CN106243008B - 富马酸沃诺拉赞中间体5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法 - Google Patents
富马酸沃诺拉赞中间体5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法 Download PDFInfo
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- CN106243008B CN106243008B CN201610701882.3A CN201610701882A CN106243008B CN 106243008 B CN106243008 B CN 106243008B CN 201610701882 A CN201610701882 A CN 201610701882A CN 106243008 B CN106243008 B CN 106243008B
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- Prior art keywords
- pyrroles
- fluorophenyls
- reaction
- formaldehyde
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- 0 CC(C1=CCCC=C1*)=NCC=C Chemical compound CC(C1=CCCC=C1*)=NCC=C 0.000 description 3
- ZBFYXICYYHHAOL-GNXRPPCSSA-N CC/C=C(\C(\F)=C/CC)/c1cc(C)c[nH]1 Chemical compound CC/C=C(\C(\F)=C/CC)/c1cc(C)c[nH]1 ZBFYXICYYHHAOL-GNXRPPCSSA-N 0.000 description 1
- LCCGIVIFPUDRQC-UHFFFAOYSA-N Cc(cc1-c2cc(CBr)c[nH]2)ccc1F Chemical compound Cc(cc1-c2cc(CBr)c[nH]2)ccc1F LCCGIVIFPUDRQC-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610701882.3A CN106243008B (zh) | 2016-08-22 | 2016-08-22 | 富马酸沃诺拉赞中间体5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法 |
Applications Claiming Priority (1)
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CN201610701882.3A CN106243008B (zh) | 2016-08-22 | 2016-08-22 | 富马酸沃诺拉赞中间体5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN106243008A CN106243008A (zh) | 2016-12-21 |
CN106243008B true CN106243008B (zh) | 2018-09-04 |
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CN201610701882.3A Active CN106243008B (zh) | 2016-08-22 | 2016-08-22 | 富马酸沃诺拉赞中间体5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113845459B (zh) * | 2021-10-14 | 2023-04-07 | 山东诚创蓝海医药科技有限公司 | 一种5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1803709A1 (en) * | 2004-09-30 | 2007-07-04 | Takeda Pharmaceutical Company Limited | Proton pump inhibitors |
CN101300229A (zh) * | 2005-08-30 | 2008-11-05 | 武田药品工业株式会社 | 作为胃酸分泌抑制剂的1-杂环基磺酰基、2-氨基甲基、5-(杂)芳基取代的1-h-吡咯衍生物 |
CN102421753A (zh) * | 2009-02-25 | 2012-04-18 | 武田药品工业株式会社 | 制备吡咯化合物的方法 |
CN104356043A (zh) * | 2014-11-27 | 2015-02-18 | 重庆威尔德浩瑞医药化工有限公司 | 一种制备5-(2-氟苯基)-1h-吡咯-3-甲醛的方法 |
CN105294653A (zh) * | 2015-11-16 | 2016-02-03 | 山东罗欣药业集团股份有限公司 | 富马酸沃诺拉赞的制备工艺 |
-
2016
- 2016-08-22 CN CN201610701882.3A patent/CN106243008B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1803709A1 (en) * | 2004-09-30 | 2007-07-04 | Takeda Pharmaceutical Company Limited | Proton pump inhibitors |
CN101300229A (zh) * | 2005-08-30 | 2008-11-05 | 武田药品工业株式会社 | 作为胃酸分泌抑制剂的1-杂环基磺酰基、2-氨基甲基、5-(杂)芳基取代的1-h-吡咯衍生物 |
CN102421753A (zh) * | 2009-02-25 | 2012-04-18 | 武田药品工业株式会社 | 制备吡咯化合物的方法 |
CN104356043A (zh) * | 2014-11-27 | 2015-02-18 | 重庆威尔德浩瑞医药化工有限公司 | 一种制备5-(2-氟苯基)-1h-吡咯-3-甲醛的方法 |
CN105294653A (zh) * | 2015-11-16 | 2016-02-03 | 山东罗欣药业集团股份有限公司 | 富马酸沃诺拉赞的制备工艺 |
Non-Patent Citations (3)
Title |
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5-(2-氟苯基)吡咯-3-甲醛的合成工艺研究;徐成, 等.;《精细化工中间体》;20150831;第45卷(第4期);第46-48页 * |
Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1 H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB);Yasuyoshi Arikawa, et al.;《Journal of Medicinal Chemistry》;20120418;第55卷;第4446-4456页 * |
α-Palladation of Imines as Entry to Dehydrogenative Heck Reaction: Aerobic Oxidative Cyclization of N-Allylimines to Pyrroles;Zhiyuan Chen, et al.;《Organic Letters》;20130402;第15卷(第8期);第1966-1969页 * |
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Publication number | Publication date |
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CN106243008A (zh) | 2016-12-21 |
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Address after: 255129 Zichuan District Economic Development Zone, Zibo, Shandong Applicant after: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. Address before: 255129 Zichuan District Economic Development Zone, Zibo, Shandong Applicant before: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. |
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Effective date of registration: 20180730 Address after: 255100 North East Road West of Jiao Wang Road, Zichuan District Economic Development Zone, Zibo, Shandong Applicant after: SHANDONG JINCHENG BIO-PHARMACEUTICAL CO.,LTD. Address before: 255129 Zichuan District Economic Development Zone, Zibo, Shandong Applicant before: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. |
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