DE60209537T2 - Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander - Google Patents

Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander Download PDF

Info

Publication number
DE60209537T2
DE60209537T2 DE60209537T DE60209537T DE60209537T2 DE 60209537 T2 DE60209537 T2 DE 60209537T2 DE 60209537 T DE60209537 T DE 60209537T DE 60209537 T DE60209537 T DE 60209537T DE 60209537 T2 DE60209537 T2 DE 60209537T2
Authority
DE
Germany
Prior art keywords
meloxicam
crystalline form
temperature
water
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60209537T
Other languages
German (de)
English (en)
Other versions
DE60209537D1 (de
Inventor
S.A. Laura ESTEVE QUIMICA COPPI
Marti Bartra Sanmarti
S.A. Montserrat ESTEVE QUIMICA CLOSA CALVO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Publication of DE60209537D1 publication Critical patent/DE60209537D1/de
Application granted granted Critical
Publication of DE60209537T2 publication Critical patent/DE60209537T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
DE60209537T 2001-12-11 2002-11-19 Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander Expired - Lifetime DE60209537T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200102743A ES2223209B1 (es) 2001-12-11 2001-12-11 Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion.
ES200102743 2001-12-11
PCT/ES2002/000539 WO2003057692A1 (es) 2001-12-11 2002-11-19 Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion

Publications (2)

Publication Number Publication Date
DE60209537D1 DE60209537D1 (de) 2006-04-27
DE60209537T2 true DE60209537T2 (de) 2006-11-16

Family

ID=8499703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60209537T Expired - Lifetime DE60209537T2 (de) 2001-12-11 2002-11-19 Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander

Country Status (18)

Country Link
US (1) US6967248B2 (enExample)
EP (1) EP1462451B1 (enExample)
JP (1) JP2005516030A (enExample)
KR (1) KR100919927B1 (enExample)
AT (1) ATE318813T1 (enExample)
AU (1) AU2002350753B2 (enExample)
CA (1) CA2470164A1 (enExample)
DE (1) DE60209537T2 (enExample)
DK (1) DK1462451T3 (enExample)
ES (2) ES2223209B1 (enExample)
HU (1) HUP0402536A3 (enExample)
MX (1) MXPA04005338A (enExample)
NO (1) NO326746B1 (enExample)
NZ (1) NZ533521A (enExample)
PL (1) PL370435A1 (enExample)
PT (1) PT1462451E (enExample)
WO (1) WO2003057692A1 (enExample)
ZA (1) ZA200404475B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035107A1 (en) 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
DE10161077A1 (de) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
DE102004021281A1 (de) * 2004-04-29 2005-11-24 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin
DE102004030409A1 (de) * 2004-06-23 2006-01-26 Boehringer Ingelheim Vetmedica Gmbh Neue Verwendung von Meloxicam in der Veterinärmedizin
ITMI20041918A1 (it) 2004-10-11 2005-01-11 A M S A Anonima Materie Sintetiche Affini Spa Processo di purificazione di meloxicam
HU227359B1 (en) * 2004-12-18 2011-04-28 Egis Gyogyszergyar Nyilvanosan Mikodi Ruszvunytarsasag Process for producing meloxicam and meloxicam potassium salt of high purity
FR2889847B1 (fr) 2005-08-18 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique.
SG166115A1 (en) * 2005-09-30 2010-11-29 Boehringer Ingelheim Vetmed Pharmaceutical preparation containing meloxicam
GB2443891B (en) * 2006-11-20 2009-04-08 Norbrook Lab Ltd Process for the purification of meloxicam
EP2244712B1 (en) * 2008-01-22 2015-08-05 Thar Pharmaceuticals Inc. In vivo studies of crystalline forms of meloxicam
EP2488145B1 (en) * 2009-10-12 2024-04-24 Boehringer Ingelheim Vetmedica GmbH Containers for compositions comprising meloxicam
SG183846A1 (en) 2010-03-03 2012-10-30 Boehringer Ingelheim Vetmed Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
CN103772378B (zh) * 2014-01-26 2016-02-24 悦康药业集团有限公司 一种美洛昔康化合物及其片剂
US20210322316A1 (en) * 2016-11-18 2021-10-21 Pacira Pharmaceuticals, Inc. Zinc meloxicam complex microparticles and anesthetic formulations and processes for making the same
EP3541815A4 (en) * 2016-11-18 2020-07-15 Pacira Pharmaceuticals, Inc. ZINC MELXICAM COMPLEX MICROPARTICLE MULTIVESICULAR LIPOSOME FORMULATIONS AND METHODS OF MAKING THE SAME
US20220184095A1 (en) 2019-04-22 2022-06-16 Mylan Specialty L.P. Meloxicam co-crystal compositions
AU2021375409A1 (en) 2020-11-06 2023-06-29 Mylan Laboratories Ltd Pharmaceutical composition comprising meloxicam
CN116421567B (zh) * 2023-04-27 2025-02-07 浙江萃泽医药科技有限公司 一种稳定冻干制剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US6355666B1 (en) * 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor

