ATE490787T1 - Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion - Google Patents
Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktionInfo
- Publication number
- ATE490787T1 ATE490787T1 AT04747833T AT04747833T ATE490787T1 AT E490787 T1 ATE490787 T1 AT E490787T1 AT 04747833 T AT04747833 T AT 04747833T AT 04747833 T AT04747833 T AT 04747833T AT E490787 T1 ATE490787 T1 AT E490787T1
- Authority
- AT
- Austria
- Prior art keywords
- igm
- production
- quantifying
- transformed cells
- chain
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 abstract 2
- 102100029571 Immunoglobulin J chain Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000012761 co-transfection Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48733303P | 2003-07-15 | 2003-07-15 | |
| PCT/JP2004/010444 WO2005005636A1 (ja) | 2003-07-15 | 2004-07-15 | 形質転換細胞によるIgMの産生とその定量方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490787T1 true ATE490787T1 (de) | 2010-12-15 |
Family
ID=34062150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04747833T ATE490787T1 (de) | 2003-07-15 | 2004-07-15 | Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7709615B2 (de) |
| EP (2) | EP2204190A1 (de) |
| JP (1) | JP5452835B2 (de) |
| AT (1) | ATE490787T1 (de) |
| AU (1) | AU2004256354B2 (de) |
| CA (1) | CA2532966C (de) |
| DE (1) | DE602004030451D1 (de) |
| TW (1) | TW200510532A (de) |
| WO (1) | WO2005005636A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004256354B2 (en) * | 2003-07-15 | 2011-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
| ATE518888T1 (de) * | 2003-10-09 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | Stabilisierte lösung mit hoher igm-konzentration |
| JP4671864B2 (ja) * | 2003-10-09 | 2011-04-20 | 中外製薬株式会社 | タンパク質溶液の安定化方法 |
| JP4818936B2 (ja) * | 2005-01-05 | 2011-11-16 | 中外製薬株式会社 | 細胞の培養方法およびその利用 |
| WO2007002676A2 (en) * | 2005-06-27 | 2007-01-04 | Invitrogen Corporation | Liquid protein markers for native gel electrophoresis |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| US9084777B2 (en) | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
| WO2007106617A2 (en) * | 2006-01-30 | 2007-09-20 | Talecris Biotherapeutics, Inc. | Method of treatment and prophylaxis of diseases related to amyloid deposition using igm |
| PT2047863E (pt) | 2006-06-08 | 2013-10-21 | Chugai Pharmaceutical Co Ltd | Prevenção ou tratamento para doença inflamatória |
| HU0700534D0 (en) | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
| CN101802192A (zh) | 2007-10-15 | 2010-08-11 | 中外制药株式会社 | 抗体的制备方法 |
| BRPI0821145B8 (pt) | 2007-12-05 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | uso de um anticorpo anti-nr10 como agente preventivo ou terapêutico para prurido |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| TWI466684B (zh) * | 2008-06-30 | 2015-01-01 | Morphotek Inc | 抗gd2抗體及其相關方法及用途 |
| EP2363148B1 (de) * | 2008-10-31 | 2014-11-26 | Japan Science and Technology Agency | Verfahren zur selektiven steuerung der funktion von t-helferzellen |
| TWI505838B (zh) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
| EP2735315B1 (de) | 2011-07-19 | 2019-10-02 | Chugai Seiyaku Kabushiki Kaisha | Proteinhaltige stabile zubereitung mit argininamid oder valinamid |
| JP6363017B2 (ja) | 2011-09-01 | 2018-07-25 | 中外製薬株式会社 | 限外ろ過によって高度に濃縮された抗体を含む組成物を調製するための方法 |
| CA2870625C (en) * | 2012-04-17 | 2023-06-20 | Mayo Foundation For Medical Education And Research | Human antibodies and specific binding sequences thereof for use in stroke and ischemia or ischemic conditions |
| CA2888652C (en) * | 2012-11-30 | 2020-09-22 | Katinger Gmbh | Recombinant human igm-antibody effective against cancer cells |
| WO2014093786A1 (en) * | 2012-12-14 | 2014-06-19 | Abbvie, Inc. | Methods for increasing the efficiency of hybridoma generation |
| US10654933B2 (en) | 2013-12-27 | 2020-05-19 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying antibody having low isoelectric point |
| HUE042829T2 (hu) | 2014-04-03 | 2019-07-29 | Igm Biosciences Inc | Módosított J-lánc |
