AR125130A1 - Conjugados de amatoxina y anticuerpo específicos de linfocitos b - Google Patents
Conjugados de amatoxina y anticuerpo específicos de linfocitos bInfo
- Publication number
- AR125130A1 AR125130A1 ARP220100614A ARP220100614A AR125130A1 AR 125130 A1 AR125130 A1 AR 125130A1 AR P220100614 A ARP220100614 A AR P220100614A AR P220100614 A ARP220100614 A AR P220100614A AR 125130 A1 AR125130 A1 AR 125130A1
- Authority
- AR
- Argentina
- Prior art keywords
- binding
- antigen
- antibody
- seq
- target
- Prior art date
Links
- WVHGJJRMKGDTEC-WCIJHFMNSA-N 2-[(1R,4S,8R,10S,13S,16S,27R,34S)-34-[(2S)-butan-2-yl]-8,22-dihydroxy-13-[(2R,3S)-3-hydroxybutan-2-yl]-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide Chemical compound CC[C@H](C)[C@@H]1NC(=O)CNC(=O)[C@@H]2Cc3c([nH]c4cc(O)ccc34)[S@](=O)C[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H]([C@@H](C)[C@H](C)O)C(=O)N2 WVHGJJRMKGDTEC-WCIJHFMNSA-N 0.000 title abstract 4
- 231100000729 Amatoxin Toxicity 0.000 title abstract 4
- 108010014709 amatoxin Proteins 0.000 title abstract 4
- 210000003719 b-lymphocyte Anatomy 0.000 title abstract 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 abstract 11
- 239000000427 antigen Substances 0.000 abstract 8
- 102000036639 antigens Human genes 0.000 abstract 8
- 108091007433 antigens Proteins 0.000 abstract 8
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 abstract 7
- 239000012634 fragment Substances 0.000 abstract 5
- 102000048426 human CD37 Human genes 0.000 abstract 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 3
- 231100000765 toxin Toxicity 0.000 abstract 3
- 239000003053 toxin Substances 0.000 abstract 3
- 229950001237 lilotomab Drugs 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 abstract 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 229950002138 naratuximab Drugs 0.000 abstract 1
- 229950000121 otlertuzumab Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente solicitud se refiere a conjugados que comprenden una amatoxina, un resto de unión a diana en donde la diana es CD37, es decir, un resto de unión a CD37 y, opcionalmente, un enlazador que une dicha amatoxina y dicho resto de unión a CD37. La invención se refiere además a la síntesis de dichos conjugados. Además, la invención se refiere a una composición farmacéutica que comprende dicho conjugado para su uso en el tratamiento de enfermedades y/o neoplasias malignas asociadas a células inmunitarias, particularmente a células B y/o al linfoma. Reivindicación 1: Un conjugado que comprende (i) un resto de unión a diana, (ii) al menos una toxina y, (iii) opcionalmente, al menos un enlazador que conecta dicho resto de unión a diana con dicha al menos una toxina, en donde dicho resto de unión a diana se une a CD37 y en donde dicha al menos una toxina es una amatoxina. Reivindicación 2: Conjugado de acuerdo con la reivindicación 1, en donde dicho resto de unión a diana se selecciona del grupo que consiste en (i) un anticuerpo, preferentemente un anticuerpo monoclonal, (ii) un fragmento de unión a antígeno del mismo, preferentemente un dominio variable (Fv), un fragmento Fab o un fragmento F(ab)₂, (iii) un derivado de unión a antígeno del mismo, preferentemente un Fv monocatenario (scFv) y (iv) una proteína similar a anticuerpo, uniéndose cada uno a CD37, preferentemente a CD37 humano, preferentemente al dominio extracelular de CD37 humano, respectivamente. Reivindicación 3: Conjugado de acuerdo con la reivindicación 2, en donde dicho anticuerpo, o fragmento de unión a antígeno del mismo o derivado de unión a antígeno del mismo, es un anticuerpo murino, quimérico, humanizado o humano, o fragmento de unión a antígeno o derivado de unión a antígeno del mismo, respectivamente. Reivindicación 4: Conjugado de acuerdo con la reivindicación 2, en donde dicho anticuerpo se selecciona del grupo que consiste en Tetulomab (Lilotomab), Otlertuzumab (TRU-016) y Naratuximab, BI836826 o GEN3009. Reivindicación 5: Conjugado de acuerdo con la reivindicación 2, en donde dicho anticuerpo, o fragmento de unión a antígeno del mismo, o derivado de unión a antígeno del mismo, respectivamente, comprende las siguientes regiones determinantes de la complementariedad (CDR): CDRH1 de acuerdo con la SEQ ID Nº 1 (DYNMY), CDRH2 de acuerdo con la SEQ ID Nº 2 (YIDPYNGDTTYNQKFKG), CDRH3 de acuerdo con la SEQ ID Nº 3 (SPYGHYAMDY), CDRL1 de acuerdo con la SEQ ID Nº 4 (KASQDVSTAVD), CDRL2 de acuerdo con la SEQ ID Nº 5 (WASTRHT), CDRL3 de acuerdo con la SEQ ID Nº 6 (RQHYSTPFT), en donde dichas CDR están comprendidas en un armazón proteínico adecuado para que sean capaces de unirse a CD37, preferentemente a CD37 humano, preferentemente al dominio extracelular de CD37 humano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21163784 | 2021-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR125130A1 true AR125130A1 (es) | 2023-06-14 |
Family
