JP2005516030A5 - - Google Patents
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- Publication number
- JP2005516030A5 JP2005516030A5 JP2003558007A JP2003558007A JP2005516030A5 JP 2005516030 A5 JP2005516030 A5 JP 2005516030A5 JP 2003558007 A JP2003558007 A JP 2003558007A JP 2003558007 A JP2003558007 A JP 2003558007A JP 2005516030 A5 JP2005516030 A5 JP 2005516030A5
- Authority
- JP
- Japan
- Prior art keywords
- meloxicam
- crystalline form
- temperature
- water
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims description 48
- 229960001929 meloxicam Drugs 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000002244 precipitate Substances 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 238000010992 reflux Methods 0.000 claims 10
- 239000000725 suspension Substances 0.000 claims 10
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 8
- 239000003960 organic solvent Substances 0.000 claims 8
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims 6
- 239000008096 xylene Substances 0.000 claims 6
- 238000010438 heat treatment Methods 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- 230000003595 spectral effect Effects 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- 238000001069 Raman spectroscopy Methods 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 238000001237 Raman spectrum Methods 0.000 claims 1
- IYWCBYFJFZCCGV-UHFFFAOYSA-N formamide;hydrate Chemical compound O.NC=O IYWCBYFJFZCCGV-UHFFFAOYSA-N 0.000 claims 1
- 238000002329 infrared spectrum Methods 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200102743A ES2223209B1 (es) | 2001-12-11 | 2001-12-11 | Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion. |
| PCT/ES2002/000539 WO2003057692A1 (es) | 2001-12-11 | 2002-11-19 | Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005516030A JP2005516030A (ja) | 2005-06-02 |
| JP2005516030A5 true JP2005516030A5 (enExample) | 2006-01-05 |
Family
ID=8499703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558007A Pending JP2005516030A (ja) | 2001-12-11 | 2002-11-19 | 新規な結晶性の形態のメロキシカム並びにそれらの製造及び相互転換方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6967248B2 (enExample) |
| EP (1) | EP1462451B1 (enExample) |
| JP (1) | JP2005516030A (enExample) |
| KR (1) | KR100919927B1 (enExample) |
| AT (1) | ATE318813T1 (enExample) |
| AU (1) | AU2002350753B2 (enExample) |
| CA (1) | CA2470164A1 (enExample) |
| DE (1) | DE60209537T2 (enExample) |
| DK (1) | DK1462451T3 (enExample) |
| ES (2) | ES2223209B1 (enExample) |
| HU (1) | HUP0402536A3 (enExample) |
| MX (1) | MXPA04005338A (enExample) |
| NO (1) | NO326746B1 (enExample) |
| NZ (1) | NZ533521A (enExample) |
| PL (1) | PL370435A1 (enExample) |
| PT (1) | PT1462451E (enExample) |
| WO (1) | WO2003057692A1 (enExample) |
| ZA (1) | ZA200404475B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
| DE10161077A1 (de) | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion |
| US8992980B2 (en) | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
| EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
| DE102004021281A1 (de) * | 2004-04-29 | 2005-11-24 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin |
| DE102004030409A1 (de) * | 2004-06-23 | 2006-01-26 | Boehringer Ingelheim Vetmedica Gmbh | Neue Verwendung von Meloxicam in der Veterinärmedizin |
| ITMI20041918A1 (it) | 2004-10-11 | 2005-01-11 | A M S A Anonima Materie Sintetiche Affini Spa | Processo di purificazione di meloxicam |