| WO2016027859A1 (ja) | 2014-08-20 | 2016-02-25 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
| CA2972990A1 (en) | 2015-01-20 | 2016-07-28 | Beatrice Tien-Yi WANG | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| PL3265575T3 (pl) * | 2015-03-04 | 2021-11-29 | Igm Biosciences, Inc. | Cząsteczki wiążące CD20 i ich zastosowania |
| CA2980751A1 (en) * | 2015-03-25 | 2016-09-29 | Stephen F. Carroll | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CN108463472A (zh) | 2015-09-30 | 2018-08-28 | Igm生物科学有限公司 | 具有修饰的j-链的结合分子 |
| AU2016329197B2 (en) | 2015-09-30 | 2021-01-21 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| US10572893B2 (en) | 2016-06-16 | 2020-02-25 | International Business Machines Corporation | Discovering and interacting with proximate automobiles |
| CN112512480B (zh) | 2018-05-21 | 2024-10-01 | 中外制药株式会社 | 被封入玻璃容器的冷冻干燥制剂 |
| CN112243423B (zh) | 2018-05-28 | 2022-11-04 | 中外制药株式会社 | 填充喷嘴 |
| AU2020322031A1 (en) * | 2019-07-31 | 2022-03-10 | The Wistar Institute Of Anatomy And Biology | Multivalent DNA antibody constructs and use thereof |
| CA3173414A1 (en) * | 2020-04-22 | 2021-10-28 | Bruce Keyt | Pd-1 agonist multimeric binding molecules |
| US20240301064A1 (en) * | 2021-02-23 | 2024-09-12 | Pandion Operations, Inc. | Pd-1 antibodies, polypeptides and uses thereof |
| WO2023064841A1 (en) * | 2021-10-13 | 2023-04-20 | The Wistar Institute Of Anatomy And Biology | Antibodies for use against sars-cov-2 |
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| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| EP0303088B1 (de) | 1987-08-10 | 1992-11-11 | Miles Inc. | Gereinigtes IgM |
| US5157113A (en) * | 1987-08-10 | 1992-10-20 | Miles Inc. | Removal of nucleic acids from monoclonal antibody preparations |
| GB8719963D0 (en) * | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
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| US6238891B1 (en) * | 1987-11-18 | 2001-05-29 | Cetus Oncology Corporation | Method of increasing product expression through solute stress |
| JP2501116B2 (ja) | 1988-03-05 | 1996-05-29 | 日本電信電話株式会社 | 巡回制御形回線交換方法 |
| DE3825429C2 (de) | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| GB9010944D0 (en) | 1990-05-16 | 1990-07-04 | Central Blood Lab Authority | Chemical compounds |
| US5419904A (en) * | 1990-11-05 | 1995-05-30 | The Regents Of The University Of California | Human B-lymphoblastoid cell line secreting anti-ganglioside antibody |
| JPH05192181A (ja) | 1990-12-18 | 1993-08-03 | Ishihara Sangyo Kaisha Ltd | ヒトモノクローナル抗体 |
| EP0492409A1 (de) * | 1990-12-18 | 1992-07-01 | Ishihara Sangyo Kaisha, Ltd. | Menschlicher monoklonaler Antikörper |
| JPH0565233A (ja) | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
| AU660981B2 (en) * | 1991-03-12 | 1995-07-13 | Astellas Us Llc | CD2-binding domain of lymphocyte function associated antigen 3 |
| US5795965A (en) | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| JPH04360696A (ja) * | 1991-06-06 | 1992-12-14 | Sumitomo Chem Co Ltd | 新規なヒトbリンパ細胞株を宿主として産生された組み換えヒト抗体 |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
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| JP3565572B2 (ja) | 1992-09-07 | 2004-09-15 | 協和醗酵工業株式会社 | ヒト化抗体 |
| JPH06178689A (ja) * | 1992-12-11 | 1994-06-28 | Mitsui Toatsu Chem Inc | I型緑膿菌を抗原とするヒト抗体をコードする遺伝子 |
| JPH06189781A (ja) | 1992-12-25 | 1994-07-12 | Mitsui Toatsu Chem Inc | 培養液中の生理活性タンパク質の安定化方法 |
| JPH09127112A (ja) | 1995-10-30 | 1997-05-16 | Dainabotsuto Kk | 修飾IgM免疫学的測定試薬 |
| JPH09127114A (ja) | 1995-11-01 | 1997-05-16 | Dainabotsuto Kk | 免疫学的測定用安定化IgM試薬 |
| DE69730038T2 (de) * | 1996-08-16 | 2004-11-25 | The President And Fellows Of Harvard College, Cambridge | Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen |
| EP0835880A1 (de) | 1996-10-14 | 1998-04-15 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation |
| JPH10324699A (ja) * | 1997-03-21 | 1998-12-08 | Sankyo Co Ltd | 抗ヒトFasヒト化抗体 |
| MY131805A (en) | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| WO1999036105A2 (en) | 1998-01-16 | 1999-07-22 | Mca Development B.V. | USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE |
| WO1999037329A1 (en) | 1998-01-22 | 1999-07-29 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
| CA2321262A1 (en) | 1998-02-19 | 1999-08-26 | President And Fellows Of Harvard College | Monovalent, multivalent, and multimeric mhc binding domain fusion proteins and conjugates, and uses therefor |
| JP2000154149A (ja) * | 1998-09-18 | 2000-06-06 | Sankyo Co Ltd | 抗ヒトFasヒト化抗体含有抗リウマチ剤 |
| DK1121382T3 (da) * | 1998-10-16 | 2006-11-13 | Biogen Idec Inc | Interferon-beta-fusionsproteiner og deres anvendelser |
| WO2000061739A1 (fr) | 1999-04-09 | 2000-10-19 | Kyowa Hakko Kogyo Co., Ltd. | Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle |
| WO2000066160A1 (fr) | 1999-04-28 | 2000-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Composition medicamenteuse parenterale a fragment d'anticorps monoclonal humanise et procede de stabilisation |
| AU7449200A (en) | 1999-09-30 | 2001-04-30 | Kyowa Hakko Kogyo Co. Ltd. | Derivatives of antibody against ganglioside gm2 |
| AU1052701A (en) | 1999-11-05 | 2001-06-06 | Kyowa Hakko Kogyo Co. Ltd. | Transgenic non-human mammals for monitoring change in calcium ion concentration in cells |
| PT2857516T (pt) * | 2000-04-11 | 2017-08-28 | Genentech Inc | Anticorpos multivalentes e utilizações dos mesmos |
| WO2002003472A2 (en) | 2000-06-29 | 2002-01-10 | California Institute Of Technology | Aerosol silicon nanoparticles for use in semiconductor device fabrication |
| WO2002010371A1 (fr) * | 2000-08-01 | 2002-02-07 | Kyowa Hakko Kogyo Co., Ltd. | Peptide acitf sur le plan physiologique et utilisation de celui-ci |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| JP2003128576A (ja) * | 2001-10-25 | 2003-05-08 | Taisho Pharmaceut Co Ltd | エンドトキシン誘発性疾患治療薬 |
| AU2002356749A1 (en) * | 2001-11-28 | 2003-06-10 | Hermann Katinger | Process for the production of polypeptides in mammalian cell cultures |
| DE10328295B4 (de) | 2003-06-23 | 2007-11-22 | Endress + Hauser Gmbh + Co. Kg | Verfahren und entsprechende Vorrichtung zum Schweißen von Bauteilen eines Feldgerätes |
| US20070056262A1 (en) | 2003-06-25 | 2007-03-15 | Rachel Leach | Laser propulsion thruster |
| AU2004256354B2 (en) | 2003-07-15 | 2011-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
| ATE518888T1 (de) * | 2003-10-09 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | Stabilisierte lösung mit hoher igm-konzentration |
| JP4671864B2 (ja) | 2003-10-09 | 2011-04-20 | 中外製薬株式会社 | タンパク質溶液の安定化方法 |
-
2004
- 2004-07-15 AU AU2004256354A patent/AU2004256354B2/en not_active Expired
- 2004-07-15 DE DE602004030451T patent/DE602004030451D1/de not_active Expired - Lifetime
- 2004-07-15 AT AT04747833T patent/ATE490787T1/de not_active IP Right Cessation
- 2004-07-15 CA CA2532966A patent/CA2532966C/en not_active Expired - Lifetime
- 2004-07-15 TW TW093121127A patent/TW200510532A/zh not_active IP Right Cessation
- 2004-07-15 EP EP10150954A patent/EP2204190A1/de not_active Withdrawn
- 2004-07-15 JP JP2005511621A patent/JP5452835B2/ja not_active Expired - Lifetime
- 2004-07-15 WO PCT/JP2004/010444 patent/WO2005005636A1/ja not_active Ceased
- 2004-07-15 US US10/564,665 patent/US7709615B2/en active Active
- 2004-07-15 EP EP04747833A patent/EP1652925B1/de not_active Expired - Lifetime
-
2010
- 2010-03-18 US US12/727,162 patent/US8257703B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5452835B2 (ja) | 2014-03-26 |
| CA2532966A1 (en) | 2005-01-20 |
| US20070154469A1 (en) | 2007-07-05 |
| EP1652925A4 (de) | 2007-07-04 |
| CA2532966C (en) | 2012-12-04 |
| TWI342336B (de) | 2011-05-21 |
| TW200510532A (en) | 2005-03-16 |
| EP1652925A1 (de) | 2006-05-03 |
| US8257703B2 (en) | 2012-09-04 |
| US7709615B2 (en) | 2010-05-04 |
| WO2005005636A1 (ja) | 2005-01-20 |
| AU2004256354A1 (en) | 2005-01-20 |
| AU2004256354B2 (en) | 2011-07-07 |
| EP1652925B1 (de) | 2010-12-08 |
| US20100172899A1 (en) | 2010-07-08 |
| EP2204190A1 (de) | 2010-07-07 |
| DE602004030451D1 (de) | 2011-01-20 |
| JPWO2005005636A1 (ja) | 2006-08-24 |
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