HK1204656A1 - Methods and compositions involving mirna and mirna inhibitor molecules - Google Patents
Methods and compositions involving mirna and mirna inhibitor molecules Download PDFInfo
- Publication number
- HK1204656A1 HK1204656A1 HK15105287.4A HK15105287A HK1204656A1 HK 1204656 A1 HK1204656 A1 HK 1204656A1 HK 15105287 A HK15105287 A HK 15105287A HK 1204656 A1 HK1204656 A1 HK 1204656A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- mir
- seq
- mirna
- hsa
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3527—Other alkyl chain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3535—Nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62717104P | 2004-11-12 | 2004-11-12 | |
| US627171P | 2004-11-12 | ||
| US64963405P | 2005-02-03 | 2005-02-03 | |
| US649634P | 2005-02-03 | ||
| US68373605P | 2005-05-23 | 2005-05-23 | |
| US683736P | 2005-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1204656A1 true HK1204656A1 (en) | 2015-11-27 |
Family
ID=37570916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15105287.4A HK1204656A1 (en) | 2004-11-12 | 2015-06-03 | Methods and compositions involving mirna and mirna inhibitor molecules |
Country Status (11)
| Country | Link |
|---|---|
| US (25) | US8173611B2 (cg-RX-API-DMAC7.html) |
| EP (21) | EP2292755A1 (cg-RX-API-DMAC7.html) |
| JP (11) | JP2008519606A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005333165B2 (cg-RX-API-DMAC7.html) |
| CA (7) | CA2857880A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2302055T3 (cg-RX-API-DMAC7.html) |
| ES (13) | ES2534304T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1204656A1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2302055T3 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2302055T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006137941A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (409)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2428568B1 (en) | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| EP1791954A1 (en) * | 2004-09-07 | 2007-06-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| US7825229B2 (en) * | 2005-03-25 | 2010-11-02 | Rosetta Genomics Ltd. | Lung cancer-related nucleic acids |
| US20090186353A1 (en) * | 2004-10-04 | 2009-07-23 | Rosetta Genomics Ltd. | Cancer-related nucleic acids |
| AU2005333165B2 (en) * | 2004-11-12 | 2012-07-19 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| WO2008073922A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| CA2603881A1 (en) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| US8247543B2 (en) | 2005-04-29 | 2012-08-21 | The Rockefeller University | Human microRNAs and methods for inhibiting same |
| US20090209621A1 (en) * | 2005-06-03 | 2009-08-20 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
| CN102533966B (zh) | 2005-08-01 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CA2845251A1 (en) * | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof |
| EP1940456A4 (en) * | 2005-10-05 | 2009-10-21 | Univ Ohio State Res Found | WWOX GENE, VECTORS COMPRISING THE SAME, AND USES THEREOF IN THE TREATMENT OF CANCER |
| PL1969125T3 (pl) | 2005-12-12 | 2012-11-30 | Univ North Carolina Chapel Hill | Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych |
| AU2016203848B2 (en) * | 2006-01-05 | 2017-12-14 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2514434B1 (en) | 2006-01-05 | 2015-10-21 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer |
| EP2479286B1 (en) * | 2006-01-05 | 2013-11-13 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
| CA2646051A1 (en) * | 2006-03-20 | 2007-09-27 | Carlo M. Croce | Microrna fingerprints during human megakaryocytopoiesis |
| US20100004320A1 (en) | 2006-04-03 | 2010-01-07 | Santaris Pharma A/S | Pharmaceutical Composition |
| EA201100813A1 (ru) | 2006-04-03 | 2012-06-29 | Сантарис Фарма А/С | Фармацевтическая композиция |
| ES2562607T3 (es) | 2006-07-13 | 2016-03-07 | The Ohio State University Research Foundation | MIR-21 para el diagnóstico de adenocarcinoma de colon con mal pronóstico de supervivencia |
| ES2397439T3 (es) | 2006-08-01 | 2013-03-07 | Board Of Regents Of The University Of Texas System | Identificación de un microARN que activa la expresión de la cadena pesada beta de la miosina |
| CN101541972A (zh) † | 2006-08-04 | 2009-09-23 | 都柏林城市大学 | 生产重组生物产品的方法 |
| ES2534430T3 (es) * | 2006-08-28 | 2015-04-22 | The University Of Western Australia | Método de modulación de la expresión del receptor del factor de crecimiento epidérmico (EGFR) que implica miARN |
| WO2008029790A1 (fr) * | 2006-09-04 | 2008-03-13 | Kyowa Hakko Kirin Co., Ltd. | Nouvel acide nucléique |
| CN101535505A (zh) | 2006-09-19 | 2009-09-16 | 俄亥俄州立大学研究基金会 | 慢性淋巴细胞性白血病(CLL)中受miR-29和miR-181调控的TCL1的表达 |
| CA2663962A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| US7803784B2 (en) * | 2006-10-24 | 2010-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of T cell signaling threshold and T cell sensitivity to antigens |
| AU2007314212B2 (en) | 2006-11-01 | 2014-05-29 | The Govt. Of The Usa As Represented By The Secretary Of The Department Of Health And Human Services | MicroRNA expression signature for predicting survival and metastases in Hepatocellular carcinoma |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CA2671194A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| AU2007333107A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-21 regulated genes and pathways as targets for therapeutic intervention |
| CN101622349A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-21调节的基因和途径 |
| WO2008073921A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-126 regulated genes and pathways as targets for therapeutic intervention |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| US20100298407A1 (en) * | 2007-01-17 | 2010-11-25 | The Johns Hopkins University | Compositions and methods featuring micronas for treating neoplasia |
| CN103555825B (zh) | 2007-01-31 | 2015-09-30 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| US8765702B2 (en) | 2007-02-27 | 2014-07-01 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| US9006206B2 (en) | 2007-02-27 | 2015-04-14 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| WO2008107901A2 (en) * | 2007-03-07 | 2008-09-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
| US8841436B2 (en) * | 2007-03-15 | 2014-09-23 | University Hospitals Cleveland Medical Center | Screening, diagnosing, treating and prognosis of pathophysiologic status by RNA regulation |
| EP2136846A4 (en) * | 2007-03-26 | 2011-04-13 | Crc For Asthma And Airways Ltd | THERAPEUTIC OBJECTIVES AND MOLECULES |
| US20100273172A1 (en) * | 2007-03-27 | 2010-10-28 | Rosetta Genomics Ltd. | Micrornas expression signature for determination of tumors origin |
| US20090117562A1 (en) | 2007-04-09 | 2009-05-07 | Valerie Wailin Hu | Method and kit for diagnosing Autism using gene expression profiling |
| WO2008136971A1 (en) * | 2007-04-30 | 2008-11-13 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| EP1990414A1 (en) * | 2007-05-10 | 2008-11-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Means for treating inflammatory diseases, autoimmune diseases and cancer |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US8415096B2 (en) * | 2007-05-23 | 2013-04-09 | University Of South Florida | Micro-RNAs modulating immunity and inflammation |
| AU2008262252B2 (en) | 2007-06-08 | 2013-09-12 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells |
| CN101801419A (zh) * | 2007-06-08 | 2010-08-11 | 米尔纳疗法公司 | 作为治疗干预的靶标的miR-34调控的基因和路径 |
| AU2008266014B2 (en) | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| US20090012031A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | EZH2 Cancer Markers |
| CN101883576B (zh) | 2007-07-31 | 2015-08-19 | 得克萨斯系统大学董事会 | 调控纤维化的微小rna家族及其用途 |
| CN101808649B (zh) | 2007-07-31 | 2014-05-21 | 得克萨斯系统大学董事会 | 控制肌球蛋白表达和肌纤维身份的微小rna |
| WO2009018303A2 (en) | 2007-07-31 | 2009-02-05 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting dnmt3a and dnmt3b |
| EP2185700A4 (en) * | 2007-08-02 | 2010-11-24 | Texas A & M Univ Sys | Antisense microrna and uses therefor |
| CA2695514A1 (en) | 2007-08-03 | 2009-02-12 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| WO2009021235A2 (en) * | 2007-08-09 | 2009-02-12 | The Regents Of The University Of Colorado | Methods and compositions for treating cancer |
| US8716255B2 (en) | 2007-08-10 | 2014-05-06 | British Columbia Cancer Agency Branch | Microrna compositions and methods for the treatment of myelogenous leukemia |
| AU2008288806B2 (en) | 2007-08-22 | 2014-11-27 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias |
| CN101376910B (zh) * | 2007-08-27 | 2012-01-11 | 中国科学院上海生命科学研究院 | 微小rna基因在系统性红斑狼疮疾病诊断和治疗中的作用 |
| CA2698771A1 (en) * | 2007-09-06 | 2009-03-12 | The Ohio State University Research Foundation | Microrna signatures in human ovarian cancer |
| EP2198050A1 (en) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Micrornas differentially expressed in cervical cancer and uses thereof |
| WO2009044895A1 (ja) * | 2007-10-03 | 2009-04-09 | Kyowa Hakko Kirin Co., Ltd. | 標的遺伝子の発現を抑制する組成物 |
| WO2009044899A1 (ja) * | 2007-10-03 | 2009-04-09 | Kyowa Hakko Kirin Co., Ltd. | 細胞の増殖を制御する核酸 |
| EA019939B1 (ru) | 2007-10-04 | 2014-07-30 | Сантарис Фарма А/С | МОДИФИЦИРОВАННЫЙ ОЛИГОМЕР ДЛЯ УМЕНЬШЕНИЯ КОЛИЧЕСТВА микроРНК В КЛЕТКЕ |
| CN101861401B (zh) * | 2007-10-11 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于诊断和治疗食管腺癌的方法和组合物 |
| US20090186015A1 (en) * | 2007-10-18 | 2009-07-23 | Latham Gary J | Micrornas differentially expressed in lung diseases and uses thereof |
| JP2011504093A (ja) | 2007-10-26 | 2011-02-03 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 脆弱性ヒスチジン三連構造(fhit)相互作用を同定するための方法およびその使用 |
| WO2009058907A2 (en) | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
| AU2008324814B2 (en) * | 2007-11-05 | 2013-05-16 | Solventum Intellectual Properties Company | Identification of tissue for debridement |
| MX2010005166A (es) * | 2007-11-09 | 2010-10-07 | Univ Texas | Micro arn de la familia mir-15 que modulan la sobrevivencia de cardiomiocitos y reparacion cardiaca. |
| ITRM20070595A1 (it) * | 2007-11-15 | 2009-05-16 | Univ Roma | Mirna e sirna e loro uso in terapia |
| WO2009066967A2 (en) * | 2007-11-23 | 2009-05-28 | Panagene Inc. | Microrna antisense pnas, compositions comprising the same, and methods for using and evaluating the same |
| EP2225396A4 (en) * | 2007-11-30 | 2011-03-02 | Univ Ohio State Res Found | PROFILING AND SCREENING OF MICRO-RNA EXPRESSION IN PERIPHERAL BLOOD IN LUNG CANCER |
| US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| WO2009086156A2 (en) * | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
| KR101325186B1 (ko) | 2008-01-23 | 2013-11-07 | (주)바이오니아 | 이중가닥 miRNA를 유효성분으로 포함하는 항암제 |
| JP5116026B2 (ja) | 2008-01-23 | 2013-01-09 | 富士フイルム株式会社 | 癌の検出方法および癌抑制剤 |
| CA2708661A1 (en) | 2008-01-27 | 2009-07-30 | Rosetta Genomics Ltd. | Methods and compositions for diagnosing complications of pregnancy |
| WO2009100430A2 (en) * | 2008-02-08 | 2009-08-13 | Asuragen, Inc | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
| EP3112477A1 (en) * | 2008-02-28 | 2017-01-04 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of prostate related disorders |
| CN102015027A (zh) * | 2008-02-28 | 2011-04-13 | 俄亥俄州立大学研究基金会 | 与人慢性淋巴细胞性白血病(ccl)相关的微rna特征和其用途 |
| US20110034538A1 (en) * | 2008-02-28 | 2011-02-10 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer |
| US8361980B2 (en) | 2008-03-07 | 2013-01-29 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microRNA related diseases |
| CN102036689B (zh) | 2008-03-17 | 2014-08-06 | 得克萨斯系统大学董事会 | 神经肌肉突触维持和再生中涉及的微小rna的鉴定 |
| EP2271370A4 (en) * | 2008-03-24 | 2011-11-02 | Univ New York | COMPOSITIONS AND METHODS OF DIAGNOSIS AND TREATMENT OF MELANOMA |
| EP2271757A2 (en) * | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Compositions and methods related to mir-16 and therapy of prostate cancer |
| US8741861B2 (en) * | 2008-03-27 | 2014-06-03 | Vascular Biosciences | Methods of novel therapeutic candidate identification through gene expression analysis in vascular-related diseases |
| WO2009126650A2 (en) * | 2008-04-07 | 2009-10-15 | Cornell Research Foundation, Inc. | Inhibition of angiognesis |
| WO2009126726A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
| WO2009137660A2 (en) * | 2008-05-07 | 2009-11-12 | Abraxis Bioscience, Llc | Enhancement of drug therapy by mirna |
| EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| WO2009137801A2 (en) * | 2008-05-08 | 2009-11-12 | The Trustees Of Columbia University In The City Of New York | Inhibitory rnas that regulate hematopoietic cells |
| WO2009147658A2 (en) * | 2008-06-02 | 2009-12-10 | New York University | Compositions and methods for diagnosis, prognosis and treatment of mesothelioma |
| WO2009149318A2 (en) * | 2008-06-05 | 2009-12-10 | Research Foundation Of State University Of New York | Mirnas as therapeutic targets in cancer |
| WO2009149418A2 (en) * | 2008-06-06 | 2009-12-10 | Asuragen, Inc. | Novel compositions for the in vivo delivery of rnai agents |
| US8247388B2 (en) * | 2008-06-06 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Role of miRNA in T cell leukemia |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| US8252534B2 (en) * | 2008-06-12 | 2012-08-28 | City Of Hope | Micro RNAs and their methods of use for the treatment and diagnosis of schizophrenia and schizophrenia spectrum disorders |
| WO2009153774A2 (en) * | 2008-06-17 | 2009-12-23 | Rosetta Genomics Ltd. | Compositions and methods for prognosis of ovarian cancer |
| WO2009153775A2 (en) * | 2008-06-17 | 2009-12-23 | Rosetta Genomics Ltd. | Methods for distinguishing between specific types of lung cancers |
| JP2011525799A (ja) | 2008-06-27 | 2011-09-29 | ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ | 抗ウイルス療法の応答の予測 |
| CN106995819B (zh) * | 2008-07-01 | 2020-10-20 | 孟山都技术公司 | 用于调控靶基因表达的重组dna构建体和方法 |
| WO2010001632A1 (ja) * | 2008-07-03 | 2010-01-07 | 国立大学法人神戸大学 | 関節リウマチ関連マイクロrna |
| WO2010012667A1 (en) | 2008-08-01 | 2010-02-04 | Santaris Pharma A/S | Micro-rna mediated modulation of colony stimulating factors |
| KR101042052B1 (ko) * | 2008-08-05 | 2011-06-16 | 사회복지법인 삼성생명공익재단 | 항-microRNA를 포함하는 고형암 예방 또는 치료용조성물 |
| WO2010017551A2 (en) * | 2008-08-08 | 2010-02-11 | The General Hospital Corporation | Method for mir-125a in promoting hematopoietic stem cell self renewal and expansion |
| WO2010019446A1 (en) * | 2008-08-09 | 2010-02-18 | University Of Iowa Research Foundation | Nucleic acid aptamers |
| WO2010019574A1 (en) * | 2008-08-11 | 2010-02-18 | The Board Of Regents Of The University Of Texas System | A micro-rna that promotes vascular integrity and uses thereof |
| JP2012500389A (ja) * | 2008-08-12 | 2012-01-05 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 多発性脊髄腫の診断、予後および治療のためのマイクロrnaに基づく組成物および方法 |
| WO2010019874A1 (en) * | 2008-08-15 | 2010-02-18 | The Translational Genomics Research Institute (Tgen) | Methods of predicting the risk of recurrence of cancer |
| AU2009283906A1 (en) * | 2008-08-19 | 2010-02-25 | Maine Institute For Human Genetics And Health | Micro RNA and Neurofibromatosis Type 1 in diagnosis and therapy |
| US9347089B2 (en) | 2008-09-19 | 2016-05-24 | Children's Medical Center Corporation | Therapeutic and diagnostic strategies |
| EP4219760A3 (en) * | 2008-11-10 | 2023-09-06 | Battelle Memorial Institute | Methods, compositions, and devices utilizing microrna to determine physiological conditions |
| US20100179213A1 (en) * | 2008-11-11 | 2010-07-15 | Mirna Therapeutics, Inc. | Methods and Compositions Involving miRNAs In Cancer Stem Cells |
| EP2370091B1 (en) | 2008-12-05 | 2017-04-12 | Whitehead Institute for Biomedical Research | Compositions and methods relating to mir-31 |
| US8734759B2 (en) | 2008-12-05 | 2014-05-27 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and treating motor neuron diseases |
| EP2208785A1 (en) | 2009-01-15 | 2010-07-21 | Newbiotechnic, S.A. | Methods and kits to generate miRNA- and smallRNA-expressing vectors, and its application to develop lentiviral expression libraries |
| JP2012515532A (ja) | 2009-01-20 | 2012-07-12 | ラモット アット テル アビブ ユニバーシティ, リミテッド | Mir−21プロモーター駆動性標的がん治療 |
| WO2010088668A2 (en) | 2009-02-02 | 2010-08-05 | Cepheid | Methods of detecting sepsis |
| MX2011008190A (es) * | 2009-02-04 | 2011-10-06 | Univ Texas | Direccionamiento dual de mir-208 y mir-499 en el tratamiento de trastornos cardiacos. |
| EP2218458A1 (en) * | 2009-02-13 | 2010-08-18 | Fondazione Telethon | Molecules able to modulate the expression of at least a gene involved in degradative pathways and uses thereof |
| US20100311815A1 (en) * | 2009-02-23 | 2010-12-09 | The Regents Of The University Of Michigan | Mir-101 cancer markers |
| EP2401405A4 (en) * | 2009-02-26 | 2013-10-16 | Univ Ohio State Res Found | MICRO-RNAS FOR NON-SMOKERS AND RELATED MATERIALS AND METHODS |
| WO2010107397A1 (en) * | 2009-03-19 | 2010-09-23 | Agency For Science, Technology And Research | Modulators of apoptosis and the uses thereof |
| WO2010108192A1 (en) * | 2009-03-20 | 2010-09-23 | The Research Foundation Of State University Of New York | Mirnas as therapeutic targets in cancer |
| JP2012522508A (ja) | 2009-03-31 | 2012-09-27 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロrna |
| WO2010120969A1 (en) * | 2009-04-15 | 2010-10-21 | Board Of Regents, The University Of Texas System | Targeting of the mir-30 family and let-7 family as a treatment for heart disease |
| ES2599979T3 (es) | 2009-04-24 | 2017-02-06 | Roche Innovation Center Copenhagen A/S | Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón |
| JP5871791B2 (ja) * | 2009-04-29 | 2016-03-01 | アカデミス・メディス・セントルム・ベイ・デ・ウニフェルジテイト・ファン・アムステルダムAcademisch Medisch Centrum Bij De Universiteit Van Amsterdam | 心不全または心不全の危険性を中和、予防および/または決定する手段および方法 |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US20120264626A1 (en) * | 2009-05-08 | 2012-10-18 | The Ohio State University Research Foundation | MicroRNA Expression Profiling and Targeting in Chronic Obstructive Pulmonary Disease (COPD) Lung Tissue and Methods of Use Thereof |
| WO2010129919A1 (en) * | 2009-05-08 | 2010-11-11 | Research Development Foundation | Mirna expression in allergic disease |
| EP2430579A2 (en) * | 2009-05-11 | 2012-03-21 | Koninklijke Philips Electronics N.V. | Device and method for comparing molecular signatures |
| US9072765B2 (en) | 2009-05-20 | 2015-07-07 | Board Of Regents, The University Of Texas System | Identification of micro-RNAs involved in post-myocardial infarction remodeling and heart failure |
| WO2010133970A1 (en) | 2009-05-20 | 2010-11-25 | Eth Zurich | Targeting micrornas for metabolic disorders |
| EP2435583B1 (en) | 2009-05-25 | 2014-07-09 | Università degli Studi di Roma "La Sapienza" | miR-31 IN DUCHENNE MUSCULAR DYSTROPHY THERAPY |
| CA2762303A1 (en) * | 2009-05-25 | 2010-12-02 | Carola Ponzetto | Differentiation therapy for sarcomas |
| CN102666855A (zh) * | 2009-06-10 | 2012-09-12 | 脑干生物技术有限公司 | 用于多能性基质细胞的神经元分化的方法、系统和组合物 |
| US20100322909A1 (en) | 2009-06-17 | 2010-12-23 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Th1-associated micrornas and their use for tumor immunotherapy |
| US8962583B2 (en) | 2009-06-25 | 2015-02-24 | The Brigham And Women's Hospital, Inc. | Treatment of inflammatory diseases using miR-124 |
| WO2011012136A1 (en) * | 2009-07-28 | 2011-02-03 | Exiqon A/S | A method for classifying a human cell sample as cancerous |
| FR2948687B1 (fr) * | 2009-07-29 | 2015-09-04 | Centre Nat Rech Scient | Utilisation de microarn pour le traitement de pathologies respiratoires chroniques |
| EP2460005A4 (en) * | 2009-07-31 | 2012-11-21 | Translational Genomics Res Inst | METHOD FOR ASSESSING A CANCER PROGRESSION RISK |
| KR101802536B1 (ko) * | 2009-08-05 | 2017-11-28 | 큐알엔에이, 인크. | 인슐린 유전자 (ins)에 대한 자연 안티센스 전사체의 저해에 의한 인슐린 유전자 (ins) 관련된 질환의 치료 |
| WO2011017408A1 (en) * | 2009-08-05 | 2011-02-10 | The Ohio State University Research Foundation | Anti-mir-1 therapy for wound healing |
| EP2283846A1 (en) | 2009-08-12 | 2011-02-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | miRNA compounds for treatment of prostate carcinoma |
| WO2011034811A1 (en) | 2009-09-17 | 2011-03-24 | Sigma-Aldrich Co. | Short rna mimetics |
| WO2011047147A1 (en) * | 2009-10-14 | 2011-04-21 | Baylor College Of Medicine | Microrna mirna-31 as a therapeutic approach for the treatment of cancer |
| WO2011059752A1 (en) * | 2009-10-28 | 2011-05-19 | Board Of Regents Of The University Of Texas System | Methods and compositions for anti-egfr treatment |
| EP3118334A1 (en) | 2009-11-04 | 2017-01-18 | DiamiR, LLC | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| EP2504014A4 (en) * | 2009-11-24 | 2013-04-17 | Univ Western Australia | MODULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS |
| EP2327783A1 (en) * | 2009-11-27 | 2011-06-01 | Universitätsklinikum Freiburg | Pharmaceutical composition comprising miRNA-100 and its use in the modulation of blood vessel growth |
| US8354520B2 (en) * | 2009-12-10 | 2013-01-15 | Kaohsiung Medical University | Composition and method for treating atherosclerosis, method for determining if a subject has atherosclerosis and method of screening an anti-atherosclerotic drug |
| US20120315640A1 (en) | 2009-12-21 | 2012-12-13 | Hidetoshi Tahara | Senescence marker, method for evaluating senescence inhibitor, and cancer inhibitor |
| EP2518144B1 (en) * | 2009-12-21 | 2015-08-05 | Hiroshima University | Aging marker, method for evaluating aging inhibitor, and cancer inhibitor |
| WO2011084815A1 (en) * | 2009-12-21 | 2011-07-14 | Board Of Trustees Of Southern Illinois University | Inhibition of ubc9-mediated cancer cell invasion and metastasis |
| WO2011079299A1 (en) * | 2009-12-23 | 2011-06-30 | The George Washington University | Compositions and methods for identifying autism spectrum disorders |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| WO2011088309A1 (en) | 2010-01-14 | 2011-07-21 | Regulus Therapeutics Inc. | Microrna compositions and methods |
| WO2011091209A1 (en) * | 2010-01-21 | 2011-07-28 | North Carolina State University | Small molecule modifiers of microrna mir-122 |
| JP2011188849A (ja) * | 2010-02-18 | 2011-09-29 | Okayama Univ | 抗腫瘍効果を有するmiR−7発現プラスミド |
| US8841269B2 (en) * | 2010-02-23 | 2014-09-23 | Creighton University | Polynucleotides for use in treating and diagnosing cancers |
| EP3214174B1 (en) * | 2010-03-04 | 2019-10-16 | InteRNA Technologies B.V. | A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt |
| WO2011111715A1 (ja) * | 2010-03-09 | 2011-09-15 | 協和発酵キリン株式会社 | 細胞周期を制御する核酸 |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| RS54482B1 (sr) | 2010-04-05 | 2016-06-30 | Prognosys Biosciences, Inc. | Biološka testiranja sa prostornim kodiranjem |
| EP3502254B1 (en) | 2010-04-23 | 2024-11-06 | Cold Spring Harbor Laboratory | Novel structurally designed shrnas |
| US20140086828A1 (en) * | 2010-05-28 | 2014-03-27 | Aaron E. Foster | Modified gold nanoparticles for therapy |
| JP6109069B2 (ja) | 2010-06-04 | 2017-04-05 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | miR−378による代謝調節 |
| ES2459143T3 (es) * | 2010-06-09 | 2014-05-08 | Chanel Parfums Beauté | Inhibidores de varios microARN para usar en la prevención y/o atenuación del envejecimiento cutáneo y/o para hidratar la piel |
| EP2591106A1 (en) * | 2010-07-06 | 2013-05-15 | InteRNA Technologies B.V. | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| WO2012008302A1 (ja) | 2010-07-12 | 2012-01-19 | 国立大学法人鳥取大学 | miRNA導入による新規hiPSC作製法 |
| US8580513B2 (en) * | 2010-07-20 | 2013-11-12 | Trustees Of Dartmouth College | Methods for determining response to neoadjuvant therapy and survival using MicroRNA-10b |
| US8815826B2 (en) | 2010-07-23 | 2014-08-26 | Regulus Therapeutics, Inc. | Targeting microRNAs for the treatment of fibrosis |
| US10385314B2 (en) | 2010-08-16 | 2019-08-20 | Exostem Biotec Ltd. | Methods of generating oligodendrocytes and cell populations comprising same |
| EP2606123A4 (en) | 2010-08-16 | 2014-01-15 | Brainstem Biotec Ltd | METHOD OF GENERATING OLIGOD DROCYTES AND CELL POPULATIONS THEREWITH |
| CN106153944B (zh) * | 2010-08-17 | 2018-09-28 | 日内瓦大学 | 肺癌和结直肠癌中的bard1同工型、其检测方法及其应用 |
| US8642342B2 (en) | 2010-08-19 | 2014-02-04 | Regents Of The University Of Michigan | Methods for regulating neural differentiation |
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| US9006195B2 (en) * | 2010-09-13 | 2015-04-14 | California Institute Of Technology | Regulation of hematopoietic stem cell functions through microRNAs |
| CN103221542A (zh) * | 2010-09-27 | 2013-07-24 | 萨班哲大学 | miRNA用于诊断、预防、治疗和追踪涉及巨自噬异常的疾病的用途 |
| WO2012041959A1 (en) | 2010-09-30 | 2012-04-05 | University Of Zurich | Treatment of b-cell lymphoma with microrna |
| JPWO2012063894A1 (ja) | 2010-11-12 | 2014-05-12 | 国立大学法人愛媛大学 | マイクロrnaのアンチセンスオリゴヌクレオチドを含む組成物 |
