MX2019011867A - Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva. - Google Patents

Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva.

Info

Publication number
MX2019011867A
MX2019011867A MX2019011867A MX2019011867A MX2019011867A MX 2019011867 A MX2019011867 A MX 2019011867A MX 2019011867 A MX2019011867 A MX 2019011867A MX 2019011867 A MX2019011867 A MX 2019011867A MX 2019011867 A MX2019011867 A MX 2019011867A
Authority
MX
Mexico
Prior art keywords
pparî3
treatment
subject
progressive supranuclear
supranuclear palsy
Prior art date
Application number
MX2019011867A
Other languages
English (en)
Inventor
Finck Barbara
E Weinstein David
K Jain Sarita
Original Assignee
Coherus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coherus Biosciences Inc filed Critical Coherus Biosciences Inc
Publication of MX2019011867A publication Critical patent/MX2019011867A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Métodos para el tratamiento de la parálisis supranuclear progresiva o sus síntomas, con agonistas de PPAR? y, en particular, el compuesto de fórmula (I) conocido como INT131: (ver formula) También se proporcionan métodos para tratar un sujeto que incluyen seleccionar un sujeto que tiene un nivel elevado de proteína neurofilamentosa de cadena ligera en una muestra obtenida del sujeto, en comparación con un nivel de referencia de proteína neurofilamentosa de cadena ligera, y administrar una composición farmacéutica que incluye una cantidad terapéuticamente eficaz de un compuesto de fórmula (I) al sujeto seleccionado.
MX2019011867A 2017-04-03 2018-04-03 Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva. MX2019011867A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762480838P 2017-04-03 2017-04-03
US201862651653P 2018-04-02 2018-04-02
PCT/US2018/025923 WO2018187350A1 (en) 2017-04-03 2018-04-03 PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY

Publications (1)

Publication Number Publication Date
MX2019011867A true MX2019011867A (es) 2020-01-09

Family

ID=62028150

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011867A MX2019011867A (es) 2017-04-03 2018-04-03 Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva.

Country Status (12)

Country Link
US (1) US11253508B2 (es)
EP (1) EP3606527A1 (es)
JP (1) JP2020515639A (es)
KR (1) KR20200036808A (es)
CN (1) CN110996951A (es)
AU (1) AU2018249822A1 (es)
BR (1) BR112019020485A2 (es)
CA (1) CA3058806A1 (es)
IL (1) IL269705A (es)
MX (1) MX2019011867A (es)
SG (1) SG11201909046XA (es)
WO (1) WO2018187350A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100222489A1 (en) 2009-02-27 2010-09-02 Jiang Dayue D Copolymer composition, membrane article, and methods thereof
SG10202103552XA (en) 2015-03-09 2021-05-28 Intekrin Therapeutics Inc Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
CN110996951A (zh) 2017-04-03 2020-04-10 科赫罗斯生物科学股份有限公司 治疗进行性核上性麻痹的PPARγ激动剂
EA201992364A1 (ru) * 2018-04-02 2020-03-23 Кохерус Байосайенсис Инк. АГОНИСТ PPARγ ДЛЯ ЛЕЧЕНИЯ ПРОГРЕССИРУЮЩЕГО НАДЪЯДЕРНОГО ПАРАЛИЧА

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