DE69129896T2 - Gegen cd3 gerichtete antikörper - Google Patents
Gegen cd3 gerichtete antikörperInfo
- Publication number
- DE69129896T2 DE69129896T2 DE69129896T DE69129896T DE69129896T2 DE 69129896 T2 DE69129896 T2 DE 69129896T2 DE 69129896 T DE69129896 T DE 69129896T DE 69129896 T DE69129896 T DE 69129896T DE 69129896 T2 DE69129896 T2 DE 69129896T2
- Authority
- DE
- Germany
- Prior art keywords
- ser
- tyr
- gly
- asp
- asn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909021679A GB9021679D0 (en) | 1990-10-05 | 1990-10-05 | Antibody preparation |
PCT/GB1991/001726 WO1992006193A1 (en) | 1990-10-05 | 1991-10-04 | Antibodies directed against cd3 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69129896D1 DE69129896D1 (de) | 1998-09-03 |
DE69129896T2 true DE69129896T2 (de) | 1998-12-10 |
Family
ID=10683287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69129896T Expired - Lifetime DE69129896T2 (de) | 1990-10-05 | 1991-10-04 | Gegen cd3 gerichtete antikörper |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0504350B1 (de) |
JP (1) | JP3081641B2 (de) |
KR (1) | KR100245564B1 (de) |
AT (1) | ATE169058T1 (de) |
AU (1) | AU651623B2 (de) |
CA (1) | CA2070659C (de) |
DE (1) | DE69129896T2 (de) |
ES (1) | ES2121788T3 (de) |
GB (2) | GB9021679D0 (de) |
NZ (1) | NZ240080A (de) |
WO (1) | WO1992006193A1 (de) |
ZA (1) | ZA917960B (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9021679D0 (en) * | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
US6106835A (en) * | 1991-04-19 | 2000-08-22 | Tanox, Inc. | Modified binding molecules specific for T or B lymphocytes and their use as in vivo immune modulators |
US6129916A (en) * | 1991-04-19 | 2000-10-10 | Tanox, Inc. | Method of Increasing activation on proliferation of T cells using antibody-microbead conjugates |
US6197298B1 (en) | 1991-04-19 | 2001-03-06 | Tanox, Inc. | Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals |
CA2065658A1 (en) * | 1991-04-19 | 1992-10-20 | Tse-Wen Chang | Conjugates of liposomes or microbeads and antibodies specific for t lymphocytes and their use in vivo immune modulators |
US5872222A (en) * | 1991-04-19 | 1999-02-16 | Tanox Biosystems, Inc. | Conjugates of polymers and antibodies specific for T lymphocytes, and their use as adjuvants |
US5817308A (en) | 1994-02-14 | 1998-10-06 | University Of Rochester | Tolerogenic fusion proteins of immunoglobulins and methods for inducing and maintaining tolerance |
US7175847B1 (en) | 1995-06-07 | 2007-02-13 | Biogen Idec Inc. | Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4 |
US6113898A (en) | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
US7153508B2 (en) | 1995-06-07 | 2006-12-26 | Biogen Idec Inc. | Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4 |
JP4566290B2 (ja) | 1997-04-30 | 2010-10-20 | ツインストランド・ホールディングス・インコーポレイテッド | 癌、ウイルスまたは寄生虫感染を治療するためのリシン様毒素変異体 |
US6103466A (en) * | 1997-07-14 | 2000-08-15 | University Of Liege | Double-muscling in mammals |
PT2045322E (pt) | 1997-07-14 | 2015-10-16 | Université de Liège | Musculatura dupla em mamíferos |
