EA199800912A1 - Дигидратная соль мезилата 5-(2-(4-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2(1н)-индол-2-она, фармацевтическая композиция и способ лечения психотического расстройства - Google Patents

Дигидратная соль мезилата 5-(2-(4-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2(1н)-индол-2-она, фармацевтическая композиция и способ лечения психотического расстройства

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Publication number
EA199800912A1
EA199800912A1 EA199800912A EA199800912A EA199800912A1 EA 199800912 A1 EA199800912 A1 EA 199800912A1 EA 199800912 A EA199800912 A EA 199800912A EA 199800912 A EA199800912 A EA 199800912A EA 199800912 A1 EA199800912 A1 EA 199800912A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperazinyl
dihydro
treatment
disorders
psychotical
Prior art date
Application number
EA199800912A
Other languages
English (en)
Other versions
EA001190B1 (ru
Inventor
Фрэнк Роберт Буш
Кэрол Энн Роуз
Расселл Джеймс Шайн
Original Assignee
Пфайзер Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк filed Critical Пфайзер Инк
Publication of EA199800912A1 publication Critical patent/EA199800912A1/ru
Publication of EA001190B1 publication Critical patent/EA001190B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к дигидратным солям мезилата 5-(2-(4-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2Н-индол-2-она, фармацевтическим композициям, содержащим указанные дигидратные соли мезилата, а также к способам применения дигидратов мезилата для лечения психотических расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800912A 1996-05-07 1997-04-10 Дигидратная соль мезилата 5-(2-(4-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2(1н)-индол-2-она, фармацевтическая композиция и способ лечения психотического расстройства EA001190B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1675796P 1996-05-07 1996-05-07
PCT/IB1997/000393 WO1997042191A1 (en) 1996-05-07 1997-04-10 Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2(1h)-indol-2-one (=ziprasidone), its preparation and its use as dopamine d2 antagonist

Publications (2)

Publication Number Publication Date
EA199800912A1 true EA199800912A1 (ru) 1999-04-29
EA001190B1 EA001190B1 (ru) 2000-12-25

Family

ID=21778804

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800912A EA001190B1 (ru) 1996-05-07 1997-04-10 Дигидратная соль мезилата 5-(2-(4-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2(1н)-индол-2-она, фармацевтическая композиция и способ лечения психотического расстройства

Country Status (41)

Country Link
US (1) US6245765B1 (ru)
EP (1) EP0918772B1 (ru)
JP (1) JP3494659B2 (ru)
KR (1) KR100333215B1 (ru)
CN (1) CN1091769C (ru)
AP (1) AP765A (ru)
AR (1) AR007004A1 (ru)
AT (1) ATE278689T1 (ru)
AU (1) AU731267B2 (ru)
BG (1) BG63544B1 (ru)
BR (1) BR9709889A (ru)
CA (1) CA2252898C (ru)
CO (1) CO4940466A1 (ru)
CZ (1) CZ289215B6 (ru)
DE (1) DE69731094T2 (ru)
DK (1) DK0918772T3 (ru)
DZ (1) DZ2222A1 (ru)
EA (1) EA001190B1 (ru)
EG (1) EG24076A (ru)
ES (1) ES2229342T3 (ru)
GT (1) GT199700052A (ru)
HK (1) HK1017892A1 (ru)
HR (1) HRP970236B1 (ru)
ID (1) ID16867A (ru)
IL (1) IL126591A (ru)
IS (1) IS2080B (ru)
MA (1) MA24171A1 (ru)
MY (1) MY119997A (ru)
NO (1) NO312514B1 (ru)
NZ (1) NZ332218A (ru)
OA (1) OA10909A (ru)
PL (1) PL188330B1 (ru)
PT (1) PT918772E (ru)
SI (1) SI0918772T1 (ru)
SK (1) SK282837B6 (ru)
TN (1) TNSN97074A1 (ru)
TR (1) TR199802240T2 (ru)
TW (1) TW491847B (ru)
UA (1) UA46840C2 (ru)
WO (1) WO1997042191A1 (ru)
ZA (1) ZA973876B (ru)

