ATE490787T1 - Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion - Google Patents
Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktionInfo
- Publication number
- ATE490787T1 ATE490787T1 AT04747833T AT04747833T ATE490787T1 AT E490787 T1 ATE490787 T1 AT E490787T1 AT 04747833 T AT04747833 T AT 04747833T AT 04747833 T AT04747833 T AT 04747833T AT E490787 T1 ATE490787 T1 AT E490787T1
- Authority
- AT
- Austria
- Prior art keywords
- igm
- production
- quantifying
- transformed cells
- chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48733303P | 2003-07-15 | 2003-07-15 | |
| PCT/JP2004/010444 WO2005005636A1 (ja) | 2003-07-15 | 2004-07-15 | 形質転換細胞によるIgMの産生とその定量方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490787T1 true ATE490787T1 (de) | 2010-12-15 |
Family
ID=34062150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04747833T ATE490787T1 (de) | 2003-07-15 | 2004-07-15 | Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7709615B2 (de) |
| EP (2) | EP1652925B1 (de) |
| JP (1) | JP5452835B2 (de) |
| AT (1) | ATE490787T1 (de) |
| AU (1) | AU2004256354B2 (de) |
| CA (1) | CA2532966C (de) |
| DE (1) | DE602004030451D1 (de) |
| TW (1) | TW200510532A (de) |
| WO (1) | WO2005005636A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE490787T1 (de) | 2003-07-15 | 2010-12-15 | Chugai Pharmaceutical Co Ltd | Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion |
| US7803914B2 (en) | 2003-10-09 | 2010-09-28 | Chugai Seiyaku Kabushiki Kaisha | Methods for stabilizing protein solutions |
| WO2005035574A1 (ja) | 2003-10-09 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | IgM高濃度安定化溶液 |
| JP4818936B2 (ja) * | 2005-01-05 | 2011-11-16 | 中外製薬株式会社 | 細胞の培養方法およびその利用 |
| EP1898938A4 (de) * | 2005-06-27 | 2010-01-27 | Life Technologies Corp | Flüssige proteinmarker für die native gelelektrophorese |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| US9084777B2 (en) | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
| WO2007106617A2 (en) * | 2006-01-30 | 2007-09-20 | Talecris Biotherapeutics, Inc. | Method of treatment and prophylaxis of diseases related to amyloid deposition using igm |
| WO2007142325A1 (ja) | 2006-06-08 | 2007-12-13 | Chugai Seiyaku Kabushiki Kaisha | 炎症性疾患の予防または治療剤 |
| HU0700534D0 (en) | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
| JP4976502B2 (ja) | 2007-10-15 | 2012-07-18 | 中外製薬株式会社 | 抗体の製造方法 |
| CN104162155A (zh) | 2007-12-05 | 2014-11-26 | 中外制药株式会社 | 搔痒症治疗药 |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| US8278065B2 (en) | 2008-06-30 | 2012-10-02 | Morphotek, Inc. | Polynucleotides encoding anti-GD2 antibodies |
| US8691514B2 (en) * | 2008-10-31 | 2014-04-08 | Japan Science And Technology Agency | Method for selective control of helper T cell function |
| AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
| US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
| KR101993488B1 (ko) | 2011-09-01 | 2019-06-26 | 추가이 세이야쿠 가부시키가이샤 | 한외여과에 의해 고도로 농축된 항체를 포함하는 조성물의 제조 방법 |
| EP3305323B1 (de) * | 2012-04-17 | 2021-02-17 | Mayo Foundation for Medical Education and Research | Menschliche antikörper und spezifische bindungssequenzen davon zur verwendung bei apoplexie und ischämie oder ischämischen zuständen |
| WO2014083006A1 (en) * | 2012-11-30 | 2014-06-05 | Katinger Gmbh | RECOMBINANT HUMAN IgM-ANTIBODY EFFECTIVE AGAINST CANCER CELLS |
| US20140199319A1 (en) * | 2012-12-14 | 2014-07-17 | Abbvie, Inc. | Methods for increasing the efficiency of hybridoma generation |
| BR112016014824A2 (pt) | 2013-12-27 | 2017-09-19 | Chugai Pharmaceutical Co Ltd | Método para purificar anticorpo que tem ponto isoelétrico baixo |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| JP6858559B2 (ja) | 2014-08-20 | 2021-04-14 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) * | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Cd20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) * | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| EP3356401B1 (de) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Bindungsmoleküle mit modifizierter j-kette |
