AR125136A1 - Receptores de antígenos quiméricos dirigidos a claudina-3 y métodos para tratar el cáncer - Google Patents

Receptores de antígenos quiméricos dirigidos a claudina-3 y métodos para tratar el cáncer

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Publication number
AR125136A1
AR125136A1 ARP220100626A ARP220100626A AR125136A1 AR 125136 A1 AR125136 A1 AR 125136A1 AR P220100626 A ARP220100626 A AR P220100626A AR P220100626 A ARP220100626 A AR P220100626A AR 125136 A1 AR125136 A1 AR 125136A1
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AR
Argentina
Prior art keywords
seq
sequence
claudin
determining region
heavy chain
Prior art date
Application number
ARP220100626A
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English (en)
Inventor
Thomas Southgate
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Glaxosmithkline Ip Dev Ltd
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Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of AR125136A1 publication Critical patent/AR125136A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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Abstract

Se describen receptores de antígeno quimérico (CAR) que incluyen una proteína de unión a antígeno que se une a un epítopo discontinuo en la claudina-3 humana que comprende al menos N38 y E153 de SEQ ID Nº 13. También se describen en el presente documento los polinucleótidos que codifican la proteína de unión a antígeno, los CAR, las células efectoras inmunitarias que contienen los CAR, las composiciones farmacéuticas que contienen las células efectoras inmunitarias y los métodos para tratar el cáncer con las células efectoras inmunitarias. Reivindicación 1: Un receptor de antígeno quimérico que comprende un polipéptido caracterizado porque comprende: a) un dominio extracelular que comprende un dominio de unión a claudina-3 que comprende una región variable de cadena pesada (VH) que comprende una secuencia de región determinante de complementariedad de cadena pesada 1 (CDRH1) de la SEQ ID Nº 1; una secuencia de región determinante de complementariedad de cadena pesada 2 (CDRH2) de la SEQ ID Nº 2; una secuencia de región determinante de complementariedad de cadena pesada 3 (CDRH3) de la SEQ ID Nº 3; b) un dominio transmembranario, y c) uno o más dominios de señalización intracelular. Reivindicación 22: Una proteína de unión a claudina-3 caracterizada porque comprende una región variable de cadena pesada (VH) que comprende una secuencia de región determinante de complementariedad de cadena pesada 1 (CDRH1) de la SEQ ID Nº 1; una secuencia de región determinante de complementariedad de cadena pesada 2 (CDRH2) de la SEQ ID Nº 2; una secuencia de región determinante de complementariedad de cadena pesada 3 (CDRH3) de la SEQ ID Nº 3, y una región variable de cadena ligera (VL) que comprende una secuencia de región determinante de complementariedad de cadena ligera 1 (CDRL1) de la SEQ ID Nº 4; una secuencia de región determinante de complementariedad de cadena ligera 2 (CDRL2) de la SEQ ID Nº 5; una secuencia de región determinante de complementariedad de cadena ligera 3 (CDRL3) de la SEQ ID Nº 6, en donde la proteína de unión a claudina-3 se selecciona del grupo que consiste en: un anticuerpo monoclonal, un isotipo IgG1 humano, una Ig de camello, una Ig NAR, fragmentos Fab, fragmentos Fab’, fragmentos F(ab)’₂, fragmentos F(ab)’₃, Fv, fragmento variable de cadena única (scFv), bis scFv, (scFv)₂, minicuerpo, diacuerpo, triacuerpo, tetracuerpo, proteína Fv estabilizada por disulfuro (dsFv) y anticuerpo de dominio único (sdAb), y en donde la VL está situada en el N-terminal de la VH, o donde la VH está situada en el N-terminal de la VL, y/o donde la VL y la VH están directamente fusionadas entre sí mediante un enlace peptídico o unidas entre sí mediante un conector peptídico. Reivindicación 29: Una proteína de unión a la claudina-3 aislada que se une a un epítopo discontinuo en la claudina-3 humana que comprende al menos N38 y E153 de la SEQ ID Nº 13.
ARP220100626A 2021-03-19 2022-03-17 Receptores de antígenos quiméricos dirigidos a claudina-3 y métodos para tratar el cáncer AR125136A1 (es)

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US (1) US20230192842A1 (es)
EP (1) EP4308605A1 (es)
JP (1) JP2024513713A (es)
KR (1) KR20230160307A (es)
CN (1) CN117377691A (es)
AR (1) AR125136A1 (es)
BR (1) BR112023018987A2 (es)
CA (1) CA3212615A1 (es)
TW (1) TW202304960A (es)
WO (1) WO2022195535A1 (es)

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