JP2005516030A - 新規な結晶性の形態のメロキシカム並びにそれらの製造及び相互転換方法 - Google Patents

新規な結晶性の形態のメロキシカム並びにそれらの製造及び相互転換方法 Download PDF

Info

Publication number
JP2005516030A
JP2005516030A JP2003558007A JP2003558007A JP2005516030A JP 2005516030 A JP2005516030 A JP 2005516030A JP 2003558007 A JP2003558007 A JP 2003558007A JP 2003558007 A JP2003558007 A JP 2003558007A JP 2005516030 A JP2005516030 A JP 2005516030A
Authority
JP
Japan
Prior art keywords
meloxicam
crystalline form
temperature
water
precipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003558007A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005516030A5 (enExample
Inventor
コッピ，ローラ
サンマルティ，マルティー バルトラ
カールボ，モントセラート クローサ
Original Assignee
エステベ キミカ，ソシエダ アノニマ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エステベ キミカ，ソシエダ アノニマ filed Critical エステベ キミカ，ソシエダ アノニマ
Publication of JP2005516030A publication Critical patent/JP2005516030A/ja
Publication of JP2005516030A5 publication Critical patent/JP2005516030A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
JP2003558007A 2001-12-11 2002-11-19 新規な結晶性の形態のメロキシカム並びにそれらの製造及び相互転換方法 Pending JP2005516030A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200102743A ES2223209B1 (es) 2001-12-11 2001-12-11 Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion.
PCT/ES2002/000539 WO2003057692A1 (es) 2001-12-11 2002-11-19 Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion

Publications (2)

Publication Number Publication Date
JP2005516030A true JP2005516030A (ja) 2005-06-02
JP2005516030A5 JP2005516030A5 (enExample) 2006-01-05

Family

ID=8499703

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003558007A Pending JP2005516030A (ja) 2001-12-11 2002-11-19 新規な結晶性の形態のメロキシカム並びにそれらの製造及び相互転換方法

Country Status (18)

Country Link
US (1) US6967248B2 (enExample)
EP (1) EP1462451B1 (enExample)
JP (1) JP2005516030A (enExample)
KR (1) KR100919927B1 (enExample)
AT (1) ATE318813T1 (enExample)
AU (1) AU2002350753B2 (enExample)
CA (1) CA2470164A1 (enExample)
DE (1) DE60209537T2 (enExample)
DK (1) DK1462451T3 (enExample)
ES (2) ES2223209B1 (enExample)
HU (1) HUP0402536A3 (enExample)
MX (1) MXPA04005338A (enExample)
NO (1) NO326746B1 (enExample)
NZ (1) NZ533521A (enExample)
PL (1) PL370435A1 (enExample)
PT (1) PT1462451E (enExample)
WO (1) WO2003057692A1 (enExample)
ZA (1) ZA200404475B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
DE10161077A1 (de) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
DE102004021281A1 (de) * 2004-04-29 2005-11-24 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin
DE102004030409A1 (de) * 2004-06-23 2006-01-26 Boehringer Ingelheim Vetmedica Gmbh Neue Verwendung von Meloxicam in der Veterinärmedizin
ITMI20041918A1 (it) 2004-10-11 2005-01-11 A M S A Anonima Materie Sintetiche Affini Spa Processo di purificazione di meloxicam
HU227359B1 (en) * 2004-12-18 2011-04-28 Egis Gyogyszergyar Nyilvanosan Mikodi Ruszvunytarsasag Process for producing meloxicam and meloxicam potassium salt of high purity
FR2889847B1 (fr) 2005-08-18 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique.
BRPI0617208A2 (pt) * 2005-09-30 2011-07-19 Boehringer Ingelheim Vetmed preparação farmacêutica contendo meloxicam
GB2443891B (en) * 2006-11-20 2009-04-08 Norbrook Lab Ltd Process for the purification of meloxicam
WO2009094155A1 (en) * 2008-01-22 2009-07-30 Thar Pharmaceuticals In vivo studies of crystalline forms of meloxicam
DK2488145T3 (da) * 2009-10-12 2024-07-22 Boehringer Ingelheim Vetmedica Gmbh Beholdere til sammensætninger omfattende meloxicam
CA2791805A1 (en) 2010-03-03 2011-09-09 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
CN103772378B (zh) * 2014-01-26 2016-02-24 悦康药业集团有限公司 一种美洛昔康化合物及其片剂
CN109983013A (zh) * 2016-11-18 2019-07-05 帕西拉制药有限公司 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法
US20210322316A1 (en) * 2016-11-18 2021-10-21 Pacira Pharmaceuticals, Inc. Zinc meloxicam complex microparticles and anesthetic formulations and processes for making the same
EP3958841A1 (en) 2019-04-22 2022-03-02 Mylan Specialty L.P. Meloxicam co-crystal compositions
WO2022097024A1 (en) 2020-11-06 2022-05-12 Mylan Laboratories Ltd Pharmaceutical composition comprising meloxicam
CN116421567B (zh) * 2023-04-27 2025-02-07 浙江萃泽医药科技有限公司 一种稳定冻干制剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US6355666B1 (en) * 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor

