ATE169058T1 - Gegen cd3 gerichtete antikörper - Google Patents

Gegen cd3 gerichtete antikörper

Info

Publication number
ATE169058T1
ATE169058T1 AT91917169T AT91917169T ATE169058T1 AT E169058 T1 ATE169058 T1 AT E169058T1 AT 91917169 T AT91917169 T AT 91917169T AT 91917169 T AT91917169 T AT 91917169T AT E169058 T1 ATE169058 T1 AT E169058T1
Authority
AT
Austria
Prior art keywords
ser
tyr
gly
asp
asn
Prior art date
Application number
AT91917169T
Other languages
English (en)
Inventor
Scott David Gorman
Edward Graham Routledge
Herman Waldmann
Original Assignee
British Tech Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Tech Group filed Critical British Tech Group
Application granted granted Critical
Publication of ATE169058T1 publication Critical patent/ATE169058T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
AT91917169T 1990-10-05 1991-10-04 Gegen cd3 gerichtete antikörper ATE169058T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909021679A GB9021679D0 (en) 1990-10-05 1990-10-05 Antibody preparation

Publications (1)

Publication Number Publication Date
ATE169058T1 true ATE169058T1 (de) 1998-08-15

Family

ID=10683287

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91917169T ATE169058T1 (de) 1990-10-05 1991-10-04 Gegen cd3 gerichtete antikörper

Country Status (12)

Country Link
EP (1) EP0504350B1 (de)
JP (1) JP3081641B2 (de)
KR (1) KR100245564B1 (de)
AT (1) ATE169058T1 (de)
AU (1) AU651623B2 (de)
CA (1) CA2070659C (de)
DE (1) DE69129896T2 (de)
ES (1) ES2121788T3 (de)
GB (2) GB9021679D0 (de)
NZ (1) NZ240080A (de)
WO (1) WO1992006193A1 (de)
ZA (1) ZA917960B (de)

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GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9021679D0 (en) * 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation

Also Published As

Publication number Publication date
JP3081641B2 (ja) 2000-08-28
JPH05502384A (ja) 1993-04-28
KR100245564B1 (ko) 2000-02-15
WO1992006193A1 (en) 1992-04-16
DE69129896T2 (de) 1998-12-10
AU651623B2 (en) 1994-07-28
GB2249310B (en) 1994-08-03
CA2070659A1 (en) 1992-04-06
CA2070659C (en) 2001-04-24
GB9121126D0 (en) 1991-11-13
GB2249310A (en) 1992-05-06
NZ240080A (en) 1995-05-26
GB9021679D0 (en) 1990-11-21
AU8546891A (en) 1992-04-28
EP0504350A1 (de) 1992-09-23
ZA917960B (en) 1993-04-05
DE69129896D1 (de) 1998-09-03
KR927003816A (ko) 1992-12-18
ES2121788T3 (es) 1998-12-16
EP0504350B1 (de) 1998-07-29

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Legal Events

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UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time