CN1856469B - 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 - Google Patents
用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 Download PDFInfo
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- CN1856469B CN1856469B CN2004800210911A CN200480021091A CN1856469B CN 1856469 B CN1856469 B CN 1856469B CN 2004800210911 A CN2004800210911 A CN 2004800210911A CN 200480021091 A CN200480021091 A CN 200480021091A CN 1856469 B CN1856469 B CN 1856469B
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48910203P | 2003-07-23 | 2003-07-23 | |
US60/489,102 | 2003-07-23 | ||
US54032604P | 2004-02-02 | 2004-02-02 | |
US60/540,326 | 2004-02-02 | ||
PCT/US2004/023500 WO2005009961A2 (en) | 2003-07-23 | 2004-07-22 | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210293490.XA Division CN102816113B (zh) | 2003-07-23 | 2004-07-22 | 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1856469A CN1856469A (zh) | 2006-11-01 |
CN1856469B true CN1856469B (zh) | 2013-03-06 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN201210293490.XA Expired - Lifetime CN102816113B (zh) | 2003-07-23 | 2004-07-22 | 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 |
CN2004800210911A Expired - Lifetime CN1856469B (zh) | 2003-07-23 | 2004-07-22 | 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 |
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Country Status (36)
Families Citing this family (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2298311B1 (en) * | 1999-01-13 | 2012-05-09 | Bayer HealthCare LLC | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
US20080108672A1 (en) * | 2002-01-11 | 2008-05-08 | Bernd Riedl | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors |
PT1478358E (pt) | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
SI1580188T1 (sl) | 2002-02-11 | 2012-02-29 | Bayer Healthcare Llc | Aril sečnine kot kinazni inhibitorji |
NZ562410A (en) * | 2003-02-21 | 2009-02-28 | Resmed Ltd | Nasal pillow mask assembly |
UY28213A1 (es) * | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
ATE366108T1 (de) * | 2003-05-20 | 2007-07-15 | Bayer Pharmaceuticals Corp | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
DK1663978T3 (da) | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
CA2546673A1 (en) * | 2003-11-28 | 2005-06-09 | Novartis Ag | Diaryl urea derivatives in the treatment of protein kinase dependent diseases |
JP2007535565A (ja) | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | 癌の治療に有用な置換ピラゾリル尿素誘導体 |
AU2011244932B9 (en) * | 2004-08-27 | 2014-06-12 | Bayer Pharmaceuticals Corporation | New pharmaceutical compositions comprising 4-(4-(3-(4-chloro-3-trifluoromethyl-phenyl)-ureido)-3-fluoro-phenoxy)-pyridine-2-carboxylic acid for the treatment of hyper-proliferative disorders |
MY191349A (en) * | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
KR101381454B1 (ko) * | 2004-09-29 | 2014-04-04 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 열역학적으로 안정한 형태의 bay 43-9006 토실레이트 |
CN113975393A (zh) | 2005-02-03 | 2022-01-28 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
ATE482693T1 (de) | 2005-03-07 | 2010-10-15 | Bayer Schering Pharma Ag | Pharmazeutische zusammensetzung mit einem omega- carboxyaryl-substituierten diphenylharnstoff zur behandlung von krebs |
US20060216288A1 (en) * | 2005-03-22 | 2006-09-28 | Amgen Inc | Combinations for the treatment of cancer |
EP1886138A4 (en) * | 2005-05-11 | 2009-04-15 | Genetic Technologies Ltd | METHODS FOR ENRICHING FETAL CELLS |
US20090306020A1 (en) * | 2005-05-27 | 2009-12-10 | Bayer Healthcare Ag | Combination therapy comprising diaryl ureas for treating diseases |
BRPI0610048A2 (pt) * | 2005-05-27 | 2010-05-25 | Bayer Healthcare Ag | terapia de combinação que compreende um composto de diaril uréia e uma pi3, akt quinase ou inibidores de mtor (rapamicinas) para o tratamento de cáncer |
AR057854A1 (es) | 2005-11-04 | 2007-12-19 | Wyeth Corp | Combinaciones antineoplasicas con inhibidor de mtor, herceptina y/o hki-272 (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi) anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida |
KR20080067000A (ko) * | 2005-11-10 | 2008-07-17 | 바이엘 헬스케어 아게 | 폐 고혈압을 치료하기 위한 디아릴 우레아 |
EP1948144A2 (en) * | 2005-11-10 | 2008-07-30 | Bayer HealthCare AG | Diaryl urea for treating diabetic neuropathy |
RU2431484C2 (ru) * | 2005-11-10 | 2011-10-20 | Байер Шеринг Фарма Акциенгезельшафт | Диарилмочевина для лечения легочной гипертензии |
JP2009519267A (ja) * | 2005-12-15 | 2009-05-14 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 炎症性の皮膚、眼および/または耳疾患を処置するためのジアリールウレア |
WO2007068380A1 (en) * | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl urea for treating virus infections |
CA2633411A1 (en) * | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl ureas for treating inflammatory skin, eye and/or ear diseases |
AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
JP2009528365A (ja) * | 2006-02-28 | 2009-08-06 | アムゲン インコーポレイティッド | ホスホジエステラーゼ10阻害剤としてのシンノリン及びキナゾリン誘導体 |
CN101058561B (zh) * | 2006-04-19 | 2011-01-26 | 苏州爱斯鹏药物研发有限责任公司 | 用于抑制蛋白激酶的二苯脲衍生物及其组合物和用途 |
CA2649877A1 (en) | 2006-04-24 | 2007-12-21 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
MX2008014953A (es) * | 2006-05-26 | 2009-03-05 | Bayer Healthcare Llc | Combinaciones de medicamentos con diarilureas sustituidas para el tratamiento de cancer. |
WO2007146730A2 (en) | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
CL2007001829A1 (es) * | 2006-06-23 | 2008-01-25 | Smithkline Beecham Corp | P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc. |
WO2008030448A1 (en) * | 2006-09-07 | 2008-03-13 | Millennium Pharmaceuticals, Inc. | Phenethylamide derivatives with kinase inhibitory activity |
WO2008044688A1 (fr) * | 2006-10-11 | 2008-04-17 | Daiichi Sankyo Company, Limited | Dérivé de l'urée |
AR062927A1 (es) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
EP2081902A1 (en) * | 2006-11-09 | 2009-07-29 | Bayer Schering Pharma Aktiengesellschaft | Polymorph iii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide |
EP2089363A1 (en) * | 2006-11-14 | 2009-08-19 | Bayer Schering Pharma Aktiengesellschaft | Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]n-methylpyridine-2-carboxamide |
EP2102230A2 (en) | 2006-12-29 | 2009-09-23 | Gloucester Pharmaceuticals, Inc. | Purifiction of romidepsin |
BRPI0806341A2 (pt) * | 2007-01-10 | 2011-09-06 | Novartis Ag | formulações de inibidores de desacetilase |
JP2010516692A (ja) * | 2007-01-19 | 2010-05-20 | バイエル・ヘルスケア・エルエルシー | 化学療法剤に対し抵抗性を有する癌の処置 |
CA2675980C (en) * | 2007-01-19 | 2016-06-21 | Bayer Healthcare Llc | Use of dast for treatment of cancers with acquired resistance to kit inhibitors |
US20080234332A1 (en) * | 2007-03-20 | 2008-09-25 | Xiong Cai | Raf kinase inhibitors containing a zinc binding moiety |
US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
WO2008120004A1 (en) * | 2007-04-02 | 2008-10-09 | Astrazeneca Ab | Combination of a mek- inhibitor and a b-raf inhibitor for the treatment of cancer |
KR101721161B1 (ko) | 2007-07-25 | 2017-03-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 암 치료에서 이용하기 위한 멀티키나아제 억제제 |
WO2009021150A2 (en) * | 2007-08-08 | 2009-02-12 | California Pacific Medical Center | Platelet derived growth factor receptor supports cytomegalovirus infectivity |
CL2008002786A1 (es) * | 2007-09-20 | 2009-05-15 | Novartis Ag | Torta farmceuticamente aceptable, formada por liofilizacion, que comprende: n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il]-etil]-amino]-metil]-fenil]-2e-2-propenamida o una sal, un regulador de ph seleciondo de lactato o acidop lactico, fodfato o acido fosforico o una combinacion y un agente de volumen; proceso de elaboracion. |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
ATE545023T1 (de) * | 2007-10-29 | 2012-02-15 | Eisai R&D Man Co Ltd | Verfahren zur vorhersage der fähigkeit einer zearalenon-analogverbindung für die krebsbehandlung |
CN101220024A (zh) * | 2007-12-11 | 2008-07-16 | 杜晓敏 | 一组抑制激酶的抗癌化合物 |
WO2009132397A1 (en) * | 2008-05-01 | 2009-11-05 | University Of South Australia | Methods and agents for modulating the level and/or activity of hif-2 alpha protein |
ES2692769T3 (es) | 2008-06-17 | 2018-12-05 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
JP2011525503A (ja) * | 2008-06-25 | 2011-09-22 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 心不全を処置するためのジアリールウレア |
CN102076338A (zh) * | 2008-06-25 | 2011-05-25 | 拜耳先灵制药股份公司 | 治疗心力衰竭的二芳基脲类 |
US9410956B1 (en) * | 2008-08-01 | 2016-08-09 | University Of South Florida | Micro-RNA profiling in ovarian cancer |
