PT2238170T - Anticorpos contra cd39 humano e seu uso para inibição da actividade de células t reguladoras - Google Patents
Anticorpos contra cd39 humano e seu uso para inibição da actividade de células t reguladorasInfo
- Publication number
- PT2238170T PT2238170T PT97052120T PT09705212T PT2238170T PT 2238170 T PT2238170 T PT 2238170T PT 97052120 T PT97052120 T PT 97052120T PT 09705212 T PT09705212 T PT 09705212T PT 2238170 T PT2238170 T PT 2238170T
- Authority
- PT
- Portugal
- Prior art keywords
- inhibiting
- antibodies against
- against human
- regulatory cells
- cells activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08300061 | 2008-01-31 | ||
EP08162683 | 2008-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2238170T true PT2238170T (pt) | 2017-02-21 |
Family
ID=40568778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97052120T PT2238170T (pt) | 2008-01-31 | 2009-01-30 | Anticorpos contra cd39 humano e seu uso para inibição da actividade de células t reguladoras |
Country Status (8)
Country | Link |
---|---|
US (3) | US20100303828A1 (pt) |
EP (2) | EP2238170B1 (pt) |
JP (2) | JP6018361B2 (pt) |
DK (2) | DK2238170T3 (pt) |
ES (2) | ES2618292T3 (pt) |
HU (1) | HUE032025T2 (pt) |
PT (1) | PT2238170T (pt) |
WO (1) | WO2009095478A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009095478A1 (en) | 2008-01-31 | 2009-08-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
US8865653B2 (en) * | 2010-04-22 | 2014-10-21 | Institut Gustave Roussy | Method of treatment for immunogenic treatment resistant cancer |
MX349057B (es) | 2010-11-30 | 2017-07-07 | Chugai Pharmaceutical Co Ltd | Agente terapeutico que induce citotoxicidad. |
US20130273062A1 (en) * | 2010-12-22 | 2013-10-17 | Orega Biotech | Antibodies against human cd39 and use thereof |
US11492383B2 (en) | 2011-06-24 | 2022-11-08 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
US10000572B2 (en) * | 2013-08-01 | 2018-06-19 | Université Catholique de Louvain | Method for inhibiting the immune suppressive function of human T regulatory cells by administering an anti-GARP monoclonal antibody |
RU2722788C2 (ru) | 2014-04-07 | 2020-06-03 | Чугаи Сейяку Кабусики Кайся | Иммуноактивирующая антигенсвязывающая молекула |
MX2016014434A (es) * | 2014-05-13 | 2017-02-23 | Chugai Pharmaceutical Co Ltd | Molecula de union a antigeno redirigida a celulas t para celulas que tienen funcion de inmunosupresion. |
WO2016073845A1 (en) * | 2014-11-07 | 2016-05-12 | Igenica Biotherapeutics, Inc. | Anti-cd39 antibodies and uses thereof |
JP6154415B2 (ja) * | 2015-03-20 | 2017-06-28 | 株式会社三共 | 遊技機 |
JP6154416B2 (ja) * | 2015-03-20 | 2017-06-28 | 株式会社三共 | 遊技機 |
JP6154417B2 (ja) * | 2015-03-20 | 2017-06-28 | 株式会社三共 | 遊技機 |
US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
EP3378488A4 (en) | 2015-11-18 | 2019-10-30 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR ENHANCING THE HUMORAL IMMUNE RESPONSE |
AU2016359790A1 (en) * | 2015-11-23 | 2018-06-21 | Innate Pharma | CD39 vascular isoform targeting agents |
EP3429692A1 (en) * | 2016-03-14 | 2019-01-23 | Innate Pharma | Anti-cd39 antibodies |
EP3452092B1 (en) | 2016-05-06 | 2020-08-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions for the treatment of chemoresistant acute myeloid leukemia (aml) |
SG11201810509PA (en) | 2016-06-20 | 2018-12-28 | Kymab Ltd | Anti-pd-l1 antibodies |
WO2018065552A1 (en) | 2016-10-06 | 2018-04-12 | Innate Pharma | Anti-cd39 antibodies |
CN110168089A (zh) * | 2016-10-07 | 2019-08-23 | 瑟卡尔纳制药有限公司 | 抑制cd39表达的免疫抑制恢复寡核苷酸 |
CN110072891A (zh) * | 2016-12-13 | 2019-07-30 | 安斯泰来制药株式会社 | 抗人cd73抗体 |
JP2020501589A (ja) * | 2016-12-23 | 2020-01-23 | ウイルツ・バイオロジクス・リミテッド | がんの治療 |
EP3596124A1 (en) * | 2017-03-16 | 2020-01-22 | Innate Pharma | Compositions and methods for treating cancer |
EP3661966A4 (en) | 2017-07-31 | 2021-07-21 | Tizona Therapeutics | ANTI-CD39 ANTIBODIES, COMPOSITIONS INCLUDING ANTI-CD39 ANTIBODIES AND METHODS OF USE OF ANTI-CD39 ANTIBODIES |
