JP2002539793A5 - - Google Patents
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- JP2002539793A5 JP2002539793A5 JP2000606759A JP2000606759A JP2002539793A5 JP 2002539793 A5 JP2002539793 A5 JP 2002539793A5 JP 2000606759 A JP2000606759 A JP 2000606759A JP 2000606759 A JP2000606759 A JP 2000606759A JP 2002539793 A5 JP2002539793 A5 JP 2002539793A5
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- 150000007523 nucleic acids Chemical group 0.000 description 23
- 239000002773 nucleotide Substances 0.000 description 21
- 125000003729 nucleotide group Chemical group 0.000 description 21
- 241000588724 Escherichia coli Species 0.000 description 16
- 229920001850 Nucleic acid sequence Polymers 0.000 description 12
- 108020004707 nucleic acids Proteins 0.000 description 11
- 229920001184 polypeptide Polymers 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002609 media Substances 0.000 description 3
- 229920002676 Complementary DNA Polymers 0.000 description 2
- 230000000295 complement Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002538 fungal Effects 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000001963 growth media Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 ポリペプチドを製造する方法であって、
（a）菌類宿主細胞を、ポリペプチドの製造を助ける培地中で培養し、菌類宿主細胞は、第１の核酸配列に対して外来のプロモーターを含む第２の核酸配列に機能しうる形で連結された、ポリペプチドをコードする第１の核酸配列を含み、かつ、前記プロモーターは、配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938および配列番号：３のヌクレオチド１〜3060並びにそのサブ配列；並びに、その変異体、ハイブリッドおよび縦列プロモーターからなる群より選択される配列を含み；そして
（b）培養培地からポリペプチドを分離する；
ことを含んで成る方法。
【請求項２】 前記プロモーターが、大腸菌（E. coli）NRRL B-30067に含有されるプラスミドpECO3；大腸菌（E. coli）NRRL B-30071に含有されるプラスミドpFAMG；または大腸菌（E. coli）NRRL B-30075に含有されるプラスミドpQUINNに含まれる核酸配列を含む請求項１記載の方法。
【請求項３】 配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938および配列番号：３のヌクレオチド１〜3060並びにそのサブ配列；ならびに、その変異体、ハイブリッドおよび縦列プロモーターからなる群より選択される核酸配列を含むプロモーター。
【請求項４】 大腸菌（E. coli）NRRL B-30067に含有されるプラスミドpECO3；大腸菌（E. coli）NRRL B-30071に含有されるプラスミドpFAMG；または大腸菌（E. coli）NRRL B-30075に含有されるプラスミドpQUINNに含まれる核酸配列を含む請求項３記載の単離されたプロモーター。
【請求項５】 請求項３記載のプロモーターに機能しうる形で連結された、ポリペプチドをコードする核酸配列を含む核酸構築物。
【請求項６】 請求項５記載の核酸構築物を含む組換え発現ベクター。
【請求項７】 請求項５記載の核酸構築物を含む組換え宿主細胞。
【請求項８】 変異体プロモーターを得るための方法であって、
（a）低いストリンジェンシー条件下でDNAを、（i）配列番号：１、配列番号：２もしくは配列番号：３、（ii）配列番号：１、配列番号：２もしくは配列番号：３に含まれるcDNA配列、（iii）前記（i）もしくは（ii）のサブ配列、または（iv）前記（i）、（ii）もしくは（iii）の相補鎖を含む核酸配列を用いてハイブリダイズし；そして
（b）DNAから変異体プロモーターを分離する；
ことを含んで成る方法。
【請求項９】 変異体プロモーターを得るための方法であって、（a）配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938または配列番号：３のヌクレオチド１〜3060のプロモーターに、少なくとも１つの変異を導入し、ここで変異体プロモーターは、配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938または配列番号：３のヌクレオチド１〜3060のプロモーターと同じプロモーター活性を有し；そして（b）変異体プロモーターを単離することを含む方法。
【請求項１０】 （a）配列番号：４のアミノ酸22〜581、配列番号：５のアミノ酸19〜200または配列番号：６のアミノ酸１〜187と少なくとも65％の同一性を有するアミノ酸配列を含むポリペプチドをコードする核酸配列；
