CY1109260T1 - Μεθοδος αναγνωρισης των διεγερτικων εκκρισης glp-1 - Google Patents

Μεθοδος αναγνωρισης των διεγερτικων εκκρισης glp-1

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Publication number
CY1109260T1
CY1109260T1 CY20091100816T CY091100816T CY1109260T1 CY 1109260 T1 CY1109260 T1 CY 1109260T1 CY 20091100816 T CY20091100816 T CY 20091100816T CY 091100816 T CY091100816 T CY 091100816T CY 1109260 T1 CY1109260 T1 CY 1109260T1
Authority
CY
Cyprus
Prior art keywords
amount
glp
level
increases
dpp
Prior art date
Application number
CY20091100816T
Other languages
English (en)
Inventor
Zhi-Liang Chu
James N Leonard
Hussien A Al-Shamma
Robert M Jones
Original Assignee
Arena Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36570727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109260(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arena Pharmaceuticals, Inc. filed Critical Arena Pharmaceuticals, Inc.
Publication of CY1109260T1 publication Critical patent/CY1109260T1/el

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

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Abstract

Η παρούσα εφεύρεση αφορά το συνδυασμό μιας ποσότητας ενός αγωνιστή GPR119 με μια ποσότητα αναστολέα διπεπτιδυλικής πεπτιδάσης IV (DPP-IV) έτσι ώστε ότι ο συνδυασμός να παρέχει ένα αποτέλεσμα στο χαμήλωμα ενός επιπέδου γλυκόζης αίματος ή στην αύξηση ενός επιπέδου GLP-1 αίματος σε ένα υποκείμενο έναντι εκείνου που παρέχεται από την ποσότητα του αγωνιστή GPR119 ή την ποσότητα του αναστολέα DPP-IV μόνη και τη χρήση ενός τέτοιου συνδυασμού για τη θεραπεία ή την πρόληψη του διαβήτη και των παθήσεων σχετικών με αυτόν ή των παθήσεων που βελτιώνονται με την αύξηση ενός επιπέδου GLP-1 αίματος. Η παρούσα εφεύρεση αναφέρεται επίσης στην χρήση ενός υποδοχέα συζευγμένου με την πρωτεΐνη G στην διαλογή για τα διεγερτικά έκκρισης GLP-1.
CY20091100816T 2005-01-10 2009-08-03 Μεθοδος αναγνωρισης των διεγερτικων εκκρισης glp-1 CY1109260T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64308605P 2005-01-10 2005-01-10
US68317205P 2005-05-19 2005-05-19
US72688005P 2005-10-14 2005-10-14
EP06717678A EP1758565B2 (en) 2005-01-10 2006-01-09 Method of identifying GLP-1 secretagogues

Publications (1)

Publication Number Publication Date
CY1109260T1 true CY1109260T1 (el) 2014-07-02

Family

ID=36570727

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100816T CY1109260T1 (el) 2005-01-10 2009-08-03 Μεθοδος αναγνωρισης των διεγερτικων εκκρισης glp-1
CY20091100881T CY1109321T1 (el) 2005-01-10 2009-08-19 Θεραπεια συνδυασμου για την θεραπεια του διαβητη και των παθησεων συγγενων με αυτον και για την θεραπεια των παθησεων που βελτιωνονται με την αυξηση ενος επιπεδου glp-1 αιματος

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20091100881T CY1109321T1 (el) 2005-01-10 2009-08-19 Θεραπεια συνδυασμου για την θεραπεια του διαβητη και των παθησεων συγγενων με αυτον και για την θεραπεια των παθησεων που βελτιωνονται με την αυξηση ενος επιπεδου glp-1 αιματος

Country Status (36)

Country Link
US (12) US20060154866A1 (el)
EP (9) EP1758565B2 (el)
JP (8) JP4118323B1 (el)
KR (5) KR20070095400A (el)
CN (2) CN103611161A (el)
AR (1) AR052082A1 (el)
AT (2) ATE432693T1 (el)
AU (3) AU2006205164B2 (el)
BR (1) BRPI0606727A (el)
CA (2) CA2654733C (el)
CL (1) CL2010000565A1 (el)
CR (1) CR9220A (el)
CY (2) CY1109260T1 (el)
DE (2) DE602006006765D1 (el)
DK (2) DK1758565T4 (el)
DO (2) DOP2006000008A (el)
EA (1) EA011883B1 (el)
ES (2) ES2327872T3 (el)
GT (1) GT200600004A (el)
HK (2) HK1100353A1 (el)
HN (1) HN2006000971A (el)
HR (2) HRP20090403T4 (el)
IL (1) IL184364A0 (el)
MX (1) MX2007008376A (el)
NI (1) NI200700174A (el)
NO (2) NO331089B1 (el)
NZ (4) NZ578504A (el)
PA (1) PA8659301A1 (el)
PE (2) PE20100398A1 (el)
PL (2) PL1758565T5 (el)
PT (2) PT1758565E (el)
RS (2) RS51174B (el)
SG (2) SG158876A1 (el)
SI (2) SI1808168T1 (el)
TW (1) TW200637534A (el)
WO (1) WO2006076231A2 (el)

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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
KR20110010824A (ko) 2003-01-14 2011-02-07 아레나 파마슈티칼스, 인크. 대사 조절제로서의 １,２,３-삼치환된 아릴 및 헤테로아릴 유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된 장애의 예방 및 치료
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MY157911A (en) 2003-07-14 2016-08-15 Arena Pharm Inc Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1838311A1 (en) * 2004-12-24 2007-10-03 Prosidion Limited G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
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