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HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
UA57734C2 (ru) 1996-05-07 2003-07-15 Пфайзер Інк. Комплексы включения арилгетероциклических солей
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
CZ20023860A3 (cs) * 2000-06-02 2004-01-14 Pfizer Products Inc. S-Methyldihydroziprasidon pro léčení psychických a očních poruch
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
UY27668A1 (es) 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
AU2004237951A1 (en) 2003-05-16 2004-11-25 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with GABA modulators, anticonvulsants or benzodiazapines
US7678799B2 (en) * 2003-06-03 2010-03-16 Teva Pharmaceutical Industries Ltd. Crystalline ziprasidone HCl and processes for preparation thereof
EP1628973A2 (en) 2003-10-24 2006-03-01 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
CA2565996A1 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
CA2467538C (en) 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
CA2471219A1 (en) 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
EP2623095A1 (en) * 2004-11-16 2013-08-07 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
EP1863806A1 (en) * 2005-02-11 2007-12-12 Teva Pharmaceutical Industries Ltd Amorphous ziprasidone mesylate
CA2591670A1 (en) * 2005-02-11 2006-08-17 Teva Pharmaceutical Industries Ltd. Process of preparing ziprasidone mesylate
CA2598288A1 (en) * 2005-03-03 2006-09-14 Elan Pharma International Limited Nanoparticulate compositions of heterocyclic amide derivatives
ITMI20050346A1 (it) 2005-03-07 2006-09-08 Dipharma Spa Forma solida di ziprasidone cloridrato
CA2500667C (en) 2005-03-11 2013-01-15 Apotex Pharmachem Inc. Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions
CA2599391A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
WO2006099452A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Anhydrous ziprasidone mesylate and a process for its preparation
ITMI20052216A1 (it) * 2005-11-18 2007-05-19 Dipharma Spa Procedimento per la preparazione di ziprasidone
CN101677568A (zh) * 2007-05-18 2010-03-24 赛多斯有限责任公司 齐拉西酮制剂
EP2321011A1 (en) * 2008-06-25 2011-05-18 Pfizer Inc. Diaryl compounds and uses thereof
CN103249416B (zh) * 2010-10-18 2019-06-04 大日本住友制药株式会社 注射用缓释制剂
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (6)

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MX173362B (es) 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5312925A (en) 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5206366A (en) 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5359068A (en) 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
AU730856C (en) 1996-05-07 2001-11-15 Pfizer Inc. Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol- 3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)- indol-2-one(=ziprasidone),it's preparation and it's use as dopamine D2 antagonist

Also Published As

Publication number Publication date
DE69731094D1 (de) 2004-11-11
DE69731094T2 (de) 2006-02-23
CA2252898A1 (en) 1997-11-13
IS2080B (is) 2006-02-15
BR9709889A (pt) 1999-08-10
BG63544B1 (bg) 2002-04-30
EA001190B1 (ru) 2000-12-25
HRP970236A2 (en) 1998-06-30
HRP970236B1 (en) 2002-12-31
IS4874A (is) 1998-10-20
SK150898A3 (en) 2000-02-14
ID16867A (id) 1997-11-20
US6245765B1 (en) 2001-06-12
CZ349398A3 (cs) 1999-09-15
CO4940466A1 (es) 2000-07-24
SI0918772T1 (en) 2005-02-28
KR100333215B1 (ko) 2002-06-20
AP9700976A0 (en) 1997-07-31
NO312514B1 (no) 2002-05-21
PT918772E (pt) 2004-12-31
CZ289215B6 (cs) 2001-12-12
EP0918772A1 (en) 1999-06-02
IL126591A0 (en) 1999-08-17
ATE278689T1 (de) 2004-10-15
IL126591A (en) 2001-11-25
ES2229342T3 (es) 2005-04-16
CN1216991A (zh) 1999-05-19
NO985194L (no) 1998-11-06
TNSN97074A1 (fr) 2005-03-15
BG102892A (en) 1999-09-30
EG24076A (en) 2008-05-11
OA10909A (en) 2001-10-26
AU2174797A (en) 1997-11-26
JP3494659B2 (ja) 2004-02-09
AR007004A1 (es) 1999-10-13
UA46840C2 (uk) 2002-06-17
KR20000010824A (ko) 2000-02-25
NO985194D0 (no) 1998-11-06
DK0918772T3 (da) 2005-01-10
TW491847B (en) 2002-06-21
WO1997042191A1 (en) 1997-11-13
MY119997A (en) 2005-08-30
ZA973876B (en) 1998-11-06
GT199700052A (es) 2001-08-29
MA24171A1 (fr) 1997-12-31
EP0918772B1 (en) 2004-10-06
JPH11509867A (ja) 1999-08-31
SK282837B6 (sk) 2002-12-03
HK1017892A1 (en) 1999-12-03
DZ2222A1 (fr) 2002-12-03
AP765A (en) 1999-09-17
NZ332218A (en) 2005-02-25
CN1091769C (zh) 2002-10-02
PL188330B1 (pl) 2005-01-31
TR199802240T2 (ru) 1999-02-22
CA2252898C (en) 2003-04-08
PL329884A1 (en) 1999-04-12
AU731267B2 (en) 2001-03-29

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