GB9815909D0 (en) | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
US6531125B1 (en) | 1999-03-02 | 2003-03-11 | Twinstrand Therapeutics Inc. | Antiviral ricin-like proteins |
CA2305716A1 (en) | 1999-05-28 | 2000-11-28 | University Of Guelph | Method for assay of wbpm |
US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
EP1499635B8 (de) | 2002-05-02 | 2014-04-16 | David Lovejoy | Teneurin c-terminal assoziierte peptide und deren verwendungen |
US7871768B2 (en) | 2003-08-04 | 2011-01-18 | The Hospital For Sick Children | Lafora's disease gene |
CA2494572A1 (en) | 2003-12-19 | 2005-06-19 | Cytochroma Inc. | Cytochrome p450 24 (cyp24) monoclonal antibody and methods and uses thereof |
US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
EP1848462B1 (de) | 2005-02-16 | 2011-10-26 | University of Zürich | Verfahren zur behandlung von krebs unter verwendung eines immunotoxins mit einer exotoxin-a-gruppierung, bei der eine furinschnittstelle durch eine von mmp-2 oder mmp-9 gespaltene krebsassoziierte proteasestelle ersetzt ist |
TW200744634A (en) | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
TWI417301B (zh) | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-22(il-22)之抗體及其用途 |
CA2657248C (en) | 2006-07-13 | 2018-10-30 | Wyeth | Production of glycoproteins |
MX2009003306A (es) * | 2006-10-02 | 2009-04-23 | Medarex Inc | Anticuerpos humanos que se unen a cxcr4 y sus usos. |
RU2009111138A (ru) | 2006-10-12 | 2010-11-20 | Вайет (Us) | Способы и композиции с уменьшенной опалесценцией |
CA2666317C (en) | 2006-11-03 | 2013-08-06 | Wyeth | Glycolysis-inhibiting substances in cell culture |
US20110294782A1 (en) | 2006-11-10 | 2011-12-01 | Massachusetts Institute Of Technology | Small molecule pak inhibitors |
DE102006062398A1 (de) | 2006-12-20 | 2008-06-26 | Edi (Experimentelle & Diagnostische Immunologie) Gmbh | Verfahren zur Erkennung und/oder Charakterisierung zellulärer Aktivitätsmuster, Verwendung von Toll-like-Rezeptor-Liganden (TLR-Liganden) und ein Kit |
DK2115126T3 (en) | 2007-03-02 | 2015-05-04 | Wyeth Llc | Use of copper and glutamate in cell culture for the preparation of polypeptides |
JP2012504939A (ja) | 2008-09-23 | 2012-03-01 | ワイス・エルエルシー | 架橋結合タンパク質による活性化シグナルの産生を予測するための方法 |
EP3011953A1 (de) | 2008-10-29 | 2016-04-27 | Ablynx N.V. | Stabilizierte formulierungen von einzeldomänen-antigen-bindenden molekülen |
WO2010056550A1 (en) | 2008-10-29 | 2010-05-20 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
US9085795B2 (en) | 2009-02-04 | 2015-07-21 | Molecular Innovations, Inc. | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies |
AU2010241706B2 (en) | 2009-04-29 | 2015-07-09 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | ERG monoclonal antibodies |
US20120226119A1 (en) | 2009-07-09 | 2012-09-06 | Hoffmann-La Roche Inc. | Vivo tumor vasculature imaging |
KR101831459B1 (ko) | 2010-03-03 | 2018-04-04 | 더 유니버시티 오브 브리티시 콜롬비아 | 올리고머 특이적 아밀로이드 베타 에피토프 및 항체 |
AU2011277983C1 (en) | 2010-07-16 | 2016-09-29 | Ablynx Nv | Modified single domain antigen binding molecules and uses thereof |
