TR201910686T4 - Mrna iletimine yönelik lipit nanopartikül bileşimleri ve yöntemler. - Google Patents
Mrna iletimine yönelik lipit nanopartikül bileşimleri ve yöntemler. Download PDFInfo
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- TR201910686T4 TR201910686T4 TR2019/10686T TR201910686T TR201910686T4 TR 201910686 T4 TR201910686 T4 TR 201910686T4 TR 2019/10686 T TR2019/10686 T TR 2019/10686T TR 201910686 T TR201910686 T TR 201910686T TR 201910686 T4 TR201910686 T4 TR 201910686T4
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- methods
- lipid nanoparticle
- nanoparticle compositions
- mrna delivery
- compositions
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- 239000000203 mixture Substances 0.000 title abstract 3
- 150000002632 lipids Chemical class 0.000 title 1
- 108020004999 messenger RNA Proteins 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
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- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- C07K—PEPTIDES
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- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N9/6424—Serine endopeptidases (3.4.21)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Burada, bir hedef hücrede bir proteinin üretimini modüle etmeye yönelik bileşimler ve yöntemler açıklanmaktadır. Burada açıklanan bileşimler ve yöntemler, protein veya enzim eksiklikleri ile bağlantılı hastalıkları iyileştirebilir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161494881P | 2011-06-08 | 2011-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201910686T4 true TR201910686T4 (tr) | 2019-08-21 |
Family
ID=46317537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10686T TR201910686T4 (tr) | 2011-06-08 | 2012-06-08 | Mrna iletimine yönelik lipit nanopartikül bileşimleri ve yöntemler. |
Country Status (28)
Country | Link |
---|---|
US (22) | US20140206753A1 (tr) |
EP (3) | EP4043025A1 (tr) |
JP (6) | JP6184945B2 (tr) |
KR (3) | KR102128248B1 (tr) |
CN (3) | CN103906527B (tr) |
AU (4) | AU2012267531B2 (tr) |
BR (1) | BR112013031553A2 (tr) |
CA (2) | CA3107288A1 (tr) |
CL (1) | CL2013003478A1 (tr) |
CY (1) | CY1122123T1 (tr) |
DK (2) | DK3586861T3 (tr) |
ES (2) | ES2911653T3 (tr) |
HK (1) | HK1199206A1 (tr) |
HR (1) | HRP20191338T1 (tr) |
HU (1) | HUE044277T2 (tr) |
IL (3) | IL280771B2 (tr) |
LT (1) | LT2717893T (tr) |
ME (1) | ME03491B (tr) |
MX (2) | MX367605B (tr) |
NZ (1) | NZ719345A (tr) |
PE (1) | PE20140797A1 (tr) |
PL (2) | PL3586861T3 (tr) |
PT (2) | PT3586861T (tr) |
RS (1) | RS59037B1 (tr) |
RU (1) | RU2013154295A (tr) |
SI (1) | SI2717893T1 (tr) |
TR (1) | TR201910686T4 (tr) |
WO (1) | WO2012170930A1 (tr) |
Families Citing this family (332)
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AU2009311667B2 (en) | 2008-11-07 | 2016-04-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
NZ600616A (en) | 2009-12-01 | 2014-11-28 | Shire Human Genetic Therapies | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
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2022
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- 2022-06-03 US US17/832,202 patent/US20220362406A1/en not_active Abandoned
-
2023
- 2023-04-03 US US18/295,150 patent/US11951179B2/en active Active
- 2023-04-03 US US18/295,152 patent/US11951180B2/en active Active
- 2023-04-03 US US18/295,139 patent/US20230293723A1/en not_active Abandoned
- 2023-04-03 US US18/295,159 patent/US11951181B2/en active Active
- 2023-05-08 JP JP2023076542A patent/JP2023087094A/ja active Pending
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