JP2007527914A5 - - Google Patents

Download PDF

Info

Publication number
JP2007527914A5
JP2007527914A5 JP2007502989A JP2007502989A JP2007527914A5 JP 2007527914 A5 JP2007527914 A5 JP 2007527914A5 JP 2007502989 A JP2007502989 A JP 2007502989A JP 2007502989 A JP2007502989 A JP 2007502989A JP 2007527914 A5 JP2007527914 A5 JP 2007527914A5
Authority
JP
Japan
Prior art keywords
patient
administering
inhibiting
human
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007502989A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007527914A (ja
Filing date
Publication date
Priority claimed from US10/992,303 external-priority patent/US20050197336A1/en
Application filed filed Critical
Publication of JP2007527914A publication Critical patent/JP2007527914A/ja
Publication of JP2007527914A5 publication Critical patent/JP2007527914A5/ja
Withdrawn legal-status Critical Current

Links

JP2007502989A 2004-03-08 2005-03-08 ヒストン脱アセチル化酵素の阻害剤 Withdrawn JP2007527914A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55164404P 2004-03-08 2004-03-08
US10/992,303 US20050197336A1 (en) 2004-03-08 2004-11-17 Inhibitors of histone deacetylase
PCT/US2005/007906 WO2005086898A2 (en) 2004-03-08 2005-03-08 Inhibitors of histone deacetylase

Publications (2)

Publication Number Publication Date
JP2007527914A JP2007527914A (ja) 2007-10-04
JP2007527914A5 true JP2007527914A5 (enExample) 2008-04-10

Family

ID=34915721

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007502989A Withdrawn JP2007527914A (ja) 2004-03-08 2005-03-08 ヒストン脱アセチル化酵素の阻害剤

Country Status (6)