CN115990181A (zh) | 2008-08-04 | 2023-04-21 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
EP2156834A1 (en) * | 2008-08-08 | 2010-02-24 | S.I.F.I - Società Industria Farmaceutica Italiana - S.P.A. | Ophthalmic pharmaceutical compositions comprising Sorafenib for the treatment of neoangiogenic pathologies of the eye |
WO2010019701A2 (en) * | 2008-08-14 | 2010-02-18 | Concert Pharmaceuticals, Inc. | Diaryl urea derivatives |
CN103254126A (zh) * | 2008-09-19 | 2013-08-21 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
CN102516154B (zh) * | 2008-09-19 | 2015-03-18 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
WO2010108503A1 (en) | 2009-03-24 | 2010-09-30 | Life & Brain Gmbh | Promotion of neuronal integration in neural stem cell grafts |
KR20220143154A (ko) | 2009-04-06 | 2022-10-24 | 와이어쓰 엘엘씨 | 네라티닙을 이용한 유방암의 치료법 |
US8410082B2 (en) | 2009-05-22 | 2013-04-02 | Concert Pharmaceuticals, Inc. | Fluorinated diaryl urea derivatives |
CN102190616B (zh) | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
AR081060A1 (es) * | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
AU2015201426B2 (en) * | 2010-04-15 | 2016-07-07 | Bayer Healthcare Llc | Process for the preparation of 4- {4-[({[4 -chloro-3 -(trifluoromethyl)-phenyl]amino} carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate |
CN103079567A (zh) * | 2010-04-17 | 2013-05-01 | 拜尔健康护理有限责任公司 | 用于疾病和病症的治疗和预防的氟取代的ω-羧基芳基二苯脲的合成代谢产物 |
WO2011146725A1 (en) | 2010-05-19 | 2011-11-24 | Bayer Healthcare Llc | Biomarkers for a multikinase inhibitor |
KR20130092557A (ko) | 2010-07-12 | 2013-08-20 | 셀진 코포레이션 | 로미뎁신 고체 형태 및 그의 용도 |
US20130183268A1 (en) * | 2010-07-19 | 2013-07-18 | Bayer Healthcare Llc | Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
US20140057908A1 (en) | 2010-09-27 | 2014-02-27 | Exelixis, Inc. | Method of Treating Cancer |
WO2012041987A1 (en) * | 2010-10-01 | 2012-04-05 | Bayer Pharma Aktiengesellschaft | Substituted n-(2-arylamino)aryl sulfonamide-containing combinations |
WO2012118978A1 (en) * | 2011-03-03 | 2012-09-07 | The Regents Of The University Of Colorado, A Body Corporate | Methods for treating oncovirus positive cancers |
ES2699532T3 (es) | 2011-03-23 | 2019-02-11 | Univ California | Métodos y composiciones para mejorar la terapia antiangiogénica con anti-integrinas |
JO3438B1 (ar) * | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
WO2012162025A1 (en) * | 2011-05-20 | 2012-11-29 | President And Fellows Of Harvard College | Methods of selecting cancer patients for treatment with n,n'-diarylurea compounds and n,n'-diarylthiourea compounds |
MX2013015287A (es) * | 2011-06-28 | 2014-03-31 | Bayer Healthcare Llc | Composicion farmaceutica oftalmologica topica que contiene regorafenib. |
EP2543372A1 (en) * | 2011-07-08 | 2013-01-09 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for the treatment of liver cancer |
EP3111937B1 (en) | 2011-07-08 | 2020-06-17 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for treatment of liver cancer |
KR101374530B1 (ko) * | 2011-07-14 | 2014-03-14 | 연세대학교 원주산학협력단 | 디에틸스틸베스트롤을 함유하는 심혈관 질환의 예방 또는 치료용 조성물 |
CN104023715B (zh) * | 2011-12-02 | 2016-10-26 | Ea制药株式会社 | 激酶抑制剂的副作用降低剂 |
CN103169720B (zh) * | 2011-12-21 | 2016-12-07 | 张雅珍 | 蒽环类抗生素及其可药用盐在治疗视网膜静脉阻塞中的用途 |
BRPI1107182B1 (pt) * | 2011-12-29 | 2022-03-08 | Fundação De Amparo À Pesquisa Do Estado De Minas Gerais - Fapemig | Composições farmacêuticas contendo ang-(1-7) ou outro agonista do receptor mas em combinação com inibidores de pi3k/akt para tratamento terapêutico anticâncer |
JP2015527874A (ja) | 2012-05-31 | 2015-09-24 | バイエル ファーマ アクチエンゲゼルシャフト | 肝細胞癌(hcc)患者の治療の有効な応答を決定するためのバイオマーカー |
KR101386697B1 (ko) * | 2012-06-18 | 2014-04-18 | 아주대학교산학협력단 | 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물 |
CN104379128A (zh) * | 2012-06-25 | 2015-02-25 | 拜尔健康护理有限责任公司 | 含有西地尼布的局部眼科药物组合物 |
UY35006A (es) * | 2012-09-06 | 2014-03-31 | Bayer Healthcare Llc | Composición farmacéutica recubierta que contiene regorafenib |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
PT2900269T (pt) * | 2012-09-25 | 2018-10-22 | Bayer Pharma AG | Combinação de regorafenib e ácido acetilsalicílico para o tratamento de cancro colorretal |
AU2013331380B2 (en) | 2012-10-15 | 2018-03-22 | Epizyme, Inc. | Substituted benzene compounds |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
UY35183A (es) | 2012-12-21 | 2014-07-31 | Bayer Healthcare Llc | Composición farmacéutica oftalmológica tópica que contiene regorafenib |
CN104250227A (zh) * | 2013-06-29 | 2014-12-31 | 广东东阳光药业有限公司 | 瑞戈非尼新晶型及其制备方法 |
WO2015006753A2 (en) * | 2013-07-12 | 2015-01-15 | The Regents Of The University Of California | Therapies for diseases caused by arthropod-borne parasites |
WO2015011659A1 (en) * | 2013-07-24 | 2015-01-29 | Dr. Reddys Laboratories Limited | Crystalline polymorphic forms of regorafenib and processes for the preparation of polymorph i of regorafenib |
WO2015035531A1 (zh) * | 2013-09-12 | 2015-03-19 | 杭州普晒医药科技有限公司 | 瑞格非尼盐晶型及其制备方法和用途 |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
CN103923000A (zh) * | 2014-01-29 | 2014-07-16 | 苏州晶云药物科技有限公司 | 几种新晶型及其制备方法 |
CN104829523B (zh) * | 2014-04-30 | 2017-10-31 | 药源药物化学(上海)有限公司 | 瑞戈非尼盐及其晶型、制备方法 |
WO2016005874A1 (en) * | 2014-07-09 | 2016-01-14 | Shilpa Medicare Limited | Process for the preparation of regorafenib and its crystalline forms |
WO2016038590A1 (en) | 2014-09-12 | 2016-03-17 | Mylan Laboratories Ltd | Process for the preparation of crystalline form i of regorafenib |
WO2016051422A2 (en) * | 2014-09-29 | 2016-04-07 | Msn Laboratories Private Limited | Process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide and its polymorphs thereof |
CN105566215B (zh) * | 2014-10-17 | 2018-02-16 | 沈阳药科大学 | 一种瑞戈非尼的制备方法 |
CN105777625B (zh) * | 2014-12-24 | 2020-05-22 | 浙江海正药业股份有限公司 | 一种制备4-(4-氨基-3-氟苯氧基)-n-甲基吡啶-2-甲酰胺的方法 |
CN104586808B (zh) * | 2014-12-27 | 2017-08-18 | 北京元延医药科技股份有限公司 | 抗肿瘤药物组合物 |
CN104910067A (zh) * | 2015-03-05 | 2015-09-16 | 南京工业大学 | 一锅法合成瑞戈非尼的方法 |
CN105218440A (zh) * | 2015-09-07 | 2016-01-06 | 河南中医学院 | 一种高纯瑞戈非尼的制备方法 |
CN105330600B (zh) * | 2015-11-30 | 2018-05-22 | 山东罗欣药业集团股份有限公司 | 一种瑞戈菲尼的制备方法 |
SG11201806116SA (en) * | 2016-01-18 | 2018-08-30 | Natco Pharma Ltd | An improved process for the preparation of regorafenib |
WO2017134588A1 (en) | 2016-02-04 | 2017-08-10 | Shilpa Medicare Limited | Process for the preparation of ibrutinib |
RS66090B1 (sr) * | 2016-03-02 | 2024-11-29 | Medivir Ab | Kombinovana terapija sa sorafenibom ili regorafenibom i fosforamidatnim prolekom troksacitabina |
CN110072526A (zh) * | 2016-08-17 | 2019-07-30 | 西奈山伊坎医学院 | 治疗癌症的激酶抑制剂化合物、组合物和方法 |
CN117510405A (zh) | 2017-04-18 | 2024-02-06 | 礼来公司 | 苯基-2-羟基-乙酰氨基-2-甲基-苯基化合物 |
CN117899212A (zh) | 2017-06-02 | 2024-04-19 | 拜耳医药保健有限责任公司 | 用于治疗癌症的瑞格菲尼和pd-1/pd-l1(2)抑制剂的组合产品 |
JP7348665B2 (ja) | 2018-02-06 | 2023-09-21 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | 選択的エストロゲン受容体分解剤としての置換ベンゾチオフェン類似体 |
EP4219489A3 (en) | 2018-05-30 | 2023-11-15 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
CN111053751A (zh) * | 2018-10-16 | 2020-04-24 | 正大天晴药业集团股份有限公司 | 瑞戈非尼的缓释片剂及其制备方法 |
CN109796401B (zh) * | 2019-04-04 | 2023-10-17 | 新乡双鹭药业有限公司 | 一种瑞戈非尼原料药的制备方法 |
GB201913123D0 (en) * | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
EP3861989A1 (en) | 2020-02-07 | 2021-08-11 | Bayer Aktiengesellschaft | Pharmaceutical composition containing regorafenib and a stabilizing agent |
WO2021160708A1 (en) | 2020-02-14 | 2021-08-19 | Bayer Aktiengesellschaft | Combination of regorafenib and msln-ttc for treating cancer |
CN112159351B (zh) * | 2020-09-21 | 2021-12-07 | 广州南鑫药业有限公司 | 一种多靶点抗肿瘤药物的制备方法 |
IT202000022636A1 (it) | 2020-09-25 | 2022-03-25 | Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter | “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma” |
CN112842998A (zh) * | 2021-01-19 | 2021-05-28 | 深圳市简一生物科技有限公司 | 一种瑞戈非尼分散剂及其制备方法 |
CN117233391A (zh) * | 2023-08-28 | 2023-12-15 | 南方医科大学南方医院 | 一种用于预测胃癌免疫治疗和/或化疗疗效的生物标志物及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
WO2003047523A2 (en) * | 2001-12-04 | 2003-06-12 | Onyx Pharmaceuticals, Inc. | Raf-mek-erk pathway inhibitors to treat cancer |
Family Cites Families (473)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US502504A (en) | 1893-08-01 | Hermann thoms | ||
DE487014C (de) | 1927-10-23 | 1929-12-09 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Harnstoffderivaten |
US1792156A (en) | 1928-01-17 | 1931-02-10 | Gen Aniline Works Inc | 5-halogen-2-amino-1-alkyloxy and 1-aralkyloxy-benzenes and intermediate products thereof and process of preparing them |
