DK2327692T3 - 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-substituerede 1-H-pyrrol-derivater som syresekretionshæmmere. - Google Patents

1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-substituerede 1-H-pyrrol-derivater som syresekretionshæmmere.

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Publication number
DK2327692T3
DK2327692T3 DK11155996.9T DK11155996T DK2327692T3 DK 2327692 T3 DK2327692 T3 DK 2327692T3 DK 11155996 T DK11155996 T DK 11155996T DK 2327692 T3 DK2327692 T3 DK 2327692T3
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DK
Denmark
Prior art keywords
heterocyclylsulfonyl
aminomethyl
hetero
aryl
substituted
Prior art date
Application number
DK11155996.9T
Other languages
English (en)
Other versions
DK2327692T5 (da
Inventor
Masahiro Kajino
Atsushi Hasuoka
Haruyuki Nishida
Original Assignee
Takeda Pharmaceutical
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Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of DK2327692T3 publication Critical patent/DK2327692T3/da
Application granted granted Critical
Publication of DK2327692T5 publication Critical patent/DK2327692T5/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
DK11155996.9T 2005-08-30 2006-08-29 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-substituerede 1-H-pyrrol-derivater som syresekretionshæmmere. DK2327692T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005250356 2005-08-30
JP2006100626 2006-03-31
EP06797335A EP1919865B1 (en) 2005-08-30 2006-08-29 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors

Publications (2)

Publication Number Publication Date
DK2327692T3 true DK2327692T3 (da) 2012-10-15
DK2327692T5 DK2327692T5 (da) 2014-06-23

Family

ID=37517870

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11155996.9T DK2327692T5 (da) 2005-08-30 2006-08-29 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-substituerede 1-H-pyrrol-derivater som syresekretionshæmmere.
DK06797335.4T DK1919865T3 (da) 2005-08-30 2006-08-29 1-Heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-substituerede 1-h-pyrrolderivater som syresekretionsinhibitorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06797335.4T DK1919865T3 (da) 2005-08-30 2006-08-29 1-Heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-substituerede 1-h-pyrrolderivater som syresekretionsinhibitorer

Country Status (33)

Country Link
US (7) US7498337B2 (da)
EP (2) EP1919865B1 (da)
JP (3) JP4035559B1 (da)
KR (2) KR101408561B1 (da)
CN (1) CN101300229B (da)
AR (1) AR055144A1 (da)
AT (1) ATE504567T1 (da)
AU (1) AU2006285641A1 (da)
BR (2) BR122017028096B8 (da)
CA (1) CA2621182C (da)
CR (1) CR9755A (da)
CY (2) CY1111922T1 (da)
DE (1) DE602006021195D1 (da)
DK (2) DK2327692T5 (da)
ES (2) ES2391757T3 (da)
GE (1) GEP20105044B (da)
HK (2) HK1118547A1 (da)
HR (2) HRP20110473T1 (da)
IL (1) IL189375A (da)
JO (1) JO2791B1 (da)
MA (1) MA29773B1 (da)
ME (1) ME00610B (da)
NO (1) NO341894B1 (da)
NZ (1) NZ566378A (da)
PE (2) PE20110009A1 (da)
PL (2) PL2327692T3 (da)
PT (2) PT1919865E (da)
RS (2) RS52473B9 (da)
SI (2) SI2327692T1 (da)
TW (1) TWI358296B (da)
UA (1) UA94424C2 (da)
WO (1) WO2007026916A1 (da)
ZA (1) ZA200802488B (da)

