RU2331642C2 - Новые ингибиторы киназ - Google Patents

Новые ингибиторы киназ Download PDF

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Publication number
RU2331642C2
RU2331642C2 RU2005104422/04A RU2005104422A RU2331642C2 RU 2331642 C2 RU2331642 C2 RU 2331642C2 RU 2005104422/04 A RU2005104422/04 A RU 2005104422/04A RU 2005104422 A RU2005104422 A RU 2005104422A RU 2331642 C2 RU2331642 C2 RU 2331642C2
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RU
Russia
Prior art keywords
yloxy
methyl
indol
fluoro
methylpyrrolo
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RU2005104422/04A
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English (en)
Russian (ru)
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RU2005104422A (ru
Inventor
Раджив БХАЙД (US)
Раджив БХАЙД
Жен-Вей КАЙ (US)
Жен-Вей КАЙ
Лиганг КИАН (US)
Лиганг КИАН
Стефани БАРБОСА (US)
Стефани БАРБОСА
Луис ЛОМБАРДО (US)
Луис ЛОМБАРДО
Джеффри РОБЛ (US)
Джеффри РОБЛ
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Бристол-Маерс Сквибб Компани
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Publication of RU2331642C2 publication Critical patent/RU2331642C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
RU2005104422/04A 2002-07-19 2003-07-18 Новые ингибиторы киназ RU2331642C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39725602P 2002-07-19 2002-07-19
US60/397,256 2002-07-19
US44721303P 2003-02-13 2003-02-13
US60/447,213 2003-02-13

Publications (2)

Publication Number Publication Date
RU2005104422A RU2005104422A (ru) 2005-08-10
RU2331642C2 true RU2331642C2 (ru) 2008-08-20

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RU2005104422/04A RU2331642C2 (ru) 2002-07-19 2003-07-18 Новые ингибиторы киназ
RU2005104818/04A RU2005104818A (ru) 2002-07-19 2003-07-18 Азаиндольные ингибиторы киназ

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RU2005104818/04A RU2005104818A (ru) 2002-07-19 2003-07-18 Азаиндольные ингибиторы киназ

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EP (3) EP2280012A3 (enExample)
JP (2) JP4361485B2 (enExample)
KR (1) KR100901939B1 (enExample)
CN (3) CN1315833C (enExample)
AR (1) AR040500A1 (enExample)
AT (2) ATE537843T1 (enExample)
AU (2) AU2003254017A1 (enExample)
BR (2) BR0312801A (enExample)
CA (2) CA2492804C (enExample)
CO (1) CO5680407A2 (enExample)
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DE (1) DE60336732D1 (enExample)
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ES (1) ES2377963T3 (enExample)
GE (2) GEP20074213B (enExample)
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IL (3) IL166129A0 (enExample)
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PE (1) PE20040680A1 (enExample)
PL (2) PL216663B1 (enExample)
PT (1) PT1534290E (enExample)
RS (2) RS52325B (enExample)
RU (2) RU2331642C2 (enExample)
SI (1) SI1534290T1 (enExample)
TW (1) TWI329112B (enExample)
UA (1) UA82846C2 (enExample)
WO (2) WO2004009601A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2753056C2 (ru) * 2016-12-16 2021-08-11 Систик Файбросис Фаундейшн Бициклические гетероарильные производные в качестве стимуляторов cftr

Families Citing this family (211)

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DE69734362T2 (de) * 1996-12-03 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
DE69734871D1 (de) * 1997-05-30 2006-01-19 St Microelectronics Srl Verfahren zur Herstellung eines Germanium-implantierten bipolaren Heteroübergangtransistors
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
KR101025675B1 (ko) * 2002-04-23 2011-03-30 브리스톨-마이어스 스큅 컴퍼니 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물
TW200306841A (en) 2002-04-23 2003-12-01 Bristol Myers Squibb Co Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
ATE350383T1 (de) * 2002-08-23 2007-01-15 Sloan Kettering Inst Cancer Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
TW200420565A (en) 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
KR20050099525A (ko) 2003-02-05 2005-10-13 브리스톨-마이어스 스큅 컴퍼니 피롤로트리아진 키나제 억제제의 제조 방법
EP1648998B1 (en) 2003-07-18 2014-10-01 Amgen Inc. Specific binding agents to hepatocyte growth factor
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
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