HRP20110473T1 - Supstituirani derivati 1-heterociklilsulfonil, 2-aminometil, 5-(hetero)-aril 1-h-pirola kao inhibitori kiselinske sekrecije - Google Patents
Supstituirani derivati 1-heterociklilsulfonil, 2-aminometil, 5-(hetero)-aril 1-h-pirola kao inhibitori kiselinske sekrecije Download PDFInfo
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- HRP20110473T1 HRP20110473T1 HR20110473T HRP20110473T HRP20110473T1 HR P20110473 T1 HRP20110473 T1 HR P20110473T1 HR 20110473 T HR20110473 T HR 20110473T HR P20110473 T HRP20110473 T HR P20110473T HR P20110473 T1 HRP20110473 T1 HR P20110473T1
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- 125000003118 aryl group Chemical group 0.000 title claims abstract 6
- 239000003112 inhibitor Substances 0.000 title claims 4
- 230000009858 acid secretion Effects 0.000 title claims 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 58
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 31
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 23
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims abstract 22
- 125000001769 aryl amino group Chemical group 0.000 claims abstract 21
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 20
- 125000004434 sulfur atom Chemical group 0.000 claims abstract 20
- 125000005842 heteroatom Chemical group 0.000 claims abstract 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 19
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 19
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims abstract 18
- 150000001875 compounds Chemical class 0.000 claims abstract 18
- 125000005974 C6-C14 arylcarbonyl group Chemical group 0.000 claims abstract 17
- 229910052799 carbon Inorganic materials 0.000 claims abstract 17
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 17
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims abstract 16
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 16
- 125000001424 substituent group Chemical group 0.000 claims abstract 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 14
- -1 thiocarbamoyl Chemical group 0.000 claims abstract 14
- 125000003396 thiol group Chemical class [H]S* 0.000 claims abstract 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 12
- 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims abstract 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 11
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract 11
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims abstract 10
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims abstract 10
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims abstract 10
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 10
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract 10
- 125000003277 amino group Chemical group 0.000 claims abstract 10
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims abstract 10
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims abstract 10
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims abstract 10
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims abstract 10
- 125000005110 aryl thio group Chemical group 0.000 claims abstract 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract 10
- 125000004122 cyclic group Chemical group 0.000 claims abstract 10
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims abstract 9
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims abstract 9
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims abstract 9
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims abstract 9
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims abstract 9
- 125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 claims abstract 8
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims abstract 8
- 125000005530 alkylenedioxy group Chemical group 0.000 claims abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 8
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims abstract 7
- 125000005116 aryl carbamoyl group Chemical group 0.000 claims abstract 7
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 5
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims abstract 4
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000004429 atom Chemical group 0.000 claims abstract 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims abstract 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000002252 acyl group Chemical group 0.000 claims 16
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 14
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 13
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 claims 6
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 claims 5
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000008469 Peptic Ulcer Diseases 0.000 claims 4
- 230000002496 gastric effect Effects 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 208000011906 peptic ulcer disease Diseases 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 206010063655 Erosive oesophagitis Diseases 0.000 claims 2
- 208000007882 Gastritis Diseases 0.000 claims 2