EP2420250A1 (de) | 2010-08-13 | 2012-02-22 | Universitätsklinikum Münster | Anti-Syndecan-4-Antikörper |
CA2807607A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
JP2014500879A (ja) | 2010-11-16 | 2014-01-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
CN106039306A (zh) | 2011-03-30 | 2016-10-26 | 埃博灵克斯股份有限公司 | 使用针对TNFα的单结构域抗体治疗免疫病症的方法 |
SG11201401220SA (en) | 2011-10-21 | 2014-07-30 | Pfizer | Addition of iron to improve cell culture |
CA2883569A1 (en) | 2012-08-31 | 2014-03-06 | University Of Virginia Patent Foundation | Target peptides for immunotherapy and diagnostics |
WO2014039675A2 (en) | 2012-09-05 | 2014-03-13 | University Of Virginia Patent Foundation | Target peptides for colorectal cancer therapy and diagnostics |
EP3677310A1 (de) | 2012-10-08 | 2020-07-08 | St. Jude Children's Research Hospital | Therapien auf der basis der steuerung der stabilität und funktion regulatorischer t-zellen über eine neuropilin-1:semaphorin-achse |
EP3756687A3 (de) | 2012-12-13 | 2021-03-24 | University Of Virginia Patent Foundation | Target-peptide für therapie und diagnostik von ovarialkarzinom |
EP4067383A1 (de) | 2013-07-25 | 2022-10-05 | Cytomx Therapeutics Inc. | Multispezifische antikörper, aktivierbare multispezifische antikörper und verfahren zur verwendung davon |
EP3119876A1 (de) | 2014-03-19 | 2017-01-25 | Pfizer Inc. | Verfahren zur zellkultur |
AU2015247727A1 (en) | 2014-04-15 | 2016-11-03 | University Of Virginia Patent Foundation | Isolated T cell receptors and methods of use therefor |
CN107108738A (zh) | 2014-07-25 | 2017-08-29 | 西托姆克斯治疗公司 | 抗cd3抗体、可活化抗cd3抗体、多特异性抗cd3抗体、多特异性可活化抗cd3抗体及其使用方法 |
MA45352A (fr) | 2015-08-07 | 2018-06-13 | Univ Birmingham | Identification de glycopeptides associés à mhc de catégorie i comme cibles d'immunothérapie de cancer |
WO2017051347A2 (en) | 2015-09-23 | 2017-03-30 | Pfizer Inc. | Cells and method of cell culture |
GB201520191D0 (en) | 2015-11-16 | 2015-12-30 | Cancer Rec Tech Ltd | T-cell receptor and uses thereof |
EP3440190A1 (de) | 2016-04-05 | 2019-02-13 | Pfizer Inc | Zellkulturverfahren |
RU2756236C2 (ru) | 2016-06-20 | 2021-09-28 | Кимаб Лимитед | PD-L1 специфические антитела |
JP7177076B2 (ja) | 2017-03-16 | 2022-11-22 | ファイザー・インク | チロシン原栄養性 |
CA3063344A1 (en) | 2017-05-23 | 2018-11-29 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Novel cd73 antibody, preparation and uses thereof |
KR20200047702A (ko) | 2017-09-15 | 2020-05-07 | 브리스톨-마이어스 스큅 컴퍼니 | 관심 폴리펩티드 대규모 생산 동안의 온라인 바이오매스 정전용량 모니터링 |
EP3743101A2 (de) | 2018-01-25 | 2020-12-02 | ACM Biolabs Pte Ltd | Ein lösliches verkapseltes antigen enthaltende polymersome sowie verfahren zu deren herstellung und verwendung |
US20210010055A1 (en) | 2018-03-16 | 2021-01-14 | Bristol-Myers Squibb Company | Metabolic enzyme activity and disulfide bond reduction during protein production |
WO2019185515A1 (en) | 2018-03-26 | 2019-10-03 | Glycanostics S.R.O. | Means and methods for glycoprofiling of a protein |
US20220105176A1 (en) | 2018-09-12 | 2022-04-07 | Acm Biolabs Pte Ltd | Polymersomes comprising a covalently bound antigen as well as methods of making and uses thereof |