DE511468C (de) | 1928-01-18 | 1930-10-30 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von 5-Chlor-2-amino-1-methoxybenzol |
DE523437C (de) | 1928-12-25 | 1931-05-05 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von 5-Chlor- und 5-Brom-2-amino-1-alkyloxy- und 1-aralkyloxybenzolen |
US2093265A (en) | 1931-03-31 | 1937-09-14 | Ici Ltd | Process for the manufacture of diaryl ureas |
US2046375A (en) | 1931-06-04 | 1936-07-07 | Ici Ltd | p-halogen-omicron-alkoxy-aniline derivatives and process of preparing the same |
US2288422A (en) | 1938-11-11 | 1942-06-30 | Gen Aniline & Film Corp | Mixed ureas |
US2973386A (en) | 1943-01-05 | 1961-02-28 | Harry A Weldon | Purification of sym dichloro-bis (2, 4, 6-trichlorophenyl)urea |
US2502504A (en) * | 1946-10-18 | 1950-04-04 | John L Botner | Hogshead |
DE925476C (de) | 1950-04-29 | 1955-03-21 | Variapat Ag | Verfahren zur Herstellung von farblosen, wasserloeslichen, trifluormethyl- und sulfonsaeuregruppenhaltigen, aliphatischen oder aromatischen Carbonsaeure- bzw. Sulfonsaeurearyliden |
US2683082A (en) | 1950-12-09 | 1954-07-06 | Ethyl Corp | Nu-aryl-nu'-(p-hydroxyphenyl) ureas as antioxidants for petroleum hydrocarbon fuels |
US2722544A (en) | 1950-12-26 | 1955-11-01 | Variapat Ag | Trifluoromethyl halogenated diphenylcarbamide sulfonic acids and their preparation |
US2781330A (en) | 1953-02-09 | 1957-02-12 | Monsanto Chemicals | Rubber containing urea compound as an anti-exposure cracking agent |
BE527017A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1953-03-06 | |||
US2745874A (en) | 1953-06-18 | 1956-05-15 | Geigy Ag J R | Insecticidal derivatives of diphenyl urea |
NL193403A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1953-12-22 | 1924-02-17 | ||
GB771333A (en) | 1953-12-22 | 1957-03-27 | Geigy Ag J R | Improvements relating to halogen substituted diphenyl urea and thiourea compounds and their use |
GB828231A (en) | 1955-10-20 | 1960-02-17 | Geigy Ag J R | Improvements relating to insecticidal compounds and their use |
US2877268A (en) | 1956-12-24 | 1959-03-10 | Monsanto Chemicals | Substituted ureas |
US2960488A (en) | 1958-04-25 | 1960-11-15 | Eastman Kodak Co | Poly-alpha-olefins containing substituted ureas |
NL254871A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1959-08-14 | |||
NL277511A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1961-04-21 | |||
CH479557A (de) | 1961-09-11 | 1969-10-15 | Wander Ag Dr A | Verfahren zur Herstellung neuer mehrbasischer Verbindungen |
US3200035A (en) | 1962-06-01 | 1965-08-10 | Ciba Ltd | Treatment of synthetic products, especially synthetic fibers |
US3284433A (en) | 1963-07-17 | 1966-11-08 | Merck & Co Inc | 4-phenoxy-carbanilides |
FR1457172A (fr) | 1964-12-12 | 1966-10-28 | Ferrania Spa | Procédé pour la production d'images photographiques en couleurs et matériel photographique correspondant |
FR90420E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1965-06-09 | 1968-02-21 | ||
US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
US3424762A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | Certain 3-ureidopyrrolidines |
US3743498A (en) | 1967-10-31 | 1973-07-03 | Du Pont | Method of selectively controlling undesirable vegetation |
US3547940A (en) | 1967-10-31 | 1970-12-15 | Du Pont | Substituted ureido isoxazoles |
SE370866B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-03-21 | 1974-11-04 | Ciba Geigy Ag | |
DE1768244A1 (de) | 1968-04-19 | 1971-10-14 | Bayer Ag | N-(2,2,4,4-Tetrafluor-1,3-benz-dioxanyl)-harnstoffe und Verfahren zu ihrer Herstellung |
US3646059A (en) | 1969-05-05 | 1972-02-29 | Du Pont | Plant growth regulatory ureidopyrazoles |
US3754887A (en) | 1969-05-05 | 1973-08-28 | Du Pont | Ureidopyrazoles defoliants |
US3668222A (en) | 1969-05-14 | 1972-06-06 | Sandoz Ltd | 11-desacetoxy-wortmannin |
BE754782A (fr) | 1969-08-14 | 1971-02-12 | May & Baker Ltd | Derives du thiophene a action herbicide |
US3823161A (en) | 1970-05-07 | 1974-07-09 | Exxon Research Engineering Co | Aminothiophene derivatives |
US3860645A (en) | 1973-05-23 | 1975-01-14 | Givaudan Corp | Bacteriostatic substituted carbanilides |
US4116671A (en) | 1973-07-27 | 1978-09-26 | Shionogi & Co., Ltd. | 3-Isoxazolylcarbamate derivatives |
JPS5031039A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-07-27 | 1975-03-27 | ||
US4212981A (en) | 1973-07-27 | 1980-07-15 | Shionogi & Co., Ltd. | Process for preparing 3-isoxazolylurea derivatives |
US4062861A (en) | 1973-07-27 | 1977-12-13 | Shionogi & Co., Ltd. | 3-Isoxazolylurea derivatives |
US4001256A (en) | 1973-12-26 | 1977-01-04 | The Upjohn Company | Pyridylalkyl phenyl ureas and their n-oxides |
US3931201A (en) | 1974-01-22 | 1976-01-06 | The Dow Chemical Company | Substituted pyridinyloxy(thio)phenyl -acetamides, -ureas and urea derivatives |
US4009847A (en) | 1974-04-17 | 1977-03-01 | E. I. Du Pont De Nemours And Company | 1-Tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas as antihypertensive agents |
US3990879A (en) | 1974-12-26 | 1976-11-09 | Eli Lilly And Company | Method of controlling aquatic weeds |
US4111683A (en) | 1975-06-27 | 1978-09-05 | Chevron Research Company | N-alkyl or alkoxy-N'-substituted hydrocarbyl urea |
DE2637947C2 (de) | 1976-08-24 | 1985-09-19 | Bayer Ag, 5090 Leverkusen | Tetrafluor-1,3-benzodioxanyl-benzoylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Insektizide |
US4173637A (en) | 1976-10-29 | 1979-11-06 | Ishihara Sangyo Kaisha Ltd. | N-Benzoyl-N'-pyridyloxy phenyl urea and insecticidal compositions thereof |
JPS5840946B2 (ja) | 1976-10-29 | 1983-09-08 | 石原産業株式会社 | N−ベンゾイル−n′−ピリジルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する殺虫剤 |
US4071524A (en) | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
US4183854A (en) | 1976-11-10 | 1980-01-15 | John Wyeth & Brother Limited | Thiazole compound |
US4042372A (en) | 1976-11-19 | 1977-08-16 | Eli Lilly And Company | Substituted thiadiazolotriazinediones and method of preparation |
DE2817449A1 (de) | 1978-04-21 | 1979-10-31 | Bayer Ag | Mittel zur regulierung des pflanzenwachstums |
GB1590870A (en) | 1978-05-31 | 1981-06-10 | Shionogi & Co | N-(5-t-butyl-3-isoxazolyl) alkanamide derivatives having herbicidal activity |
JPS5562066A (en) | 1978-11-03 | 1980-05-10 | Toshihiko Okamoto | N-(2-substituted-4-pyridyl)-urea and thio urea, their preparation and plant growth regulator |
DE2848330A1 (de) | 1978-11-03 | 1980-05-14 | Schering Ag | Verfahren zur herstellung von 1,2, 3-thiadiazol-5-yl-harnstoffen |
FI800559A7 (fi) | 1979-03-14 | 1981-01-01 | F Hoffmann La Roche & Co | Virtsa-ainejohdannaiset. |
JPS55124763A (en) | 1979-03-19 | 1980-09-26 | Ishihara Sangyo Kaisha Ltd | 5-trifluoromethyl-2-pyridone derivative |
DE2928485A1 (de) | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
US4468380A (en) | 1979-12-26 | 1984-08-28 | Eli Lilly And Company | Anticoccidial combinations comprising polyether antibiotics and carbanilides |
US4410697A (en) | 1980-01-25 | 1983-10-18 | Reanal Finomvegyszergyar | Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives |
ATE9131T1 (de) | 1980-05-14 | 1984-09-15 | Ciba-Geigy Ag | Phenylbenzoylharnstoffe. |
EP0057797B1 (en) | 1981-02-03 | 1986-06-25 | Imperial Chemical Industries Plc | Process for the extraction of metal values and novel metal extractants |
US4526997A (en) | 1981-05-06 | 1985-07-02 | Doherty George O P O | Anticoccidial combinations comprising polyether antibiotics and carbanilides |
US4511571A (en) | 1981-10-20 | 1985-04-16 | Ciba Geigy Corporation | N-(2-Pyridyloxyphenyl)-N'-benzoyl ureas, pesticidal compositions containing same and pesticidal methods of use |
US4473579A (en) | 1982-01-26 | 1984-09-25 | American Cyanamid Company | Antiatherosclerotic tetrasubstituted ureas and thioureas |
US4623662A (en) | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
DE3211851A1 (de) | 1982-03-31 | 1983-10-06 | Basf Ag | Dihydrothiophen-carbonester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
JPS58203957A (ja) | 1982-05-25 | 1983-11-28 | Ube Ind Ltd | 尿素誘導体の製法 |
IL69621A0 (en) | 1982-09-02 | 1983-12-30 | Duphar Int Res | Pharmaceutical compositions having antitumor activity,comprising certain phenylurea derivatives |
CA1254212A (en) | 1982-11-12 | 1989-05-16 | Shiro Hirai | Amine derivatives, salts thereof, process for preparing the same and an anti-ulcer agent containing the same |
DE3305866A1 (de) | 1983-02-19 | 1984-08-23 | Basf Ag, 6700 Ludwigshafen | Thiophen-carbonester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