（b）配列番号：１のヌクレオチド4013〜5743、配列番号：２のヌクレオチド993〜1593または配列番号：３のヌクレオチド3061〜3678と少なくとも65％の相同性を有する核酸配列；
（c）中間の、中〜高い、高い、または非常に高いストリンジェンシー条件下で、（i）配列番号：１のヌクレオチド4013〜5743、配列番号：２のヌクレオチド993〜1593もしくは配列番号：３のヌクレオチド3061〜3678；（ii）配列番号：１のヌクレオチド4013〜5743、配列番号：２のヌクレオチド993〜1593もしくは配列番号：３のヌクレオチド3061〜3678に含まれるcDNA配列、または（iii）前記（i）もしくは（ii）の相補鎖とハイブリダイズする核酸配列；
（d）前記（a）、（b）または（c）の対立遺伝子変異体；ならびに
（e）活性を保持するポリペプチドをコードする、（a）、（b）、（c）または（d）のサブ配列；
からなる群より選択される核酸配列を有する核酸。
【請求項１１】 大腸菌（E. coli）NRRL B-30067に含有されるプラスミドpECO3；大腸菌（E. coli）NRRL B-30071に含有されるプラスミドpFAMG；または大腸菌（E. coli）NRRL B-30075に含有されるプラスミドpQUINNに含まれる核酸配列を含む請求項10記載の核酸。
【請求項１２】 適当な発現宿主中でポリペプチドの製造を指令する、１つ以上の制御配列に機能しうるように連結された、請求項10記載の核酸を含む核酸構築物。
【請求項１３】 請求項12記載の核酸構築物を含む組換え発現ベクター。
【請求項１４】 請求項12記載の核酸構築物を含む組換え宿主細胞。
【請求項１５】 請求項10記載の核酸によってコードされるポリペプチド。
【請求項１】 ポリペプチドを製造する方法であって、
（a）菌類宿主細胞を、ポリペプチドの製造を助ける培地中で培養し、菌類宿主細胞は、第１の核酸配列に対して外来のプロモーターを含む第２の核酸配列に機能しうる形で連結された、ポリペプチドをコードする第１の核酸配列を含み、かつ、前記プロモーターは、配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938および配列番号：３のヌクレオチド１〜3060並びにそのサブ配列；並びに、その変異体、ハイブリッドおよび縦列プロモーターからなる群より選択される配列を含み；そして
（b）培養培地からポリペプチドを分離する；
ことを含んで成る方法。
【請求項２】 前記プロモーターが、大腸菌（E. coli）NRRL B-30067に含有されるプラスミドpECO3；大腸菌（E. coli）NRRL B-30071に含有されるプラスミドpFAMG；または大腸菌（E. coli）NRRL B-30075に含有されるプラスミドpQUINNに含まれる核酸配列を含む請求項１記載の方法。
【請求項３】 配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938および配列番号：３のヌクレオチド１〜3060並びにそのサブ配列；ならびに、その変異体、ハイブリッドおよび縦列プロモーターからなる群より選択される核酸配列を含むプロモーター。
【請求項４】 大腸菌（E. coli）NRRL B-30067に含有されるプラスミドpECO3；大腸菌（E. coli）NRRL B-30071に含有されるプラスミドpFAMG；または大腸菌（E. coli）NRRL B-30075に含有されるプラスミドpQUINNに含まれる核酸配列を含む請求項３記載の単離されたプロモーター。
【請求項５】 請求項３記載のプロモーターに機能しうる形で連結された、ポリペプチドをコードする核酸配列を含む核酸構築物。
【請求項６】 請求項５記載の核酸構築物を含む組換え発現ベクター。
【請求項７】 請求項５記載の核酸構築物を含む組換え宿主細胞。
【請求項８】 変異体プロモーターを得るための方法であって、
（a）低いストリンジェンシー条件下でDNAを、（i）配列番号：１、配列番号：２もしくは配列番号：３、（ii）配列番号：１、配列番号：２もしくは配列番号：３に含まれるcDNA配列、（iii）前記（i）もしくは（ii）のサブ配列、または（iv）前記（i）、（ii）もしくは（iii）の相補鎖を含む核酸配列を用いてハイブリダイズし；そして
（b）DNAから変異体プロモーターを分離する；
ことを含んで成る方法。
【請求項９】 変異体プロモーターを得るための方法であって、（a）配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938または配列番号：３のヌクレオチド１〜3060のプロモーターに、少なくとも１つの変異を導入し、ここで変異体プロモーターは、配列番号：１のヌクレオチド１〜3949、配列番号：２のヌクレオチド１〜938または配列番号：３のヌクレオチド１〜3060のプロモーターと同じプロモーター活性を有し；そして（b）変異体プロモーターを単離することを含む方法。
【請求項１０】 （a）配列番号：４のアミノ酸22〜581、配列番号：５のアミノ酸19〜200または配列番号：６のアミノ酸１〜187と少なくとも65％の同一性を有するアミノ酸配列を含むポリペプチドをコードする核酸配列；
（b）配列番号：１のヌクレオチド4013〜5743、配列番号：２のヌクレオチド993〜1593または配列番号：３のヌクレオチド3061〜3678と少なくとも65％の相同性を有する核酸配列；
（c）中間の、中〜高い、高い、または非常に高いストリンジェンシー条件下で、（i）配列番号：１のヌクレオチド4013〜5743、配列番号：２のヌクレオチド993〜1593もしくは配列番号：３のヌクレオチド3061〜3678；（ii）配列番号：１のヌクレオチド4013〜5743、配列番号：２のヌクレオチド993〜1593もしくは配列番号：３のヌクレオチド3061〜3678に含まれるcDNA配列、または（iii）前記（i）もしくは（ii）の相補鎖とハイブリダイズする核酸配列；
（d）前記（a）、（b）または（c）の対立遺伝子変異体；ならびに
（e）活性を保持するポリペプチドをコードする、（a）、（b）、（c）または（d）のサブ配列；
からなる群より選択される核酸配列を有する核酸。