Country Link
US (2) US20050197336A1 (enExample)
EP (1) EP1755601A4 (enExample)
JP (1) JP2007527914A (enExample)
AU (1) AU2005221134A1 (enExample)
CA (1) CA2558243A1 (enExample)
WO (1) WO2005086898A2 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446109B2 (en) 2002-03-13 2008-11-04 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
JP4725945B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
KR20040090979A (ko) 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. 히스톤 데아세틸레이즈의 신규한 억제제
US7592450B2 (en) * 2002-03-13 2009-09-22 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase
TW200526626A (en) * 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
US20050197336A1 (en) * 2004-03-08 2005-09-08 Miikana Therapeutics Corporation Inhibitors of histone deacetylase
PL1725528T3 (pl) 2004-03-11 2013-12-31 4Sc Ag Sulfonylopirole jako inhibitory HDAC
US7345043B2 (en) * 2004-04-01 2008-03-18 Miikana Therapeutics Inhibitors of histone deacetylase
EP1781639B1 (en) 2004-07-28 2012-01-25 Janssen Pharmaceutica NV Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
US7772245B2 (en) * 2005-02-14 2010-08-10 Miikana Therapeutics, Inc. Inhibitors of histone deacetylase
US20080161306A1 (en) * 2005-02-18 2008-07-03 Brian Sherer Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
EP1853586B1 (en) * 2005-02-18 2013-07-24 AstraZeneca AB Antibacterial piperidine derivatives
CN101171250A (zh) * 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 具有抗菌活性的氮杂环丁烷和吡咯的三环衍生物
EP1861393A2 (en) * 2005-03-04 2007-12-05 AstraZeneca AB Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
CA2599538C (en) 2005-03-15 2013-07-30 Nycomed Gmbh N-sulphonylpyrroles and their use as histone deacetylase inhibitors
CA2605272C (en) 2005-05-18 2013-12-10 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
ES2381962T3 (es) 2005-09-21 2012-06-04 4Sc Ag Nuevos sulfonilpirroles como inhibidores de las HDAC
AU2006298881A1 (en) 2005-09-21 2007-04-12 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
US7884105B2 (en) * 2005-10-27 2011-02-08 Janssen Pharmaceutica, N.V. Squaric acid derivatives as inhibitors of histone deacetylase
US7834011B2 (en) 2006-01-19 2010-11-16 Janssen Pharmaceutica N.V. Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase
CN101370789B (zh) * 2006-01-19 2012-05-30 詹森药业有限公司 作为组蛋白脱乙酰酶抑制剂的吡啶和嘧啶衍生物
WO2007082878A1 (en) * 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Aminophenyl derivatives as novel inhibitors of histone deacetylase
US7834025B2 (en) * 2006-01-19 2010-11-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
JP5247470B2 (ja) * 2006-01-19 2013-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
CN101370791B (zh) 2006-01-19 2012-05-02 詹森药业有限公司 作为组蛋白脱乙酰基酶抑制剂的吡啶和嘧啶衍生物
RU2008135979A (ru) 2006-02-07 2010-03-20 Астеллас Фарма Инк. (Jp) Соединения гидроксиакрилаимда
GB0603041D0 (en) * 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8017612B2 (en) 2006-04-18 2011-09-13 Japan Tobacco Inc. Piperazine compound and use thereof as a HCV polymerase inhibitor
CA2662937A1 (en) * 2006-09-11 2008-03-20 Curis, Inc. Multi-functional small molecules as anti-proliferative agents
CN101534831B (zh) * 2006-09-11 2013-07-17 柯瑞斯公司 包含锌结合基团的取代的酪氨酸抑制剂
DK2343286T3 (en) * 2006-10-28 2015-04-13 Methylgene Inc Dibenzo [b, f] [1,4] oxazepine derivatives as inhibitors of histone deacetylase
WO2008058287A1 (en) * 2006-11-10 2008-05-15 Syndax Pharmaceuticals, Inc. COMBINATION OF ERα+ LIGANDS AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER
WO2008065409A2 (en) * 2006-12-01 2008-06-05 Betagenon Ab Combination for use in the treatment of cancer, comprising tamoxifen or an aromatase inhibitor
US8399486B2 (en) 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
TW200906412A (en) * 2007-06-12 2009-02-16 Astrazeneca Ab Piperidine compounds and uses thereof
US20100298270A1 (en) * 2007-07-23 2010-11-25 Syndax Pharmaceuticals, Inc. Novel Compounds and Methods of Using Them
US20100267779A1 (en) * 2007-07-23 2010-10-21 Syndax Pharmaceuticals, Inc. Novel Compounds and Methods of Using Them
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
WO2009049018A1 (en) * 2007-10-10 2009-04-16 Syndax Pharmaceuticals, Inc. Novel compounds and methods of using them
US20090149511A1 (en) * 2007-10-30 2009-06-11 Syndax Pharmaceuticals, Inc. Administration of an Inhibitor of HDAC and an mTOR Inhibitor
EP2217588A4 (en) * 2007-11-02 2013-12-04 Methylgene Inc INHIBITORS OF HISTONE DEACETYLASE
WO2009067453A1 (en) * 2007-11-19 2009-05-28 Syndax Pharmaceuticals, Inc. Combinations of hdac inhibitors and proteasome inhibitors
WO2009089598A2 (en) * 2008-01-18 2009-07-23 Katholieke Universiteit Leuven Msmb-gene methylation based diagnosis, staging and prognosis of prostate cancer
CA2764387A1 (en) 2009-06-05 2010-12-09 Link Medicine Corporation Aminopyrrolidinone derivatives and uses thereof
US8394858B2 (en) * 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
US8546588B2 (en) 2010-02-26 2013-10-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
EP2575815A4 (en) 2010-06-04 2013-12-25 Albany Molecular Res Inc GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF
CN103169720B (zh) * 2011-12-21 2016-12-07 张雅珍 蒽环类抗生素及其可药用盐在治疗视网膜静脉阻塞中的用途
ITRM20120405A1 (it) * 2012-08-09 2014-02-10 C N C C S Scarl Collezione Naziona Le Dei Compost Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac
US10188756B2 (en) 2013-10-18 2019-01-29 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography
EA201792028A1 (ru) * 2015-03-13 2018-04-30 Форма Терапьютикс, Инк. Альфа-цинамидные соединения и композиции как ингибиторы hdac8
CN111484469B (zh) * 2020-05-14 2022-07-05 遵义医科大学 吡喃亚基丙二腈类光敏剂先导化合物合成方法及其应用
KR102514860B1 (ko) * 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물
WO2025085848A1 (en) * 2023-10-20 2025-04-24 Arrepath, Inc. Antibacterial compounds