| HU227359B1 (en) * | 2004-12-18 | 2011-04-28 | Egis Gyogyszergyar Nyilvanosan Mikodi Ruszvunytarsasag | Process for producing meloxicam and meloxicam potassium salt of high purity |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| SG166115A1 (en) * | 2005-09-30 | 2010-11-29 | Boehringer Ingelheim Vetmed | Pharmaceutical preparation containing meloxicam |
| GB2443891B (en) * | 2006-11-20 | 2009-04-08 | Norbrook Lab Ltd | Process for the purification of meloxicam |
| EP2244712B1 (en) * | 2008-01-22 | 2015-08-05 | Thar Pharmaceuticals Inc. | In vivo studies of crystalline forms of meloxicam |
| EP2488145B1 (en) * | 2009-10-12 | 2024-04-24 | Boehringer Ingelheim Vetmedica GmbH | Containers for compositions comprising meloxicam |
| SG183846A1 (en) | 2010-03-03 | 2012-10-30 | Boehringer Ingelheim Vetmed | Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats |
| US9795568B2 (en) | 2010-05-05 | 2017-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Low concentration meloxicam tablets |
| CN103772378B (zh) * | 2014-01-26 | 2016-02-24 | 悦康药业集团有限公司 | 一种美洛昔康化合物及其片剂 |
| US20210322316A1 (en) * | 2016-11-18 | 2021-10-21 | Pacira Pharmaceuticals, Inc. | Zinc meloxicam complex microparticles and anesthetic formulations and processes for making the same |
| EP3541815A4 (en) * | 2016-11-18 | 2020-07-15 | Pacira Pharmaceuticals, Inc. | ZINC MELXICAM COMPLEX MICROPARTICLE MULTIVESICULAR LIPOSOME FORMULATIONS AND METHODS OF MAKING THE SAME |
| US20220184095A1 (en) | 2019-04-22 | 2022-06-16 | Mylan Specialty L.P. | Meloxicam co-crystal compositions |
| AU2021375409A1 (en) | 2020-11-06 | 2023-06-29 | Mylan Laboratories Ltd | Pharmaceutical composition comprising meloxicam |
| CN116421567B (zh) * | 2023-04-27 | 2025-02-07 | 浙江萃泽医药科技有限公司 | 一种稳定冻干制剂及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2756113A1 (de) * | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US6355666B1 (en) * | 2000-06-23 | 2002-03-12 | Medinox, Inc. | Protected forms of pharmacologically active agents and uses therefor |
-
2001
- 2001-12-11 ES ES200102743A patent/ES2223209B1/es not_active Expired - Fee Related
-
2002
- 2002-11-19 DE DE60209537T patent/DE60209537T2/de not_active Expired - Lifetime
- 2002-11-19 AT AT02785450T patent/ATE318813T1/de not_active IP Right Cessation
- 2002-11-19 AU AU2002350753A patent/AU2002350753B2/en not_active Ceased
- 2002-11-19 PL PL02370435A patent/PL370435A1/xx not_active Application Discontinuation
- 2002-11-19 MX MXPA04005338A patent/MXPA04005338A/es active IP Right Grant
- 2002-11-19 WO PCT/ES2002/000539 patent/WO2003057692A1/es not_active Ceased
- 2002-11-19 JP JP2003558007A patent/JP2005516030A/ja active Pending
- 2002-11-19 PT PT02785450T patent/PT1462451E/pt unknown
- 2002-11-19 DK DK02785450T patent/DK1462451T3/da active
- 2002-11-19 NZ NZ533521A patent/NZ533521A/en not_active IP Right Cessation
- 2002-11-19 HU HU0402536A patent/HUP0402536A3/hu unknown
- 2002-11-19 CA CA002470164A patent/CA2470164A1/en not_active Abandoned
- 2002-11-19 KR KR1020047008796A patent/KR100919927B1/ko not_active Expired - Fee Related
- 2002-11-19 EP EP02785450A patent/EP1462451B1/en not_active Expired - Lifetime
- 2002-11-19 ES ES02785450T patent/ES2259725T3/es not_active Expired - Lifetime
- 2002-12-09 US US10/314,542 patent/US6967248B2/en not_active Expired - Fee Related
-
2004
- 2004-06-07 ZA ZA200404475A patent/ZA200404475B/xx unknown
- 2004-07-12 NO NO20042936A patent/NO326746B1/no not_active IP Right Cessation
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