ID=75111534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220100614A AR125130A1 (es) | 2021-03-19 | 2022-03-17 | Conjugados de amatoxina y anticuerpo específicos de linfocitos b |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220370632A1 (es) |
EP (1) | EP4308169A2 (es) |
JP (1) | JP2024512478A (es) |
KR (1) | KR20230159480A (es) |
CN (1) | CN117241832A (es) |
AR (1) | AR125130A1 (es) |
AU (1) | AU2022236461A1 (es) |
BR (1) | BR112023018189A2 (es) |
CA (1) | CA3208117A1 (es) |
CL (1) | CL2023002775A1 (es) |
CO (1) | CO2023012358A2 (es) |
IL (1) | IL304966A (es) |
WO (1) | WO2022194988A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230355792A1 (en) | 2022-04-07 | 2023-11-09 | Heidelberg Pharma Research Gmbh | Methods of improving the therapeutic index |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Immunoconjugates of anthracycline, their production and pharmaceutical preparations containing them |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
PT871490E (pt) | 1995-12-22 | 2003-07-31 | Bristol Myers Squibb Co | Ligantes de hidrazona ramificada |
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
SI2439273T1 (sl) | 2005-05-09 | 2019-05-31 | Ono Pharmaceutical Co., Ltd. | Človeška monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka z uporabo protiteles proti PD-1 samostojno ali v kombinaciji z ostalimi imunoterapevtiki |
KR101586617B1 (ko) | 2007-06-18 | 2016-01-20 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 pd-1에 대한 항체 |
DE202007018529U1 (de) | 2007-07-07 | 2008-12-04 | Chamalow S.A. | Implantierbarer Funkfrequenzdefibrillator R.F. |
WO2009101611A1 (en) | 2008-02-11 | 2009-08-20 | Curetech Ltd. | Monoclonal antibodies for tumor treatment |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
US9233173B2 (en) | 2009-04-08 | 2016-01-12 | Deutsches Krebsforschungszentrum | Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy |
US20100311116A1 (en) | 2009-06-04 | 2010-12-09 | Excellgene Sa | Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure |
EP2311397B1 (de) * | 2009-10-15 | 2012-05-30 | W+S Solutions GmbH | Drehmomentbegrenzer |
US20130088363A1 (en) * | 2011-10-06 | 2013-04-11 | Alexander Gonzalez | Telemetry Method and System for Well Logging |
JP2015501654A (ja) * | 2011-12-13 | 2015-01-19 | ノルディック ナノベクター アーエス | 治療用キメラ型抗cd37抗体hh1 |
US20150218220A1 (en) | 2012-09-12 | 2015-08-06 | Brian Alan MENDELSOHN | Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase |
EP2774624A1 (en) * | 2013-03-04 | 2014-09-10 | Heidelberg Pharma GmbH | Amatoxin derivatives |
CU24345B1 (es) | 2013-09-06 | 2018-05-08 | Aurigene Discovery Tech Ltd | Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores |
CN114395050A (zh) * | 2015-03-09 | 2022-04-26 | 海德堡医药有限责任公司 | 鹅膏毒素-抗体轭合物 |
EP3222292A1 (en) | 2016-03-03 | 2017-09-27 | Heidelberg Pharma GmbH | Amanitin conjugates |
MX2019007604A (es) | 2016-12-23 | 2019-08-16 | Heidelberg Pharma Res Gmbh | Novedoso conjugado de amanitina. |
CN110691790A (zh) | 2017-06-02 | 2020-01-14 | 勃林格殷格翰国际有限公司 | 抗癌联合治疗 |
US10961277B2 (en) | 2017-08-07 | 2021-03-30 | Heidelberg Pharma Research Gmbh | Method for synthesizing amanitins |
EP3958908A1 (en) * | 2019-04-24 | 2022-03-02 | Heidelberg Pharma Research GmbH | Amatoxin antibody-drug conjugates and uses thereof |
IL302034A (en) * | 2020-11-04 | 2023-06-01 | Heidelberg Pharma Res Gmbh | The composition includes a combination of an immune control inhibitor and a conjugated amatoxin antibody for use in cancer treatment |
-
2022
- 2022-03-17 JP JP2023557076A patent/JP2024512478A/ja active Pending
- 2022-03-17 WO PCT/EP2022/056932 patent/WO2022194988A2/en active Application Filing
- 2022-03-17 CA CA3208117A patent/CA3208117A1/en active Pending
- 2022-03-17 AU AU2022236461A patent/AU2022236461A1/en active Pending
- 2022-03-17 KR KR1020237035048A patent/KR20230159480A/ko unknown
- 2022-03-17 IL IL304966A patent/IL304966A/en unknown
- 2022-03-17 EP EP22712427.8A patent/EP4308169A2/en active Pending
- 2022-03-17 CN CN202280029470.3A patent/CN117241832A/zh active Pending
- 2022-03-17 AR ARP220100614A patent/AR125130A1/es unknown
- 2022-03-17 BR BR112023018189A patent/BR112023018189A2/pt unknown
- 2022-03-17 US US17/697,583 patent/US20220370632A1/en active Pending
-
2023
- 2023-09-19 CO CONC2023/0012358A patent/CO2023012358A2/es unknown
- 2023-09-19 CL CL2023002775A patent/CL2023002775A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20230159480A (ko) | 2023-11-21 |
CL2023002775A1 (es) | 2024-04-01 |
WO2022194988A2 (en) | 2022-09-22 |
BR112023018189A2 (pt) | 2023-10-24 |
EP4308169A2 (en) | 2024-01-24 |
AU2022236461A1 (en) | 2023-10-05 |
AU2022236461A9 (en) | 2024-02-22 |
JP2024512478A (ja) | 2024-03-19 |
US20220370632A1 (en) | 2022-11-24 |
IL304966A (en) | 2023-10-01 |
CN117241832A (zh) | 2023-12-15 |
CA3208117A1 (en) | 2022-09-22 |
WO2022194988A3 (en) | 2022-12-29 |
CO2023012358A2 (es) | 2024-01-15 |
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