| EP3824903A1 (de) | 2015-09-30 | 2021-05-26 | IGM Biosciences Inc. | Bindungsmoleküle mit modifizierter j-kette |
| US10572893B2 (en) | 2016-06-16 | 2020-02-25 | International Business Machines Corporation | Discovering and interacting with proximate automobiles |
| CN112512480B (zh) | 2018-05-21 | 2024-10-01 | 中外制药株式会社 | 被封入玻璃容器的冷冻干燥制剂 |
| CN112243423B (zh) | 2018-05-28 | 2022-11-04 | 中外制药株式会社 | 填充喷嘴 |
| WO2021022113A1 (en) * | 2019-07-31 | 2021-02-04 | The Wistar Institute Of Anatomy And Biology | Multivalent dna antibody constructs and use thereof |
| BR112022021392A2 (pt) * | 2020-04-22 | 2022-12-06 | Igm Biosciences Inc | Moléculas de ligação multiméricas de agonista de pd-1 |
| EP4297786A4 (de) * | 2021-02-23 | 2025-01-22 | Pandion Operations, Inc. | Pd-1-antikörper, polypeptide und verwendungen davon |
| WO2023244276A2 (en) * | 2021-10-13 | 2023-12-21 | The Wistar Institute Of Anatomy And Biology | DNA ENCODED ANTIBODIES WITH Fc MODIFICATIONS |
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| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| US5157113A (en) | 1987-08-10 | 1992-10-20 | Miles Inc. | Removal of nucleic acids from monoclonal antibody preparations |
| ATE82136T1 (de) | 1987-08-10 | 1992-11-15 | Miles Inc | Gereinigtes igm. |
| GB8719963D0 (en) | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| US6238891B1 (en) | 1987-11-18 | 2001-05-29 | Cetus Oncology Corporation | Method of increasing product expression through solute stress |
| CA1312030C (en) | 1987-11-18 | 1992-12-29 | Brian Maiorella | Method to increase antibody titer |
| JP2501116B2 (ja) | 1988-03-05 | 1996-05-29 | 日本電信電話株式会社 | 巡回制御形回線交換方法 |
| DE3825429C2 (de) | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| GB9010944D0 (en) | 1990-05-16 | 1990-07-04 | Central Blood Lab Authority | Chemical compounds |
| US5419904A (en) * | 1990-11-05 | 1995-05-30 | The Regents Of The University Of California | Human B-lymphoblastoid cell line secreting anti-ganglioside antibody |
| EP0492409A1 (de) * | 1990-12-18 | 1992-07-01 | Ishihara Sangyo Kaisha, Ltd. | Menschlicher monoklonaler Antikörper |
| JPH05192181A (ja) | 1990-12-18 | 1993-08-03 | Ishihara Sangyo Kaisha Ltd | ヒトモノクローナル抗体 |
| JPH0565233A (ja) | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
| CA2081028C (en) * | 1991-03-12 | 1999-12-14 | Barbara P. Wallner | Cd2 binding domain of lymphocyte function associated antigen 3 |
| EP0628639B1 (de) | 1991-04-25 | 1999-06-23 | Chugai Seiyaku Kabushiki Kaisha | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
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| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| JP3565572B2 (ja) | 1992-09-07 | 2004-09-15 | 協和醗酵工業株式会社 | ヒト化抗体 |
| CA2105618C (en) * | 1992-09-07 | 2009-11-03 | Kazuyasu Nakamura | Humanized antibodies to ganglioside gm2 |
| JPH06178689A (ja) * | 1992-12-11 | 1994-06-28 | Mitsui Toatsu Chem Inc | I型緑膿菌を抗原とするヒト抗体をコードする遺伝子 |
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| JPH09127112A (ja) | 1995-10-30 | 1997-05-16 | Dainabotsuto Kk | 修飾IgM免疫学的測定試薬 |
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| ES2221065T3 (es) * | 1996-08-16 | 2004-12-16 | The President And Fellows Of Harvard College | Proteinas de fusion de clase ii del mhc, solubles, monovalentes o polivalentes, y sus usos. |
| EP0835880A1 (de) | 1996-10-14 | 1998-04-15 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation |
| JPH10324699A (ja) * | 1997-03-21 | 1998-12-08 | Sankyo Co Ltd | 抗ヒトFasヒト化抗体 |
| ZA988461B (en) | 1997-09-18 | 1999-03-30 | Idec Pharma Corp | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis |
| AU3544599A (en) | 1998-01-16 | 1999-08-02 | Paul E. Borchardt | Use of radiolabeled monoclonal igm in therapy for cancer and autoimmune disease |
| AU2444899A (en) | 1998-01-22 | 1999-08-09 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