US4499097A (en) | 1983-03-10 | 1985-02-12 | American Cyanamid Company | 2-(Pyridyl)imidazolyl ketones |
GB8325496D0 (en) | 1983-09-23 | 1983-10-26 | Hider R C | Pharmaceutical compositions |
CH663353A5 (de) | 1984-03-28 | 1987-12-15 | Joaquin Amat Larraz | Mittel gegen krebs. |
US4540566A (en) | 1984-04-02 | 1985-09-10 | Forest Laboratories, Inc. | Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose |
JPS6193163A (ja) | 1984-10-12 | 1986-05-12 | Ishihara Sangyo Kaisha Ltd | N−ベンゾイル−n′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤 |
US4727077A (en) | 1985-02-20 | 1988-02-23 | Ishihara Sangyo Kaisha Ltd. | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them |
DE3529247A1 (de) | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
DE3540377A1 (de) | 1985-11-14 | 1987-05-21 | Bayer Ag | Thienooxazinone, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer |
DE3541631A1 (de) | 1985-11-26 | 1987-05-27 | Bayer Ag | Selektiv-fungizide verwendung von thienylharnstoff-derivaten |
AU594098B2 (en) | 1985-12-11 | 1990-03-01 | Ishihara Sangyo Kaisha Ltd. | N-benzoyl urea compounds, antitumorous compositions containing them, and process for their preparation |
EP0230400A3 (de) | 1986-01-21 | 1990-02-14 | Ciba-Geigy Ag | N-3-(5-Trifluormethyl-pyridyl-2-oxy)-phenyl-N'-benzoylharnstoffe zur Bekämpfung von Helminthen an Nutztieren |
JPS62185013A (ja) | 1986-02-08 | 1987-08-13 | Green Cross Corp:The | 易吸収性医薬組成物 |
DE3612830A1 (de) | 1986-04-16 | 1987-10-22 | Basf Ag | Thiadiazolylharnstoff enthaltendes mittel zur entblaetterung von pflanzen |
EP0255297B1 (en) | 1986-07-31 | 1993-04-21 | Beecham Group Plc | Azabicyclic compounds, process for their preparation, and their pharmaceutical use |
EP0262560A3 (en) | 1986-09-29 | 1989-07-05 | Ishihara Sangyo Kaisha, Ltd. | Benzoyl urea compound |
US4835180A (en) | 1986-10-02 | 1989-05-30 | Sterling Drug Inc. | N-(ω-cyanoalkyl)aminophenols and use as inhibitors of lipoxygenase activity |
NZ221964A (en) | 1986-10-03 | 1990-03-27 | Ishihara Sangyo Kaisha | Benzoylurea compounds and insecticidal compositions |
US4983605A (en) | 1986-10-23 | 1991-01-08 | Ishihara Sangyo Kaisha Ltd. | Pharmaceutical composition |
DE3636190A1 (de) | 1986-10-24 | 1988-04-28 | Bayer Ag | Verfahren zur herstellung von n,n-diaryl-harnstoffen |
JPH06100808B2 (ja) | 1987-05-28 | 1994-12-12 | 富士写真フイルム株式会社 | ハロゲン化銀カラ−写真感光材料の処理方法 |
ES2070861T3 (es) | 1987-10-16 | 1995-06-16 | Ciba Geigy Ag | Compuestos antiparasitarios. |
DE3810382A1 (de) | 1988-03-26 | 1989-10-12 | Bayer Ag | 5-amino-1-phenylpyrazole, verfahren sowie 5-halogen-1-phenylpyrazole als zwischenprodukte zu deren herstellung und ihre verwendung als herbizide |
AU636853B2 (en) | 1988-08-23 | 1993-05-13 | Nutrasweet Company, The | Substituted aryl ureas as high potency sweeteners |
JPH0278699A (ja) | 1988-09-12 | 1990-03-19 | Green Cross Corp:The | ベンゾイルウレア系化合物・アルブミン複合体 |
FR2639636B1 (fr) | 1988-11-30 | 1994-03-04 | Novapharme | Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant |
FR2662692B1 (fr) | 1990-05-30 | 1995-04-28 | Novapharme | Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique. |
JPH02237922A (ja) | 1989-01-24 | 1990-09-20 | Green Cross Corp:The | 抗ウィルス剤 |
JPH02196719A (ja) | 1989-01-24 | 1990-08-03 | Green Cross Corp:The | 粉末状医薬組成物 |
EP0379915A1 (de) | 1989-01-26 | 1990-08-01 | Bayer Ag | Substituierte Phenoxybenzonitril-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwuchsregulatoren |
JP3002204B2 (ja) | 1989-03-13 | 2000-01-24 | 株式会社東芝 | 時系列信号認識装置 |
US4973675A (en) | 1989-04-13 | 1990-11-27 | University Of Tennessee Research Center | Hybrid nitrosoureidoanthracyclines having antitumor activity |
JPH0395153A (ja) | 1989-06-15 | 1991-04-19 | Mitsubishi Kasei Corp | ジフェニル尿素誘導体 |
US5665543A (en) | 1989-07-18 | 1997-09-09 | Oncogene Science, Inc. | Method of discovering chemicals capable of functioning as gene expression modulators |
IL95860A0 (en) | 1989-10-13 | 1991-07-18 | Ciba Geigy Ag | Thienylthioureas,-isothioureas and-carbodiimides |
EP0425443A1 (de) | 1989-10-27 | 1991-05-02 | Ciba-Geigy Ag | Injizierbares parasitizides Mittel |
DK40890D0 (da) | 1990-02-16 | 1990-02-16 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
EP0487745A4 (en) | 1990-06-19 | 1993-01-20 | Meiji Seika Kabushiki Kaisha | Pyridine derivative with angiotensin ii antagonism |
GB9017892D0 (en) | 1990-08-15 | 1990-09-26 | May & Baker Ltd | New compositions of matter |
AU646722B2 (en) | 1991-01-21 | 1994-03-03 | Shionogi Seiyaku Kabushiki Kaisha | 3-benzylidene-1-carbamoyl-2-pyrrolidone analog |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5270458A (en) | 1991-04-02 | 1993-12-14 | The Trustees Of Princeton University | Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 |
US5185438A (en) | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
NO921449L (no) | 1991-04-17 | 1992-10-19 | American Home Prod | Karbamater av rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
US5162360A (en) | 1991-06-24 | 1992-11-10 | Warner-Lambert Company | 2-heteroatom containing urea and thiourea ACAT inhibitors |
US5185358A (en) | 1991-06-24 | 1993-02-09 | Warner-Lambert Co. | 3-heteroatom containing urea and thiourea ACAT inhibitors |
AU2552492A (en) | 1991-08-23 | 1993-03-16 | United States of America as represented by The Secretary Department of Health and Human Services, The | Raf protein kinase therapeutics |
US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
US5254582A (en) | 1992-02-05 | 1993-10-19 | Eli Lilly And Company | Antitumor compositions and methods |
US5508288A (en) | 1992-03-12 | 1996-04-16 | Smithkline Beecham, P.L.C. | Indole derivatives as 5HT1C antagonists |
SK142694A3 (en) | 1992-05-28 | 1995-06-07 | Pfizer | N-aryl and n-heteroarylurea derivatives as inhibitors of acylcoenzyme a:cholesterol-acyltransferase, pharmaceutical preparations contains these compounds and use |
US5312820A (en) | 1992-07-17 | 1994-05-17 | Merck & Co., Inc. | Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines |
US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
JP2717481B2 (ja) | 1992-08-25 | 1998-02-18 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料 |
CN2146707Y (zh) | 1992-09-08 | 1993-11-17 | 华东冶金学院 | 高炉软水冷却系统检漏装置 |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
WO1994014801A1 (en) | 1992-12-29 | 1994-07-07 | Smithkline Beecham Plc | Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists |
US5512473A (en) | 1993-01-29 | 1996-04-30 | Brent; Roger | Max-interacting proteins and related molecules and methods |
GB9302275D0 (en) | 1993-02-05 | 1993-03-24 | Smithkline Beecham Plc | Novel compounds |
TW272942B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-02-10 | 1996-03-21 | Takeda Pharm Industry Co Ltd | |
DK41193D0 (da) | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
DE4322806A1 (de) | 1993-07-08 | 1995-01-12 | Janich Gmbh & Co | Vorrichtung zur Abdichtung zwischen zwei Anlagenteilen |
IL110296A (en) | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
US5378725A (en) | 1993-07-19 | 1995-01-03 | The Arizona Board Of Regents | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
US6514745B1 (en) | 1993-07-19 | 2003-02-04 | The Regents Of The University Of California | Oncoprotein protein kinase |
NZ264063A (en) | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
US5441947A (en) | 1993-08-25 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting vascular restenosis |
US5468773A (en) | 1993-08-25 | 1995-11-21 | Eli Lilly And Company | Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs |
US5504103A (en) | 1993-08-25 | 1996-04-02 | Eli Lilly And Company | Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof |
US5869043A (en) | 1993-09-17 | 1999-02-09 | Smithkline Beecham Corporation | Drug binding protein |
US6361773B1 (en) | 1993-09-17 | 2002-03-26 | Smithkline Beecham Corporation | Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins |
US5783664A (en) | 1993-09-17 | 1998-07-21 | Smithkline Beecham Corporation | Cytokine suppressive anit-inflammatory drug binding proteins |
ES2140561T3 (es) | 1993-09-17 | 2000-03-01 | Smithkline Beecham Corp | Proteina de union de farmacos. |
US5547966A (en) | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
CA2133815A1 (en) | 1993-10-12 | 1995-04-13 | Jeffrey Alan Dodge | Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof |
US5596001A (en) | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
DE69433501T2 (de) | 1993-11-08 | 2004-11-04 | Smithkline Beecham Corp. | Oxazole zur behandlung von zytokinvermittelten erkrankungen |
JPH07141053A (ja) | 1993-11-17 | 1995-06-02 | Nec Niigata Ltd | クロック発生回路 |
