JP2012017330A5

JP2012017330A5 -

Download PDF

Info

Publication number: JP2012017330A5
Authority: JP; Japan
Prior art keywords: dpp; inhibitor; composition; pharmaceutical composition; gpr119 agonist
Prior art date: 2011-08-05
Legal status : Withdrawn

Application number

JP2011172381A

Other languages

English (en)

Japanese (ja)

Other versions

JP2012017330A (ja

Filing date

2011-08-05

Publication date

2012-03-08

2011-08-05 Application filed filed Critical

2012-01-26 Publication of JP2012017330A publication Critical patent/JP2012017330A/ja

2012-03-08 Publication of JP2012017330A5 publication Critical patent/JP2012017330A5/ja

Status Withdrawn legal-status Critical Current

Links

108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 44
102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 44
239000003112 inhibitor Substances 0.000 claims 38
239000008194 pharmaceutical composition Substances 0.000 claims 30
239000000203 mixture Substances 0.000 claims 29
AJJISMLYIMQAKP-OAHLLOKOSA-N 5-[4-[(2r)-4-(3-fluoro-4-methylsulfonylphenoxy)butan-2-yl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole Chemical compound CC(C)C1=NOC(N2CCC(CC2)[C@H](C)CCOC=2C=C(F)C(=CC=2)S(C)(=O)=O)=N1 AJJISMLYIMQAKP-OAHLLOKOSA-N 0.000 claims 26
229940100607 GPR119 agonist Drugs 0.000 claims 26
102100020751 Dipeptidyl peptidase 2 Human genes 0.000 claims 8
101710087084 Dipeptidyl peptidase 2 Proteins 0.000 claims 8
101000996752 Homo sapiens Glucose-dependent insulinotropic receptor Proteins 0.000 claims 6
101000957724 Catostomus commersonii Corticoliberin-1 Proteins 0.000 claims 4
102100033839 Glucose-dependent insulinotropic receptor Human genes 0.000 claims 4
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
-1 3-hydroxyadamantan-1-yl Chemical group 0.000 claims 3
ZHUTVLURGLOKMO-ZETCQYMHSA-N (2s)-1-acetylpyrrolidine-2-carbonitrile Chemical compound CC(=O)N1CCC[C@H]1C#N ZHUTVLURGLOKMO-ZETCQYMHSA-N 0.000 claims 2
WEZFYBVBPAUJAL-UHFFFAOYSA-N 2-ethylpentanenitrile Chemical compound CCCC(CC)C#N WEZFYBVBPAUJAL-UHFFFAOYSA-N 0.000 claims 2
VFFZWMWTUSXDCB-ZDUSSCGKSA-N 6-[2-[[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile Chemical compound N1([C@@H](CCC1)C#N)C(=O)CNCCNC1=CC=C(C#N)C=N1 VFFZWMWTUSXDCB-ZDUSSCGKSA-N 0.000 claims 2
108091005471 CRHR1 Proteins 0.000 claims 2
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 2
102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 2
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 claims 2
241000124008 Mammalia Species 0.000 claims 2
230000001668 ameliorated effect Effects 0.000 claims 2
239000008280 blood Substances 0.000 claims 2
210000004369 blood Anatomy 0.000 claims 2
206010012601 diabetes mellitus Diseases 0.000 claims 2
125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 2
102000045598 human DPP4 Human genes 0.000 claims 2
102000056352 human GPR119 Human genes 0.000 claims 2
102000005962 receptors Human genes 0.000 claims 2
108020003175 receptors Proteins 0.000 claims 2
229960004937 saxagliptin Drugs 0.000 claims 2
QGJUIPDUBHWZPV-SGTAVMJGSA-N saxagliptin Chemical group C1C(C2)CC(C3)CC2(O)CC13[C@H](N)C(=O)N1[C@H](C#N)C[C@@H]2C[C@@H]21 QGJUIPDUBHWZPV-SGTAVMJGSA-N 0.000 claims 2
108010033693 saxagliptin Proteins 0.000 claims 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical group C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 claims 2

JP2011172381A 2005-01-10 2011-08-05 糖尿病および糖尿病に関連する状態の治療のため、ならびに血中ｇｌｐ−１レベルの増加によって改善される状態の治療のための併用療法 Withdrawn JP2012017330A (ja)