- 206010017866 Gastritis haemorrhagic Diseases 0.000 claims 2
- 206010020601 Hyperchlorhydria Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 206010042220 Stress ulcer Diseases 0.000 claims 2
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000037328 acute stress Effects 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 208000000718 duodenal ulcer Diseases 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000017215 gastric mucosa-associated lymphoid tissue lymphoma Diseases 0.000 claims 2
- 201000000052 gastrinoma Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 208000000689 peptic esophagitis Diseases 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 230000035882 stress Effects 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- GKYNXSVMESZZIF-UHFFFAOYSA-N 1-(4-fluoro-5-phenyl-1-pyridin-3-ylsulfonylpyrrol-3-yl)-n-methylmethanamine Chemical group FC=1C(CNC)=CN(S(=O)(=O)C=2C=NC=CC=2)C=1C1=CC=CC=C1 GKYNXSVMESZZIF-UHFFFAOYSA-N 0.000 claims 1
- GLTCPTOZHSIXQA-UHFFFAOYSA-N 1-[5-(2-fluorophenyl)-1-(6-methylpyridin-3-yl)sulfonylpyrrol-3-yl]-n-methylmethanamine Chemical group C=1C=C(C)N=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1F GLTCPTOZHSIXQA-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- SRTTWNYIEACZDL-UHFFFAOYSA-N n-methyl-1-[5-(2-methylphenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]methanamine Chemical group C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1C SRTTWNYIEACZDL-UHFFFAOYSA-N 0.000 claims 1
- RXQZPPFNPSUVQJ-UHFFFAOYSA-N n-methyl-1-[5-(4-methylthiophen-3-yl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]methanamine Chemical group C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CSC=C1C RXQZPPFNPSUVQJ-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Chemical group 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- BFDBKMOZYNOTPK-UHFFFAOYSA-N vonoprazan Chemical group C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1F BFDBKMOZYNOTPK-UHFFFAOYSA-N 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005250356 | 2005-08-30 | ||
| JP2006100626 | 2006-03-31 | ||
| PCT/JP2006/317408 WO2007026916A1 (en) | 2005-08-30 | 2006-08-29 | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110473T1 true HRP20110473T1 (hr) | 2011-07-31 |
Family
ID=37517870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110473T HRP20110473T1 (hr) | 2005-08-30 | 2011-06-27 | Supstituirani derivati 1-heterociklilsulfonil, 2-aminometil, 5-(hetero)-aril 1-h-pirola kao inhibitori kiselinske sekrecije |
| HRP20120792TT HRP20120792T1 (hr) | 2005-08-30 | 2012-10-03 | 1-heterociklilsulfonil, 2-aminometil, 5-(hetero)-aril supstituirani 1-h-pirol derivati kao inhibitori sekrecije želuäśanje kiseline |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120792TT HRP20120792T1 (hr) | 2005-08-30 | 2012-10-03 | 1-heterociklilsulfonil, 2-aminometil, 5-(hetero)-aril supstituirani 1-h-pirol derivati kao inhibitori sekrecije želuäśanje kiseline |
Country Status (33)
| Country | Link |
|---|---|
| US (7) | US7977488B2 (zh) |
| EP (2) | EP2327692B9 (zh) |
| JP (3) | JP4035559B1 (zh) |
| KR (2) | KR101408561B1 (zh) |
| CN (1) | CN101300229B (zh) |
| AR (1) | AR055144A1 (zh) |
| AT (1) | ATE504567T1 (zh) |
| AU (1) | AU2006285641A1 (zh) |
| BR (2) | BRPI0615111B8 (zh) |
| CA (1) | CA2621182C (zh) |
| CR (1) | CR9755A (zh) |
| CY (2) | CY1111922T1 (zh) |
| DE (1) | DE602006021195D1 (zh) |
| DK (2) | DK1919865T3 (zh) |
| ES (2) | ES2391757T3 (zh) |
| GE (1) | GEP20105044B (zh) |
| HK (2) | HK1118547A1 (zh) |
| HR (2) | HRP20110473T1 (zh) |
| IL (1) | IL189375A (zh) |
| JO (1) | JO2791B1 (zh) |
| MA (1) | MA29773B1 (zh) |
| ME (1) | MEP10009A (zh) |
| NO (1) | NO341894B1 (zh) |
| NZ (1) | NZ566378A (zh) |
| PE (2) | PE20070540A1 (zh) |
| PL (2) | PL2327692T3 (zh) |
| PT (2) | PT1919865E (zh) |
| RS (2) | RS51697B (zh) |
| SI (2) | SI2327692T1 (zh) |
| TW (1) | TWI358296B (zh) |
| UA (1) | UA94424C2 (zh) |
| WO (1) | WO2007026916A1 (zh) |
| ZA (1) | ZA200802488B (zh) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4035559B1 (ja) * | 2005-08-30 | 2008-01-23 | 武田薬品工業株式会社 | 酸分泌抑制薬としての１−ヘテロシクリルスルホニル、２−アミノメチル、５−（ヘテロ−）アリール置換１−ｈ−ピロール誘導体 |
| US8933105B2 (en) * | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| KR101558011B1 (ko) * | 2007-09-28 | 2015-10-06 | 다케다 야쿠힌 고교 가부시키가이샤 | 양성자 펌프 억제제로서의 5-원 이종원자고리 화합물 |
| WO2009041447A1 (ja) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | ５員複素環化合物 |
| EP2210876B1 (en) | 2007-11-01 | 2015-05-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound as glucagon antagonist |
| EP2309985B1 (en) | 2008-07-28 | 2018-03-14 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| WO2010021149A1 (ja) * | 2008-08-21 | 2010-02-25 | 武田薬品工業株式会社 | 酸分泌抑制スピロ化合物 |
| BRPI0917705A2 (pt) * | 2008-08-27 | 2016-02-16 | Takeda Pharmaceutical | composto, pró-droga, composição farmacêutica, método para tratar ou prevenir uma doença ou condição, e, uso do composto |
| EP3929187A3 (en) * | 2009-02-25 | 2022-02-16 | Takeda Pharmaceutical Company Limited | Process for producing pyrrole compound |
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