DE69229482T2 - Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor - Google Patents
Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptorInfo
- Publication number
- DE69229482T2 DE69229482T2 DE69229482T DE69229482T DE69229482T2 DE 69229482 T2 DE69229482 T2 DE 69229482T2 DE 69229482 T DE69229482 T DE 69229482T DE 69229482 T DE69229482 T DE 69229482T DE 69229482 T2 DE69229482 T2 DE 69229482T2
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- human
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- antibody
- sequence
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3095476A JPH05236966A (ja) | 1991-04-25 | 1991-04-25 | ヒトインターロイキン−６レセプターに対するマウスモノクローナル抗体の可変領域をコードするｄｎａ |
| JP4032084A JPH05227970A (ja) | 1992-02-19 | 1992-02-19 | ヒトインターロイキン−６受容体に対する再構成ヒト抗体 |
| PCT/JP1992/000544 WO1992019759A1 (fr) | 1991-04-25 | 1992-04-24 | Anticorps humains reconstitues diriges contre un recepteur de l'interleukine 6 humaine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69229482D1 DE69229482D1 (de) | 1999-07-29 |
| DE69229482T2 true DE69229482T2 (de) | 1999-11-18 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69229482T Expired - Lifetime DE69229482T2 (de) | 1991-04-25 | 1992-04-24 | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
| DE122009000019C Pending DE122009000019I1 (de) | 1991-04-25 | 1992-04-24 | Rekombinierte humane antikörper gegen den humanen interleukin-6 rezeptor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE122009000019C Pending DE122009000019I1 (de) | 1991-04-25 | 1992-04-24 | Rekombinierte humane antikörper gegen den humanen interleukin-6 rezeptor |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US5795965A (show.php) |
| EP (1) | EP0628639B1 (show.php) |
| JP (6) | JP3370324B2 (show.php) |
| KR (1) | KR100249937B1 (show.php) |
| AT (1) | ATE181575T1 (show.php) |
| AU (2) | AU668349B2 (show.php) |
| DE (2) | DE69229482T2 (show.php) |
| DK (1) | DK0628639T3 (show.php) |
| ES (1) | ES2134212T3 (show.php) |
| GR (1) | GR3031174T3 (show.php) |
| HU (1) | HU218140B (show.php) |
| LU (1) | LU91556I2 (show.php) |
| NL (1) | NL300383I2 (show.php) |
| RU (1) | RU2139351C1 (show.php) |
| TW (1) | TW205553B (show.php) |
| WO (1) | WO1992019759A1 (show.php) |
Families Citing this family (338)
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| US5472693A (en) * | 1993-02-16 | 1995-12-05 | The Dow Chemical Company | Family of anti-carcinoembryonic antigen chimeric antibodies |
| TW458985B (en) * | 1993-05-31 | 2001-10-11 | Chugai Pharmaceutical Co Ltd | Reconstructed human antibody against human interleukin-6 |
| EP0714439B1 (en) * | 1993-08-24 | 2003-04-23 | Nissin Shokuhin Kabushiki Kaisha | Recombinant humanized anti-human immunodeficiency virus antibody |
| US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| EP0729976A1 (en) * | 1993-11-19 | 1996-09-04 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human medulloblastomatous cell |
| WO1995029690A1 (en) * | 1994-04-29 | 1995-11-09 | The Trustees Of The University Of Pennsylvania | Biologically active peptides and methods of identifying the same |
| US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| PT783893E (pt) | 1994-10-07 | 2012-05-24 | Chugai Pharmaceutical Co Ltd | Inibição do crescimento anormal das células sinoviais usando antagonistas de il-6 como componente ativo |
| HU225392B1 (en) * | 1994-10-21 | 2006-11-28 | Chugai Pharmaceutical Co Ltd | Use of an antibody againts interleukin-6-receptor for producing a pharmaceutical composition for treating anemia and cachexia caused by il-6 production |
| AU693318B2 (en) * | 1995-02-13 | 1998-06-25 | Chugai Seiyaku Kabushiki Kaisha | Muscle protein decomposition inhibitor containing IL-6 receptor antibody |
| US6692742B1 (en) | 1996-06-27 | 2004-02-17 | Chugai Seiyaku Kabushiki Kaisha | Remedies for myeloma to be used together with nitrogen mustard antitumor agents |
| HUP9904177A3 (en) | 1996-09-26 | 2001-10-29 | Chugai Pharmaceutical Co Ltd | Antibody against human parathormone related peptides |
| UA76934C2 (en) | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
| CN1191855C (zh) | 1997-02-12 | 2005-03-09 | 中外制药株式会社 | 淋巴细胞系肿瘤的治疗剂 |
| EP0983767B1 (en) | 1997-03-21 | 2008-09-10 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for the treatment of multiple sclerosis containing antagonist anti-IL-6-receptor antibodies |