WO2020115655A1 (en) | 2018-12-06 | 2020-06-11 | Pfizer Inc. | Cells with reduced inhibitor production and methods of use thereof |
US20220332799A1 (en) | 2019-09-04 | 2022-10-20 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) | Herv inhibitors for use in treating tauopathies |
WO2022218957A1 (en) | 2021-04-12 | 2022-10-20 | Acm Biolabs Pte Ltd | Polymersomes comprising a soluble encapsulated polynucleotide and an ionizable lipid as well as methods of making and uses thereof |
WO2023025927A1 (en) | 2021-08-26 | 2023-03-02 | Glycanostics S.R.O | Glycoprotein biomarkers for diagnosing cancer |
KR20240053007A (ko) | 2021-09-14 | 2024-04-23 | 글리카노스틱스 에스.알.오. | 유방암 진단을 위한 당단백질 바이오마커 |
WO2023079058A1 (en) | 2021-11-05 | 2023-05-11 | Yokogawa Insilico Biotechnology Gmbh | Cell culture with reduced production of lactate |
WO2023148598A1 (en) | 2022-02-02 | 2023-08-10 | Pfizer Inc. | Cysteine prototrophy |
CN115073602B (zh) * | 2022-05-30 | 2023-10-03 | 苏州百道医疗科技有限公司 | 一种抗cd3重组兔单克隆抗体及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI105320B (fi) * | 1988-04-04 | 2000-07-31 | Oncogen | Menetelmä vasta-aineheterokonjugaattien valmistamiseksi, joita käytetään imusoluaktiivisuuden säätelyssä ja diagnoosissa |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9021679D0 (en) * | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
-
1990
- 1990-10-05 GB GB909021679A patent/GB9021679D0/en active Pending
-
1991
- 1991-10-03 NZ NZ240080A patent/NZ240080A/en not_active IP Right Cessation
- 1991-10-04 CA CA002070659A patent/CA2070659C/en not_active Expired - Lifetime
- 1991-10-04 ES ES91917169T patent/ES2121788T3/es not_active Expired - Lifetime
- 1991-10-04 KR KR1019920701339A patent/KR100245564B1/ko not_active IP Right Cessation
- 1991-10-04 JP JP03516117A patent/JP3081641B2/ja not_active Expired - Fee Related
- 1991-10-04 AU AU85468/91A patent/AU651623B2/en not_active Expired
- 1991-10-04 DE DE69129896T patent/DE69129896T2/de not_active Expired - Lifetime
- 1991-10-04 ZA ZA917960A patent/ZA917960B/xx unknown
- 1991-10-04 EP EP91917169A patent/EP0504350B1/de not_active Expired - Lifetime
- 1991-10-04 GB GB9121126A patent/GB2249310B/en not_active Revoked
- 1991-10-04 WO PCT/GB1991/001726 patent/WO1992006193A1/en active IP Right Grant
- 1991-10-04 AT AT91917169T patent/ATE169058T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB2249310A (en) | 1992-05-06 |
GB9121126D0 (en) | 1991-11-13 |
KR100245564B1 (ko) | 2000-02-15 |
JPH05502384A (ja) | 1993-04-28 |
WO1992006193A1 (en) | 1992-04-16 |
ES2121788T3 (es) | 1998-12-16 |
CA2070659A1 (en) | 1992-04-06 |
JP3081641B2 (ja) | 2000-08-28 |
DE69129896D1 (de) | 1998-09-03 |
ZA917960B (en) | 1993-04-05 |
KR927003816A (ko) | 1992-12-18 |
AU651623B2 (en) | 1994-07-28 |
EP0504350A1 (de) | 1992-09-23 |
ATE169058T1 (de) | 1998-08-15 |
GB2249310B (en) | 1994-08-03 |
GB9021679D0 (en) | 1990-11-21 |
CA2070659C (en) | 2001-04-24 |
AU8546891A (en) | 1992-04-28 |
NZ240080A (en) | 1995-05-26 |
EP0504350B1 (de) | 1998-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |