SK285256B6 - O-Alkylovaný derivát rapamycínu, farmaceutická kompozícia a jeho použitie, najmä ako imunosupresíva - Google Patents

O-Alkylovaný derivát rapamycínu, farmaceutická kompozícia a jeho použitie, najmä ako imunosupresíva Download PDF

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Publication number
SK285256B6
SK285256B6 SK465-95A SK46595A SK285256B6 SK 285256 B6 SK285256 B6 SK 285256B6 SK 46595 A SK46595 A SK 46595A SK 285256 B6 SK285256 B6 SK 285256B6
Authority
SK
Slovakia
Prior art keywords
hydroxy
rapamycin
ethylrapamycin
medicament
mmol
Prior art date
Application number
SK465-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK46595A3 (en
Inventor
Sylvain Cottens
Richard Sedrani
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10723188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK285256(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK46595A3 publication Critical patent/SK46595A3/sk
Publication of SK285256B6 publication Critical patent/SK285256B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SK465-95A 1992-10-09 1993-09-24 O-Alkylovaný derivát rapamycínu, farmaceutická kompozícia a jeho použitie, najmä ako imunosupresíva SK285256B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929221220A GB9221220D0 (en) 1992-10-09 1992-10-09 Organic componds
PCT/EP1993/002604 WO1994009010A1 (en) 1992-10-09 1993-09-24 O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants

Publications (2)

Publication Number Publication Date
SK46595A3 SK46595A3 (en) 1995-08-09
SK285256B6 true SK285256B6 (sk) 2006-10-05

Family

ID=10723188

Family Applications (2)

Application Number Title Priority Date Filing Date
SK49-2006A SK286054B6 (sk) 1992-10-09 1993-09-24 40-O-Hydroxy(C1-4)alkyl-, -hydroxy(C1-4)alkoxy(C1-4)alkyl-, -acyloamino(C1-4)alkyl- a -amino(C1-4)alkyl-rapamycín deriváty, farmaceutická kompozícia obsahujúca takéto zlúčeniny a použitie takýchto zlúčenín ako farmaceutík
SK465-95A SK285256B6 (sk) 1992-10-09 1993-09-24 O-Alkylovaný derivát rapamycínu, farmaceutická kompozícia a jeho použitie, najmä ako imunosupresíva

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK49-2006A SK286054B6 (sk) 1992-10-09 1993-09-24 40-O-Hydroxy(C1-4)alkyl-, -hydroxy(C1-4)alkoxy(C1-4)alkyl-, -acyloamino(C1-4)alkyl- a -amino(C1-4)alkyl-rapamycín deriváty, farmaceutická kompozícia obsahujúca takéto zlúčeniny a použitie takýchto zlúčenín ako farmaceutík

Country Status (28)

Country Link
US (2) US5665772A (ko)
EP (3) EP0867438B1 (ko)
JP (2) JP3117462B2 (ko)
KR (2) KR100308598B1 (ko)
AT (2) ATE173736T1 (ko)
AU (1) AU676198B2 (ko)
BR (1) BR1100353A (ko)
CA (2) CA2476257C (ko)
CY (2) CY2125B1 (ko)
CZ (1) CZ283333B6 (ko)
DE (3) DE69322282T2 (ko)
DK (2) DK0867438T3 (ko)
ES (2) ES2225919T3 (ko)
FI (2) FI109540B (ko)
FR (1) FR04C0012I2 (ko)
GB (1) GB9221220D0 (ko)
GE (1) GEP20002331B (ko)
HU (1) HU224074B1 (ko)
LU (1) LU91104I2 (ko)
NL (1) NL300154I2 (ko)
NO (3) NO307053B1 (ko)
NZ (1) NZ256026A (ko)
PL (1) PL176174B1 (ko)
PT (1) PT867438E (ko)
RO (1) RO114451B1 (ko)
RU (1) RU2143434C1 (ko)
SK (2) SK286054B6 (ko)
WO (1) WO1994009010A1 (ko)

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* Cited by examiner, † Cited by third party
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SPCY Application to extend an spc

Free format text: PRODUCT NAME: EVEROLIMUS; NAT. REGISTRATION NO/DATE: R-2291/2004 - R-2296/2004 20041216; FIRST REGISTRATION: SE 18690 - 18695 20030718

Spc suppl protection certif: 44 5008-2006

Filing date: 20160713

SPCZ Extension of validity of an spc

Free format text: PRODUCT NAME: EVEROLIMUS; NAT. REGISTRATION NO/DATE: R-2291/2004 - R-2296/2004 20041216; FIRST REGISTRATION: SE 18690 - 18695 20030718

Spc suppl protection certif: 44 5008-2006

Filing date: 20160713

Extension date: 20190118

SPCE Expiry of an spc

Spc suppl protection certif: 44 5008-2006

Effective date: 20190118