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
CH686211A5 (de) | 1994-01-27 | 1996-02-15 | Ciba Geigy Ag | Motten- und Koferschutzmittel. |
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
DE4412334A1 (de) | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US5559137A (en) | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US5744362A (en) | 1994-05-31 | 1998-04-28 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
US5656612A (en) | 1994-05-31 | 1997-08-12 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
US5470882A (en) | 1994-06-02 | 1995-11-28 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
WO1995033458A1 (en) | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Anti-inflammatory compounds |
US5447957A (en) | 1994-06-02 | 1995-09-05 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
US5786362A (en) | 1994-06-16 | 1998-07-28 | University Of Miami | Method of treating Hormone independent cancer |
EP0690344A1 (en) | 1994-06-29 | 1996-01-03 | Konica Corporation | Silver halide color photographic light-sensitive material |
US5480906A (en) | 1994-07-01 | 1996-01-02 | Eli Lilly And Company | Stereochemical Wortmannin derivatives |
FR2722319B1 (fr) | 1994-07-08 | 1996-08-14 | Thomson Csf | Dispositif de visualisation couleurs |
US5597719A (en) | 1994-07-14 | 1997-01-28 | Onyx Pharmaceuticals, Inc. | Interaction of RAF-1 and 14-3-3 proteins |
KR970706242A (ko) | 1994-10-04 | 1997-11-03 | 후지야마 아키라 | 우레아 유도체 및 ACAT-억제제로서 그의 용도(Urea derivatives and their use as ACAT-inhibitors) |
ATE220661T1 (de) | 1994-10-19 | 2002-08-15 | Novartis Erfind Verwalt Gmbh | Antivirale ether von aspartat-protease-substrat- isosteren |
CA2161376C (en) | 1994-10-27 | 2005-01-11 | Toshiaki Minami | Reversible multi-color thermal recording medium |
ES2158954T3 (es) | 1994-10-28 | 2001-09-16 | Novozymes As | Proceso para el apresto quimico de polimeros insolubles. |
TW313568B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
FR2729567B1 (fr) * | 1995-01-20 | 1997-06-13 | Oreal | Composition de teinture d'oxydation des fibres keratiniques et procede de teinture mettant en oeuvre cette composition |
JPH11503110A (ja) | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体拮抗剤 |
US5780483A (en) | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US5624937A (en) | 1995-03-02 | 1997-04-29 | Eli Lilly And Company | Chemical compounds as inhibitors of amyloid beta protein production |
US5814646A (en) | 1995-03-02 | 1998-09-29 | Eli Lilly And Company | Inhibitors of amyloid beta-protein production |
DE19512639A1 (de) | 1995-04-05 | 1996-10-10 | Merck Patent Gmbh | Benzonitrile und -fluoride |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5710173A (en) | 1995-06-07 | 1998-01-20 | Sugen, Inc. | Thienyl compounds for inhibition of cell proliferative disorders |
US5773459A (en) | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
IL118544A (en) | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
HUP9602538A3 (en) | 1995-09-18 | 1997-08-28 | Sankyo Co | New urea and amide derivatives having acat inhibitory activity, their preparation and their use |
US6075040A (en) | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
SE510846C2 (sv) | 1995-11-06 | 1999-06-28 | Moelnlycke Health Care Ab | Innerförpackning för i en yttre förpackning sterilförpackade bukdukar |
EP0860433B1 (en) | 1995-11-07 | 2002-07-03 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same |
EP0882715B1 (en) | 1995-12-28 | 2003-04-23 | Kureha Kagaku Kogyo Kabushiki Kaisha | Novel n-(unsubstituted or substituted)-4-substituted-6-(unsubstituted or substituted)phenoxy-2-pyridinecarboxamides or thiocarboxamides, processes for producing the same, and herbicides |
US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
US6005008A (en) | 1996-02-16 | 1999-12-21 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
US6103692A (en) | 1996-03-12 | 2000-08-15 | The General Hospital Corporation | Inhibiting protein interactions |
US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US5891895A (en) | 1996-04-15 | 1999-04-06 | Takeda Chemical Industries, Ltd. | Hydroxypyridine derivatives their production and use |
WO1997040028A1 (en) | 1996-04-23 | 1997-10-30 | Vertex Pharmaceuticals Incorporated | Urea derivatives as inhibitors of impdh enzyme |
US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
JPH09301858A (ja) | 1996-05-13 | 1997-11-25 | Senju Pharmaceut Co Ltd | グルコン酸クロルヘキシジン安定化水性薬剤 |
NZ332789A (en) | 1996-05-24 | 2000-05-26 | Neurosearch As | Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers |
US5910417A (en) | 1996-05-31 | 1999-06-08 | National Jewish Center For Immunology And Respiratory Medicine | Regulation of cytokine production in a hematopoietic cell |
EP0932405A4 (en) | 1996-06-27 | 2001-10-17 | Smithkline Beckman Corp | IL-8 RECEPTOR ANTAGONISTS |
JP2000514789A (ja) | 1996-06-27 | 2000-11-07 | スミスクライン・ビーチャム・コーポレイション | Il―8受容体拮抗薬 |
CZ425598A3 (cs) | 1996-06-27 | 1999-08-11 | Smithkline Beecham Corporation | Antagonista IL-8 receptoru |
JP2000513359A (ja) | 1996-06-27 | 2000-10-10 | スミスクライン・ビーチャム・コーポレイション | Il―8受容体拮抗薬 |
US6150415A (en) | 1996-08-13 | 2000-11-21 | The Regents Of The University Of California | Epoxide hydrolase complexes and methods therewith |
US6019793A (en) | 1996-10-21 | 2000-02-01 | Synthes | Surgical prosthetic device |
JP2001510450A (ja) | 1996-10-23 | 2001-07-31 | ザイモジェネティクス,インコーポレイテッド | 骨欠損状態を処置するための組成物および方法 |
US5965573A (en) | 1996-10-23 | 1999-10-12 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
ES2339306T3 (es) | 1996-11-15 | 2010-05-18 | Cytokine Pharmasciences, Inc. | Guanilhidrazonas utiles en el tratamiento de las enfermedades asociadas con la activacion de las celulas t. |
GB9623833D0 (en) | 1996-11-16 | 1997-01-08 | Zeneca Ltd | Chemical compound |
WO1998022432A1 (fr) | 1996-11-18 | 1998-05-28 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'acylanilide a substitution acylamino ou composition comprenant ces derives |
FR2755967B1 (fr) | 1996-11-21 | 1999-01-29 | Pf Medicament | Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments |
US5929250A (en) | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AU726858B2 (en) | 1997-01-23 | 2000-11-23 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
DE19706061A1 (de) | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
WO1998034929A1 (en) | 1997-02-12 | 1998-08-13 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
HUP0001243A3 (en) | 1997-04-04 | 2000-10-30 | Pfizer Prod Inc | Nicotinamide derivatives and pharmaceutical compositions containing them |
DE69811062T2 (de) | 1997-04-10 | 2003-07-17 | Pharmacia & Upjohn Co., Kalamazoo | Polyaromatische antivirale zusammensetzungen |
AU7080298A (en) | 1997-04-25 | 1998-11-24 | Takeda Chemical Industries Ltd. | Triazine derivatives, their production and agrochemical composition |
US6210710B1 (en) | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
AR012634A1 (es) | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
JP2002502380A (ja) | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | p38キナーゼ阻害剤としてのピラゾール誘導体 |
AR037061A1 (es) | 1997-05-22 | 2004-10-20 | Searle & Co | Compuesto derivado de pirazol sustituido, procesos para preparar dicho compuesto, composicion farmaceutica que lo contiene y su uso en la preparacion de medicamentos |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
AU7585598A (en) | 1997-05-23 | 1998-12-11 | Bayer Corporation | Raf kinase inhibitors |
US6187799B1 (en) | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
EP1019040B1 (en) | 1997-05-23 | 2004-09-29 | Bayer Corporation | Aryl ureas for the treatment of inflammatory or immunomodulatory diseases |
US6344476B1 (en) | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US6150395A (en) | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
US5985592A (en) | 1997-06-05 | 1999-11-16 | Dalhousie University | Uses for pentoxifylline or functional derivatives/metabolites thereof |
EP1023066A4 (en) | 1997-06-13 | 2001-05-23 | Smithkline Beecham Corp | NEW PYRAZOLE AND PYRAZOLINE SUBSTITUTED COMPOUND |
CA2294076A1 (en) | 1997-06-27 | 1999-01-07 | Kureha Kagaku Kogyo Kabushiki Kaisha | 6-phenoxypicolinic acid, alkylidenehydrazide derivatives, process for producing the same, and herbicide |
US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
US6525065B1 (en) | 1997-06-30 | 2003-02-25 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
AUPP003197A0 (en) | 1997-09-03 | 1997-11-20 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