| CA2816603A1 (en) * | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| BR112013011942A2 (pt) | 2010-11-15 | 2016-11-01 | Univ Michigan | formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida. |
| AU2011329772B2 (en) | 2010-11-17 | 2017-05-04 | Interpace Diagnostics, Llc | miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms |
| EP2942403B1 (en) * | 2010-12-01 | 2017-04-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the outcome of a cancer by analysing mirna expression |
| US11344505B1 (en) | 2010-12-01 | 2022-05-31 | Gowey Research Group, Pllc | Herbal formulations of carnivorous plants and methods for treating inflammation |
| US12318420B2 (en) | 2010-12-01 | 2025-06-03 | Gowey Research Group, Pllc | Herbal formulations of carnivorous plants and methods for treating inflammation |
| US10758578B2 (en) | 2010-12-01 | 2020-09-01 | Gowey Research Group PLLC | Herbal formulations of carnivorous plants and methods for treating inflammation |
| US11414663B2 (en) | 2010-12-01 | 2022-08-16 | Gowey Research Group, Pllc | Micro-RNA profiling, compositions, and methods of treating diseases |
| US10744151B1 (en) * | 2010-12-01 | 2020-08-18 | Gowey Research Group PLLC | Micro-RNA profiling, compositions, and methods of treating diseases |
| WO2012082821A2 (en) * | 2010-12-15 | 2012-06-21 | Medimmune, Llc | Melanoma treatments |
| AU2011343720A1 (en) | 2010-12-15 | 2013-04-11 | Miragen Therapeutics | MicroRNA inhibitors comprising locked nucleotides |
| EP2654801B1 (en) | 2010-12-20 | 2017-11-01 | Agency For Science, Technology And Research | Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138 |
| EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
| CN105969773A (zh) | 2011-02-03 | 2016-09-28 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| EP3178932A1 (en) | 2011-02-03 | 2017-06-14 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-34 |
| SMT201900474T1 (it) * | 2011-02-07 | 2019-09-09 | Gabriella Sozzi | Microrna biomarcatori per identificare il rischio di e/o per diagnosticare tumore ai polmoni |
| EP2683387A4 (en) | 2011-03-07 | 2014-09-03 | Univ Ohio State | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| ES2855577T3 (es) * | 2011-03-30 | 2021-09-23 | Transine Therapeutics Ltd | Molécula de ácido nucleico funcional y uso de la misma |
| WO2012135817A2 (en) * | 2011-03-31 | 2012-10-04 | University Of Houston | Microrna 130a,b as a tumor suppressor and sensitizing agent for chemotherapy |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| WO2012140234A1 (en) | 2011-04-13 | 2012-10-18 | Vib Vzw | Modulation of mirna in diseases with aberrant angiogenesis |
| AU2012245580B2 (en) | 2011-04-18 | 2017-07-20 | Diamir, Llc | miRNA-based universal screening test (UST) |
| WO2012145743A1 (en) * | 2011-04-22 | 2012-10-26 | University Of Houston | Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy |
| HRP20170557T2 (hr) | 2011-04-25 | 2020-02-21 | Regulus Therapeutics Inc. | Mikrorna spojevi i postupci za modulaciju aktivnosti mir-21 |
| EE201100037A (et) * | 2011-05-16 | 2012-12-17 | Tartu Ülikool | MikroRNAde kasutamine biomarkeritena ja sihtmrkidena raku proliferatiivsete omaduste m?jutamiseks ja meetod ning komplekt nende ekspressioonitaseme tuvastamiseks |
| EP2723890B1 (en) * | 2011-06-27 | 2019-10-09 | Galderma Research & Development | New th17 differentiation markers for acne and uses thereof |
| JP6279467B2 (ja) | 2011-06-27 | 2018-02-14 | ガルデルマ・リサーチ・アンド・デヴェロップメント | ざ瘡についての新規th17分化マーカーおよびその使用 |
| US8747860B2 (en) | 2011-07-06 | 2014-06-10 | Institute For Systems Biology | Methods and compositions to modulate antiviral and immune activity responses |
| US9160965B2 (en) | 2011-08-01 | 2015-10-13 | Thomson Licensing | Telepresence communications system and method |
| CN107115352B (zh) | 2011-08-04 | 2020-10-30 | 耶达研究及发展有限公司 | 微rna和包含微rna的组合物 |
| US8987224B2 (en) | 2011-08-05 | 2015-03-24 | Baylor College Of Medicine | MicroRNA-198 as a tumor suppressor in pancreatic cancer |
| AU2012296977A1 (en) | 2011-08-12 | 2014-01-23 | Westfaelische Wilhelms-Universitaet Muenster | Novel compounds for the treatment of inflammatory bowel disease |
| WO2013032962A2 (en) * | 2011-08-28 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease |
| US9434944B2 (en) | 2011-08-31 | 2016-09-06 | University Of Zurich | Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| EP2755663A4 (en) | 2011-09-13 | 2015-10-07 | Ottawa Hospital Res Inst | MicroRNA Inhibitors |
| CA2850223A1 (en) | 2011-10-06 | 2013-04-11 | Eva Van Rooij | Control of whole body energy homeostasis by microrna regulation |
| HK1197273A1 (en) | 2011-10-14 | 2015-01-09 | The Ohio State University | Methods and materials related to ovarian cancer |
| EP2584040A1 (en) | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
| JP6137484B2 (ja) * | 2011-11-02 | 2017-05-31 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| US20140323551A1 (en) * | 2011-11-30 | 2014-10-30 | Cedars-Sinai Medical Center | Targeting micrornas mir-409-5p, mir-379 and mir-154* to treat prostate cancer bone metastasis and drug resistant lung cancer |
| AU2012346899A1 (en) * | 2011-12-01 | 2014-06-19 | Cincinnati Children's Hospital Medical Center | Materials and methods related to NSAID chemoprevention in colorectal cancer |
| US20140351963A1 (en) * | 2011-12-10 | 2014-11-27 | Ohio State Innovation Foundation | MiRNAs Useful to Reduce Lung Cancer Tumorigenesis and Chemotherapy Resistance and Related Compositions and Methods |
| US9481885B2 (en) | 2011-12-13 | 2016-11-01 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| US10034902B2 (en) | 2012-02-22 | 2018-07-31 | Exostem Biotec Ltd. | MicroRNAs for the generation of astrocytes |
| WO2013124816A2 (en) | 2012-02-22 | 2013-08-29 | Brainstem Biotec Ltd. | Generation of neural stem cells and motor neurons |
| BR112014021401B1 (pt) | 2012-03-09 | 2022-10-11 | Interdigital Madison Patent Holdings | Método para processar um comando de transporte em um controlador de conteúdo local e método para processar um primeiro comando de transporte em um controlador de conteúdo local para controlar conteúdo compartilhado |
| PE20142404A1 (es) | 2012-04-25 | 2015-02-02 | Regulus Therapeutics Inc | Compuestos de microarn y metodos de modulacion de la actividad de mir-21 |
| WO2013166240A1 (en) * | 2012-05-02 | 2013-11-07 | The Board Of Regents Of The University Of Texas System | Micro-rnas involved in macular degeneration |
| WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
| EP2857513A4 (en) | 2012-05-26 | 2016-05-25 | Bonac Corp | Single-stranded nucleic acid molecule controlling the expression of a gene transporter |
| US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
| HK1209781A1 (en) | 2012-06-21 | 2016-04-08 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| WO2014007120A1 (ja) * | 2012-07-06 | 2014-01-09 | タカラバイオ株式会社 | アデノ随伴ウイルスベクターの産生細胞 |
| SG11201500615WA (en) | 2012-07-27 | 2015-04-29 | Agency Science Tech & Res | Method of promoting wound healing |
| WO2014020608A1 (en) | 2012-07-31 | 2014-02-06 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and treating motor neuron diseases |
| ES2534210T3 (es) * | 2012-08-29 | 2015-04-20 | Chanel Parfums Beauté | Inhibidores de micro-ARN para uso para prevenir y/o atenuar el envejecimiento cutáneo |
| EP2702998A1 (en) | 2012-08-31 | 2014-03-05 | IMBA-Institut für Molekulare Biotechnologie GmbH | Therapeutic and diagnostic miRNA regulator in kidney disease |
| US20150344961A1 (en) * | 2012-09-11 | 2015-12-03 | New York University | Sera Based miRNAs as Non-Invasive Biomarkers in Melanoma |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| EP3901280B1 (en) | 2012-10-17 | 2025-03-12 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| WO2014071205A1 (en) * | 2012-11-02 | 2014-05-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies |
| US9340787B2 (en) * | 2012-11-15 | 2016-05-17 | Yale University | Compositions and methods of using micro RNAs |
| WO2014099999A1 (en) * | 2012-12-18 | 2014-06-26 | Sanford-Burnham Medical Research Institute | Methods for improving cardiac contractility |
| DK2963125T3 (da) * | 2013-02-15 | 2020-10-12 | Univ Nat Corp Tokyo Medical & Dental | Terapeutisk middel til behandling af en cancer, hvor NRF2 er stabiliseret |
| WO2014164753A1 (en) * | 2013-03-11 | 2014-10-09 | Emory University | Methods and compositions for managing vascular conditions |
| US9006200B2 (en) * | 2013-03-13 | 2015-04-14 | Asbestos Diseases Research Foundation | MicroRNA-based approach to treating malignant pleural mesothelioma |
| AU2014228166A1 (en) | 2013-03-15 | 2015-09-24 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing micrornas and EGFR-TKI inhibitors |
| WO2014140856A2 (en) | 2013-03-15 | 2014-09-18 | Graham Lord | Mir-142 and antagonists thereof for treating disease |
| CA2902623A1 (en) | 2013-03-15 | 2014-09-25 | MiRagen Therapeutics, Inc. | Locked nucleic acid inhibitor of mir-145 and uses thereof |
| WO2014152243A1 (en) * | 2013-03-15 | 2014-09-25 | Albert Einstein College Of Medicine Of Yeshiva University | Panel of microrna biomarkers in healthy aging |
| US9756288B2 (en) | 2013-04-10 | 2017-09-05 | Thomson Licensing | Tiering and manipulation of peer's heads in a telepresence system |
| JP2016169158A (ja) * | 2013-06-14 | 2016-09-23 | 北海道公立大学法人 札幌医科大学 | 大腸癌を治療および/または診断するための組成物ならびにその利用 |
| GB201310755D0 (en) * | 2013-06-17 | 2013-07-31 | Ucl Business Plc | Therapy |
| CN105493422A (zh) | 2013-06-20 | 2016-04-13 | 汤姆逊许可公司 | 用于辅助内容的分布式播放的同步的系统和方法 |
| MX2015017749A (es) | 2013-06-24 | 2016-04-04 | Mirna Therapeutics Inc | Biomarcadores de actividad mir-34. |
| LT3013983T (lt) | 2013-06-25 | 2023-05-10 | Prognosys Biosciences, Inc. | Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį |
| US9862943B1 (en) * | 2013-06-27 | 2018-01-09 | California Institute Of Technology | Long noncoding RNAs and cell reprogramming and differentiation |
| WO2015020122A1 (ja) * | 2013-08-08 | 2015-02-12 | 国立大学法人 大阪大学 | 尿路上皮癌の診断または治療剤 |
| KR101566586B1 (ko) * | 2013-08-21 | 2015-11-16 | 서울대학교산학협력단 | miRNA를 표적으로 하는 뇌전증 또는 발작 관련 질환의 예방 또는 치료용 약학 조성물 및 방법 |
| EP3049522A2 (en) * | 2013-09-26 | 2016-08-03 | Friedrich Miescher Institute for Biomedical Research | Tools and methods using mirna 182, 96 and/or 183 for treating pathologies |
| US20150089870A1 (en) * | 2013-10-01 | 2015-04-02 | Wayne State University | Population control of invasive plant species and restoration of native plant communities |
| KR101598070B1 (ko) * | 2013-10-17 | 2016-02-26 | 한국과학기술연구원 | 마약 중독 예방 및 치료용 약제학적 조성물 |
| WO2015066034A1 (en) | 2013-10-28 | 2015-05-07 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for modulating neuronal excitability and motor behavior |
| KR101559131B1 (ko) * | 2013-11-18 | 2015-10-07 | 한국원자력의학원 | miRNA를 포함하는 방사선 민감성 증진용 조성물 |
| AU2014348273A1 (en) | 2013-11-18 | 2016-06-09 | Diamir, Llc | Methods of using mIRNAs from bodily fluids for detection and monitoring of Parkinson's disease (PD) |
| EP3084008B1 (en) | 2013-12-17 | 2018-07-18 | Csir | A method for identification of anti-hiv human mirna mimics and mirna inhibitors and anti-hiv pharmaceutical compounds |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックmiRNAおよびその用途 |
| RU2697094C2 (ru) * | 2013-12-27 | 2019-08-12 | Бонак Корпорейшн | ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ |
| JP6492014B2 (ja) * | 2013-12-27 | 2019-03-27 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型miRNAおよびその用途 |
| US10125365B2 (en) | 2014-02-05 | 2018-11-13 | Yeda Research And Development Co. Ltd. | Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
| WO2015133637A1 (ja) * | 2014-03-07 | 2015-09-11 | 国立大学法人京都大学 | マイクロrna封入ナノ粒子及びその医薬用途 |
| US20160136181A1 (en) | 2014-04-01 | 2016-05-19 | Mirna Therapeutics, Inc | Microrna dosing regimens |
| ES2877689T3 (es) * | 2014-05-02 | 2021-11-17 | Univ Heidelberg Ruprecht Karls | miARN circulantes como marcador de detección temprana y marcador pronóstico |
| CN113444783B (zh) * | 2014-06-26 | 2024-04-09 | 西奈山伊坎医学院 | 通过分析预示性基因集诊断亚临床和临床的急性排异的方法 |
| JP6634372B2 (ja) * | 2014-07-15 | 2020-01-22 | 株式会社ミツバ | ブラシレスワイパモータ |
| LU92499B1 (en) | 2014-07-16 | 2016-01-18 | Univ Muenster Wilhelms | Mirna 320a as biomarker for inflammatory bowel disease |
| ES2558262B2 (es) | 2014-08-01 | 2016-07-14 | Universidad Católica De Valencia "San Vicente Mártir" | Método de diagnóstico de fibromialgia basado en microRNAs |
| BR112017001931A2 (pt) | 2014-08-07 | 2017-11-28 | Regulus Therapeutics Inc | direcionamento de micrornas para distúrbios metabólicos |
