TNSN97074A1 - Dihydrates de mesylate de 5 - (2 - (4 - (1,2 - benzisothiazole - 3 - yl) - 1 - piperazinyl) ethyl) - 6 - chloro - 1,3 - dihydro - 2h - indole - 2 - one. - Google Patents

Dihydrates de mesylate de 5 - (2 - (4 - (1,2 - benzisothiazole - 3 - yl) - 1 - piperazinyl) ethyl) - 6 - chloro - 1,3 - dihydro - 2h - indole - 2 - one.

Info

Publication number
TNSN97074A1
TNSN97074A1 TNTNSN97074A TNSN97074A TNSN97074A1 TN SN97074 A1 TNSN97074 A1 TN SN97074A1 TN TNSN97074 A TNTNSN97074 A TN TNSN97074A TN SN97074 A TNSN97074 A TN SN97074A TN SN97074 A1 TNSN97074 A1 TN SN97074A1
Authority
TN
Tunisia
Prior art keywords
benzisothiazole
piperazinyl
indole
dihydro
chloro
Prior art date
Application number
TNTNSN97074A
Other languages
English (en)
Inventor
Robert Busch Frank
Anne Rose Carol
James Shine Russell
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN97074A1 publication Critical patent/TNSN97074A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'INVENTION CONCERNE LES DIHYDRATES DE MESYLATE DE 5 - (2 - (4-(1,2 - BENZISOTHIAZOLE -3 – YL) – 1 – PIPERAZINYL) ETHYL) – 6 – CHLORO - 1 ,3 – DIHYDRO – 2H – INDOLE – 2 – ONE. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTEANANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE TROUBLES PSYCHOTIQUES.
TNTNSN97074A 1996-05-07 1997-05-06 Dihydrates de mesylate de 5 - (2 - (4 - (1,2 - benzisothiazole - 3 - yl) - 1 - piperazinyl) ethyl) - 6 - chloro - 1,3 - dihydro - 2h - indole - 2 - one. TNSN97074A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1675796P 1996-05-07 1996-05-07

Publications (1)

Publication Number Publication Date
TNSN97074A1 true TNSN97074A1 (fr) 2005-03-15

Family

ID=21778804

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97074A TNSN97074A1 (fr) 1996-05-07 1997-05-06 Dihydrates de mesylate de 5 - (2 - (4 - (1,2 - benzisothiazole - 3 - yl) - 1 - piperazinyl) ethyl) - 6 - chloro - 1,3 - dihydro - 2h - indole - 2 - one.

Country Status (41)

Country Link
US (1) US6245765B1 (fr)
EP (1) EP0918772B1 (fr)
JP (1) JP3494659B2 (fr)
KR (1) KR100333215B1 (fr)
CN (1) CN1091769C (fr)
AP (1) AP765A (fr)
AR (1) AR007004A1 (fr)
AT (1) ATE278689T1 (fr)
AU (1) AU731267B2 (fr)
BG (1) BG63544B1 (fr)
BR (1) BR9709889A (fr)
CA (1) CA2252898C (fr)
CO (1) CO4940466A1 (fr)
CZ (1) CZ289215B6 (fr)
DE (1) DE69731094T2 (fr)
DK (1) DK0918772T3 (fr)
DZ (1) DZ2222A1 (fr)
EA (1) EA001190B1 (fr)
EG (1) EG24076A (fr)
ES (1) ES2229342T3 (fr)
GT (1) GT199700052A (fr)
HK (1) HK1017892A1 (fr)
HR (1) HRP970236B1 (fr)
ID (1) ID16867A (fr)
IL (1) IL126591A (fr)
IS (1) IS2080B (fr)
MA (1) MA24171A1 (fr)
MY (1) MY119997A (fr)
NO (1) NO312514B1 (fr)
NZ (1) NZ332218A (fr)
OA (1) OA10909A (fr)
PL (1) PL188330B1 (fr)
PT (1) PT918772E (fr)
SI (1) SI0918772T1 (fr)
SK (1) SK282837B6 (fr)
TN (1) TNSN97074A1 (fr)
TR (1) TR199802240T2 (fr)
TW (1) TW491847B (fr)
UA (1) UA46840C2 (fr)
WO (1) WO1997042191A1 (fr)
ZA (1) ZA973876B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
NZ551012A (en) * 2000-06-02 2008-04-30 Pfizer Prod Inc Use of S-methyl-dihydro-ziprasidone administered via either the oral, parenteral (such as subcutaneous, intravenous, intramuscular, intrasternal and infusion techniques), rectal, intranasal or topical routes in doses ranging from 0.5 to 500 mg per day
UY27668A1 (es) * 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
MXPA05012317A (es) 2003-05-16 2006-01-30 Pfizer Prod Inc Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores del gaba anticonvulsivos o benzodiazepinas.
CA2528100A1 (fr) 2003-06-03 2005-04-21 Teva Pharmaceutical Industries Ltd Formes polymorphes de ziprasidone chlorhydrate et procedes pour leur elaboration
US7667037B2 (en) 2003-10-24 2010-02-23 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
MXPA06013163A (es) * 2004-05-11 2007-02-13 Pfizer Prod Inc Combinacion de antipsicoticos atipicos y antagonistas del receptor 5-ht1b.
CA2467538C (fr) 2004-05-14 2010-08-24 Apotex Pharmachem Inc. Nouveau chlorhydrate de ziprasidone amorphe (chlorhydrate de 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydr o-2h-indol-2-one) et procedes pour sa production
CA2471219A1 (fr) 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Preparation amelioree d'une forme anhydre du chlorhydrate de 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one (chlorhydrate de ziprasidone)
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
KR20130030305A (ko) * 2004-11-16 2013-03-26 엘란 파마 인터내셔널 리미티드 주사가능한 나노입자형 올란자핀 제형
EP1863806A1 (fr) * 2005-02-11 2007-12-12 Teva Pharmaceutical Industries Ltd Ziprasidone mesylate amorphe
US20060258679A1 (en) * 2005-02-11 2006-11-16 Alex Mainfeld Process of preparing ziprasidone mesylate
EP1855651A4 (fr) * 2005-03-03 2011-06-15 Elan Pharma Int Ltd Compositions nanoparticulaires de derives d'amide heterocyclique
ITMI20050346A1 (it) 2005-03-07 2006-09-08 Dipharma Spa Forma solida di ziprasidone cloridrato
CA2500667C (fr) 2005-03-11 2013-01-15 Apotex Pharmachem Inc. Synthese de sels d'addition acide de ziprasidone et de produits intermediaires connexes au moyen de reactions solide-gaz
EP1858892A1 (fr) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd Mesylate de ziprasidone anhydre et son procede de preparation
US20060270684A1 (en) * 2005-03-14 2006-11-30 Judith Aronhime Crystalline forms of ziprasidone mesylate
ITMI20052216A1 (it) * 2005-11-18 2007-05-19 Dipharma Spa Procedimento per la preparazione di ziprasidone
MX2009011681A (es) * 2007-05-18 2009-11-10 Scidose Llc Formulaciones de ziprasidona.
CA2727573A1 (fr) * 2008-06-25 2009-12-30 Pfizer Inc. Composes diaryle et leurs utilisations
JP5893616B2 (ja) * 2010-10-18 2016-03-23 大日本住友製薬株式会社 注射用徐放性製剤
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji
EP2919788A4 (fr) 2012-11-14 2016-05-25 Univ Johns Hopkins Méthodes et compositions pour le traitement de la schizophrénie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5206366A (en) 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5312925A (en) 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5359068A (en) 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
IL126590A (en) 1996-05-07 2001-11-25 Pfizer Trihydrate salt of -5 (-2 (-4 (1 (2, 2-benzothiazole - 3yl) -1-piperazinyl) ethyl) - 6-chloro-1, 3-dihydro-2 (1H) - indole - 2On (= Ziprasidone) and pharmaceutical preparations containing it

