HRP20190826T1 - Konjugati oligonukleotida - Google Patents

Konjugati oligonukleotida Download PDF

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Publication number
HRP20190826T1
HRP20190826T1 HRP20190826TT HRP20190826T HRP20190826T1 HR P20190826 T1 HRP20190826 T1 HR P20190826T1 HR P20190826T T HRP20190826T T HR P20190826TT HR P20190826 T HRP20190826 T HR P20190826T HR P20190826 T1 HRP20190826 T1 HR P20190826T1
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Croatia
Prior art keywords
region
oligomeric compound
compound according
group
phosphodiester
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HRP20190826TT
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English (en)
Croatian (hr)
Inventor
Nanna ALBÆK
Henrik Frydenlund Hansen
Susanne KAMMLER
Jacob Ravn
Henrik ØRUM
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Roche Innovation Center Copenhagen A/S
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Publication of HRP20190826T1 publication Critical patent/HRP20190826T1/hr

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/30—Chemical structure
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    • C12N2310/3517—Marker; Tag
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HRP20190826TT 2012-11-15 2013-11-14 Konjugati oligonukleotida HRP20190826T1 (hr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27
EP13791808.2A EP2920304B1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
HRP20190826T1 true HRP20190826T1 (hr) 2019-06-28

Family

ID=49584733

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20190826TT HRP20190826T1 (hr) 2012-11-15 2013-11-14 Konjugati oligonukleotida

Country Status (22)

Country Link
US (4) US10077443B2 (enExample)
EP (3) EP2920304B1 (enExample)
JP (3) JP2016503300A (enExample)
KR (2) KR102112892B1 (enExample)
CN (3) CN104884618A (enExample)
AU (2) AU2013346767B2 (enExample)
BR (2) BR112015011112A2 (enExample)
CA (2) CA2889044A1 (enExample)
DK (2) DK2920307T3 (enExample)
ES (1) ES2724853T3 (enExample)
HK (2) HK1210213A1 (enExample)
HR (1) HRP20190826T1 (enExample)
IL (2) IL238448B (enExample)
MX (2) MX2015005792A (enExample)
MY (1) MY173826A (enExample)
NZ (1) NZ708171A (enExample)
PL (1) PL2920304T3 (enExample)
RU (3) RU2018112970A (enExample)
SG (2) SG10201804331TA (enExample)
SI (1) SI2920304T1 (enExample)
WO (2) WO2014076196A1 (enExample)
ZA (1) ZA201503375B (enExample)

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