ES2291025T3 (es) | 1998-05-13 | 2008-02-16 | Genetix Pharmaceuticals Inc. | Celulas lentivirales de empaquetamiento. |
| US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| US6790657B1 (en) * | 1999-01-07 | 2004-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Lentivirus vector system |
| US6303116B1 (en) * | 1999-02-02 | 2001-10-16 | Thomas Jefferson University | Genetically engineered retroviral vector particles capable of infecting non-dividing cells |
| ATE368122T1 (de) * | 1999-04-29 | 2007-08-15 | Cell Genesys Inc | Verfahren und mittel für die herstellung von sicheren rekombinanten lentiviralen vektoren mit hohem titer |
| EP1188835A4 (en) * | 1999-06-22 | 2004-07-07 | Dnavec Research Inc | A VECTOR FOR THE EXPRESSION OF TWO FOREIGN GENES |
| ES2337429T3 (es) | 1999-10-11 | 2010-04-23 | Institut Pasteur | Vectores lentivirales para la preparacion de composiciones inmunoterapeuticas. |
| HK1050210B (en) | 1999-10-12 | 2007-08-24 | Institut Pasteur | Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna |
| CA2388301C (en) | 1999-10-22 | 2011-01-04 | Aventis Pasteur Limited | Modified gp100 and uses thereof |
| EP1103615A1 (en) * | 1999-11-25 | 2001-05-30 | Universite De Geneve | Vectors capable of immortalizing non-dividing cells and cells immortalized with said vectors |
| EP1852511B1 (en) * | 1999-12-14 | 2010-02-17 | Novartis AG | Bovine immunodeficiency virus (biv) based vectors |
| US6864085B2 (en) * | 1999-12-14 | 2005-03-08 | Novartis Ag | Bovine immunodeficiency virus (BIV) based vectors |
| CN102151337B (zh) | 2000-03-13 | 2014-03-12 | 恩根尼公司 | 调节消化道蛋白表达的组合物和方法 |
| AU2001249389A1 (en) * | 2000-03-22 | 2001-10-03 | The Children's Hospital Of Philadelphia | Modified blood clotting factors and methods of use |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
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| EP1301214A2 (en) * | 2000-05-26 | 2003-04-16 | Chiron Corporation | Methods of transducing neural cells using lentivirus vectors |
| US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| US6852510B2 (en) | 2000-07-03 | 2005-02-08 | Gala Design Inc | Host cells containing multiple integrating vectors |
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| US20030170642A1 (en) * | 2001-03-12 | 2003-09-11 | Irm, Llc | Identification of cellular targets for biologically active molecules |
| WO2002072789A2 (en) * | 2001-03-12 | 2002-09-19 | Irm, Llc. | Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters |
| ATE541937T1 (de) * | 2001-04-06 | 2012-02-15 | Univ Chicago | Chemotherapeutische einleitung der egr-1-promoter-aktivität in gentherapie |
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| JP2004537539A (ja) | 2001-06-29 | 2004-12-16 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | ヒトグロビン遺伝子をコードするベクターとその異常ヘモグロビン血症の治療におけるその使用 |
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| WO1990002806A1 (en) * | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| CA2067778A1 (en) * | 1989-10-16 | 1991-04-17 | The Whitehead Institute For Biomedical Research | Non-infectious hiv-1 particles and uses therefor |
| WO1991019798A1 (en) * | 1990-06-20 | 1991-12-26 | Dana Farber Cancer Institute | Vectors containing hiv packaging sequences, packaging defective hiv vectors, and uses thereof |
| US5817491A (en) * | 1990-09-21 | 1998-10-06 | The Regents Of The University Of California | VSV G pseusdotyped retroviral vectors |
| US5747307A (en) * | 1992-02-28 | 1998-05-05 | Syngenix Limited | Mason-Pfizer Monkey Retroviral packaging defective vectors |
| JPH08500005A (ja) * | 1992-03-27 | 1996-01-09 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | 非感染性hiv粒子およびその用途 |
| JPH06261764A (ja) * | 1993-02-17 | 1994-09-20 | Wisconsin Alumni Res Found | 混合型ltr含有超複合型レトロウイルス及びその使用方法 |
| US5834256A (en) * | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| US5580766A (en) * | 1994-01-14 | 1996-12-03 | Alexion Pharmaceuticals, Inc. | Retroviral vector particles for transducing non-proliferating cells |
| JPH09510361A (ja) * | 1994-03-24 | 1997-10-21 | シンジェニックス・リミテッド | パッケージング欠陥性レンチウイルス |
| US5750396A (en) * | 1995-05-08 | 1998-05-12 | St. Judes Children's Research Hospital | Stable virus packaging cell lines |
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- 1995-10-06 US US08/540,259 patent/US6013516A/en not_active Expired - Lifetime
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- 1996-09-26 EP EP96933140A patent/EP0871459B1/en not_active Revoked
- 1996-09-26 AU AU71681/96A patent/AU720993B2/en not_active Expired
- 1996-10-04 ZA ZA968382A patent/ZA968382B/xx unknown
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| EP0871459A1 (en) | 1998-10-21 |
| EP0871459B1 (en) | 2004-03-03 |
| DE69631795T2 (de) | 2005-02-10 |
| US6013516A (en) | 2000-01-11 |
| AU720993B2 (en) | 2000-06-22 |
| EP0871459A4 (en) | 2001-09-05 |
| JPH11512615A (ja) | 1999-11-02 |
| DE69631795D1 (de) | 2004-04-08 |
| ZA968382B (en) | 1997-06-27 |
| WO1997012622A1 (en) | 1997-04-10 |
| ATE260981T1 (de) | 2004-03-15 |
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