| US20170298352A1 (en) * | 2014-09-30 | 2017-10-19 | Research Institute at Nationwide Children's Hospit al | Compositions and methods for treating hepatic fibrosis |
| CA2971827A1 (en) * | 2014-12-27 | 2016-06-30 | Bonac Corporation | Naturally occuring mirna for controlling gene expression, and use of same |
| BR112017015618A2 (pt) | 2015-01-20 | 2018-04-10 | Miragen Therapeutics Inc | inibidores de mir-92 e usos destes. |
| GB201504772D0 (en) * | 2015-03-20 | 2015-05-06 | Univ Aston | Preeclampsia |
| US20180064748A1 (en) | 2015-03-27 | 2018-03-08 | Yeda Research And Development Co. Ltd. | Methods of treating motor neuron diseases |
| CN108064289A (zh) | 2015-03-27 | 2018-05-22 | 株式会社博纳克 | 具有递送功能和基因表达调控能力的单链核酸分子 |
| HK1250245A1 (zh) | 2015-04-10 | 2018-12-07 | Spatial Transcriptomics Ab | 生物样本的空间区别、多重核酸分析 |
| JPWO2016167366A1 (ja) * | 2015-04-17 | 2018-04-05 | 国立大学法人 東京大学 | 眼疾患治療剤 |
| WO2016183414A1 (en) * | 2015-05-14 | 2016-11-17 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing granulomatous diseases |
| WO2016190899A1 (en) * | 2015-05-23 | 2016-12-01 | Beem Alan M H | Pri-mirna libraries and methods for making and using pri-mirna libraries |
| IL316159A (en) | 2015-06-15 | 2024-12-01 | Mpeg La Llc | Defined Oligonucleotide Multimers and Methods for Manufacture Thereof |
| WO2017020009A1 (en) * | 2015-07-30 | 2017-02-02 | Regents Of The University Of Minnesota | Regulation of mesodermal specification |
| EP3334436A4 (en) * | 2015-08-13 | 2019-05-29 | SomaGenics Inc. | PROCESSES AND COMPOSITIONS OF SHORT-SMALL-HAIRPIN-RNAS AND MICRO-RNAS FOR WOUND HEALING |
| WO2017032776A1 (en) * | 2015-08-21 | 2017-03-02 | Universitätsklinikum Jena | Human micrornas for treatment of malignant tumours |
| CN108367020B (zh) * | 2015-09-28 | 2021-06-18 | 国立大学法人千叶大学 | 通过miR-200家族抑制来抑制肿瘤的方法 |
| WO2017058938A1 (en) | 2015-09-29 | 2017-04-06 | Research Institute At Nationwide Children's Hospital | Methods for detecting hepatic fibrosis and responsiveness to therapy |
| JP6666002B2 (ja) * | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Tdp−43プロテノパシーの予防又は治療用組成物 |
| CN108699603A (zh) * | 2015-12-10 | 2018-10-23 | 维也纳自然资源与生命科学大学 | 用于诊断和治疗骨折和骨病的组合物和方法 |
| EP3181698A1 (en) | 2015-12-16 | 2017-06-21 | European Molecular Biology Laboratory (EMBL) | Microrna mir-142 as stem cell marker |
| US11041006B2 (en) | 2015-12-28 | 2021-06-22 | Riken | Compositions for use in recovering or ameliorating deterioration of physiological functions due to aging |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| CN105543225A (zh) * | 2016-01-07 | 2016-05-04 | 华东师范大学 | miR143及其诱导物LTA在制备抑制痤疮炎症药物中的应用 |
| US10771508B2 (en) | 2016-01-19 | 2020-09-08 | Nadejda Sarmova | Systems and methods for establishing a virtual shared experience for media playback |
| US11364258B2 (en) | 2016-03-04 | 2022-06-21 | Rhode Island Hospital | Methods for treating chondrosarcoma using microrna(miR) |
| WO2017165458A1 (en) | 2016-03-21 | 2017-09-28 | Diamir, Llc | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
| EP3444345B1 (en) * | 2016-04-14 | 2024-07-10 | e-NA Biotec Inc. | microRNA-143 DERIVATIVE |
| WO2017192601A1 (en) * | 2016-05-02 | 2017-11-09 | University Of Massachusetts | T cell differentiation and function regulation |
| US11013752B2 (en) * | 2016-06-03 | 2021-05-25 | Hough Ear Institute | Combination therapies for inner ear sensory hair cell regeneration/replacement |
| JP6842779B2 (ja) * | 2016-10-31 | 2021-03-17 | 国立大学法人岐阜大学 | 二本鎖核酸分子、およびその用途 |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| CN107058470B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒 |
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| CN107223203B (zh) | 2017-04-19 | 2018-07-06 | 深圳市汇顶科技股份有限公司 | 光强检测方法、装置及智能终端 |
| JP7083818B2 (ja) * | 2017-04-28 | 2022-06-13 | 一丸ファルコス株式会社 | プラセンタ抽出物 |
| WO2018204829A1 (en) * | 2017-05-04 | 2018-11-08 | University Of Maryland, Baltimore | Methods for preventing neural tube defects in diabetic pregnancy |
| EP3624825A4 (en) | 2017-05-19 | 2021-03-10 | Georgia State University Research Foundation, Inc. | RECOMBINANT ONCOLYTIC VIRUS |
| KR102110103B1 (ko) * | 2017-06-16 | 2020-05-13 | (주)프로스테믹스 | 암의 예방 또는 치료용 약학적 조성물 |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| WO2019116234A1 (en) | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
| SG11202008925VA (en) * | 2018-03-14 | 2020-10-29 | Beth Israel Deaconess Medical Ct Inc | Inhibitors of micro-rna 22 |
| US10716866B2 (en) | 2018-03-29 | 2020-07-21 | Generoath Co., Ltd | Pharmaceutical composition comprising AIMP2-DX2 for preventing or treating neuronal diseases and use thereof |
| WO2019195765A1 (en) * | 2018-04-06 | 2019-10-10 | University Of Massachusetts | Mlk-regulated micrornas in angiogenesis and tumor development |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| KR102115960B1 (ko) * | 2018-11-28 | 2020-05-27 | 송미연 | 인간 중간엽 줄기세포를 갑상선 호르몬 분비세포로 분화 방법 |
| EP4567127A3 (en) | 2018-12-10 | 2025-09-03 | 10x Genomics, Inc. | Methods for determining a location of a biological analyte in a biological sample |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| CA3139919A1 (en) * | 2019-03-11 | 2020-09-17 | Ochsner Health System | Microrna regulatory network as biomarkers of seizure in patients with spontaneous intracerebral hemorrhage |
| KR102248420B1 (ko) * | 2019-03-15 | 2021-05-06 | 주식회사 제너로스 | miR-142-3p의 표적 서열을 포함하는 재조합 벡터 |
| US20220251552A1 (en) * | 2019-03-25 | 2022-08-11 | The Trustees Of The University Of Pennsylvania | Regenerative Therapy Based on miRNA-302 Mimics for Enhancing Host Recovery from Pneumonia Caused by Streptococcus pneumoniae |
| WO2020212586A1 (en) * | 2019-04-18 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment and prognosis of cancer |
| CA3137897A1 (en) * | 2019-04-24 | 2020-10-29 | Nevada Research & Innovation Corporation | Methods and compositions of mir-10 mimics and targets thereof |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
| US10844380B1 (en) | 2019-06-17 | 2020-11-24 | Biorchestra Co., Ltd. | Uses for prevention or treatment of brain diseases using microrna |
| CN110551809A (zh) * | 2019-08-21 | 2019-12-10 | 昆明医科大学第一附属医院 | miR-124在脊髓损伤修复中的用途 |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| EP4055185A1 (en) | 2019-11-08 | 2022-09-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| EP3891300B1 (en) | 2019-12-23 | 2023-03-29 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| AU2020415455A1 (en) * | 2019-12-23 | 2022-07-14 | University Of Massachusetts | Oligonucleotides for tissue specific gene expression modulation |
| US12241890B2 (en) | 2019-12-23 | 2025-03-04 | 10X Genomics, Inc. | Methods for generating barcoded nucleic acid molecules using fixed cells |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
| US12399123B1 (en) | 2020-02-14 | 2025-08-26 | 10X Genomics, Inc. | Spatial targeting of analytes |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| EP4093870A4 (en) * | 2020-03-13 | 2024-01-10 | Duke University | COMPOSITIONS FOR TREATING NASH AND RELATED DISEASES AND METHODS OF USING THE SAME |
| EP4242325B1 (en) | 2020-04-22 | 2025-01-29 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| WO2021236625A1 (en) | 2020-05-19 | 2021-11-25 | 10X Genomics, Inc. | Electrophoresis cassettes and instrumentation |
| EP4553168A3 (en) | 2020-05-22 | 2025-08-27 | 10x Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| CN116249785A (zh) | 2020-06-02 | 2023-06-09 | 10X基因组学有限公司 | 用于抗原-受体的空间转录组学 |
| US12265079B1 (en) | 2020-06-02 | 2025-04-01 | 10X Genomics, Inc. | Systems and methods for detecting analytes from captured single biological particles |
| WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| US12435363B1 (en) | 2020-06-10 | 2025-10-07 | 10X Genomics, Inc. | Materials and methods for spatial transcriptomics |
| EP4446430A3 (en) | 2020-06-10 | 2024-12-18 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| EP4172362B1 (en) | 2020-06-25 | 2024-09-18 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| CN112190592B (zh) * | 2020-08-25 | 2022-03-11 | 苏州市立医院(北区) | miRNA在制备防治骨关节炎药物的应用、miRNA高表达的外泌体和应用 |
| EP4491742A3 (en) | 2020-09-18 | 2025-05-21 | 10x Genomics, Inc. | Sample handling apparatus and image registration methods |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| WO2022076774A2 (en) * | 2020-10-08 | 2022-04-14 | The Trustees Of Columbia University In The City Of New York | Treatment and detection of liver fibrosis and liver disease using microrna |
| CN112375823B (zh) * | 2020-10-22 | 2022-09-16 | 上海交通大学医学院附属瑞金医院 | miRNA抑制剂在制备治疗和/或预防淋巴瘤的药物中的应用 |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| WO2022178218A1 (en) | 2021-02-19 | 2022-08-25 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
| EP4294571B8 (en) | 2021-02-19 | 2024-07-10 | 10X Genomics, Inc. | Method of using a modular assay support device |
| AU2022238446A1 (en) | 2021-03-18 | 2023-09-07 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
| WO2022221425A1 (en) | 2021-04-14 | 2022-10-20 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| EP4320271B1 (en) | 2021-05-06 | 2025-03-19 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| US20240301504A1 (en) * | 2021-06-22 | 2024-09-12 | The Curators Of The University Of Missouri | Multianalyte biomarkers for lung cancer |
| ES3011462T3 (en) | 2021-09-01 | 2025-04-07 | 10X Genomics Inc | Methods for blocking a capture probe on a spatial array |
| EP4419707A1 (en) | 2021-11-10 | 2024-08-28 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| WO2023122033A1 (en) | 2021-12-20 | 2023-06-29 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
| WO2023118546A2 (en) | 2021-12-23 | 2023-06-29 | Boehringer Ingelheim International Gmbh | METHODS AND MOLECULES FOR RNA INTERFERENCE (RNAi) |
| US11541116B1 (en) | 2022-01-07 | 2023-01-03 | Kojin Therapeutics, Inc. | Methods and compositions for inducing ferroptosis in vivo |
| WO2024108031A2 (en) * | 2022-11-16 | 2024-05-23 | University Of Notre Dame Du Lac | Mirna cocktail for treatment and prevention of fibrosis |
| KR102583230B1 (ko) * | 2023-03-16 | 2023-09-27 | 재단법인 전남바이오산업진흥원 | 뇌경색 예방 또는 치료용 조성물 |
Family Cites Families (497)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
| US2007A (en) * | 1841-03-16 | Improvement in the mode of harvesting grain | ||
| US1529202A (en) | 1924-07-16 | 1925-03-10 | Joseph H Miller | Festooning machine for carrying paper and the like |
| GB1529202A (en) | 1976-02-20 | 1978-10-18 | Ciba Geigy Ag | Spectral sensitising dyes |
| US5583013A (en) | 1977-11-08 | 1996-12-10 | Genentech, Inc. | Method and means for microbial polypeptide expression |
| US5221619A (en) | 1977-11-08 | 1993-06-22 | Genentech, Inc. | Method and means for microbial polypeptide expression |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| JPS55116259A (en) | 1979-03-01 | 1980-09-06 | Fuji Photo Film Co Ltd | Microimmunoassay method |
| JPS5745460A (en) | 1980-09-02 | 1982-03-15 | Fuji Photo Film Co Ltd | Inspection sheet for measuring trace component and inspecting method using said sheet |
| DE3170135D1 (en) | 1980-09-02 | 1985-05-30 | Fuji Photo Film Co Ltd | Method for immunochemical measurement of trace components |
| NL8200523A (nl) | 1982-02-11 | 1983-09-01 | Univ Leiden | Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna. |
| US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
| US4828979A (en) | 1984-11-08 | 1989-05-09 | Life Technologies, Inc. | Nucleotide analogs for nucleic acid labeling and detection |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US4682195A (en) | 1985-09-30 | 1987-07-21 | General Electric Company | Insulated gate device with configured emitter contact pad |
| US4959463A (en) | 1985-10-15 | 1990-09-25 | Genentech, Inc. | Intermediates |
| US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
| US5011769A (en) * | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US4876187A (en) | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US4910300A (en) | 1985-12-11 | 1990-03-20 | Chiron Corporation | Method for making nucleic acid probes |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| EP0266032A1 (en) | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US4816571A (en) | 1987-06-04 | 1989-03-28 | Applied Biosystems, Inc. | Chemical capping by phosphitylation during oligonucleotide synthesis |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4952500A (en) | 1988-02-01 | 1990-08-28 | University Of Georgia Research Foundation, Inc. | Cloning systems for Rhodococcus and related bacteria |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US4999290A (en) * | 1988-03-31 | 1991-03-12 | The Board Of Regents, The University Of Texas System | Detection of genomic abnormalities with unique aberrant gene transcripts |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5602244A (en) | 1988-05-26 | 1997-02-11 | Competitive Technologies, Inc. | Polynucleotide phosphorodithioate compounds |
| GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| US5708154A (en) | 1989-02-24 | 1998-01-13 | City Of Hope | RNA-DNA hybrid molecules of nucleic acid |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5141813A (en) | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
| GB8920097D0 (en) | 1989-09-06 | 1989-10-18 | Ici Plc | Amplification processes |
| US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| JPH05504552A (ja) | 1989-10-24 | 1993-07-15 | ギリアド サイエンシズ,インコーポレイテッド | 2’位が改変されたオリゴヌクレオチド |
| US5188934A (en) * | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
| US5486603A (en) * | 1990-01-08 | 1996-01-23 | Gilead Sciences, Inc. | Oligonucleotide having enhanced binding affinity |
| US6153737A (en) | 1990-01-11 | 2000-11-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| US5872232A (en) | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
| US5859221A (en) | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5670633A (en) | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| GB9009980D0 (en) | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5614617A (en) | 1990-07-27 | 1997-03-25 | Isis Pharmaceuticals, Inc. | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
| US5223618A (en) | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
| US5965364A (en) | 1990-10-09 | 1999-10-12 | Benner; Steven Albert | Method for selecting functional deoxyribonucleotide derivatives |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| WO1992007095A1 (en) * | 1990-10-15 | 1992-04-30 | Stratagene | Arbitrarily primed polymerase chain reaction method for fingerprinting genomes |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| US6287792B1 (en) | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
| AU662906B2 (en) * | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| US6369209B1 (en) * | 1999-05-03 | 2002-04-09 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5256555A (en) * | 1991-12-20 | 1993-10-26 | Ambion, Inc. | Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions |
| US5700922A (en) | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| US5260191A (en) | 1992-01-30 | 1993-11-09 | Agracetus, Inc. | Method for diagnosing tumors |
| EP0628051B1 (en) | 1992-02-12 | 2003-07-02 | Chromagen, Inc. | Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides |
| US5652099A (en) | 1992-02-12 | 1997-07-29 | Conrad; Michael J. | Probes comprising fluorescent nucleosides and uses thereof |
| DE4204650C1 (cg-RX-API-DMAC7.html) | 1992-02-15 | 1993-07-08 | Hoffmeister, Helmut, Dr., 4400 Muenster, De | |
| ATE278807T1 (de) | 1992-02-19 | 2004-10-15 | New York Health Res Inst | Neue anordnungen von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzierung und manipulieren von nukleinsäuren |
| WO1993018176A1 (en) | 1992-03-11 | 1993-09-16 | Dana-Farber Cancer Institute | METHODS TO CLONE mRNA |
| US5262311A (en) | 1992-03-11 | 1993-11-16 | Dana-Farber Cancer Institute, Inc. | Methods to clone polyA mRNA |
| JP2775346B2 (ja) | 1992-04-03 | 1998-07-16 | アプライド バイオシステムズ,インコーポレイテッド | プローブ構成物および方法 |
| GB9208545D0 (en) | 1992-04-21 | 1992-06-03 | Gatsby Charitable Foundation T | Virus resistant plants |
| US5428148A (en) | 1992-04-24 | 1995-06-27 | Beckman Instruments, Inc. | N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis |
| EP1983056A1 (en) | 1992-07-07 | 2008-10-22 | Japan Tobacco Inc. | Method for transforming monocotyledons |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| HUT70467A (en) | 1992-07-27 | 1995-10-30 | Pioneer Hi Bred Int | An improved method of agrobactenium-mediated transformation of cultvred soyhean cells |
| US5438131A (en) | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5858988A (en) | 1993-02-24 | 1999-01-12 | Wang; Jui H. | Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| US5580726A (en) | 1994-04-29 | 1996-12-03 | Geron Corporation | Method and Kit for enhanced differential display |
| US5767259A (en) * | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
| US5472672A (en) | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
| JPH09507121A (ja) | 1993-10-26 | 1997-07-22 | アフィマックス テクノロジーズ ナームロゼ ベノートスハップ | 生物学的チップ上の核酸プローブアレー |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| US5610287A (en) | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| JPH09508800A (ja) | 1994-02-14 | 1997-09-09 | スミスクライン・ビーチャム・コーポレイション | 差次的発現遺伝子の同定法 |
| DE4406524A1 (de) | 1994-02-28 | 1995-08-31 | Boehringer Mannheim Gmbh | 3'-RNA-Markierung mit Terminaler Transferase |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| AU696455C (en) | 1994-03-23 | 2006-03-02 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US5972901A (en) | 1994-03-23 | 1999-10-26 | Case Western Reserve University | Serpin enzyme complex receptor--mediated gene transfer |
| US5844107A (en) | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| US6146886A (en) | 1994-08-19 | 2000-11-14 | Ribozyme Pharmaceuticals, Inc. | RNA polymerase III-based expression of therapeutic RNAs |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5574146A (en) | 1994-08-30 | 1996-11-12 | Beckman Instruments, Inc. | Oligonucleotide synthesis with substituted aryl carboxylic acids as activators |
| US5554744A (en) | 1994-09-23 | 1996-09-10 | Hybridon, Inc. | Method for loading solid supports for nucleic acid synthesis |
| US6096314A (en) | 1994-10-07 | 2000-08-01 | Yeda Research And Development Co. Ltd. | Peptides and pharmaceutical compositions comprising them |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| EP1505159B1 (en) * | 1995-03-17 | 2008-05-28 | John Wayne Cancer Institute | Detection of breast metastases with a multiple marker assay |
| US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| DE19518505A1 (de) | 1995-05-19 | 1996-11-21 | Max Planck Gesellschaft | Verfahren zur Genexpressionsanalyse |
| US6111095A (en) | 1995-06-07 | 2000-08-29 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| AU723163B2 (en) | 1995-06-07 | 2000-08-17 | Tekmira Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US6998268B2 (en) | 1995-07-03 | 2006-02-14 | Dainippon Sumitomo Pharma Co. Ltd. | Gene preparations |
| US5637683A (en) | 1995-07-13 | 1997-06-10 | Cornell Research Foundation, Inc. | Nucleic acid analog with amide linkage and method of making that analog |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| US5658734A (en) | 1995-10-17 | 1997-08-19 | International Business Machines Corporation | Process for synthesizing chemical compounds |
| US5705629A (en) | 1995-10-20 | 1998-01-06 | Hybridon, Inc. | Methods for H-phosphonate synthesis of mono- and oligonucleotides |
| US6418382B2 (en) * | 1995-10-24 | 2002-07-09 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5871697A (en) * | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US20040142895A1 (en) | 1995-10-26 | 2004-07-22 | Sirna Therapeutics, Inc. | Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US5998203A (en) * | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| EP0880598A4 (en) * | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US5670663A (en) | 1996-02-14 | 1997-09-23 | Regents Of The University Of California | Recovery of taxanes from conifers |
| US6020481A (en) * | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| WO1997039008A1 (en) | 1996-04-12 | 1997-10-23 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
| US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US5863727A (en) * | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US6184037B1 (en) | 1996-05-17 | 2001-02-06 | Genemedicine, Inc. | Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US5739169A (en) * | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| ATE318327T1 (de) * | 1996-06-04 | 2006-03-15 | Univ Utah Res Found | Fluoreszenz-donor-akzeptor paar |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US6770291B2 (en) | 1996-08-30 | 2004-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
| GB9618050D0 (en) | 1996-08-29 | 1996-10-09 | Cancer Res Campaign Tech | Global amplification of nucleic acids |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| US5886165A (en) | 1996-09-24 | 1999-03-23 | Hybridon, Inc. | Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments |
| ES2331388T3 (es) | 1997-03-07 | 2009-12-30 | Siemens Healthcare Diagnostics Inc. | Marcador especifico para el cancer de prostata. |
| EP0921195A1 (en) | 1997-03-10 | 1999-06-09 | Japan Tobacco Inc. | Antisense base sequences |
| US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
| US6090556A (en) | 1997-04-07 | 2000-07-18 | Japan Science & Technology Corporation | Method for quantitatively determining the expression of a gene |
| NO972006D0 (no) | 1997-04-30 | 1997-04-30 | Forskningsparken I Aas As | Ny metode for diagnose av sykdommer |
| DE69841002D1 (de) | 1997-05-14 | 2009-09-03 | Univ British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
| US6262252B1 (en) | 1997-05-19 | 2001-07-17 | Mirus, Inc. | Single-step method for labeling nucleic acids with mustard or aziridine labeling reagents |
| US5919626A (en) | 1997-06-06 | 1999-07-06 | Orchid Bio Computer, Inc. | Attachment of unmodified nucleic acids to silanized solid phase surfaces |
| WO1998056954A1 (en) | 1997-06-13 | 1998-12-17 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
| US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| AU1366299A (en) * | 1997-10-27 | 1999-05-17 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| EP1032705B1 (en) | 1997-10-30 | 2011-12-14 | Cold Spring Harbor Laboratory | Probe arrays and methods of using probe arrays for distinguishing dna |
| US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6232066B1 (en) * | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
| US6238869B1 (en) * | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
| US6458533B1 (en) | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US6121058A (en) | 1998-01-02 | 2000-09-19 | Intel Corporation | Method for removing accumulated solder from probe card probing features |
| US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
| US5942398A (en) | 1998-02-26 | 1999-08-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glutx and uses thereof |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| WO1999054459A2 (en) | 1998-04-20 | 1999-10-28 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
| US6037129A (en) * | 1998-05-28 | 2000-03-14 | Medical University Of South Carolina | Multi-marker RT-PCR panel for detecting metastatic breast cancer |
| FR2780059B1 (fr) | 1998-06-17 | 2002-10-11 | Bio Merieux | Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus |
| US6576420B1 (en) | 1998-06-23 | 2003-06-10 | Regents Of The University Of California | Method for early diagnosis of, and determination of prognosis in, cancer |
| GB9815799D0 (en) | 1998-07-21 | 1998-09-16 | Pharmagene Lab Limited | Quantitative analysis of gene expression |
| US6730477B1 (en) * | 1998-08-04 | 2004-05-04 | Diadexus, Inc. | Method of diagnosing, monitoring and staging breast cancer |
| US6140054A (en) | 1998-09-30 | 2000-10-31 | University Of Utah Research Foundation | Multiplex genotyping using fluorescent hybridization probes |
| WO2000024939A1 (en) | 1998-10-27 | 2000-05-04 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| GB9904991D0 (en) * | 1999-03-05 | 1999-04-28 | Univ Nottingham | Genetic screening |
| EP1161439B1 (en) | 1999-03-18 | 2010-04-21 | Exiqon A/S | Xylo-lna analogues |
| US6383752B1 (en) * | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| US6103576A (en) * | 1999-04-13 | 2000-08-15 | Microchip Technology Incorporated | Dielectric layer of a memory cell having a stacked oxide sidewall and method of fabricating same |
| CN102180924A (zh) | 1999-05-04 | 2011-09-14 | 桑塔里斯制药公司 | L-核糖-lna类似物 |
| US6638717B2 (en) | 1999-05-19 | 2003-10-28 | Aventis Pharmaceuticals, Inc. | Microarray-based subtractive hybridzation |
| WO2000071096A2 (en) | 1999-05-24 | 2000-11-30 | Introgen Therapeutics, Inc. | Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases |
| US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
| CA2377385A1 (en) | 1999-06-03 | 2000-12-14 | Jessie L.S. Au | Methods and compositions for modulating cell proliferation and cell death |
| AU4332399A (en) | 1999-06-04 | 2000-12-28 | Cheng-Ming Chuong | Rna polymerase chain reaction |
| US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
| US6201112B1 (en) | 1999-07-22 | 2001-03-13 | Agilent Technologies Inc. | Method for 3′ end-labeling ribonucleic acids |
| US7005261B1 (en) * | 1999-07-29 | 2006-02-28 | British Biocell International Limited | Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter |
| US6140500A (en) | 1999-09-03 | 2000-10-31 | Pe Corporation | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
| US6511832B1 (en) * | 1999-10-06 | 2003-01-28 | Texas A&M University System | In vitro synthesis of capped and polyadenylated mRNAs using baculovirus RNA polymerase |
| US20020094546A1 (en) | 1999-10-07 | 2002-07-18 | Shimkets Richard A. | Growth factor polypeptides and nucleic acids encoding same |
| JP2003516124A (ja) | 1999-10-15 | 2003-05-13 | ユニバーシティー オブ マサチューセッツ | 標的とした遺伝的干渉の手段としてのrna干渉経路遺伝子 |
| US6528254B1 (en) * | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| US6191278B1 (en) * | 1999-11-03 | 2001-02-20 | Pe Corporation | Water-soluble rhodamine dyes and conjugates thereof |
| US6458382B1 (en) | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
| US6435245B1 (en) | 1999-11-18 | 2002-08-20 | Pitney Bowes Inc. | System for folding and tabbing sheets |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| WO2001038580A2 (en) | 1999-11-26 | 2001-05-31 | Curagen Corporation | Nucleic acid probe arrays |
| US6383749B2 (en) | 1999-12-02 | 2002-05-07 | Clontech Laboratories, Inc. | Methods of labeling nucleic acids for use in array based hybridization assays |
| US7205105B2 (en) * | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
| US6618679B2 (en) | 2000-01-28 | 2003-09-09 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| US8202979B2 (en) * | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US20070026394A1 (en) | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| US6447723B1 (en) | 2000-03-13 | 2002-09-10 | Packard Instrument Company, Inc. | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments |
| US20030084471A1 (en) * | 2000-03-16 | 2003-05-01 | David Beach | Methods and compositions for RNA interference |
| WO2001070095A2 (en) | 2000-03-23 | 2001-09-27 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| EP1268818A2 (en) | 2000-03-24 | 2003-01-02 | Millennium Pharmaceuticals, Inc. | 18221, dual specificity phosphatase and uses thereof |
| US6787335B2 (en) | 2000-03-27 | 2004-09-07 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating mammary gland cancer |
| WO2001073030A2 (en) | 2000-03-28 | 2001-10-04 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer |
| AU2001251084A1 (en) | 2000-03-29 | 2001-10-08 | Diadexus, Inc. | Polynucleotides and polypeptides as well as methods for diagnosing and treating lung cancer |
| AU2001251223A1 (en) | 2000-03-30 | 2001-10-15 | Diadexus, Inc. | Compositions and methods for diagnosing, monitoring, staging, imaging and treating stomach cancer |
| AU2001249622B2 (en) * | 2000-03-30 | 2007-06-07 | Massachusetts Institute Of Technology | RNA sequence-specific mediators of RNA interference |
| US6573048B1 (en) * | 2000-04-18 | 2003-06-03 | Naxcor | Degradable nucleic acid probes and nucleic acid detection methods |
| EP1366366B1 (en) | 2000-05-10 | 2010-10-20 | Signe BioPharma Inc. | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers |
| US20020042388A1 (en) | 2001-05-01 | 2002-04-11 | Cooper Mark J. | Lyophilizable and enhanced compacted nucleic acids |
| CA2410887C (en) | 2000-06-02 | 2012-07-24 | Bracco Research Usa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| CA2414396A1 (en) | 2000-06-26 | 2002-01-03 | The United States Of America, As Represented By The Secretary Of Agricul Ture | Production of vaccines using transgenic plants |
| EP1297185A2 (en) | 2000-06-30 | 2003-04-02 | Epigenomics AG | Diagnosis of diseases associated with signal transduction |
| US6596490B2 (en) * | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| DK1325008T3 (da) | 2000-07-31 | 2006-02-13 | Hoffmann La Roche | Piperazinderivater |
| AU2001281136A1 (en) | 2000-08-04 | 2002-02-18 | Board Of Regents, The University Of Texas System | Detection and diagnosis of smoking related cancers |
| JP2002067789A (ja) * | 2000-09-05 | 2002-03-08 | Yazaki Corp | ランプユニットの電線接続構造 |
| US20030031678A1 (en) | 2000-09-19 | 2003-02-13 | Shujath Ali | Compositions and methods relating to prostate specific genes and proteins |
| US20030082604A1 (en) | 2000-09-27 | 2003-05-01 | Swanson Melvin J. | High density arrays |
| US7162371B1 (en) | 2000-10-11 | 2007-01-09 | Georgia Tech Research Corporation | Differentially-expressed conifer cDNAs, and their use in improving somatic embryogenesis |
| US6617112B2 (en) | 2000-10-11 | 2003-09-09 | Monsanto Technology Llc | Methods for gene array analysis of nuclear runoff transcripts |
| US6350580B1 (en) * | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| US20020150626A1 (en) | 2000-10-16 | 2002-10-17 | Kohane Daniel S. | Lipid-protein-sugar particles for delivery of nucleic acids |
| WO2002048168A1 (en) * | 2000-10-24 | 2002-06-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of tnfr1 expression |
| US7001724B1 (en) * | 2000-11-28 | 2006-02-21 | Applera Corporation | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases |
| EP1873259B1 (en) | 2000-12-01 | 2012-01-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | RNA interference mediated by 21 and 22nt RNAs |
| GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
| WO2002046470A2 (en) | 2000-12-04 | 2002-06-13 | Primagen Holding B.V. | Testing endosymbiont cellular organelles and compounds identifiable therewith |
| US20030099976A1 (en) | 2001-01-17 | 2003-05-29 | Tai-Jay Chang | Androgen receptor complex-associated protein |
| US20040115671A1 (en) | 2001-01-18 | 2004-06-17 | Zlokovic Berislav V | Gene expression profiling of endothelium in alzheimer's disease |
| US7015047B2 (en) * | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
| US20040110191A1 (en) * | 2001-01-31 | 2004-06-10 | Winkler Matthew M. | Comparative analysis of nucleic acids using population tagging |
| US20040058373A1 (en) * | 2001-01-31 | 2004-03-25 | Winkler Matthew M. | Competitive amplification of fractionated targets from multiple nucleic acid samples |
| WO2002064835A2 (en) | 2001-01-31 | 2002-08-22 | Ambion, Inc. | Methods for nucleic acid fingerprint analysis |
| WO2002073504A1 (en) | 2001-03-14 | 2002-09-19 | Gene Logic, Inc. | A system and method for retrieving and using gene expression data from multiple sources |
| US20030170623A1 (en) | 2001-04-13 | 2003-09-11 | Jingwen Chen | Multiplexed gene analysis on a mobile solid support |
| AU2002307438A1 (en) | 2001-04-20 | 2002-11-05 | Ludwig Institute For Cancer Research | Cancer-testis antigens |
| US20050065333A1 (en) | 2001-04-27 | 2005-03-24 | Arun Seth | Breast cancer-associated genes and uses thereof |
| US20030203865A1 (en) | 2001-04-30 | 2003-10-30 | Pierrot Harvie | Lipid-comprising drug delivery complexes and methods for their production |
| AUPR480901A0 (en) | 2001-05-04 | 2001-05-31 | Genomics Research Partners Pty Ltd | Diagnostic method for assessing a condition of a performance animal |
| WO2003070917A2 (en) * | 2002-02-20 | 2003-08-28 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of myc and myb genes or genes of their respective pathways |
| US20040209832A1 (en) | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| CA2448915A1 (en) | 2001-06-01 | 2002-12-12 | Prosanos Corporation | Information processing method for disease stratification and assessment of disease progressing |
| US7171311B2 (en) * | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
| US20040086504A1 (en) | 2001-06-21 | 2004-05-06 | Deepak Sampath | Cyr61 as a target for treatment and diagnosis of breast cancer |
| AU2002315413A1 (en) | 2001-06-22 | 2003-01-08 | Gene Logic, Inc. | Platform for management and mining of genomic data |
| US7297480B2 (en) | 2001-06-28 | 2007-11-20 | Dermtech International | Method for detection of melanoma |
| JP4572276B2 (ja) | 2001-06-29 | 2010-11-04 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | T細胞調節遺伝子およびその使用方法 |
| US20030143571A1 (en) | 2001-08-08 | 2003-07-31 | North Carolina State University | Infectious disease microarray |
| AU2002331777A1 (en) | 2001-08-30 | 2003-03-18 | Spectral Genomics, Inc. | Arrays comprising pre-labeled biological molecules and methods for making and using these arrays |
| US20030198627A1 (en) * | 2001-09-01 | 2003-10-23 | Gert-Jan Arts | siRNA knockout assay method and constructs |
| WO2003021227A2 (en) | 2001-09-05 | 2003-03-13 | The Children's Hospital Of Philadelphia | Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors |
| JP2005502365A (ja) | 2001-09-06 | 2005-01-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | アレイ状に配置した増大させた生体試料の核酸の表示配列中における生体試料の遺伝分析 |
| JP2005528582A (ja) | 2001-09-07 | 2005-09-22 | コーニング インコーポレイテッド | ハイスループット分析のためのマイクロカラム・プラットフォームに基づくアレイ |
| ES2336433T3 (es) * | 2001-09-19 | 2010-04-13 | Alexion Pharmaceuticals, Inc. | Moldes modififcados mediante ingenieria genetica y su uso en amplificacion de cebador unico. |
| CA2452288A1 (en) * | 2001-09-20 | 2003-03-27 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for psma |
| US6593091B2 (en) * | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
| EP2428568B1 (en) * | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| EP1434883A2 (en) | 2001-10-02 | 2004-07-07 | Azign Bioscience A/S | Specific differential display arrays |
| US7335470B2 (en) | 2001-10-12 | 2008-02-26 | Perkinelmer, Las, Inc. | Compilations of nucleic acids and arrays and methods of using them |
| US20040063654A1 (en) * | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
| US20030157030A1 (en) | 2001-11-02 | 2003-08-21 | Insert Therapeutics, Inc. | Methods and compositions for therapeutic use of rna interference |
| US20030087298A1 (en) | 2001-11-02 | 2003-05-08 | Roland Green | Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe |
| WO2003043487A2 (en) | 2001-11-19 | 2003-05-30 | Protometrix, Inc. | Method of using a non-antibody protein to detect and measure an analyte |
| CN1927466A (zh) | 2001-12-19 | 2007-03-14 | 阿菲梅特里克斯公司 | 阵列板和阵列板的构建方法 |
| AU2002360773A1 (en) * | 2001-12-27 | 2003-07-24 | Agy Therapeutics, Inc. | Use of biomolecular targets in the treatment and visualization of tumors |
| US7141372B2 (en) | 2002-01-18 | 2006-11-28 | Health Research Incorporated | Universal RT-coupled PCR method for the specific amplification of mRNA |
| US20030215842A1 (en) | 2002-01-30 | 2003-11-20 | Epigenomics Ag | Method for the analysis of cytosine methylation patterns |
| CA2474530A1 (en) | 2002-02-07 | 2003-08-14 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Diagnostic microarray and method of use thereof |
| AU2003212954A1 (en) | 2002-02-08 | 2003-09-02 | Integriderm, Inc. | Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays |
| CA2478605A1 (en) | 2002-03-07 | 2003-09-18 | University Of Utah Research Foundation | Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data analysis |
| JP2005521420A (ja) | 2002-04-03 | 2005-07-21 | エージーワイ セラピューティクス インコーポレイティッド | 脳腫瘍の処置及び可視化における生体分子標的の使用法 |
| US20070025997A1 (en) | 2002-04-03 | 2007-02-01 | Usha Nagavarapu | Use of biomolecular targets in the treatment and visualization of brain tumors |
| CA2524569C (en) | 2002-05-03 | 2013-10-22 | Duke University | A method of regulating gene expression |
| US7006680B2 (en) | 2002-05-03 | 2006-02-28 | Vialogy Corp. | System and method for characterizing microarray output data |
| IL164321A0 (en) | 2002-05-20 | 2005-12-18 | Northrop Grumman Corp | Automatic point source biological agetectio system |
| EP1546378B1 (en) | 2002-05-24 | 2011-06-22 | Roche NimbleGen, Inc. | Microarrays and method for running hybridization reaction for multiple samples on a single microarray |
| AUPS261402A0 (en) | 2002-05-28 | 2002-06-20 | Compusign Pty Ltd | Array monitoring |
| US20030228579A1 (en) | 2002-06-05 | 2003-12-11 | Uri Alon | Ordering genes by analysis of expression kinetics |
| EP3222724B1 (en) | 2002-08-05 | 2018-10-31 | Silence Therapeutics GmbH | Further novel forms of interfering rna molecules |
