ZA201503375B - Oligonucleotide conjugates - Google Patents

Oligonucleotide conjugates

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Publication number
ZA201503375B
ZA201503375B ZA2015/03375A ZA201503375A ZA201503375B ZA 201503375 B ZA201503375 B ZA 201503375B ZA 2015/03375 A ZA2015/03375 A ZA 2015/03375A ZA 201503375 A ZA201503375 A ZA 201503375A ZA 201503375 B ZA201503375 B ZA 201503375B
Authority
ZA
South Africa
Prior art keywords
oligonucleotide conjugates
conjugates
oligonucleotide
Prior art date
Application number
ZA2015/03375A
Other languages
English (en)
Inventor
HENRIK øRUM
Jacob Ravn
Susanne Kammler
Henrik Frydenlund Hansen
Nanna Albæk
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of ZA201503375B publication Critical patent/ZA201503375B/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2310/30—Chemical structure
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    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
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    • C12N2330/30—Production chemically synthesised

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ZA2015/03375A 2012-11-15 2015-05-14 Oligonucleotide conjugates ZA201503375B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
ZA201503375B true ZA201503375B (en) 2016-02-24

Family

ID=49584733

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2015/03375A ZA201503375B (en) 2012-11-15 2015-05-14 Oligonucleotide conjugates

Country Status (22)

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US (4) US10077443B2 (enExample)
EP (3) EP2920307B1 (enExample)
JP (3) JP2016503300A (enExample)
KR (2) KR20150083920A (enExample)
CN (3) CN104837996A (enExample)
AU (2) AU2013346767B2 (enExample)
BR (2) BR112015011112A2 (enExample)
CA (2) CA2889044A1 (enExample)
DK (2) DK2920307T3 (enExample)
ES (1) ES2724853T3 (enExample)
HK (2) HK1210213A1 (enExample)
HR (1) HRP20190826T1 (enExample)
IL (2) IL238448B (enExample)
MX (2) MX2015005792A (enExample)
MY (1) MY173826A (enExample)
NZ (1) NZ708171A (enExample)
PL (1) PL2920304T3 (enExample)
RU (3) RU2653438C2 (enExample)
SG (2) SG10201804331TA (enExample)
SI (1) SI2920304T1 (enExample)
WO (2) WO2014076196A1 (enExample)
ZA (1) ZA201503375B (enExample)

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