AU2018346447A1 (en) * | 2017-10-06 | 2020-03-19 | Innate Pharma | Restoration of T cell activity via the CD39/CD73 axis |
WO2019096900A1 (en) | 2017-11-15 | 2019-05-23 | Innate Pharma | Potentiating the effect of atp release |
MX2020005583A (es) | 2017-12-01 | 2020-11-25 | Abbvie Inc | Agonista del receptor de glucocorticoides e inmunoconjugados de este. |
CN113754768B (zh) * | 2018-03-14 | 2023-01-06 | 表面肿瘤学公司 | 结合cd39的抗体及其用途 |
KR20210031694A (ko) * | 2018-06-14 | 2021-03-22 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 엑토뉴클레오티다제 억제 및 항체-매개된 표적 사이토시스를 통한 t-세포 고갈을 예방 또는 역전시키는 조성물 및 방법 |
CA3099893A1 (en) | 2018-06-18 | 2019-12-26 | Innate Pharma | Compositions and methods for treating cancer |
WO2020115262A1 (en) | 2018-12-07 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes |
CN112714768A (zh) * | 2019-08-27 | 2021-04-27 | 科望(苏州)生物医药科技有限公司 | 新型抗cd39抗体 |
WO2021055329A1 (en) | 2019-09-16 | 2021-03-25 | Surface Oncology, Inc. | Anti-cd39 antibody compositions and methods |
CN110407941B (zh) * | 2019-09-25 | 2020-01-14 | 上海岸迈生物科技有限公司 | Cd39的高亲和力抗体及其用途 |
CA3174202A1 (en) * | 2020-04-03 | 2021-10-07 | Trishula Therapeutics, Inc. | Combination therapy involving anti-cd39 antibodies and adoptive cell therapy |
AU2022218137A1 (en) | 2021-02-03 | 2023-08-24 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
WO2023164872A1 (en) * | 2022-03-03 | 2023-09-07 | Arcus Biosciences, Inc. | Anti-cd39 antibodies and use thereof |
US20240034803A1 (en) * | 2022-03-03 | 2024-02-01 | Arcus Biosciences, Inc. | Anti-cd39 antibodies and use thereof |
WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
WO2024030956A2 (en) | 2022-08-03 | 2024-02-08 | Mozart Therapeutics, Inc. | Cd39-specific binding agents and methods of using the same |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
EP0247091B1 (en) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
WO1994019478A1 (en) | 1993-02-22 | 1994-09-01 | The Rockefeller University | Production of high titer helper-free retroviruses by transient transfection |
FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
WO1996002576A1 (fr) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre l'interleukine-8 humaine |
ATE186745T1 (de) | 1995-01-18 | 1999-12-15 | Roche Diagnostics Gmbh | Antikörper gegen cd30, die proteolytische spaltung und abgabe des membrangebundenen cd30 antigens verhindern |
IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
WO1996032471A2 (en) | 1995-04-10 | 1996-10-17 | Universite De Sherbrooke | Atp-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology |
AU690474B2 (en) | 1995-09-11 | 1998-04-23 | Kyowa Hakko Kirin Co., Ltd. | Antibody againts alpha-chain of human interleukin 5 receptor |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
JP2001522241A (ja) | 1997-04-10 | 2001-11-13 | ロイヤル ネザーランズ アカデミー オブ アーツ アンド サイエンシズ | 診断方法および試薬 |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
WO2003052121A2 (en) | 2001-12-17 | 2003-06-26 | Beth Israel Deaconess Medical Center | Method of reducing angiogenesis |
DE60334453D1 (de) | 2002-05-30 | 2010-11-18 | Macrogenics Inc | Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten |
US20050037382A1 (en) * | 2003-04-08 | 2005-02-17 | Robson Simon C. | Methods and compositions for treating and preventing autoimmune disorders |
WO2006083289A2 (en) * | 2004-06-04 | 2006-08-10 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
US7556930B2 (en) * | 2005-04-18 | 2009-07-07 | Metabolex Inc. | CD39L3 and its role in diabetes |
WO2006111986A1 (en) * | 2005-04-19 | 2006-10-26 | Fondazione Santa Lucia I.R.C.C.S. | Method for the detection and the isolation of immunosuppressive regulatory t cells and uses thereof |
DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
EP1907424B1 (en) | 2005-07-01 | 2015-07-29 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
PE20090481A1 (es) | 2007-07-16 | 2009-05-18 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso |
US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
WO2009095478A1 (en) | 2008-01-31 | 2009-08-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
RU2531758C2 (ru) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Моноклональные антитела для лечения опухолей |
US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
PL2376535T3 (pl) | 2008-12-09 | 2017-09-29 | F.Hoffmann-La Roche Ag | Przeciwciała ANTY-PD-L1 i ich zastosowanie do nasilania działania limfocytów T |
SI3279215T1 (sl) | 2009-11-24 | 2020-07-31 | Medimmune Limited | Usmerjena vezavna sredstva proti B7-H1 |
CA2782218C (en) | 2009-11-30 | 2018-07-31 | Janssen Biotech, Inc. | Antibody fc mutants with ablated effector functions |
US8865653B2 (en) | 2010-04-22 | 2014-10-21 | Institut Gustave Roussy | Method of treatment for immunogenic treatment resistant cancer |
AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
US20130273062A1 (en) | 2010-12-22 | 2013-10-17 | Orega Biotech | Antibodies against human cd39 and use thereof |
LT2654780T (lt) | 2010-12-23 | 2017-03-27 | Janssen Biotech, Inc. | Aktyvūs proteazei atsparūs antikūnai - fc mutantai |
KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들 |
LT3221363T (lt) | 2014-11-21 | 2020-08-10 | Bristol-Myers Squibb Company | Antikūnai prieš cd73 ir jų panaudojimas |
AU2016359790A1 (en) | 2015-11-23 | 2018-06-21 | Innate Pharma | CD39 vascular isoform targeting agents |
WO2018065552A1 (en) | 2016-10-06 | 2018-04-12 | Innate Pharma | Anti-cd39 antibodies |
EP3596124A1 (en) | 2017-03-16 | 2020-01-22 | Innate Pharma | Compositions and methods for treating cancer |
EP3661966A4 (en) | 2017-07-31 | 2021-07-21 | Tizona Therapeutics | ANTI-CD39 ANTIBODIES, COMPOSITIONS INCLUDING ANTI-CD39 ANTIBODIES AND METHODS OF USE OF ANTI-CD39 ANTIBODIES |
AU2018346447A1 (en) | 2017-10-06 | 2020-03-19 | Innate Pharma | Restoration of T cell activity via the CD39/CD73 axis |
WO2019096900A1 (en) | 2017-11-15 | 2019-05-23 | Innate Pharma | Potentiating the effect of atp release |
CA3099893A1 (en) | 2018-06-18 | 2019-12-26 | Innate Pharma | Compositions and methods for treating cancer |
-
2009
- 2009-01-30 WO PCT/EP2009/051078 patent/WO2009095478A1/en active Application Filing
- 2009-01-30 EP EP09705212.0A patent/EP2238170B1/en active Active
- 2009-01-30 PT PT97052120T patent/PT2238170T/pt unknown
- 2009-01-30 US US12/863,461 patent/US20100303828A1/en not_active Abandoned
- 2009-01-30 DK DK09705212.0T patent/DK2238170T3/en active
- 2009-01-30 EP EP16198909.0A patent/EP3153526B1/en active Active
- 2009-01-30 HU HUE09705212A patent/HUE032025T2/en unknown
- 2009-01-30 JP JP2010544716A patent/JP6018361B2/ja active Active
- 2009-01-30 DK DK16198909.0T patent/DK3153526T3/da active
- 2009-01-30 ES ES09705212.0T patent/ES2618292T3/es active Active
- 2009-01-30 ES ES16198909T patent/ES2848323T3/es active Active
-
2014
- 2014-10-24 JP JP2014217832A patent/JP6041842B2/ja active Active
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2015
- 2015-11-12 US US14/939,650 patent/US10662253B2/en active Active
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2020
- 2020-05-21 US US16/880,835 patent/US11685792B2/en active Active
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JP2015057405A (ja) | 2015-03-26 |
EP2238170A1 (en) | 2010-10-13 |
JP6041842B2 (ja) | 2016-12-14 |
JP6018361B2 (ja) | 2016-11-02 |
US20100303828A1 (en) | 2010-12-02 |
US10662253B2 (en) | 2020-05-26 |
ES2848323T3 (es) | 2021-08-06 |
US11685792B2 (en) | 2023-06-27 |
US20210032367A1 (en) | 2021-02-04 |
ES2618292T3 (es) | 2017-06-21 |
EP3153526B1 (en) | 2020-09-23 |
HUE032025T2 (en) | 2017-08-28 |
EP2238170B1 (en) | 2016-11-23 |
EP3153526A1 (en) | 2017-04-12 |
DK2238170T3 (en) | 2017-02-27 |
US20160137747A1 (en) | 2016-05-19 |
DK3153526T3 (da) | 2020-12-14 |
JP2011510953A (ja) | 2011-04-07 |
WO2009095478A1 (en) | 2009-08-06 |
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