| WO2004014933A1 (en) * | 2002-08-07 | 2004-02-19 | University Of Massachusetts | Compositions for rna interference and methods of use thereof |
| US20040029128A1 (en) | 2002-08-08 | 2004-02-12 | Epigenomics, Inc. | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
| US20040029121A1 (en) | 2002-08-08 | 2004-02-12 | Susan Cottrell | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
| EP1560924A4 (en) | 2002-08-16 | 2006-05-31 | Wayne John Cancer Inst | MOLECULAR LYMPHATIC MAPPING OF VIRCHOV LYMPHOTIC NODES |
| US20040114800A1 (en) | 2002-09-12 | 2004-06-17 | Baylor College Of Medicine | System and method for image segmentation |
| WO2004027093A1 (en) | 2002-09-19 | 2004-04-01 | The Chancellor, Master And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
| ATE513843T1 (de) | 2002-09-25 | 2011-07-15 | Univ Massachusetts | Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna |
| JP4443418B2 (ja) | 2002-11-01 | 2010-03-31 | ザ リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | 神経系疾患及び癌における非定型プロテインキナーゼcアイソフォーム |
| EP1418241A1 (en) | 2002-11-08 | 2004-05-12 | PrimaGen Holding B.V. | Method for quantifying a ratio between at least two nucleic acid sequences |
| AU2003291433B2 (en) | 2002-11-13 | 2008-05-22 | Thomas Jefferson University | Compositions and methods for cancer diagnosis and therapy |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| US7655785B1 (en) | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| US20040175732A1 (en) | 2002-11-15 | 2004-09-09 | Rana Tariq M. | Identification of micrornas and their targets |
| US20040214198A1 (en) | 2002-11-15 | 2004-10-28 | University Of Massachusetts | Allele-targeted RNA interference |
| WO2004050125A1 (ja) | 2002-12-03 | 2004-06-17 | Koken Co.,Ltd. | 腫瘍細胞の増殖及び/又は浸潤の抑制剤 |
| US7851150B2 (en) * | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
| CA2510381C (en) * | 2002-12-18 | 2014-07-08 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
| AU2004204820A1 (en) | 2003-01-13 | 2004-07-29 | Emory University | Methods of detecting gene expression in normal and cancerous cells |
| CA2513744C (en) | 2003-01-16 | 2013-12-24 | North Carolina State University | Depletion of endogenous primordial germ cells in avian species |
| WO2004066183A2 (en) * | 2003-01-22 | 2004-08-05 | European Molecular Biology Laboratory | Microrna |
| US20040147027A1 (en) * | 2003-01-28 | 2004-07-29 | Troy Carol M. | Complex for facilitating delivery of dsRNA into a cell and uses thereof |
| KR20050115231A (ko) | 2003-02-10 | 2005-12-07 | 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 | 포유동물 세포의 조절 |
| US7816337B2 (en) | 2003-02-18 | 2010-10-19 | Roche Madison Inc. | Reversible attachment of a membrane active polymer to a polynucleotide |
| US20040224337A1 (en) | 2003-03-04 | 2004-11-11 | Erik Foehr | Use of biomolecular targets in the treatment and visualization of tumors |
| EP1604022A2 (en) * | 2003-03-06 | 2005-12-14 | Oligo Engine, Inc. | Modulation of gene expression using dna-rna hybrids |
| WO2004090108A2 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | Irna conjugates |
| US20050112604A1 (en) | 2003-03-14 | 2005-05-26 | Akihide Fujimoto | Loss of heterozygosity of the DNA markers in the 12q22-23 region |
| US7718364B2 (en) | 2003-03-25 | 2010-05-18 | John Wayne Cancer Institute | DNA markers for management of cancer |
| US20040198640A1 (en) | 2003-04-02 | 2004-10-07 | Dharmacon, Inc. | Stabilized polynucleotides for use in RNA interference |
| JP4605799B2 (ja) * | 2003-04-02 | 2011-01-05 | ダーマコン, インコーポレイテッド | Rna干渉において使用するための修飾ポリヌクレオチド |
| US20040229211A1 (en) | 2003-05-13 | 2004-11-18 | Yeung Wah Hin Alex | Sensitive diagnostic testing methodology using multiplex real time PCR with one dye (MOD) and its use as in severe acute respiratory syndrome (SARS) |
| WO2004105573A2 (en) | 2003-05-21 | 2004-12-09 | The Wistar Institute Of Anatomy And Biology | Method of diagnosis of cancer based on gene expression profiles in cells |
| DK1633767T3 (en) | 2003-06-02 | 2019-03-25 | Univ Massachusetts | METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING |
| US7750144B2 (en) | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| EP1633890B2 (en) | 2003-06-02 | 2020-11-18 | University of Massachusetts | METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi |
| US20050059024A1 (en) | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
| CA2533701A1 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050037362A1 (en) | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| US20060183128A1 (en) | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| WO2005017145A1 (ja) | 2003-08-13 | 2005-02-24 | Japan Biological Informatics Consortium | 機能性rnaが制御する被制御遺伝子の同定・予測方法及びその利用方法 |
| KR20060125743A (ko) | 2003-11-10 | 2006-12-06 | 녹손 파르마 아게 | 생체 활성형 그렐린에 특이적으로 결합하는 핵산 |
| US20050130170A1 (en) | 2003-12-16 | 2005-06-16 | Jeanne Harvey | Identification and verification of methylation marker sequences |
| US20050130172A1 (en) | 2003-12-16 | 2005-06-16 | Bayer Corporation | Identification and verification of methylation marker sequences |
| WO2005078139A2 (en) | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
| WO2005079397A2 (en) * | 2004-02-13 | 2005-09-01 | Rockefeller University | Anti-microrna oligonucleotide molecules |
| US20050182005A1 (en) | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
| KR100522307B1 (ko) * | 2004-02-19 | 2005-10-19 | 변영철 | 화장용브러시 |
| US7402389B2 (en) | 2004-02-24 | 2008-07-22 | The Translational Genomics Research Institute (Tgen) | Compositions and methods for prognosis of cancers |
| US20060195266A1 (en) | 2005-02-25 | 2006-08-31 | Yeatman Timothy J | Methods for predicting cancer outcome and gene signatures for use therein |
| WO2005102456A1 (en) * | 2004-03-27 | 2005-11-03 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Composition and method for cancer treatment |
| US20060134639A1 (en) | 2004-04-06 | 2006-06-22 | Huffel Christophe V | Method for the determination of cellular transcriptional regulation |
| US7365058B2 (en) * | 2004-04-13 | 2008-04-29 | The Rockefeller University | MicroRNA and methods for inhibiting same |
| KR20070004957A (ko) * | 2004-04-20 | 2007-01-09 | 제나코 바이오메디컬 프로덕츠, 인코포레이티드 | ncRNA 검출 방법 |
| EP2500431A3 (en) | 2004-05-04 | 2013-12-18 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for reducing viral genome amounts in a target cell |
| WO2005111211A2 (en) * | 2004-05-14 | 2005-11-24 | Rosetta Genomics Ltd. | Micronas and uses thereof |
| WO2005116261A2 (en) | 2004-05-24 | 2005-12-08 | Albert Einstein College Of Medecine Of Yeshiva University | Rna expression microarrays |
| US7575863B2 (en) | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US20050287539A1 (en) | 2004-06-29 | 2005-12-29 | Emmanuel Labourier | Methods and compositions for preparing capped RNA |
| AU2005328382C1 (en) | 2004-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
| US7582744B2 (en) | 2004-08-10 | 2009-09-01 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides |
| US7893034B2 (en) | 2004-09-02 | 2011-02-22 | Yale University | Regulation of oncogenes by microRNAs |
| US20060057595A1 (en) | 2004-09-16 | 2006-03-16 | Applera Corporation | Compositions, methods, and kits for identifying and quantitating small RNA molecules |
| US20090186353A1 (en) | 2004-10-04 | 2009-07-23 | Rosetta Genomics Ltd. | Cancer-related nucleic acids |
| US7825229B2 (en) | 2005-03-25 | 2010-11-02 | Rosetta Genomics Ltd. | Lung cancer-related nucleic acids |
| US7592441B2 (en) | 2004-10-04 | 2009-09-22 | Rosetta Genomics Ltd | Liver cancer-related nucleic acids |
| US7642348B2 (en) | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| WO2006042328A2 (en) | 2004-10-12 | 2006-04-20 | John Wayne Cancer Institute | Treatment of cancer and compositions |
| US20060078894A1 (en) * | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
| FR2877350B1 (fr) * | 2004-11-03 | 2010-08-27 | Centre Nat Rech Scient | IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE |
| WO2008073922A2 (en) | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| AU2005333165B2 (en) | 2004-11-12 | 2012-07-19 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| US7074622B2 (en) * | 2004-11-15 | 2006-07-11 | Eastman Kodak Company | Method and system for sorting and separating particles |
| JP2008521412A (ja) | 2004-11-30 | 2008-06-26 | ベリデックス・エルエルシー | 肺癌予後判定手段 |
| US20060154275A1 (en) | 2004-12-02 | 2006-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Regulated genes in cervical cancer |
| US20060185027A1 (en) | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| WO2006069584A2 (en) * | 2004-12-29 | 2006-07-06 | Exiqon A/S | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs |
| JP2008531481A (ja) * | 2005-02-08 | 2008-08-14 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 癌の治療のための、mda−7を含む組成物および方法 |
| US20090062184A1 (en) | 2005-03-24 | 2009-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Fine particulate preparation comprising complex of nucleic acid molecule and collagen |
| US7495073B2 (en) * | 2005-03-24 | 2009-02-24 | Asia Hepato Gene Company | Short isoform of Annexin A10 at chromosome 4q, termed Annexin 10s (ANXA10s) and methods of use |
| US8895717B2 (en) | 2005-04-15 | 2014-11-25 | The Board Of Regents Of The University Of Texas System | Delivery of siRNA by neutral lipid compositions |
| GB2425311A (en) * | 2005-04-15 | 2006-10-25 | Ist Superiore Sanita | Micro RNA against kit protein |
| WO2006119365A2 (en) | 2005-05-02 | 2006-11-09 | Cold Spring Harbor Laboratory | Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster |
| US20070072201A1 (en) * | 2005-05-16 | 2007-03-29 | Kohne David E | Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results |
| US20060265771A1 (en) * | 2005-05-17 | 2006-11-23 | Lewis David L | Monitoring microrna expression and function |
| GB0601102D0 (en) * | 2006-01-19 | 2006-03-01 | Nuclea Biomarkers Llc | Kinase Peptides And Antibodies |
| US20070054287A1 (en) * | 2005-05-31 | 2007-03-08 | Applera Corporation | Method for identifying medically important cell populations using micro rna as tissue specific biomarkers |
| CA2610702A1 (en) | 2005-06-03 | 2006-12-07 | Michael Zenon Michael | Targeting cells with altered microrna expression |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| EP1896602A4 (en) | 2005-06-09 | 2009-08-12 | Epoch Biosciences Inc | IMPROVED AMPLIFICATION PROCESSES ON PRIMER BASIS |
| US20060292616A1 (en) | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
| KR101140575B1 (ko) * | 2005-06-30 | 2012-05-02 | 엘지디스플레이 주식회사 | 액정표시장치 검사공정 |
| CN102533966B (zh) | 2005-08-01 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| IL177006A0 (en) | 2005-08-02 | 2006-12-10 | Veridex Llc | Predicting bone relapse of breast cancer |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| US20070041934A1 (en) | 2005-08-12 | 2007-02-22 | Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
| CA2845251A1 (en) | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof |
| AU2006311808A1 (en) | 2005-11-04 | 2007-05-18 | Merck Sharp & Dohme Corp. | Methods of using SAHA and bortezomib for treating cancer |
| US7390792B2 (en) | 2005-12-15 | 2008-06-24 | Board Of Regents, The University Of Texas System | MicroRNA1 therapies |
| CN103301475B (zh) | 2005-12-28 | 2016-08-03 | 斯克里普斯研究所 | 药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用 |
| EP1966390A1 (en) | 2005-12-29 | 2008-09-10 | Exiqon A/S | Detection of tissue origin of cancer |
| EP2479286B1 (en) | 2006-01-05 | 2013-11-13 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
| EP2514434B1 (en) | 2006-01-05 | 2015-10-21 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer |
| WO2007087451A2 (en) | 2006-01-25 | 2007-08-02 | University Of Massachusetts | Compositions and methods for enhancing discriminatory rna interference |
| EP1984499B1 (en) | 2006-01-27 | 2015-05-27 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| AU2007223311C1 (en) | 2006-03-02 | 2013-06-20 | The Board Of Regents Of The University Of Oklahoma | MicroRNA expression profile associated with pancreatic cancer |
| US7955848B2 (en) | 2006-04-03 | 2011-06-07 | Trustees Of Dartmouth College | MicroRNA biomarkers for human breast and lung cancer |
| US8106024B2 (en) * | 2006-06-16 | 2012-01-31 | Taisho Pharmaceutical Co., Ltd. | Method of treating cancer with an RPN2 gene expression inhibitor |
| US20080076674A1 (en) * | 2006-07-06 | 2008-03-27 | Thomas Litman | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer |
| ES2562607T3 (es) | 2006-07-13 | 2016-03-07 | The Ohio State University Research Foundation | MIR-21 para el diagnóstico de adenocarcinoma de colon con mal pronóstico de supervivencia |
| WO2008014008A2 (en) | 2006-07-28 | 2008-01-31 | The Johns Hopkins University | Compositions and methods for modulating angiogenesis |
| CA2663962A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| AU2007299828C1 (en) * | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
| WO2008036741A2 (en) | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CA2671194A1 (en) | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| CN101622349A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-21调节的基因和途径 |
| AU2007333107A1 (en) | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-21 regulated genes and pathways as targets for therapeutic intervention |
| CA2671270A1 (en) | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| US20100298407A1 (en) | 2007-01-17 | 2010-11-25 | The Johns Hopkins University | Compositions and methods featuring micronas for treating neoplasia |
| WO2008092099A2 (en) | 2007-01-26 | 2008-07-31 | Rosetta Genomics, Ltd. | Compositions and methods for treating hematopoietic malignancies |
| US20100310583A1 (en) | 2007-01-31 | 2010-12-09 | Immune Disease Institute | Let-7 microrna and mimetics thereof as therapeutics for cancer |
| BRPI0810384B8 (pt) | 2007-04-20 | 2021-05-25 | Defiante Farm S A | terapia enzimática anticâncer |
| WO2008136971A1 (en) | 2007-04-30 | 2008-11-13 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| US8378088B2 (en) * | 2007-05-03 | 2013-02-19 | Merck Sharp & Dohme Corp. | Compositions comprising MIR34 therapeutic agents for treating cancer |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US20090232893A1 (en) | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| CN101801419A (zh) | 2007-06-08 | 2010-08-11 | 米尔纳疗法公司 | 作为治疗干预的靶标的miR-34调控的基因和路径 |
| EP2198050A1 (en) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Micrornas differentially expressed in cervical cancer and uses thereof |
| US7993831B2 (en) | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
| US20090186015A1 (en) | 2007-10-18 | 2009-07-23 | Latham Gary J | Micrornas differentially expressed in lung diseases and uses thereof |
| WO2009058907A2 (en) * | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
| US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| US20110009469A1 (en) * | 2007-12-05 | 2011-01-13 | The Johns Hopkins University | Compositions and methods of treating neoplasia |
| WO2009086156A2 (en) | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
| WO2009100430A2 (en) | 2008-02-08 | 2009-08-13 | Asuragen, Inc | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
| EP2096171A1 (en) * | 2008-02-27 | 2009-09-02 | Julius-Maximilians-Universität Würzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
| CN102015027A (zh) | 2008-02-28 | 2011-04-13 | 俄亥俄州立大学研究基金会 | 与人慢性淋巴细胞性白血病(ccl)相关的微rna特征和其用途 |
| WO2009111643A2 (en) | 2008-03-06 | 2009-09-11 | Asuragen, Inc. | Microrna markers for recurrence of colorectal cancer |
| US8361980B2 (en) * | 2008-03-07 | 2013-01-29 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microRNA related diseases |
| EP2271757A2 (en) | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Compositions and methods related to mir-16 and therapy of prostate cancer |
| WO2009126726A1 (en) | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
| EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| WO2009149418A2 (en) | 2008-06-06 | 2009-12-10 | Asuragen, Inc. | Novel compositions for the in vivo delivery of rnai agents |
| US20100090959A1 (en) | 2008-10-14 | 2010-04-15 | Sony Ericsson Mobile Communications Ab | Forming a keyboard from a combination of keys displayed on a touch sensitive display and on a separate keypad |
| US20100179213A1 (en) | 2008-11-11 | 2010-07-15 | Mirna Therapeutics, Inc. | Methods and Compositions Involving miRNAs In Cancer Stem Cells |
| JP2012515532A (ja) * | 2009-01-20 | 2012-07-12 | ラモット アット テル アビブ ユニバーシティ, リミテッド | Mir−21プロモーター駆動性標的がん治療 |
| US7665785B1 (en) | 2009-04-08 | 2010-02-23 | Newton Paul A | Column pipe catch tool |
| US8778903B2 (en) * | 2009-10-21 | 2014-07-15 | Trustees Of Dartmouth College | MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma |
| WO2011059752A1 (en) | 2009-10-28 | 2011-05-19 | Board Of Regents Of The University Of Texas System | Methods and compositions for anti-egfr treatment |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| EP2504014A4 (en) | 2009-11-24 | 2013-04-17 | Univ Western Australia | MODULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS |
| WO2011088309A1 (en) | 2010-01-14 | 2011-07-21 | Regulus Therapeutics Inc. | Microrna compositions and methods |
| WO2012041959A1 (en) | 2010-09-30 | 2012-04-05 | University Of Zurich | Treatment of b-cell lymphoma with microrna |
| CN105969773A (zh) * | 2011-02-03 | 2016-09-28 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| EP3178932A1 (en) | 2011-02-03 | 2017-06-14 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-34 |
| WO2012135728A1 (en) | 2011-03-30 | 2012-10-04 | University Of Louisville Research Foundation, Inc. | Catalytic isomerisation of linear olefinic hydrocarbons |
| HRP20170557T2 (hr) | 2011-04-25 | 2020-02-21 | Regulus Therapeutics Inc. | Mikrorna spojevi i postupci za modulaciju aktivnosti mir-21 |
| US20140351963A1 (en) | 2011-12-10 | 2014-11-27 | Ohio State Innovation Foundation | MiRNAs Useful to Reduce Lung Cancer Tumorigenesis and Chemotherapy Resistance and Related Compositions and Methods |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| AU2014228166A1 (en) | 2013-03-15 | 2015-09-24 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing micrornas and EGFR-TKI inhibitors |
| MX2015017749A (es) | 2013-06-24 | 2016-04-04 | Mirna Therapeutics Inc | Biomarcadores de actividad mir-34. |
| US20160136181A1 (en) | 2014-04-01 | 2016-05-19 | Mirna Therapeutics, Inc | Microrna dosing regimens |
-
2005
- 2005-11-14 AU AU2005333165A patent/AU2005333165B2/en not_active Ceased
- 2005-11-14 CA CA2857880A patent/CA2857880A1/en not_active Abandoned
- 2005-11-14 EP EP10183451A patent/EP2292755A1/en not_active Withdrawn
- 2005-11-14 DK DK10183577.5T patent/DK2302055T3/da active
- 2005-11-14 EP EP10183525.4A patent/EP2298894B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183596.5T patent/ES2534304T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183567.6T patent/ES2534302T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183560A patent/EP2281887A1/en not_active Withdrawn
- 2005-11-14 CA CA2857878A patent/CA2857878A1/en not_active Abandoned
- 2005-11-14 EP EP10183538.7A patent/EP2287303B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183456.2A patent/EP2292756B1/en not_active Expired - Lifetime
- 2005-11-14 JP JP2007541398A patent/JP2008519606A/ja active Pending
- 2005-11-14 EP EP14177489.3A patent/EP2808389A1/en not_active Withdrawn
- 2005-11-14 SI SI200531912T patent/SI2302055T1/sl unknown
- 2005-11-14 CA CA2850323A patent/CA2850323A1/en not_active Abandoned
- 2005-11-14 EP EP10183515A patent/EP2302053A1/en not_active Withdrawn
- 2005-11-14 WO PCT/US2005/041162 patent/WO2006137941A2/en not_active Ceased
- 2005-11-14 EP EP10183639A patent/EP2322616A1/en not_active Withdrawn
- 2005-11-14 CA CA002587189A patent/CA2587189A1/en not_active Abandoned
- 2005-11-14 US US11/273,640 patent/US8173611B2/en not_active Expired - Fee Related
- 2005-11-14 ES ES10183481.0T patent/ES2503739T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183490.1T patent/ES2534301T3/es not_active Expired - Lifetime
- 2005-11-14 CA CA2857879A patent/CA2857879A1/en not_active Abandoned
- 2005-11-14 CA CA2857881A patent/CA2857881A1/en not_active Abandoned
- 2005-11-14 EP EP10183543.7A patent/EP2314688B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183481.0A patent/EP2281886B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183589.0A patent/EP2284265B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183462.0T patent/ES2534300T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183462.0A patent/EP2302051B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183534.6T patent/ES2503741T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183538.7T patent/ES2503742T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183543.7T patent/ES2503743T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183577.5A patent/EP2302055B1/en not_active Revoked
- 2005-11-14 ES ES10183611.2T patent/ES2503765T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183456.2T patent/ES2503738T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183470A patent/EP2298893A1/en not_active Withdrawn
- 2005-11-14 CA CA2857901A patent/CA2857901A1/en not_active Abandoned
- 2005-11-14 EP EP05858321A patent/EP1838852A2/en not_active Withdrawn
- 2005-11-14 EP EP10183611.2A patent/EP2281889B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183577.5T patent/ES2507544T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183534.6A patent/EP2302054B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP14177498.4A patent/EP2808390A1/en not_active Withdrawn
- 2005-11-14 PL PL10183577T patent/PL2302055T3/pl unknown
- 2005-11-14 EP EP10183567.6A patent/EP2281888B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183525.4T patent/ES2503740T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183490.1A patent/EP2302052B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183589.0T patent/ES2534303T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183596.5A patent/EP2302056B1/en not_active Expired - Lifetime
-
2007
- 2007-08-10 US US11/837,487 patent/US8563708B2/en not_active Expired - Fee Related
- 2007-08-10 US US11/837,488 patent/US8058250B2/en not_active Expired - Fee Related
- 2007-08-10 US US11/837,490 patent/US7960359B2/en not_active Expired - Fee Related
-
2010
- 2010-02-23 JP JP2010036925A patent/JP5389690B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-25 US US13/190,232 patent/US20110313025A1/en not_active Abandoned
- 2011-11-17 US US13/299,255 patent/US8946177B2/en not_active Expired - Fee Related
-
2012
- 2012-07-05 JP JP2012150997A patent/JP5596085B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-07 US US13/761,284 patent/US20130143945A1/en not_active Abandoned
- 2013-05-03 US US13/887,008 patent/US20130303591A1/en not_active Abandoned
- 2013-08-28 US US14/012,302 patent/US8765709B2/en not_active Expired - Fee Related
- 2013-09-05 JP JP2013183871A patent/JP5620556B2/ja not_active Expired - Fee Related
-
2014
- 2014-04-16 US US14/254,532 patent/US9051571B2/en not_active Expired - Fee Related
- 2014-05-26 JP JP2014107664A patent/JP2014217381A/ja active Pending
- 2014-07-24 JP JP2014150384A patent/JP2014217386A/ja active Pending
- 2014-07-24 JP JP2014150350A patent/JP2014217385A/ja active Pending
- 2014-07-24 JP JP2014150365A patent/JP2014223080A/ja active Pending
- 2014-07-24 JP JP2014150321A patent/JP2014217384A/ja active Pending
- 2014-07-24 JP JP2014150414A patent/JP2014217387A/ja active Pending
- 2014-08-13 US US14/459,192 patent/US20140348908A1/en not_active Abandoned
- 2014-08-13 US US14/459,074 patent/US9068219B2/en not_active Expired - Fee Related
- 2014-08-13 US US14/459,182 patent/US9382537B2/en not_active Expired - Fee Related
- 2014-08-13 US US14/459,158 patent/US20150005366A1/en not_active Abandoned
- 2014-08-13 US US14/459,119 patent/US20140348907A1/en not_active Abandoned
-
2015
- 2015-05-14 US US14/712,591 patent/US9506061B2/en not_active Expired - Fee Related
- 2015-06-03 HK HK15105287.4A patent/HK1204656A1/en unknown
- 2015-06-09 US US14/735,046 patent/US20150275213A1/en not_active Abandoned
- 2015-06-12 US US14/738,716 patent/US20150284720A1/en not_active Abandoned
- 2015-06-12 US US14/738,706 patent/US20150284719A1/en not_active Abandoned
- 2015-06-12 US US14/738,646 patent/US20150342981A1/en not_active Abandoned
- 2015-06-12 US US14/738,734 patent/US20150344883A1/en not_active Abandoned
- 2015-06-12 US US14/738,728 patent/US20150299705A1/en not_active Abandoned
- 2015-06-16 US US14/741,064 patent/US9447414B2/en not_active Expired - Fee Related
- 2015-08-31 US US14/841,377 patent/US20150361431A1/en not_active Abandoned
-
2016
- 2016-03-31 JP JP2016069966A patent/JP2016165292A/ja active Pending
- 2016-10-20 US US15/298,781 patent/US20170037404A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9447414B2 (en) | Methods and compositions involving miRNA and miRNA inhibitor molecules |