JP2010511063A5 - - Google Patents

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JP2010511063A5
JP2010511063A5 JP2009539485A JP2009539485A JP2010511063A5 JP 2010511063 A5 JP2010511063 A5 JP 2010511063A5 JP 2009539485 A JP2009539485 A JP 2009539485A JP 2009539485 A JP2009539485 A JP 2009539485A JP 2010511063 A5 JP2010511063 A5 JP 2010511063A5
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JP
Japan
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water
acetonitrile
compound
dimethylformamide
trifluoroethanol
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JP2009539485A
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English (en)
Japanese (ja)
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JP5284272B2 (ja
JP2010511063A (ja
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Priority claimed from PCT/US2007/085933 external-priority patent/WO2008067465A1/en
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JP2009539485A 2006-11-29 2007-11-29 2−[6−(3−アミノ−ピペリジン−1−イル)−3−メチル−2,4−ジオキソ−3,4−ジヒドロ−2h−ピリミジン−1−イルメチル]−4−フルオロ−ベンゾニトリルのコハク酸塩の多形及びこれらの使用方法 Active JP5284272B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86776406P 2006-11-29 2006-11-29
US60/867,764 2006-11-29
PCT/US2007/085933 WO2008067465A1 (en) 2006-11-29 2007-11-29 Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor

Publications (3)

Publication Number Publication Date
JP2010511063A JP2010511063A (ja) 2010-04-08
JP2010511063A5 true JP2010511063A5 (enExample) 2011-01-20
JP5284272B2 JP5284272B2 (ja) 2013-09-11

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JP2009539485A Active JP5284272B2 (ja) 2006-11-29 2007-11-29 2−[6−(3−アミノ−ピペリジン−1−イル)−3−メチル−2,4−ジオキソ−3,4−ジヒドロ−2h−ピリミジン−1−イルメチル]−4−フルオロ−ベンゾニトリルのコハク酸塩の多形及びこれらの使用方法

Country Status (22)

Country Link
US (3) US20080227798A1 (enExample)
EP (1) EP2102185B1 (enExample)
JP (1) JP5284272B2 (enExample)
KR (1) KR20090086619A (enExample)
CN (1) CN101573351B (enExample)
AR (1) AR064035A1 (enExample)
AU (1) AU2007325107A1 (enExample)
BR (1) BRPI0719365A2 (enExample)
CA (1) CA2670776A1 (enExample)
CL (1) CL2007003427A1 (enExample)
CR (1) CR10874A (enExample)
EA (1) EA200970519A1 (enExample)
EC (1) ECSP099465A (enExample)
IL (1) IL198866A0 (enExample)
MA (1) MA31140B1 (enExample)
MX (1) MX2009005588A (enExample)
NO (1) NO20092249L (enExample)
PE (1) PE20081394A1 (enExample)
TN (1) TN2009000215A1 (enExample)
TW (1) TW200838536A (enExample)
WO (1) WO2008067465A1 (enExample)
ZA (1) ZA200903870B (enExample)

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CN105524042B (zh) * 2014-10-22 2019-09-13 重庆医药工业研究院有限责任公司 一种制备曲格列汀的方法
CN105646446B (zh) * 2014-11-14 2018-09-28 瀚晖制药有限公司 一种纯化阿格列汀的方法
CN104829590B (zh) * 2015-04-08 2020-04-24 重庆医药工业研究院有限责任公司 一种纯化曲格列汀的方法
CN105622575A (zh) * 2015-06-16 2016-06-01 上海元智生物医药科技有限公司 曲格列汀的制备方法
CN105399725B (zh) * 2015-11-06 2018-09-07 杭州华东医药集团新药研究院有限公司 曲格列汀化合物其盐、晶体、药物组合物和用途
CN105669645B (zh) * 2016-02-18 2019-12-31 南京正大天晴制药有限公司 曲格列汀及其琥珀酸盐的制备方法
CN107434800A (zh) * 2016-05-27 2017-12-05 威海迪素制药有限公司 一种琥珀酸曲格列汀晶型a的制备方法
CN105949175A (zh) * 2016-05-31 2016-09-21 威海迪素制药有限公司 一种琥珀酸曲格列汀杂质c对照品的制备方法
CN106117179B (zh) * 2016-06-23 2019-03-15 江苏万川医疗健康产业集团有限公司 一种琥珀酸曲格列汀的精制方法
CN106074422A (zh) * 2016-07-27 2016-11-09 上海海虹实业(集团)巢湖今辰药业有限公司 一种琥珀酸曲格列汀口服固体制剂及其制备方法
CN106279104B (zh) * 2016-08-16 2019-04-26 杭州新博思生物医药有限公司 一种制备琥珀酸曲格列汀的工艺改进方法
CN108072709B (zh) * 2016-11-18 2020-11-24 广东东阳光药业有限公司 测定琥珀酸曲格列汀原料药中对映异构体含量的方法
CN106749176A (zh) * 2016-12-08 2017-05-31 郑州明泽医药科技有限公司 一种曲格列汀琥珀酸盐的纯化方法
CN109970706A (zh) * 2017-12-27 2019-07-05 徐州万邦金桥制药有限公司 一种琥珀酸曲格列汀a晶型的制备和精制方法
CN107963991A (zh) * 2017-12-29 2018-04-27 成都百裕制药股份有限公司 一种无定形托伐普坦的生产方法
CN109503551A (zh) * 2018-11-21 2019-03-22 安阳师范学院 一种曲格列汀的制备方法
CN110156750A (zh) * 2019-05-13 2019-08-23 无锡贝塔医药科技有限公司 嘧啶环14c标记的琥珀酸曲格列汀的制备方法
CN114105889B (zh) * 2021-12-16 2023-06-13 山东创新药物研发有限公司 一种dpp-iv抑制剂关键中间体的制备方法及其应用
CN115785066B (zh) * 2022-12-08 2024-05-31 广东工业大学 曲格列汀晶型f及其制备方法

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