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5700811A (en) * 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
EP0827742A1 (en) * 1996-09-04 1998-03-11 Vrije Universiteit Brussel Use of histone deacetylase inhibitors for treating fribosis or cirrhosis
US5925672A (en) * 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
US6124495A (en) * 1997-03-11 2000-09-26 Beacon Laboratories, Inc. Unsaturated oxyalkylene esters and uses thereof
EP1233958B1 (en) * 1999-11-23 2011-06-29 MethylGene Inc. Inhibitors of histone deacetylase
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
WO2002055017A2 (en) * 2000-11-21 2002-07-18 Wake Forest University Method of treating autoimmune diseases
US7193105B2 (en) * 2002-05-22 2007-03-20 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on trihalomethylcarbonyl compounds
US6706686B2 (en) * 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
CA2463552C (en) * 2001-10-16 2011-05-17 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases and cancer of the brain
SE520636C2 (sv) * 2001-11-12 2003-08-05 Stroemsholmen Ab Anordning vid en energiackumelerande kolv-cylinderdon
JP2005525345A (ja) * 2002-02-15 2005-08-25 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ Ｔｒｘ媒介性疾患を処置する方法
US20040077591A1 (en) * 2002-03-28 2004-04-22 The Brigham And Women's Hospital, Inc. Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease
US20030206946A1 (en) * 2002-04-26 2003-11-06 Yih-Lin Chung Methods for therapy of connective tissue disease
SE0202157D0 (sv) * 2002-07-09 2002-07-09 Biovitrum Ab Methods for identification of compounds modulating insulin resistance
US20070088045A1 (en) * 2002-11-12 2007-04-19 Hellberg Peggy E Histone deacetylase inhibitors for treating degenerative diseases of the eye
MXPA05004485A (es) * 2002-11-12 2005-11-23 Alcon Inc Inhibidores de la histona desacetilasa para el tratamiento de enfermedades y trastornos neovasculares o edematosos oculares.
AU2003291097A1 (en) * 2002-11-20 2004-06-15 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US20040140461A1 (en) * 2003-01-22 2004-07-22 Lappen Alan Rick Configurable fence and gate systems
JP2006520796A (ja) * 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
US20050197336A1 (en) * 2004-03-08 2005-09-08 Miikana Therapeutics Corporation Inhibitors of histone deacetylase
US7345043B2 (en) * 2004-04-01 2008-03-18 Miikana Therapeutics Inhibitors of histone deacetylase

Similar Documents

Publication Publication Date Title
JP2007527914A5 (enExample)
CL2007003472A1 (es) Sal fumarato de (alfa s,beta r)-6-bromo-alfa-[2-(dimetilamino)etil]-2-metoxi-alfa-1-naftalenil-beta-fenil-3-quinolinaetanol; proceso de preparacion; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamie
IL182020A0 (en) Pharmaceutical composition comprising diclofenac
BRPI0812738A2 (pt) Composto, sal farmceuticamente aceitável, composição farmacêutica, uso de um composto, e, método par ao tratamento de uma infecção viral em um humano
IL208982B (en) A preparation containing baclofen or a salt, derivative or delayed release formulation thereof for use in the treatment of Alzheimer's disease
BRPI0810390A2 (pt) Película, composição, e, métodos para administrar um material ativo, para melhorar a estabilidade de uma película e para manter a saúde sistêmica de um mamífero
ATE517619T1 (de) Stabilisierte pharmazeutische zusammensetzung mit fesoterodin
EP2152237A4 (en) NEW PHARMACEUTICAL COMPOSITION
CA3094580C (en) Oral formulations of cytidine analogs and methods of use thereof
IL183357A0 (en) Oral medicament for the modified release of at least one active principle, in multimicrocapsule form
NO20085420L (no) Farmasøytisk formulering med fenylefrin og preparater for absorpsjon i tykktarmen
CL2007002376A1 (es) Compuestos derivados de pirrol sustituido; proceso de preparacion; composicion farmaceutica; y uso en enfermedades bacterianas.
CL2012003012A1 (es) Composicion farmaceutica oral de liberacion prolongada que comprenden a) al menos un material de liberacion prolongada y b) hidromorfona o una sal y naloxona o una sal en una relacion 2:1 a 1:3; metodo de preparacion.
JP2011511805A5 (enExample)
IL212707A0 (en) Compounds, pharmaceutical composition and methods for use in treating metabolic disorders
FR2934156B1 (fr) Medicament appetissant a administration orale sous forme solide
BR112012003283A8 (pt) sal farmaceuticamente aceitável de um agente fotossensibilizante anfifílico, composição farmacêutica, produto, kit, uso de um sal farmaceuticamente aceitável de um agente fotossensibilizante anfifílico, e, método de introdução de uma molécula de medicamento no citosol de uma célula em um paciente.
IL212568A (en) Annotated 4,1-Diazepan, Pharmaceutical Preparations Containing Them and Their Uses in the Preparation of Medicines for the Treatment of Diseases or Disorders of Mammals
IL195528A (en) Pyridazine compound, methods of preparation, a pharmaceutical composition containing it, its use and intermediate material
IL204658A (en) Pharmaceutical preparation for topical use in the form of an opaque gel-gel containing diclofenac diethylammonium salt
IL195931A0 (en) Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and methods for its production
JP2007536277A5 (enExample)
EP2199402A4 (en) CYCLOASTRAGENOL MONOGLYCOSIDE, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF
BR112012003280A2 (pt) composição farmacêutica para administração oral, método para tratar uma doença, uso do composto, e, composto.
ATE505203T1 (de) Pharmazeutische kombination aus aliskiren und valsartan