| IL132896A0 (en) | 1997-05-15 | 2001-03-19 | Chugai Pharmaceutical Co Ltd | Cachexia remedy |
| US20020187150A1 (en) * | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| KR20040024561A (ko) * | 1997-08-15 | 2004-03-20 | 츄가이 세이야꾸 가부시키가이샤 | 항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는전신성 홍반성 낭창의 예방 및/또는 치료제 |
| DK1074268T3 (da) | 1998-03-17 | 2008-04-28 | Chugai Pharmaceutical Co Ltd | IL-6-receptorantagonistantistofholdige forebyggende eller terapeutiske midler mod inflammatoriske tarmsygdomme |
| PL343322A1 (en) | 1998-04-03 | 2001-08-13 | Chugai Pharmaceutical Co Ltd | Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody |
| WO2000010607A1 (en) * | 1998-08-24 | 2000-03-02 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for pancreatitis containing il-6 antagonists as the active ingredient |
| MXPA01005275A (es) | 1998-11-27 | 2003-06-06 | Darwin Discovery Ltd | Composiciones y metodos para aumentar la mineralizacion de huesos. |
| US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
| AU7078200A (en) * | 1999-08-27 | 2001-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use |
| ATE498305T1 (de) | 1999-10-01 | 2011-03-15 | Chugai Pharmaceutical Co Ltd | Vermeidung und behandlung von krankheiten, die mit der blutgerinnung in zusammenhang stehen |
| GB0002666D0 (en) | 2000-02-04 | 2000-03-29 | Univ London | Blockade of voltage dependent sodium channels |
| AU2001252618A1 (en) | 2000-04-28 | 2001-11-12 | Chugai Seiyaku Kabushiki Kaisha | Cell proliferation inhibitors |
| AU2001277781A1 (en) | 2000-08-11 | 2002-02-25 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing preparations |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| CN1308447C (zh) | 2000-10-20 | 2007-04-04 | 中外制药株式会社 | 低分子化的激动剂抗体 |
| EP1327681A4 (en) | 2000-10-20 | 2004-09-01 | Chugai Pharmaceutical Co Ltd | Degraded agonist antibodies |
| CN1308448C (zh) | 2000-10-20 | 2007-04-04 | 中外制药株式会社 | 低分子化的tpo激动剂抗体 |
| EP1334731B1 (en) | 2000-10-25 | 2008-02-27 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist |
| WO2002036164A1 (en) * | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient |
| AU2000279625A1 (en) * | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient |
| US7931897B2 (en) | 2001-02-07 | 2011-04-26 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for hematopoietic tumors |
| US20030044406A1 (en) * | 2001-03-02 | 2003-03-06 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents |
| ES2869895T3 (es) | 2001-03-09 | 2021-10-26 | Chugai Pharmaceutical Co Ltd | Método de purificación de proteínas |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| EP1382964A4 (en) | 2001-04-17 | 2009-06-10 | Chugai Pharmaceutical Co Ltd | METHOD FOR TENSID QUANTIFICATION |
| US7589180B2 (en) | 2001-05-11 | 2009-09-15 | Abbott Laboratories Inc. | Specific binding proteins and uses thereof |
| US20100056762A1 (en) * | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| ES2536709T3 (es) * | 2002-02-14 | 2015-05-27 | Chugai Seiyaku Kabushiki Kaisha | Utilización de ácido acético para eliminar los problemas inducidos por el ión Fe en las formulaciones de anticuerpos anti-HM1.24 o anti-IL6R |
| GB0208041D0 (en) * | 2002-04-08 | 2002-05-22 | Lonza Biologics Plc | Method of culturing animal cells |
| WO2004022597A1 (ja) | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3の血中可溶化ｎ端ﾍﾟﾌﾟﾁﾄﾞに対する抗体 |
| AU2003235948A1 (en) * | 2002-04-25 | 2003-11-10 | Chugai Seiyaku Kabushiki Kaisha | Remedy for lung cancer |
| NZ556507A (en) * | 2002-06-03 | 2010-03-26 | Genentech Inc | Synthetic antibody phage libraries |
| JP4489591B2 (ja) | 2002-08-27 | 2010-06-23 | 中外製薬株式会社 | タンパク質溶液製剤の安定化方法 |
| SI1561756T1 (sl) | 2002-09-11 | 2016-02-29 | Chugai Seiyaku Kabushiki Kaisha | Postopek čiščenja proteinov |
| JP4555924B2 (ja) * | 2003-02-24 | 2010-10-06 | 中外製薬株式会社 | インターロイキン−６アンタゴニストを含有する脊髄損傷治療剤 |
| JP2004279086A (ja) | 2003-03-13 | 2004-10-07 | Konica Minolta Holdings Inc | 放射線画像変換パネル及び放射線画像変換パネルの製造方法 |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| CA2529623A1 (en) * | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
| ATE490787T1 (de) | 2003-07-15 | 2010-12-15 | Chugai Pharmaceutical Co Ltd | Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion |
| MXPA06003768A (es) | 2003-10-17 | 2006-06-23 | Chugai Pharmaceutical Co Ltd | Agente terapeutico para el mesotelioma. |