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US20090156642A1 (en) * 2007-09-28 2009-06-18 Takeda Pharmaceutical Company Limited 5-Membered heterocyclic compound
EP2196459B1 (en) 2007-09-28 2016-11-02 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compound
JP5450083B2 (ja) 2007-11-01 2014-03-26 武田薬品工業株式会社 複素環化合物
PE20110591A1 (es) 2008-07-28 2011-09-15 Takeda Pharmaceutical Composicion farmaceutica estabilizada a base de un compuesto no peptidico
WO2010021149A1 (ja) * 2008-08-21 2010-02-25 武田薬品工業株式会社 酸分泌抑制スピロ化合物
KR101629181B1 (ko) * 2008-08-27 2016-06-13 다케다 야쿠힌 고교 가부시키가이샤 피롤 화합물
JP5628787B2 (ja) * 2009-02-25 2014-11-19 武田薬品工業株式会社 ピロール化合物の製造法
EA019853B1 (ru) 2009-03-26 2014-06-30 Такеда Фармасьютикал Компани Лимитед Производные 1-(пиридин-3-ил)-3-метиламинометил-5-фенилсульфонилпиразола
WO2011004882A1 (ja) * 2009-07-09 2011-01-13 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
WO2012095691A1 (en) * 2011-01-15 2012-07-19 Jubilant Life Sciences Ltd. An improved process for producing aminopyridines
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
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KR102129842B1 (ko) 2013-10-02 2020-07-06 주식회사 대웅제약 술포닐인돌 유도체 및 이의 제조방법
CN103951652B (zh) * 2014-04-18 2015-09-23 潍坊博创国际生物医药研究院 5-(2-氟苯基)-n-甲基-1-(3-吡啶基磺酰基)-1h-吡咯-3-甲胺水溶性有机酸盐和注射剂及它们的制备方法
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
CN105646451A (zh) * 2014-11-12 2016-06-08 江苏豪森药业集团有限公司 钾离子竞争性酸阻滞剂的晶型及其制备方法
CN107001262A (zh) * 2014-11-19 2017-08-01 江苏豪森药业集团有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其晶型、中间体和医药用途
CN104447490B (zh) * 2014-11-19 2017-06-06 连云港恒运医药有限公司 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途
CN104447491B (zh) * 2014-11-19 2017-06-23 连云港恒运医药有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其中间体和医药用途
CN105693693A (zh) * 2014-11-27 2016-06-22 江苏柯菲平医药股份有限公司 一种吡咯类胃酸分泌和抑制剂化合物盐的制备
CN104356043B (zh) * 2014-11-27 2016-10-26 重庆威尔德浩瑞医药化工有限公司 一种制备5-(2-氟苯基)-1h-吡咯-3-甲醛的方法
CN105708812A (zh) * 2014-12-02 2016-06-29 江苏柯菲平医药股份有限公司 一种5-（2-氟苯基）-n-甲基-1-（3-吡啶基磺酰基）-1h-吡咯-3-甲氨冻干粉针及其制备方法
CN104860923B (zh) * 2015-01-21 2018-01-12 山东康美乐医药科技有限公司 富马酸沃诺拉赞的制备方法
CN105985278A (zh) * 2015-01-27 2016-10-05 江苏柯菲平医药股份有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用
CN105982867A (zh) * 2015-02-27 2016-10-05 江苏柯菲平医药股份有限公司 一种h009冻干粉针及其制备方法
CN106031710B (zh) * 2015-03-16 2019-03-12 南京优科制药有限公司 一种富马酸氟呐普拉赞的注射剂及其制备方法
CN104814964B (zh) * 2015-04-16 2018-07-31 广东赛烽医药科技有限公司 一种抗胃幽门螺旋杆菌的药物组合物、制备方法及其应用
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
CN105315258A (zh) * 2015-05-16 2016-02-10 南京海纳医药科技有限公司 富马酸沃诺拉赞多晶型及其制备方法
CN104860926B (zh) * 2015-06-10 2017-06-30 浙江诚意药业股份有限公司 一种富马酸沃诺拉赞的制备方法
CN104945313A (zh) * 2015-06-19 2015-09-30 洪帅金 一种2-甲基-3-溴吡啶的制备方法
CN104926790B (zh) * 2015-06-29 2017-07-07 江苏奥赛康药业股份有限公司 一种高纯度Vonoprazan Fumarate化合物及其中间体、杂质以及它们的制备方法
EP4257577A3 (en) 2015-06-30 2023-12-20 Takeda Pharmaceutical Company Limited Method for producing pyrrole compound
CN104974082A (zh) * 2015-07-26 2015-10-14 陈吉美 一种2-甲基-4-溴吡啶的制备方法
CN106432191A (zh) * 2015-08-10 2017-02-22 陕西合成药业股份有限公司 一种新的吡咯类衍生物、其制备方法及其在医药上的应用
CN105106203B (zh) * 2015-08-17 2019-04-05 江苏豪森药业集团有限公司 富马酸沃诺拉赞的药物组合物及其制备方法
CN105085484B (zh) * 2015-08-21 2017-11-24 南京济群医药科技股份有限公司 一种富马酸沃诺拉赞的制备方法
CN105030725B (zh) * 2015-08-26 2019-12-10 迪沙药业集团有限公司 一种富马酸沃诺拉赞肠溶组合物及其制备方法
CN105030720B (zh) * 2015-08-26 2019-12-10 迪沙药业集团有限公司 一种富马酸沃诺拉赞肠溶片及其制备方法
CN106478597A (zh) * 2015-09-02 2017-03-08 中美华世通生物医药科技（武汉）有限公司 富马酸沃诺拉赞单晶及其制备方法和用途
CN106511344A (zh) * 2015-09-14 2017-03-22 王虹 一种胃酸分泌抑制剂的新用途
CN106632246A (zh) * 2015-10-30 2017-05-10 江苏柯菲平医药股份有限公司 一种吡咯类胃酸分泌抑制剂化合物盐的晶型及其制备
CN105198802A (zh) * 2015-11-03 2015-12-30 江苏梦得电镀化学品有限公司 一种2-甲基-3-溴吡啶的制备方法
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