Also Published As

Publication number Publication date
EP1462451A1 (en) 2004-09-29
ES2223209A1 (es) 2005-02-16
ES2259725T3 (es) 2006-10-16
NO326746B1 (no) 2009-02-09
KR100919927B1 (ko) 2009-10-07
KR20040082380A (ko) 2004-09-24
NO20042936L (no) 2004-09-13
WO2003057692A1 (es) 2003-07-17
MXPA04005338A (es) 2005-03-31
DE60209537T2 (de) 2006-11-16
DK1462451T3 (da) 2006-06-12
ZA200404475B (en) 2005-06-07
PL370435A1 (en) 2005-05-30
PT1462451E (pt) 2006-07-31
US20030109701A1 (en) 2003-06-12
CA2470164A1 (en) 2003-07-17
ES2223209B1 (es) 2005-10-01
NZ533521A (en) 2005-07-29
ATE318813T1 (de) 2006-03-15
AU2002350753A1 (en) 2003-07-24
US6967248B2 (en) 2005-11-22
DE60209537D1 (de) 2006-04-27
HUP0402536A3 (en) 2011-03-28
HUP0402536A2 (hu) 2005-04-28
AU2002350753B2 (en) 2008-05-08
EP1462451B1 (en) 2006-03-01

Similar Documents

Publication Publication Date Title
JP2005516030A (ja) 新規な結晶性の形態のメロキシカム並びにそれらの製造及び相互転換方法
EP2343275A2 (fr) Procédé de préparation et forme cristalline I des énantiomères optiques du modafinil.
HRP20010514A2 (en) Telmisartan polymorphs, methods for producing same and their use in the preparation of a medicament
US5700820A (en) Polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation
JP2000511875A (ja) 抗糖尿病活性を増強されたトログリタゾンの新規な多形型及びそれらの製造方法
JPS6216460A (ja) インドールカルボキシアミドの新規な誘導体、その塩、その製造方法及び薬剤としての使用
WO2006024890A1 (en) Improved process for rabeprazole sodium in amorphous form
JP2006521340A (ja) ロシグリタゾン・マレイン酸塩の多形体の製法
JP3644998B2 (ja) ベンジリデン誘導体の結晶の選択的取得方法
CN115784998B (zh) 一锅法合成苯妥英的方法
CN101090900A (zh) 制备高纯度美洛昔康和美洛昔康钾盐的方法
JP7426832B2 (ja) 新規結晶構造を有するイグラチモド及びその製造方法
US20060025408A1 (en) Process for the preparation of crystalline form-1 of 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
EP1923392B1 (en) Process for the purification of meloxicam
US20100093804A1 (en) novel crystalline form of lansoprazole
JP2847522B2 (ja) ピロロ〔１，２―ａ〕ピロール―１―カルボン酸誘導体の製造法
JPS58183678A (ja) ｓｙｎ−（２−アミノチアゾ−ル−４−イル）（メトキシイミノ）酢酸のジメチルアセトアミド溶媒和物
JPH0739410B2 (ja) ６−（３−ジメチルアミノプロピオニル）フォルスコリンの新規製造法
AU700976B2 (en) Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation
CA1246066A (en) Method for the preparation of a pharmaceutically usable benzothiazine dioxide, and an intermediate for use in the method
WO2006080484A1 (ja) セフカペン ピボキシルのメタンスルホン酸塩
JPS62132870A (ja) Ｎ−（２−ヒドロキシエチル）−２−メチル−３−カルボン酸アミド−キノキサリン−１，４−ジ−ｎ−オキシドの精製法
JP2010208957A (ja) 結晶構造を有する５−｛４−［２−（５−エチル−２−ピリジル）エトキシ］ベンジル｝−２−イミノ−４−チアゾリジノン及びその製造方法
JP2006525256A (ja) 高純度ｒａｃ−１−｛４−［２−ヒドロキシ−３−（５−キノリルオキシ）プロピル］−ピペラジン−１−イル｝−２，２−ジフェニルエタン−１−オン・フマレートの製造方法及び高純度ｒａｃ−１−｛４−［２−ヒドロキシ−３−（５−キノリルオキシ）プロピル］−ピペラジン−１−イル｝−２，２−ジフェニルエタン−１−オン・フマレート

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051028

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090623

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090918

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090930

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091222

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100126