| NZ506071A (en) * | 1998-02-19 | 2003-05-30 | Harvard College | Monovalent, multivalent, and multimeric major histocompatibility complex (MHC) binding domain fusion proteins and conjugates, and uses therefore |
| JP2000154149A (ja) * | 1998-09-18 | 2000-06-06 | Sankyo Co Ltd | 抗ヒトFasヒト化抗体含有抗リウマチ剤 |
| DK1121382T3 (da) * | 1998-10-16 | 2006-11-13 | Biogen Idec Inc | Interferon-beta-fusionsproteiner og deres anvendelser |
| EP1176195B1 (de) | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Verfahren zur kontrolle der aktivität von immunologisch funktionellem molekül |
| CA2371427A1 (en) | 1999-04-28 | 2000-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Parenteral pharmaceutical composition containing humanized monoclonal antibody fragment and stabilizing method thereof |
| WO2001023431A1 (fr) | 1999-09-30 | 2001-04-05 | Kyowa Hakko Kogyo Co., Ltd. | Derives d'anticorps contre le ganglioside gm2 |
| EP1226752A4 (de) | 1999-11-05 | 2004-05-06 | Kyowa Hakko Kogyo Kk | Transgene nicht-humane tiere zur überwachung einer veränderung der kalzium-ionenkonzentration in zellen |
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| WO2002003430A2 (en) | 2000-06-29 | 2002-01-10 | California Institute Of Technology | Aerosol process for fabricating discontinuous floating gate microelectronic devices |
| US20040081972A1 (en) | 2000-08-01 | 2004-04-29 | Mitsuo Satoh | Novel physiologically active peptide and use thereof |
| GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| JP2003128576A (ja) * | 2001-10-25 | 2003-05-08 | Taisho Pharmaceut Co Ltd | エンドトキシン誘発性疾患治療薬 |
| WO2003046162A2 (en) | 2001-11-28 | 2003-06-05 | Polymun Scientific Immunbiologische Forschung Gmbh | Process for the production of polypeptides in mammalian cell cultures |
| DE10328295B4 (de) | 2003-06-23 | 2007-11-22 | Endress + Hauser Gmbh + Co. Kg | Verfahren und entsprechende Vorrichtung zum Schweißen von Bauteilen eines Feldgerätes |
| WO2005003557A1 (en) | 2003-06-25 | 2005-01-13 | Design Net Engineering, Llc | Laser propulsion thruster |
| ATE490787T1 (de) | 2003-07-15 | 2010-12-15 | Chugai Pharmaceutical Co Ltd | Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion |
| WO2005035574A1 (ja) | 2003-10-09 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | IgM高濃度安定化溶液 |
| US7803914B2 (en) | 2003-10-09 | 2010-09-28 | Chugai Seiyaku Kabushiki Kaisha | Methods for stabilizing protein solutions |
-
2004
- 2004-07-15 AT AT04747833T patent/ATE490787T1/de not_active IP Right Cessation
- 2004-07-15 CA CA2532966A patent/CA2532966C/en not_active Expired - Lifetime
- 2004-07-15 WO PCT/JP2004/010444 patent/WO2005005636A1/ja not_active Ceased
- 2004-07-15 US US10/564,665 patent/US7709615B2/en not_active Expired - Lifetime
- 2004-07-15 EP EP04747833A patent/EP1652925B1/de not_active Expired - Lifetime
- 2004-07-15 DE DE602004030451T patent/DE602004030451D1/de not_active Expired - Lifetime
- 2004-07-15 AU AU2004256354A patent/AU2004256354B2/en not_active Expired
- 2004-07-15 TW TW093121127A patent/TW200510532A/zh not_active IP Right Cessation
- 2004-07-15 JP JP2005511621A patent/JP5452835B2/ja not_active Expired - Lifetime
- 2004-07-15 EP EP10150954A patent/EP2204190A1/de not_active Withdrawn
-
2010
- 2010-03-18 US US12/727,162 patent/US8257703B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070154469A1 (en) | 2007-07-05 |
| JPWO2005005636A1 (ja) | 2006-08-24 |
| TW200510532A (en) | 2005-03-16 |
| WO2005005636A1 (ja) | 2005-01-20 |
| AU2004256354B2 (en) | 2011-07-07 |
| CA2532966C (en) | 2012-12-04 |
| EP1652925A4 (de) | 2007-07-04 |
| US8257703B2 (en) | 2012-09-04 |
| CA2532966A1 (en) | 2005-01-20 |
| EP1652925A1 (de) | 2006-05-03 |
| US20100172899A1 (en) | 2010-07-08 |
| EP1652925B1 (de) | 2010-12-08 |
| JP5452835B2 (ja) | 2014-03-26 |
| TWI342336B (de) | 2011-05-21 |
| AU2004256354A1 (en) | 2005-01-20 |
| DE602004030451D1 (de) | 2011-01-20 |
| US7709615B2 (en) | 2010-05-04 |
| EP2204190A1 (de) | 2010-07-07 |
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