ES2121788T3 - Anticuerpos dirigidos contra cd3. - Google Patents

Anticuerpos dirigidos contra cd3.

Info

Publication number
ES2121788T3
ES2121788T3 ES91917169T ES91917169T ES2121788T3 ES 2121788 T3 ES2121788 T3 ES 2121788T3 ES 91917169 T ES91917169 T ES 91917169T ES 91917169 T ES91917169 T ES 91917169T ES 2121788 T3 ES2121788 T3 ES 2121788T3
Authority
ES
Spain
Prior art keywords
ser
tyr
gly
asp
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917169T
Other languages
English (en)
Inventor
Scott David Gorman
Edward Graham Routledge
Herman Waldmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Application granted granted Critical
Publication of ES2121788T3 publication Critical patent/ES2121788T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LIGANTES CON UNA AFINIDAD DE ENLACE PARA EL ANTIGENO CD3 QUE TIENEN, AL MENOS, UN CDR CUYO ORIGEN ES DISTINTO RESPECTO A LA REGION DE LA ESTRUCTURA VARIABLE Y/O A LA REGION CONSTANTE DEL LIGANTE; AL MENOS, EL UNICO CDR QUE SE SELECCIONA DE LAS SECUENCIAS DE AMINOACIDOS: (A) SER TR ARG ASN LIS FE DE LOS MISMOS, TIENEN VALOR TERAPEUTICO, PARTICULARMENTE EN EL CONTROL DEL RECHAZO A INJERTOS.
ES91917169T 1990-10-05 1991-10-04 Anticuerpos dirigidos contra cd3. Expired - Lifetime ES2121788T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909021679A GB9021679D0 (en) 1990-10-05 1990-10-05 Antibody preparation

Publications (1)

Publication Number Publication Date
ES2121788T3 true ES2121788T3 (es) 1998-12-16

Family

ID=10683287

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917169T Expired - Lifetime ES2121788T3 (es) 1990-10-05 1991-10-04 Anticuerpos dirigidos contra cd3.

Country Status (12)

Country Link
EP (1) EP0504350B1 (es)
JP (1) JP3081641B2 (es)
KR (1) KR100245564B1 (es)
AT (1) ATE169058T1 (es)
AU (1) AU651623B2 (es)
CA (1) CA2070659C (es)
DE (1) DE69129896T2 (es)
ES (1) ES2121788T3 (es)
GB (2) GB9021679D0 (es)
NZ (1) NZ240080A (es)
WO (1) WO1992006193A1 (es)
ZA (1) ZA917960B (es)

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GB9021679D0 (en) * 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation

Also Published As

Publication number Publication date
GB2249310A (en) 1992-05-06
DE69129896D1 (de) 1998-09-03
EP0504350B1 (en) 1998-07-29
JP3081641B2 (ja) 2000-08-28
NZ240080A (en) 1995-05-26
GB9121126D0 (en) 1991-11-13
CA2070659A1 (en) 1992-04-06
AU651623B2 (en) 1994-07-28
KR100245564B1 (ko) 2000-02-15
GB2249310B (en) 1994-08-03
GB9021679D0 (en) 1990-11-21
CA2070659C (en) 2001-04-24
KR927003816A (ko) 1992-12-18
JPH05502384A (ja) 1993-04-28
AU8546891A (en) 1992-04-28
DE69129896T2 (de) 1998-12-10
WO1992006193A1 (en) 1992-04-16
ATE169058T1 (de) 1998-08-15
ZA917960B (en) 1993-04-05
EP0504350A1 (en) 1992-09-23

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