UA71555C2 (en) | 1997-10-06 | 2004-12-15 | Zentaris Gmbh | Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives |
AU9802198A (en) | 1997-10-21 | 1999-05-10 | Pharmacia & Upjohn Company | Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors |
JP4555468B2 (ja) | 1997-10-31 | 2010-09-29 | アベンテイス・フアルマ・リミテツド | 置換アニリド |
EP1028953A1 (en) | 1997-11-03 | 2000-08-23 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
US6018065A (en) | 1997-11-10 | 2000-01-25 | Advanced Technology Materials, Inc. | Method of fabricating iridium-based materials and structures on substrates, iridium source reagents therefor |
GB9723789D0 (en) | 1997-11-12 | 1998-01-07 | Zeneca Ltd | Chemical compounds |
WO1999026657A1 (en) | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
WO1999028305A1 (en) | 1997-12-01 | 1999-06-10 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
US6635421B1 (en) | 1997-12-09 | 2003-10-21 | Children's Medical Center Corporation | Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
US6174901B1 (en) | 1998-12-18 | 2001-01-16 | Amgen Inc. | Substituted pyridine and pyridazine compounds and methods of use |
SK282727B6 (sk) | 1997-12-19 | 2002-11-06 | Slovakofarma, A. S. | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
KR100571588B1 (ko) | 1997-12-22 | 2006-04-17 | 바이엘 코포레이션 | 치환 헤테로시클릭 우레아를 이용한 raf 키나제의 억제 |
DE69830513T2 (de) | 1997-12-22 | 2006-03-16 | Bayer Pharmaceuticals Corp., West Haven | HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN |
SK286564B6 (sk) | 1997-12-22 | 2009-01-07 | Bayer Corporation | Substituované arylmočoviny ako inhibítory rafkinázy a farmaceutický prípravok s ich obsahom |
EP1041982B1 (en) | 1997-12-22 | 2011-10-19 | Bayer HealthCare LLC | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US20070244120A1 (en) | 2000-08-18 | 2007-10-18 | Jacques Dumas | Inhibition of raf kinase using substituted heterocyclic ureas |
DE1043995T1 (de) | 1997-12-22 | 2001-06-07 | Bayer Corp., Pittsburgh | INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYLSUBSTITUIERTEN HARNSTOFFEN |
US20080300281A1 (en) | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
US20120046290A1 (en) | 1997-12-22 | 2012-02-23 | Jacques Dumas | Inhibition of p38 kinase activity using substituted heterocyclic ureas |
US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
TR200100918T2 (tr) | 1997-12-22 | 2001-06-21 | Bayer Corporation | Aril ve heteroaril sübstitüentli üreler kullanılarak RAF kinazın inhibe edilmesi |
AU1689999A (en) | 1997-12-25 | 1999-07-19 | Daiichi Pharmaceutical Co., Ltd. | Medicinal composition for percutaneous administration |
WO1999037604A2 (en) | 1998-01-21 | 1999-07-29 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
FR2774824B1 (fr) | 1998-02-09 | 2000-04-28 | Moving Magnet Tech | Actionneur lineaire ameliore |
CA2321479A1 (en) | 1998-02-18 | 1999-08-26 | Hilmar Meek Warenius | Treating cancer |
MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
US6413773B1 (en) | 1998-06-01 | 2002-07-02 | The Regents Of The University Of California | Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation |
UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
US6667340B1 (en) | 1998-06-26 | 2003-12-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibitors of phosphatidyl myo-inositol cycle |
US6352977B1 (en) | 1998-07-13 | 2002-03-05 | Aventis Pharma Limited | Substituted β-alanines |
EP1114039A1 (en) | 1998-09-18 | 2001-07-11 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF p38 |
US6383734B1 (en) | 1998-09-30 | 2002-05-07 | Advanced Research And Technology Institute, Inc. | Method to determine inhibition of PAK3 activation of Raf-1 |
US6130053A (en) | 1999-08-03 | 2000-10-10 | Cell Pathways, Inc. | Method for selecting compounds for inhibition of neoplastic lesions |
GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
EP1126842A2 (en) | 1998-11-06 | 2001-08-29 | Basf Aktiengesellschaft | Inhibition of the formation of vascular hyperpermeability |
WO2000031238A2 (en) | 1998-11-25 | 2000-06-02 | Genetica, Inc. | Methods and reagents for increasing proliferative capacity and preventing replicative senescence |
US6114517A (en) | 1998-12-10 | 2000-09-05 | Isis Pharmaceuticals Inc. | Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules |
US6337338B1 (en) | 1998-12-15 | 2002-01-08 | Telik, Inc. | Heteroaryl-aryl ureas as IGF-1 receptor antagonists |
UY25842A1 (es) | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6331541B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6147107A (en) | 1998-12-20 | 2000-11-14 | Virginia Commonwealth University | Specific inhibition of the P42/44 mitogen activated protein (map) kinase cascade sensitizes tumor cells |
US20080269265A1 (en) | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
ATE301116T1 (de) | 1998-12-25 | 2005-08-15 | Teikoku Hormone Mfg Co Ltd | Aminopyrazol derivate |
EP2298311B1 (en) * | 1999-01-13 | 2012-05-09 | Bayer HealthCare LLC | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US20020065296A1 (en) | 1999-01-13 | 2002-05-30 | Bayer Corporation | Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors |
US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7351834B1 (en) | 1999-01-13 | 2008-04-01 | Bayer Pharmaceuticals Corporation | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
TWI284642B (en) | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
IL144461A0 (en) | 1999-01-22 | 2002-05-23 | Kirin Brewery | Quinoline and quinazoline derivatives and pharmaceutical compositions containing them |
ES2226785T3 (es) | 1999-02-12 | 2005-04-01 | Smithkline Beecham Plc | Derivados de fenilurea como antagonistas de los receptores de orexina. |
EP1157026A1 (en) | 1999-02-22 | 2001-11-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Polycyclo heterocyclic derivatives as antiinflammatory agents |
JP2002539206A (ja) | 1999-03-12 | 2002-11-19 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症剤としての芳香族複素環化合物 |
RU2242474C2 (ru) | 1999-03-12 | 2004-12-20 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | Соединения, пригодные в качестве противовоспалительных агентов |
PL211562B1 (pl) | 1999-03-19 | 2012-05-31 | Vertex Pharma | Związki, zawierające je kompozycje oraz ich zastosowania |
ATE467620T1 (de) | 1999-03-26 | 2010-05-15 | Euro Celtique Sa | Arylsubstituierte pyrazole, imidazole, oxazole, thiazole und pyrrole, sowie deren verwendung |
US6140124A (en) | 1999-04-06 | 2000-10-31 | Isis Pharmaceuticals Inc. | Antisense modulation of P38 mitogen activated protein kinase expression |
US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
EP1177186B1 (en) | 1999-05-05 | 2004-03-31 | Aventis Pharma Limited | Ureas and their use as cell adhesion modulators |
EP2042194A3 (en) | 1999-05-14 | 2009-04-22 | Imclone Systems, Inc. | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
HN2000000051A (es) | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
TWI234557B (en) | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
DE19927835A1 (de) | 1999-06-18 | 2000-12-21 | Clariant Gmbh | Verwendung von verbesserten Cyanpigmenten in elektrophotographischen Tonern und Entwicklern, Pulverlacken und Ink-Jet-Tinten |
DE60033407T2 (de) | 1999-07-09 | 2007-11-29 | Niigata Seimitsu Co., Ltd., Jouetsu | Vorrichtung zum erzeugen von wellenformdaten durch abgetastete funktionen |
EP1200411B1 (en) | 1999-07-09 | 2005-12-14 | Boehringer Ingelheim Pharmaceuticals Inc. | Process for synthesis of heteroaryl-substituted urea compounds |
EP1557168B1 (en) | 1999-07-26 | 2011-11-16 | Msd K.K. | Biarylurea Derivatives |
WO2001009088A1 (en) | 1999-07-28 | 2001-02-08 | Kirin Beer Kabushiki Kaisha | Urea derivatives as inhibitors of ccr-3 receptor |
US6387900B1 (en) | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
US6372933B1 (en) | 1999-08-26 | 2002-04-16 | Smithkline Beecham Corporation | Process for preparing certain phenyl urea compounds |
WO2001054727A1 (en) | 1999-10-15 | 2001-08-02 | The Van Kampen Group, Inc. | Treatment of dermal tumors, warts, and viral infections using heat-killed p. acnes |
ATE375334T1 (de) | 1999-11-16 | 2007-10-15 | Boehringer Ingelheim Pharma | Harnstoff derivate als entzündungshemmende mittel |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
US7740841B1 (en) | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
CA2398754A1 (en) | 2000-02-07 | 2001-08-09 | Abbott Gmbh & Co. Kg | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
WO2001064235A1 (en) | 2000-03-02 | 2001-09-07 | Ludwig Institute For Cancer Research | Methods for treating, screening for, and detecting cancers expressing vascular endothelial growth factor d |