Also Published As

Publication number Publication date
NZ533521A (en) 2005-07-29
DK1462451T3 (da) 2006-06-12
ES2223209B1 (es) 2005-10-01
JP2005516030A (ja) 2005-06-02
PL370435A1 (en) 2005-05-30
EP1462451B1 (en) 2006-03-01
KR100919927B1 (ko) 2009-10-07
PT1462451E (pt) 2006-07-31
EP1462451A1 (en) 2004-09-29
NO326746B1 (no) 2009-02-09
DE60209537D1 (de) 2006-04-27
WO2003057692A1 (es) 2003-07-17
CA2470164A1 (en) 2003-07-17
US6967248B2 (en) 2005-11-22
US20030109701A1 (en) 2003-06-12
MXPA04005338A (es) 2005-03-31
ATE318813T1 (de) 2006-03-15
HUP0402536A2 (hu) 2005-04-28
ZA200404475B (en) 2005-06-07
NO20042936L (no) 2004-09-13
KR20040082380A (ko) 2004-09-24
AU2002350753B2 (en) 2008-05-08
AU2002350753A1 (en) 2003-07-24
ES2223209A1 (es) 2005-02-16
HUP0402536A3 (en) 2011-03-28
ES2259725T3 (es) 2006-10-16

Similar Documents

Publication Publication Date Title
DE60209537T2 (de) Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander
CH648037A5 (de) Imidazo-rifamycin-derivate mit antibakterieller wirksamkeit.
DE2710632A1 (de) Alkylen- oder zykloalkylendiammonium- bis-tetrahalophthalat sowie verfahren zu seiner herstellung
DE60215213T2 (de) Herstellung von levofloxacin hemihydrat
DE60105441T2 (de) Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens
EP0386628A1 (de) Verfahren zur Herstellung von Indolcarbonsäurederivaten
EP0411408A1 (de) Monoklines Metazachlor und Verfahren zu seiner Herstellung
DE69300453T2 (de) Isoindolinon-derivat, seine herstellung und dieses enthaltende pharmazeutische zusammen setzungen.
DE2036027C3 (de) Pleuromutilin-Derivate und Verfahren zu ihrer Herstellung
EP0002747B1 (de) Neue Kristallmodifikation des 5-(2'-Hydroxy-3'-naphthoylamino)-benzimidazolon-(2), Verfahren zu ihrer Herstellung und ihre Verwendung
DE1804983A1 (de) Verfahren zur Herstellung von Cephalosporansaeurederivaten
AT209895B (de) Verfahren zur Herstellung von 3-Amino-2,4,6-trijodbenzoylverbindungen
DE2848926C3 (de) Derivate des 1,6,11,11a-Tetrahydro-[1,3-thiazino][3,4-b]isochinolins, ihre Herstellung und die sie enthaltenden Zusammensetzungen
DE2741066A1 (de) Neue rifamyzin-verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
AT332877B (de) Verfahren zur herstellung von neuen 6-aza-1,2-dihydro-3h-1,4- benzodiazepinen, deren optischen isomeren und deren salzen
DE3586150T2 (de) Amidderivate der 2-(p-aminobenzyl)-buttersaeure und ihrer ester mit blutfettgehaltsenkender wirkung.
DE69232916T2 (de) Verfahren zur Herstellung von 2-Amino-3-nitro-5-halogenopyridin
AT365200B (de) Verfahren zur herstellung von neuen thienothiazin-derivaten und von deren salzen
AT209007B (de) Verfahren zur Herstellung von 9 α-Halogen-4-pregnen-16 α, 17 α,21-triol-3, 11, 20-trionen und ihren Estern
AT262991B (de) Verfahren zur Herstellung von neuen Thienobenzothiazinderivaten
AT274801B (de) Verfahren zur Herstellung von neuen 1-Acyl-3-indolylcarbonsäureverbindungen
CH641174A5 (de) Verfahren zur herstellung von n-(4'-chlor-3'-sulfamoyl-benzolsulfonyl)-n-methyl-2-aminomethyl-2-methyl-tetrahydrofuran.
AT366672B (de) Verfahren zur herstellung neuer phthalazin-4-yl- essigsaeurederivate und von deren salzen
DE2053117C3 (de) 3-Amin-4,5-dehydro-cardenolide, Verfahren zu ihrer Herstellung und ihre Verwendung
DE883897C (de) Verfahren zur Herstellung von 17-(ª‡)-Oxy-20-ketopregnanen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition