ES2724853T3 - Conjugados de oligonucleótidos - Google Patents

Conjugados de oligonucleótidos Download PDF

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Publication number
ES2724853T3
ES2724853T3 ES13791808T ES13791808T ES2724853T3 ES 2724853 T3 ES2724853 T3 ES 2724853T3 ES 13791808 T ES13791808 T ES 13791808T ES 13791808 T ES13791808 T ES 13791808T ES 2724853 T3 ES2724853 T3 ES 2724853T3
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region
group
oligomer
lna
conjugate
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Spanish (es)
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Nanna Albæk
Henrik Frydenlund Hansen
Susanne Kammler
Jacob Ravn
HENRIK øRUM
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Roche Innovation Center Copenhagen AS
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Roche Innovation Center Copenhagen AS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
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    • C12N2330/30—Production chemically synthesised

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ES13791808T 2012-11-15 2013-11-14 Conjugados de oligonucleótidos Active ES2724853T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
ES2724853T3 true ES2724853T3 (es) 2019-09-16

Family

ID=49584733

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ES13791808T Active ES2724853T3 (es) 2012-11-15 2013-11-14 Conjugados de oligonucleótidos

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US (4) US20150291958A1 (enExample)
EP (3) EP2920307B1 (enExample)
JP (3) JP6452614B2 (enExample)
KR (2) KR20150083920A (enExample)
CN (3) CN117126846A (enExample)
AU (2) AU2013346767B2 (enExample)
BR (2) BR112015011112A2 (enExample)
CA (2) CA2889596C (enExample)
DK (2) DK2920307T3 (enExample)
ES (1) ES2724853T3 (enExample)
HK (2) HK1210213A1 (enExample)
HR (1) HRP20190826T1 (enExample)
IL (2) IL238448B (enExample)
MX (2) MX2015005792A (enExample)
MY (1) MY173826A (enExample)
NZ (1) NZ708171A (enExample)
PL (1) PL2920304T3 (enExample)
RU (3) RU2015119411A (enExample)
SG (2) SG11201503821YA (enExample)
SI (1) SI2920304T1 (enExample)
WO (2) WO2014076196A1 (enExample)
ZA (1) ZA201503375B (enExample)

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