| AU2004295590B2 (en) | 2003-12-03 | 2010-04-29 | Chugai Seiyaku Kabushiki Kaisha | Expression systems using mammalian beta-actin promoter |
| AR048210A1 (es) | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
| US8617550B2 (en) | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
| ES2341461T5 (es) * | 2004-02-11 | 2014-10-29 | Warner-Lambert Company Llc | Procedimientos de tratamiento de la artrosis con anticuerpos ANTI-IL-6 |
| WO2005079479A2 (en) * | 2004-02-17 | 2005-09-01 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
| US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| EP1728801A4 (en) * | 2004-03-24 | 2009-10-21 | Chugai Pharmaceutical Co Ltd | SUBTYP OF A HUMANIZED ANTIBODY AGAINST THE INTERLEUKIN-6 RECEPTOR |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
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| WO2024107752A2 (en) | 2022-11-15 | 2024-05-23 | Onestone Therapeutics Llc | Compositions and methods for immunomodulatory bifunctional fusion molecules |
| WO2024204671A1 (ja) | 2023-03-31 | 2024-10-03 | 国立大学法人大阪大学 | 敗血症患者の予後を予測するためのバイオマーカーおよびその使用 |
| CN121038814A (zh) | 2023-04-14 | 2025-11-28 | 中外制药株式会社 | 用于稳定含蛋白质药物制剂的方法 |
| WO2025198912A1 (en) | 2024-03-21 | 2025-09-25 | Hoffmann-La Roche Inc. | Methods of treating myasthenia gravis |
| HUP2400216A1 (hu) | 2024-04-17 | 2025-10-28 | Richter Gedeon Nyrt | N-terminális glutamint tartalmazó immunglobulinok tisztítására szolgáló eljárások |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4304583A (en) * | 1980-06-02 | 1981-12-08 | Corning Glass Works | Process for drying optical waveguide preforms |
| JPS6147500A (ja) * | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| GB8422238D0 (en) * | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5082782A (en) | 1988-12-27 | 1992-01-21 | Worcester Polytechnic Institute | Production of horseshoe crab amebocytes in vitro |
| IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5216128A (en) * | 1989-06-01 | 1993-06-01 | Yeda Research And Development Co., Ltd. | IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it |
| JP2998976B2 (ja) * | 1989-07-20 | 2000-01-17 | 忠三 岸本 | ヒトインタ―ロイキン―６レセプターに対する抗体 |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| FR2943539B1 (fr) | 2009-03-31 | 2011-07-22 | Ethypharm Sa | Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus. |
| EP2409607A1 (de) | 2010-07-20 | 2012-01-25 | Josef Kurz | Schuhlöffel |
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1992
- 1992-04-24 WO PCT/JP1992/000544 patent/WO1992019759A1/ja not_active Ceased
- 1992-04-24 DE DE69229482T patent/DE69229482T2/de not_active Expired - Lifetime
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- 1992-04-24 EP EP92909376A patent/EP0628639B1/en not_active Expired - Lifetime
- 1992-04-24 DE DE122009000019C patent/DE122009000019I1/de active Pending
- 1992-04-24 ES ES92909376T patent/ES2134212T3/es not_active Expired - Lifetime
- 1992-04-24 JP JP50889892A patent/JP3370324B2/ja not_active Expired - Lifetime
- 1992-04-24 TW TW081103237A patent/TW205553B/zh active
- 1992-04-24 DK DK92909376T patent/DK0628639T3/da active
- 1992-04-24 KR KR1019930703229A patent/KR100249937B1/ko not_active Expired - Lifetime
- 1992-04-24 HU HU9303002A patent/HU218140B/hu active Protection Beyond IP Right Term
- 1992-04-24 US US08/137,117 patent/US5795965A/en not_active Expired - Lifetime
- 1992-04-24 AT AT92909376T patent/ATE181575T1/de active
- 1992-04-24 RU RU93055358A patent/RU2139351C1/ru active Protection Beyond IP Right Term
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1995
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1996
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1999
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- 1999-11-29 JP JP33828699A patent/JP3176598B2/ja not_active Expired - Lifetime
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2000
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2003
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2004
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2006
- 2006-12-15 JP JP2006338832A patent/JP2007082560A/ja not_active Withdrawn
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2007
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2009
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