GB0005357D0 (en) | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
EP1275386A1 (en) | 2000-04-19 | 2003-01-15 | Fujisawa Pharmaceutical Co., Ltd. | Solid dispersion with improved absorbability |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US6403588B1 (en) | 2000-04-27 | 2002-06-11 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
WO2002007008A1 (en) | 2000-04-28 | 2002-01-24 | Ubink Cornelis Hubertus Johann | Network procurement system |
US6390102B1 (en) | 2000-07-14 | 2002-05-21 | General Electric Company | Silicone compositions for personal care products and method for making |
EP1311277A4 (en) | 2000-07-18 | 2004-08-25 | Joslin Diabetes Center Inc | METHODS OF FIBROSIS MODULATION |
CA2415131A1 (en) | 2000-07-24 | 2002-01-31 | Boehringer Ingelheim Pharmaceuticals, Inc. | Improved oral dosage formulations of 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea |
GT200100147A (es) | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
AU2001284742A1 (en) | 2000-08-04 | 2002-02-18 | Loma Linda University | Iron regulating protein-2 (IRP-2) as a diagnostic for neurodegenerative disease |
AU2001283237B2 (en) | 2000-08-11 | 2007-09-20 | Vertex Pharmaceuticals Incorporated | Pyridine derivatives as inhibitors of p38 |
US20020173507A1 (en) | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
EP1256587B1 (en) | 2000-08-17 | 2006-03-29 | The Kitasato Institute | Novel pseudoerythromycin derivatives |
CA2420363A1 (en) | 2000-08-31 | 2002-03-07 | Pfizer Products Inc. | Pyrazole derivatives and their use as protein kinase inhibitors |
AUPR034000A0 (en) | 2000-09-25 | 2000-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
EP1415987B1 (en) | 2000-10-20 | 2007-02-28 | Eisai R&D Management Co., Ltd. | Nitrogenous aromatic ring compounds as anti cancer agents |
JP3768800B2 (ja) | 2000-10-31 | 2006-04-19 | キヤノン株式会社 | 画像形成装置 |
EP1345890A1 (en) | 2000-11-17 | 2003-09-24 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
CN1525889A (zh) | 2000-11-27 | 2004-09-01 | ����ˡ�A�������� | 分类物品的系统、方法及程序 |
DE60123461T2 (de) | 2000-11-28 | 2007-02-15 | Pfizer Products Inc., Groton | Salze eines 4-isothiazolcarboxamids und ihre verwendung als anti-hyperproliferationsmittel |
US7238813B2 (en) | 2000-11-29 | 2007-07-03 | Smithkline Beecham Corporation | Chemical compounds |
CN1492874A (zh) | 2000-12-21 | 2004-04-28 | 大环内酯 | |
KR100362390B1 (ko) | 2000-12-29 | 2002-11-23 | 삼성전자 주식회사 | 화상형성장치의 현상기-토너 카트리지 조립체 |
US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1360173A2 (en) | 2001-01-25 | 2003-11-12 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
WO2002059081A2 (en) | 2001-01-26 | 2002-08-01 | Kirin Beer Kabushiki Kaisha | Urea derivatives as inhibitors of ccr-3 receptor |
FR2820136A1 (fr) | 2001-01-26 | 2002-08-02 | Aventis Pharma Sa | Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
US6670364B2 (en) | 2001-01-31 | 2003-12-30 | Telik, Inc. | Antagonists of MCP-1 function and methods of use thereof |
SI3351246T1 (sl) | 2001-02-19 | 2019-08-30 | Novartis Pharma Ag | Derivat rapamicina za zdravljenje trdnega tumorja, povezanega z deregulirano angiogenezo |
UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
US6525091B2 (en) | 2001-03-07 | 2003-02-25 | Telik, Inc. | Substituted diarylureas as stimulators for Fas-mediated apoptosis |
DE60221104T2 (de) | 2001-03-07 | 2008-03-13 | TELIK, INC., Palo Alto | Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose |
EP1370552B1 (en) | 2001-03-23 | 2007-02-14 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
JP2005507367A (ja) | 2001-04-13 | 2005-03-17 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 1,4−二置換ベンゾ縮合化合物 |
MXPA03009361A (es) | 2001-04-13 | 2004-01-29 | Boehringer Ingelheim Pharma | Compuestos de urea utilies como agentes anti-inflamatorios. |
CA2443950C (en) | 2001-04-20 | 2011-10-18 | Bayer Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
US7371763B2 (en) | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
US20030207914A1 (en) | 2001-04-20 | 2003-11-06 | Bayer Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
CA2445357A1 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Pyrazole derived kinase inhibitors |
EP1392661A1 (en) | 2001-05-16 | 2004-03-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
WO2003005999A2 (en) | 2001-07-11 | 2003-01-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediated diseases |
US7371736B2 (en) | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
SE0103838D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Pharmaceutical formulation & product |
ES2400070T3 (es) | 2001-12-03 | 2013-04-05 | Bayer Healthcare Llc | Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos |
ES1050706Y (es) | 2001-12-12 | 2002-08-16 | Climastar Thermostone S L | Convector electrico mejorado |
BRPI0214840B8 (pt) | 2001-12-21 | 2021-05-25 | The Wellcome Trust | métodos para a detecção de mutações oncogênicas humanas, métodos automatizados para detectar uma mutação e método e ensaio para identificar um ou mais compostos tendo atividade anti-proliferativa |
WO2003060111A2 (en) | 2001-12-24 | 2003-07-24 | Catalyst Biomedica Limited | Cancer-specific mutants of b-raf genes and uses thereof |
US20040096855A1 (en) | 2001-12-24 | 2004-05-20 | Michael Stratton | Genes |
US20030207872A1 (en) | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US20080108672A1 (en) | 2002-01-11 | 2008-05-08 | Bernd Riedl | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors |
WO2003059373A2 (en) | 2002-01-16 | 2003-07-24 | Ramot At Tel Aviv University Ltd. | Compositions and their use for enhancing and inhibiting fertilization |
MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
US6924290B2 (en) | 2002-01-23 | 2005-08-02 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
US6998391B2 (en) | 2002-02-07 | 2006-02-14 | Supergen.Inc. | Method for treating diseases associated with abnormal kinase activity |
SI1580188T1 (sl) | 2002-02-11 | 2012-02-29 | Bayer Healthcare Llc | Aril sečnine kot kinazni inhibitorji |
US7928277B1 (en) | 2002-02-11 | 2011-04-19 | Cox Jr Henry Wilmore | Method for reducing contamination |
PT1478358E (pt) | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
US8299108B2 (en) | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
TW200406374A (en) | 2002-05-29 | 2004-05-01 | Novartis Ag | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases |
WO2004019941A1 (en) | 2002-08-27 | 2004-03-11 | Merck Patent Gmbh | Glycinamide derivatives as raf-kinase inhibitors |
US20060160856A1 (en) | 2002-09-05 | 2006-07-20 | Dahl Bjarne H | Diarylurea derivatives and their use as chloride channel blockers |
RU2005115842A (ru) | 2002-10-24 | 2006-03-10 | Мерк Патент ГмбХ (DE) | Производные метиленмочевины |
CA2504933C (en) | 2002-11-06 | 2012-10-16 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for treating cancer using proteasome inhibitors |
MXPA05005196A (es) | 2002-11-15 | 2005-07-22 | Novartis Ag | Sistema de suministro de farmacos. |
SE0203654D0 (sv) | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
US20030232400A1 (en) | 2002-12-20 | 2003-12-18 | Susan Radka | Methods of screening subjects for expression of soluble receptors of vascular endothelial growth factor (VEGF) for use in managing treatment and determining prognostic outcome |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
GB0317227D0 (en) | 2003-07-23 | 2003-08-27 | Pfizer Ltd | Treatment of male sexual dysfunction |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
WO2004078746A2 (en) * | 2003-02-28 | 2004-09-16 | Bayer Pharmaceuticals Corporation | 2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatrory disorders |
JP5229853B2 (ja) | 2003-02-28 | 2013-07-03 | ニッポネックス インコーポレイテッド | 癌その他の疾患の治療に有用な新規な二環尿素誘導体 |
MXPA05009102A (es) | 2003-02-28 | 2006-05-31 | Bayer Pharmaceuticals Corp | Derivados de piridina sustituida utiles en el tratamiento del cancer y otros trastornos. |
US7531553B2 (en) | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
KR20050110693A (ko) | 2003-03-24 | 2005-11-23 | 메르크 파텐트 게엠베하 | Raf-키나아제 억제제로서 유용한 옥사미드 유도체 |
US6896863B2 (en) | 2003-04-01 | 2005-05-24 | E. I. Du Pont De Nemours And Company | Sodium cyanide process |
ATE366108T1 (de) | 2003-05-20 | 2007-07-15 | Bayer Pharmaceuticals Corp | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
CA2527573A1 (en) | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | Cycloalkyl and heterocycloalkyl substituted benzothiophenes as therapeutic agents |
US20040259926A1 (en) | 2003-06-05 | 2004-12-23 | Bruendl Michelle M. | 3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents |
GB2403151A (en) | 2003-06-27 | 2004-12-29 | Intermark Medical Innovations | A device for rectal lavage |
WO2005002673A1 (en) | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
AU2004255566B2 (en) | 2003-07-07 | 2010-07-08 | Merk Patent Gmbh | Malonamide derivatives |
US20060173033A1 (en) | 2003-07-08 | 2006-08-03 | Michaela Kneissel | Use of rapamycin and rapamycin derivatives for the treatment of bone loss |
ES2465624T3 (es) | 2003-07-11 | 2014-06-06 | Merck Patent Gmbh | Benzimidazol carboxamidas como inhibidores de RAF quinasa |
EP1648900A4 (en) | 2003-07-11 | 2010-02-10 | Ariad Pharma Inc | PHOSPHORUS MACROCYCLES |
ES2380201T3 (es) | 2003-07-11 | 2012-05-09 | Merck Patent Gmbh | Derivados de benzimidazol |
US20060234931A1 (en) | 2003-07-17 | 2006-10-19 | Biggs William H Iii | Treatment of diseases with kinase inhibitors |
GB0317229D0 (en) | 2003-07-23 | 2003-08-27 | Pfizer Ltd | Improved process |
DK1663978T3 (da) | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
TW200523262A (en) | 2003-07-29 | 2005-07-16 | Smithkline Beecham Corp | Inhibitors of AKT activity |
DE10334663A1 (de) | 2003-07-30 | 2005-03-10 | Merck Patent Gmbh | Harnstoffderivate |
JP2007505938A (ja) | 2003-09-23 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | Vegf受容体阻害剤と化学療法剤の組み合わせ |
DE10344223A1 (de) | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
US20080045546A1 (en) | 2003-10-15 | 2008-02-21 | Axel Bouchon | Tetradydro-Naphthalene And Urea Derivatives |
KR20060118472A (ko) | 2003-10-16 | 2006-11-23 | 카이론 코포레이션 | 치환 벤자졸 및 raf 키나아제의 저해제로서 그것의 사용 |
EP1680122A1 (en) | 2003-10-16 | 2006-07-19 | Chiron Corporation | 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines as inhibitors of raf kinase for the treatment of cancer |
DE10349587A1 (de) | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
DE10352979A1 (de) | 2003-11-13 | 2005-06-09 | Merck Patent Gmbh | Pyridopyrimidinone |
CA2545711A1 (en) | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Urea derivatives as kinase modulators |
DE10354060A1 (de) | 2003-11-19 | 2005-06-02 | Merck Patent Gmbh | Pyrrolderivate |
KR20060123463A (ko) | 2003-12-09 | 2006-12-01 | 더 거번먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 레프리젠티드 바이 더 세크러터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 | 면역 반응을 억제하거나 증식성 장애를 치료하는 방법들 |
AU2004299174A1 (en) | 2003-12-10 | 2005-06-30 | Merck Patent Gmbh | Diacylhydrazine derivatives |
EP1730111A2 (en) | 2004-01-30 | 2006-12-13 | MERCK PATENT GmbH | Substituted bisarylurea derivatives as kinase inhibitors |
CA2560269A1 (en) | 2004-03-19 | 2005-09-29 | The Penn State Research Foundation | Combinatorial methods and compositions for treatment of melanoma |
JP2007535565A (ja) | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | 癌の治療に有用な置換ピラゾリル尿素誘導体 |
MY191349A (en) | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
JP5128948B2 (ja) | 2004-08-27 | 2013-01-23 | ニッポネックス インコーポレイテッド | 癌の治療のための新規な薬剤組成物 |
EP1797096B1 (en) | 2004-09-06 | 2011-07-27 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines as inhibitors of protein kinase b (akt) |
KR101381454B1 (ko) | 2004-09-29 | 2014-04-04 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 열역학적으로 안정한 형태의 bay 43-9006 토실레이트 |
JP2008514657A (ja) | 2004-09-29 | 2008-05-08 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 4−{4−[({[4−クロロ−3−(トリフルオロメチル)フェニル]アミノ}カルボニル)アミノ]フェノキシ}−n−メチルピリジン−2−カルボキサミドの製造方法 |
PT1858877E (pt) | 2005-01-14 | 2014-06-05 | Gilead Connecticut Inc | Ureias substituídas 1,3 diarilo, moduladoras da atividade de quinase |
ATE482693T1 (de) | 2005-03-07 | 2010-10-15 | Bayer Schering Pharma Ag | Pharmazeutische zusammensetzung mit einem omega- carboxyaryl-substituierten diphenylharnstoff zur behandlung von krebs |
DE102005015253A1 (de) | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | Pyrazolderivate |
BRPI0610048A2 (pt) | 2005-05-27 | 2010-05-25 | Bayer Healthcare Ag | terapia de combinação que compreende um composto de diaril uréia e uma pi3, akt quinase ou inibidores de mtor (rapamicinas) para o tratamento de cáncer |
US20090306020A1 (en) | 2005-05-27 | 2009-12-10 | Bayer Healthcare Ag | Combination therapy comprising diaryl ureas for treating diseases |
WO2007015947A2 (en) | 2005-07-29 | 2007-02-08 | Bayer Healthcare Llc | Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies |
WO2007039404A1 (en) | 2005-09-21 | 2007-04-12 | Nycomed Gmbh | Novel sulphonylpyrroles as inhibitors of hdac s novel sulphonylpyrroles |
EP1946115A4 (en) | 2005-10-21 | 2009-12-02 | Bayer Healthcare Llc | METHOD FOR PREDICTING AND FORECASTING CANCER AND MONITORING CANCER THERAPY |
US8329408B2 (en) | 2005-10-31 | 2012-12-11 | Bayer Healthcare Llc | Methods for prognosis and monitoring cancer therapy |
US20090068146A1 (en) | 2005-10-31 | 2009-03-12 | Scott Wilhelm | Diaryl ureas and combinations |
EP1954272A2 (en) | 2005-10-31 | 2008-08-13 | Bayer Pharmaceuticals Corporation | Treatment of cancer with sorafenib |
BRPI0618092A2 (pt) | 2005-11-02 | 2011-08-16 | Bayer Healthcare Llc | métodos "in vitro" para monitorar o estado de uma doença, de seleção de terapia e de diagnóstico de cáncer |
KR20080067000A (ko) | 2005-11-10 | 2008-07-17 | 바이엘 헬스케어 아게 | 폐 고혈압을 치료하기 위한 디아릴 우레아 |
DE602006019468D1 (de) | 2005-11-10 | 2011-02-17 | Bayer Schering Pharma Ag | Diarylharnstoffe zur behandlung von pulmonaler hypertonie |
MX2008006239A (es) | 2005-11-14 | 2008-12-12 | Bayer Healthcare Llc | Metodos para prediccion y pronostico de cancer y monitoreo de terapia contra el cancer. |
WO2007059155A1 (en) | 2005-11-14 | 2007-05-24 | Bayer Pharmaceuticals Corporation | Treatment of cancers having resistance to chemotherapeutic agents |
JP2009515978A (ja) | 2005-11-14 | 2009-04-16 | バイエル ヘルスケア エルエルシー | Kit阻害剤に対する獲得耐性を伴う癌の治療 |
US20110195110A1 (en) | 2005-12-01 | 2011-08-11 | Roger Smith | Urea compounds useful in the treatment of cancer |
WO2007068380A1 (en) | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl urea for treating virus infections |
JP2009524585A (ja) | 2005-12-15 | 2009-07-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ウイルス感染を処置するためのジアリールウレア |
US20090227637A1 (en) | 2005-12-15 | 2009-09-10 | Olaf Weber | Diaryl ureas for treating virus infections |
CA2634084C (en) | 2005-12-21 | 2015-04-07 | Roger Smith | Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders |
WO2007087575A2 (en) | 2006-01-24 | 2007-08-02 | University Of Chicago | Compositions and methods for treating pulmonary hypertension |
JP2009532029A (ja) | 2006-03-31 | 2009-09-10 | バイエル・ヘルスケア・エルエルシー | 癌の予報および予後方法および癌治療のモニタリング |
MX2008014953A (es) | 2006-05-26 | 2009-03-05 | Bayer Healthcare Llc | Combinaciones de medicamentos con diarilureas sustituidas para el tratamiento de cancer. |
AR062927A1 (es) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
EP2081902A1 (en) | 2006-11-09 | 2009-07-29 | Bayer Schering Pharma Aktiengesellschaft | Polymorph iii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide |
EP2089003A1 (en) | 2006-11-09 | 2009-08-19 | Abbott GmbH & Co. KG | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
EP2089363A1 (en) | 2006-11-14 | 2009-08-19 | Bayer Schering Pharma Aktiengesellschaft | Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]n-methylpyridine-2-carboxamide |
ATE498620T1 (de) | 2006-12-20 | 2011-03-15 | Bayer Healthcare Llc | 4-ä4-ä(ä3-tert-butyl-1-ä3-(hydroxymethyl)-pheny ü-1h-pyrazol-5-ylü-carbamoyl)-aminoü-3- fluorophenoxyü -n-methylpyridin-2-carboxamid sowie prodrugs und salze davon zur behandlung von krebs |
CA2672951A1 (en) | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | Hydroxy methyl phenyl pyrazolyl urea compound useful in the treatment of cancer |
JP2010516692A (ja) | 2007-01-19 | 2010-05-20 | バイエル・ヘルスケア・エルエルシー | 化学療法剤に対し抵抗性を有する癌の処置 |
CA2675980C (en) | 2007-01-19 | 2016-06-21 | Bayer Healthcare Llc | Use of dast for treatment of cancers with acquired resistance to kit inhibitors |
JP5058256B2 (ja) | 2007-06-21 | 2012-10-24 | シャープ株式会社 | 光検出装置、及びそれを備えた表示装置 |
JP5076072B2 (ja) | 2008-03-24 | 2012-11-21 | 矢崎総業株式会社 | 圧着端子、及びこの圧着端子を用いた圧着構造 |
JP2011525503A (ja) | 2008-06-25 | 2011-09-22 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 心不全を処置するためのジアリールウレア |
JP5439494B2 (ja) | 2008-10-21 | 2014-03-12 | バイエル ヘルスケア エルエルシー | 肝細胞癌と関連するシグネチャ遺伝子の同定 |
JP5077375B2 (ja) | 2010-02-26 | 2012-11-21 | 井関農機株式会社 | コンバイン |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
WO2003047523A2 (en) * | 2001-12-04 | 2003-06-12 | Onyx Pharmaceuticals, Inc. | Raf-mek-erk pathway inhibitors to treat cancer |
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