【請求項１１】 大腸菌（E. coli）NRRL B-30067に含有されるプラスミドpECO3；大腸菌（E. coli）NRRL B-30071に含有されるプラスミドpFAMG；または大腸菌（E. coli）NRRL B-30075に含有されるプラスミドpQUINNに含まれる核酸配列を含む請求項10記載の核酸。
【請求項１２】 適当な発現宿主中でポリペプチドの製造を指令する、１つ以上の制御配列に機能しうるように連結された、請求項10記載の核酸を含む核酸構築物。
【請求項１３】 請求項12記載の核酸構築物を含む組換え発現ベクター。
【請求項１４】 請求項12記載の核酸構築物を含む組換え宿主細胞。
【請求項１５】 請求項10記載の核酸によってコードされるポリペプチド。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27444999A | 1999-03-22 | 1999-03-22 | |
| US09/274,449 | 1999-03-22 | ||
| PCT/US2000/007815 WO2000056900A2 (en) | 1999-03-22 | 2000-03-22 | Promoter sequences derived from fusarium venenatum and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010109995A Division JP5264825B2 (ja) | 1999-03-22 | 2010-05-12 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539793A JP2002539793A (ja) | 2002-11-26 |
| JP2002539793A5 true JP2002539793A5 (ja) | 2007-05-17 |
| JP4620253B2 JP4620253B2 (ja) | 2011-01-26 |
Family
ID=23048245
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606759A Expired - Fee Related JP4620253B2 (ja) | 1999-03-22 | 2000-03-22 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
| JP2010109995A Expired - Fee Related JP5264825B2 (ja) | 1999-03-22 | 2010-05-12 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
| JP2013021124A Pending JP2013121360A (ja) | 1999-03-22 | 2013-02-06 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
| JP2013021169A Ceased JP2013121361A (ja) | 1999-03-22 | 2013-02-06 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010109995A Expired - Fee Related JP5264825B2 (ja) | 1999-03-22 | 2010-05-12 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
| JP2013021124A Pending JP2013121360A (ja) | 1999-03-22 | 2013-02-06 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
| JP2013021169A Ceased JP2013121361A (ja) | 1999-03-22 | 2013-02-06 | 菌類細胞中で遺伝子を発現させるためのプロモーター |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2278016B1 (ja) |
| JP (4) | JP4620253B2 (ja) |
| CN (5) | CN100482801C (ja) |
| AU (1) | AU4025700A (ja) |
| DK (1) | DK2278016T3 (ja) |
| WO (1) | WO2000056900A2 (ja) |
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| DE10036491A1 (de) | 2000-07-25 | 2002-02-07 | Roche Diagnostics Gmbh | Expression von Alkalischer Phosphatase in Hefe |
| US7063962B2 (en) * | 2001-07-20 | 2006-06-20 | Novozymes A/S | DNA sequences for regulating transcription |
| AUPR945901A0 (en) * | 2001-12-13 | 2002-01-24 | Macquarie University | Gene promoters |
| CN101497908B (zh) * | 2002-11-18 | 2014-05-21 | 诺维信股份有限公司 | 用于在真菌细胞中表达基因的启动子变体 |
| CN101629204A (zh) | 2003-03-31 | 2010-01-20 | 诺维信股份有限公司 | 在缺乏酶的黑曲霉突变体中生产生物物质的方法 |
| CN1902310B (zh) | 2003-10-28 | 2011-09-21 | 诺维信股份有限公司 | 具有β-葡糖苷酶活性的多肽和编码所述多肽的多核苷酸 |
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| EP1715736A4 (en) | 2004-02-12 | 2008-09-03 | Novozymes Inc | POLYPEPTIDES HAVING XYLANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME |
| PT3219806T (pt) | 2004-03-25 | 2020-06-30 | Novozymes Inc | Métodos para degradar ou converter polissacarídeos da parede celular de plantas |
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| US9045748B2 (en) | 2004-05-27 | 2015-06-02 | Novozymes, Inc. | Methods for transforming and expression screening of filamentous fungal cells with a DNA library |
| CN1308452C (zh) * | 2004-09-14 | 2007-04-04 | 上海永业农科生物工程有限公司 | 一种含有改组乙醇氧化酶启动子的毕赤酵母植酸酶表达系统 |
| EP2298872A3 (en) | 2004-09-30 | 2011-08-10 | Novozymes A/S | Polypeptides having lipase activity and polynucleotides encoding same |
| AR050895A1 (es) | 2004-10-04 | 2006-11-29 | Novozymes As | Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican |
| BRPI0517539A (pt) | 2004-10-04 | 2008-10-14 | Novozymes As | polipeptìdeo isolado, polinucleotìdeo isolado, construto de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, métodos para produzir o polipeptìdeo, e para melhorar o valor nutricional de uma ração animal, célula de planta, parte de planta ou planta transgênica, animal não-humano, transgênico, ou produtos, ou elementos do mesmo, uso de pelo menos um polipeptìdeo, aditivo de ração animal, e, composição de ração animal |
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| MX2023001888A (es) | 2020-08-25 | 2023-03-10 | Novozymes As | Variantes de una xiloglucanasa de la familia 44. |
| EP4204548A1 (en) | 2020-08-28 | 2023-07-05 | Novozymes A/S | Polyester degrading protease variants |
| EP4229189A1 (en) | 2020-10-13 | 2023-08-23 | Novozymes A/S | Glycosyltransferase variants for improved protein production |
| US20240035005A1 (en) | 2020-10-29 | 2024-02-01 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| WO2022090555A1 (en) | 2020-11-02 | 2022-05-05 | Novozymes A/S | Leader peptides and polynucleotides encoding the same |
| MX2023004938A (es) | 2020-11-02 | 2023-05-17 | Novozymes As | Variantes de glucoamilasa y polinucleotidos que codifican las mismas. |
| EP4026900A3 (en) | 2020-12-17 | 2022-10-05 | Fornia BioSolutions, Inc. | Xylanase variants and methods |
| WO2022175440A1 (en) | 2021-02-18 | 2022-08-25 | Novozymes A/S | Inactive heme polypeptides |
| EP4305146A1 (en) | 2021-03-12 | 2024-01-17 | Novozymes A/S | Polypeptide variants |
| EP4060036A1 (en) | 2021-03-15 | 2022-09-21 | Novozymes A/S | Polypeptide variants |
| WO2022197512A1 (en) | 2021-03-15 | 2022-09-22 | The Procter & Gamble Company | Cleaning compositions containing polypeptide variants |
| US20240060061A1 (en) | 2021-03-15 | 2024-02-22 | Novozymes A/S | Dnase variants |
| AU2022270929A1 (en) | 2021-05-07 | 2023-10-19 | River Stone Biotech Aps | Glycosylated opioids |
| EP4347813A1 (en) | 2021-05-27 | 2024-04-10 | Novozymes A/S | Transcriptional regulators and polynucleotides encoding the same |