Also Published As

Publication number Publication date
HK1017892A1 (en) 1999-12-03
CA2252898A1 (fr) 1997-11-13
EP0918772A1 (fr) 1999-06-02
CZ349398A3 (cs) 1999-09-15
EP0918772B1 (fr) 2004-10-06
IL126591A (en) 2001-11-25
AR007004A1 (es) 1999-10-13
NZ332218A (en) 2005-02-25
JPH11509867A (ja) 1999-08-31
OA10909A (en) 2001-10-26
CN1091769C (zh) 2002-10-02
KR100333215B1 (ko) 2002-06-20
AU2174797A (en) 1997-11-26
DE69731094D1 (de) 2004-11-11
EA199800912A1 (ru) 1999-04-29
IL126591A0 (en) 1999-08-17
BR9709889A (pt) 1999-08-10
CO4940466A1 (es) 2000-07-24
CN1216991A (zh) 1999-05-19
BG102892A (en) 1999-09-30
EA001190B1 (ru) 2000-12-25
NO312514B1 (no) 2002-05-21
JP3494659B2 (ja) 2004-02-09
SK150898A3 (en) 2000-02-14
TW491847B (en) 2002-06-21
NO985194L (no) 1998-11-06
AP9700976A0 (en) 1997-07-31
MY119997A (en) 2005-08-30
IS4874A (is) 1998-10-20
GT199700052A (es) 2001-08-29
CZ289215B6 (cs) 2001-12-12
US6245765B1 (en) 2001-06-12
AU731267B2 (en) 2001-03-29
ATE278689T1 (de) 2004-10-15
DE69731094T2 (de) 2006-02-23
DZ2222A1 (fr) 2002-12-03
WO1997042191A1 (fr) 1997-11-13
KR20000010824A (ko) 2000-02-25
UA46840C2 (uk) 2002-06-17
SK282837B6 (sk) 2002-12-03
ZA973876B (en) 1998-11-06
TR199802240T2 (fr) 1999-02-22
NO985194D0 (no) 1998-11-06
DK0918772T3 (da) 2005-01-10
BG63544B1 (bg) 2002-04-30
IS2080B (is) 2006-02-15
MA24171A1 (fr) 1997-12-31
HRP970236B1 (en) 2002-12-31
ES2229342T3 (es) 2005-04-16
PL329884A1 (en) 1999-04-12
CA2252898C (fr) 2003-04-08
AP765A (en) 1999-09-17
PT918772E (pt) 2004-12-31
HRP970236A2 (en) 1998-06-30
SI0918772T1 (en) 2005-02-28
EG24076A (en) 2008-05-11
PL188330B1 (pl) 2005-01-31
ID16867A (id) 1997-11-20

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