| WO2022268885A1 (en) | 2021-06-23 | 2022-12-29 | Novozymes A/S | Alpha-amylase polypeptides |
| WO2023006699A1 (en) | 2021-07-30 | 2023-02-02 | Københavns Universitet | Cells and method for producing isoprenoid molecules with canonical and non-canonical structures |
| WO2024100063A1 (en) | 2022-11-08 | 2024-05-16 | River Stone Biotech Aps | Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| EP0305216B1 (en) | 1987-08-28 | 1995-08-02 | Novo Nordisk A/S | Recombinant Humicola lipase and process for the production of recombinant humicola lipases |
| DE69129988T2 (de) | 1990-09-13 | 1999-03-18 | Novo Nordisk As | Lipase-varianten |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| GB9316883D0 (en) * | 1993-08-13 | 1993-09-29 | Univ Leeds | Production of heterologous peptices |
| AU694954B2 (en) | 1994-06-03 | 1998-08-06 | Novo Nordisk A/S | Purified myceliophthora laccases and nucleic acids encoding same |
| CN1151762A (zh) * | 1994-06-30 | 1997-06-11 | 诺沃诺尔迪斯克生物技术有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| DE69733121T2 (de) | 1996-01-19 | 2006-03-02 | Novozymes Biotech, Inc., Davis | Morphologische mutanten von filamentösen pilzen |
| CN1190673A (zh) * | 1996-04-29 | 1998-08-19 | 中国科学院微生物研究所 | 丝状真菌中独立复制的表达载体及表达系统 |
| EP0966521A1 (en) | 1996-09-13 | 1999-12-29 | Novo Nordisk Biotech, Inc. | Cells having dna insertion mutations which produce altered amounts of a polypeptide |
| ATE195140T1 (de) | 1996-12-20 | 2000-08-15 | Novo Nordisk As | Peniophora phytase |
-
2000
- 2000-03-22 JP JP2000606759A patent/JP4620253B2/ja not_active Expired - Fee Related
- 2000-03-22 EP EP10180302A patent/EP2278016B1/en not_active Expired - Lifetime
- 2000-03-22 CN CNB008053324A patent/CN100482801C/zh not_active Expired - Fee Related
- 2000-03-22 EP EP00919596A patent/EP1194572A2/en not_active Withdrawn
- 2000-03-22 WO PCT/US2000/007815 patent/WO2000056900A2/en active Application Filing
- 2000-03-22 AU AU40257/00A patent/AU4025700A/en not_active Abandoned
- 2000-03-22 CN CNB2004100314912A patent/CN100510096C/zh not_active Expired - Fee Related
- 2000-03-22 CN CN 200410031492 patent/CN1526820B/zh not_active Expired - Fee Related
- 2000-03-22 DK DK10180302.1T patent/DK2278016T3/da active
- 2000-03-22 CN CNA2006100999266A patent/CN1940067A/zh active Pending
- 2000-03-22 CN CNB2004100314931A patent/CN100532561C/zh not_active Expired - Fee Related
-
2010
- 2010-05-12 JP JP2010109995A patent/JP5264825B2/ja not_active Expired - Fee Related
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2013
- 2013-02-06 JP JP2013021124A patent/JP2013121360A/ja active Pending
- 2013-02-06 JP JP2013021169A patent/JP2013121361A/ja not_active Ceased
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